CHRD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. It has been suggested that this gene could be a candidate gene for Cornelia de Lange syndrome. Reduced expression of this gene results in enhanced bone regeneration. Alternative splicing results in multiple transcript variants. Other alternative splice variants have been described but their full length sequence has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ionotropic glutamate receptor signaling pathway (GO:0035235)5.66576516
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.52565949
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.40822556
4regulation of fibrinolysis (GO:0051917)5.34108175
5complement activation, alternative pathway (GO:0006957)5.33569869
6vocalization behavior (GO:0071625)5.30987622
7regulation of protein activation cascade (GO:2000257)5.30963509
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.20936364
9L-phenylalanine catabolic process (GO:0006559)5.20936364
10negative regulation of fibrinolysis (GO:0051918)5.19266808
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.17879792
12glutamate receptor signaling pathway (GO:0007215)5.13926278
13regulation of complement activation (GO:0030449)5.13171310
14locomotory exploration behavior (GO:0035641)5.07320155
15protein carboxylation (GO:0018214)5.07016247
16peptidyl-glutamic acid carboxylation (GO:0017187)5.07016247
17regulation of glutamate receptor signaling pathway (GO:1900449)4.84388824
18triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.81883324
19protein localization to synapse (GO:0035418)4.74814589
20glutamate secretion (GO:0014047)4.70456612
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.70122336
22erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.66363783
23L-phenylalanine metabolic process (GO:0006558)4.66363783
24synaptic vesicle exocytosis (GO:0016079)4.62814740
25neuronal action potential propagation (GO:0019227)4.61636977
26synaptic vesicle maturation (GO:0016188)4.59889115
27synaptic transmission, glutamatergic (GO:0035249)4.57884053
28synaptic vesicle docking involved in exocytosis (GO:0016081)4.54911090
29regulation of neuronal synaptic plasticity (GO:0048168)4.49124120
30regulation of long-term neuronal synaptic plasticity (GO:0048169)4.49118812
31positive regulation of synapse maturation (GO:0090129)4.31000085
32exogenous drug catabolic process (GO:0042738)4.25245231
33exploration behavior (GO:0035640)4.24787850
34regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.24496811
35epoxygenase P450 pathway (GO:0019373)4.23272927
36regulation of plasminogen activation (GO:0010755)4.20327436
37drug catabolic process (GO:0042737)4.08843073
38neuron-neuron synaptic transmission (GO:0007270)4.05288011
39regulation of excitatory postsynaptic membrane potential (GO:0060079)3.99198884
40blood coagulation, intrinsic pathway (GO:0007597)3.99068602
41regulation of synaptic vesicle exocytosis (GO:2000300)3.98672891
42long-term memory (GO:0007616)3.95297876
43plasma lipoprotein particle remodeling (GO:0034369)3.94801662
44protein-lipid complex remodeling (GO:0034368)3.94801662
45macromolecular complex remodeling (GO:0034367)3.94801662
46neuron recognition (GO:0008038)3.94044933
47neuron cell-cell adhesion (GO:0007158)3.93777163
48regulation of dendritic spine morphogenesis (GO:0061001)3.93192578
49dendritic spine morphogenesis (GO:0060997)3.92329486
50omega-hydroxylase P450 pathway (GO:0097267)3.90107222
51neurotransmitter-gated ion channel clustering (GO:0072578)3.89436897
52negative regulation of sterol transport (GO:0032372)3.88706623
53negative regulation of cholesterol transport (GO:0032375)3.88706623
54glutamate metabolic process (GO:0006536)3.85997421
55glyoxylate metabolic process (GO:0046487)3.84440016
56axonal fasciculation (GO:0007413)3.83873928
57regulation of synaptic vesicle transport (GO:1902803)3.81321312
58positive regulation of dendritic spine morphogenesis (GO:0061003)3.80771073
59regulation of postsynaptic membrane potential (GO:0060078)3.75460791
60regulation of synaptic plasticity (GO:0048167)3.75317543
61neurotransmitter secretion (GO:0007269)3.75246885
62high-density lipoprotein particle remodeling (GO:0034375)3.67759187
63cholesterol efflux (GO:0033344)3.67271365
64gamma-aminobutyric acid signaling pathway (GO:0007214)3.65071083
65G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.63527992
66ethanol oxidation (GO:0006069)3.60059872
67dendritic spine organization (GO:0097061)3.58361788
68reverse cholesterol transport (GO:0043691)3.57301789
69synaptic vesicle endocytosis (GO:0048488)3.52270414
70positive regulation of membrane potential (GO:0045838)3.50916855
71regulation of cholesterol esterification (GO:0010872)3.49746832
72fibrinolysis (GO:0042730)3.49389420
73cellular potassium ion homeostasis (GO:0030007)3.48067130
74long-term synaptic potentiation (GO:0060291)3.47492344
75positive regulation of dendritic spine development (GO:0060999)3.46939228
76positive regulation of lipoprotein lipase activity (GO:0051006)3.45135272
77positive regulation of triglyceride lipase activity (GO:0061365)3.45135272
78aromatic amino acid family catabolic process (GO:0009074)3.45022734
79layer formation in cerebral cortex (GO:0021819)3.43607599
80negative regulation of synaptic transmission, GABAergic (GO:0032229)3.43198567
81regulation of synapse structural plasticity (GO:0051823)3.42546275
82protein activation cascade (GO:0072376)3.41822979
83intestinal cholesterol absorption (GO:0030299)3.39470011
84regulation of apoptotic cell clearance (GO:2000425)3.38133304
85gamma-aminobutyric acid transport (GO:0015812)3.34772389
86cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.33891750
87membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.33123189
88regulation of vesicle fusion (GO:0031338)3.32859364
89innervation (GO:0060384)3.31874610
90imidazole-containing compound metabolic process (GO:0052803)3.29672789
91regulation of dendritic spine development (GO:0060998)3.29163882
92proline transport (GO:0015824)3.28880549
93behavioral defense response (GO:0002209)3.28572149
94behavioral fear response (GO:0001662)3.28572149
95transmission of nerve impulse (GO:0019226)3.27966698
96cell communication by electrical coupling (GO:0010644)3.25596833
97acute-phase response (GO:0006953)3.25533300
98complement activation, classical pathway (GO:0006958)3.24884929
99positive regulation of fibroblast migration (GO:0010763)3.24160083
100positive regulation of neurotransmitter secretion (GO:0001956)3.21375690
101triglyceride homeostasis (GO:0070328)3.20082471
102acylglycerol homeostasis (GO:0055090)3.20082471
103regulation of synapse maturation (GO:0090128)3.19614475
104axon ensheathment in central nervous system (GO:0032291)3.18596504
105central nervous system myelination (GO:0022010)3.18596504
106chemosensory behavior (GO:0007635)3.17650579
107presynaptic membrane assembly (GO:0097105)3.16506626
108G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.16268377
109cellular sodium ion homeostasis (GO:0006883)3.13126285
110C4-dicarboxylate transport (GO:0015740)3.13013418
111presynaptic membrane organization (GO:0097090)3.12982132
112membrane depolarization (GO:0051899)3.12662255
113postsynaptic membrane organization (GO:0001941)3.11464650
114very-low-density lipoprotein particle assembly (GO:0034379)3.11192691
115complement activation (GO:0006956)3.10925595
116cerebellar granule cell differentiation (GO:0021707)3.10761135
117gonadal mesoderm development (GO:0007506)3.10202241
118fear response (GO:0042596)3.09617891
119serine family amino acid catabolic process (GO:0009071)3.09175389
120regulation of triglyceride catabolic process (GO:0010896)3.08971471
121regulation of synaptic transmission, glutamatergic (GO:0051966)3.08816422
122low-density lipoprotein particle remodeling (GO:0034374)3.08699155
123negative regulation of protein activation cascade (GO:2000258)3.08515148
124plasma lipoprotein particle organization (GO:0071827)3.08447199
125cerebellar Purkinje cell differentiation (GO:0021702)3.06061402
126negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.03762940
127long term synaptic depression (GO:0060292)3.01472943
128learning (GO:0007612)2.99669352
129protein-lipid complex subunit organization (GO:0071825)2.98665735
130central nervous system projection neuron axonogenesis (GO:0021952)2.97362827
131neurotransmitter transport (GO:0006836)2.97049373
132positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.96954301
133positive regulation of fatty acid biosynthetic process (GO:0045723)2.95190247
134negative regulation of lipase activity (GO:0060192)2.94256156
135phospholipid efflux (GO:0033700)2.94218479
136plasma lipoprotein particle assembly (GO:0034377)2.93866352
137regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.93804769
138opsonization (GO:0008228)2.93691378
139neuromuscular process controlling balance (GO:0050885)2.93376780
140response to histamine (GO:0034776)2.91633978
141regulation of humoral immune response (GO:0002920)2.91454724
142regulation of synaptic transmission (GO:0050804)2.91211330
143regulation of glutamate secretion (GO:0014048)2.91002921
144dendrite morphogenesis (GO:0048813)2.90774264
145membrane depolarization during action potential (GO:0086010)2.89779902
146establishment of nucleus localization (GO:0040023)2.89313783
147urea metabolic process (GO:0019627)2.89178237
148positive regulation of vesicle fusion (GO:0031340)2.88897551
149negative regulation of blood coagulation (GO:0030195)2.88600498
150negative regulation of hemostasis (GO:1900047)2.88600498
151dicarboxylic acid biosynthetic process (GO:0043650)2.87550940
152negative regulation of amino acid transport (GO:0051956)2.87337214
153regulation of neurotransmitter secretion (GO:0046928)2.85802204
154regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.85472877
155ethanol metabolic process (GO:0006067)2.84786102
156neuromuscular process controlling posture (GO:0050884)2.84332321
157regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.82671427
158regulation of neurotransmitter levels (GO:0001505)2.81553308
159activation of protein kinase A activity (GO:0034199)2.81355575
160positive regulation of synaptic transmission (GO:0050806)2.80914493
161sodium ion export (GO:0071436)2.80653640
162cell migration in hindbrain (GO:0021535)2.80517263
163positive regulation of dendrite development (GO:1900006)2.79569062
164plasma lipoprotein particle clearance (GO:0034381)2.78585281
165ephrin receptor signaling pathway (GO:0048013)2.77877888
166protein-lipid complex assembly (GO:0065005)2.77553763
167drug metabolic process (GO:0017144)2.77520286
168regulation of inositol phosphate biosynthetic process (GO:0010919)2.76618461

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.14210627
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.65890424
3GBX2_23144817_ChIP-Seq_PC3_Human3.63526567
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12749268
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.10974626
6JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05520378
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.80684111
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.80684111
9* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.79369642
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.75264697
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.71857291
12* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.67338079
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.54947417
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51894420
15* EED_16625203_ChIP-ChIP_MESCs_Mouse2.51572006
16* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50009146
17DROSHA_22980978_ChIP-Seq_HELA_Human2.48298591
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.46579577
19* REST_21632747_ChIP-Seq_MESCs_Mouse2.45931025
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.45799592
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.26786546
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.24378267
23PPARA_22158963_ChIP-Seq_LIVER_Mouse2.23692705
24* EZH2_27294783_Chip-Seq_ESCs_Mouse2.21057578
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18251528
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.15606050
27LXR_22158963_ChIP-Seq_LIVER_Mouse2.12086035
28* RNF2_27304074_Chip-Seq_ESCs_Mouse2.11133706
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.92514910
30* REST_18959480_ChIP-ChIP_MESCs_Mouse1.92085788
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88529741
32PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.86946741
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.81467451
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.73378415
35FOXA2_19822575_ChIP-Seq_HepG2_Human1.72554696
36* LXR_22292898_ChIP-Seq_THP-1_Human1.72392127
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71688412
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68669199
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64128910
40SMAD4_21799915_ChIP-Seq_A2780_Human1.60501547
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.60024954
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59992726
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.58945006
44EGR1_23403033_ChIP-Seq_LIVER_Mouse1.57918742
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54800881
46AR_21572438_ChIP-Seq_LNCaP_Human1.51457264
47CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.50444090
48SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.49397926
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49245814
50* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49187976
51TRIM28_21343339_ChIP-Seq_HEK293_Human1.44427145
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43569134
53ZNF274_21170338_ChIP-Seq_K562_Hela1.42357031
54* RING1B_27294783_Chip-Seq_ESCs_Mouse1.37308789
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37189921
56P300_19829295_ChIP-Seq_ESCs_Human1.32988352
57TP53_16413492_ChIP-PET_HCT116_Human1.30810797
58RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29833873
59PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.27785442
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.26220275
61SMC4_20622854_ChIP-Seq_HELA_Human1.25366156
62* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25190670
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25062323
64AR_25329375_ChIP-Seq_VCAP_Human1.23019973
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23018026
66* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22453633
67TAF15_26573619_Chip-Seq_HEK293_Human1.22417420
68AR_19668381_ChIP-Seq_PC3_Human1.21381705
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21370078
70* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19654578
71SOX2_21211035_ChIP-Seq_LN229_Gbm1.18339737
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.17959753
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.16073478
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15589563
75WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15077504
76DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14923434
77PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12886465
78TP53_18474530_ChIP-ChIP_U2OS_Human1.12562224
79ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11268701
80RING1B_27294783_Chip-Seq_NPCs_Mouse1.10869183
81ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10859161
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10680580
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09814464
84SMAD_19615063_ChIP-ChIP_OVARY_Human1.09568669
85ESR1_21235772_ChIP-Seq_MCF-7_Human1.09520628
86HNF4A_19822575_ChIP-Seq_HepG2_Human1.09170493
87STAT3_23295773_ChIP-Seq_U87_Human1.08952133
88PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08700820
89* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08078192
90P68_20966046_ChIP-Seq_HELA_Human1.06155837
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.06120954
92CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05669542
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05496462
94SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04723207
95BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04149364
96TET1_21490601_ChIP-Seq_MESCs_Mouse1.03828800
97ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02976610
98TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02594840
99VDR_22108803_ChIP-Seq_LS180_Human1.01923025
100BCAT_22108803_ChIP-Seq_LS180_Human1.01165325
101AHR_22903824_ChIP-Seq_MCF-7_Human1.00108322
102NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99954565
103EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99464635
104ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99100004
105TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.98606425
106KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97805088
107TP53_20018659_ChIP-ChIP_R1E_Mouse0.97606330
108OCT4_19829295_ChIP-Seq_ESCs_Human0.97358301
109SMAD3_21741376_ChIP-Seq_HESCs_Human0.97146400
110* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96726036
111RAD21_21589869_ChIP-Seq_MESCs_Mouse0.96487336
112YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96417488
113FUS_26573619_Chip-Seq_HEK293_Human0.96415702
114* KDM2B_26808549_Chip-Seq_K562_Human0.96278595
115* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95920549
116GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94876647
117ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94635224
118TCF4_23295773_ChIP-Seq_U87_Human0.93643178
119RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93260140
120SMAD4_21741376_ChIP-Seq_HESCs_Human0.93160335
121OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92868858
122UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92232112
123MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92199430
124CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90764735
125KLF4_19829295_ChIP-Seq_ESCs_Human0.89979306
126CTCF_27219007_Chip-Seq_Bcells_Human0.89623071
127ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89535837
128* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89413859
129POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89264954
130TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89264954
131* PRDM14_20953172_ChIP-Seq_ESCs_Human0.88787709
132MYC_19915707_ChIP-ChIP_AK7_Human0.88623513
133EP300_21415370_ChIP-Seq_HL-1_Mouse0.88396797
134RUNX2_22187159_ChIP-Seq_PCA_Human0.88390574
135POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87899235
136CREB1_26743006_Chip-Seq_LNCaP_Human0.87874389
137BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87697494
138MYC_27129775_Chip-Seq_CORNEA_Mouse0.87192656
139CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85313927
140ESR1_20079471_ChIP-ChIP_T-47D_Human0.85302394
141TET1_21451524_ChIP-Seq_MESCs_Mouse0.83626450
142* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.80478338
143CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.79825859
144GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77547106
145CTCF_20526341_ChIP-Seq_ESCs_Human0.75644736
146SA1_27219007_Chip-Seq_Bcells_Human0.75496124
147NFIB_24661679_ChIP-Seq_LUNG_Mouse0.74799104
148CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.73249778
149SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.72964247
150EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.72383640
151TP53_23651856_ChIP-Seq_MEFs_Mouse0.72236923
152STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.71280604

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.33505376
2MP0003880_abnormal_central_pattern5.28191643
3MP0002139_abnormal_hepatobiliary_system4.52232229
4* MP0003635_abnormal_synaptic_transmissio4.22633677
5MP0005360_urolithiasis4.16925939
6MP0004270_analgesia3.45986792
7* MP0002063_abnormal_learning/memory/cond3.35960135
8MP0009745_abnormal_behavioral_response3.33292705
9MP0008875_abnormal_xenobiotic_pharmacok3.27339598
10MP0003195_calcinosis3.16083119
11MP0005365_abnormal_bile_salt3.05784588
12MP0002064_seizures2.99972609
13MP0001968_abnormal_touch/_nociception2.84506911
14MP0001501_abnormal_sleep_pattern2.77427306
15MP0005085_abnormal_gallbladder_physiolo2.73876736
16* MP0002572_abnormal_emotion/affect_behav2.68790195
17MP0002736_abnormal_nociception_after2.59802196
18MP0009046_muscle_twitch2.53117481
19MP0002272_abnormal_nervous_system2.46080550
20MP0010329_abnormal_lipoprotein_level2.39839249
21MP0009780_abnormal_chondrocyte_physiolo2.37475969
22MP0002735_abnormal_chemical_nociception2.26759519
23MP0001440_abnormal_grooming_behavior2.26164084
24MP0001486_abnormal_startle_reflex2.21400210
25MP0002734_abnormal_mechanical_nocicepti2.11724657
26MP0003252_abnormal_bile_duct2.08040962
27MP0003329_amyloid_beta_deposits2.03226521
28MP0005670_abnormal_white_adipose1.87784960
29MP0001666_abnormal_nutrient_absorption1.86764483
30MP0002067_abnormal_sensory_capabilities1.77781154
31MP0005423_abnormal_somatic_nervous1.76771868
32MP0002837_dystrophic_cardiac_calcinosis1.76703328
33MP0000778_abnormal_nervous_system1.76208229
34MP0002184_abnormal_innervation1.75048951
35MP0004858_abnormal_nervous_system1.74887539
36MP0003879_abnormal_hair_cell1.70393847
37MP0002733_abnormal_thermal_nociception1.66180111
38MP0010368_abnormal_lymphatic_system1.61110286
39MP0008569_lethality_at_weaning1.58846814
40MP0000566_synostosis1.58683668
41MP0002557_abnormal_social/conspecific_i1.55661599
42MP0000751_myopathy1.55107392
43MP0001970_abnormal_pain_threshold1.53015153
44MP0004145_abnormal_muscle_electrophysio1.52785673
45MP0006276_abnormal_autonomic_nervous1.50852099
46MP0003283_abnormal_digestive_organ1.49827740
47MP0005409_darkened_coat_color1.47888123
48MP0000955_abnormal_spinal_cord1.45227805
49MP0002822_catalepsy1.44943711
50MP0004811_abnormal_neuron_physiology1.44751998
51MP0004885_abnormal_endolymph1.43253072
52MP0002909_abnormal_adrenal_gland1.37354161
53MP0001502_abnormal_circadian_rhythm1.36803984
54MP0003172_abnormal_lysosome_physiology1.36022849
55MP0005646_abnormal_pituitary_gland1.35832094
56MP0005332_abnormal_amino_acid1.32308493
57MP0000920_abnormal_myelination1.29279823
58* MP0002066_abnormal_motor_capabilities/c1.28739525
59MP0003122_maternal_imprinting1.27434279
60MP0003868_abnormal_feces_composition1.27255998
61MP0004924_abnormal_behavior1.24348223
62MP0005386_behavior/neurological_phenoty1.24348223
63MP0002118_abnormal_lipid_homeostasis1.24252664
64MP0002882_abnormal_neuron_morphology1.23850930
65MP0003633_abnormal_nervous_system1.19523642
66MP0003123_paternal_imprinting1.16397031
67MP0010386_abnormal_urinary_bladder1.15668136
68MP0003787_abnormal_imprinting1.14424998
69MP0003075_altered_response_to1.11183152
70MP0001984_abnormal_olfaction1.06984845
71MP0001986_abnormal_taste_sensitivity1.06605717
72MP0005645_abnormal_hypothalamus_physiol1.05910388
73MP0002089_abnormal_postnatal_growth/wei1.05531798
74MP0003631_nervous_system_phenotype1.04757987
75MP0004510_myositis1.04203375
76MP0000604_amyloidosis0.99527155
77* MP0002152_abnormal_brain_morphology0.98910692
78MP0002138_abnormal_hepatobiliary_system0.96821860
79MP0004484_altered_response_of0.96637231
80MP0005535_abnormal_body_temperature0.96290033
81MP0002069_abnormal_eating/drinking_beha0.94514647
82MP0001177_atelectasis0.91441003
83MP0009840_abnormal_foam_cell0.90433161
84MP0002876_abnormal_thyroid_physiology0.88460113
85MP0001188_hyperpigmentation0.87342167
86MP0003191_abnormal_cellular_cholesterol0.87008205
87MP0004215_abnormal_myocardial_fiber0.85898453
88MP0005623_abnormal_meninges_morphology0.85600660
89MP0001348_abnormal_lacrimal_gland0.84936633
90MP0000013_abnormal_adipose_tissue0.84847578
91* MP0002249_abnormal_larynx_morphology0.83907180
92MP0004142_abnormal_muscle_tone0.83499493
93MP0000639_abnormal_adrenal_gland0.80906321
94MP0008874_decreased_physiological_sensi0.80669106
95MP0001765_abnormal_ion_homeostasis0.80370610
96MP0003632_abnormal_nervous_system0.79073669
97MP0004085_abnormal_heartbeat0.75946834
98MP0000609_abnormal_liver_physiology0.75768639
99MP0008872_abnormal_physiological_respon0.74718992
100MP0002971_abnormal_brown_adipose0.74586883
101MP0001963_abnormal_hearing_physiology0.74528288
102MP0005187_abnormal_penis_morphology0.74188307
103MP0003634_abnormal_glial_cell0.73413860
104MP0008961_abnormal_basal_metabolism0.73367441
105MP0004043_abnormal_pH_regulation0.72305872
106MP0010234_abnormal_vibrissa_follicle0.72106131
107MP0001905_abnormal_dopamine_level0.71985757
108MP0004742_abnormal_vestibular_system0.71503119
109MP0005448_abnormal_energy_balance0.71348517
110MP0005167_abnormal_blood-brain_barrier0.69917030
111MP0004233_abnormal_muscle_weight0.66611275
112MP0001664_abnormal_digestion0.65294804
113MP0000003_abnormal_adipose_tissue0.65143664
114MP0002078_abnormal_glucose_homeostasis0.62290063
115MP0003136_yellow_coat_color0.60885727
116* MP0005595_abnormal_vascular_smooth0.60456102
117MP0001485_abnormal_pinna_reflex0.59020995
118MP0003690_abnormal_glial_cell0.58697481
119MP0002229_neurodegeneration0.58399069
120MP0005499_abnormal_olfactory_system0.58099314
121MP0005394_taste/olfaction_phenotype0.58099314
122MP0000747_muscle_weakness0.56552690
123MP0005551_abnormal_eye_electrophysiolog0.55475949
124MP0004130_abnormal_muscle_cell0.54841414
125* MP0002752_abnormal_somatic_nervous0.54717902
126MP0005620_abnormal_muscle_contractility0.54178543
127MP0005166_decreased_susceptibility_to0.50862005
128MP0005171_absent_coat_pigmentation0.50172692
129MP0003045_fibrosis0.50120235
130* MP0000026_abnormal_inner_ear0.49634525
131* MP0003861_abnormal_nervous_system0.47193587
132MP0010769_abnormal_survival0.46697133
133MP0000631_abnormal_neuroendocrine_gland0.46357879
134MP0000759_abnormal_skeletal_muscle0.45690010
135MP0002638_abnormal_pupillary_reflex0.45289930

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.50130421
2Deep venous thrombosis (HP:0002625)7.89745645
3Complement deficiency (HP:0004431)7.10297447
4Prolonged partial thromboplastin time (HP:0003645)6.35040446
5Abnormality of aromatic amino acid family metabolism (HP:0004338)5.95258847
6Focal seizures (HP:0007359)5.90687121
7Myokymia (HP:0002411)5.78713378
8Joint hemorrhage (HP:0005261)5.48793464
9Abnormality of complement system (HP:0005339)5.33701794
10Abnormality of monocarboxylic acid metabolism (HP:0010996)5.00525160
11Atonic seizures (HP:0010819)4.97668937
12Visual hallucinations (HP:0002367)4.87799590
13Hypobetalipoproteinemia (HP:0003563)4.83026147
14Febrile seizures (HP:0002373)4.60533168
15Epileptic encephalopathy (HP:0200134)4.55750160
16Systemic lupus erythematosus (HP:0002725)4.46405321
17Absence seizures (HP:0002121)4.32521637
18Progressive cerebellar ataxia (HP:0002073)4.11365867
19Dialeptic seizures (HP:0011146)4.10883932
20Abnormality of the lower motor neuron (HP:0002366)4.08186668
21Hyperventilation (HP:0002883)4.03703403
22Glomerulonephritis (HP:0000099)4.02021034
23Hyperlipoproteinemia (HP:0010980)4.01510465
24Generalized tonic-clonic seizures (HP:0002069)3.86186596
25Xanthomatosis (HP:0000991)3.85595009
26Action tremor (HP:0002345)3.65043248
27Broad-based gait (HP:0002136)3.29816428
28Amblyopia (HP:0000646)3.25518431
29Conjugated hyperbilirubinemia (HP:0002908)3.22847359
30Impaired vibration sensation in the lower limbs (HP:0002166)3.18097554
31Cerebral inclusion bodies (HP:0100314)3.14214569
32Dysdiadochokinesis (HP:0002075)3.13976514
33Gaze-evoked nystagmus (HP:0000640)3.08727759
34Supranuclear gaze palsy (HP:0000605)3.06465042
35Poor eye contact (HP:0000817)3.03181257
36Dysmetria (HP:0001310)3.03102947
37Hypercholesterolemia (HP:0003124)2.95244642
38Abnormality of the common coagulation pathway (HP:0010990)2.94014843
39Hypolipoproteinemia (HP:0010981)2.92764618
40Hemorrhage of the eye (HP:0011885)2.90708673
41Hemiparesis (HP:0001269)2.88954354
42Impaired social interactions (HP:0000735)2.88026801
43Abnormal social behavior (HP:0012433)2.88026801
44Drooling (HP:0002307)2.83035263
45Excessive salivation (HP:0003781)2.83035263
46Status epilepticus (HP:0002133)2.82238482
47Truncal ataxia (HP:0002078)2.78502954
48Depression (HP:0000716)2.77786653
49Mitral stenosis (HP:0001718)2.76065698
50Anxiety (HP:0000739)2.64868113
51Hypoalphalipoproteinemia (HP:0003233)2.61847445
52Impaired smooth pursuit (HP:0007772)2.57784591
53Hemiplegia (HP:0002301)2.56429189
54Neurofibrillary tangles (HP:0002185)2.56380819
55Scanning speech (HP:0002168)2.55067910
56Abnormal eating behavior (HP:0100738)2.52473100
57Absent speech (HP:0001344)2.50642099
58Epileptiform EEG discharges (HP:0011182)2.49307086
59Genetic anticipation (HP:0003743)2.46560694
60Nephritis (HP:0000123)2.46238549
61Lymphangioma (HP:0100764)2.44302091
62Bronchomalacia (HP:0002780)2.39795495
63Diplopia (HP:0000651)2.37857478
64Abnormality of binocular vision (HP:0011514)2.37857478
65Postural instability (HP:0002172)2.37725049
66Dysmetric saccades (HP:0000641)2.35309309
67Akinesia (HP:0002304)2.33828521
68Abnormality of the intrinsic pathway (HP:0010989)2.32985238
69Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.31043880
70Delayed CNS myelination (HP:0002188)2.28809300
71Ankle clonus (HP:0011448)2.26252499
72Focal dystonia (HP:0004373)2.24783727
73Torticollis (HP:0000473)2.24314629
74Fetal akinesia sequence (HP:0001989)2.20610714
75Urinary bladder sphincter dysfunction (HP:0002839)2.20588381
76Stereotypic behavior (HP:0000733)2.18493575
77EEG with generalized epileptiform discharges (HP:0011198)2.18405504
78Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.18159211
79Global brain atrophy (HP:0002283)2.17176027
80Intrahepatic cholestasis (HP:0001406)2.12270100
81Skin nodule (HP:0200036)2.11998193
82Annular pancreas (HP:0001734)2.11836826
83Abnormality of ocular smooth pursuit (HP:0000617)2.11824909
84Epidermoid cyst (HP:0200040)2.11619702
85Heart block (HP:0012722)2.11346914
86Impaired vibratory sensation (HP:0002495)2.08857860
87Menorrhagia (HP:0000132)2.08312021
88Cerebral aneurysm (HP:0004944)2.07640516
89Bradykinesia (HP:0002067)2.05091657
90Hypoventilation (HP:0002791)2.04217589
91Spontaneous abortion (HP:0005268)2.03725260
92Hydroureter (HP:0000072)2.03483992
93Lower limb asymmetry (HP:0100559)2.02377139
94Intention tremor (HP:0002080)2.01953753
95Hypsarrhythmia (HP:0002521)1.97345671
96Delusions (HP:0000746)1.96529310
97Protruding tongue (HP:0010808)1.96008119
98Atrioventricular block (HP:0001678)1.94897709
99Abnormal atrioventricular conduction (HP:0005150)1.92834402
100Lower limb amyotrophy (HP:0007210)1.91893145
101Incomplete penetrance (HP:0003829)1.90864132
102Urinary urgency (HP:0000012)1.89978709
103Pointed chin (HP:0000307)1.89721218
104Generalized myoclonic seizures (HP:0002123)1.88961947
105Mildly elevated creatine phosphokinase (HP:0008180)1.88457539
106Recurrent gram-negative bacterial infections (HP:0005420)1.88198309
107Craniofacial dystonia (HP:0012179)1.87520589
108J-shaped sella turcica (HP:0002680)1.87076244
109Sleep apnea (HP:0010535)1.86818399
110Rapidly progressive (HP:0003678)1.85895479
111Narrow nasal bridge (HP:0000446)1.85174290
112Purpura (HP:0000979)1.85136846
113Limb dystonia (HP:0002451)1.83737300
114Insomnia (HP:0100785)1.82103097
115Neonatal onset (HP:0003623)1.81843183
116Abnormality of salivation (HP:0100755)1.81432102
117Vascular calcification (HP:0004934)1.80734037
118Slender build (HP:0001533)1.80720860
119Retinal atrophy (HP:0001105)1.80356837
120Psychosis (HP:0000709)1.78810833
121Papilledema (HP:0001085)1.78054055
122Anosmia (HP:0000458)1.77458189
123Type II lissencephaly (HP:0007260)1.76045835
124Confusion (HP:0001289)1.75888174
125Abnormality of glutamine family amino acid metabolism (HP:0010902)1.73900404
126Abnormality of the periventricular white matter (HP:0002518)1.72962070
127Gait ataxia (HP:0002066)1.72774936
128Thickened helices (HP:0000391)1.72602101
129Bundle branch block (HP:0011710)1.72132538
130Spinal canal stenosis (HP:0003416)1.71915340
131Lower limb muscle weakness (HP:0007340)1.71486517
132Spastic gait (HP:0002064)1.71445918
133Abnormality of the Achilles tendon (HP:0005109)1.71095920
134Achilles tendon contracture (HP:0001771)1.70911880
135Alacrima (HP:0000522)1.70793975
136Clonus (HP:0002169)1.70112677
137Tetraplegia (HP:0002445)1.69623587
138Oligodactyly (hands) (HP:0001180)1.69445006
139Blue irides (HP:0000635)1.68577455
140Aplasia involving bones of the extremities (HP:0009825)1.68025952
141Aplasia involving bones of the upper limbs (HP:0009823)1.68025952
142Aplasia of the phalanges of the hand (HP:0009802)1.68025952
143Cerebral hypomyelination (HP:0006808)1.67911450
144Polyphagia (HP:0002591)1.67876308
145Syncope (HP:0001279)1.67829311
146Obstructive sleep apnea (HP:0002870)1.67281022
147Facial shape deformation (HP:0011334)1.67134861
148Potter facies (HP:0002009)1.67134861
149Ventricular fibrillation (HP:0001663)1.66856352
150Insidious onset (HP:0003587)1.66467212
151Termporal pattern (HP:0011008)1.66467212
152Hypoplastic nipples (HP:0002557)1.66000051
153Neoplasm of the heart (HP:0100544)1.65806324
154Arthropathy (HP:0003040)1.62949424
155Visceral angiomatosis (HP:0100761)1.57753103
156Fat malabsorption (HP:0002630)1.57030241
157Cardiovascular calcification (HP:0011915)1.56197439
158Abnormal gallbladder physiology (HP:0012438)1.55991262

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.82423165
2EPHA45.79401741
3MAP3K93.01993956
4RIPK42.77205920
5DAPK22.55670923
6FGFR42.48287171
7MAP3K42.41804378
8TNIK2.39345957
9MINK12.33216319
10WNK42.29920003
11PRKD32.10829897
12MAP2K72.07358278
13KSR12.03560431
14KSR21.99430970
15MAP2K41.93114215
16DAPK11.85522840
17PAK61.82411040
18PLK21.74633618
19PTK2B1.72019246
20SIK21.69056238
21MAP3K121.65870562
22FGFR21.60983852
23SIK11.60614569
24FGFR31.60289444
25STK381.59529675
26CASK1.58314832
27TRIB31.51074366
28PRPF4B1.49783305
29MAP3K131.43104389
30MARK11.42674193
31CAMKK11.42274392
32WNK11.38841003
33PRKCG1.35503283
34NTRK21.34569098
35ARAF1.32622944
36PNCK1.32020980
37CDK51.30842638
38BMPR21.26307201
39GRK51.23855268
40NTRK11.16686592
41MUSK1.14012604
42ICK1.13961217
43ERBB21.13873537
44MAP2K61.13668675
45CAMK2A1.13291790
46FES1.09325033
47CAMK2B1.09066977
48CAMK11.06462230
49RAF11.03812848
50NME11.02168649
51MAPK131.00261770
52FER0.94580523
53ERN10.94464991
54MAP3K20.93703847
55CDK190.92978455
56RIPK10.91001542
57DDR20.90846711
58TYRO30.89191614
59MAP3K70.88624439
60PIK3CA0.84090869
61MAP3K110.81270330
62PKN10.80988447
63LATS20.75350083
64SGK10.73688296
65SGK4940.73439362
66SGK2230.73439362
67PRKCH0.73243974
68FGR0.72160295
69PAK30.71854736
70MARK20.69491685
71PRKD20.69425134
72KDR0.68695427
73PINK10.68049618
74SGK20.68013996
75CDK180.67692868
76PRKAA10.66482353
77PRKAA20.65455558
78CDK150.65358776
79MAP3K60.65178695
80DMPK0.64538515
81MAP3K10.63741866
82PDPK10.63718328
83DYRK1A0.63289652
84STK110.63225853
85CAMKK20.60951118
86CAMK1G0.59710404
87FGFR10.58723101
88SGK30.58112127
89MAP2K10.57787018
90CDC42BPA0.57636788
91CDK11A0.56837113
92RPS6KA20.56530270
93CAMK2D0.56202404
94CDK140.56168144
95CAMK40.54977074
96UHMK10.54815246
97CAMK2G0.54733117
98DYRK1B0.53592312
99ROCK20.51518270
100PKN20.51355863
101PDK10.50922975
102MAPKAPK50.50784278
103PRKCZ0.50433547
104PDGFRA0.49313161
105RET0.48665181
106PRKCE0.47536209
107ROCK10.47393227
108AKT30.46503803
109PHKG10.44420770
110PHKG20.44420770
111EPHB20.43446926
112RPS6KA30.43267409
113PRKACG0.43066621
114TNK20.42025861
115EEF2K0.41834008
116SRC0.41579878
117NEK60.40001536
118MAPK80.39826650
119OXSR10.39823256
120SIK30.39700712
121BRSK10.39412834
122PRKD10.39179537
123PRKG10.38976856
124PRKACA0.38637943
125DAPK30.38512321
126CSNK1D0.38383859
127FYN0.38373073
128BRAF0.37742797
129PTK20.36680546
130MAPK120.35055582
131MAPK100.33575187
132TAOK20.33280568
133MOS0.31998906
134PRKCA0.31998005

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.16460739
2Long-term potentiation_Homo sapiens_hsa047203.08993516
3Circadian entrainment_Homo sapiens_hsa047132.79907510
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.73227015
5Glutamatergic synapse_Homo sapiens_hsa047242.71523810
6Synaptic vesicle cycle_Homo sapiens_hsa047212.69121091
7Amphetamine addiction_Homo sapiens_hsa050312.66515895
8GABAergic synapse_Homo sapiens_hsa047272.34228157
9Salivary secretion_Homo sapiens_hsa049702.29366134
10Morphine addiction_Homo sapiens_hsa050322.15278065
11Histidine metabolism_Homo sapiens_hsa003402.14509156
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.14078688
13Olfactory transduction_Homo sapiens_hsa047402.12187453
14Caffeine metabolism_Homo sapiens_hsa002322.07989294
15Phenylalanine metabolism_Homo sapiens_hsa003602.05276091
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.98548692
17Dopaminergic synapse_Homo sapiens_hsa047281.96948296
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.94461793
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.92146463
20Insulin secretion_Homo sapiens_hsa049111.89184435
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.87753579
22Retinol metabolism_Homo sapiens_hsa008301.81634999
23Gastric acid secretion_Homo sapiens_hsa049711.80492967
24Calcium signaling pathway_Homo sapiens_hsa040201.79525246
25Long-term depression_Homo sapiens_hsa047301.79028973
26Taste transduction_Homo sapiens_hsa047421.78278927
27Vitamin B6 metabolism_Homo sapiens_hsa007501.77024503
28Oxytocin signaling pathway_Homo sapiens_hsa049211.73677933
29Tyrosine metabolism_Homo sapiens_hsa003501.70879168
30Fatty acid degradation_Homo sapiens_hsa000711.70438004
31Renin secretion_Homo sapiens_hsa049241.65117414
32Cholinergic synapse_Homo sapiens_hsa047251.58070371
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53589668
34Chemical carcinogenesis_Homo sapiens_hsa052041.48031245
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.47123703
36GnRH signaling pathway_Homo sapiens_hsa049121.44755355
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43342497
38Serotonergic synapse_Homo sapiens_hsa047261.42265083
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.41650265
40PPAR signaling pathway_Homo sapiens_hsa033201.39566714
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36293917
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.35622037
43Nitrogen metabolism_Homo sapiens_hsa009101.34087916
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.32850247
45cAMP signaling pathway_Homo sapiens_hsa040241.29605358
46Arginine and proline metabolism_Homo sapiens_hsa003301.28007636
47Pentose and glucuronate interconversions_Homo sapiens_hsa000401.27126820
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26300414
49Collecting duct acid secretion_Homo sapiens_hsa049661.25053481
50ABC transporters_Homo sapiens_hsa020101.24792786
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.20937891
52Axon guidance_Homo sapiens_hsa043601.18085103
53Cocaine addiction_Homo sapiens_hsa050301.15737487
54Type II diabetes mellitus_Homo sapiens_hsa049301.13878447
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12645972
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11880236
57Melanogenesis_Homo sapiens_hsa049161.11604560
58Glioma_Homo sapiens_hsa052141.10902127
59Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10249498
60Gap junction_Homo sapiens_hsa045401.09452319
61cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08373932
62Estrogen signaling pathway_Homo sapiens_hsa049151.06746341
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06488981
64Linoleic acid metabolism_Homo sapiens_hsa005911.06017725
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.04472651
66Tryptophan metabolism_Homo sapiens_hsa003801.00387797
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00088603
68Fat digestion and absorption_Homo sapiens_hsa049750.94449360
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93503139
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.93215977
71beta-Alanine metabolism_Homo sapiens_hsa004100.90819867
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.90561998
73Thyroid hormone synthesis_Homo sapiens_hsa049180.89009264
74Arginine biosynthesis_Homo sapiens_hsa002200.88643672
75Bile secretion_Homo sapiens_hsa049760.86229169
76ErbB signaling pathway_Homo sapiens_hsa040120.85424957
77Cardiac muscle contraction_Homo sapiens_hsa042600.84326332
78Dilated cardiomyopathy_Homo sapiens_hsa054140.84150173
79Pancreatic secretion_Homo sapiens_hsa049720.83566859
80Biosynthesis of amino acids_Homo sapiens_hsa012300.83048741
81Fatty acid biosynthesis_Homo sapiens_hsa000610.80751927
82Glucagon signaling pathway_Homo sapiens_hsa049220.77241478
83Choline metabolism in cancer_Homo sapiens_hsa052310.76828034
84Starch and sucrose metabolism_Homo sapiens_hsa005000.76343948
85VEGF signaling pathway_Homo sapiens_hsa043700.73392249
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72702945
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.70464963
88Staphylococcus aureus infection_Homo sapiens_hsa051500.67396071
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.67175280
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66593932
91Fatty acid metabolism_Homo sapiens_hsa012120.66568414
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66188843
93Prion diseases_Homo sapiens_hsa050200.63774240
94Vibrio cholerae infection_Homo sapiens_hsa051100.63139501
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62294634
96Peroxisome_Homo sapiens_hsa041460.60812274
97Pyruvate metabolism_Homo sapiens_hsa006200.59811632
98Oocyte meiosis_Homo sapiens_hsa041140.58797228
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58257940
100MAPK signaling pathway_Homo sapiens_hsa040100.58013068
101African trypanosomiasis_Homo sapiens_hsa051430.57741499
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57172206
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.56364787
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.56231307
105Arachidonic acid metabolism_Homo sapiens_hsa005900.54713963
106Dorso-ventral axis formation_Homo sapiens_hsa043200.54028469
107Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53755051
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53120079
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.51653488
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50911980
111Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49439041
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48883442
113AMPK signaling pathway_Homo sapiens_hsa041520.48793057
114Circadian rhythm_Homo sapiens_hsa047100.47580639
115Wnt signaling pathway_Homo sapiens_hsa043100.47477745
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47433624
117Rap1 signaling pathway_Homo sapiens_hsa040150.46082242
118Ras signaling pathway_Homo sapiens_hsa040140.43700842
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.42679700
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41584958
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.41138314
122Other glycan degradation_Homo sapiens_hsa005110.40702998
123Inositol phosphate metabolism_Homo sapiens_hsa005620.39333480
124mTOR signaling pathway_Homo sapiens_hsa041500.38409659
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38245223
126Carbon metabolism_Homo sapiens_hsa012000.37727939
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35480463
128Alzheimers disease_Homo sapiens_hsa050100.35375538
129Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35101230
130Insulin resistance_Homo sapiens_hsa049310.34702833
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33547535
132Sulfur relay system_Homo sapiens_hsa041220.33224868
133Phototransduction_Homo sapiens_hsa047440.32904359
134Insulin signaling pathway_Homo sapiens_hsa049100.29949120
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29458888
136Butanoate metabolism_Homo sapiens_hsa006500.24040217
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.23193961
138Glycerolipid metabolism_Homo sapiens_hsa005610.21205021
139Ovarian steroidogenesis_Homo sapiens_hsa049130.19202542
140Complement and coagulation cascades_Homo sapiens_hsa046100.18353568
141Non-small cell lung cancer_Homo sapiens_hsa052230.17810535
142Type I diabetes mellitus_Homo sapiens_hsa049400.17567495
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17130678
144Mineral absorption_Homo sapiens_hsa049780.16869319
145Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.16781855
146Regulation of actin cytoskeleton_Homo sapiens_hsa048100.16590725
147Endometrial cancer_Homo sapiens_hsa052130.15423203

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