CHP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product is a small calcium-binding protein that regulates cell pH by controlling plasma membrane-type Na+/H+ exchange activity. This protein shares sequence similarity with calcineurin B and can bind to and stimulate the protein phosphatase activity of calcineurin A (CnA) and functions in the calcineurin/NFAT (nuclear factor of activated T cells) signaling pathway. Another member of the CHP subfamily, Calcineurin B homologous protein 1, is located on Chromosome 15 and is an inhibitor of calcineurin activity and has a genetic phenotype associated with Parkinson's Disease (OMIM:606988). This gene was initially identified as a tumor-associated antigen and was previously referred to as Hepatocellular carcinoma-associated antigen 520. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal cholesterol absorption (GO:0030299)9.59597180
2angiotensin maturation (GO:0002003)8.64959520
3regulation of guanylate cyclase activity (GO:0031282)7.91841548
4vitamin A metabolic process (GO:0006776)6.48229901
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.35565016
6phospholipid efflux (GO:0033700)6.01652435
7flavonoid metabolic process (GO:0009812)6.00708481
8regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.99881711
9positive regulation of guanylate cyclase activity (GO:0031284)5.99771562
10fat-soluble vitamin biosynthetic process (GO:0042362)5.80687550
11NADH metabolic process (GO:0006734)5.66811853
12regulation of cholesterol esterification (GO:0010872)5.51287226
13regulation of triglyceride catabolic process (GO:0010896)5.48111151
14virion attachment to host cell (GO:0019062)5.39992403
15adhesion of symbiont to host cell (GO:0044650)5.39992403
16positive regulation of lipoprotein lipase activity (GO:0051006)5.27138603
17positive regulation of triglyceride lipase activity (GO:0061365)5.27138603
18plasma lipoprotein particle assembly (GO:0034377)5.20784038
19drug catabolic process (GO:0042737)5.20591918
20uronic acid metabolic process (GO:0006063)4.98655322
21glucuronate metabolic process (GO:0019585)4.98655322
22adhesion of symbiont to host (GO:0044406)4.94207427
23lipoprotein metabolic process (GO:0042157)4.93246534
24reverse cholesterol transport (GO:0043691)4.90799758
25purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.89986927
263-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.89986927
27protein-lipid complex assembly (GO:0065005)4.87886966
28cholesterol efflux (GO:0033344)4.87130696
29regulation of cGMP biosynthetic process (GO:0030826)4.83502547
30regulation of cellular extravasation (GO:0002691)4.77322017
31regulation of systemic arterial blood pressure (GO:0003073)4.72013814
32vitamin transmembrane transport (GO:0035461)4.67503696
33digestive system process (GO:0022600)4.63603800
34fructose metabolic process (GO:0006000)4.47069499
35renal system process involved in regulation of blood volume (GO:0001977)4.46997773
36actin filament depolymerization (GO:0030042)4.41210015
37high-density lipoprotein particle remodeling (GO:0034375)4.18165146
38hormone catabolic process (GO:0042447)4.14614778
39cholesterol homeostasis (GO:0042632)4.07394166
40regulation of vitamin metabolic process (GO:0030656)4.05895192
41negative regulation of sterol transport (GO:0032372)4.04822403
42negative regulation of cholesterol transport (GO:0032375)4.04822403
43lipoprotein transport (GO:0042953)4.04568364
44modified amino acid transport (GO:0072337)4.04507500
45sterol transport (GO:0015918)4.03856282
46cholesterol transport (GO:0030301)4.03856282
47sterol homeostasis (GO:0055092)4.02655631
48diacylglycerol metabolic process (GO:0046339)4.00923076
49sulfate transmembrane transport (GO:1902358)3.99977204
50regulation of cGMP metabolic process (GO:0030823)3.99107060
51very-low-density lipoprotein particle assembly (GO:0034379)3.98069186
52transcytosis (GO:0045056)3.97443643
53bundle of His cell to Purkinje myocyte communication (GO:0086069)3.95387138
54regulation of bile acid biosynthetic process (GO:0070857)3.90699791
55positive regulation of glycoprotein biosynthetic process (GO:0010560)3.89939422
56antibacterial humoral response (GO:0019731)3.88471074
57alkaloid metabolic process (GO:0009820)3.85389122
58positive regulation of respiratory burst (GO:0060267)3.84736853
59positive regulation of fatty acid biosynthetic process (GO:0045723)3.83487290
60sulfation (GO:0051923)3.80397630
61macromolecular complex remodeling (GO:0034367)3.79466653
62plasma lipoprotein particle remodeling (GO:0034369)3.79466653
63protein-lipid complex remodeling (GO:0034368)3.79466653
64positive regulation of pseudopodium assembly (GO:0031274)3.79406717
65UDP-N-acetylglucosamine metabolic process (GO:0006047)3.77963572
66antimicrobial humoral response (GO:0019730)3.76593620
67ethanol oxidation (GO:0006069)3.70843496
68phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.68394511
69calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.66311930
70bile acid and bile salt transport (GO:0015721)3.59509338
71glucose 6-phosphate metabolic process (GO:0051156)3.59149038
72peptide hormone processing (GO:0016486)3.57023849
73plasma lipoprotein particle organization (GO:0071827)3.55972988
74positive regulation of lipid catabolic process (GO:0050996)3.55658673
75positive regulation of triglyceride metabolic process (GO:0090208)3.50638137
76phospholipid homeostasis (GO:0055091)3.49798417
77positive regulation of cGMP biosynthetic process (GO:0030828)3.48996500
78cGMP biosynthetic process (GO:0006182)3.48654162
79response to hepatocyte growth factor (GO:0035728)3.48422911
80cellular response to hepatocyte growth factor stimulus (GO:0035729)3.48422911
81protein-lipid complex subunit organization (GO:0071825)3.47504434
82vitamin transport (GO:0051180)3.45946608
83positive regulation of glycoprotein metabolic process (GO:1903020)3.44391388
84glycosylceramide metabolic process (GO:0006677)3.40522666
85bicarbonate transport (GO:0015701)3.39305945
86regulation of pseudopodium assembly (GO:0031272)3.38461738
87digestion (GO:0007586)3.37886233
88drinking behavior (GO:0042756)3.37441251
89glycerol metabolic process (GO:0006071)3.34518896
90oligosaccharide biosynthetic process (GO:0009312)3.31202810
91thyroid hormone metabolic process (GO:0042403)3.29685394
92regulation of cholesterol homeostasis (GO:2000188)3.29670556
93glycolipid catabolic process (GO:0019377)3.27602428
94arginine metabolic process (GO:0006525)3.27327838
95sulfur compound transport (GO:0072348)3.23771984
96glycosphingolipid catabolic process (GO:0046479)3.22950190
97response to hydroperoxide (GO:0033194)3.22664728
98negative regulation of digestive system process (GO:0060457)3.22474793
99maintenance of gastrointestinal epithelium (GO:0030277)3.22096513
100cGMP-mediated signaling (GO:0019934)3.21953400
101regulation of protein glycosylation (GO:0060049)3.21858408
102sulfate transport (GO:0008272)3.20795565
103auditory receptor cell differentiation (GO:0042491)3.20794868
104bile acid metabolic process (GO:0008206)3.19454852
105phosphatidylserine acyl-chain remodeling (GO:0036150)3.18956966
106regulation of sterol transport (GO:0032371)3.17204728
107regulation of cholesterol transport (GO:0032374)3.17204728
108exogenous drug catabolic process (GO:0042738)3.15834213
109drug transport (GO:0015893)3.15667453
110fat-soluble vitamin metabolic process (GO:0006775)3.15654073
111purine nucleotide salvage (GO:0032261)3.15576974
112regulation of lipoprotein metabolic process (GO:0050746)3.15306391
113ethanol metabolic process (GO:0006067)3.15240378
114receptor guanylyl cyclase signaling pathway (GO:0007168)3.12650999
115peptide catabolic process (GO:0043171)3.11413432
116vitamin biosynthetic process (GO:0009110)3.10851713
117glomerular filtration (GO:0003094)3.10660969
118renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.06754408
119triglyceride homeostasis (GO:0070328)3.06711476
120acylglycerol homeostasis (GO:0055090)3.06711476
121urea metabolic process (GO:0019627)3.05697897
122urea cycle (GO:0000050)3.05697897
123sphingomyelin metabolic process (GO:0006684)3.03490657
124sperm capacitation (GO:0048240)3.03000960
125leukotriene metabolic process (GO:0006691)3.02189990
126drug transmembrane transport (GO:0006855)2.99558199
127lipid homeostasis (GO:0055088)2.99073949
128regulation of digestive system process (GO:0044058)2.98408156
129cellular response to nitric oxide (GO:0071732)2.97630524
130drug metabolic process (GO:0017144)2.97093129
131quinone biosynthetic process (GO:1901663)2.96872469
132sodium ion homeostasis (GO:0055078)2.95233998
133excretion (GO:0007588)2.95056379
134transepithelial transport (GO:0070633)2.95055109
135thrombin receptor signaling pathway (GO:0070493)2.95045417
136alditol metabolic process (GO:0019400)2.94456930
137cobalamin metabolic process (GO:0009235)2.93498935
138regulation of systemic arterial blood pressure by hormone (GO:0001990)2.92718264
139regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.92718264
140endocrine process (GO:0050886)2.92718264
141epoxygenase P450 pathway (GO:0019373)2.88735997
142plasma lipoprotein particle clearance (GO:0034381)2.87468875
143nucleobase catabolic process (GO:0046113)2.84127070
144response to phenylpropanoid (GO:0080184)2.81639313
145cytidine deamination (GO:0009972)2.80964475
146cytidine metabolic process (GO:0046087)2.80964475
147cytidine catabolic process (GO:0006216)2.80964475
148O-glycan processing (GO:0016266)2.79890799
149low-density lipoprotein particle clearance (GO:0034383)2.78018101
150cellular glucuronidation (GO:0052695)2.76367484
151nitrogen cycle metabolic process (GO:0071941)2.72938296
152homocysteine metabolic process (GO:0050667)2.62359086
153intestinal absorption (GO:0050892)10.6027866

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.49162912
2CDX2_20551321_ChIP-Seq_CACO-2_Human4.14023768
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.12204157
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.24814914
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.22018722
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.16143545
7SOX2_27498859_Chip-Seq_STOMACH_Mouse2.98448113
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.90012215
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.66609360
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.56092050
11GATA4_25053715_ChIP-Seq_YYC3_Human2.45421922
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.42015914
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.31731168
14SOX2_20726797_ChIP-Seq_SW620_Human2.17115237
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.10746179
16GATA6_25053715_ChIP-Seq_YYC3_Human2.08932149
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.04250476
18EGR1_23403033_ChIP-Seq_LIVER_Mouse2.04157491
19CLOCK_20551151_ChIP-Seq_293T_Human2.01037464
20PPAR_26484153_Chip-Seq_NCI-H1993_Human1.85225290
21NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.84342420
22CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.81308375
23FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.70533478
24BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.66626857
25ESR1_20079471_ChIP-ChIP_T-47D_Human1.61053808
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.57048605
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.53267593
28FOXO3_23340844_ChIP-Seq_DLD1_Human1.47852793
29RXR_22108803_ChIP-Seq_LS180_Human1.46824955
30NR3C1_21868756_ChIP-Seq_MCF10A_Human1.42551034
31RUNX1_27514584_Chip-Seq_MCF-7_Human1.42159824
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.39918673
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39329224
34TCF4_18268006_ChIP-ChIP_LS174T_Human1.38931045
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38472876
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33851585
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.33756960
38GATA2_19941826_ChIP-Seq_K562_Human1.33409059
39FOXA2_19822575_ChIP-Seq_HepG2_Human1.32588081
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31688480
41KLF5_25053715_ChIP-Seq_YYC3_Human1.31351042
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29230396
43FOXA1_21572438_ChIP-Seq_LNCaP_Human1.29158052
44HNF4A_19822575_ChIP-Seq_HepG2_Human1.26563040
45CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.25659371
46KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25603787
47ZNF263_19887448_ChIP-Seq_K562_Human1.25493112
48* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25177139
49NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.23900107
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22440002
51ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21997429
52RACK7_27058665_Chip-Seq_MCF-7_Human1.20575909
53CEBPB_22108803_ChIP-Seq_LS180_Human1.19199081
54BP1_19119308_ChIP-ChIP_Hs578T_Human1.19076414
55SALL4_18804426_ChIP-ChIP_XEN_Mouse1.18799519
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16931179
57RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16851098
58SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16618599
59GATA1_22025678_ChIP-Seq_K562_Human1.16366168
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14766089
61ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14721181
62TCF4_22108803_ChIP-Seq_LS180_Human1.13326459
63BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.12693693
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12380729
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.10970290
66NANOG_20526341_ChIP-Seq_ESCs_Human1.09386117
67CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.08988369
68HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08951392
69ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08845509
70P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08025438
71TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07968563
72GATA1_19941826_ChIP-Seq_K562_Human1.06463318
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.06310464
74AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06209341
75IRF8_21731497_ChIP-ChIP_J774_Mouse1.05854723
76FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04420369
77GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.03617272
78ATF3_27146783_Chip-Seq_COLON_Human1.02736433
79PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02097492
80CREB1_26743006_Chip-Seq_LNCaP_Human1.00862869
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00112751
82NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99891441
83STAT1_20625510_ChIP-Seq_HELA_Human0.99462514
84ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98632202
85VDR_24787735_ChIP-Seq_THP-1_Human0.98601425
86AR_20517297_ChIP-Seq_VCAP_Human0.98440159
87AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97574498
88BCAT_22108803_ChIP-Seq_LS180_Human0.97375284
89POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96993085
90CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96903371
91GATA2_21666600_ChIP-Seq_HMVEC_Human0.96522168
92NCOR_22424771_ChIP-Seq_293T_Human0.96030333
93Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.95925291
94PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.95048268
95HNFA_21074721_ChIP-Seq_CACO-2_Human0.94835607
96PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94543443
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94500329
98PRDM14_20953172_ChIP-Seq_ESCs_Human0.94041880
99ETV1_20927104_ChIP-Seq_GIST48_Human0.93740969
100SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92995428
101FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92611578
102FOXA1_25329375_ChIP-Seq_VCAP_Human0.92611578
103FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92194973
104CJUN_26792858_Chip-Seq_BT549_Human0.90902950
105FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89571967
106JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89086654
107IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88402409
108P53_21459846_ChIP-Seq_SAOS-2_Human0.87668902
109RBPJ_21746931_ChIP-Seq_IB4_Human0.86004261
110PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85632926
111EGR1_19032775_ChIP-ChIP_M12_Human0.85123910
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84978201
113ETV2_25802403_ChIP-Seq_MESCs_Mouse0.84885888
114TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84882413
115AHR_22903824_ChIP-Seq_MCF-7_Human0.83754439
116GATA1_26923725_Chip-Seq_HPCs_Mouse0.83646069
117* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.83470766
118P300_27058665_Chip-Seq_ZR-75-30cells_Human0.82671245
119NFYA_21822215_ChIP-Seq_K562_Human0.81002221
120CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.80814383
121ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.80253469
122LXR_22292898_ChIP-Seq_THP-1_Human0.79618866
123STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.79468339
124TP53_16413492_ChIP-PET_HCT116_Human0.79083274
125VDR_22108803_ChIP-Seq_LS180_Human0.78731283
126KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78312527
127GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.77861543
128PHF8_20622853_ChIP-Seq_HELA_Human0.77769577
129TAF2_19829295_ChIP-Seq_ESCs_Human0.77727738
130SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.77482549
131SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.77482549
132MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.77245198
133SOX9_24532713_ChIP-Seq_HFSC_Mouse0.77097823
134SMAD3_21741376_ChIP-Seq_HESCs_Human0.76312914
135FOXA1_25552417_ChIP-Seq_VCAP_Human0.76023046
136FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.75686160
137* TP63_23658742_ChIP-Seq_EP156T_Human0.74252057
138JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73910457
139GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73216222
140* CTCF_27219007_Chip-Seq_Bcells_Human0.72731781
141GATA3_24758297_ChIP-Seq_MCF-7_Human0.71970618
142CTNNB1_20460455_ChIP-Seq_HCT116_Human0.71584723
143DROSHA_22980978_ChIP-Seq_HELA_Human0.71569646
144CDX2_22108803_ChIP-Seq_LS180_Human0.71225969
145RARG_19884340_ChIP-ChIP_MEFs_Mouse0.70898053
146PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.70700532
147NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.69735733
148PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.66924071

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.97093033
2MP0001666_abnormal_nutrient_absorption5.54657161
3MP0009840_abnormal_foam_cell4.41964369
4MP0002139_abnormal_hepatobiliary_system4.32761578
5MP0010234_abnormal_vibrissa_follicle3.54189365
6MP0005085_abnormal_gallbladder_physiolo3.48146986
7MP0003252_abnormal_bile_duct3.32625733
8MP0003183_abnormal_peptide_metabolism3.27852152
9MP0010329_abnormal_lipoprotein_level3.18253554
10MP0008875_abnormal_xenobiotic_pharmacok3.16922366
11MP0004264_abnormal_extraembryonic_tissu2.84384000
12MP0003866_abnormal_defecation2.76789955
13MP0000462_abnormal_digestive_system2.68546408
14MP0005365_abnormal_bile_salt2.38331872
15MP0004147_increased_porphyrin_level2.30682529
16MP0003878_abnormal_ear_physiology2.29696269
17MP0005377_hearing/vestibular/ear_phenot2.29696269
18MP0005409_darkened_coat_color2.12870184
19MP0003705_abnormal_hypodermis_morpholog2.11172236
20MP0004019_abnormal_vitamin_homeostasis2.10472600
21MP0003191_abnormal_cellular_cholesterol2.10364246
22MP0003300_gastrointestinal_ulcer1.91135657
23MP0002254_reproductive_system_inflammat1.86797790
24MP0004043_abnormal_pH_regulation1.80275636
25MP0001188_hyperpigmentation1.77875845
26MP0001663_abnormal_digestive_system1.74897179
27MP0002822_catalepsy1.73432350
28MP0005381_digestive/alimentary_phenotyp1.70968053
29MP0005670_abnormal_white_adipose1.59949001
30MP0010155_abnormal_intestine_physiology1.58725466
31MP0000678_abnormal_parathyroid_gland1.57137458
32MP0005167_abnormal_blood-brain_barrier1.51919373
33MP0006054_spinal_hemorrhage1.48229806
34MP0001664_abnormal_digestion1.46499561
35MP0009379_abnormal_foot_pigmentation1.45068126
36MP0001501_abnormal_sleep_pattern1.44357482
37MP0000537_abnormal_urethra_morphology1.41406945
38MP0009780_abnormal_chondrocyte_physiolo1.38808286
39MP0001873_stomach_inflammation1.38437342
40MP0005084_abnormal_gallbladder_morpholo1.37414887
41MP0002138_abnormal_hepatobiliary_system1.36636922
42MP0000609_abnormal_liver_physiology1.36560327
43MP0002876_abnormal_thyroid_physiology1.34907439
44MP0000538_abnormal_urinary_bladder1.33958248
45MP0002118_abnormal_lipid_homeostasis1.33009876
46MP0009697_abnormal_copulation1.32226169
47MP0000477_abnormal_intestine_morphology1.30381304
48MP0005448_abnormal_energy_balance1.26291660
49MP0010352_gastrointestinal_tract_polyps1.25987182
50MP0003806_abnormal_nucleotide_metabolis1.22911387
51MP0005332_abnormal_amino_acid1.19492942
52MP0005174_abnormal_tail_pigmentation1.18866523
53MP0009643_abnormal_urine_homeostasis1.18160005
54MP0004782_abnormal_surfactant_physiolog1.14675416
55MP0009384_cardiac_valve_regurgitation1.08408428
56MP0003724_increased_susceptibility_to1.05991392
57MP0000465_gastrointestinal_hemorrhage1.04356159
58MP0003315_abnormal_perineum_morphology1.02638612
59MP0002796_impaired_skin_barrier0.97950865
60MP0001485_abnormal_pinna_reflex0.97027011
61MP0000015_abnormal_ear_pigmentation0.96267049
62MP0002089_abnormal_postnatal_growth/wei0.94709513
63MP0000490_abnormal_crypts_of0.93951601
64MP0003879_abnormal_hair_cell0.93391402
65MP0005319_abnormal_enzyme/_coenzyme0.88274043
66MP0003045_fibrosis0.87526889
67MP0000467_abnormal_esophagus_morphology0.84626959
68MP0004947_skin_inflammation0.84449715
69MP0005535_abnormal_body_temperature0.83716489
70MP0001845_abnormal_inflammatory_respons0.82933381
71MP0002166_altered_tumor_susceptibility0.79245582
72MP0001849_ear_inflammation0.76155031
73MP0005501_abnormal_skin_physiology0.73859727
74MP0009785_altered_susceptibility_to0.72447417
75MP0009115_abnormal_fat_cell0.71097654
76MP0005166_decreased_susceptibility_to0.70448113
77MP0005636_abnormal_mineral_homeostasis0.68621001
78MP0002136_abnormal_kidney_physiology0.68123034
79MP0001765_abnormal_ion_homeostasis0.67741999
80MP0002277_abnormal_respiratory_mucosa0.67097428
81MP0004858_abnormal_nervous_system0.65887348
82MP0010678_abnormal_skin_adnexa0.65739191
83MP0006138_congestive_heart_failure0.65716921
84MP0000604_amyloidosis0.65514175
85MP0005266_abnormal_metabolism0.65254959
86MP0005584_abnormal_enzyme/coenzyme_acti0.64975209
87MP0006082_CNS_inflammation0.64796988
88MP0002971_abnormal_brown_adipose0.62132726
89MP0009642_abnormal_blood_homeostasis0.61896236
90MP0008872_abnormal_physiological_respon0.61873572
91MP0004484_altered_response_of0.61029874
92MP0000566_synostosis0.60851688
93MP0003868_abnormal_feces_composition0.60347322
94MP0001764_abnormal_homeostasis0.57880578
95MP0008469_abnormal_protein_level0.57552407
96MP0005334_abnormal_fat_pad0.57063840
97MP0000383_abnormal_hair_follicle0.56687616
98MP0005666_abnormal_adipose_tissue0.56186333
99MP0000230_abnormal_systemic_arterial0.56108307
100MP0003283_abnormal_digestive_organ0.55609443
101MP0005451_abnormal_body_composition0.54823219
102MP0005025_abnormal_response_to0.54700046
103MP0002098_abnormal_vibrissa_morphology0.53545294
104MP0003303_peritoneal_inflammation0.53511901
105MP0005310_abnormal_salivary_gland0.53216429
106MP0003453_abnormal_keratinocyte_physiol0.52865748
107MP0008995_early_reproductive_senescence0.52629555
108MP0003718_maternal_effect0.52543886
109MP0005387_immune_system_phenotype0.52464239
110MP0001790_abnormal_immune_system0.52464239
111MP0005376_homeostasis/metabolism_phenot0.52135200
112MP0004270_analgesia0.51019516
113MP0000249_abnormal_blood_vessel0.50908008
114MP0003690_abnormal_glial_cell0.50812276
115MP0002148_abnormal_hypersensitivity_rea0.50542417
116MP0001727_abnormal_embryo_implantation0.50425642
117MP0002006_tumorigenesis0.49334231
118MP0005395_other_phenotype0.48600797
119MP0005367_renal/urinary_system_phenotyp0.48439233
120MP0000516_abnormal_urinary_system0.48439233
121MP0009053_abnormal_anal_canal0.46721721
122MP0001835_abnormal_antigen_presentation0.45819635
123MP0002009_preneoplasia0.45401878
124MP0001756_abnormal_urination0.45019427
125MP0009765_abnormal_xenobiotic_induced0.44655199
126MP0001216_abnormal_epidermal_layer0.44209623
127MP0002896_abnormal_bone_mineralization0.44065851
128MP0002078_abnormal_glucose_homeostasis0.44038119
129MP0005464_abnormal_platelet_physiology0.42943554
130MP0000598_abnormal_liver_morphology0.42413893
131MP0001881_abnormal_mammary_gland0.41601774
132MP0003638_abnormal_response/metabolism_0.41088755
133MP0000427_abnormal_hair_cycle0.40438308
134MP0009764_decreased_sensitivity_to0.40166375
135MP0003953_abnormal_hormone_level0.39289260

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)7.30800612
2Abnormality of glutamine family amino acid metabolism (HP:0010902)6.36325598
3Hypobetalipoproteinemia (HP:0003563)6.26923836
4Acanthocytosis (HP:0001927)6.06455756
5Decreased circulating renin level (HP:0003351)5.70445945
6Autoimmune thrombocytopenia (HP:0001973)5.13115529
7Malnutrition (HP:0004395)5.10768567
8Hydroxyprolinuria (HP:0003080)4.91123530
9Abnormality of proline metabolism (HP:0010907)4.91123530
10Abnormality of renin-angiotensin system (HP:0000847)4.61840483
11Conjugated hyperbilirubinemia (HP:0002908)4.43892609
12Hypolipoproteinemia (HP:0010981)4.42435373
13Right ventricular cardiomyopathy (HP:0011663)4.40196083
14Cupped ribs (HP:0000887)4.20698857
15Confusion (HP:0001289)4.16563722
16Mesangial abnormality (HP:0001966)4.10939793
17Alkalosis (HP:0001948)4.01644798
18Autoimmune hemolytic anemia (HP:0001890)3.96657307
19Pigmentary retinal degeneration (HP:0001146)3.95165264
20Congenital sensorineural hearing impairment (HP:0008527)3.94223822
21Abdominal distention (HP:0003270)3.77016451
22Xanthomatosis (HP:0000991)3.67584517
23Fat malabsorption (HP:0002630)3.64896186
24Poikilocytosis (HP:0004447)3.56745319
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.56328295
26Chronic diarrhea (HP:0002028)3.51240709
27Male infertility (HP:0003251)3.43941826
28Hyperglycinuria (HP:0003108)3.23343652
29Intrahepatic cholestasis (HP:0001406)3.12444200
30Abnormality of monocarboxylic acid metabolism (HP:0010996)3.11155677
31Proximal tubulopathy (HP:0000114)3.07385128
32Widely patent fontanelles and sutures (HP:0004492)3.04013921
33Hyperaldosteronism (HP:0000859)2.99962288
34Rectal prolapse (HP:0002035)2.96238042
35Gastrointestinal dysmotility (HP:0002579)2.94618840
36Abnormal glucose tolerance (HP:0001952)2.84087731
37Hypercholesterolemia (HP:0003124)2.82239000
38Increased IgE level (HP:0003212)2.81700275
39Abnormality of urine glucose concentration (HP:0011016)2.77573786
40Glycosuria (HP:0003076)2.77573786
41Facial shape deformation (HP:0011334)2.77234367
42Potter facies (HP:0002009)2.77234367
43Hypoalphalipoproteinemia (HP:0003233)2.70810393
44Flat acetabular roof (HP:0003180)2.65641343
45Epidermoid cyst (HP:0200040)2.63593495
46Hypokalemia (HP:0002900)2.61656505
47Posterior subcapsular cataract (HP:0007787)2.60460916
48Abnormality of aspartate family amino acid metabolism (HP:0010899)2.58076688
49Mildly elevated creatine phosphokinase (HP:0008180)2.54790649
50Dynein arm defect of respiratory motile cilia (HP:0012255)2.53139340
51Absent/shortened dynein arms (HP:0200106)2.53139340
52Enlarged epiphyses (HP:0010580)2.53089321
53Abnormality of sulfur amino acid metabolism (HP:0004339)2.51393330
54Steatorrhea (HP:0002570)2.48752081
55Dehydration (HP:0001944)2.48346858
56Polycythemia (HP:0001901)2.48341023
57Nephrolithiasis (HP:0000787)2.46278920
58Abnormality of potassium homeostasis (HP:0011042)2.43724297
59Megaloblastic anemia (HP:0001889)2.41642068
60Reticulocytosis (HP:0001923)2.40899653
61Nausea (HP:0002018)2.34388112
62Eczematoid dermatitis (HP:0000976)2.31973057
63Abnormality of the costochondral junction (HP:0000919)2.30671760
64Dicarboxylic aciduria (HP:0003215)2.30394135
65Abnormality of dicarboxylic acid metabolism (HP:0010995)2.30394135
66Increased purine levels (HP:0004368)2.29592384
67Hyperuricemia (HP:0002149)2.29592384
68Pili torti (HP:0003777)2.28999502
69Abnormality of purine metabolism (HP:0004352)2.26924630
70Hyperammonemia (HP:0001987)2.26741710
71Palpitations (HP:0001962)2.26268216
72Abnormality of glycine metabolism (HP:0010895)2.26103239
73Abnormality of serine family amino acid metabolism (HP:0010894)2.26103239
74Severe combined immunodeficiency (HP:0004430)2.23685177
75Hemorrhage of the eye (HP:0011885)2.22211178
76Hypotension (HP:0002615)2.21833019
77Peripheral demyelination (HP:0011096)2.21491062
78Hyperactive renin-angiotensin system (HP:0000841)2.19618293
79Abnormality of B cell number (HP:0010975)2.17650202
80B lymphocytopenia (HP:0010976)2.17650202
81Facial diplegia (HP:0001349)2.16783524
82Combined immunodeficiency (HP:0005387)2.16727141
83Abnormal ciliary motility (HP:0012262)2.16278041
84Hypophosphatemia (HP:0002148)2.14495498
85Abnormal respiratory epithelium morphology (HP:0012253)2.13750014
86Abnormal respiratory motile cilium morphology (HP:0005938)2.13750014
87Increased mean platelet volume (HP:0011877)2.13653682
88Abnormality of the vitamin B12 metabolism (HP:0004341)2.13114443
89Hypoglycemic coma (HP:0001325)2.11008661
90Hyperparathyroidism (HP:0000843)2.09270393
91Metabolic acidosis (HP:0001942)2.08389585
92Abnormality of chloride homeostasis (HP:0011422)2.07784428
93Hyperkalemia (HP:0002153)2.07739652
94Myopathic facies (HP:0002058)2.07703637
95Gonadal dysgenesis (HP:0000133)2.06179262
96Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.05945613
97Thin bony cortex (HP:0002753)2.04723282
98Abnormal respiratory motile cilium physiology (HP:0012261)2.04509161
99Nephritis (HP:0000123)2.03808004
100Abnormal biliary tract morphology (HP:0012440)2.03302547
101Cerebral palsy (HP:0100021)2.03212734
102Chronic bronchitis (HP:0004469)2.00829322
103Systemic lupus erythematosus (HP:0002725)2.00651451
104Abnormality of vitamin B metabolism (HP:0004340)1.98895855
105Progressive sensorineural hearing impairment (HP:0000408)1.98871455
106Abnormal hair laboratory examination (HP:0003328)1.97519431
107Hyperventilation (HP:0002883)1.97494345
108Abnormality of magnesium homeostasis (HP:0004921)1.95926613
109Pancreatitis (HP:0001733)1.95663037
110Abnormality of vitamin metabolism (HP:0100508)1.95353714
111Late onset (HP:0003584)1.95239567
112Abnormality of the gastric mucosa (HP:0004295)1.94762917
113Bone cyst (HP:0012062)1.94301953
114Symptomatic seizures (HP:0011145)1.94114909
115Thyroiditis (HP:0100646)1.93356846
116Alopecia of scalp (HP:0002293)1.92401179
117Hypoalbuminemia (HP:0003073)1.90537965
118Abnormal albumin level (HP:0012116)1.90537965
119Abnormal urine phosphate concentration (HP:0012599)1.90443272
120Woolly hair (HP:0002224)1.90297489
121Abnormality of carpal bone ossification (HP:0006257)1.89959369
122Cholecystitis (HP:0001082)1.89244550
123Abnormal gallbladder physiology (HP:0012438)1.89244550
124Hyperphosphaturia (HP:0003109)1.89096558
125Bronchiectasis (HP:0002110)1.88130153
126Renal tubular acidosis (HP:0001947)1.87297555
127Hyponatremia (HP:0002902)1.87086116
128Abnormality of the nasal mucosa (HP:0000433)1.86246192
129Focal segmental glomerulosclerosis (HP:0000097)1.85914451
130Delayed epiphyseal ossification (HP:0002663)1.84850855
131Biliary tract neoplasm (HP:0100574)1.84813654
132Abnormality of nucleobase metabolism (HP:0010932)1.84611544
133Abnormal tarsal ossification (HP:0008369)1.84357699
134Villous atrophy (HP:0011473)1.81443801
135Abnormality of small intestinal villus morphology (HP:0011472)1.81443801
136Hyperbilirubinemia (HP:0002904)1.80563149
137Azoospermia (HP:0000027)1.80388103
138Nonimmune hydrops fetalis (HP:0001790)1.80312487
139Syncope (HP:0001279)1.80243537
140Metabolic alkalosis (HP:0200114)1.80137029
141Hyperphosphatemia (HP:0002905)1.80095211
142Protuberant abdomen (HP:0001538)1.79844439
143Abnormal platelet volume (HP:0011876)1.79789286
144Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.78997677
145Skin nodule (HP:0200036)1.78946427
146Wide cranial sutures (HP:0010537)1.77991602
147Goiter (HP:0000853)1.77026132
148Axonal loss (HP:0003447)1.76550765
149Complement deficiency (HP:0004431)1.76481218
150Pustule (HP:0200039)1.76023673
151Milia (HP:0001056)1.75140382

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.46341347
2LMTK25.40995800
3MST44.33309165
4MST1R3.87120458
5RIPK12.95893998
6PRKG22.91656270
7MAP2K22.79430143
8PTK62.57993887
9EPHB22.56401393
10MAP3K22.32982108
11STK392.31877905
12GRK62.18351662
13ERN12.14260653
14OXSR12.11050960
15MAP3K102.01605358
16MYLK1.99185152
17EPHA31.87152618
18NME11.66033389
19EPHB11.63826695
20TNIK1.55554993
21DDR21.53985406
22TESK11.52580959
23AKT31.52012855
24PIK3CA1.49062586
25NUAK11.47273286
26MATK1.44823471
27BLK1.41652093
28EPHA21.41581895
29MET1.33352327
30STK241.30105901
31TYRO31.26454562
32LATS11.26405577
33GRK11.22704818
34KSR21.18784478
35MAP3K121.11243492
36EPHA41.10865729
37MAP2K11.05540477
38NLK1.05054486
39ADRBK21.03901289
40RIPK41.01524408
41ICK1.00986994
42FER0.99442489
43PTK20.99241239
44STK100.98264158
45PRKAA20.97639864
46PDK20.96360767
47FGFR30.91037163
48ERBB20.90871304
49TAOK30.89380781
50TRIB30.87107519
51ACVR1B0.86513025
52CASK0.85184636
53INSRR0.84856480
54BMPR1B0.83588231
55MAPK150.83517499
56IRAK10.82837174
57PDGFRA0.82048536
58MAP4K10.81675586
59PAK40.80442537
60CSK0.76081876
61TESK20.76012177
62CDK90.74592916
63SCYL20.74563505
64MAP3K70.72544484
65DMPK0.72508991
66CDK190.70806917
67TAOK10.68905257
68BMX0.68137943
69PDPK10.67927471
70TBK10.64388949
71CAMK1D0.64096590
72CDK120.63319591
73LIMK10.60608093
74MAP3K10.60368014
75MAPK110.60319099
76TEC0.58690646
77MAP3K80.58608120
78CDK60.58446125
79BRSK20.58003019
80BCR0.57818556
81CDC42BPA0.56482772
82TYK20.55824088
83PAK20.54881386
84TGFBR10.54192470
85MAP3K30.53813023
86MELK0.53537037
87MAP2K60.52780491
88FGFR40.51911613
89PRKCZ0.49350083
90PRKAA10.48559512
91MAP4K20.47146675
92PKN20.46575056
93IKBKE0.45434831
94CAMK2D0.45242527
95TXK0.44693027
96RET0.44493118
97STK30.43664770
98DYRK1B0.43618249
99PDK10.43544633
100PRKCI0.43542014
101PDK40.42880487
102PDK30.42880487
103PTK2B0.41964402
104DAPK20.41862885
105GSK3A0.40508495
106PRKCQ0.40393610
107NEK60.40374198
108ADRBK10.40056771
109KDR0.39912462
110TTK0.39248988
111PIK3CG0.39176832
112EEF2K0.38515279
113MAPKAPK30.37665420
114PIM10.37435486
115ROCK10.37034023
116BMPR20.36916378
117TGFBR20.35629273
118CAMK1G0.34612439
119PRKCE0.33480771
120JAK10.33235297
121PRKACG0.33067245
122ITK0.32994615
123PDGFRB0.32975892
124MUSK0.32919331
125KIT0.31993769
126SRC0.30973245
127MAPK70.30351609
128WNK40.29703050
129IGF1R0.29376878
130PAK30.28993698
131PRKCD0.28277013
132PRKCA0.28177372
133MAPKAPK20.28082732
134LRRK20.27740151
135SYK0.27066508
136PRKACA0.26700478
137CSF1R0.26489758
138LYN0.26242582
139FGR0.26104294
140PINK10.25829757
141CAMK2A0.25509394
142YES10.24738615
143STK38L0.24525374
144JAK20.24229014
145WNK30.22908650
146FYN0.21982220

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049755.47159583
2Mineral absorption_Homo sapiens_hsa049783.90269465
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.87690189
4Vitamin digestion and absorption_Homo sapiens_hsa049773.64207678
5Renin-angiotensin system_Homo sapiens_hsa046143.47215490
6Sulfur metabolism_Homo sapiens_hsa009202.79963543
7Caffeine metabolism_Homo sapiens_hsa002322.79409638
8Carbohydrate digestion and absorption_Homo sapiens_hsa049732.42992995
9Starch and sucrose metabolism_Homo sapiens_hsa005002.38527083
10Bile secretion_Homo sapiens_hsa049762.33555471
11Galactose metabolism_Homo sapiens_hsa000522.18598964
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.14590919
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.11273639
14Protein digestion and absorption_Homo sapiens_hsa049742.05064230
15PPAR signaling pathway_Homo sapiens_hsa033201.91821408
16Histidine metabolism_Homo sapiens_hsa003401.82361336
17Nitrogen metabolism_Homo sapiens_hsa009101.73475673
18Fatty acid degradation_Homo sapiens_hsa000711.67148178
19Folate biosynthesis_Homo sapiens_hsa007901.63344344
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.58933093
21Tryptophan metabolism_Homo sapiens_hsa003801.53748330
22Glycerolipid metabolism_Homo sapiens_hsa005611.51110383
23Arginine biosynthesis_Homo sapiens_hsa002201.42722569
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.41960733
25Fructose and mannose metabolism_Homo sapiens_hsa000511.40852370
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.40725740
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.29893253
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.27751346
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.24191964
30ABC transporters_Homo sapiens_hsa020101.20368568
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.18925957
32Asthma_Homo sapiens_hsa053101.17026917
33Glutathione metabolism_Homo sapiens_hsa004801.13698615
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.04358236
35Chemical carcinogenesis_Homo sapiens_hsa052041.01277991
36Pyruvate metabolism_Homo sapiens_hsa006201.00001206
37Fatty acid metabolism_Homo sapiens_hsa012120.98133972
38Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98065718
39Sphingolipid metabolism_Homo sapiens_hsa006000.91509363
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89137448
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87564769
42Cyanoamino acid metabolism_Homo sapiens_hsa004600.86248699
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86114946
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84369285
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83392360
46Fatty acid biosynthesis_Homo sapiens_hsa000610.82915310
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81547624
48Allograft rejection_Homo sapiens_hsa053300.80234084
49beta-Alanine metabolism_Homo sapiens_hsa004100.80071098
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79315130
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.79224640
52Arginine and proline metabolism_Homo sapiens_hsa003300.79011391
53Graft-versus-host disease_Homo sapiens_hsa053320.75206875
54Glycerophospholipid metabolism_Homo sapiens_hsa005640.74663728
55Butanoate metabolism_Homo sapiens_hsa006500.74478554
56Autoimmune thyroid disease_Homo sapiens_hsa053200.73897546
57Retinol metabolism_Homo sapiens_hsa008300.71919281
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.71807862
59Thyroid hormone synthesis_Homo sapiens_hsa049180.67768143
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67546352
61Carbon metabolism_Homo sapiens_hsa012000.63062191
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.60857111
63Linoleic acid metabolism_Homo sapiens_hsa005910.59788829
64Type I diabetes mellitus_Homo sapiens_hsa049400.58439225
65Tyrosine metabolism_Homo sapiens_hsa003500.58389948
66Peroxisome_Homo sapiens_hsa041460.57945695
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53626058
68Tight junction_Homo sapiens_hsa045300.53612551
69Type II diabetes mellitus_Homo sapiens_hsa049300.52440227
70Pancreatic secretion_Homo sapiens_hsa049720.52309149
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48675315
72Pentose phosphate pathway_Homo sapiens_hsa000300.48123215
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48014715
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47632348
75Propanoate metabolism_Homo sapiens_hsa006400.45016323
76Complement and coagulation cascades_Homo sapiens_hsa046100.44091703
77Sulfur relay system_Homo sapiens_hsa041220.43544392
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42511067
79Arachidonic acid metabolism_Homo sapiens_hsa005900.41838592
80Ovarian steroidogenesis_Homo sapiens_hsa049130.41495399
81Lysine degradation_Homo sapiens_hsa003100.40770371
82Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.38973709
83Staphylococcus aureus infection_Homo sapiens_hsa051500.33633945
84Phenylalanine metabolism_Homo sapiens_hsa003600.32362176
85Selenocompound metabolism_Homo sapiens_hsa004500.30904749
86Adherens junction_Homo sapiens_hsa045200.28213790
87Insulin resistance_Homo sapiens_hsa049310.28212041
88Gastric acid secretion_Homo sapiens_hsa049710.28093204
89Renin secretion_Homo sapiens_hsa049240.26405155
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.24941333
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.24130366
92Salmonella infection_Homo sapiens_hsa051320.22203381
93GnRH signaling pathway_Homo sapiens_hsa049120.22159045
94Hepatitis C_Homo sapiens_hsa051600.22144178
95African trypanosomiasis_Homo sapiens_hsa051430.21907515
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.21811875
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.21778340
98Serotonergic synapse_Homo sapiens_hsa047260.21564838
99Ether lipid metabolism_Homo sapiens_hsa005650.21246941
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.20279417
101Antigen processing and presentation_Homo sapiens_hsa046120.20182841
102Other glycan degradation_Homo sapiens_hsa005110.20030324
103Insulin secretion_Homo sapiens_hsa049110.19215196
104Biosynthesis of amino acids_Homo sapiens_hsa012300.18895842
105Metabolic pathways_Homo sapiens_hsa011000.18886755
106Thyroid cancer_Homo sapiens_hsa052160.18718335
107Amoebiasis_Homo sapiens_hsa051460.17681495
108Dorso-ventral axis formation_Homo sapiens_hsa043200.16231771
109Cocaine addiction_Homo sapiens_hsa050300.14428285
110Fatty acid elongation_Homo sapiens_hsa000620.14054020
111Steroid biosynthesis_Homo sapiens_hsa001000.13734871
112Salivary secretion_Homo sapiens_hsa049700.13007233
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.11671883
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.11572351
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.10080290
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.09776429
117Bladder cancer_Homo sapiens_hsa052190.09436536
118Leishmaniasis_Homo sapiens_hsa051400.07347082
119Pertussis_Homo sapiens_hsa051330.06780814
120Hematopoietic cell lineage_Homo sapiens_hsa046400.06604766
121Amphetamine addiction_Homo sapiens_hsa050310.05287018
122Glucagon signaling pathway_Homo sapiens_hsa049220.04015273
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.03253757
124Taste transduction_Homo sapiens_hsa047420.01931923

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