CHN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that contains a phorbol-ester/diacylglycerol (DAG)-type zinc finger, a Rho-GAP domain, and an SH2 domain. The encoded protein translocates from the cytosol to the Golgi apparatus membrane upon binding by diacylglycerol (DAG). Activity of this protein is important in cell proliferation and migration, and expression changes in this gene have been detected in cancers. A mutation in this gene has also been associated with schizophrenia in men. Alternative transcript splicing and the use of alternative promoters results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.21537309
2central nervous system myelination (GO:0022010)7.21537309
3cerebellar granule cell differentiation (GO:0021707)6.52890287
4neuronal action potential propagation (GO:0019227)5.54374338
5response to pheromone (GO:0019236)5.43065705
6locomotory exploration behavior (GO:0035641)5.16850842
7gamma-aminobutyric acid transport (GO:0015812)4.73403212
8myelination (GO:0042552)4.51518775
9L-amino acid import (GO:0043092)4.51417360
10axon ensheathment (GO:0008366)4.47641631
11ensheathment of neurons (GO:0007272)4.47641631
12C4-dicarboxylate transport (GO:0015740)4.46609866
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.28191639
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.27350802
15fatty acid elongation (GO:0030497)4.23974574
16cell differentiation in hindbrain (GO:0021533)4.18342377
17response to methylmercury (GO:0051597)4.15397001
18G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.14360551
19adult walking behavior (GO:0007628)4.09461698
20glutamate receptor signaling pathway (GO:0007215)4.04799394
21protein localization to synapse (GO:0035418)4.01604018
22amino acid import (GO:0043090)3.95829843
23cerebellar Purkinje cell differentiation (GO:0021702)3.93564420
24auditory behavior (GO:0031223)3.89906415
25cellular potassium ion homeostasis (GO:0030007)3.87437879
26synaptic vesicle maturation (GO:0016188)3.85899649
27postsynaptic membrane organization (GO:0001941)3.82033403
28synaptic transmission, glutamatergic (GO:0035249)3.76990494
29behavioral response to nicotine (GO:0035095)3.76613900
30negative regulation of protein localization to cell surface (GO:2000009)3.75539638
31long-chain fatty acid biosynthetic process (GO:0042759)3.72405946
32positive regulation of synapse maturation (GO:0090129)3.70875547
33positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.69675933
34neuron cell-cell adhesion (GO:0007158)3.67453594
35transmission of nerve impulse (GO:0019226)3.65433681
36gamma-aminobutyric acid signaling pathway (GO:0007214)3.61626508
37negative regulation of neurotransmitter transport (GO:0051589)3.58681623
38sodium ion export (GO:0071436)3.52464735
39regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.50810636
40presynaptic membrane organization (GO:0097090)3.50005202
41positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.49111340
42activated T cell proliferation (GO:0050798)3.48985090
43pyrimidine nucleobase catabolic process (GO:0006208)3.45798324
44positive regulation of membrane potential (GO:0045838)3.43886198
45proline transport (GO:0015824)3.40278216
46cellular sodium ion homeostasis (GO:0006883)3.38574843
47regulation of synaptic vesicle exocytosis (GO:2000300)3.37828289
48neuron-neuron synaptic transmission (GO:0007270)3.37730184
49acidic amino acid transport (GO:0015800)3.37458201
50neuromuscular process controlling posture (GO:0050884)3.35648469
51regulation of synapse structural plasticity (GO:0051823)3.34968451
52L-glutamate transport (GO:0015813)3.32734802
53regulation of neuronal synaptic plasticity (GO:0048168)3.31861919
54synaptic vesicle exocytosis (GO:0016079)3.29079805
55nucleobase catabolic process (GO:0046113)3.27628711
56regulation of synapse maturation (GO:0090128)3.26175890
57regulation of glutamate receptor signaling pathway (GO:1900449)3.24791488
58neurotransmitter secretion (GO:0007269)3.24270554
59cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.18637369
60negative regulation of inclusion body assembly (GO:0090084)3.17950746
61potassium ion import (GO:0010107)3.17069440
62regulation of long-term neuronal synaptic plasticity (GO:0048169)3.16996620
63negative regulation of neurotransmitter secretion (GO:0046929)3.16974087
64dendrite morphogenesis (GO:0048813)3.16892858
65vocalization behavior (GO:0071625)3.14441434
66negative regulation of synaptic transmission, GABAergic (GO:0032229)3.14346098
67regulation of short-term neuronal synaptic plasticity (GO:0048172)3.13542810
68long-term memory (GO:0007616)3.11948905
69glutamate secretion (GO:0014047)3.11634310
70regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.11149304
71positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.10280351
72detection of temperature stimulus involved in sensory perception (GO:0050961)3.09996747
73detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.09996747
74exploration behavior (GO:0035640)3.09005722
75regulation of voltage-gated calcium channel activity (GO:1901385)3.08599780
76multicellular organismal movement (GO:0050879)3.06617666
77musculoskeletal movement (GO:0050881)3.06617666
78response to auditory stimulus (GO:0010996)3.06027077
79neuromuscular process controlling balance (GO:0050885)2.97514451
80positive regulation of dendritic spine development (GO:0060999)2.97214129
81potassium ion homeostasis (GO:0055075)2.95627674
82regulation of postsynaptic membrane potential (GO:0060078)2.94915335
83regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.93712850
84regulation of neurotransmitter secretion (GO:0046928)2.93208682
85regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.92973815
86glycine transport (GO:0015816)2.92881875
87glycerophospholipid catabolic process (GO:0046475)2.91248391
88membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.91125753
89positive regulation of dendritic spine morphogenesis (GO:0061003)2.91079625
90presynaptic membrane assembly (GO:0097105)2.90412638
91short-term memory (GO:0007614)2.87519634
92axonal fasciculation (GO:0007413)2.86901584
93neuronal ion channel clustering (GO:0045161)2.86565725
94membrane depolarization (GO:0051899)2.86300556
95neurotransmitter transport (GO:0006836)2.85259746
96neurofilament cytoskeleton organization (GO:0060052)2.84433736
97regulation of synaptic transmission, glutamatergic (GO:0051966)2.84069595
98neuron recognition (GO:0008038)2.82988500
99positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.81271612
100regulation of synaptic vesicle transport (GO:1902803)2.79195831
101creatine metabolic process (GO:0006600)2.79074280
102detection of temperature stimulus (GO:0016048)2.78501819
103neuron remodeling (GO:0016322)2.76167754
104myelin maintenance (GO:0043217)2.74159909
105calcium ion-dependent exocytosis (GO:0017156)2.73602244
106regulation of dendritic spine morphogenesis (GO:0061001)2.72260134
107membrane tubulation (GO:0097320)2.71566312
108dendritic spine morphogenesis (GO:0060997)2.71458488
109regulation of neurotransmitter transport (GO:0051588)2.71248180
110regulation of vesicle fusion (GO:0031338)2.70726777
111cell migration in hindbrain (GO:0021535)2.69234150
112protein localization to cilium (GO:0061512)2.68920563
113establishment of nucleus localization (GO:0040023)2.68646908
114primary amino compound metabolic process (GO:1901160)2.68252527
115serotonin metabolic process (GO:0042428)2.67962840
116sodium ion homeostasis (GO:0055078)2.67554491
117regulation of excitatory postsynaptic membrane potential (GO:0060079)2.66448700
118regulation of calcium ion-dependent exocytosis (GO:0017158)2.66444342
119mating behavior (GO:0007617)2.66289411
120exogenous drug catabolic process (GO:0042738)2.65849229
121peripheral nervous system axon ensheathment (GO:0032292)2.65123735
122myelination in peripheral nervous system (GO:0022011)2.65123735
123synaptic transmission (GO:0007268)2.64450452
124multicellular organismal signaling (GO:0035637)2.63866592
125regulation of neurotransmitter levels (GO:0001505)2.63764409
126drug catabolic process (GO:0042737)2.61604595
127response to histamine (GO:0034776)2.61280322
128neuromuscular synaptic transmission (GO:0007274)2.60949312
129membrane hyperpolarization (GO:0060081)2.60392573
130mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.60297446
131oligodendrocyte differentiation (GO:0048709)2.59496035
132layer formation in cerebral cortex (GO:0021819)2.58581554
133neurotransmitter uptake (GO:0001504)2.58091608
134adult locomotory behavior (GO:0008344)2.56293724
135acrosome reaction (GO:0007340)2.53932624
136membrane depolarization during action potential (GO:0086010)2.53176026
137substantia nigra development (GO:0021762)2.52398910
138mechanosensory behavior (GO:0007638)2.50584428
139photoreceptor cell differentiation (GO:0046530)2.49849961
140eye photoreceptor cell differentiation (GO:0001754)2.49849961
141neurotransmitter-gated ion channel clustering (GO:0072578)2.48329877
142synapse assembly (GO:0007416)2.47757167
143negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.47075273
144long-term synaptic potentiation (GO:0060291)2.46244529
145regulation of beta-amyloid formation (GO:1902003)2.46206791
146establishment of mitochondrion localization (GO:0051654)2.45030656
147response to redox state (GO:0051775)2.45000917

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.86454930
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.86150136
3GBX2_23144817_ChIP-Seq_PC3_Human2.53657818
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.53456467
5DROSHA_22980978_ChIP-Seq_HELA_Human2.53340674
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.38315805
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.38315805
8MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34637055
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.33008081
10EZH2_27294783_Chip-Seq_ESCs_Mouse2.22032223
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.19888362
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.12943444
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.08448938
14REST_21632747_ChIP-Seq_MESCs_Mouse2.06452123
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.04948708
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.03066502
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.02409021
18EED_16625203_ChIP-ChIP_MESCs_Mouse1.97914428
19IKZF1_21737484_ChIP-ChIP_HCT116_Human1.92995989
20RNF2_27304074_Chip-Seq_ESCs_Mouse1.92611933
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.84957499
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.83524642
23* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.77003543
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68999634
25IGF1R_20145208_ChIP-Seq_DFB_Human1.67462985
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67295820
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67134661
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.63514027
29TAF15_26573619_Chip-Seq_HEK293_Human1.59184910
30RARB_27405468_Chip-Seq_BRAIN_Mouse1.57584343
31VDR_22108803_ChIP-Seq_LS180_Human1.53041642
32AR_21572438_ChIP-Seq_LNCaP_Human1.50975854
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.50677682
34RNF2_27304074_Chip-Seq_NSC_Mouse1.48358232
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43183738
36OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42560656
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40474408
38RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.39755908
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39377198
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38041611
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37717367
42* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36704015
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.36138939
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35447282
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33550969
46* SMAD4_21799915_ChIP-Seq_A2780_Human1.33490849
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30115992
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30101102
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.27144485
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26010143
51ZNF274_21170338_ChIP-Seq_K562_Hela1.25396379
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23439626
53* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20091835
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19361675
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19227634
56* STAT3_23295773_ChIP-Seq_U87_Human1.15497763
57TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14723628
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.14471637
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.14453957
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12899877
61ER_23166858_ChIP-Seq_MCF-7_Human1.11895065
62P300_19829295_ChIP-Seq_ESCs_Human1.11801101
63* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09018180
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08885949
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08885949
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08458517
67BCAT_22108803_ChIP-Seq_LS180_Human1.06903642
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05654561
69BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05406681
70CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03638620
71TCF4_23295773_ChIP-Seq_U87_Human1.03508017
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03386183
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02808836
74ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02353840
75* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02218225
76RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01618466
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00645800
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.00528599
79* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99933657
80PRDM14_20953172_ChIP-Seq_ESCs_Human0.99664009
81* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98635117
82NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98597971
83TAL1_26923725_Chip-Seq_HPCs_Mouse0.97101193
84* SMAD4_21741376_ChIP-Seq_EPCs_Human0.96723332
85KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96608671
86CMYC_18555785_Chip-Seq_ESCs_Mouse0.96175212
87* TCF4_22108803_ChIP-Seq_LS180_Human0.95728162
88FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95617083
89RING1B_27294783_Chip-Seq_ESCs_Mouse0.95453575
90* AR_19668381_ChIP-Seq_PC3_Human0.94931888
91* SOX2_21211035_ChIP-Seq_LN229_Gbm0.94783259
92AR_25329375_ChIP-Seq_VCAP_Human0.94778112
93ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94611001
94RUNX2_22187159_ChIP-Seq_PCA_Human0.93968627
95CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93627962
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93577935
97FUS_26573619_Chip-Seq_HEK293_Human0.92897478
98* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92358009
99* SMAD3_21741376_ChIP-Seq_ESCs_Human0.91150265
100NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90761719
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90479108
102CBP_20019798_ChIP-Seq_JUKART_Human0.90479108
103EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89917060
104* ARNT_22903824_ChIP-Seq_MCF-7_Human0.89207525
105GATA1_26923725_Chip-Seq_HPCs_Mouse0.88408835
106* SMAD4_21741376_ChIP-Seq_HESCs_Human0.86365964
107DNAJC2_21179169_ChIP-ChIP_NT2_Human0.86248780
108HTT_18923047_ChIP-ChIP_STHdh_Human0.85689742
109CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85673488
110LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85439084
111STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.85435762
112P300_18555785_Chip-Seq_ESCs_Mouse0.84817332
113RING1B_27294783_Chip-Seq_NPCs_Mouse0.84704118
114P53_22127205_ChIP-Seq_FIBROBLAST_Human0.84678258
115KDM2B_26808549_Chip-Seq_REH_Human0.84568784
116PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84015025
117PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83974402
118TBL1_22424771_ChIP-Seq_293T_Human0.83781233
119SUZ12_18555785_Chip-Seq_ESCs_Mouse0.83638192
120GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83254277
121P53_22387025_ChIP-Seq_ESCs_Mouse0.82882156
122* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.82879811
123TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.82263931
124E2F1_18555785_Chip-Seq_ESCs_Mouse0.82204883

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009046_muscle_twitch4.57203659
2MP0004859_abnormal_synaptic_plasticity4.05523782
3MP0000920_abnormal_myelination3.86656143
4MP0003635_abnormal_synaptic_transmissio3.24535543
5MP0002272_abnormal_nervous_system3.24298024
6MP0002064_seizures3.10699716
7MP0003880_abnormal_central_pattern3.07814081
8MP0008569_lethality_at_weaning3.00821512
9MP0004270_analgesia2.98709922
10MP0002822_catalepsy2.80907637
11MP0009745_abnormal_behavioral_response2.79558650
12MP0005410_abnormal_fertilization2.72920699
13MP0004742_abnormal_vestibular_system2.71106007
14MP0003329_amyloid_beta_deposits2.69077242
15MP0003690_abnormal_glial_cell2.66784590
16MP0003787_abnormal_imprinting2.60673544
17MP0001486_abnormal_startle_reflex2.54321255
18MP0004142_abnormal_muscle_tone2.40201763
19MP0005423_abnormal_somatic_nervous2.40058439
20MP0002734_abnormal_mechanical_nocicepti2.36280868
21MP0004885_abnormal_endolymph2.34558857
22MP0002067_abnormal_sensory_capabilities2.27126551
23MP0001440_abnormal_grooming_behavior2.26851962
24MP0002063_abnormal_learning/memory/cond2.26435159
25MP0004147_increased_porphyrin_level2.26283614
26MP0002572_abnormal_emotion/affect_behav2.24949968
27MP0001968_abnormal_touch/_nociception2.07691586
28MP0003632_abnormal_nervous_system2.04161352
29MP0005085_abnormal_gallbladder_physiolo2.02577873
30MP0006276_abnormal_autonomic_nervous1.98017274
31MP0000778_abnormal_nervous_system1.97949734
32MP0005365_abnormal_bile_salt1.92285242
33MP0002736_abnormal_nociception_after1.87091660
34MP0003634_abnormal_glial_cell1.69703530
35* MP0002184_abnormal_innervation1.68225316
36MP0003122_maternal_imprinting1.67623974
37MP0002735_abnormal_chemical_nociception1.65391446
38MP0003631_nervous_system_phenotype1.60314446
39MP0001970_abnormal_pain_threshold1.59860127
40MP0000604_amyloidosis1.59211775
41* MP0000955_abnormal_spinal_cord1.55361441
42* MP0002066_abnormal_motor_capabilities/c1.54389346
43MP0004043_abnormal_pH_regulation1.53567029
44MP0002638_abnormal_pupillary_reflex1.53406050
45MP0002229_neurodegeneration1.53340328
46MP0003633_abnormal_nervous_system1.52911989
47MP0005386_behavior/neurological_phenoty1.52629054
48MP0004924_abnormal_behavior1.52629054
49MP0001501_abnormal_sleep_pattern1.51395074
50MP0001666_abnormal_nutrient_absorption1.49467374
51MP0002557_abnormal_social/conspecific_i1.48624410
52MP0001529_abnormal_vocalization1.48221207
53MP0005171_absent_coat_pigmentation1.45180996
54MP0002733_abnormal_thermal_nociception1.44828000
55MP0009379_abnormal_foot_pigmentation1.41238278
56MP0001986_abnormal_taste_sensitivity1.40750262
57* MP0002882_abnormal_neuron_morphology1.37448727
58MP0001905_abnormal_dopamine_level1.30771901
59MP0001188_hyperpigmentation1.28757413
60MP0008877_abnormal_DNA_methylation1.27230032
61MP0005083_abnormal_biliary_tract1.26944153
62MP0001299_abnormal_eye_distance/1.25541987
63MP0001485_abnormal_pinna_reflex1.24884852
64MP0003123_paternal_imprinting1.23154758
65MP0001502_abnormal_circadian_rhythm1.21919953
66MP0005551_abnormal_eye_electrophysiolog1.16454628
67MP0005394_taste/olfaction_phenotype1.14993043
68MP0005499_abnormal_olfactory_system1.14993043
69MP0003121_genomic_imprinting1.14914669
70MP0002876_abnormal_thyroid_physiology1.13679815
71MP0002909_abnormal_adrenal_gland1.12992026
72MP0002152_abnormal_brain_morphology1.07179163
73MP0001963_abnormal_hearing_physiology1.06326736
74MP0003136_yellow_coat_color1.05297977
75MP0002139_abnormal_hepatobiliary_system1.02275632
76MP0005535_abnormal_body_temperature1.01671941
77MP0005360_urolithiasis1.00225155
78MP0003172_abnormal_lysosome_physiology0.99168824
79MP0002102_abnormal_ear_morphology0.98846106
80MP0005167_abnormal_blood-brain_barrier0.98121151
81MP0003950_abnormal_plasma_membrane0.97480573
82MP0004811_abnormal_neuron_physiology0.96729394
83MP0004019_abnormal_vitamin_homeostasis0.94787686
84MP0008872_abnormal_physiological_respon0.92746871
85MP0010329_abnormal_lipoprotein_level0.92233387
86MP0003252_abnormal_bile_duct0.90090580
87MP0001984_abnormal_olfaction0.89582654
88MP0003698_abnormal_male_reproductive0.89109218
89* MP0002752_abnormal_somatic_nervous0.88099183
90MP0003868_abnormal_feces_composition0.87328073
91MP0000462_abnormal_digestive_system0.86649320
92MP0006292_abnormal_olfactory_placode0.84642117
93MP0005448_abnormal_energy_balance0.82296381
94MP0006082_CNS_inflammation0.80895997
95MP0008875_abnormal_xenobiotic_pharmacok0.80893825
96MP0001177_atelectasis0.77473938
97MP0005623_abnormal_meninges_morphology0.77013344
98MP0008874_decreased_physiological_sensi0.75799345
99MP0003183_abnormal_peptide_metabolism0.75439494
100MP0003195_calcinosis0.75426660
101MP0002069_abnormal_eating/drinking_beha0.75283925
102MP0000569_abnormal_digit_pigmentation0.74875348
103MP0005409_darkened_coat_color0.74828716
104MP0003137_abnormal_impulse_conducting0.74154968
105MP0000631_abnormal_neuroendocrine_gland0.72823278
106MP0002090_abnormal_vision0.72554534
107MP0004134_abnormal_chest_morphology0.71445723
108MP0000579_abnormal_nail_morphology0.71265582
109MP0000566_synostosis0.68780260
110MP0003938_abnormal_ear_development0.67590927
111MP0001664_abnormal_digestion0.67301553
112MP0010386_abnormal_urinary_bladder0.66343800
113MP0000747_muscle_weakness0.66341302
114MP0005646_abnormal_pituitary_gland0.65544847
115MP0005253_abnormal_eye_physiology0.65262927
116MP0008789_abnormal_olfactory_epithelium0.64691298
117MP0002653_abnormal_ependyma_morphology0.63387318
118MP0000639_abnormal_adrenal_gland0.62822982
119MP0005584_abnormal_enzyme/coenzyme_acti0.62617891
120MP0003283_abnormal_digestive_organ0.61866963
121MP0001851_eye_inflammation0.61195758
122* MP0004145_abnormal_muscle_electrophysio0.59662944
123MP0003879_abnormal_hair_cell0.59601890
124MP0005195_abnormal_posterior_eye0.58441134
125MP0005645_abnormal_hypothalamus_physiol0.58424590
126MP0000467_abnormal_esophagus_morphology0.57281169
127MP0000026_abnormal_inner_ear0.55688608
128MP0005332_abnormal_amino_acid0.54065851
129MP0003656_abnormal_erythrocyte_physiolo0.53720047
130MP0010769_abnormal_survival0.52857633
131MP0002118_abnormal_lipid_homeostasis0.52407624
132MP0002161_abnormal_fertility/fecundity0.51293136
133MP0009840_abnormal_foam_cell0.50420614
134MP0001348_abnormal_lacrimal_gland0.49953143
135MP0010770_preweaning_lethality0.49881415

Predicted human phenotypes

RankGene SetZ-score
1Action tremor (HP:0002345)6.27092694
2Scanning speech (HP:0002168)5.24722039
3Intention tremor (HP:0002080)5.22079360
4Progressive cerebellar ataxia (HP:0002073)5.19187971
5Neurofibrillary tangles (HP:0002185)4.97286269
6Gaze-evoked nystagmus (HP:0000640)4.85539262
7Focal motor seizures (HP:0011153)4.72578448
8Myokymia (HP:0002411)4.59763072
9Dysmetria (HP:0001310)4.59009836
10Abnormality of the corticospinal tract (HP:0002492)4.58488908
11Limb dystonia (HP:0002451)4.28935106
12Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.20445394
13Degeneration of the lateral corticospinal tracts (HP:0002314)4.20445394
14Dysdiadochokinesis (HP:0002075)4.11573485
15Focal seizures (HP:0007359)3.80099394
16Atonic seizures (HP:0010819)3.79790501
17Supranuclear gaze palsy (HP:0000605)3.72038244
18Visual hallucinations (HP:0002367)3.69102558
19Cerebral inclusion bodies (HP:0100314)3.56403020
20Spastic gait (HP:0002064)3.54611915
21Broad-based gait (HP:0002136)3.46005514
22Peripheral hypomyelination (HP:0007182)3.27435090
23Abnormality of saccadic eye movements (HP:0000570)3.11255951
24Hemiparesis (HP:0001269)3.05383118
25Diplopia (HP:0000651)3.03907258
26Abnormality of binocular vision (HP:0011514)3.03907258
27Dysmetric saccades (HP:0000641)3.01694160
28Hemiplegia (HP:0002301)3.01365485
29Spastic tetraparesis (HP:0001285)2.98567454
30Postural tremor (HP:0002174)2.98386795
31Impaired smooth pursuit (HP:0007772)2.97133920
32Epileptic encephalopathy (HP:0200134)2.95813356
33Sensory axonal neuropathy (HP:0003390)2.95256787
34Truncal ataxia (HP:0002078)2.92485409
35Abnormality of ocular smooth pursuit (HP:0000617)2.87774375
36Polyphagia (HP:0002591)2.84951860
37Morphological abnormality of the pyramidal tract (HP:0002062)2.82535952
38Gait imbalance (HP:0002141)2.82342852
39Tetraplegia (HP:0002445)2.80582038
40Cerebral hypomyelination (HP:0006808)2.77338986
41Ankle clonus (HP:0011448)2.72614581
42Onion bulb formation (HP:0003383)2.63764987
43Split foot (HP:0001839)2.60959348
44Febrile seizures (HP:0002373)2.54161230
45Genetic anticipation (HP:0003743)2.51256441
46Neuronal loss in central nervous system (HP:0002529)2.51120810
47Urinary bladder sphincter dysfunction (HP:0002839)2.47951941
48Drooling (HP:0002307)2.47768512
49Impaired vibration sensation in the lower limbs (HP:0002166)2.47061634
50Absence seizures (HP:0002121)2.46965343
51Medial flaring of the eyebrow (HP:0010747)2.44672838
52Abnormality of glutamine family amino acid metabolism (HP:0010902)2.43020940
53Torticollis (HP:0000473)2.42401006
54Pheochromocytoma (HP:0002666)2.39611475
55Status epilepticus (HP:0002133)2.39005002
56Dialeptic seizures (HP:0011146)2.37716932
57Epileptiform EEG discharges (HP:0011182)2.36835902
58Oligodactyly (hands) (HP:0001180)2.33835848
59Alacrima (HP:0000522)2.32629616
60Gait ataxia (HP:0002066)2.31306990
61Excessive salivation (HP:0003781)2.30935975
62Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.29929126
63Confusion (HP:0001289)2.26297150
64Abnormal ciliary motility (HP:0012262)2.25393011
65Limb ataxia (HP:0002070)2.24844890
66Clonus (HP:0002169)2.24608729
67Congenital primary aphakia (HP:0007707)2.23063735
68Abnormal respiratory motile cilium morphology (HP:0005938)2.22298202
69Abnormal respiratory epithelium morphology (HP:0012253)2.22298202
70Postural instability (HP:0002172)2.19984805
71Focal dystonia (HP:0004373)2.19962166
72Absent/shortened dynein arms (HP:0200106)2.19439102
73Dynein arm defect of respiratory motile cilia (HP:0012255)2.19439102
74Poor eye contact (HP:0000817)2.16989532
75EEG with generalized epileptiform discharges (HP:0011198)2.16936341
76Hypsarrhythmia (HP:0002521)2.16884733
77Termporal pattern (HP:0011008)2.16476725
78Insidious onset (HP:0003587)2.16476725
79Amyotrophic lateral sclerosis (HP:0007354)2.15323411
80Generalized tonic-clonic seizures (HP:0002069)2.14871602
81Anxiety (HP:0000739)2.13633454
82Abnormal auditory evoked potentials (HP:0006958)2.13493484
83Ventricular fibrillation (HP:0001663)2.11968335
84Neuroendocrine neoplasm (HP:0100634)2.10152404
85Nephrogenic diabetes insipidus (HP:0009806)2.09837002
86Mutism (HP:0002300)2.09294892
87Cerebral hemorrhage (HP:0001342)2.08899168
88Papilledema (HP:0001085)2.08609843
89Abnormal eating behavior (HP:0100738)2.07741870
90Hyperventilation (HP:0002883)2.07680217
91Sleep apnea (HP:0010535)2.06469305
92Anteriorly placed anus (HP:0001545)2.04623429
93Spastic tetraplegia (HP:0002510)2.03908874
94Slow saccadic eye movements (HP:0000514)2.03294674
95Type II lissencephaly (HP:0007260)2.03086374
96Clumsiness (HP:0002312)2.02829991
97CNS hypomyelination (HP:0003429)2.01539917
98Depression (HP:0000716)2.01412254
99Slow progression (HP:0003677)2.00981818
100Retinal dysplasia (HP:0007973)2.00536182
101Generalized myoclonic seizures (HP:0002123)2.00095757
102Abnormal social behavior (HP:0012433)1.98904830
103Impaired social interactions (HP:0000735)1.98904830
104Specific learning disability (HP:0001328)1.98781868
105Psychosis (HP:0000709)1.97326480
106Chronic hepatic failure (HP:0100626)1.96285427
107Premature skin wrinkling (HP:0100678)1.95376489
108Genital tract atresia (HP:0001827)1.95033895
109Megalencephaly (HP:0001355)1.94959469
110Vaginal atresia (HP:0000148)1.94923301
111Facial shape deformation (HP:0011334)1.89947314
112Potter facies (HP:0002009)1.89947314
113Choreoathetosis (HP:0001266)1.89728672
114Urinary urgency (HP:0000012)1.89486586
115Lower limb muscle weakness (HP:0007340)1.89228601
116Horizontal nystagmus (HP:0000666)1.88398425
117Abnormality of urine glucose concentration (HP:0011016)1.88383576
118Glycosuria (HP:0003076)1.88383576
119Amblyopia (HP:0000646)1.86411063
120Agitation (HP:0000713)1.85798731
121Syncope (HP:0001279)1.84900808
122Decreased lacrimation (HP:0000633)1.84443716
123Prolonged QT interval (HP:0001657)1.83637115
124Abnormality of the lower motor neuron (HP:0002366)1.83224526
125Dysarthria (HP:0001260)1.82985385
126Inability to walk (HP:0002540)1.82748480
127Hepatoblastoma (HP:0002884)1.82318801
128Decreased circulating renin level (HP:0003351)1.81816142
129Blue irides (HP:0000635)1.81692899
130Absent speech (HP:0001344)1.79992415
131Choroideremia (HP:0001139)1.79147794
132Increased circulating renin level (HP:0000848)1.79038634
133Metabolic alkalosis (HP:0200114)1.77808095
134Hypobetalipoproteinemia (HP:0003563)1.77541681
135Craniofacial dystonia (HP:0012179)1.77357748
136Spastic paraplegia (HP:0001258)1.77081837
137Molar tooth sign on MRI (HP:0002419)1.76949406
138Abnormality of midbrain morphology (HP:0002418)1.76949406
139Humeroradial synostosis (HP:0003041)1.76869776
140Synostosis involving the elbow (HP:0003938)1.76869776
141Nephronophthisis (HP:0000090)1.76869169
142True hermaphroditism (HP:0010459)1.76003186
143Hyperglycinuria (HP:0003108)1.76002311
144Cerebellar atrophy (HP:0001272)1.75789425
145Poor speech (HP:0002465)1.75486317
146Abnormal respiratory motile cilium physiology (HP:0012261)1.73249858
147Abnormality of aromatic amino acid family metabolism (HP:0004338)1.73221989
148Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.72665196
149Hydroxyprolinuria (HP:0003080)1.72110749
150Abnormality of proline metabolism (HP:0010907)1.72110749

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.00357251
2OXSR13.46881698
3TYRO32.95625976
4EPHB12.91810982
5CDK192.83385809
6WNK12.79574586
7PRPF4B2.52987935
8CAMKK22.50695110
9PKN12.16114292
10ICK2.01913458
11PNCK1.94295018
12TNIK1.90099246
13BCR1.83974313
14MAPKAPK51.81693575
15NEK61.80715596
16CASK1.80109880
17NTRK21.68232771
18PAK61.67145724
19FGFR21.63521293
20FRK1.63096014
21UHMK11.60872075
22FES1.60378268
23NTRK31.60061746
24MARK11.56911149
25SGK4941.46748942
26SGK2231.46748942
27NTRK11.42676320
28WNK41.41521913
29SIK21.39479135
30DYRK21.38247956
31MAP3K41.36307204
32SGK21.35713573
33ROCK21.35428034
34MINK11.33691060
35CAMKK11.32922638
36CAMK2B1.31549649
37MAP3K91.25768273
38CAMK2G1.25671202
39LIMK11.25506397
40RIPK11.21792447
41IRAK21.20397665
42ACVR1B1.19187280
43DAPK21.18853655
44CAMK1G1.15374905
45TESK21.12360356
46CAMK2D1.10907564
47ADRBK21.04709584
48WNK31.04694902
49CDK51.02949373
50PDPK11.01962855
51MAP2K70.97935594
52DYRK1B0.97922291
53MAP2K40.94681616
54MAPK130.94559946
55PDK10.94342843
56CDK150.92732890
57PRKCH0.92339152
58CDK180.90623715
59CAMK2A0.89502095
60PRKCG0.88057078
61CSNK1G20.87990640
62CSNK1G30.87042020
63CSNK1A1L0.86273438
64BMPR1B0.86168681
65CDK140.85108202
66PDK20.83382529
67EPHA40.83140780
68PRKCZ0.82895612
69PLK20.82673813
70CDK11A0.81934286
71MARK20.77795911
72PBK0.77659706
73PINK10.76103317
74STK380.75252559
75PIK3CA0.73458199
76TAOK30.73040011
77STK110.72026640
78PHKG20.70525920
79PHKG10.70525920
80MAP3K130.69023775
81PRKCQ0.68465370
82RIPK40.67914369
83PTK20.66981936
84PRKG10.66003796
85CAMK10.65674412
86* FYN0.63819898
87MET0.63715037
88SGK30.63408579
89GRK10.58328337
90KSR20.57395701
91EPHA30.56727504
92CSNK1G10.56205488
93RET0.53858597
94GRK50.52604311
95PRKCA0.52565468
96PDK40.51310963
97PDK30.51310963
98INSRR0.51166453
99CSK0.50550779
100PTK60.50017659
101ITK0.49924238
102FGR0.48840501
103PDGFRB0.48831152
104MAP4K20.48580531
105PRKD30.48526389
106KSR10.48225841
107DAPK10.47613736
108PRKACG0.46010953
109ERBB20.45451314
110INSR0.44527371
111PAK30.44105842
112MAPK150.43756879
113DYRK1A0.43712145
114PRKACB0.43704879
115CAMK40.43636893
116PRKD10.42587563
117TAOK10.40324427
118RPS6KA30.40311305
119SGK10.40235651
120CSNK1A10.40232019
121* SRC0.39659841
122ARAF0.39452038
123PRKAA10.39440633
124PRKCE0.39366275
125PRKACA0.39245630
126CSNK1E0.36677169
127PRKCB0.33381716
128BMPR20.30487735

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.35167585
2Glutamatergic synapse_Homo sapiens_hsa047242.78531944
3Nitrogen metabolism_Homo sapiens_hsa009102.51640233
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.45316036
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.34096973
6Long-term depression_Homo sapiens_hsa047302.28112939
7GABAergic synapse_Homo sapiens_hsa047272.27522485
8Synaptic vesicle cycle_Homo sapiens_hsa047212.15660859
9Fatty acid elongation_Homo sapiens_hsa000622.02113120
10Long-term potentiation_Homo sapiens_hsa047202.00783650
11Circadian entrainment_Homo sapiens_hsa047131.95377567
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.90657465
13Morphine addiction_Homo sapiens_hsa050321.89693267
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.85074659
15Steroid biosynthesis_Homo sapiens_hsa001001.84161730
16Salivary secretion_Homo sapiens_hsa049701.83951199
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.79534999
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.71120502
19Fat digestion and absorption_Homo sapiens_hsa049751.69450340
20Caffeine metabolism_Homo sapiens_hsa002321.69404887
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.65904152
22Ether lipid metabolism_Homo sapiens_hsa005651.63545318
23Taste transduction_Homo sapiens_hsa047421.63409567
24Amphetamine addiction_Homo sapiens_hsa050311.44540316
25Phototransduction_Homo sapiens_hsa047441.44435434
26Gastric acid secretion_Homo sapiens_hsa049711.43820655
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.38148612
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35686186
29Vitamin B6 metabolism_Homo sapiens_hsa007501.33213569
30Chemical carcinogenesis_Homo sapiens_hsa052041.30524757
31Cholinergic synapse_Homo sapiens_hsa047251.29799297
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27363582
33Dopaminergic synapse_Homo sapiens_hsa047281.26077986
34Tryptophan metabolism_Homo sapiens_hsa003801.25914020
35Retinol metabolism_Homo sapiens_hsa008301.23145598
36Butanoate metabolism_Homo sapiens_hsa006501.19631405
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18125213
38Serotonergic synapse_Homo sapiens_hsa047261.16423961
39Axon guidance_Homo sapiens_hsa043601.15933056
40Bile secretion_Homo sapiens_hsa049761.15029709
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.14805221
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.13272083
43Pancreatic secretion_Homo sapiens_hsa049721.11426596
44Aldosterone synthesis and secretion_Homo sapiens_hsa049251.11419425
45Vitamin digestion and absorption_Homo sapiens_hsa049771.07244139
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.03911508
47Collecting duct acid secretion_Homo sapiens_hsa049661.02124532
48Arginine biosynthesis_Homo sapiens_hsa002200.99108246
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98822937
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.97880124
51Sulfur metabolism_Homo sapiens_hsa009200.96161125
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95848525
53Insulin secretion_Homo sapiens_hsa049110.95742267
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95125084
55Oxidative phosphorylation_Homo sapiens_hsa001900.94956289
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.94196180
57Type II diabetes mellitus_Homo sapiens_hsa049300.93820704
58cAMP signaling pathway_Homo sapiens_hsa040240.92330393
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.91283550
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.90468204
61Calcium signaling pathway_Homo sapiens_hsa040200.88710947
62Oxytocin signaling pathway_Homo sapiens_hsa049210.87917212
63Renin secretion_Homo sapiens_hsa049240.86807415
64Thyroid hormone synthesis_Homo sapiens_hsa049180.86076378
65Cocaine addiction_Homo sapiens_hsa050300.83878668
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83453168
67Renin-angiotensin system_Homo sapiens_hsa046140.82404385
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81378284
69Phenylalanine metabolism_Homo sapiens_hsa003600.80935557
70PPAR signaling pathway_Homo sapiens_hsa033200.80533824
71Olfactory transduction_Homo sapiens_hsa047400.80239712
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79919588
73Histidine metabolism_Homo sapiens_hsa003400.78393555
74Starch and sucrose metabolism_Homo sapiens_hsa005000.77932569
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77736898
76Sphingolipid metabolism_Homo sapiens_hsa006000.77213631
77Gap junction_Homo sapiens_hsa045400.76864688
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76479927
79beta-Alanine metabolism_Homo sapiens_hsa004100.76339772
80Fatty acid biosynthesis_Homo sapiens_hsa000610.75506180
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.75416311
82Regulation of autophagy_Homo sapiens_hsa041400.75376754
83Arachidonic acid metabolism_Homo sapiens_hsa005900.71676969
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.71590973
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.69377341
86Inositol phosphate metabolism_Homo sapiens_hsa005620.69045665
87Choline metabolism in cancer_Homo sapiens_hsa052310.68445000
88Mineral absorption_Homo sapiens_hsa049780.68321018
89Cardiac muscle contraction_Homo sapiens_hsa042600.67739537
90Estrogen signaling pathway_Homo sapiens_hsa049150.66419573
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66272153
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64570815
93Tyrosine metabolism_Homo sapiens_hsa003500.64027739
94Protein digestion and absorption_Homo sapiens_hsa049740.63246117
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62520673
96Fatty acid degradation_Homo sapiens_hsa000710.62371824
97Parkinsons disease_Homo sapiens_hsa050120.61639791
98Fatty acid metabolism_Homo sapiens_hsa012120.61615500
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58688709
100GnRH signaling pathway_Homo sapiens_hsa049120.55997048
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55618720
102Arginine and proline metabolism_Homo sapiens_hsa003300.53675185
103Complement and coagulation cascades_Homo sapiens_hsa046100.53060013
104Endocytosis_Homo sapiens_hsa041440.52364701
105Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51224022
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49783343
107Renal cell carcinoma_Homo sapiens_hsa052110.47706862
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47495058
109ErbB signaling pathway_Homo sapiens_hsa040120.47110045
110Propanoate metabolism_Homo sapiens_hsa006400.46976250
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.46957363
112Dorso-ventral axis formation_Homo sapiens_hsa043200.45343197
113ABC transporters_Homo sapiens_hsa020100.45091920
114Prion diseases_Homo sapiens_hsa050200.44825283
115Linoleic acid metabolism_Homo sapiens_hsa005910.44458208
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44426591
117Glycerolipid metabolism_Homo sapiens_hsa005610.43616654
118Steroid hormone biosynthesis_Homo sapiens_hsa001400.43027369
119Vibrio cholerae infection_Homo sapiens_hsa051100.41789770
120Asthma_Homo sapiens_hsa053100.41318093
121Alzheimers disease_Homo sapiens_hsa050100.39719053
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37577270
123Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37446198
124Peroxisome_Homo sapiens_hsa041460.37041168
125Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36885276
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35774668
127Melanogenesis_Homo sapiens_hsa049160.35116548
128Ovarian steroidogenesis_Homo sapiens_hsa049130.34715175
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34322605

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