CHMP7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)6.63024130
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.63024130
3positive regulation of gamma-delta T cell activation (GO:0046645)6.45927940
4negative thymic T cell selection (GO:0045060)5.67767999
5negative T cell selection (GO:0043383)5.66987275
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.55333843
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.53545376
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.26797208
9antigen processing and presentation of endogenous antigen (GO:0019883)5.16870161
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.07660065
11regulation of B cell receptor signaling pathway (GO:0050855)4.97790411
12positive thymic T cell selection (GO:0045059)4.96873997
13thymic T cell selection (GO:0045061)4.95489949
14regulation of gamma-delta T cell differentiation (GO:0045586)4.89434460
15positive T cell selection (GO:0043368)4.82828769
16layer formation in cerebral cortex (GO:0021819)4.82491149
17T cell selection (GO:0045058)4.79623028
18regulation of gamma-delta T cell activation (GO:0046643)4.79580277
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.75618433
20leukocyte aggregation (GO:0070486)4.74901073
21synaptic vesicle maturation (GO:0016188)4.73629569
22positive regulation of synapse maturation (GO:0090129)4.46044186
23tolerance induction (GO:0002507)4.34523082
24positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.30583207
25regulation of short-term neuronal synaptic plasticity (GO:0048172)4.29180245
26NIK/NF-kappaB signaling (GO:0038061)4.26171870
27response to interleukin-15 (GO:0070672)4.25424764
28synaptic vesicle exocytosis (GO:0016079)4.03178524
29B cell receptor signaling pathway (GO:0050853)3.99908618
30T cell migration (GO:0072678)3.94841063
31pyrimidine nucleobase catabolic process (GO:0006208)3.91703987
32locomotory exploration behavior (GO:0035641)3.80179951
33negative regulation of T cell mediated immunity (GO:0002710)3.79305513
34glutamate secretion (GO:0014047)3.78955611
35negative regulation of lymphocyte mediated immunity (GO:0002707)3.76953250
36regulation of T cell tolerance induction (GO:0002664)3.72841178
37negative regulation of microtubule polymerization (GO:0031115)3.69874401
38cellular response to interleukin-15 (GO:0071350)3.69670044
39positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.68250878
40positive regulation of granulocyte differentiation (GO:0030854)3.67448579
41regulation of synaptic vesicle exocytosis (GO:2000300)3.61838874
42cell migration in hindbrain (GO:0021535)3.50966557
43positive regulation by symbiont of host defense response (GO:0052509)3.49895532
44modulation by symbiont of host defense response (GO:0052031)3.49895532
45modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.49895532
46modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.49895532
47positive regulation by organism of defense response of other organism involved in symbiotic interact3.49895532
48modulation by symbiont of host immune response (GO:0052553)3.49895532
49sodium ion export (GO:0071436)3.47066117
50regulation of B cell differentiation (GO:0045577)3.46941860
51regulation of synapse structural plasticity (GO:0051823)3.46910063
52activated T cell proliferation (GO:0050798)3.46663360
53negative regulation of leukocyte mediated immunity (GO:0002704)3.45719278
54regulation of alpha-beta T cell proliferation (GO:0046640)3.44912632
55negative regulation of erythrocyte differentiation (GO:0045647)3.44406535
56histone H3-K36 demethylation (GO:0070544)3.43535890
57detection of other organism (GO:0098543)3.41853983
58detection of bacterium (GO:0016045)3.40305618
59central nervous system myelination (GO:0022010)3.33091985
60axon ensheathment in central nervous system (GO:0032291)3.33091985
61positive regulation of B cell differentiation (GO:0045579)3.33077814
62response to muramyl dipeptide (GO:0032495)3.32424338
63activation of protein kinase A activity (GO:0034199)3.31604377
64alpha-linolenic acid metabolic process (GO:0036109)3.31254449
65negative regulation of interleukin-12 production (GO:0032695)3.31250799
66regulation of necroptotic process (GO:0060544)3.30281559
67neurotransmitter secretion (GO:0007269)3.29370829
68germinal center formation (GO:0002467)3.28523904
69synaptic vesicle docking involved in exocytosis (GO:0016081)3.28130657
70antigen receptor-mediated signaling pathway (GO:0050851)3.25506520
71positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.23510056
72negative regulation of glycoprotein biosynthetic process (GO:0010561)3.22238259
73positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.21696628
74regulation of T cell mediated cytotoxicity (GO:0001914)3.18229740
75T cell receptor signaling pathway (GO:0050852)3.17857115
76L-phenylalanine metabolic process (GO:0006558)3.17389683
77erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.17389683
78response to pheromone (GO:0019236)3.17320071
79cell communication by electrical coupling (GO:0010644)3.16011845
80regulation of interleukin-2 biosynthetic process (GO:0045076)3.15218987
81regulation of tolerance induction (GO:0002643)3.13762586
82regulation of natural killer cell mediated immunity (GO:0002715)3.13455156
83regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.13455156
84nucleobase catabolic process (GO:0046113)3.13325487
85vocalization behavior (GO:0071625)3.13139953
86T cell homeostasis (GO:0043029)3.11968429
87cerebellar Purkinje cell layer development (GO:0021680)3.11152044
88regulation of synaptic vesicle transport (GO:1902803)3.11126903
89erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.10389000
90L-phenylalanine catabolic process (GO:0006559)3.10389000
91regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.08591030
92neuromuscular process controlling balance (GO:0050885)3.08410526
93regulation of isotype switching to IgG isotypes (GO:0048302)3.07760280
94regulation of regulatory T cell differentiation (GO:0045589)3.06090210
95interferon-gamma production (GO:0032609)3.05922663
96establishment of mitochondrion localization (GO:0051654)3.02466808
97B cell homeostasis (GO:0001782)3.02105911
98protein localization to synapse (GO:0035418)3.01892070
99regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.00831471
100regulation of granulocyte differentiation (GO:0030852)2.99627766
101lung epithelium development (GO:0060428)2.99126084
102cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.99002323
103macrophage activation involved in immune response (GO:0002281)2.98801629
104regulation of defense response to virus by virus (GO:0050690)2.97949232
105epithelial cell differentiation involved in prostate gland development (GO:0060742)2.97867013
106regulation of synapse maturation (GO:0090128)2.97564568
107positive regulation of alpha-beta T cell proliferation (GO:0046641)2.96402462
108dendritic spine morphogenesis (GO:0060997)2.96078560
109lymphocyte homeostasis (GO:0002260)2.95018428
110response to laminar fluid shear stress (GO:0034616)2.94932504
111positive regulation of tolerance induction (GO:0002645)2.94607213
112dendrite morphogenesis (GO:0048813)2.94325573
113mating behavior (GO:0007617)2.94300684
114negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.93681625
115cellular extravasation (GO:0045123)2.93670312
116establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.93056212
117mitochondrion transport along microtubule (GO:0047497)2.93056212
118neutrophil activation involved in immune response (GO:0002283)2.92905851
119regulation of neuronal synaptic plasticity (GO:0048168)2.92096451
120type I interferon signaling pathway (GO:0060337)2.91990562
121cellular response to type I interferon (GO:0071357)2.91990562
122regulation of glutamate receptor signaling pathway (GO:1900449)2.91782133
123positive regulation of T cell mediated cytotoxicity (GO:0001916)2.88633496
124negative regulation of necroptotic process (GO:0060546)2.88183903
125response to type I interferon (GO:0034340)2.87925798
126gamma-aminobutyric acid transport (GO:0015812)2.87494420
127exploration behavior (GO:0035640)2.87385630
128neuromuscular process controlling posture (GO:0050884)2.87001512
129myeloid dendritic cell differentiation (GO:0043011)2.86600755
130lysine catabolic process (GO:0006554)2.86407489
131lysine metabolic process (GO:0006553)2.86407489
132glycine transport (GO:0015816)2.86131746
133respiratory burst (GO:0045730)2.85311801
134positive regulation of interleukin-2 production (GO:0032743)2.85282184
135regulation of dendritic cell antigen processing and presentation (GO:0002604)2.85076828
136negative regulation of phagocytosis (GO:0050765)2.83914845
137antigen processing and presentation via MHC class Ib (GO:0002475)2.83899308
138neuronal action potential propagation (GO:0019227)2.83541424
139defense response to protozoan (GO:0042832)2.81850097
140regulation of type I interferon-mediated signaling pathway (GO:0060338)2.81763835
141negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.80253754
142negative regulation of innate immune response (GO:0045824)2.79136014
143proline transport (GO:0015824)2.77961950
144regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.77069400
145myeloid dendritic cell activation (GO:0001773)2.76897273
146negative regulation of T-helper cell differentiation (GO:0045623)2.74359262
147negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.74359262
148organelle transport along microtubule (GO:0072384)2.73783575
149signal complex assembly (GO:0007172)2.73254748
150cellular response to interleukin-4 (GO:0071353)2.73253845
151cellular potassium ion homeostasis (GO:0030007)2.72998525
152negative regulation of type 2 immune response (GO:0002829)2.72280168
153regulation of long-term neuronal synaptic plasticity (GO:0048169)2.71171841
154regulation of leukocyte mediated cytotoxicity (GO:0001910)2.70210431
155regulation of alpha-beta T cell activation (GO:0046634)2.69824981
156alpha-beta T cell differentiation (GO:0046632)2.68925241
157natural killer cell differentiation (GO:0001779)2.65573355
158negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.65095479
159negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.64980652
160axon cargo transport (GO:0008088)2.64566725
161aspartate family amino acid catabolic process (GO:0009068)2.64238358
162macroautophagy (GO:0016236)2.64105935
163neuron recognition (GO:0008038)2.62920468
164negative regulation of cell size (GO:0045792)2.60629073
165vesicle transport along microtubule (GO:0047496)2.59048929
166dicarboxylic acid catabolic process (GO:0043649)2.57631796
167establishment of nucleus localization (GO:0040023)2.56965612
168neurotransmitter-gated ion channel clustering (GO:0072578)2.55700686
169CDP-diacylglycerol metabolic process (GO:0046341)2.55165260
170neuron cell-cell adhesion (GO:0007158)2.54828716
171neurotransmitter transport (GO:0006836)2.53089359
172glutamate metabolic process (GO:0006536)2.49879800
173regulation of dendritic spine morphogenesis (GO:0061001)2.49732431
174epithelial cell fate commitment (GO:0072148)2.49500160
175glyoxylate metabolic process (GO:0046487)2.49454606
176peptidyl-arginine omega-N-methylation (GO:0035247)2.46764362
177lens fiber cell development (GO:0070307)2.43127056
178axonal fasciculation (GO:0007413)2.43044988
179regulation of calcium ion-dependent exocytosis (GO:0017158)2.42459929
180regulation of neurotransmitter levels (GO:0001505)2.41273806
181cytoskeletal anchoring at plasma membrane (GO:0007016)2.38935843
182cellular sodium ion homeostasis (GO:0006883)2.38932569
183suckling behavior (GO:0001967)2.38696939
184cellular ketone body metabolic process (GO:0046950)2.38297524
185regulation of fatty acid beta-oxidation (GO:0031998)2.37079843
186dicarboxylic acid biosynthetic process (GO:0043650)2.37003424
187regulation of ARF protein signal transduction (GO:0032012)2.36723302
188detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.36317820
189detection of temperature stimulus involved in sensory perception (GO:0050961)2.36317820
190alanine transport (GO:0032328)2.35773947
191membrane repolarization (GO:0086009)2.35389978
192cell communication involved in cardiac conduction (GO:0086065)2.32298911
193axon extension (GO:0048675)2.31566775
194cerebellar granule cell differentiation (GO:0021707)2.31024213
195peptidyl-arginine methylation (GO:0018216)2.30012966
196peptidyl-arginine N-methylation (GO:0035246)2.30012966
1972-oxoglutarate metabolic process (GO:0006103)2.28491586
198negative regulation of potassium ion transmembrane transport (GO:1901380)2.26440267
199innervation (GO:0060384)2.25689588
200regulation of early endosome to late endosome transport (GO:2000641)2.25180629

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.67817958
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.38460073
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.97664441
4MYC_22102868_ChIP-Seq_BL_Human3.56008655
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.40255345
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.17147197
7EZH2_22144423_ChIP-Seq_EOC_Human3.08437934
8VDR_21846776_ChIP-Seq_THP-1_Human2.96236491
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.86526724
10RUNX_20019798_ChIP-Seq_JUKART_Human2.86200555
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.79438854
12ZNF263_19887448_ChIP-Seq_K562_Human2.77487692
13MAF_26560356_Chip-Seq_TH1_Human2.70174891
14* MYB_26560356_Chip-Seq_TH2_Human2.63272214
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.61455903
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.60648839
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.59355624
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.58366096
19UTX_26944678_Chip-Seq_JUKART_Human2.57521333
20ZFP281_18757296_ChIP-ChIP_E14_Mouse2.56440361
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.45927920
22ERG_21242973_ChIP-ChIP_JURKAT_Human2.41891006
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.41664262
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.41169486
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.36102666
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.35954890
27TCF7_22412390_ChIP-Seq_EML_Mouse2.33999920
28MYB_26560356_Chip-Seq_TH1_Human2.31137483
29BP1_19119308_ChIP-ChIP_Hs578T_Human2.29714875
30REST_18959480_ChIP-ChIP_MESCs_Mouse2.29364101
31MAF_26560356_Chip-Seq_TH2_Human2.27008988
32ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.26641970
33IRF8_21731497_ChIP-ChIP_J774_Mouse2.23957503
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.20036193
35REST_21632747_ChIP-Seq_MESCs_Mouse2.18472057
36MYB_21317192_ChIP-Seq_ERMYB_Mouse2.17597171
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.16816395
38STAT4_19710469_ChIP-ChIP_TH1__Mouse2.15951623
39RUNX1_22412390_ChIP-Seq_EML_Mouse2.15164475
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.14930331
41RXR_22158963_ChIP-Seq_LIVER_Mouse2.14175894
42SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.12983037
43IRF8_27001747_Chip-Seq_BMDM_Mouse2.06007898
44VDR_24763502_ChIP-Seq_THP-1_Human2.04816956
45EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02644372
46RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02644372
47EGR1_19374776_ChIP-ChIP_THP-1_Human2.00639886
48SPI1_23547873_ChIP-Seq_NB4_Human1.98666096
49DROSHA_22980978_ChIP-Seq_HELA_Human1.98364105
50SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.95671587
51BRD4_27068464_Chip-Seq_AML-cells_Mouse1.95355261
52PPARA_22158963_ChIP-Seq_LIVER_Mouse1.94689016
53DNAJC2_21179169_ChIP-ChIP_NT2_Human1.94286122
54NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.93774601
55EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.92491471
56MTF2_20144788_ChIP-Seq_MESCs_Mouse1.89994469
57LXR_22292898_ChIP-Seq_THP-1_Human1.89259014
58SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.88592515
59* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.87557529
60JARID2_20064375_ChIP-Seq_MESCs_Mouse1.87460874
61JARID2_20075857_ChIP-Seq_MESCs_Mouse1.87291057
62IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.86120808
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.84380710
64KDM2B_26808549_Chip-Seq_K562_Human1.84227586
65WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.83074660
66CIITA_25753668_ChIP-Seq_RAJI_Human1.82983146
67EZH2_27294783_Chip-Seq_ESCs_Mouse1.81199627
68TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.80442806
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79304673
70MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.76861736
71SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75327608
72SUZ12_27294783_Chip-Seq_ESCs_Mouse1.74768254
73SCL_19346495_ChIP-Seq_HPC-7_Human1.73260751
74FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.72621364
75ELF1_17652178_ChIP-ChIP_JURKAT_Human1.72065083
76SPI1_23127762_ChIP-Seq_K562_Human1.69089097
77EZH2_27304074_Chip-Seq_ESCs_Mouse1.65210928
78GATA3_27048872_Chip-Seq_THYMUS_Human1.65002769
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.59680853
80KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59319386
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.57886897
82SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.57788937
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.56405341
84CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.55623920
85ESR1_15608294_ChIP-ChIP_MCF-7_Human1.55294198
86ZFP281_27345836_Chip-Seq_ESCs_Mouse1.54654856
87SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.51025953
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50164177
89ESR2_21235772_ChIP-Seq_MCF-7_Human1.49646637
90KDM2B_26808549_Chip-Seq_DND41_Human1.48770046
91RNF2_27304074_Chip-Seq_ESCs_Mouse1.47925555
92LXR_22158963_ChIP-Seq_LIVER_Mouse1.45811034
93CLOCK_20551151_ChIP-Seq_293T_Human1.45127268
94RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.39659464
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39215831
96SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.38981147
97OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.38706729
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38017686
99GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37631732
100TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37103498
101CTCF_27219007_Chip-Seq_Bcells_Human1.36552445
102STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35031003
103DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.34648756
104TET1_21490601_ChIP-Seq_MESCs_Mouse1.33889625
105GATA2_22383799_ChIP-Seq_G1ME_Mouse1.33697883
106PU.1_20513432_ChIP-Seq_Bcells_Mouse1.30979294
107GATA1_19941827_ChIP-Seq_MEL_Mouse1.29871049
108* CREB1_26743006_Chip-Seq_LNCaP_Human1.29247059
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28927529
110TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.27260772
111RING1B_27294783_Chip-Seq_ESCs_Mouse1.26796994
112P300_27058665_Chip-Seq_ZR-75-30cells_Human1.26201694
113EED_16625203_ChIP-ChIP_MESCs_Mouse1.26090070
114GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25027259
115BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23164437
116ZNF274_21170338_ChIP-Seq_K562_Hela1.21813853
117ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.21736079
118SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20965419
119CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20654934
120SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20638310
121P68_20966046_ChIP-Seq_HELA_Human1.20321791
122SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20204157
123RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17934490
124SMAD_19615063_ChIP-ChIP_OVARY_Human1.17094845
125CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16900334
126SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14553691
127CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13693980
128PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13598216
129RACK7_27058665_Chip-Seq_MCF-7_Human1.13519050
130NCOR1_26117541_ChIP-Seq_K562_Human1.13486897
131SMC4_20622854_ChIP-Seq_HELA_Human1.13481482
132PU_27001747_Chip-Seq_BMDM_Mouse1.13291886
133SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.12925629
134NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.11731004
135* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11148112
136LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10562458
137* KDM2B_26808549_Chip-Seq_JURKAT_Human1.09420732
138NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06616806
139TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06033933
140* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05422870
141MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04287912
142GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.04287722
143NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04235067
144* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04068511
145KLF4_19829295_ChIP-Seq_ESCs_Human1.03863058
146WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03492126
147CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03072386
148* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00543222
149* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00326732
150GATA3_26560356_Chip-Seq_TH2_Human1.00081511
151BCOR_27268052_Chip-Seq_Bcells_Human1.00035822
152EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.98780280
153CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98185671
154BCL6_27268052_Chip-Seq_Bcells_Human0.98023444
155RING1B_27294783_Chip-Seq_NPCs_Mouse0.96417517
156UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95865068
157SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95778840
158TET1_21451524_ChIP-Seq_MESCs_Mouse0.95446818
159SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95434394
160SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.95031792
161TP53_20018659_ChIP-ChIP_R1E_Mouse0.94765616
162RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.94719743
163DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94273987
164TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.94206450
165MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.93996238
166POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93890975
167* ELK3_25401928_ChIP-Seq_HUVEC_Human0.93784713
168TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.93190724
169TFEB_21752829_ChIP-Seq_HELA_Human0.92441081
170* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.91796506
171SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.91288444
172NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90796443
173SOX2_21211035_ChIP-Seq_LN229_Gbm0.90684153
174STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90011804
175ELF1_20517297_ChIP-Seq_JURKAT_Human0.89755810
176ETS1_21867929_ChIP-Seq_TH2_Mouse0.88634899
177LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88533859
178* FOXP1_21924763_ChIP-Seq_HESCs_Human0.88285054
179SA1_27219007_Chip-Seq_ERYTHROID_Human0.87965941
180FOXA2_19822575_ChIP-Seq_HepG2_Human0.87784990
181NOTCH1_21737748_ChIP-Seq_TLL_Human0.86572382
182GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.86120199
183ERG_20887958_ChIP-Seq_HPC-7_Mouse0.83871864
184KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.83822538

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.78446714
2MP0003763_abnormal_thymus_physiology4.49848446
3MP0003436_decreased_susceptibility_to3.96090967
4MP0003880_abnormal_central_pattern3.78176250
5MP0009780_abnormal_chondrocyte_physiolo3.53006556
6MP0004270_analgesia3.36688537
7MP0003724_increased_susceptibility_to3.24392249
8MP0003300_gastrointestinal_ulcer3.07988165
9MP0001800_abnormal_humoral_immune3.06843595
10MP0003303_peritoneal_inflammation3.05468980
11MP0001835_abnormal_antigen_presentation3.02926712
12MP0005423_abnormal_somatic_nervous2.91892530
13MP0005671_abnormal_response_to2.89420170
14MP0003635_abnormal_synaptic_transmissio2.87684354
15MP0003329_amyloid_beta_deposits2.87160928
16MP0005000_abnormal_immune_tolerance2.79837389
17MP0008260_abnormal_autophagy2.67872553
18MP0005451_abnormal_body_composition2.61745062
19MP0005387_immune_system_phenotype2.57680346
20MP0001790_abnormal_immune_system2.57680346
21MP0002420_abnormal_adaptive_immunity2.55989822
22MP0009333_abnormal_splenocyte_physiolog2.54399689
23MP0002139_abnormal_hepatobiliary_system2.52867912
24MP0001819_abnormal_immune_cell2.51976025
25MP0002723_abnormal_immune_serum2.51795288
26MP0002452_abnormal_antigen_presenting2.46425608
27MP0005025_abnormal_response_to2.40116752
28MP0002837_dystrophic_cardiac_calcinosis2.39558252
29MP0000685_abnormal_immune_system2.39240463
30MP0002909_abnormal_adrenal_gland2.33743233
31MP0002419_abnormal_innate_immunity2.31625075
32MP0002398_abnormal_bone_marrow2.29948924
33MP0004858_abnormal_nervous_system2.28165584
34MP0002063_abnormal_learning/memory/cond2.22030084
35MP0000703_abnormal_thymus_morphology2.20437745
36MP0010155_abnormal_intestine_physiology2.11191207
37MP0000716_abnormal_immune_system2.09063411
38MP0009785_altered_susceptibility_to2.06111741
39MP0002064_seizures2.02763281
40MP0002405_respiratory_system_inflammati2.01230337
41MP0005360_urolithiasis1.98688968
42MP0004947_skin_inflammation1.96124407
43MP0000689_abnormal_spleen_morphology1.92163943
44MP0002722_abnormal_immune_system1.90937339
45MP0001873_stomach_inflammation1.88850544
46MP0009745_abnormal_behavioral_response1.86541075
47MP0004885_abnormal_endolymph1.86418922
48MP0002734_abnormal_mechanical_nocicepti1.85771688
49MP0005365_abnormal_bile_salt1.85087100
50MP0003866_abnormal_defecation1.83844530
51MP0008961_abnormal_basal_metabolism1.83292725
52MP0003705_abnormal_hypodermis_morpholog1.82003920
53MP0003191_abnormal_cellular_cholesterol1.80718034
54MP0002822_catalepsy1.80165464
55MP0000465_gastrointestinal_hemorrhage1.78743554
56MP0001968_abnormal_touch/_nociception1.77129894
57MP0004381_abnormal_hair_follicle1.76780800
58MP0002148_abnormal_hypersensitivity_rea1.76623393
59MP0005464_abnormal_platelet_physiology1.76608920
60MP0009840_abnormal_foam_cell1.76428360
61MP0005083_abnormal_biliary_tract1.75495712
62MP0002009_preneoplasia1.72254835
63MP0000537_abnormal_urethra_morphology1.72221128
64MP0005310_abnormal_salivary_gland1.71918296
65MP0000778_abnormal_nervous_system1.71700612
66MP0001533_abnormal_skeleton_physiology1.70410008
67MP0002429_abnormal_blood_cell1.69254776
68MP0000955_abnormal_spinal_cord1.68091762
69MP0004130_abnormal_muscle_cell1.63928895
70MP0005085_abnormal_gallbladder_physiolo1.63543719
71MP0006082_CNS_inflammation1.62502110
72MP0004811_abnormal_neuron_physiology1.62468201
73MP0002572_abnormal_emotion/affect_behav1.59956962
74MP0004233_abnormal_muscle_weight1.59279787
75MP0003183_abnormal_peptide_metabolism1.57912598
76MP0000604_amyloidosis1.54225000
77MP0001845_abnormal_inflammatory_respons1.54121826
78MP0000747_muscle_weakness1.53659226
79MP0002653_abnormal_ependyma_morphology1.52433545
80MP0002733_abnormal_thermal_nociception1.51860883
81MP0003172_abnormal_lysosome_physiology1.51701102
82MP0002396_abnormal_hematopoietic_system1.49902433
83MP0005187_abnormal_penis_morphology1.49513575
84MP0002272_abnormal_nervous_system1.49280635
85MP0009046_muscle_twitch1.47309959
86MP0000013_abnormal_adipose_tissue1.47173053
87MP0009278_abnormal_bone_marrow1.45723017
88MP0002184_abnormal_innervation1.44504622
89MP0001440_abnormal_grooming_behavior1.44489519
90MP0000751_myopathy1.42364507
91MP0006276_abnormal_autonomic_nervous1.42335900
92MP0000858_altered_metastatic_potential1.41847847
93MP0003828_pulmonary_edema1.40100821
94MP0003283_abnormal_digestive_organ1.39696675
95MP0001486_abnormal_startle_reflex1.37418593
96MP0002933_joint_inflammation1.36067589
97MP0005386_behavior/neurological_phenoty1.32859822
98MP0004924_abnormal_behavior1.32859822
99MP0004145_abnormal_muscle_electrophysio1.32566329
100MP0001853_heart_inflammation1.31189106
101MP0002138_abnormal_hepatobiliary_system1.30066649
102MP0010329_abnormal_lipoprotein_level1.29418558
103MP0005058_abnormal_lysosome_morphology1.26656807
104MP0001851_eye_inflammation1.25662348
105MP0001970_abnormal_pain_threshold1.25615333
106MP0002166_altered_tumor_susceptibility1.24705873
107MP0008569_lethality_at_weaning1.23848114
108MP0004510_myositis1.21568552
109MP0000490_abnormal_crypts_of1.20497417
110MP0002735_abnormal_chemical_nociception1.18294917
111MP0002066_abnormal_motor_capabilities/c1.16951538
112MP0003091_abnormal_cell_migration1.14842067
113MP0002882_abnormal_neuron_morphology1.14786767
114MP0002234_abnormal_pharynx_morphology1.14265608
115MP0008469_abnormal_protein_level1.13253835
116MP0002067_abnormal_sensory_capabilities1.12906863
117MP0002736_abnormal_nociception_after1.12906667
118MP0002998_abnormal_bone_remodeling1.11342667
119MP0005332_abnormal_amino_acid1.10667923
120MP0003633_abnormal_nervous_system1.10331281
121MP0005075_abnormal_melanosome_morpholog1.08636752
122MP0002269_muscular_atrophy1.08632675
123MP0003137_abnormal_impulse_conducting1.07116872
124MP0001299_abnormal_eye_distance/1.06667271
125MP0010030_abnormal_orbit_morphology1.06390535
126MP0004185_abnormal_adipocyte_glucose1.04756512
127MP0003634_abnormal_glial_cell1.03851321
128MP0001348_abnormal_lacrimal_gland1.02514343
129MP0002132_abnormal_respiratory_system1.01499936
130MP0008875_abnormal_xenobiotic_pharmacok1.01384863
131MP0002152_abnormal_brain_morphology1.00119033
132MP0000003_abnormal_adipose_tissue0.98573382
133MP0004808_abnormal_hematopoietic_stem0.97580280
134MP0002006_tumorigenesis0.97395330
135MP0004036_abnormal_muscle_relaxation0.96282382
136MP0002089_abnormal_postnatal_growth/wei0.95034381
137MP0002557_abnormal_social/conspecific_i0.94584871
138MP0003879_abnormal_hair_cell0.92831896
139MP0009764_decreased_sensitivity_to0.91425119
140MP0003448_altered_tumor_morphology0.91035582
141MP0001529_abnormal_vocalization0.89499893
142MP0001663_abnormal_digestive_system0.88658380
143MP0003631_nervous_system_phenotype0.88445311
144MP0002118_abnormal_lipid_homeostasis0.88371608
145MP0003806_abnormal_nucleotide_metabolis0.87155139
146MP0004883_abnormal_blood_vessel0.86664925
147MP0002069_abnormal_eating/drinking_beha0.86661472
148MP0001501_abnormal_sleep_pattern0.84383541
149MP0004215_abnormal_myocardial_fiber0.82767692
150MP0002229_neurodegeneration0.80227937
151MP0003119_abnormal_digestive_system0.79566749
152MP0001545_abnormal_hematopoietic_system0.79417523
153MP0005397_hematopoietic_system_phenotyp0.79417523
154MP0004142_abnormal_muscle_tone0.79225001
155MP0003221_abnormal_cardiomyocyte_apopto0.78938419
156MP0002090_abnormal_vision0.78430247
157MP0005535_abnormal_body_temperature0.78029592
158MP0008874_decreased_physiological_sensi0.78011528
159MP0002019_abnormal_tumor_incidence0.77598750
160MP0010234_abnormal_vibrissa_follicle0.76901480
161MP0003690_abnormal_glial_cell0.76122805
162MP0003656_abnormal_erythrocyte_physiolo0.74411405
163MP0004085_abnormal_heartbeat0.74100356
164MP0002254_reproductive_system_inflammat0.73379770
165MP0005621_abnormal_cell_physiology0.72920405
166MP0002078_abnormal_glucose_homeostasis0.72723672
167MP0009763_increased_sensitivity_to0.71302573
168MP0004084_abnormal_cardiac_muscle0.70625240
169MP0003861_abnormal_nervous_system0.70503852
170MP0004087_abnormal_muscle_fiber0.69717137
171MP0001666_abnormal_nutrient_absorption0.69563493
172MP0005220_abnormal_exocrine_pancreas0.67730375
173MP0003632_abnormal_nervous_system0.66698602
174MP0002332_abnormal_exercise_endurance0.66425790
175MP0005166_decreased_susceptibility_to0.66370345
176MP0000249_abnormal_blood_vessel0.65173826
177MP0005375_adipose_tissue_phenotype0.64704598
178MP0006035_abnormal_mitochondrial_morpho0.64327492
179MP0003453_abnormal_keratinocyte_physiol0.64293400
180MP0005666_abnormal_adipose_tissue0.64239254
181MP0005390_skeleton_phenotype0.63642354
182MP0008004_abnormal_stomach_pH0.63620781
183MP0002877_abnormal_melanocyte_morpholog0.62848001
184MP0003195_calcinosis0.62801803
185MP0003795_abnormal_bone_structure0.62178350
186MP0000569_abnormal_digit_pigmentation0.61832786
187MP0003279_aneurysm0.60119597
188MP0005076_abnormal_cell_differentiation0.58652927
189MP0003045_fibrosis0.55585742
190MP0009765_abnormal_xenobiotic_induced0.53920038

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.00210298
2T lymphocytopenia (HP:0005403)4.59170541
3Myokymia (HP:0002411)4.52802580
4Elevated erythrocyte sedimentation rate (HP:0003565)4.12655006
5Recurrent bacterial skin infections (HP:0005406)4.10193417
6Recurrent abscess formation (HP:0002722)4.08252349
7Stomatitis (HP:0010280)4.07842794
8Myositis (HP:0100614)4.04898749
9Abnormality of T cell number (HP:0011839)3.99497326
10Panhypogammaglobulinemia (HP:0003139)3.84488301
11Pustule (HP:0200039)3.81012209
12Recurrent fungal infections (HP:0002841)3.71615130
13Abnormality of the lower motor neuron (HP:0002366)3.68567049
14Mediastinal lymphadenopathy (HP:0100721)3.63793309
15Abnormality of macrophages (HP:0004311)3.60705544
16Cerebral inclusion bodies (HP:0100314)3.54464140
17Supranuclear gaze palsy (HP:0000605)3.53133175
18Abnormal delayed hypersensitivity skin test (HP:0002963)3.51861295
19Neurofibrillary tangles (HP:0002185)3.50323382
20Orchitis (HP:0100796)3.49471596
21Visual hallucinations (HP:0002367)3.49320363
22Spontaneous hematomas (HP:0007420)3.46716006
23Meningitis (HP:0001287)3.46021530
24Recurrent viral infections (HP:0004429)3.39288773
25Cellulitis (HP:0100658)3.29194558
26Gastrointestinal infarctions (HP:0005244)3.24426739
27Optic neuritis (HP:0100653)3.23925209
28Retrobulbar optic neuritis (HP:0100654)3.23925209
29Lymphopenia (HP:0001888)3.17488771
30Abnormality of T cells (HP:0002843)3.14246554
31Gastrointestinal inflammation (HP:0004386)3.13625972
32Megalencephaly (HP:0001355)3.12276666
33Vasculitis (HP:0002633)3.06336696
34Inflammation of the large intestine (HP:0002037)3.05808035
35Ankle clonus (HP:0011448)3.04128867
36Verrucae (HP:0200043)3.03079122
37Papilloma (HP:0012740)3.03079122
38Severe combined immunodeficiency (HP:0004430)3.02989545
39Abnormality of aromatic amino acid family metabolism (HP:0004338)3.02801988
40Chronic obstructive pulmonary disease (HP:0006510)3.02154148
41Obstructive lung disease (HP:0006536)3.02154148
42Colitis (HP:0002583)3.00304774
43Encephalitis (HP:0002383)2.98758331
44Insidious onset (HP:0003587)2.98721761
45Termporal pattern (HP:0011008)2.98721761
46Amyotrophic lateral sclerosis (HP:0007354)2.94125221
47Focal seizures (HP:0007359)2.93903552
48Agammaglobulinemia (HP:0004432)2.93433054
49Abnormality of cells of the lymphoid lineage (HP:0012140)2.91975978
50Slow saccadic eye movements (HP:0000514)2.81384971
51Gastrointestinal stroma tumor (HP:0100723)2.78627277
52Urinary urgency (HP:0000012)2.76657158
53Granulocytopenia (HP:0001913)2.76480717
54Chronic mucocutaneous candidiasis (HP:0002728)2.75921849
55Recurrent cutaneous fungal infections (HP:0011370)2.75921849
56Increased IgE level (HP:0003212)2.75637635
57Recurrent skin infections (HP:0001581)2.72962001
58Gingivitis (HP:0000230)2.72609635
59Recurrent gram-negative bacterial infections (HP:0005420)2.71284200
60Focal motor seizures (HP:0011153)2.69491100
61Pheochromocytoma (HP:0002666)2.69226733
62Deep venous thrombosis (HP:0002625)2.67953100
63Leukocytosis (HP:0001974)2.64213405
64Chest pain (HP:0100749)2.62829909
65Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.55103671
66Prolonged bleeding time (HP:0003010)2.54869344
67Combined immunodeficiency (HP:0005387)2.54070329
68IgG deficiency (HP:0004315)2.51072643
69Increased IgM level (HP:0003496)2.50105500
70Insomnia (HP:0100785)2.47692405
71Spastic gait (HP:0002064)2.47092420
72IgM deficiency (HP:0002850)2.46521881
73Keratoconjunctivitis sicca (HP:0001097)2.45337823
74Depression (HP:0000716)2.44536876
75Ketosis (HP:0001946)2.44251646
76Fatigue (HP:0012378)2.43506869
77Pulmonary infiltrates (HP:0002113)2.43443750
78Impaired social interactions (HP:0000735)2.36446165
79Abnormal social behavior (HP:0012433)2.36446165
80Impaired vibration sensation in the lower limbs (HP:0002166)2.35740267
81Torticollis (HP:0000473)2.34620764
82Epistaxis (HP:0000421)2.33372544
83Gout (HP:0001997)2.32782657
84Papilledema (HP:0001085)2.29954751
85Viral hepatitis (HP:0006562)2.29884542
86Upper limb amyotrophy (HP:0009129)2.28726172
87Distal upper limb amyotrophy (HP:0007149)2.28726172
88Basal cell carcinoma (HP:0002671)2.26615735
89Eosinophilia (HP:0001880)2.26245312
90Subacute progressive viral hepatitis (HP:0006572)2.26021621
91Urticaria (HP:0001025)2.25880293
92Sepsis (HP:0100806)2.25013628
93Osteomyelitis (HP:0002754)2.24894010
94Action tremor (HP:0002345)2.24351042
95Hand muscle atrophy (HP:0009130)2.23741799
96Abnormality of eosinophils (HP:0001879)2.23561532
97Abnormality of the Achilles tendon (HP:0005109)2.23144183
98Ketoacidosis (HP:0001993)2.22901747
99Hypoplasia of the thymus (HP:0000778)2.21666527
100Mutism (HP:0002300)2.20081067
101Keratoconjunctivitis (HP:0001096)2.19856950
102Poor eye contact (HP:0000817)2.19346237
103Neuroendocrine neoplasm (HP:0100634)2.16642026
104Segmental peripheral demyelination/remyelination (HP:0003481)2.15642494
105Hemoptysis (HP:0002105)2.15245408
106Craniofacial dystonia (HP:0012179)2.13977866
107Generalized tonic-clonic seizures (HP:0002069)2.13890380
108Abnormality of T cell physiology (HP:0011840)2.13717474
109Abnormality of the corticospinal tract (HP:0002492)2.13023286
110Focal dystonia (HP:0004373)2.12904189
111Recurrent bronchitis (HP:0002837)2.12620752
112Achilles tendon contracture (HP:0001771)2.12589740
113Hypsarrhythmia (HP:0002521)2.11789265
114Chronic diarrhea (HP:0002028)2.11387584
115Centrally nucleated skeletal muscle fibers (HP:0003687)2.10995935
116Morphological abnormality of the pyramidal tract (HP:0002062)2.10303718
117Difficulty running (HP:0009046)2.09797972
118Clonus (HP:0002169)2.09740404
119Xanthomatosis (HP:0000991)2.08187690
120EEG with generalized epileptiform discharges (HP:0011198)2.07247241
121Autoimmune hemolytic anemia (HP:0001890)2.04236575
122Lower limb muscle weakness (HP:0007340)2.03584300
123Lymphoma (HP:0002665)2.02666854
124Rapidly progressive (HP:0003678)2.01493422
125Hyperglycinemia (HP:0002154)2.00953002
126Teleangiectasia of the skin (HP:0100585)1.99573000
127Petechiae (HP:0000967)1.99029334
128Epileptiform EEG discharges (HP:0011182)1.98241099
129Absence seizures (HP:0002121)1.97603304
130Hematochezia (HP:0002573)1.97036534
131Restrictive lung disease (HP:0002091)1.96206492
132Neuronal loss in central nervous system (HP:0002529)1.96111866
133Postural instability (HP:0002172)1.95621314
134Limb dystonia (HP:0002451)1.94769330
135Pulmonary embolism (HP:0002204)1.94675114
136Abnormality of the fingertips (HP:0001211)1.93245382
137Acute hepatic failure (HP:0006554)1.93139234
138Turricephaly (HP:0000262)1.92544217
139Hypergammaglobulinemia (HP:0010702)1.92535606
140Cerebral hypomyelination (HP:0006808)1.91590499
141Spastic diplegia (HP:0001264)1.91449605
142Peripheral hypomyelination (HP:0007182)1.91347566
143Neonatal onset (HP:0003623)1.90850240
144Abnormality of serine family amino acid metabolism (HP:0010894)1.89667378
145Abnormality of glycine metabolism (HP:0010895)1.89667378
146Status epilepticus (HP:0002133)1.89638593
147Intention tremor (HP:0002080)1.89620803
148Interstitial pulmonary disease (HP:0006530)1.89400796
149Ventricular fibrillation (HP:0001663)1.89306985
150Pointed chin (HP:0000307)1.89081888
151Dysmetria (HP:0001310)1.88661478
152Bundle branch block (HP:0011710)1.88626797
153Epileptic encephalopathy (HP:0200134)1.87943306
154Delusions (HP:0000746)1.87858909
155Abnormal eating behavior (HP:0100738)1.87854755
156Resting tremor (HP:0002322)1.87202142
157Emphysema (HP:0002097)1.86968669
158Urinary bladder sphincter dysfunction (HP:0002839)1.85937255
159Global brain atrophy (HP:0002283)1.85591103
160Impaired pain sensation (HP:0007328)1.85427021
161Abnormality of pain sensation (HP:0010832)1.85427021
162Rigidity (HP:0002063)1.85020825
163Gingival bleeding (HP:0000225)1.84805116
164Atonic seizures (HP:0010819)1.84569302
165Neoplasm of the peripheral nervous system (HP:0100007)1.84519829
166Glomerulopathy (HP:0100820)1.84259266
167Hemiplegia (HP:0002301)1.83927637
168Loss of speech (HP:0002371)1.83561269
169Skin ulcer (HP:0200042)1.81512592
170Dialeptic seizures (HP:0011146)1.80692575
171Hyperammonemia (HP:0001987)1.80018376
172Dysdiadochokinesis (HP:0002075)1.79862984
173Exercise-induced myalgia (HP:0003738)1.79178954
174Anxiety (HP:0000739)1.79064912
175Alacrima (HP:0000522)1.78346353
176Abnormal neuron morphology (HP:0012757)1.78177841
177Abnormality of the motor neurons (HP:0002450)1.78177841
178IgA deficiency (HP:0002720)1.77935814
179Abnormality of the peritoneum (HP:0002585)1.77589912
180Shoulder girdle muscle weakness (HP:0003547)1.77245874
181Episodic fever (HP:0001954)1.77053550
182Spastic tetraparesis (HP:0001285)1.77021001
183Hammertoe (HP:0001765)1.76625069
184Dislocated radial head (HP:0003083)1.75778549
185Spinal cord lesions (HP:0100561)1.75223129
186Syringomyelia (HP:0003396)1.75223129
187Bradykinesia (HP:0002067)1.74893526
188Muscular hypotonia of the trunk (HP:0008936)1.74875795
189Coronal craniosynostosis (HP:0004440)1.74653807
190Hyperacusis (HP:0010780)1.74308470
191Athetosis (HP:0002305)1.74077042
192Increased variability in muscle fiber diameter (HP:0003557)1.73977396
193Apathy (HP:0000741)1.73652120
194Thickened helices (HP:0000391)1.73400394
195Anorexia (HP:0002039)1.72747516
196Arterial thrombosis (HP:0004420)1.72588308
197Drooling (HP:0002307)1.72547087
198Excessive salivation (HP:0003781)1.72547087
199Hyperlipoproteinemia (HP:0010980)1.72466072
200Abnormal platelet volume (HP:0011876)1.70150980

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.36959996
2MARK13.81782000
3MAP3K93.62957068
4PRPF4B3.54852938
5TRIB33.19352718
6KSR22.81738695
7RIPK42.65547570
8TXK2.60937037
9NTRK12.40677283
10NTRK32.38283881
11MINK12.26321080
12BCKDK2.24114219
13PKN22.21991307
14PAK62.21884717
15KSR12.21498792
16TYK22.20677049
17MAP2K32.14361249
18ZAP702.09398964
19MAP3K132.02016528
20GRK62.01586531
21DAPK22.00344532
22BLK1.94127639
23MAP3K41.93099518
24FES1.92473462
25CAMKK11.90179254
26CSK1.88319336
27JAK31.82194398
28IRAK41.81345456
29SCYL21.81194786
30ITK1.79600236
31EPHA41.78083232
32MAP3K141.78022509
33BTK1.74368679
34PRKD31.65267897
35IKBKE1.63693423
36EPHB11.55970539
37BUB11.53671505
38PHKG21.51133114
39PHKG11.51133114
40LATS21.50165512
41CDK191.48052360
42TYRO31.46016128
43SIK21.45332614
44MAP2K41.43500339
45RET1.42153988
46UHMK11.40680961
47HCK1.40039196
48MAP3K111.37030090
49NTRK21.36599775
50JAK11.35787244
51CDK121.34378377
52SYK1.31314774
53SMG11.30956110
54MARK31.30312447
55EPHB21.28869431
56TNK21.28628127
57SIK11.26695434
58LCK1.23956907
59NLK1.22799527
60TBK11.21943050
61CDK51.20319538
62NEK11.19365384
63MAP3K31.15857528
64MAP3K21.14997414
65STK101.13943046
66CSNK1G21.12117364
67ICK1.11576160
68PDGFRA1.11329324
69LIMK11.10720002
70DAPK11.08889004
71PAK31.08387058
72LMTK21.07546965
73TAOK11.05333594
74EEF2K1.01583365
75ARAF1.01448118
76CDK140.98270573
77LYN0.94941858
78TAOK20.94080219
79MAP3K100.94071347
80RIPK10.90978283
81FGFR30.90400164
82JAK20.90105774
83CDK180.89447298
84CDK150.89194038
85CDK40.89052615
86TAOK30.87660266
87TEC0.87525970
88STK380.85080499
89DYRK20.83713437
90ALK0.80128905
91RAF10.79685763
92PDK40.78860842
93PDK30.78860842
94MAPKAPK30.78496039
95FGFR10.78085087
96PRKCZ0.77943185
97FGR0.77803780
98CSF1R0.77533687
99CDC42BPA0.76961998
100CSNK1G30.76740572
101DYRK1B0.76052840
102CDK11A0.76003806
103MARK20.75226665
104TGFBR20.75034890
105CDK60.74216371
106HIPK20.73947311
107PASK0.73130651
108MAPK110.72922059
109IRAK10.71488311
110PIM10.70609776
111PRKD20.69863288
112FER0.69390202
113IKBKB0.69149136
114PRKCG0.68354038
115MELK0.67382184
116LRRK20.66255756
117BRD40.64959901
118STK110.64331535
119EPHA30.64245269
120IRAK30.63773386
121MAP2K10.63043063
122MAP3K70.62971861
123SIK30.61904749
124DAPK30.60412326
125IRAK20.60150713
126MAPK70.59778752
127PDPK10.59697004
128MAPK130.58557343
129CSNK1A1L0.57531216
130ERN10.56167468
131WNK30.55446288
132TTN0.54278596
133PTK20.54268233
134ROCK20.54027915
135ILK0.53644829
136FGFR20.51870450
137PDK10.48967327
138PRKCQ0.48868940
139FYN0.48407209
140MAP3K10.47104590
141MTOR0.47029611
142PTK60.46631162
143FGFR40.46585838
144PRKCH0.46515191
145CAMK40.45671271
146CLK10.45485273
147SGK4940.44988731
148SGK2230.44988731
149GRK50.44461438
150MAP3K80.44390172
151PNCK0.44236555
152BRSK10.43576114
153MAP2K70.42480687
154TESK20.41657146
155RPS6KC10.40612493
156RPS6KL10.40612493
157NEK60.40118280
158MAPK120.40106864
159CSNK1G10.39982877
160PINK10.39724032
161OXSR10.39507677
162ERBB20.38734741
163YES10.38573299
164RPS6KA30.38307291
165BCR0.38146231
166PRKAA10.38099203
167TESK10.38094093
168CAMKK20.37598373
169NME20.36894893
170KDR0.35760098

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.94068171
2Primary immunodeficiency_Homo sapiens_hsa053403.17605925
3B cell receptor signaling pathway_Homo sapiens_hsa046622.61048177
4T cell receptor signaling pathway_Homo sapiens_hsa046602.56258855
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.48155975
6Osteoclast differentiation_Homo sapiens_hsa043802.45374177
7Acute myeloid leukemia_Homo sapiens_hsa052212.32215677
8Synaptic vesicle cycle_Homo sapiens_hsa047212.27536461
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.22968075
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.19859138
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.09786007
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.08054583
13Primary bile acid biosynthesis_Homo sapiens_hsa001202.05886858
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.03318949
15Leishmaniasis_Homo sapiens_hsa051402.00577095
16Allograft rejection_Homo sapiens_hsa053301.94776724
17Arginine biosynthesis_Homo sapiens_hsa002201.90503548
18Butanoate metabolism_Homo sapiens_hsa006501.87437142
19Autoimmune thyroid disease_Homo sapiens_hsa053201.86850148
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.85671063
21Graft-versus-host disease_Homo sapiens_hsa053321.84684786
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.83689789
23Measles_Homo sapiens_hsa051621.83180892
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.82136329
25Non-small cell lung cancer_Homo sapiens_hsa052231.80690184
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.76364575
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.67350179
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.66637672
29GABAergic synapse_Homo sapiens_hsa047271.65056850
30Viral myocarditis_Homo sapiens_hsa054161.61321423
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.55861775
32Hematopoietic cell lineage_Homo sapiens_hsa046401.55011170
33Chronic myeloid leukemia_Homo sapiens_hsa052201.54442546
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.52838488
35Other glycan degradation_Homo sapiens_hsa005111.49355713
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47907136
37Hepatitis B_Homo sapiens_hsa051611.47538447
38Tuberculosis_Homo sapiens_hsa051521.46701673
39Pancreatic cancer_Homo sapiens_hsa052121.45086870
40Toxoplasmosis_Homo sapiens_hsa051451.44436923
41Herpes simplex infection_Homo sapiens_hsa051681.44050211
42TNF signaling pathway_Homo sapiens_hsa046681.43417435
43Nicotine addiction_Homo sapiens_hsa050331.40726187
44Long-term potentiation_Homo sapiens_hsa047201.40271521
45Dopaminergic synapse_Homo sapiens_hsa047281.39721943
46Chemokine signaling pathway_Homo sapiens_hsa040621.38026552
47Circadian entrainment_Homo sapiens_hsa047131.37972376
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.36857758
49Jak-STAT signaling pathway_Homo sapiens_hsa046301.36642601
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36026600
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34235788
52NOD-like receptor signaling pathway_Homo sapiens_hsa046211.34040672
53Fatty acid degradation_Homo sapiens_hsa000711.33989107
54Antigen processing and presentation_Homo sapiens_hsa046121.32043786
55Fatty acid metabolism_Homo sapiens_hsa012121.31764474
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.30872253
57Influenza A_Homo sapiens_hsa051641.30593759
58Amphetamine addiction_Homo sapiens_hsa050311.29104714
59Insulin secretion_Homo sapiens_hsa049111.27626543
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.27396829
61Propanoate metabolism_Homo sapiens_hsa006401.26667112
62Bile secretion_Homo sapiens_hsa049761.23919206
63Type I diabetes mellitus_Homo sapiens_hsa049401.23463295
64Colorectal cancer_Homo sapiens_hsa052101.21991161
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.21951769
66Leukocyte transendothelial migration_Homo sapiens_hsa046701.21366265
67Biosynthesis of amino acids_Homo sapiens_hsa012301.20624252
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20312420
69Olfactory transduction_Homo sapiens_hsa047401.20173877
70Glutamatergic synapse_Homo sapiens_hsa047241.19830036
71Prion diseases_Homo sapiens_hsa050201.19745266
72Staphylococcus aureus infection_Homo sapiens_hsa051501.18666984
73Cocaine addiction_Homo sapiens_hsa050301.18399695
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.16799434
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15960538
76Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.13772912
77Hepatitis C_Homo sapiens_hsa051601.13200252
78Carbon metabolism_Homo sapiens_hsa012001.13177479
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12847640
80Gap junction_Homo sapiens_hsa045401.11600348
81Apoptosis_Homo sapiens_hsa042101.09731906
82Morphine addiction_Homo sapiens_hsa050321.09619542
83Intestinal immune network for IgA production_Homo sapiens_hsa046721.08187916
84Viral carcinogenesis_Homo sapiens_hsa052031.07890034
85Epstein-Barr virus infection_Homo sapiens_hsa051691.05465131
86HTLV-I infection_Homo sapiens_hsa051661.05098155
87Dorso-ventral axis formation_Homo sapiens_hsa043201.04509324
88Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03408746
89Vitamin B6 metabolism_Homo sapiens_hsa007501.03303582
90Gastric acid secretion_Homo sapiens_hsa049711.03001367
91Cholinergic synapse_Homo sapiens_hsa047251.02559079
92Pyruvate metabolism_Homo sapiens_hsa006201.02456437
93FoxO signaling pathway_Homo sapiens_hsa040681.01815130
94Platelet activation_Homo sapiens_hsa046111.01586892
95Type II diabetes mellitus_Homo sapiens_hsa049301.01027948
96Malaria_Homo sapiens_hsa051440.98561912
97Shigellosis_Homo sapiens_hsa051310.98042058
98Inositol phosphate metabolism_Homo sapiens_hsa005620.97618174
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.96376211
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96015361
101Tryptophan metabolism_Homo sapiens_hsa003800.95459510
102Renin secretion_Homo sapiens_hsa049240.94127946
103Salivary secretion_Homo sapiens_hsa049700.93133890
104Oxytocin signaling pathway_Homo sapiens_hsa049210.92793090
105Prolactin signaling pathway_Homo sapiens_hsa049170.90358382
106Legionellosis_Homo sapiens_hsa051340.89648685
107Oocyte meiosis_Homo sapiens_hsa041140.87953200
108Estrogen signaling pathway_Homo sapiens_hsa049150.87671793
109Axon guidance_Homo sapiens_hsa043600.87151415
110mTOR signaling pathway_Homo sapiens_hsa041500.86768138
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.85422668
112Insulin signaling pathway_Homo sapiens_hsa049100.85330036
113Glioma_Homo sapiens_hsa052140.84970407
114Choline metabolism in cancer_Homo sapiens_hsa052310.84396584
115PPAR signaling pathway_Homo sapiens_hsa033200.84077879
116Glucagon signaling pathway_Homo sapiens_hsa049220.83945295
117Notch signaling pathway_Homo sapiens_hsa043300.83371534
118Thyroid cancer_Homo sapiens_hsa052160.80562960
119Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80400988
120AMPK signaling pathway_Homo sapiens_hsa041520.78958423
121Long-term depression_Homo sapiens_hsa047300.78951492
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77868889
123Renal cell carcinoma_Homo sapiens_hsa052110.73192674
124Prostate cancer_Homo sapiens_hsa052150.73030981
125GnRH signaling pathway_Homo sapiens_hsa049120.70868721
126Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68666800
127Phagosome_Homo sapiens_hsa041450.68096371
128Pertussis_Homo sapiens_hsa051330.67735863
129VEGF signaling pathway_Homo sapiens_hsa043700.65913405
130Salmonella infection_Homo sapiens_hsa051320.65870859
131Cysteine and methionine metabolism_Homo sapiens_hsa002700.65463689
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64517815
133Melanogenesis_Homo sapiens_hsa049160.63956129
134Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61884102
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.61271391
136HIF-1 signaling pathway_Homo sapiens_hsa040660.61107233
137ErbB signaling pathway_Homo sapiens_hsa040120.60525263
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59829936
139Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59723272
140Endometrial cancer_Homo sapiens_hsa052130.59614217
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59424844
142MAPK signaling pathway_Homo sapiens_hsa040100.59393738
143Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59188367
144Fat digestion and absorption_Homo sapiens_hsa049750.58556157
145Insulin resistance_Homo sapiens_hsa049310.58538036
146Small cell lung cancer_Homo sapiens_hsa052220.57729646
147Folate biosynthesis_Homo sapiens_hsa007900.56176962
148Adipocytokine signaling pathway_Homo sapiens_hsa049200.56001581
149cAMP signaling pathway_Homo sapiens_hsa040240.55628832
150Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55567521
151Bladder cancer_Homo sapiens_hsa052190.55088061
152Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54233320
153Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54146860
154Cyanoamino acid metabolism_Homo sapiens_hsa004600.53958456
155Taste transduction_Homo sapiens_hsa047420.53872919
156Fatty acid biosynthesis_Homo sapiens_hsa000610.53821340
157* Endocytosis_Homo sapiens_hsa041440.53387241
158Phospholipase D signaling pathway_Homo sapiens_hsa040720.53123446
159Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52219760
160Glycerolipid metabolism_Homo sapiens_hsa005610.49880373
161Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49847164
162cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49814776
163Arginine and proline metabolism_Homo sapiens_hsa003300.49601500
164Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49532516
165Neurotrophin signaling pathway_Homo sapiens_hsa047220.49089990
166Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48859044
167Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48615145
168Asthma_Homo sapiens_hsa053100.47927917
169Rheumatoid arthritis_Homo sapiens_hsa053230.47436597
170Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47400516
171Calcium signaling pathway_Homo sapiens_hsa040200.46909384
172Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46739340
173beta-Alanine metabolism_Homo sapiens_hsa004100.46010107
174Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45849194
175Glycerophospholipid metabolism_Homo sapiens_hsa005640.45193032
176Vibrio cholerae infection_Homo sapiens_hsa051100.44829888
177Lysosome_Homo sapiens_hsa041420.42524756
178Ras signaling pathway_Homo sapiens_hsa040140.41251634

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