CHRAC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CHRAC1 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.22753753
2ribosomal small subunit assembly (GO:0000028)5.77243006
3DNA unwinding involved in DNA replication (GO:0006268)4.40924135
4ribosome assembly (GO:0042255)4.33691342
5establishment of integrated proviral latency (GO:0075713)4.20219609
6viral transcription (GO:0019083)4.19216750
7deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.08212162
8translational termination (GO:0006415)4.05109461
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.97939281
10folic acid-containing compound biosynthetic process (GO:0009396)3.96170639
11cotranslational protein targeting to membrane (GO:0006613)3.86385900
12ribosomal small subunit biogenesis (GO:0042274)3.86274740
13protein targeting to ER (GO:0045047)3.83817413
14maturation of SSU-rRNA (GO:0030490)3.81335316
15DNA replication checkpoint (GO:0000076)3.74582240
16proteasome assembly (GO:0043248)3.69026077
17protein localization to endoplasmic reticulum (GO:0070972)3.68911674
18translational elongation (GO:0006414)3.68105315
19response to interferon-beta (GO:0035456)3.64120512
20establishment of protein localization to endoplasmic reticulum (GO:0072599)3.61116788
21telomere maintenance via semi-conservative replication (GO:0032201)3.47621015
22IMP biosynthetic process (GO:0006188)3.33574239
23regulation of translational termination (GO:0006449)3.30646579
24purine nucleobase biosynthetic process (GO:0009113)3.29339213
25ribosome biogenesis (GO:0042254)3.26833145
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.26533044
27telomere maintenance via recombination (GO:0000722)3.26290633
28establishment of viral latency (GO:0019043)3.26029383
29ribosomal large subunit biogenesis (GO:0042273)3.22837239
30signal peptide processing (GO:0006465)3.21004443
31viral life cycle (GO:0019058)3.17005782
32antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.15801486
33negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.14683051
34cellular protein complex disassembly (GO:0043624)3.12558445
35DNA catabolic process, exonucleolytic (GO:0000738)3.09991715
36translation (GO:0006412)3.09797914
37pteridine-containing compound biosynthetic process (GO:0042559)3.09492722
38translational initiation (GO:0006413)3.09338420
39DNA replication initiation (GO:0006270)3.08759398
40DNA strand elongation involved in DNA replication (GO:0006271)3.08510918
41metallo-sulfur cluster assembly (GO:0031163)3.06644659
42iron-sulfur cluster assembly (GO:0016226)3.06644659
43cellular response to interferon-beta (GO:0035458)3.05781834
44nucleobase biosynthetic process (GO:0046112)3.03731282
45platelet dense granule organization (GO:0060155)3.03349845
46sequestering of actin monomers (GO:0042989)3.02355761
47IMP metabolic process (GO:0046040)3.01919885
48nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.01415548
49DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.01295759
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.00181199
51DNA strand elongation (GO:0022616)2.99952804
52intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.98289909
53signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.98289909
54signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.97910852
55signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.97910852
56signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.97910852
57mitotic chromosome condensation (GO:0007076)2.96695719
58termination of RNA polymerase III transcription (GO:0006386)2.95617657
59transcription elongation from RNA polymerase III promoter (GO:0006385)2.95617657
60oxidative phosphorylation (GO:0006119)2.95448044
61respiratory chain complex IV assembly (GO:0008535)2.93999329
62mitotic metaphase plate congression (GO:0007080)2.92239996
63protein complex biogenesis (GO:0070271)2.88941426
64regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.88760685
65somatic hypermutation of immunoglobulin genes (GO:0016446)2.87099213
66somatic diversification of immune receptors via somatic mutation (GO:0002566)2.87099213
67maturation of 5.8S rRNA (GO:0000460)2.86832362
68negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.86745487
69negative regulation of ligase activity (GO:0051352)2.86745487
70mitotic sister chromatid cohesion (GO:0007064)2.85731220
71mitotic sister chromatid segregation (GO:0000070)2.85630060
72pseudouridine synthesis (GO:0001522)2.85072188
73positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.83829926
74mitotic recombination (GO:0006312)2.83655351
75somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.83598899
76somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.83598899
77isotype switching (GO:0045190)2.83598899
78cytochrome complex assembly (GO:0017004)2.83268277
79regulation of cellular amino acid metabolic process (GO:0006521)2.83265012
80exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.82827959
81CENP-A containing nucleosome assembly (GO:0034080)2.82810969
82formation of translation preinitiation complex (GO:0001731)2.82547769
83ribonucleoprotein complex biogenesis (GO:0022613)2.81975157
84signal transduction involved in DNA damage checkpoint (GO:0072422)2.81936819
85signal transduction involved in DNA integrity checkpoint (GO:0072401)2.81936819
86regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.80771381
87positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.80739500
88nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.80394282
89rRNA modification (GO:0000154)2.80167947
90transcription from mitochondrial promoter (GO:0006390)2.79616772
91mitochondrial RNA metabolic process (GO:0000959)2.79006587
92mitotic nuclear envelope disassembly (GO:0007077)2.78389861
93G1/S transition of mitotic cell cycle (GO:0000082)2.78231257
94cell cycle G1/S phase transition (GO:0044843)2.78231257
95signal transduction involved in cell cycle checkpoint (GO:0072395)2.77811139
96rRNA methylation (GO:0031167)2.75898293
97chromatin remodeling at centromere (GO:0031055)2.75383704
98mitochondrial respiratory chain complex I assembly (GO:0032981)2.75169909
99NADH dehydrogenase complex assembly (GO:0010257)2.75169909
100mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.75169909
101sister chromatid segregation (GO:0000819)2.74360349
102positive regulation of chromosome segregation (GO:0051984)2.73702134
103positive regulation of ligase activity (GO:0051351)2.73488072
104DNA topological change (GO:0006265)2.72454021
105protein localization to kinetochore (GO:0034501)2.71872359
106protein complex disassembly (GO:0043241)2.71685027
107DNA ligation (GO:0006266)2.69130041
108deoxyribonucleotide biosynthetic process (GO:0009263)2.69074583
1097-methylguanosine mRNA capping (GO:0006370)2.68955545
110transcription-coupled nucleotide-excision repair (GO:0006283)2.68293497
111protein K6-linked ubiquitination (GO:0085020)2.67995289
112daunorubicin metabolic process (GO:0044597)2.67784376
113polyketide metabolic process (GO:0030638)2.67784376
114doxorubicin metabolic process (GO:0044598)2.67784376
115protein localization to chromosome, centromeric region (GO:0071459)2.67216961
116rRNA processing (GO:0006364)2.65719522
117mitochondrial respiratory chain complex assembly (GO:0033108)2.65702576
1187-methylguanosine RNA capping (GO:0009452)2.65468830
119RNA capping (GO:0036260)2.65468830
120anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.63599690
121antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.63096887
122telomere maintenance via telomere lengthening (GO:0010833)2.62904604
123protein targeting to mitochondrion (GO:0006626)2.62533047
124kinetochore organization (GO:0051383)2.61960587
125cellular component biogenesis (GO:0044085)2.61392859
126deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.61194241
127regulation of ubiquitin-protein transferase activity (GO:0051438)2.60648391
128DNA double-strand break processing (GO:0000729)2.59992058
129macromolecular complex disassembly (GO:0032984)2.59005508
130base-excision repair (GO:0006284)2.58330547
131spliceosomal snRNP assembly (GO:0000387)2.57947414
132histone exchange (GO:0043486)2.57356682
133rRNA metabolic process (GO:0016072)2.57168708
134DNA replication-independent nucleosome assembly (GO:0006336)2.56737574
135DNA replication-independent nucleosome organization (GO:0034724)2.56737574
136tetrahydrofolate metabolic process (GO:0046653)2.56155499
137regulation of ligase activity (GO:0051340)2.55420126
138NIK/NF-kappaB signaling (GO:0038061)2.55137477
139nucleotide-excision repair, DNA gap filling (GO:0006297)2.54735056
140heterochromatin organization (GO:0070828)2.54718792
141positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.53147314
142positive regulation of mitotic sister chromatid separation (GO:1901970)2.53147314
143cellular response to zinc ion (GO:0071294)2.50988052
144regulation of necroptotic process (GO:0060544)2.50538857
145nuclear-transcribed mRNA catabolic process (GO:0000956)2.50338493
146L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.49628469
147viral mRNA export from host cell nucleus (GO:0046784)2.49133028
148regulation of mitochondrial translation (GO:0070129)2.48093979
149tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.47424667
150RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.47424667
151peptidyl-histidine modification (GO:0018202)2.47253005
152heart contraction (GO:0060047)2.46062626
153heart process (GO:0003015)2.46062626
154pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.44647852
155deoxyribonucleotide catabolic process (GO:0009264)2.43849082

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.44450699
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.57887153
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.47821206
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.31658217
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.31568581
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.29835398
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.21819392
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.20542661
9IRF8_22096565_ChIP-ChIP_GC-B_Human3.03884214
10ELF1_17652178_ChIP-ChIP_JURKAT_Human3.03227965
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.88845113
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.79569599
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.69465399
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.69039682
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.63000195
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.56973475
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.54752288
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.46819782
19FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.43184632
20VDR_23849224_ChIP-Seq_CD4+_Human2.42831935
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.40879078
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.36647011
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.33013015
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.25933269
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.20738641
26MYC_19030024_ChIP-ChIP_MESCs_Mouse2.19547901
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.11581688
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.10214002
29* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.09925402
30IRF8_21731497_ChIP-ChIP_J774_Mouse2.09052362
31FOXP3_21729870_ChIP-Seq_TREG_Human2.07127800
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.06255714
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.96964744
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.96049406
35* DCP1A_22483619_ChIP-Seq_HELA_Human1.95975625
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.94899667
37XRN2_22483619_ChIP-Seq_HELA_Human1.94036322
38* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89923352
39* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.85925507
40ELK1_19687146_ChIP-ChIP_HELA_Human1.84425229
41* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.83317556
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.82854807
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.75574038
44GABP_19822575_ChIP-Seq_HepG2_Human1.74841575
45CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.72387963
46* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.70341441
47SPI1_23547873_ChIP-Seq_NB4_Human1.69951621
48STAT4_19710469_ChIP-ChIP_TH1__Mouse1.69073866
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.68413329
50RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.67898997
51AR_21909140_ChIP-Seq_LNCAP_Human1.63437906
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60114971
53MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.59177471
54* TTF2_22483619_ChIP-Seq_HELA_Human1.58801873
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57952846
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.56779956
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.51911605
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48736772
59EGR1_19374776_ChIP-ChIP_THP-1_Human1.43664199
60* MYC_22102868_ChIP-Seq_BL_Human1.43498325
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.43377174
62SCL_19346495_ChIP-Seq_HPC-7_Human1.39217453
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38276558
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34101716
65KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.33052091
66MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32401653
67* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.30599725
68* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28804091
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28680939
70* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25774025
71BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.22552365
72CIITA_25753668_ChIP-Seq_RAJI_Human1.20839460
73MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19332422
74MYB_21317192_ChIP-Seq_ERMYB_Mouse1.15049097
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14241481
76LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12922753
77MYCN_18555785_ChIP-Seq_MESCs_Mouse1.12163628
78* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10372155
79MYB_26560356_Chip-Seq_TH2_Human1.09859646
80POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08270854
81E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07113070
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06783641
83ELK1_22589737_ChIP-Seq_MCF10A_Human1.04552626
84* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04062460
85ZNF263_19887448_ChIP-Seq_K562_Human1.03175638
86GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02938672
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02457862
88MYC_18940864_ChIP-ChIP_HL60_Human1.01744800
89GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99607212
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98238837
91* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96636232
92* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95891302
93FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.95715419
94TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95453944
95NANOG_18555785_ChIP-Seq_MESCs_Mouse0.94964551
96RUNX1_22412390_ChIP-Seq_EML_Mouse0.94954973
97* E2F1_21310950_ChIP-Seq_MCF-7_Human0.94554855
98CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93178563
99* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92961366
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92887861
101MYB_26560356_Chip-Seq_TH1_Human0.91901374
102GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91865613
103* KDM5A_27292631_Chip-Seq_BREAST_Human0.89119168
104SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89029492
105CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89014513
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88772202
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88153115
108* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87577192
109IRF8_27001747_Chip-Seq_BMDM_Mouse0.86785036
110* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86174265
111CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.85840014
112TBX5_21415370_ChIP-Seq_HL-1_Mouse0.84083501
113TFEB_21752829_ChIP-Seq_HELA_Human0.83363877
114E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82795098
115SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.82488059
116VDR_21846776_ChIP-Seq_THP-1_Human0.82173525
117ELF5_23300383_ChIP-Seq_T47D_Human0.81735056
118EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.81189467
119NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.79996544
120FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.78895004
121POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.78473443
122* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.72450327
123SOX17_20123909_ChIP-Seq_XEN_Mouse0.71684060

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.75216779
2MP0003693_abnormal_embryo_hatching2.84462151
3MP0009785_altered_susceptibility_to2.78662655
4MP0003763_abnormal_thymus_physiology2.77317989
5MP0005671_abnormal_response_to2.63846644
6MP0000685_abnormal_immune_system2.61268115
7MP0002148_abnormal_hypersensitivity_rea2.50055085
8MP0008058_abnormal_DNA_repair2.41399287
9MP0008007_abnormal_cellular_replicative2.25569412
10MP0003724_increased_susceptibility_to2.19571000
11MP0002396_abnormal_hematopoietic_system2.19328543
12MP0005025_abnormal_response_to2.13813909
13MP0008057_abnormal_DNA_replication2.06747429
14MP0001853_heart_inflammation2.05309845
15MP0010094_abnormal_chromosome_stability2.04300827
16MP0003186_abnormal_redox_activity1.98176550
17MP0003077_abnormal_cell_cycle1.97984036
18MP0004957_abnormal_blastocyst_morpholog1.97042156
19MP0009333_abnormal_splenocyte_physiolog1.95486706
20MP0001800_abnormal_humoral_immune1.94621157
21MP0005000_abnormal_immune_tolerance1.92362275
22MP0002132_abnormal_respiratory_system1.91141096
23MP0002877_abnormal_melanocyte_morpholog1.87598190
24MP0002452_abnormal_antigen_presenting1.87270763
25MP0002006_tumorigenesis1.84266507
26MP0002420_abnormal_adaptive_immunity1.84076818
27MP0002723_abnormal_immune_serum1.83866960
28MP0001819_abnormal_immune_cell1.82995607
29MP0002166_altered_tumor_susceptibility1.82739741
30MP0005410_abnormal_fertilization1.77524595
31MP0002398_abnormal_bone_marrow1.77405087
32MP0009379_abnormal_foot_pigmentation1.73086246
33MP0003436_decreased_susceptibility_to1.71942816
34MP0001790_abnormal_immune_system1.70214403
35MP0005387_immune_system_phenotype1.70214403
36MP0002419_abnormal_innate_immunity1.69551577
37MP0000350_abnormal_cell_proliferation1.67171241
38MP0010307_abnormal_tumor_latency1.66650125
39MP0001730_embryonic_growth_arrest1.64643747
40MP0006082_CNS_inflammation1.63413652
41MP0010352_gastrointestinal_tract_polyps1.62261796
42MP0000490_abnormal_crypts_of1.60930505
43MP0003786_premature_aging1.59788821
44MP0000716_abnormal_immune_system1.58825800
45MP0000689_abnormal_spleen_morphology1.57560601
46MP0002405_respiratory_system_inflammati1.54911889
47MP0005075_abnormal_melanosome_morpholog1.54745677
48MP0004808_abnormal_hematopoietic_stem1.51585604
49MP0009697_abnormal_copulation1.49327244
50MP0000372_irregular_coat_pigmentation1.48086363
51MP0001873_stomach_inflammation1.47593938
52MP0002722_abnormal_immune_system1.47406824
53MP0002429_abnormal_blood_cell1.46482486
54MP0001764_abnormal_homeostasis1.46444064
55MP0005397_hematopoietic_system_phenotyp1.39039195
56MP0001545_abnormal_hematopoietic_system1.39039195
57MP0006035_abnormal_mitochondrial_morpho1.36568028
58MP0005451_abnormal_body_composition1.34615735
59MP0001986_abnormal_taste_sensitivity1.34311163
60MP0010155_abnormal_intestine_physiology1.34132453
61MP0001697_abnormal_embryo_size1.33678699
62MP0005464_abnormal_platelet_physiology1.30183782
63MP0005174_abnormal_tail_pigmentation1.28160641
64MP0006036_abnormal_mitochondrial_physio1.26324725
65MP0009278_abnormal_bone_marrow1.20447962
66MP0001845_abnormal_inflammatory_respons1.20107139
67MP0003111_abnormal_nucleus_morphology1.19098555
68MP0003866_abnormal_defecation1.17045422
69MP0000703_abnormal_thymus_morphology1.16851114
70MP0002163_abnormal_gland_morphology1.16620069
71MP0002080_prenatal_lethality1.13704029
72MP0002095_abnormal_skin_pigmentation1.13044605
73MP0005380_embryogenesis_phenotype1.12748282
74MP0001672_abnormal_embryogenesis/_devel1.12748282
75MP0008469_abnormal_protein_level1.10017018
76MP0008877_abnormal_DNA_methylation1.08534891
77MP0003656_abnormal_erythrocyte_physiolo1.07941444
78MP0000858_altered_metastatic_potential1.07924879
79MP0001661_extended_life_span1.07814984
80MP0006292_abnormal_olfactory_placode1.06625750
81MP0002019_abnormal_tumor_incidence1.06353825
82MP0005310_abnormal_salivary_gland1.05979552
83MP0003984_embryonic_growth_retardation1.05460603
84MP0003943_abnormal_hepatobiliary_system1.04874115
85MP0003646_muscle_fatigue1.04056392
86MP0002933_joint_inflammation1.02974718
87MP0002088_abnormal_embryonic_growth/wei1.01205264
88MP0000749_muscle_degeneration1.00304762
89MP0008932_abnormal_embryonic_tissue1.00175037
90MP0004510_myositis0.99761052
91MP0000313_abnormal_cell_death0.99721551
92MP0000358_abnormal_cell_content/0.97142348
93MP0005084_abnormal_gallbladder_morpholo0.96120575
94MP0000015_abnormal_ear_pigmentation0.95047811
95MP0003828_pulmonary_edema0.94986152
96MP0001929_abnormal_gametogenesis0.94550502
97MP0005501_abnormal_skin_physiology0.94193964
98MP0000343_altered_response_to0.91630234
99MP0001881_abnormal_mammary_gland0.90616266
100MP0002210_abnormal_sex_determination0.89188080
101MP0003806_abnormal_nucleotide_metabolis0.87511963
102MP0000465_gastrointestinal_hemorrhage0.86893922
103MP0002086_abnormal_extraembryonic_tissu0.85467863
104MP0002009_preneoplasia0.84961596
105MP0004782_abnormal_surfactant_physiolog0.84547062
106MP0003941_abnormal_skin_development0.84525646
107MP0003950_abnormal_plasma_membrane0.83579878
108MP0004233_abnormal_muscle_weight0.82383725
109MP0008995_early_reproductive_senescence0.81351257
110MP0001533_abnormal_skeleton_physiology0.80636488
111MP0001216_abnormal_epidermal_layer0.78483362
112MP0005266_abnormal_metabolism0.78329050
113MP0005083_abnormal_biliary_tract0.76205036
114MP0001727_abnormal_embryo_implantation0.74739217
115MP0003718_maternal_effect0.74240526
116MP0006054_spinal_hemorrhage0.74067271
117MP0002160_abnormal_reproductive_system0.73818121
118MP0004185_abnormal_adipocyte_glucose0.73382217
119MP0002938_white_spotting0.73253901
120MP0001191_abnormal_skin_condition0.72057703
121MP0002796_impaired_skin_barrier0.71990340
122MP0004197_abnormal_fetal_growth/weight/0.71797531
123MP0005330_cardiomyopathy0.71529452
124MP0001145_abnormal_male_reproductive0.69982843
125MP0000613_abnormal_salivary_gland0.69906245
126MP0001119_abnormal_female_reproductive0.69445223
127MP0005384_cellular_phenotype0.67633573
128MP0005379_endocrine/exocrine_gland_phen0.67522236
129MP0002085_abnormal_embryonic_tissue0.66136867
130MP0005621_abnormal_cell_physiology0.66051167
131MP0004147_increased_porphyrin_level0.65922557
132MP0000681_abnormal_thyroid_gland0.65874052
133MP0000598_abnormal_liver_morphology0.65846856
134MP0008961_abnormal_basal_metabolism0.65602723
135MP0002970_abnormal_white_adipose0.65432117
136MP0002102_abnormal_ear_morphology0.64118417
137MP0000627_abnormal_mammary_gland0.62495528
138MP0005389_reproductive_system_phenotype0.62103014
139MP0005076_abnormal_cell_differentiation0.60279371
140MP0003448_altered_tumor_morphology0.58386619
141MP0000653_abnormal_sex_gland0.58209028

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)3.78779282
2Abnormal number of erythroid precursors (HP:0012131)3.74900013
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.50979118
4Mitochondrial inheritance (HP:0001427)3.49280379
5Hepatocellular necrosis (HP:0001404)3.47867753
6Chromsome breakage (HP:0040012)3.47476130
7Hepatic necrosis (HP:0002605)3.44582812
8Acute necrotizing encephalopathy (HP:0006965)3.41777148
9Type I transferrin isoform profile (HP:0003642)3.38683973
10Reticulocytopenia (HP:0001896)3.37575092
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.29866383
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.29866383
13Type 2 muscle fiber atrophy (HP:0003554)3.19091538
14Increased CSF lactate (HP:0002490)3.17259078
15Abnormal mitochondria in muscle tissue (HP:0008316)3.16169319
16Increased hepatocellular lipid droplets (HP:0006565)3.14257472
17Reduced antithrombin III activity (HP:0001976)3.11008366
18Aplastic anemia (HP:0001915)3.09599093
19Exertional dyspnea (HP:0002875)3.06664073
20Thrombocytosis (HP:0001894)3.05708173
21Muscle fiber atrophy (HP:0100295)2.97004936
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.94722241
23Abnormality of the preputium (HP:0100587)2.92846245
24Lipid accumulation in hepatocytes (HP:0006561)2.91166542
253-Methylglutaconic aciduria (HP:0003535)2.90356246
26Recurrent abscess formation (HP:0002722)2.81267433
27Elevated erythrocyte sedimentation rate (HP:0003565)2.78450101
28IgM deficiency (HP:0002850)2.77524720
29Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.71225039
30Abnormal glycosylation (HP:0012345)2.69311064
31Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.69311064
32Abnormal protein N-linked glycosylation (HP:0012347)2.69311064
33Abnormal protein glycosylation (HP:0012346)2.69311064
34Acute encephalopathy (HP:0006846)2.67853578
35Myositis (HP:0100614)2.67829812
36Renal Fanconi syndrome (HP:0001994)2.64035256
37Increased serum lactate (HP:0002151)2.63847801
38Abnormality of T cell physiology (HP:0011840)2.61600822
39Stomatitis (HP:0010280)2.55902473
40Progressive macrocephaly (HP:0004481)2.55118571
41Meckel diverticulum (HP:0002245)2.50732651
42Abnormality of chromosome stability (HP:0003220)2.48431312
43Aplasia/Hypoplasia of the sacrum (HP:0008517)2.47330619
44Increased intramyocellular lipid droplets (HP:0012240)2.45865640
45Petechiae (HP:0000967)2.45144909
46Respiratory difficulties (HP:0002880)2.43586235
47Exercise intolerance (HP:0003546)2.43390072
48Cerebral edema (HP:0002181)2.42995569
49Generalized aminoaciduria (HP:0002909)2.40402948
50Recurrent bronchitis (HP:0002837)2.38157689
51Poor head control (HP:0002421)2.37665904
52Abnormality of the ileum (HP:0001549)2.37039414
53Abnormality of glycolysis (HP:0004366)2.37025742
54B lymphocytopenia (HP:0010976)2.34312666
55IgG deficiency (HP:0004315)2.31855251
56Pallor (HP:0000980)2.31699849
57Progressive muscle weakness (HP:0003323)2.31516699
5811 pairs of ribs (HP:0000878)2.30863855
59Abnormality of methionine metabolism (HP:0010901)2.30714608
60Pancreatic islet-cell hyperplasia (HP:0004510)2.30656139
61Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.29948889
62Abnormality of alanine metabolism (HP:0010916)2.29948889
63Hyperalaninemia (HP:0003348)2.29948889
64True hermaphroditism (HP:0010459)2.29703371
65Recurrent bacterial skin infections (HP:0005406)2.29547500
66Macrocytic anemia (HP:0001972)2.28754535
67Increased serum pyruvate (HP:0003542)2.28132975
68Increased IgM level (HP:0003496)2.26104126
69Increased muscle lipid content (HP:0009058)2.24937444
70Cutaneous melanoma (HP:0012056)2.23767347
71Lactic acidosis (HP:0003128)2.20446816
72Absent thumb (HP:0009777)2.20416721
73Hypergonadotropic hypogonadism (HP:0000815)2.19712711
74Pancreatic fibrosis (HP:0100732)2.18941863
75Aplasia/Hypoplasia of the uvula (HP:0010293)2.18694909
76Abnormality of B cell number (HP:0010975)2.17605834
77Microvesicular hepatic steatosis (HP:0001414)2.17493334
78Dry hair (HP:0011359)2.16796571
79Abnormality of T cells (HP:0002843)2.16177338
80Degeneration of anterior horn cells (HP:0002398)2.10981553
81Abnormality of the anterior horn cell (HP:0006802)2.10981553
82Recurrent cutaneous fungal infections (HP:0011370)2.10825517
83Chronic mucocutaneous candidiasis (HP:0002728)2.10825517
84Abnormal delayed hypersensitivity skin test (HP:0002963)2.10006141
85Abnormal spermatogenesis (HP:0008669)2.08400732
86Rhabdomyosarcoma (HP:0002859)2.06890499
87Aplasia/Hypoplasia of the thymus (HP:0010515)2.06867789
88Prominent metopic ridge (HP:0005487)2.05985665
89Poikiloderma (HP:0001029)2.05142275
90Testicular atrophy (HP:0000029)2.05097531
91Premature ovarian failure (HP:0008209)2.04740483
92Small intestinal stenosis (HP:0012848)2.03545567
93Duodenal stenosis (HP:0100867)2.03545567
94Ependymoma (HP:0002888)2.03364261
95Squamous cell carcinoma (HP:0002860)2.03350384
96Abnormality of homocysteine metabolism (HP:0010919)2.03053237
97Homocystinuria (HP:0002156)2.03053237
98Multiple enchondromatosis (HP:0005701)2.01821679
99Premature graying of hair (HP:0002216)2.00765862
100Respiratory failure (HP:0002878)2.00059324
101Abnormality of lateral ventricle (HP:0030047)1.98864239
102Combined immunodeficiency (HP:0005387)1.98247055
103Oral leukoplakia (HP:0002745)1.97123453
104Nausea (HP:0002018)1.95392956
105Pancytopenia (HP:0001876)1.94668170
106Trismus (HP:0000211)1.93749129
107Sensory axonal neuropathy (HP:0003390)1.93428721
108Absent rod-and cone-mediated responses on ERG (HP:0007688)1.92456125
109Optic neuritis (HP:0100653)1.91264119
110Retrobulbar optic neuritis (HP:0100654)1.91264119
111Microretrognathia (HP:0000308)1.89482494
112Hypoglycemic seizures (HP:0002173)1.89468999
113Birth length less than 3rd percentile (HP:0003561)1.88851487
114Pancreatic cysts (HP:0001737)1.88801087
115Lymphoma (HP:0002665)1.88480292
116Abnormality of renal resorption (HP:0011038)1.87345854
117Methylmalonic acidemia (HP:0002912)1.86831610
118Bronchitis (HP:0012387)1.86684684
119Recurrent fungal infections (HP:0002841)1.85273888
120Recurrent skin infections (HP:0001581)1.84705461
121Colon cancer (HP:0003003)1.83680617
122Recurrent viral infections (HP:0004429)1.83470804
123Abnormality of cells of the lymphoid lineage (HP:0012140)1.83252937
124Lymphopenia (HP:0001888)1.82588733
125Neutropenia (HP:0001875)1.82530476
126Gonadotropin excess (HP:0000837)1.82140011
127Cleft eyelid (HP:0000625)1.80373334
128Prominent nose (HP:0000448)1.79683492
129Hyperinsulinemic hypoglycemia (HP:0000825)1.79305922
130Eczematoid dermatitis (HP:0000976)1.78956490
131Constricted visual fields (HP:0001133)1.78930650
132Palpitations (HP:0001962)1.78904725
133Severe combined immunodeficiency (HP:0004430)1.77622218
134Nephroblastoma (Wilms tumor) (HP:0002667)1.76948742
135Panhypogammaglobulinemia (HP:0003139)1.76477729
136Myelodysplasia (HP:0002863)1.75114445
137Mediastinal lymphadenopathy (HP:0100721)1.75021411
138Meningitis (HP:0001287)1.74663607
139Orchitis (HP:0100796)1.74321297
140Orthostatic hypotension (HP:0001278)1.74032046
141Hypothermia (HP:0002045)1.73422267
142Secondary amenorrhea (HP:0000869)1.73204034
143Microglossia (HP:0000171)1.72963066
144Dynein arm defect of respiratory motile cilia (HP:0012255)1.71718805
145Absent/shortened dynein arms (HP:0200106)1.71718805
146Rough bone trabeculation (HP:0100670)1.71708589
147Bone marrow hypocellularity (HP:0005528)1.71512084
148Glioma (HP:0009733)1.71213965
149Autoimmune hemolytic anemia (HP:0001890)1.70066821
150Hypoglycemic coma (HP:0001325)1.69795696
151Optic nerve coloboma (HP:0000588)1.69003563
152Sparse eyelashes (HP:0000653)1.68741842

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.96063636
2NME23.13132152
3STK163.11401081
4PIM22.42063320
5EIF2AK12.35026825
6IKBKE2.20444486
7NEK12.20266831
8MAP4K12.17374403
9BUB12.15970445
10EIF2AK32.09937494
11TXK2.07357892
12KIT2.04620299
13TSSK62.04339278
14VRK12.00811552
15SCYL21.98545367
16TTK1.92572467
17TEC1.89588123
18ZAK1.88299160
19MUSK1.83048141
20ACVR1B1.82456896
21STK101.82269753
22WEE11.77774147
23TLK11.71069388
24IRAK41.67651867
25TYK21.64477687
26TESK11.64363350
27MYLK1.64231738
28PLK31.61954650
29KDR1.57992972
30TBK11.56815284
31PLK41.55671473
32TRIM281.52222929
33MAP3K141.51687579
34ZAP701.44602967
35PBK1.43704402
36CDK81.41635733
37IKBKB1.36359360
38JAK31.35970266
39SRPK11.31068303
40TIE11.28570605
41TAF11.27801063
42DYRK31.26262030
43RPS6KA41.25514966
44PASK1.23041335
45BRSK21.21131125
46ADRBK21.15994787
47MAP3K31.14999989
48STK31.14672521
49BTK1.13636099
50OBSCN1.13408504
51IRAK31.12603388
52MAP4K21.11773705
53MKNK11.11750455
54BLK1.11465041
55BRSK11.10988781
56EIF2AK21.07693326
57TGFBR11.06624475
58PAK41.06321423
59FLT31.06009267
60NLK1.04194266
61MAP2K31.03104021
62CHEK21.02166460
63MST41.00429298
64MAP3K120.99555629
65ILK0.99219240
66TGFBR20.96590320
67MAPKAPK30.93440377
68PIM10.92222204
69RPS6KB20.90854851
70CLK10.90719308
71CDC70.89595512
72NUAK10.89046358
73NEK90.87796795
74ATR0.87635637
75MAP3K80.87020600
76STK38L0.83450713
77CDK40.81789232
78RPS6KA50.81186074
79TESK20.79749216
80CSF1R0.78583873
81BRAF0.78529737
82MST1R0.77189513
83SYK0.77165192
84SIK30.74945925
85YES10.74556101
86PDK30.74409211
87PDK40.74409211
88DAPK10.73733128
89TAOK20.73672217
90AURKB0.73599411
91LYN0.73413331
92PDK20.73265922
93CHEK10.73047569
94STK240.72557340
95SMG10.69697984
96GRK70.69377728
97CDK70.68411568
98BMPR1B0.68171294
99NEK60.68119366
100TRPM70.67397373
101BCKDK0.67272930
102MAP2K60.67099738
103STK40.66446716
104CHUK0.66094980
105PLK10.64845031
106NME10.64319568
107ARAF0.62579897
108CDK190.62471265
109AURKA0.62061720
110CSNK2A10.61551497
111MKNK20.59239655
112NEK20.58831534
113BMPR20.58547272
114CDK120.58253570
115EPHA20.57177379
116ERN10.55522513
117MAP3K110.54545753
118CDK90.54360857
119ATM0.54156007
120PIK3CA0.51411054
121LCK0.51302683
122MAPK150.51199109
123GRK10.50350772
124CCNB10.50330817
125CSNK2A20.50203627
126ERBB30.50045570
127FRK0.49076055
128PRKG20.48272338
129TAOK30.48197372
130MAPKAPK50.48095893
131LIMK10.47209235
132TNIK0.45311721
133MAPK110.43489657
134MAPKAPK20.42101301
135PRKCI0.40955251
136ALK0.40919417
137LRRK20.35766395
138CDK60.34124162
139IRAK10.33986008
140PAK10.31864113
141CSNK1G10.31473065
142CDK20.31120153
143CDK10.29623043
144CSNK1G30.27989289
145SIK10.25530586
146ABL20.25288334

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.26548265
2Proteasome_Homo sapiens_hsa030503.60201038
3DNA replication_Homo sapiens_hsa030303.51453927
4RNA polymerase_Homo sapiens_hsa030202.93074417
5Mismatch repair_Homo sapiens_hsa034302.88612946
6Protein export_Homo sapiens_hsa030602.58732012
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.56030542
8Homologous recombination_Homo sapiens_hsa034402.46777466
9Pyrimidine metabolism_Homo sapiens_hsa002402.43575572
10Base excision repair_Homo sapiens_hsa034102.38383816
11Nucleotide excision repair_Homo sapiens_hsa034202.09171052
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.04458721
13Spliceosome_Homo sapiens_hsa030402.04172350
14Parkinsons disease_Homo sapiens_hsa050122.00126030
15Oxidative phosphorylation_Homo sapiens_hsa001901.97831128
16Basal transcription factors_Homo sapiens_hsa030221.83707737
17RNA degradation_Homo sapiens_hsa030181.62590443
18Non-homologous end-joining_Homo sapiens_hsa034501.61594701
19Primary immunodeficiency_Homo sapiens_hsa053401.61590689
20Huntingtons disease_Homo sapiens_hsa050161.59847712
21Fanconi anemia pathway_Homo sapiens_hsa034601.58820802
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.50619340
23Purine metabolism_Homo sapiens_hsa002301.44722423
24Allograft rejection_Homo sapiens_hsa053301.38138742
25Herpes simplex infection_Homo sapiens_hsa051681.36599985
26RNA transport_Homo sapiens_hsa030131.36245698
27Antigen processing and presentation_Homo sapiens_hsa046121.34358216
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.29592920
29Measles_Homo sapiens_hsa051621.27237307
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.26090594
31Cell cycle_Homo sapiens_hsa041101.24608747
32Graft-versus-host disease_Homo sapiens_hsa053321.21139502
33Legionellosis_Homo sapiens_hsa051341.19056351
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.18952439
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.18938381
36Fatty acid elongation_Homo sapiens_hsa000621.18687076
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.16875632
38Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.14754586
39NF-kappa B signaling pathway_Homo sapiens_hsa040641.14188683
40Alzheimers disease_Homo sapiens_hsa050101.13651371
41mRNA surveillance pathway_Homo sapiens_hsa030151.13055147
42Folate biosynthesis_Homo sapiens_hsa007901.09685114
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08438784
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05934182
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05683340
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.02915570
47Biosynthesis of amino acids_Homo sapiens_hsa012300.99624240
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.99322742
49One carbon pool by folate_Homo sapiens_hsa006700.95703574
50Leishmaniasis_Homo sapiens_hsa051400.95152505
51Arachidonic acid metabolism_Homo sapiens_hsa005900.95091347
52Hematopoietic cell lineage_Homo sapiens_hsa046400.93885574
53Sulfur relay system_Homo sapiens_hsa041220.92167555
54Other glycan degradation_Homo sapiens_hsa005110.91538433
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91170545
56Carbon metabolism_Homo sapiens_hsa012000.89600134
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86575768
58Epstein-Barr virus infection_Homo sapiens_hsa051690.86504863
59p53 signaling pathway_Homo sapiens_hsa041150.81349370
60N-Glycan biosynthesis_Homo sapiens_hsa005100.78219619
61Asthma_Homo sapiens_hsa053100.77765553
62Autoimmune thyroid disease_Homo sapiens_hsa053200.77619043
63Propanoate metabolism_Homo sapiens_hsa006400.75132626
64Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75113100
65Pentose phosphate pathway_Homo sapiens_hsa000300.73102945
66Sulfur metabolism_Homo sapiens_hsa009200.72719287
67Influenza A_Homo sapiens_hsa051640.71890385
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71837192
69Fructose and mannose metabolism_Homo sapiens_hsa000510.71522149
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71221686
71Thyroid cancer_Homo sapiens_hsa052160.69136481
72Glutathione metabolism_Homo sapiens_hsa004800.68284435
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68140573
74Malaria_Homo sapiens_hsa051440.68086455
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67576725
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.66651484
77Galactose metabolism_Homo sapiens_hsa000520.65788958
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.64577028
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64040869
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.61901593
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61759927
82Pertussis_Homo sapiens_hsa051330.59625658
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59094806
84Systemic lupus erythematosus_Homo sapiens_hsa053220.58094591
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57767835
86Apoptosis_Homo sapiens_hsa042100.57145062
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53107612
88Metabolic pathways_Homo sapiens_hsa011000.49835048
89Shigellosis_Homo sapiens_hsa051310.47111750
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46468258
91Hepatitis B_Homo sapiens_hsa051610.45778634
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45536404
93Type I diabetes mellitus_Homo sapiens_hsa049400.43490406
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43477314
95Selenocompound metabolism_Homo sapiens_hsa004500.42647567
96Rheumatoid arthritis_Homo sapiens_hsa053230.42465653
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42169392
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42126456
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40708901
100HTLV-I infection_Homo sapiens_hsa051660.38102680
101Oocyte meiosis_Homo sapiens_hsa041140.37545418
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36940520
103Vitamin B6 metabolism_Homo sapiens_hsa007500.35819050
104Linoleic acid metabolism_Homo sapiens_hsa005910.33807250
105Cardiac muscle contraction_Homo sapiens_hsa042600.33596305
106Peroxisome_Homo sapiens_hsa041460.33193531
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32966806
108Viral myocarditis_Homo sapiens_hsa054160.32020394
109Toxoplasmosis_Homo sapiens_hsa051450.31070084
110Viral carcinogenesis_Homo sapiens_hsa052030.30648425
111B cell receptor signaling pathway_Homo sapiens_hsa046620.29669479
112Osteoclast differentiation_Homo sapiens_hsa043800.29538452
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28535463
114Salmonella infection_Homo sapiens_hsa051320.28416762
115Bladder cancer_Homo sapiens_hsa052190.28267735
116Maturity onset diabetes of the young_Homo sapiens_hsa049500.25546399
117TNF signaling pathway_Homo sapiens_hsa046680.25095210
118Staphylococcus aureus infection_Homo sapiens_hsa051500.24744011
119Caffeine metabolism_Homo sapiens_hsa002320.24503431
120Pyruvate metabolism_Homo sapiens_hsa006200.24318477
121Pancreatic cancer_Homo sapiens_hsa052120.22814833
122Sphingolipid metabolism_Homo sapiens_hsa006000.18596613
123Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.18444142
124Fatty acid metabolism_Homo sapiens_hsa012120.12915330
125Chronic myeloid leukemia_Homo sapiens_hsa052200.12708297
126Regulation of autophagy_Homo sapiens_hsa041400.11661760
127Small cell lung cancer_Homo sapiens_hsa052220.07786780
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.06629479

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