CHMP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein family. Proteins in this family are part of the ESCRT-III (endosomal sorting complex required for transport III) which degrades surface receptors, and in biosynthesis of endosomes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)8.81028166
2DNA deamination (GO:0045006)7.29103033
3proline metabolic process (GO:0006560)6.83535477
4transcription from mitochondrial promoter (GO:0006390)6.76748982
5replication fork processing (GO:0031297)6.04591007
6positive regulation of protein homooligomerization (GO:0032464)5.27299442
7embryonic process involved in female pregnancy (GO:0060136)5.27033337
8formation of translation preinitiation complex (GO:0001731)5.17297866
9viral mRNA export from host cell nucleus (GO:0046784)5.11494102
10maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.09771912
11oxidative demethylation (GO:0070989)4.90388439
12telomere maintenance via semi-conservative replication (GO:0032201)4.64346758
13pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.56967952
14regulation of protein homooligomerization (GO:0032462)4.54553512
15somatic diversification of immune receptors via somatic mutation (GO:0002566)4.54377892
16somatic hypermutation of immunoglobulin genes (GO:0016446)4.54377892
17neutrophil activation involved in immune response (GO:0002283)4.51082576
18regulation of integrin activation (GO:0033623)4.45111621
19DNA strand elongation involved in DNA replication (GO:0006271)4.26328020
20mitotic G1 DNA damage checkpoint (GO:0031571)4.26200617
21mitochondrial DNA metabolic process (GO:0032042)4.25207402
22establishment of apical/basal cell polarity (GO:0035089)4.22981143
23GDP-mannose metabolic process (GO:0019673)4.13092162
24Arp2/3 complex-mediated actin nucleation (GO:0034314)4.11930942
25deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.10356209
26DNA strand elongation (GO:0022616)3.99956722
27nucleotide-excision repair, DNA gap filling (GO:0006297)3.97545000
28regulation of translational fidelity (GO:0006450)3.96198178
29negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.93894672
30negative regulation of cell cycle arrest (GO:0071157)3.92431859
31base-excision repair (GO:0006284)3.89825927
32mitochondrial RNA metabolic process (GO:0000959)3.88225188
33viral transcription (GO:0019083)3.86468521
34negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.83612408
35establishment of protein localization to mitochondrial membrane (GO:0090151)3.78166686
36base-excision repair, AP site formation (GO:0006285)3.75133005
37pyrimidine nucleotide catabolic process (GO:0006244)3.74734062
38telomere maintenance via recombination (GO:0000722)3.74160222
39spliceosomal tri-snRNP complex assembly (GO:0000244)3.71287648
40establishment of monopolar cell polarity (GO:0061162)3.67432731
41establishment or maintenance of monopolar cell polarity (GO:0061339)3.67432731
42translational termination (GO:0006415)3.65428900
43poly(A)+ mRNA export from nucleus (GO:0016973)3.62582735
44mitotic G1/S transition checkpoint (GO:0044819)3.61633620
45DNA strand renaturation (GO:0000733)3.60250403
46cellular response to zinc ion (GO:0071294)3.57600589
47negative regulation of T cell apoptotic process (GO:0070233)3.55834754
48positive regulation of gamma-delta T cell activation (GO:0046645)3.55107457
49translational initiation (GO:0006413)3.54278493
50translational elongation (GO:0006414)3.53437539
51protein maturation by protein folding (GO:0022417)3.52463158
52NIK/NF-kappaB signaling (GO:0038061)3.52292987
53G1 DNA damage checkpoint (GO:0044783)3.51344238
54termination of RNA polymerase II transcription (GO:0006369)3.46568746
55negative regulation of RNA splicing (GO:0033119)3.45818039
56positive regulation of B cell differentiation (GO:0045579)3.45070285
57DNA ligation (GO:0006266)3.44717056
58mRNA cleavage (GO:0006379)3.39830976
59negative regulation of JAK-STAT cascade (GO:0046426)3.37336493
60DNA integration (GO:0015074)3.37150673
61positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.35544372
62negative regulation of mRNA processing (GO:0050686)3.33758243
63mitotic nuclear envelope reassembly (GO:0007084)3.32858903
64nuclear envelope reassembly (GO:0031468)3.32858903
65cullin deneddylation (GO:0010388)3.32200374
66purine deoxyribonucleotide catabolic process (GO:0009155)3.31986476
67non-recombinational repair (GO:0000726)3.30367828
68double-strand break repair via nonhomologous end joining (GO:0006303)3.30367828
69immunoglobulin mediated immune response (GO:0016064)3.28947049
70positive regulation of protein oligomerization (GO:0032461)3.23043134
71mitotic recombination (GO:0006312)3.22222600
72actin nucleation (GO:0045010)3.20849691
73DNA topological change (GO:0006265)3.20824785
74kinetochore assembly (GO:0051382)3.20030632
75telomere maintenance via telomere lengthening (GO:0010833)3.19615855
76negative regulation of erythrocyte differentiation (GO:0045647)3.18663700
77glutamine family amino acid biosynthetic process (GO:0009084)3.16404216
78protein deneddylation (GO:0000338)3.13778149
79lipoxygenase pathway (GO:0019372)3.13067142
80antigen processing and presentation of endogenous antigen (GO:0019883)3.10827456
81regulation of platelet aggregation (GO:0090330)3.08189853
82regulation of double-strand break repair via homologous recombination (GO:0010569)3.08159710
83granulocyte activation (GO:0036230)3.05445261
84resolution of meiotic recombination intermediates (GO:0000712)3.05373146
85antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.04776094
86proteasome assembly (GO:0043248)3.03315911
87pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.02572343
88nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.02493023
89purine nucleotide salvage (GO:0032261)3.02172800
90face development (GO:0060324)3.01416137
91spliceosomal snRNP assembly (GO:0000387)3.00269569
92neutrophil activation (GO:0042119)3.00130046
93negative regulation of thymocyte apoptotic process (GO:0070244)3.00075022
94dosage compensation (GO:0007549)2.99591090
95apoptotic process involved in morphogenesis (GO:0060561)2.98551856
96negative regulation of fatty acid biosynthetic process (GO:0045717)2.96548638
97negative regulation of lymphocyte apoptotic process (GO:0070229)2.96298329
98heterochromatin organization (GO:0070828)2.95548453
99SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.94885024
100positive regulation of macrophage differentiation (GO:0045651)2.90093239
101maturation of SSU-rRNA (GO:0030490)2.88776051
102maternal placenta development (GO:0001893)2.87122920
103* viral life cycle (GO:0019058)2.86960809
104regulation of mast cell degranulation (GO:0043304)2.86724059
105platelet aggregation (GO:0070527)2.86204356
106protein targeting to ER (GO:0045047)2.85373683
107cotranslational protein targeting to membrane (GO:0006613)2.84405296
108regulation of protein oligomerization (GO:0032459)2.83790267
109maturation of 5.8S rRNA (GO:0000460)2.83648666
110DNA double-strand break processing (GO:0000729)2.83617997
111trophectodermal cell differentiation (GO:0001829)2.82777394
112negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.82684791
113negative regulation of cell killing (GO:0031342)2.82684791
114autophagic vacuole fusion (GO:0000046)2.82243315
115cellular protein complex disassembly (GO:0043624)2.80753623
116polyamine biosynthetic process (GO:0006596)2.78914290
117positive regulation by host of viral transcription (GO:0043923)2.78323879
118negative regulation of protein oligomerization (GO:0032460)2.77887421
119B cell mediated immunity (GO:0019724)2.76942466
120DNA replication checkpoint (GO:0000076)2.76754905
121pinocytosis (GO:0006907)2.76614711
122meiotic chromosome segregation (GO:0045132)2.75570269
123positive regulation of developmental pigmentation (GO:0048087)2.74548725
124oxidative phosphorylation (GO:0006119)2.74089373
125mitochondrial fusion (GO:0008053)2.73932567
126positive regulation of DNA repair (GO:0045739)2.73417552
127cellular response to ATP (GO:0071318)2.72577674
128embryonic camera-type eye development (GO:0031076)2.72462338
129fibril organization (GO:0097435)2.72083587
130embryonic placenta development (GO:0001892)2.71983042
131negative regulation of nitric oxide biosynthetic process (GO:0045019)2.71688115
132deoxyribose phosphate catabolic process (GO:0046386)2.71391009
133deoxyribonucleotide catabolic process (GO:0009264)2.71196962
134barbed-end actin filament capping (GO:0051016)2.70967349
135ribosome biogenesis (GO:0042254)2.70363075
136regulation of T cell apoptotic process (GO:0070232)2.69289666
137G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.68779985
138antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.67412734
139response to interferon-beta (GO:0035456)2.66387127
140negative regulation of leukocyte apoptotic process (GO:2000107)2.65722992
141negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.65611960
142regulation of superoxide anion generation (GO:0032928)2.63926445
143pyrimidine nucleoside catabolic process (GO:0046135)2.62610603
144positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.61534354
145thrombin receptor signaling pathway (GO:0070493)2.60929776
146cytidine metabolic process (GO:0046087)2.59009256
147cytidine catabolic process (GO:0006216)2.59009256
148cytidine deamination (GO:0009972)2.59009256
149G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.58534298
150amino sugar catabolic process (GO:0046348)2.58239238
151negative regulation of myeloid cell apoptotic process (GO:0033033)2.57303236
152antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.55927389
153nucleotide salvage (GO:0043173)2.55684725
154prostanoid biosynthetic process (GO:0046457)2.55254101
155prostaglandin biosynthetic process (GO:0001516)2.55254101
156UV protection (GO:0009650)2.55128559
157regulation of platelet activation (GO:0010543)2.55002686
158regulation of mast cell activation involved in immune response (GO:0033006)2.51017770
159positive regulation of monocyte chemotaxis (GO:0090026)2.50804788
160T cell migration (GO:0072678)2.49801308
161response to peptidoglycan (GO:0032494)2.49006479
162negative regulation of interleukin-12 production (GO:0032695)2.47467313
163metallo-sulfur cluster assembly (GO:0031163)2.47348855
164iron-sulfur cluster assembly (GO:0016226)2.47348855
165regulation of gamma-delta T cell differentiation (GO:0045586)2.46654026
166regulation of gamma-delta T cell activation (GO:0046643)2.44247922
167adenosine receptor signaling pathway (GO:0001973)2.44156841
168angiogenesis involved in wound healing (GO:0060055)2.41342107
169lymphocyte chemotaxis (GO:0048247)2.41305634
170antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.41072513
171antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.41017748
172extracellular fibril organization (GO:0043206)2.40871743
173negative regulation of B cell apoptotic process (GO:0002903)2.40775578
174regulation of B cell differentiation (GO:0045577)2.40068523
175regulation of myeloid leukocyte mediated immunity (GO:0002886)2.38977178
176pentose-phosphate shunt (GO:0006098)2.38030557
177regulation of lymphocyte apoptotic process (GO:0070228)2.37280977
178regulation of natural killer cell mediated immunity (GO:0002715)2.36131985
179regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.36131985
180leukocyte degranulation (GO:0043299)2.35308357
181regulation of leukocyte degranulation (GO:0043300)2.34218442
182cyclooxygenase pathway (GO:0019371)2.32215492
183negative regulation of phagocytosis (GO:0050765)2.30551612
184NADH metabolic process (GO:0006734)2.30352917
185positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.26804765
186cellular response to interferon-beta (GO:0035458)2.26385079
187positive regulation of interleukin-8 secretion (GO:2000484)2.26246520
188regulation of homotypic cell-cell adhesion (GO:0034110)2.25818055
189positive regulation by symbiont of host defense response (GO:0052509)2.25109315
190modulation by symbiont of host defense response (GO:0052031)2.25109315
191modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.25109315
192positive regulation by organism of defense response of other organism involved in symbiotic interact2.25109315
193modulation by symbiont of host immune response (GO:0052553)2.25109315

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.06877844
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.82669491
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.63276116
4E2F7_22180533_ChIP-Seq_HELA_Human3.50942284
5RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.91395655
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.90850795
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.74048536
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.67583691
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.49256580
10* VDR_21846776_ChIP-Seq_THP-1_Human2.41712861
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.36610731
12SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.33116722
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.32591118
14LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.21212927
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.19077147
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.17305093
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.15411970
18ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.10338435
19MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.04253876
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.02032102
21DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.96270423
22KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.93481342
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.92115357
24E2F1_18555785_ChIP-Seq_MESCs_Mouse1.90056028
25XRN2_22483619_ChIP-Seq_HELA_Human1.87806699
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.87746669
27DCP1A_22483619_ChIP-Seq_HELA_Human1.86283287
28YY1_21170310_ChIP-Seq_MESCs_Mouse1.84825537
29STAT3_1855785_ChIP-Seq_MESCs_Mouse1.84614693
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.83834907
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.81452789
32LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.78646493
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.77849454
34UTX_26944678_Chip-Seq_JUKART_Human1.77554803
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.74903018
36MYC_22102868_ChIP-Seq_BL_Human1.74853453
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73566740
38* LXR_22292898_ChIP-Seq_THP-1_Human1.71704332
39GABP_19822575_ChIP-Seq_HepG2_Human1.71591778
40ELF1_20517297_ChIP-Seq_JURKAT_Human1.70796221
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.69905144
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.69754548
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.69680870
44KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.69061633
45EST1_17652178_ChIP-ChIP_JURKAT_Human1.68417070
46HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.66573332
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.66252674
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.65399398
49SPI1_23547873_ChIP-Seq_NB4_Human1.64572518
50VDR_24763502_ChIP-Seq_THP-1_Human1.64110748
51RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63616243
52* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.61480872
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.60937521
54MAF_26560356_Chip-Seq_TH1_Human1.60609135
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60592856
56TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59873380
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.59752675
58CREB1_15753290_ChIP-ChIP_HEK293T_Human1.56359823
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.54029677
60* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.54007239
61NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.53379051
62E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.52020608
63* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51694219
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.51096611
65MAF_26560356_Chip-Seq_TH2_Human1.51070143
66TTF2_22483619_ChIP-Seq_HELA_Human1.50655066
67SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50212214
68SCL_19346495_ChIP-Seq_HPC-7_Human1.49301702
69* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48082716
70VDR_23849224_ChIP-Seq_CD4+_Human1.47968806
71SRY_22984422_ChIP-ChIP_TESTIS_Rat1.47422838
72MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45917215
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.45548438
74KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.45548438
75KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.45548438
76PU.1_20513432_ChIP-Seq_Bcells_Mouse1.44428061
77NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.44384063
78KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44082390
79TET1_21451524_ChIP-Seq_MESCs_Mouse1.43648235
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.42104981
81ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41002573
82P68_20966046_ChIP-Seq_HELA_Human1.40177152
83GATA1_19941827_ChIP-Seq_MEL_Mouse1.39752757
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39126211
85SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38861254
86BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38150954
87SPI1_23127762_ChIP-Seq_K562_Human1.34258940
88CTCF_26484167_Chip-Seq_Bcells_Mouse1.33523408
89MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.33360034
90NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33255984
91SA1_27219007_Chip-Seq_ERYTHROID_Human1.31996914
92KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31264207
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.30722859
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.30295227
95NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30133008
96CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30127306
97SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29581380
98IRF8_27001747_Chip-Seq_BMDM_Mouse1.28101291
99SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26635279
100* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25619016
101TCF3_18692474_ChIP-Seq_MEFs_Mouse1.25238413
102MYB_26560356_Chip-Seq_TH2_Human1.25059484
103MYB_21317192_ChIP-Seq_ERMYB_Mouse1.24552294
104OCT4_18692474_ChIP-Seq_MEFs_Mouse1.24349845
105CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24260038
106TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23554563
107SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.23314716
108SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.22656612
109CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.22466265
110RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22110278
111PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21638417
112MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20809795
113GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20796298
114CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20633009
115STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.20540437
116POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20016110
117NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.19157558
118CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18484011
119HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.18040334
120* KDM2B_26808549_Chip-Seq_DND41_Human1.18034293
121SRF_21415370_ChIP-Seq_HL-1_Mouse1.17667060
122E2F1_21310950_ChIP-Seq_MCF-7_Human1.17089467
123* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16706371
124POU5F1_16518401_ChIP-PET_MESCs_Mouse1.16577898
125CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15907791
126KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.15899670
127TFEB_21752829_ChIP-Seq_HELA_Human1.15763277
128NANOG_21062744_ChIP-ChIP_HESCs_Human1.15710814
129YY1_22570637_ChIP-Seq_MALME-3M_Human1.14563654
130SPI1_20517297_ChIP-Seq_HL60_Human1.14245206
131* RACK7_27058665_Chip-Seq_MCF-7_Human1.14228600
132ZNF263_19887448_ChIP-Seq_K562_Human1.13489784
133ELK3_25401928_ChIP-Seq_HUVEC_Human1.13191194
134SOX2_18692474_ChIP-Seq_MEFs_Mouse1.11199483
135* CTCF_21964334_Chip-Seq_Bcells_Human1.11054082
136PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10198502
137POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.10078276
138SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09444462
139CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08688889
140CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08520770
141CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07917878
142TCF7_22412390_ChIP-Seq_EML_Mouse1.07136591
143FOXP3_21729870_ChIP-Seq_TREG_Human1.06867908
144KDM5A_27292631_Chip-Seq_BREAST_Human1.06511322
145PHF8_20622854_ChIP-Seq_HELA_Human1.05914305
146ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05824673
147TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05457136
148BCL6_27268052_Chip-Seq_Bcells_Human1.05447475
149STAT1_20625510_ChIP-Seq_HELA_Human1.05102047
150SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04863498
151CTCF_21964334_ChIP-Seq_BJAB-B_Human1.04767109
152FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04574428
153* FOXP1_21924763_ChIP-Seq_HESCs_Human1.04397804
154TCF3_18692474_ChIP-Seq_MESCs_Mouse1.03977131
155CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03896417
156* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03472520
157SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03450516
158EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02803690
159* NCOR1_26117541_ChIP-Seq_K562_Human1.02780553
160CIITA_25753668_ChIP-Seq_RAJI_Human1.02726186
161BCOR_27268052_Chip-Seq_Bcells_Human1.01613359
162ERG_21242973_ChIP-ChIP_JURKAT_Human1.01387306
163TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00729368
164SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97791225
165SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96390564

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.03827749
2MP0009278_abnormal_bone_marrow4.36284447
3MP0010030_abnormal_orbit_morphology3.39519144
4MP0003436_decreased_susceptibility_to3.02247465
5MP0005171_absent_coat_pigmentation2.95922012
6MP0010094_abnormal_chromosome_stability2.94822150
7MP0003303_peritoneal_inflammation2.94115628
8MP0004957_abnormal_blastocyst_morpholog2.93883171
9MP0005671_abnormal_response_to2.89305121
10MP0003693_abnormal_embryo_hatching2.84577349
11MP0004233_abnormal_muscle_weight2.84027783
12MP0001835_abnormal_antigen_presentation2.63570828
13MP0002148_abnormal_hypersensitivity_rea2.63530970
14MP0001545_abnormal_hematopoietic_system2.61233158
15MP0005397_hematopoietic_system_phenotyp2.61233158
16MP0003724_increased_susceptibility_to2.57387655
17MP0000465_gastrointestinal_hemorrhage2.50613530
18MP0004510_myositis2.46699896
19MP0003111_abnormal_nucleus_morphology2.45432206
20MP0009785_altered_susceptibility_to2.45023512
21MP0005025_abnormal_response_to2.40461019
22MP0005000_abnormal_immune_tolerance2.38200923
23MP0010352_gastrointestinal_tract_polyps2.18825427
24MP0002419_abnormal_innate_immunity2.17037154
25MP0003077_abnormal_cell_cycle2.11630523
26MP0008058_abnormal_DNA_repair2.07973515
27MP0005083_abnormal_biliary_tract1.97969499
28MP0002723_abnormal_immune_serum1.97299286
29MP0000490_abnormal_crypts_of1.95374419
30MP0002653_abnormal_ependyma_morphology1.94958634
31MP0002009_preneoplasia1.94636912
32MP0008932_abnormal_embryonic_tissue1.93840028
33MP0008004_abnormal_stomach_pH1.88864979
34MP0002420_abnormal_adaptive_immunity1.88195606
35MP0003191_abnormal_cellular_cholesterol1.88153443
36MP0005174_abnormal_tail_pigmentation1.88101873
37MP0001819_abnormal_immune_cell1.86481419
38MP0002452_abnormal_antigen_presenting1.86359864
39MP0001800_abnormal_humoral_immune1.85453036
40MP0008260_abnormal_autophagy1.80476145
41MP0003786_premature_aging1.79709222
42MP0003119_abnormal_digestive_system1.77008499
43MP0005451_abnormal_body_composition1.74982257
44MP0001533_abnormal_skeleton_physiology1.73847029
45MP0001790_abnormal_immune_system1.73428110
46MP0005387_immune_system_phenotype1.73428110
47MP0003567_abnormal_fetal_cardiomyocyte1.69309002
48MP0008995_early_reproductive_senescence1.66672792
49MP0001697_abnormal_embryo_size1.62440900
50MP0001845_abnormal_inflammatory_respons1.60443444
51MP0005076_abnormal_cell_differentiation1.58373883
52MP0004947_skin_inflammation1.56321205
53MP0010155_abnormal_intestine_physiology1.55791541
54MP0003075_altered_response_to1.53854154
55MP0002132_abnormal_respiratory_system1.53584190
56MP0004133_heterotaxia1.52700609
57MP0009764_decreased_sensitivity_to1.52162944
58MP0005058_abnormal_lysosome_morphology1.51378704
59MP0000716_abnormal_immune_system1.51067840
60MP0002282_abnormal_trachea_morphology1.50493437
61MP0002086_abnormal_extraembryonic_tissu1.47834227
62MP0003890_abnormal_embryonic-extraembry1.46992057
63MP0000371_diluted_coat_color1.44470388
64MP0000685_abnormal_immune_system1.43360334
65MP0002269_muscular_atrophy1.40390480
66MP0002429_abnormal_blood_cell1.39247346
67MP0003283_abnormal_digestive_organ1.39089188
68MP0001730_embryonic_growth_arrest1.38889710
69MP0008469_abnormal_protein_level1.36072111
70MP0002019_abnormal_tumor_incidence1.33736688
71MP0000350_abnormal_cell_proliferation1.31738146
72MP0005075_abnormal_melanosome_morpholog1.30211825
73MP0005380_embryogenesis_phenotype1.27923694
74MP0001672_abnormal_embryogenesis/_devel1.27923694
75MP0001293_anophthalmia1.27056486
76MP0002084_abnormal_developmental_patter1.27012093
77MP0009840_abnormal_foam_cell1.25697370
78MP0002085_abnormal_embryonic_tissue1.24915068
79MP0001873_stomach_inflammation1.22809232
80MP0002080_prenatal_lethality1.21785817
81MP0009333_abnormal_splenocyte_physiolog1.21604974
82MP0001853_heart_inflammation1.17919838
83MP0000015_abnormal_ear_pigmentation1.17408899
84MP0003866_abnormal_defecation1.16373532
85MP0001663_abnormal_digestive_system1.15035589
86MP0000313_abnormal_cell_death1.13857953
87MP0006054_spinal_hemorrhage1.12059151
88MP0008007_abnormal_cellular_replicative1.11280787
89MP0003828_pulmonary_edema1.11122703
90MP0002249_abnormal_larynx_morphology1.10986749
91MP0009763_increased_sensitivity_to1.10602375
92MP0003172_abnormal_lysosome_physiology1.10522323
93MP0003186_abnormal_redox_activity1.10219791
94MP0002998_abnormal_bone_remodeling1.09972559
95MP0003806_abnormal_nucleotide_metabolis1.09212939
96MP0002405_respiratory_system_inflammati1.08961755
97MP0002139_abnormal_hepatobiliary_system1.07706330
98MP0001849_ear_inflammation1.07477098
99MP0003984_embryonic_growth_retardation1.07324459
100MP0005266_abnormal_metabolism1.06323003
101MP0000372_irregular_coat_pigmentation1.05511501
102MP0002396_abnormal_hematopoietic_system1.05225087
103MP0002332_abnormal_exercise_endurance1.04786961
104MP0004197_abnormal_fetal_growth/weight/1.04200697
105MP0003300_gastrointestinal_ulcer1.03901540
106MP0008877_abnormal_DNA_methylation1.03716836
107MP0002088_abnormal_embryonic_growth/wei1.02747529
108MP0000470_abnormal_stomach_morphology1.02112494
109MP0005166_decreased_susceptibility_to1.01093069
110MP0003279_aneurysm0.99939459
111MP0006072_abnormal_retinal_apoptosis0.99006535
112MP0003763_abnormal_thymus_physiology0.98364891
113MP0006035_abnormal_mitochondrial_morpho0.97218257
114MP0004019_abnormal_vitamin_homeostasis0.96589723
115MP0003453_abnormal_keratinocyte_physiol0.95271657
116MP0000689_abnormal_spleen_morphology0.91977131
117MP0001851_eye_inflammation0.90380627
118MP0001542_abnormal_bone_strength0.88311653
119MP0009053_abnormal_anal_canal0.87719630
120MP0005085_abnormal_gallbladder_physiolo0.86792377
121MP0003705_abnormal_hypodermis_morpholog0.86429149
122MP0009765_abnormal_xenobiotic_induced0.86143602
123MP0000477_abnormal_intestine_morphology0.86026204
124MP0003137_abnormal_impulse_conducting0.85883062
125MP0003718_maternal_effect0.84878898
126MP0002111_abnormal_tail_morphology0.84558992
127MP0005390_skeleton_phenotype0.84507090
128MP0005023_abnormal_wound_healing0.83941021
129MP0001727_abnormal_embryo_implantation0.83901128
130MP0003448_altered_tumor_morphology0.82988487
131MP0008874_decreased_physiological_sensi0.81460919
132MP0005584_abnormal_enzyme/coenzyme_acti0.81424368
133MP0005167_abnormal_blood-brain_barrier0.81414095
134MP0005165_increased_susceptibility_to0.80508611
135MP0006036_abnormal_mitochondrial_physio0.80426140
136MP0000749_muscle_degeneration0.80002053
137MP0005084_abnormal_gallbladder_morpholo0.79907940
138MP0003795_abnormal_bone_structure0.79734333
139MP0002933_joint_inflammation0.79583771
140MP0000604_amyloidosis0.78109853
141MP0002138_abnormal_hepatobiliary_system0.77294656
142MP0005330_cardiomyopathy0.76645763
143MP0003656_abnormal_erythrocyte_physiolo0.76566521
144MP0000462_abnormal_digestive_system0.76375116
145MP0000858_altered_metastatic_potential0.75955570
146MP0006082_CNS_inflammation0.75916084
147MP0002075_abnormal_coat/hair_pigmentati0.75718226
148MP0005365_abnormal_bile_salt0.75703954
149MP0005319_abnormal_enzyme/_coenzyme0.74690291
150MP0004264_abnormal_extraembryonic_tissu0.74472756
151MP0000249_abnormal_blood_vessel0.73676227
152MP0002722_abnormal_immune_system0.73675332
153MP0005381_digestive/alimentary_phenotyp0.73636945
154MP0003646_muscle_fatigue0.73388551
155MP0001764_abnormal_homeostasis0.72205130
156MP0003221_abnormal_cardiomyocyte_apopto0.71944927
157MP0005501_abnormal_skin_physiology0.70236955
158MP0002932_abnormal_joint_morphology0.70060356
159MP0005310_abnormal_salivary_gland0.69780410
160MP0001324_abnormal_eye_pigmentation0.69269052
161MP0005670_abnormal_white_adipose0.68762544
162MP0001145_abnormal_male_reproductive0.67902606
163MP0000343_altered_response_to0.67831928
164MP0002796_impaired_skin_barrier0.67249346
165MP0000703_abnormal_thymus_morphology0.66876451
166MP0002166_altered_tumor_susceptibility0.66709812
167MP0002398_abnormal_bone_marrow0.66109272
168MP0001186_pigmentation_phenotype0.64230383
169MP0000358_abnormal_cell_content/0.63436022
170MP0000639_abnormal_adrenal_gland0.61037480
171MP0005464_abnormal_platelet_physiology0.60985753

Predicted human phenotypes

RankGene SetZ-score
1Petechiae (HP:0000967)5.96428710
2Purpura (HP:0000979)5.03938523
3Pustule (HP:0200039)4.87040945
4Prolonged bleeding time (HP:0003010)4.59268446
5Increased IgM level (HP:0003496)4.44787049
6Poikiloderma (HP:0001029)4.39302654
7Concave nail (HP:0001598)4.35825606
8Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.21644743
9Rib fusion (HP:0000902)4.19569345
10Annular pancreas (HP:0001734)4.10774348
11Tongue fasciculations (HP:0001308)3.92777308
12Abnormal hemoglobin (HP:0011902)3.81597204
13Abnormality of glycolipid metabolism (HP:0010969)3.79894095
14Abnormality of liposaccharide metabolism (HP:0010968)3.79894095
15Abnormality of glycosphingolipid metabolism (HP:0004343)3.79894095
16Abnormality of macrophages (HP:0004311)3.79229769
17Rectovaginal fistula (HP:0000143)3.75271688
18Rectal fistula (HP:0100590)3.75271688
19Muscle fibrillation (HP:0010546)3.69886828
20Epistaxis (HP:0000421)3.66539580
21Alopecia of scalp (HP:0002293)3.63997166
22Menorrhagia (HP:0000132)3.63486286
23Facial hemangioma (HP:0000329)3.58249685
24Selective tooth agenesis (HP:0001592)3.53885072
25Abnormal platelet volume (HP:0011876)3.46882118
26Elevated erythrocyte sedimentation rate (HP:0003565)3.45973878
27Chronic obstructive pulmonary disease (HP:0006510)3.44948277
28Obstructive lung disease (HP:0006536)3.44948277
29Vaginal fistula (HP:0004320)3.42897752
30Cholecystitis (HP:0001082)3.41327345
31Abnormal gallbladder physiology (HP:0012438)3.41327345
32Hepatosplenomegaly (HP:0001433)3.38532789
33Increased mean platelet volume (HP:0011877)3.34108058
34Diaphragmatic weakness (HP:0009113)3.21436925
35Ulnar bowing (HP:0003031)3.19623051
36Orthostatic hypotension (HP:0001278)3.16539454
37Hypochromic anemia (HP:0001931)3.15047593
38Male infertility (HP:0003251)3.12812739
39Absent thumb (HP:0009777)3.12506135
40Intestinal fistula (HP:0100819)3.11553676
41Mesangial abnormality (HP:0001966)3.11502359
42Turricephaly (HP:0000262)3.11252750
43Aplasia/hypoplasia of the humerus (HP:0006507)3.10251607
44Patellar aplasia (HP:0006443)3.08242506
45Increased serum ferritin (HP:0003281)3.07331463
46Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.06827068
47Vertebral hypoplasia (HP:0008417)3.06827068
48Increased cerebral lipofuscin (HP:0011813)3.04205456
49Vacuolated lymphocytes (HP:0001922)3.00000555
50Stomatitis (HP:0010280)2.96619738
51Albinism (HP:0001022)2.88313923
52Aplasia/Hypoplasia of the patella (HP:0006498)2.87554676
53Abnormality of male internal genitalia (HP:0000022)2.84458272
54Increased neuronal autofluorescent lipopigment (HP:0002074)2.81847711
55Growth hormone excess (HP:0000845)2.81003524
56Systemic lupus erythematosus (HP:0002725)2.80848788
57Short humerus (HP:0005792)2.79498420
58Reticulocytopenia (HP:0001896)2.77963300
59Joint stiffness (HP:0001387)2.77079975
60Eczematoid dermatitis (HP:0000976)2.74151234
61Gingival bleeding (HP:0000225)2.73352044
62Mucopolysacchariduria (HP:0008155)2.72324466
63Urinary glycosaminoglycan excretion (HP:0003541)2.72324466
64Absent radius (HP:0003974)2.68793951
65Recurrent abscess formation (HP:0002722)2.68180233
66Polycythemia (HP:0001901)2.68124290
67Premature graying of hair (HP:0002216)2.67651583
68Muscle fiber atrophy (HP:0100295)2.64561988
69Ragged-red muscle fibers (HP:0003200)2.63247565
70Myositis (HP:0100614)2.62615699
71Basal cell carcinoma (HP:0002671)2.62136998
72Exertional dyspnea (HP:0002875)2.61998336
73Dysautonomia (HP:0002459)2.61898347
74Spinal muscular atrophy (HP:0007269)2.61466865
75Abnormality of the aortic arch (HP:0012303)2.61151026
76Rhabdomyolysis (HP:0003201)2.61125673
77Intestinal atresia (HP:0011100)2.61072267
78Squamous cell carcinoma (HP:0002860)2.60827668
79Congenital hip dislocation (HP:0001374)2.54764592
80Hypokinesia (HP:0002375)2.52334522
81Abnormal platelet function (HP:0011869)2.51477139
82Impaired platelet aggregation (HP:0003540)2.51477139
83Mediastinal lymphadenopathy (HP:0100721)2.50087714
84Abnormality of cells of the erythroid lineage (HP:0012130)2.49764165
85Absent forearm bone (HP:0003953)2.48600038
86Aplasia involving forearm bones (HP:0009822)2.48600038
87Abnormality of iron homeostasis (HP:0011031)2.48052082
88Loss of speech (HP:0002371)2.45510843
89Increased muscle lipid content (HP:0009058)2.44524440
90Hypochromic microcytic anemia (HP:0004840)2.44467657
91Recurrent bacterial skin infections (HP:0005406)2.43886371
92Abnormal number of erythroid precursors (HP:0012131)2.41274770
93IgA deficiency (HP:0002720)2.40573184
94Dysostosis multiplex (HP:0000943)2.38694824
95Cerebral palsy (HP:0100021)2.38269135
96Degeneration of anterior horn cells (HP:0002398)2.37079597
97Abnormality of the anterior horn cell (HP:0006802)2.37079597
98Vertebral compression fractures (HP:0002953)2.35124884
99Abnormality of lateral ventricle (HP:0030047)2.33086709
100Increased intramyocellular lipid droplets (HP:0012240)2.28414758
101Abnormality of mucopolysaccharide metabolism (HP:0011020)2.28035364
102Abnormality of polysaccharide metabolism (HP:0011012)2.28035364
103Abnormality of glycosaminoglycan metabolism (HP:0004371)2.28035364
104Prolonged neonatal jaundice (HP:0006579)2.27652462
105Spontaneous hematomas (HP:0007420)2.27508849
106Bifid uvula (HP:0000193)2.26183558
107Granulocytopenia (HP:0001913)2.25541203
108Redundant skin (HP:0001582)2.25505947
109Hypotrichosis (HP:0001006)2.25157696
110Hypertensive crisis (HP:0100735)2.23788094
111Short chin (HP:0000331)2.23157760
112Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.22265276
113Centrally nucleated skeletal muscle fibers (HP:0003687)2.21570768
114Reduced antithrombin III activity (HP:0001976)2.19338655
115Abnormal number of incisors (HP:0011064)2.18960932
116Recurrent fungal infections (HP:0002841)2.18312775
117Choanal stenosis (HP:0000452)2.15703967
118Recurrent viral infections (HP:0004429)2.14476531
119Abnormal pupillary function (HP:0007686)2.13106192
120Meningitis (HP:0001287)2.12226877
121Broad alveolar ridges (HP:0000187)2.11927342
122Hypoplasia of the radius (HP:0002984)2.10791989
123Aplastic anemia (HP:0001915)2.10476808
124Asymmetric septal hypertrophy (HP:0001670)2.10063197
125Encephalitis (HP:0002383)2.09895692
126Progressive neurologic deterioration (HP:0002344)2.08523294
127Orchitis (HP:0100796)2.07849118
128Coronal craniosynostosis (HP:0004440)2.07686509
129Type I transferrin isoform profile (HP:0003642)2.07330261
130Cerebral aneurysm (HP:0004944)2.02710042
131Premature skin wrinkling (HP:0100678)2.01117804
132Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.01109909
133Abnormal protein N-linked glycosylation (HP:0012347)2.01109909
134Abnormal protein glycosylation (HP:0012346)2.01109909
135Abnormal glycosylation (HP:0012345)2.01109909
136Hypergammaglobulinemia (HP:0010702)2.00443663
137Generalized amyotrophy (HP:0003700)1.99686961
138Autoimmune thrombocytopenia (HP:0001973)1.99088189
139Exercise-induced myalgia (HP:0003738)1.98780491
140Abnormality of transition element cation homeostasis (HP:0011030)1.98764802
141Distal lower limb muscle weakness (HP:0009053)1.96881286
142Aplasia of the musculature (HP:0100854)1.96238844
143Leukocytosis (HP:0001974)1.96148909
144Hamartoma (HP:0010566)1.95581352
145Autoimmune hemolytic anemia (HP:0001890)1.92538481
146Bowed forearm bones (HP:0003956)1.92147601
147Bowing of the arm (HP:0006488)1.92147601
148Hypobetalipoproteinemia (HP:0003563)1.91943828
149Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.91831495
150Large for gestational age (HP:0001520)1.90966435
151Breast hypoplasia (HP:0003187)1.90938159
152Decreased activity of mitochondrial respiratory chain (HP:0008972)1.90494689
153Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.90494689
154Hypercortisolism (HP:0001578)1.89677948
155T lymphocytopenia (HP:0005403)1.88368663
156Malnutrition (HP:0004395)1.87790064
157Increased IgE level (HP:0003212)1.87221565
158Abnormality of the ileum (HP:0001549)1.87182836
159Hepatocellular necrosis (HP:0001404)1.86762408
160Trismus (HP:0000211)1.86423657
161Absent rod-and cone-mediated responses on ERG (HP:0007688)1.86142164
162Abnormality of the heme biosynthetic pathway (HP:0010472)1.85683520
163Generalized aminoaciduria (HP:0002909)1.85101832
164Agammaglobulinemia (HP:0004432)1.84791980
165Bilateral sensorineural hearing impairment (HP:0008619)1.84467697
166Anteriorly placed anus (HP:0001545)1.84212723
167Rough bone trabeculation (HP:0100670)1.83898291
168Pancreatic islet-cell hyperplasia (HP:0004510)1.82737702
169Eosinophilia (HP:0001880)1.82306203
170Carpal bone hypoplasia (HP:0001498)1.81962382
171Episodic fever (HP:0001954)1.81798946
172Severe combined immunodeficiency (HP:0004430)1.81022985
173Type 2 muscle fiber atrophy (HP:0003554)1.80616055
174Gastrointestinal inflammation (HP:0004386)1.80521556
175Abnormality of the alveolar ridges (HP:0006477)1.80354946
176Bulbar palsy (HP:0001283)1.80151617
177Joint swelling (HP:0001386)1.79182237
178Lower limb hyperreflexia (HP:0002395)1.79015673
179Metaphyseal cupping (HP:0003021)1.78063683
180Myoglobinuria (HP:0002913)1.78062705
181Gastrointestinal dysmotility (HP:0002579)1.77694572
182Hypertriglyceridemia (HP:0002155)1.77684412
183Retrobulbar optic neuritis (HP:0100654)1.77387980
184Optic neuritis (HP:0100653)1.77387980
185Abnormality of T cells (HP:0002843)1.77343549
186Urticaria (HP:0001025)1.76647368
187Capillary hemangiomas (HP:0005306)1.76636514
188Inflammation of the large intestine (HP:0002037)1.75801420
189Vasculitis (HP:0002633)1.75588526
190Acute hepatic failure (HP:0006554)1.74768361

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.00987420
2TLK14.62238349
3DDR23.90115568
4MAPK153.77588188
5MAP3K113.70029761
6MAP3K63.06889147
7MATK2.57732128
8PIM22.44239906
9DAPK12.36609959
10MAP3K102.35444878
11BUB12.30638391
12PINK12.30219161
13TXK2.11235192
14ARAF2.02940384
15VRK21.88658849
16TYRO31.88310041
17CDK71.87468535
18KIT1.83940899
19UHMK11.83031969
20IRAK31.82853870
21FGR1.82394619
22RIPK41.77766633
23BMX1.77720200
24NME21.77616800
25DYRK1B1.76397339
26GRK61.70939883
27FES1.70048147
28CSK1.67415099
29TAOK31.59926510
30PDGFRA1.56200407
31YES11.50432640
32WEE11.49435113
33PRKD21.48242728
34LIMK11.46141230
35TAOK21.42679325
36KDR1.37827958
37IKBKB1.35907570
38ABL21.32395151
39IKBKE1.32218229
40RPS6KL11.30309494
41RPS6KC11.30309494
42BTK1.26679850
43BCKDK1.24418851
44NEK21.24118384
45DYRK31.22705958
46PAK41.19779888
47MAP3K31.19060035
48PLK11.18109908
49PIM11.17402352
50IRAK41.16655671
51TNK21.15825407
52SYK1.15437417
53RPS6KA61.13647725
54TTN1.12069649
55MAPK111.10686667
56CDK61.09811167
57TRIB31.09502654
58CSF1R1.03879377
59MAP2K71.03782889
60NEK11.02040751
61TESK21.00626622
62GRK70.97642857
63CHEK20.95959351
64JAK30.94274330
65CDC70.94057304
66SIK30.93256632
67RPS6KB20.93197975
68MYLK0.90986498
69TAOK10.88081110
70PHKG10.87628837
71PHKG20.87628837
72CSNK1G30.85154208
73ILK0.83226223
74LATS20.81153653
75TEC0.81145601
76PRPF4B0.81021531
77LCK0.80865764
78AURKA0.79349713
79RPS6KA10.75539770
80GSK3A0.75262542
81TGFBR20.74089636
82GRK50.73023307
83MAP3K80.72735485
84MAP3K50.72410671
85TRPM70.70528596
86HCK0.68371565
87AURKB0.67949268
88ATR0.66874871
89PIK3CG0.66080600
90EIF2AK10.65231194
91SCYL20.64672667
92TESK10.64658435
93CDC42BPA0.64636897
94MARK30.64092816
95MUSK0.63202518
96STK100.62644348
97BLK0.61683926
98MAP4K10.61524233
99LRRK20.61197267
100MAP3K140.60913803
101EPHB10.60864506
102TRIM280.60095926
103CSNK2A10.59561841
104MAP3K10.58107330
105EPHA20.57724807
106STK160.56387737
107DAPK30.55465105
108OBSCN0.53105896
109MAPKAPK30.52519008
110TYK20.51785974
111PRKCQ0.51627499
112CSNK1A1L0.50634664
113PAK10.50556391
114MAP4K20.50443087
115LMTK20.48976844
116MOS0.48446974
117SIK10.47703177
118ITK0.47281321
119PRKG20.47073096
120IRAK20.46403511
121PTK2B0.44945244
122CSNK1G20.44580592
123LYN0.44158642
124MAPK120.44096961
125HIPK20.42446144
126CAMK2G0.42311183
127TTK0.41562182
128RPS6KA40.41371762
129SMG10.40993627
130CDK20.40525940
131VRK10.40212375
132MAP2K60.39882183
133PRKAA10.39785832
134AKT30.39417937
135CDK40.39009863
136PRKD10.38716501
137MAPKAPK20.38490364
138BRAF0.38305722
139CSNK2A20.37071410
140MTOR0.35828308
141ERN10.35785218
142MAP2K20.33685182
143PBK0.33550079
144CDK190.32538077
145FYN0.31796352
146TBK10.31307329
147MAPK40.30363680
148MAP2K30.29949480
149BRSK20.28405351
150FLT30.26740435
151ZAP700.26739797
152SRPK10.25739195
153PRKCI0.25732813
154PAK20.25509682
155BRSK10.24940287
156RPS6KB10.24873777
157CDK80.24099866
158EIF2AK30.23900671
159EGFR0.23147463
160MAPK30.21942651
161PRKCD0.21122726
162DYRK20.20249213

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.83863694
2Mismatch repair_Homo sapiens_hsa034304.65978122
3Base excision repair_Homo sapiens_hsa034104.62353475
4Ribosome_Homo sapiens_hsa030103.59390932
5Spliceosome_Homo sapiens_hsa030402.83538889
6Fatty acid biosynthesis_Homo sapiens_hsa000612.82815755
7Other glycan degradation_Homo sapiens_hsa005112.80535812
8Proteasome_Homo sapiens_hsa030502.63832176
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.40778177
10Nucleotide excision repair_Homo sapiens_hsa034202.35413122
11RNA transport_Homo sapiens_hsa030132.24238373
12Lysosome_Homo sapiens_hsa041422.14867174
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.09289163
14Hematopoietic cell lineage_Homo sapiens_hsa046401.98478709
15Homologous recombination_Homo sapiens_hsa034401.92559535
16Fatty acid elongation_Homo sapiens_hsa000621.91372868
17Biosynthesis of amino acids_Homo sapiens_hsa012301.83596689
18Allograft rejection_Homo sapiens_hsa053301.83536500
19Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.82611684
20Sulfur relay system_Homo sapiens_hsa041221.76281880
21Folate biosynthesis_Homo sapiens_hsa007901.74852404
22Graft-versus-host disease_Homo sapiens_hsa053321.72165074
23Autoimmune thyroid disease_Homo sapiens_hsa053201.70934896
24Rheumatoid arthritis_Homo sapiens_hsa053231.65573387
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.64487607
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.63392137
27Arginine and proline metabolism_Homo sapiens_hsa003301.63266053
28Cell cycle_Homo sapiens_hsa041101.62873002
29Salmonella infection_Homo sapiens_hsa051321.62686361
30Antigen processing and presentation_Homo sapiens_hsa046121.62684740
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.62034466
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.56827651
33Osteoclast differentiation_Homo sapiens_hsa043801.55333013
34Pyrimidine metabolism_Homo sapiens_hsa002401.55021692
35Fructose and mannose metabolism_Homo sapiens_hsa000511.54494977
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.52311482
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.48373864
38mRNA surveillance pathway_Homo sapiens_hsa030151.48005731
39Platelet activation_Homo sapiens_hsa046111.46614118
40Staphylococcus aureus infection_Homo sapiens_hsa051501.45741727
41Fanconi anemia pathway_Homo sapiens_hsa034601.44847852
42RNA polymerase_Homo sapiens_hsa030201.44314916
43p53 signaling pathway_Homo sapiens_hsa041151.42194890
44Sulfur metabolism_Homo sapiens_hsa009201.42185257
45Leishmaniasis_Homo sapiens_hsa051401.38146214
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.35390991
47Malaria_Homo sapiens_hsa051441.33562547
48Notch signaling pathway_Homo sapiens_hsa043301.30814834
49One carbon pool by folate_Homo sapiens_hsa006701.18800093
50Asthma_Homo sapiens_hsa053101.16459286
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15776434
52Phagosome_Homo sapiens_hsa041451.15571649
53mTOR signaling pathway_Homo sapiens_hsa041501.14411980
54Pertussis_Homo sapiens_hsa051331.14313035
55Tuberculosis_Homo sapiens_hsa051521.12615823
56Shigellosis_Homo sapiens_hsa051311.11933178
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.11432338
58Pentose and glucuronate interconversions_Homo sapiens_hsa000401.09179455
59Hedgehog signaling pathway_Homo sapiens_hsa043401.07609645
60Intestinal immune network for IgA production_Homo sapiens_hsa046721.07364153
61Collecting duct acid secretion_Homo sapiens_hsa049661.03523061
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03149718
63Hippo signaling pathway_Homo sapiens_hsa043901.02237314
64Bladder cancer_Homo sapiens_hsa052191.01130178
65Type I diabetes mellitus_Homo sapiens_hsa049400.97671217
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.93590936
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92204857
68Glutathione metabolism_Homo sapiens_hsa004800.91981493
69Galactose metabolism_Homo sapiens_hsa000520.91713989
70T cell receptor signaling pathway_Homo sapiens_hsa046600.91548530
71Arachidonic acid metabolism_Homo sapiens_hsa005900.89941120
72Parkinsons disease_Homo sapiens_hsa050120.87442037
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86161208
74* Endocytosis_Homo sapiens_hsa041440.85671408
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85518336
76Primary immunodeficiency_Homo sapiens_hsa053400.83779786
77Fatty acid metabolism_Homo sapiens_hsa012120.83555010
78Huntingtons disease_Homo sapiens_hsa050160.82477829
79Chemokine signaling pathway_Homo sapiens_hsa040620.80858111
80Peroxisome_Homo sapiens_hsa041460.80523848
81B cell receptor signaling pathway_Homo sapiens_hsa046620.80490228
82RNA degradation_Homo sapiens_hsa030180.80144352
83Measles_Homo sapiens_hsa051620.78396825
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.78357405
85Legionellosis_Homo sapiens_hsa051340.77935926
86Carbon metabolism_Homo sapiens_hsa012000.77471519
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77426114
88Vibrio cholerae infection_Homo sapiens_hsa051100.77189917
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76336408
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76275466
91TNF signaling pathway_Homo sapiens_hsa046680.74502859
92Adherens junction_Homo sapiens_hsa045200.73197391
93Selenocompound metabolism_Homo sapiens_hsa004500.72355747
94Thyroid cancer_Homo sapiens_hsa052160.72246190
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67950302
96Viral myocarditis_Homo sapiens_hsa054160.67533949
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67296911
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66673530
99Oxidative phosphorylation_Homo sapiens_hsa001900.66657730
100Epstein-Barr virus infection_Homo sapiens_hsa051690.66556258
101Pentose phosphate pathway_Homo sapiens_hsa000300.66462254
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66018511
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63793715
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.63120284
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.62988739
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62877555
107Oocyte meiosis_Homo sapiens_hsa041140.62483358
108Toxoplasmosis_Homo sapiens_hsa051450.62066199
109Basal cell carcinoma_Homo sapiens_hsa052170.59998484
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.56290681
111Influenza A_Homo sapiens_hsa051640.56031431
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55867733
113Viral carcinogenesis_Homo sapiens_hsa052030.53306330
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53122418
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52693646
116Circadian rhythm_Homo sapiens_hsa047100.50996647
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50493726
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49425547
119Herpes simplex infection_Homo sapiens_hsa051680.48624960
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47615009
121Hepatitis C_Homo sapiens_hsa051600.47439926
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45849383
123Systemic lupus erythematosus_Homo sapiens_hsa053220.45823461
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45558606
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.44995858
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44763641
127Acute myeloid leukemia_Homo sapiens_hsa052210.43058030
128Chronic myeloid leukemia_Homo sapiens_hsa052200.41979709
129TGF-beta signaling pathway_Homo sapiens_hsa043500.41608329
130Basal transcription factors_Homo sapiens_hsa030220.41218564
131Fat digestion and absorption_Homo sapiens_hsa049750.41057854
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.40090984
133Pyruvate metabolism_Homo sapiens_hsa006200.40088594
134Purine metabolism_Homo sapiens_hsa002300.40083872
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39725614
136Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39550651
137VEGF signaling pathway_Homo sapiens_hsa043700.39350982
138Lysine degradation_Homo sapiens_hsa003100.39264073
139Colorectal cancer_Homo sapiens_hsa052100.39149193
140Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38808518
141Small cell lung cancer_Homo sapiens_hsa052220.38670634
142Hepatitis B_Homo sapiens_hsa051610.38204275
143HTLV-I infection_Homo sapiens_hsa051660.37943728
144Jak-STAT signaling pathway_Homo sapiens_hsa046300.36420994
145Apoptosis_Homo sapiens_hsa042100.35715502
146Arginine biosynthesis_Homo sapiens_hsa002200.35430644
147Wnt signaling pathway_Homo sapiens_hsa043100.33988860
148Non-homologous end-joining_Homo sapiens_hsa034500.33717466
149Metabolic pathways_Homo sapiens_hsa011000.32758652
150AMPK signaling pathway_Homo sapiens_hsa041520.31053262
151Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30465143
152Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28999505
153N-Glycan biosynthesis_Homo sapiens_hsa005100.27270220
154Maturity onset diabetes of the young_Homo sapiens_hsa049500.23249258
155Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22991823
156Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22619841
157MicroRNAs in cancer_Homo sapiens_hsa052060.21344468

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