CHP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a phosphoprotein that binds to the Na+/H+ exchanger NHE1. This protein serves as an essential cofactor which supports the physiological activity of NHE family members and may play a role in the mitogenic regulation of NHE1. The protein shares similarity with calcineurin B and calmodulin and it is also known to be an endogenous inhibitor of calcineurin activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)5.22106003
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.22106003
3L-phenylalanine metabolic process (GO:0006558)5.00016219
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.00016219
5alpha-linolenic acid metabolic process (GO:0036109)4.99057666
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.84528473
7sulfur amino acid catabolic process (GO:0000098)4.73866569
8aromatic amino acid family catabolic process (GO:0009074)4.48574610
9proteasome assembly (GO:0043248)4.38985815
10complement activation, alternative pathway (GO:0006957)4.34735086
11cysteine metabolic process (GO:0006534)4.34085555
12regulation of triglyceride catabolic process (GO:0010896)4.30172968
13fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.23128925
14urea cycle (GO:0000050)4.07641505
15urea metabolic process (GO:0019627)4.07641505
16bile acid biosynthetic process (GO:0006699)4.06831909
17water-soluble vitamin biosynthetic process (GO:0042364)4.04489750
18low-density lipoprotein particle clearance (GO:0034383)4.03180220
19plasma lipoprotein particle clearance (GO:0034381)3.95973672
20respiratory chain complex IV assembly (GO:0008535)3.95395162
21valine metabolic process (GO:0006573)3.94705059
22high-density lipoprotein particle remodeling (GO:0034375)3.92895677
23lysine catabolic process (GO:0006554)3.89649815
24lysine metabolic process (GO:0006553)3.89649815
25keratinocyte development (GO:0003334)3.87984460
26positive regulation of lipid catabolic process (GO:0050996)3.86348141
27positive regulation of fatty acid beta-oxidation (GO:0032000)3.86187569
28peptidyl-glutamic acid carboxylation (GO:0017187)3.84500529
29protein carboxylation (GO:0018214)3.84500529
30kynurenine metabolic process (GO:0070189)3.83323457
31indolalkylamine catabolic process (GO:0046218)3.80682014
32tryptophan catabolic process (GO:0006569)3.80682014
33indole-containing compound catabolic process (GO:0042436)3.80682014
34regulation of protein activation cascade (GO:2000257)3.79173236
35lactate metabolic process (GO:0006089)3.78069089
36platelet dense granule organization (GO:0060155)3.75935107
37negative regulation of fibrinolysis (GO:0051918)3.74929269
38nitrogen cycle metabolic process (GO:0071941)3.74221381
39regulation of sequestering of triglyceride (GO:0010889)3.72351667
40glyoxylate metabolic process (GO:0046487)3.71281641
41acylglycerol homeostasis (GO:0055090)3.70631207
42triglyceride homeostasis (GO:0070328)3.70631207
43regulation of complement activation (GO:0030449)3.63359388
44amino-acid betaine metabolic process (GO:0006577)3.62595723
45tryptophan metabolic process (GO:0006568)3.62501612
46reverse cholesterol transport (GO:0043691)3.60601061
47homocysteine metabolic process (GO:0050667)3.60400497
48bile acid metabolic process (GO:0008206)3.59923651
49fatty acid beta-oxidation (GO:0006635)3.58690850
50regulation of glucokinase activity (GO:0033131)3.55051240
51regulation of hexokinase activity (GO:1903299)3.55051240
52macromolecular complex remodeling (GO:0034367)3.54793546
53plasma lipoprotein particle remodeling (GO:0034369)3.54793546
54protein-lipid complex remodeling (GO:0034368)3.54793546
55acetyl-CoA metabolic process (GO:0006084)3.54356277
56fatty acid oxidation (GO:0019395)3.54009687
57cellular ketone body metabolic process (GO:0046950)3.53507144
58positive regulation of fatty acid oxidation (GO:0046321)3.49846759
59lipid oxidation (GO:0034440)3.49043806
60fatty acid catabolic process (GO:0009062)3.44489932
61triglyceride catabolic process (GO:0019433)3.43767670
62phospholipid efflux (GO:0033700)3.43691783
63cullin deneddylation (GO:0010388)3.42195515
64tyrosine metabolic process (GO:0006570)3.41917948
65xenobiotic catabolic process (GO:0042178)3.41166948
66cytochrome complex assembly (GO:0017004)3.40902853
67regulation of fibrinolysis (GO:0051917)3.40283310
68acylglycerol catabolic process (GO:0046464)3.39867118
69neutral lipid catabolic process (GO:0046461)3.39867118
702-oxoglutarate metabolic process (GO:0006103)3.39310854
71regulation of cholesterol esterification (GO:0010872)3.35521547
72DNA deamination (GO:0045006)3.35341362
73coenzyme catabolic process (GO:0009109)3.32884512
74regulation of fatty acid beta-oxidation (GO:0031998)3.31645664
75response to pheromone (GO:0019236)3.30144239
76serine family amino acid catabolic process (GO:0009071)3.30035282
77monocarboxylic acid catabolic process (GO:0072329)3.28415698
78regulation of cellular amino acid metabolic process (GO:0006521)3.27508088
79positive regulation of protein autophosphorylation (GO:0031954)3.25351500
80aromatic amino acid family metabolic process (GO:0009072)3.25293330
81S-adenosylmethionine metabolic process (GO:0046500)3.24536669
82alpha-amino acid catabolic process (GO:1901606)3.24284567
83fatty acid transmembrane transport (GO:1902001)3.22732538
84short-chain fatty acid metabolic process (GO:0046459)3.22018603
85cholesterol efflux (GO:0033344)3.21283836
86positive regulation of actin filament depolymerization (GO:0030836)3.20945241
87ethanol oxidation (GO:0006069)3.19797658
88epoxygenase P450 pathway (GO:0019373)3.17846883
89cellular amino acid catabolic process (GO:0009063)3.17753670
90phospholipid homeostasis (GO:0055091)3.16810610
91bile acid and bile salt transport (GO:0015721)3.15666149
92protein deneddylation (GO:0000338)3.15540299
93negative regulation of sterol transport (GO:0032372)3.14693902
94negative regulation of cholesterol transport (GO:0032375)3.14693902
95regulation of cholesterol homeostasis (GO:2000188)3.12327723
96branched-chain amino acid catabolic process (GO:0009083)3.11346435
97positive regulation of fatty acid metabolic process (GO:0045923)3.10275052
98regulation of cholesterol storage (GO:0010885)3.08880478
99aldehyde catabolic process (GO:0046185)3.07377640
100cellular modified amino acid catabolic process (GO:0042219)3.06607804
101carboxylic acid catabolic process (GO:0046395)3.06176297
102organic acid catabolic process (GO:0016054)3.06176297
103regulation of cholesterol metabolic process (GO:0090181)3.06101970
104negative regulation of lipase activity (GO:0060192)3.05139991
105signal peptide processing (GO:0006465)3.04875081
106positive regulation of triglyceride lipase activity (GO:0061365)3.03986496
107positive regulation of lipoprotein lipase activity (GO:0051006)3.03986496
108regulation of cholesterol biosynthetic process (GO:0045540)3.03607975
109branched-chain amino acid metabolic process (GO:0009081)3.03385055
110regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.02736711
111ketone body metabolic process (GO:1902224)3.02015649
112regulation of sulfur metabolic process (GO:0042762)3.00785613
113positive regulation of triglyceride metabolic process (GO:0090208)2.99042663
114peptidyl-cysteine modification (GO:0018198)2.98357014
115oxaloacetate metabolic process (GO:0006107)2.97169837
116glutamate metabolic process (GO:0006536)2.96220321
117negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.95180098
118cellular glucuronidation (GO:0052695)2.95090488
119biotin metabolic process (GO:0006768)2.94627808
120fibrinolysis (GO:0042730)2.94481422
121thioester biosynthetic process (GO:0035384)2.93437497
122acyl-CoA biosynthetic process (GO:0071616)2.93437497
123carnitine metabolic process (GO:0009437)2.92118469
124positive regulation of glycolytic process (GO:0045821)2.91572312
125regulation of acyl-CoA biosynthetic process (GO:0050812)2.91239385
126inositol phosphate catabolic process (GO:0071545)2.88576375
127DNA double-strand break processing (GO:0000729)2.85535970
128DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.85093983
129regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.82551727
130mannosylation (GO:0097502)2.82245880
131signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.77381467
132signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.77381467
133signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.77381467
134negative regulation of neurological system process (GO:0031645)2.75835462
135signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.74592532
136intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.74592532
137protein complex biogenesis (GO:0070271)2.73401170
138zinc ion transport (GO:0006829)2.71478258
139transepithelial transport (GO:0070633)2.71358263
140L-fucose metabolic process (GO:0042354)2.71208956
141L-fucose catabolic process (GO:0042355)2.71208956
142fucose catabolic process (GO:0019317)2.71208956
143glucuronate metabolic process (GO:0019585)2.68452583
144uronic acid metabolic process (GO:0006063)2.68452583
145tricarboxylic acid cycle (GO:0006099)2.64320155
146positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.62445315
147regulation of cofactor metabolic process (GO:0051193)2.57951200
148regulation of coenzyme metabolic process (GO:0051196)2.57951200
149signal transduction involved in DNA integrity checkpoint (GO:0072401)2.56199167
150signal transduction involved in DNA damage checkpoint (GO:0072422)2.56199167
151dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.56035123
152dopamine transport (GO:0015872)2.54626279
153vitamin biosynthetic process (GO:0009110)2.54544976
154UDP-N-acetylglucosamine metabolic process (GO:0006047)2.54424136
155arginine catabolic process (GO:0006527)2.54356678
156signal transduction involved in cell cycle checkpoint (GO:0072395)2.54316017
157polyol catabolic process (GO:0046174)2.54038560
158glutathione derivative metabolic process (GO:1901685)2.53231668
159glutathione derivative biosynthetic process (GO:1901687)2.53231668
160regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.52298118
161negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.50883882
162L-methionine salvage (GO:0071267)2.49594109
163L-methionine biosynthetic process (GO:0071265)2.49594109
164amino acid salvage (GO:0043102)2.49594109
165inositol phosphate dephosphorylation (GO:0046855)2.48777393
166phosphorylated carbohydrate dephosphorylation (GO:0046838)2.48777393
167sterol biosynthetic process (GO:0016126)2.48313558
168negative regulation of acute inflammatory response (GO:0002674)2.46047444
169mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.44628328
170kidney morphogenesis (GO:0060993)2.44620105
171mitochondrial respiratory chain complex assembly (GO:0033108)2.44420552
172isotype switching (GO:0045190)2.44198343
173somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.44198343
174somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.44198343
175cholesterol biosynthetic process (GO:0006695)2.43654653
176L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.43451966
177quinone metabolic process (GO:1901661)2.42903953
178detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.42874014
179nucleotide transmembrane transport (GO:1901679)2.42671821
180arginine metabolic process (GO:0006525)2.41948223
181heme transport (GO:0015886)2.41228122
182peptidyl-histidine modification (GO:0018202)2.40087687
183response to nitrosative stress (GO:0051409)2.39995012
184terpenoid biosynthetic process (GO:0016114)2.39383361
185peroxisome fission (GO:0016559)2.39357039
186purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.39130236
1873-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.39130236
188preassembly of GPI anchor in ER membrane (GO:0016254)2.38880959
189drug catabolic process (GO:0042737)2.36598205
190protein K6-linked ubiquitination (GO:0085020)2.35743532
191lipid particle organization (GO:0034389)2.33719517

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.90998361
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.52726660
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.74133108
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.95795983
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.70108941
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.78835340
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.76522171
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.40222486
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.08909213
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.99384623
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.94506871
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.68210100
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.66960288
14ZNF274_21170338_ChIP-Seq_K562_Hela2.59541534
15VDR_22108803_ChIP-Seq_LS180_Human2.57099886
16CLOCK_20551151_ChIP-Seq_293T_Human2.54305023
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.52599598
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.46698789
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35982869
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21752490
21ELK1_19687146_ChIP-ChIP_HELA_Human2.18797537
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.16701988
23GBX2_23144817_ChIP-Seq_PC3_Human2.11397511
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.09494008
25CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.03705693
26EST1_17652178_ChIP-ChIP_JURKAT_Human2.02541774
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.00776388
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.95473286
29P300_19829295_ChIP-Seq_ESCs_Human1.95084578
30FUS_26573619_Chip-Seq_HEK293_Human1.87809465
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79652011
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74410481
33ZNF263_19887448_ChIP-Seq_K562_Human1.71638033
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.67169339
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.66122515
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.65493095
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.65069680
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.63850358
39EZH2_27294783_Chip-Seq_NPCs_Mouse1.63232021
40TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.62633352
41TP63_17297297_ChIP-ChIP_HaCaT_Human1.61276993
42EWS_26573619_Chip-Seq_HEK293_Human1.60433994
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.57129765
44IGF1R_20145208_ChIP-Seq_DFB_Human1.57068848
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.55976899
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.55511677
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54086559
48HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.54084266
49CDX2_22108803_ChIP-Seq_LS180_Human1.52086760
50Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.51369318
51SOX2_19829295_ChIP-Seq_ESCs_Human1.48862459
52NANOG_19829295_ChIP-Seq_ESCs_Human1.48862459
53SOX2_27498859_Chip-Seq_STOMACH_Mouse1.44365042
54ER_23166858_ChIP-Seq_MCF-7_Human1.44118784
55STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42844836
56FOXA2_19822575_ChIP-Seq_HepG2_Human1.41987350
57TAF15_26573619_Chip-Seq_HEK293_Human1.41316606
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40301742
59TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.39541721
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38713647
61NRF2_20460467_ChIP-Seq_MEFs_Mouse1.37241269
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.37241269
63ESR1_21235772_ChIP-Seq_MCF-7_Human1.37078202
64SMAD4_21799915_ChIP-Seq_A2780_Human1.37070539
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35749498
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34525553
67CBP_20019798_ChIP-Seq_JUKART_Human1.34525553
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34482177
69RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.33405219
70ESR1_20079471_ChIP-ChIP_T-47D_Human1.33266450
71TCF4_22108803_ChIP-Seq_LS180_Human1.33123110
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32904054
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.32829017
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.32518569
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31598686
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30772616
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30596867
78ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30223258
79SOX2_20726797_ChIP-Seq_SW620_Human1.29634153
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28812785
81PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.28436035
82IRF8_22096565_ChIP-ChIP_GC-B_Human1.27119175
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26397415
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.26282528
85GATA1_22025678_ChIP-Seq_K562_Human1.26105120
86VDR_23849224_ChIP-Seq_CD4+_Human1.24120411
87PPAR_26484153_Chip-Seq_NCI-H1993_Human1.23824533
88BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.23652816
89FOXM1_26456572_ChIP-Seq_MCF-7_Human1.23378156
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.22967136
91P53_22387025_ChIP-Seq_ESCs_Mouse1.22777110
92AR_25329375_ChIP-Seq_VCAP_Human1.22604166
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22551459
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21260701
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20663289
96STAT3_18555785_Chip-Seq_ESCs_Mouse1.20511859
97FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20374580
98FOXA1_25329375_ChIP-Seq_VCAP_Human1.19988325
99FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19988325
100PHF8_20622853_ChIP-Seq_HELA_Human1.19535257
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19484249
102CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19277132
103SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18139582
104PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17744463
105FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17013420
106AR_20517297_ChIP-Seq_VCAP_Human1.16500459
107CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16185514
108FOXO3_23340844_ChIP-Seq_DLD1_Human1.15997190
109SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15182341
110SMAD3_21741376_ChIP-Seq_EPCs_Human1.14531100
111P300_18555785_Chip-Seq_ESCs_Mouse1.13635436
112GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13567833
113JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.13173329
114CMYC_18555785_Chip-Seq_ESCs_Mouse1.12930536
115NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12322740
116TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11534146
117FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11143006
118STAT3_23295773_ChIP-Seq_U87_Human1.10948578
119E2F1_18555785_Chip-Seq_ESCs_Mouse1.10839995
120SOX2_18555785_Chip-Seq_ESCs_Mouse1.10066757
121RBPJ_21746931_ChIP-Seq_IB4_Human1.09967451
122SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08961453
123ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08260742
124IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08097770
125GATA4_25053715_ChIP-Seq_YYC3_Human1.07666993
126RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07532378
127TP53_22573176_ChIP-Seq_HFKS_Human1.05856976
128HNFA_21074721_ChIP-Seq_CACO-2_Human1.04552022
129HNF4A_19822575_ChIP-Seq_HepG2_Human1.04205917
130TCF4_23295773_ChIP-Seq_U87_Human1.03543684
131OCT4_18555785_Chip-Seq_ESCs_Mouse1.03405436
132NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02943488
133MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02727901
134MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01886020
135PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.01873916
136TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98092516
137GATA2_21666600_ChIP-Seq_HMVEC_Human0.97188574
138AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.93433374
139CDX2_20551321_ChIP-Seq_CACO-2_Human0.93079698
140ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91629264
141TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91539023
142ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91016780
143CJUN_26792858_Chip-Seq_BT549_Human0.88338856
144PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.87897784
145HTT_18923047_ChIP-ChIP_STHdh_Human0.87761595
146EGR1_19032775_ChIP-ChIP_M12_Human0.85198809
147PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.83246536
148GATA2_19941826_ChIP-Seq_K562_Human0.82777458
149MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.82491313
150SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82379301
151NR3C1_23031785_ChIP-Seq_PC12_Mouse0.82095489
152ERG_21242973_ChIP-ChIP_JURKAT_Human0.81197354
153GATA1_19941826_ChIP-Seq_K562_Human0.80168100
154NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.79283788
155NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.77616650
156BCAT_22108803_ChIP-Seq_LS180_Human0.77530921
157RXR_22108803_ChIP-Seq_LS180_Human0.74816223
158GATA3_24758297_ChIP-Seq_MCF-7_Human0.74720093
159FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.73860620
160ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.73237002
161PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.72742311
162ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.72408688
163FOXA1_25552417_ChIP-Seq_VCAP_Human0.70188691
164SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.68077765
165PIAS1_25552417_ChIP-Seq_VCAP_Human0.68005519
166LXR_22292898_ChIP-Seq_THP-1_Human0.67933596
167RACK7_27058665_Chip-Seq_MCF-7_Human0.67614976
168TP63_23658742_ChIP-Seq_EP156T_Human0.66962991
169KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.66480810
170P63_26484246_Chip-Seq_KERATINOCYTES_Human0.66421288
171SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.66070596
172SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.66034680
173AHR_22903824_ChIP-Seq_MCF-7_Human0.65670032
174EP300_21415370_ChIP-Seq_HL-1_Mouse0.64875313
175FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.64087112
176SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.63753870
177TBX20_22328084_ChIP-Seq_HEART_Mouse0.63421606
178TBX20_22080862_ChIP-Seq_HEART_Mouse0.63421606
179GATA6_25053715_ChIP-Seq_YYC3_Human0.63355669
180ATF3_27146783_Chip-Seq_COLON_Human0.62688654
181JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.61074907
182SOX9_24532713_ChIP-Seq_HFSC_Mouse0.60775755
183GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.60055182
184RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59339930
185VDR_24787735_ChIP-Seq_THP-1_Human0.58899794
186JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.58842035
187SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.58552768
188AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.58289486
189BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.58212312

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.06028662
2MP0005360_urolithiasis5.46943348
3MP0005365_abnormal_bile_salt4.65282716
4MP0005085_abnormal_gallbladder_physiolo4.54258040
5MP0000372_irregular_coat_pigmentation4.07443683
6MP0008875_abnormal_xenobiotic_pharmacok3.82052509
7MP0010329_abnormal_lipoprotein_level3.46291405
8MP0003191_abnormal_cellular_cholesterol2.77298970
9MP0003252_abnormal_bile_duct2.70786801
10MP0002102_abnormal_ear_morphology2.63596588
11MP0003950_abnormal_plasma_membrane2.62988917
12MP0006054_spinal_hemorrhage2.58371803
13MP0001666_abnormal_nutrient_absorption2.55326745
14MP0009840_abnormal_foam_cell2.49590626
15MP0003806_abnormal_nucleotide_metabolis2.45925355
16MP0004130_abnormal_muscle_cell2.45751934
17MP0005332_abnormal_amino_acid2.34642873
18MP0005083_abnormal_biliary_tract2.33966920
19MP0000516_abnormal_urinary_system2.26272347
20MP0005367_renal/urinary_system_phenotyp2.26272347
21MP0002118_abnormal_lipid_homeostasis2.22204544
22MP0005408_hypopigmentation2.19903334
23MP0005670_abnormal_white_adipose2.19136294
24MP0005075_abnormal_melanosome_morpholog2.04873263
25MP0003195_calcinosis2.04576977
26MP0000609_abnormal_liver_physiology1.95459801
27MP0003705_abnormal_hypodermis_morpholog1.92610920
28MP0005174_abnormal_tail_pigmentation1.92585141
29MP0008877_abnormal_DNA_methylation1.91008694
30MP0010234_abnormal_vibrissa_follicle1.89902876
31MP0002876_abnormal_thyroid_physiology1.87299931
32MP0000015_abnormal_ear_pigmentation1.83610038
33MP0003718_maternal_effect1.81708842
34MP0002138_abnormal_hepatobiliary_system1.80806790
35MP0002938_white_spotting1.78928792
36MP0005379_endocrine/exocrine_gland_phen1.75040103
37MP0004019_abnormal_vitamin_homeostasis1.71898191
38MP0005666_abnormal_adipose_tissue1.69611068
39MP0005171_absent_coat_pigmentation1.68182058
40MP0002163_abnormal_gland_morphology1.61838478
41MP0009697_abnormal_copulation1.61243512
42MP0000569_abnormal_digit_pigmentation1.59702420
43MP0005319_abnormal_enzyme/_coenzyme1.59578143
44MP0004185_abnormal_adipocyte_glucose1.58437562
45MP0005584_abnormal_enzyme/coenzyme_acti1.57654803
46MP0002090_abnormal_vision1.57327828
47MP0002837_dystrophic_cardiac_calcinosis1.55846948
48MP0000604_amyloidosis1.54546352
49MP0003787_abnormal_imprinting1.53540428
50MP0003656_abnormal_erythrocyte_physiolo1.48614809
51MP0000427_abnormal_hair_cycle1.47215965
52MP0005551_abnormal_eye_electrophysiolog1.46010610
53MP0002254_reproductive_system_inflammat1.44942968
54MP0003786_premature_aging1.44836232
55MP0004043_abnormal_pH_regulation1.41153737
56MP0002971_abnormal_brown_adipose1.40552823
57MP0009643_abnormal_urine_homeostasis1.39854856
58MP0008438_abnormal_cutaneous_collagen1.37632673
59MP0005253_abnormal_eye_physiology1.37550610
60MP0003186_abnormal_redox_activity1.36508646
61MP0008058_abnormal_DNA_repair1.34225431
62MP0000013_abnormal_adipose_tissue1.33848692
63MP0001485_abnormal_pinna_reflex1.32644904
64MP0005275_abnormal_skin_tensile1.32619847
65MP0005535_abnormal_body_temperature1.31514849
66MP0001764_abnormal_homeostasis1.25487233
67MP0003011_delayed_dark_adaptation1.25461306
68MP0006072_abnormal_retinal_apoptosis1.23962191
69MP0003329_amyloid_beta_deposits1.22515758
70MP0005395_other_phenotype1.22067349
71MP0004215_abnormal_myocardial_fiber1.21304609
72MP0005375_adipose_tissue_phenotype1.20935236
73MP0001756_abnormal_urination1.20908608
74MP0005334_abnormal_fat_pad1.20879463
75MP0003724_increased_susceptibility_to1.19492055
76MP0009764_decreased_sensitivity_to1.18998699
77MP0003868_abnormal_feces_composition1.18414200
78MP0008775_abnormal_heart_ventricle1.18401110
79MP0010678_abnormal_skin_adnexa1.17603494
80MP0003136_yellow_coat_color1.17526253
81MP0001984_abnormal_olfaction1.17071138
82MP0000647_abnormal_sebaceous_gland1.15887420
83MP0003690_abnormal_glial_cell1.14570041
84MP0005220_abnormal_exocrine_pancreas1.14278722
85MP0005451_abnormal_body_composition1.13321331
86MP0002822_catalepsy1.12898364
87MP0005058_abnormal_lysosome_morphology1.10449019
88MP0005448_abnormal_energy_balance1.01824809
89MP0001324_abnormal_eye_pigmentation1.01552625
90MP0002078_abnormal_glucose_homeostasis1.01414688
91MP0005646_abnormal_pituitary_gland1.00081339
92MP0002095_abnormal_skin_pigmentation0.98753343
93MP0005645_abnormal_hypothalamus_physiol0.98635294
94MP0009115_abnormal_fat_cell0.98297754
95MP0002796_impaired_skin_barrier0.97961121
96MP0005636_abnormal_mineral_homeostasis0.97451145
97MP0000371_diluted_coat_color0.96866179
98MP0004484_altered_response_of0.95571355
99MP0010352_gastrointestinal_tract_polyps0.91262071
100MP0006035_abnormal_mitochondrial_morpho0.90053629
101MP0001986_abnormal_taste_sensitivity0.89932138
102MP0000598_abnormal_liver_morphology0.89866693
103MP0002638_abnormal_pupillary_reflex0.89510151
104MP0000003_abnormal_adipose_tissue0.86606222
105MP0005410_abnormal_fertilization0.85835492
106MP0003075_altered_response_to0.84559965
107MP0008469_abnormal_protein_level0.84463363
108MP0002909_abnormal_adrenal_gland0.83760564
109MP0001944_abnormal_pancreas_morphology0.83753657
110MP0000613_abnormal_salivary_gland0.83628818
111MP0005164_abnormal_response_to0.82384969
112MP0006036_abnormal_mitochondrial_physio0.82259312
113MP0009780_abnormal_chondrocyte_physiolo0.81054548
114MP0004147_increased_porphyrin_level0.80844326
115MP0000639_abnormal_adrenal_gland0.78883181
116MP0004381_abnormal_hair_follicle0.78794603
117MP0009642_abnormal_blood_homeostasis0.78714860
118MP0001881_abnormal_mammary_gland0.78055693
119MP0005167_abnormal_blood-brain_barrier0.78030735
120MP0003300_gastrointestinal_ulcer0.77736899
121MP0005084_abnormal_gallbladder_morpholo0.77311644
122MP0009763_increased_sensitivity_to0.77024663
123MP0010386_abnormal_urinary_bladder0.76805864
124MP0003959_abnormal_lean_body0.76766793
125MP0001661_extended_life_span0.76269697
126MP0005166_decreased_susceptibility_to0.75973990
127MP0003283_abnormal_digestive_organ0.75428545
128MP0003436_decreased_susceptibility_to0.73527411
129MP0003137_abnormal_impulse_conducting0.72886275
130MP0002060_abnormal_skin_morphology0.72267525
131MP0004883_abnormal_blood_vessel0.72182266
132MP0009046_muscle_twitch0.71941297
133MP0002693_abnormal_pancreas_physiology0.68744338
134MP0003646_muscle_fatigue0.68724324
135MP0002970_abnormal_white_adipose0.68190740
136MP0000538_abnormal_urinary_bladder0.68087326
137MP0000358_abnormal_cell_content/0.67330754
138MP0005376_homeostasis/metabolism_phenot0.67130999
139MP0005187_abnormal_penis_morphology0.66250503
140MP0002136_abnormal_kidney_physiology0.65339702
141MP0008007_abnormal_cellular_replicative0.65287582
142MP0003638_abnormal_response/metabolism_0.65275595
143MP0004085_abnormal_heartbeat0.64774161
144MP0000230_abnormal_systemic_arterial0.64671773
145MP0005647_abnormal_sex_gland0.64536156
146MP0001765_abnormal_ion_homeostasis0.63029439
147MP0005248_abnormal_Harderian_gland0.61730200
148MP0003183_abnormal_peptide_metabolism0.61100582
149MP0008874_decreased_physiological_sensi0.60832341
150MP0002168_other_aberrant_phenotype0.59774323
151MP0004264_abnormal_extraembryonic_tissu0.59636296
152MP0004782_abnormal_surfactant_physiolog0.59480288
153MP0001533_abnormal_skeleton_physiology0.58605723
154MP0003953_abnormal_hormone_level0.57920557
155MP0009765_abnormal_xenobiotic_induced0.57578128
156MP0008872_abnormal_physiological_respon0.57333222
157MP0004947_skin_inflammation0.56969120
158MP0000343_altered_response_to0.56854838
159MP0004858_abnormal_nervous_system0.56212333
160MP0001501_abnormal_sleep_pattern0.55800039
161MP0002295_abnormal_pulmonary_circulatio0.55242169
162MP0002166_altered_tumor_susceptibility0.54911302

Predicted human phenotypes

RankGene SetZ-score
1Xanthomatosis (HP:0000991)5.21091793
2Deep venous thrombosis (HP:0002625)5.19389678
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.96924163
4Intrahepatic cholestasis (HP:0001406)4.77082622
5Complement deficiency (HP:0004431)4.58347120
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.47736023
7Hyperlipoproteinemia (HP:0010980)4.34967857
8Prolonged partial thromboplastin time (HP:0003645)3.96444671
9Hyperglycinuria (HP:0003108)3.94366819
10Hypothermia (HP:0002045)3.86745153
11Abnormality of glutamine family amino acid metabolism (HP:0010902)3.85510066
12Hypobetalipoproteinemia (HP:0003563)3.83142391
13Hyperammonemia (HP:0001987)3.81248580
14Epidermoid cyst (HP:0200040)3.73584032
15Hypoalphalipoproteinemia (HP:0003233)3.68944402
16Ketosis (HP:0001946)3.61612675
17Abnormality of serine family amino acid metabolism (HP:0010894)3.56896098
18Abnormality of glycine metabolism (HP:0010895)3.56896098
19Abnormality of fatty-acid metabolism (HP:0004359)3.54307536
20Hypolipoproteinemia (HP:0010981)3.52533983
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.40938752
22Abnormality of the common coagulation pathway (HP:0010990)3.36449855
23Acute encephalopathy (HP:0006846)3.32519830
24Hypoglycemic coma (HP:0001325)3.31501093
25Hyperglycinemia (HP:0002154)3.29866888
26Abnormality of complement system (HP:0005339)3.28978698
27Myocardial infarction (HP:0001658)3.22828815
28Progressive macrocephaly (HP:0004481)3.21166099
29Acute necrotizing encephalopathy (HP:0006965)3.16278559
30Oligomenorrhea (HP:0000876)3.16027497
31Joint hemorrhage (HP:0005261)3.12100394
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.11691901
33Fat malabsorption (HP:0002630)3.00724364
34Ketoacidosis (HP:0001993)2.99618630
35Abnormality of sulfur amino acid metabolism (HP:0004339)2.94574518
36Hyperinsulinemic hypoglycemia (HP:0000825)2.93457816
37Skin nodule (HP:0200036)2.91879989
38Increased CSF lactate (HP:0002490)2.88277246
39Hypoplasia of the fovea (HP:0007750)2.86313876
40Aplasia/Hypoplasia of the fovea (HP:0008060)2.86313876
41Abnormality of glycolysis (HP:0004366)2.85167753
42Abnormality of the intrinsic pathway (HP:0010989)2.82229531
43Hypercholesterolemia (HP:0003124)2.80787230
44Hepatic necrosis (HP:0002605)2.79974838
45Abnormality of purine metabolism (HP:0004352)2.78308449
46Abnormality of aspartate family amino acid metabolism (HP:0010899)2.77620652
47Abnormality of proline metabolism (HP:0010907)2.73846688
48Hydroxyprolinuria (HP:0003080)2.73846688
49Mitochondrial inheritance (HP:0001427)2.73196192
50Methylmalonic acidemia (HP:0002912)2.70090548
51Abnormality of vitamin B metabolism (HP:0004340)2.69676687
52Neoplasm of the adrenal gland (HP:0100631)2.69122216
53Increased serum pyruvate (HP:0003542)2.68500885
54Abnormal mitochondria in muscle tissue (HP:0008316)2.68125628
55Gout (HP:0001997)2.67866052
56Systemic lupus erythematosus (HP:0002725)2.60316723
57Albinism (HP:0001022)2.57272821
58Hepatocellular necrosis (HP:0001404)2.52043530
59Conjugated hyperbilirubinemia (HP:0002908)2.51057760
60Tongue fasciculations (HP:0001308)2.47909982
61Sensorimotor neuropathy (HP:0007141)2.44939623
62Pancreatic cysts (HP:0001737)2.44092486
63Abnormality of methionine metabolism (HP:0010901)2.42534050
64Dicarboxylic aciduria (HP:0003215)2.42379401
65Abnormality of dicarboxylic acid metabolism (HP:0010995)2.42379401
66Hypertriglyceridemia (HP:0002155)2.41949478
67Abnormality of nucleobase metabolism (HP:0010932)2.41778650
68Hamartoma of the eye (HP:0010568)2.38763573
69Abnormality of urine glucose concentration (HP:0011016)2.38372026
70Glycosuria (HP:0003076)2.38372026
71Hemorrhage of the eye (HP:0011885)2.37674577
72Abnormality of the fovea (HP:0000493)2.36938927
73Amyloidosis (HP:0011034)2.35889016
74Methylmalonic aciduria (HP:0012120)2.35746448
75Pancreatitis (HP:0001733)2.35555666
76Metabolic acidosis (HP:0001942)2.33510931
77Recurrent gram-negative bacterial infections (HP:0005420)2.32298194
78Hypomagnesemia (HP:0002917)2.32180811
79Symptomatic seizures (HP:0011145)2.31391398
80Abnormality of the vitamin B12 metabolism (HP:0004341)2.30653689
81Patchy hypopigmentation of hair (HP:0011365)2.29989288
82Hepatocellular carcinoma (HP:0001402)2.29319994
83Steatorrhea (HP:0002570)2.28715532
84Abnormal gallbladder morphology (HP:0012437)2.27624080
85Abnormality of the renal cortex (HP:0011035)2.26677016
86Cholelithiasis (HP:0001081)2.26099583
87Acanthosis nigricans (HP:0000956)2.25528348
88Disproportionate short-trunk short stature (HP:0003521)2.23605984
89Hyperbilirubinemia (HP:0002904)2.23100097
90Neonatal onset (HP:0003623)2.22673806
91Lethargy (HP:0001254)2.21771683
92Type I transferrin isoform profile (HP:0003642)2.21156660
93Posterior subcapsular cataract (HP:0007787)2.19596405
94Cerebral hemorrhage (HP:0001342)2.18399922
95Congenital sensorineural hearing impairment (HP:0008527)2.16405071
96Nausea (HP:0002018)2.15887026
97Spontaneous abortion (HP:0005268)2.14999864
98Large for gestational age (HP:0001520)2.14237018
99Abnormality of endocrine pancreas physiology (HP:0012093)2.14153988
100Abnormality of the pancreatic islet cells (HP:0006476)2.14153988
101Neoplasm of the adrenal cortex (HP:0100641)2.13784092
102Abnormal cartilage morphology (HP:0002763)2.13710118
103Cholecystitis (HP:0001082)2.13586929
104Abnormal gallbladder physiology (HP:0012438)2.13586929
105Axonal loss (HP:0003447)2.13214837
106Pancreatic fibrosis (HP:0100732)2.12027215
107Hyperalaninemia (HP:0003348)2.11194301
108Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.11194301
109Abnormality of alanine metabolism (HP:0010916)2.11194301
110Renal cortical cysts (HP:0000803)2.09513720
111Congenital stationary night blindness (HP:0007642)2.08912345
112Intestinal atresia (HP:0011100)2.08828283
113Abnormality of serum amino acid levels (HP:0003112)2.07909651
114Ileus (HP:0002595)2.07887718
115Lactic acidosis (HP:0003128)2.06806322
116Abnormal protein glycosylation (HP:0012346)2.06780909
117Abnormal glycosylation (HP:0012345)2.06780909
118Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.06780909
119Abnormal protein N-linked glycosylation (HP:0012347)2.06780909
120Esophageal varix (HP:0002040)2.06662486
121Ependymoma (HP:0002888)2.05284030
122Abnormality of vitamin metabolism (HP:0100508)2.04761806
123Pancreatic islet-cell hyperplasia (HP:0004510)2.04751220
124Cerebral edema (HP:0002181)2.04548830
125Vomiting (HP:0002013)2.03697037
126Medial flaring of the eyebrow (HP:0010747)2.03387022
127Respiratory failure (HP:0002878)2.03372710
128True hermaphroditism (HP:0010459)2.03114938
129White forelock (HP:0002211)2.02662912
130Palpitations (HP:0001962)2.00810565
131Hyperuricemia (HP:0002149)2.00060914
132Increased purine levels (HP:0004368)2.00060914
133Generalized aminoaciduria (HP:0002909)1.99672972
134Vascular calcification (HP:0004934)1.99233670
135Right ventricular cardiomyopathy (HP:0011663)1.98387306
136Muscle fibrillation (HP:0010546)1.97804393
137Cutaneous melanoma (HP:0012056)1.97217704
138Mitral stenosis (HP:0001718)1.96898071
139Adrenal hypoplasia (HP:0000835)1.95360235
140Breast carcinoma (HP:0003002)1.94359609
141Irritability (HP:0000737)1.94185117
142Increased serum lactate (HP:0002151)1.93914409
143Insulin-resistant diabetes mellitus (HP:0000831)1.93677671
144Glomerulonephritis (HP:0000099)1.92722153
145Cardiovascular calcification (HP:0011915)1.90382849
146Abolished electroretinogram (ERG) (HP:0000550)1.89307421
147Aplasia/Hypoplasia of the macula (HP:0008059)1.89130268
148Late onset (HP:0003584)1.88711593
149Myoglobinuria (HP:0002913)1.88327833
150CNS demyelination (HP:0007305)1.87767919
151Delayed CNS myelination (HP:0002188)1.86401094
152Decreased electroretinogram (ERG) amplitude (HP:0000654)1.86129212
153Malnutrition (HP:0004395)1.85932010
154Acanthocytosis (HP:0001927)1.85691168
155Thyroiditis (HP:0100646)1.84804163
156Hypokinesia (HP:0002375)1.84325256
157Polycythemia (HP:0001901)1.83278805
158Conjunctival hamartoma (HP:0100780)1.82636910
159Abnormality of magnesium homeostasis (HP:0004921)1.82604484
160Progressive inability to walk (HP:0002505)1.82530333
161Hyperglycemia (HP:0003074)1.81195405
162Increased hepatocellular lipid droplets (HP:0006565)1.78801749
163Delayed gross motor development (HP:0002194)1.78280968
164Spastic diplegia (HP:0001264)1.77348226
165Aplasia/Hypoplasia affecting the retina (HP:0008061)1.77261014
166Metaphyseal dysplasia (HP:0100255)1.77009730
167Abnormality of the gallbladder (HP:0005264)1.76399508
168Nephritis (HP:0000123)1.76190340
169Abnormal pancreas size (HP:0012094)1.75437458
170Growth hormone excess (HP:0000845)1.74316795
171Brushfield spots (HP:0001088)1.73219572
172Hypoglycemic seizures (HP:0002173)1.71772790
173Alkalosis (HP:0001948)1.69616719
174Abnormality of pyrimidine metabolism (HP:0004353)1.68719054
175Vacuolated lymphocytes (HP:0001922)1.67994273
176Protuberant abdomen (HP:0001538)1.64613445
177Peritonitis (HP:0002586)1.62211370

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.21176863
2TRIB33.68624647
3TRIM283.47962849
4ERN13.44019946
5EIF2AK32.93950271
6ACVR1B2.78489625
7FRK2.74362386
8SIK12.70348658
9MST1R2.61537236
10BMPR1B2.53919400
11WNK32.32792767
12FGFR42.30109034
13NUAK12.27678914
14MAP4K22.09517325
15STK392.08195012
16ERBB32.07289129
17MAP3K22.01732090
18PLK22.00219614
19EIF2AK11.96308036
20MAP2K41.93508200
21GRK11.92224599
22MAP3K121.78383148
23DAPK21.73157507
24KSR21.71696462
25MKNK21.67910218
26LMTK21.62995820
27BRSK21.57624420
28PLK31.56797766
29TNIK1.56745909
30BCR1.54078268
31CAMK1D1.53610369
32MAP2K11.49923088
33PDK21.49453072
34NTRK11.47433582
35SIK31.43510337
36RIPK11.43336787
37PDK31.41753616
38PDK41.41753616
39MAPKAPK31.39857932
40STK38L1.39274104
41PKN21.38971908
42MYLK1.36272064
43TAOK31.33922146
44NEK91.30238951
45BUB11.27271705
46ADRBK21.26375303
47ARAF1.25886256
48FER1.25590731
49ZAK1.25098426
50PBK1.23562929
51TBK11.22984555
52CASK1.20868384
53ERBB41.18489143
54LATS11.17739852
55CSNK1G11.16538034
56MKNK11.15915592
57PTK61.13811650
58JAK11.08941125
59MAP3K31.06129923
60INSRR1.05938905
61CSNK1G31.05612486
62JAK21.05386127
63EPHB11.05364914
64PDPK11.03547550
65PHKG21.01966794
66PHKG11.01966794
67PRKCE1.00536757
68PRKCI1.00319573
69CSNK1G20.99053724
70STK30.98922209
71RET0.98623820
72VRK20.96465415
73TRPM70.95967517
74TSSK60.94933286
75PINK10.94112747
76CAMK1G0.92795149
77MAPK110.92760817
78ABL20.92175616
79LATS20.91674487
80FGFR30.91041888
81PIK3CG0.89115342
82NEK10.88418237
83PIK3CA0.87543221
84TYK20.82679127
85RIPK40.82530564
86PRKAA20.81376938
87FGFR20.81059261
88MAP2K30.80463345
89LIMK10.80042961
90PTK20.79784866
91MAP3K10.79545742
92MET0.79312597
93CSNK1A1L0.78960789
94AKT30.78851954
95MAP3K90.78793033
96WEE10.78306007
97STK240.77721229
98PDK10.77334530
99BMPR20.73793678
100LRRK20.73670903
101MST40.73249028
102MAP3K110.72600094
103MAPK130.71940391
104GRK50.71259729
105NLK0.71067885
106IRAK30.70754788
107MINK10.68364132
108EPHA30.67600634
109OXSR10.66057809
110PDGFRA0.63525981
111CAMKK20.62745205
112PLK40.62585554
113WNK40.61924800
114GRK60.61602383
115CAMKK10.61552704
116STK160.61305695
117SGK30.60349875
118TIE10.59243721
119MAPKAPK50.59242216
120STK100.59229527
121TGFBR10.58378003
122PRKCH0.57600234
123BMX0.57387571
124TTN0.56901081
125EEF2K0.56213337
126MAP2K20.55960213
127ADRBK10.55548874
128EPHB20.54417676
129BRSK10.53371612
130FLT30.53182282
131PRKACG0.52282168
132CAMK2G0.51397982
133ROCK10.50954429
134PRKCG0.50834360
135RPS6KA20.50557699
136PRKAA10.49574360
137EIF2AK20.49535702
138OBSCN0.49233517
139GSK3A0.48254992
140PAK30.47624544
141PTK2B0.47449050
142CDK60.47138101
143TAF10.46822306
144DAPK30.46332923
145SGK2230.46328822
146SGK4940.46328822
147PRKCZ0.46086861
148TGFBR20.44973446
149PLK10.44798868
150IGF1R0.44086348
151ZAP700.43624888
152IRAK40.43444452
153MAPK120.43265209
154CAMK2D0.40378909
155NTRK30.39310354
156DAPK10.39228040
157EPHA20.38762245
158TTK0.36232346
159MAP3K140.35998806
160VRK10.35435004
161MAP3K40.33958006
162FGFR10.33803272
163DDR20.33300870
164CSNK1A10.31658302
165ABL10.30535756
166CAMK2A0.27544827
167ATM0.24640881
168TEC0.24580656

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.47242797
2Nitrogen metabolism_Homo sapiens_hsa009103.18127484
3Proteasome_Homo sapiens_hsa030503.13171821
4Protein export_Homo sapiens_hsa030603.10147785
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.90554897
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.70376871
7Fatty acid degradation_Homo sapiens_hsa000712.66504820
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.60701488
9Arginine biosynthesis_Homo sapiens_hsa002202.58351809
10PPAR signaling pathway_Homo sapiens_hsa033202.47710362
11Propanoate metabolism_Homo sapiens_hsa006402.45306922
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.41433119
13Tryptophan metabolism_Homo sapiens_hsa003802.32247835
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.31959190
15Complement and coagulation cascades_Homo sapiens_hsa046102.17355032
16Fatty acid metabolism_Homo sapiens_hsa012122.14262889
17Caffeine metabolism_Homo sapiens_hsa002322.11036652
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.97634304
19Butanoate metabolism_Homo sapiens_hsa006501.96908546
20Peroxisome_Homo sapiens_hsa041461.84475789
21Sulfur metabolism_Homo sapiens_hsa009201.74716765
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.74452252
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.73103254
24Pyruvate metabolism_Homo sapiens_hsa006201.72606941
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.72483031
26beta-Alanine metabolism_Homo sapiens_hsa004101.71857015
27Histidine metabolism_Homo sapiens_hsa003401.69492872
28Oxidative phosphorylation_Homo sapiens_hsa001901.67596177
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.64830437
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62325905
31Phenylalanine metabolism_Homo sapiens_hsa003601.61752853
32Staphylococcus aureus infection_Homo sapiens_hsa051501.58439187
33Fat digestion and absorption_Homo sapiens_hsa049751.50665844
34Non-homologous end-joining_Homo sapiens_hsa034501.49636648
35Chemical carcinogenesis_Homo sapiens_hsa052041.44292250
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.42517909
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.41712332
38Bile secretion_Homo sapiens_hsa049761.41330517
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36505100
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.34442882
41Tyrosine metabolism_Homo sapiens_hsa003501.32227696
42Carbon metabolism_Homo sapiens_hsa012001.31563276
43Glycerolipid metabolism_Homo sapiens_hsa005611.26577787
44Fatty acid biosynthesis_Homo sapiens_hsa000611.25364301
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.24778589
46Fatty acid elongation_Homo sapiens_hsa000621.19792845
47Parkinsons disease_Homo sapiens_hsa050121.17674420
48Starch and sucrose metabolism_Homo sapiens_hsa005001.17225978
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.16998106
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.16209215
51Retinol metabolism_Homo sapiens_hsa008301.09864630
52RNA polymerase_Homo sapiens_hsa030201.03337013
53Basal transcription factors_Homo sapiens_hsa030221.01762683
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01116035
55Drug metabolism - other enzymes_Homo sapiens_hsa009831.00392648
56Phototransduction_Homo sapiens_hsa047440.96696785
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96438582
58ABC transporters_Homo sapiens_hsa020100.93365833
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92531572
60Biosynthesis of amino acids_Homo sapiens_hsa012300.89507611
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81607233
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.80052370
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.80050533
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.79760259
65Ether lipid metabolism_Homo sapiens_hsa005650.78354294
66Steroid biosynthesis_Homo sapiens_hsa001000.78021739
67Sphingolipid metabolism_Homo sapiens_hsa006000.77455880
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75585806
69Arachidonic acid metabolism_Homo sapiens_hsa005900.74598846
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74550959
71One carbon pool by folate_Homo sapiens_hsa006700.73414805
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72029727
73Folate biosynthesis_Homo sapiens_hsa007900.71220074
74Vitamin B6 metabolism_Homo sapiens_hsa007500.71083139
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69967905
76RNA degradation_Homo sapiens_hsa030180.69171999
77Alzheimers disease_Homo sapiens_hsa050100.68229705
78Homologous recombination_Homo sapiens_hsa034400.66446135
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65373279
80Selenocompound metabolism_Homo sapiens_hsa004500.61406920
81Vitamin digestion and absorption_Homo sapiens_hsa049770.60935500
82Arginine and proline metabolism_Homo sapiens_hsa003300.59960564
83Huntingtons disease_Homo sapiens_hsa050160.58848173
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56536544
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55899422
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55861867
87Fanconi anemia pathway_Homo sapiens_hsa034600.55845735
88Pentose phosphate pathway_Homo sapiens_hsa000300.52538589
89Insulin resistance_Homo sapiens_hsa049310.52471995
90Sulfur relay system_Homo sapiens_hsa041220.51050250
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50807843
92Glutathione metabolism_Homo sapiens_hsa004800.50154105
93Purine metabolism_Homo sapiens_hsa002300.46894729
94Circadian rhythm_Homo sapiens_hsa047100.46838896
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.43452127
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43451119
97N-Glycan biosynthesis_Homo sapiens_hsa005100.42792814
98Fructose and mannose metabolism_Homo sapiens_hsa000510.42547172
99AMPK signaling pathway_Homo sapiens_hsa041520.41723216
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.41072695
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.40771696
102Collecting duct acid secretion_Homo sapiens_hsa049660.40655829
103Prion diseases_Homo sapiens_hsa050200.40234276
104Insulin secretion_Homo sapiens_hsa049110.37353349
105Lysosome_Homo sapiens_hsa041420.34906582
106Glucagon signaling pathway_Homo sapiens_hsa049220.31842673
107Mismatch repair_Homo sapiens_hsa034300.31815604
108Metabolic pathways_Homo sapiens_hsa011000.31620384
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30724646
110Insulin signaling pathway_Homo sapiens_hsa049100.28812213
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27869961
112Renin-angiotensin system_Homo sapiens_hsa046140.26791957
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23187943
114Galactose metabolism_Homo sapiens_hsa000520.22132210
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.21445992
116Pertussis_Homo sapiens_hsa051330.20796093
117Mineral absorption_Homo sapiens_hsa049780.20134370
118Lysine degradation_Homo sapiens_hsa003100.18299941
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.14176959
120Amoebiasis_Homo sapiens_hsa051460.13617677
121Thyroid hormone synthesis_Homo sapiens_hsa049180.13170130
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.12453481
123Vibrio cholerae infection_Homo sapiens_hsa051100.11879602
124Synaptic vesicle cycle_Homo sapiens_hsa047210.11720394
125Regulation of autophagy_Homo sapiens_hsa041400.10433195
126Protein digestion and absorption_Homo sapiens_hsa049740.10091723
127Phagosome_Homo sapiens_hsa041450.09531513
128Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.07069570
129Linoleic acid metabolism_Homo sapiens_hsa005910.06764278
130Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.06143706
131Rheumatoid arthritis_Homo sapiens_hsa053230.05851521
132Hepatitis C_Homo sapiens_hsa051600.05469855
133Renin secretion_Homo sapiens_hsa049240.03848452
134Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.03482499

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