CHRDL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)5.82623550
2low-density lipoprotein particle clearance (GO:0034383)5.54850840
3cartilage development involved in endochondral bone morphogenesis (GO:0060351)5.53578042
4keratan sulfate catabolic process (GO:0042340)5.48291540
5glycerolipid catabolic process (GO:0046503)4.79981727
6chondrocyte development (GO:0002063)4.76865098
7white fat cell differentiation (GO:0050872)4.75452578
8collagen fibril organization (GO:0030199)4.74267342
9endothelial cell morphogenesis (GO:0001886)4.54378923
10negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)4.33864710
11brown fat cell differentiation (GO:0050873)4.24501887
12fatty acid homeostasis (GO:0055089)4.22154731
13regulation of sequestering of triglyceride (GO:0010889)4.18119454
14regulation of gonadotropin secretion (GO:0032276)4.06981299
15negative regulation of gluconeogenesis (GO:0045721)4.06165065
16negative regulation of smooth muscle cell migration (GO:0014912)4.05723895
17positive regulation of fatty acid oxidation (GO:0046321)4.03078964
18polyol transport (GO:0015791)4.01655502
19retina vasculature morphogenesis in camera-type eye (GO:0061299)3.99708549
20regulation of cAMP-dependent protein kinase activity (GO:2000479)3.96237906
21positive regulation of fatty acid beta-oxidation (GO:0032000)3.95352627
22lipid storage (GO:0019915)3.89903357
23cellular response to epinephrine stimulus (GO:0071872)3.86990495
24positive regulation of glomerulus development (GO:0090193)3.85048196
25triglyceride catabolic process (GO:0019433)3.83912943
26negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.83649996
27blood vessel maturation (GO:0001955)3.83349484
28positive regulation of extracellular matrix organization (GO:1903055)3.81628058
29diacylglycerol metabolic process (GO:0046339)3.78776519
30valine metabolic process (GO:0006573)3.75033136
31negative regulation of granulocyte differentiation (GO:0030853)3.74771497
32cell aggregation (GO:0098743)3.71812271
33cartilage condensation (GO:0001502)3.71812271
34ethanol oxidation (GO:0006069)3.68075386
35negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.67749117
36negative regulation of amino acid transport (GO:0051956)3.67180640
37extracellular fibril organization (GO:0043206)3.62621911
38NADH metabolic process (GO:0006734)3.56591856
39protein localization to cell surface (GO:0034394)3.54788139
40regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.50817607
41regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.49788443
42barbed-end actin filament capping (GO:0051016)3.45550239
43regulation of glycogen (starch) synthase activity (GO:2000465)3.43524735
44collagen metabolic process (GO:0032963)3.42796613
45acylglycerol catabolic process (GO:0046464)3.42171222
46neutral lipid catabolic process (GO:0046461)3.42171222
47collagen catabolic process (GO:0030574)3.42109401
48basement membrane organization (GO:0071711)3.41026424
49positive regulation of cholesterol efflux (GO:0010875)3.36393707
50multicellular organismal macromolecule metabolic process (GO:0044259)3.36082016
51regulation of endothelial cell differentiation (GO:0045601)3.34252230
52positive regulation of metanephros development (GO:0072216)3.31138083
53regulation of lipoprotein metabolic process (GO:0050746)3.30126894
54endocrine hormone secretion (GO:0060986)3.29418471
55multicellular organismal metabolic process (GO:0044236)3.29134284
56notochord development (GO:0030903)3.28688808
57chondrocyte proliferation (GO:0035988)3.28452743
58plasma lipoprotein particle clearance (GO:0034381)3.26695168
59regulation of cholesterol storage (GO:0010885)3.24624547
60cGMP-mediated signaling (GO:0019934)3.24431231
61phagocytosis, recognition (GO:0006910)3.24327249
62negative regulation of protein autophosphorylation (GO:0031953)3.24160478
63response to epinephrine (GO:0071871)3.21791181
64positive regulation of cellular response to insulin stimulus (GO:1900078)3.21420564
65positive regulation of glycolytic process (GO:0045821)3.20338520
66negative regulation of metanephros development (GO:0072217)3.17380351
67peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.16868015
68regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)3.15506462
69multicellular organismal catabolic process (GO:0044243)3.15111533
70negative regulation of macrophage differentiation (GO:0045650)3.14793161
71positive regulation of insulin receptor signaling pathway (GO:0046628)3.14307116
72positive regulation of chondrocyte differentiation (GO:0032332)3.13259001
73CDP-diacylglycerol biosynthetic process (GO:0016024)3.12522686
74cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.12020495
75regulation of macrophage derived foam cell differentiation (GO:0010743)3.11593651
76glomerular filtration (GO:0003094)3.10755402
77iron ion import (GO:0097286)3.10697902
78positive regulation of lipid storage (GO:0010884)3.10663782
79positive regulation of glycogen biosynthetic process (GO:0045725)3.09364159
80triglyceride metabolic process (GO:0006641)3.08612116
81fibril organization (GO:0097435)3.06536166
82CDP-diacylglycerol metabolic process (GO:0046341)3.06070160
83positive regulation of glucose transport (GO:0010828)3.04675882
84L-serine transport (GO:0015825)3.04298966
85chondroitin sulfate biosynthetic process (GO:0030206)3.02832102
86positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.99016006
87primary alcohol metabolic process (GO:0034308)2.98480715
88positive regulation of cartilage development (GO:0061036)2.96937987
89extracellular matrix assembly (GO:0085029)2.95212665
90fatty acid transmembrane transport (GO:1902001)2.93646463
91positive regulation of sterol transport (GO:0032373)2.93162385
92positive regulation of cholesterol transport (GO:0032376)2.93162385
93growth hormone receptor signaling pathway (GO:0060396)2.92201850
94cellular response to leptin stimulus (GO:0044320)2.90393511
95negative regulation of smooth muscle cell proliferation (GO:0048662)2.90235248
96renal filtration (GO:0097205)2.88938850
97ovulation from ovarian follicle (GO:0001542)2.88589328
98alanine transport (GO:0032328)2.88125101
99insulin-like growth factor receptor signaling pathway (GO:0048009)2.88106309
100fibroblast migration (GO:0010761)2.87624552
101cellular response to vitamin (GO:0071295)2.85833170
102dermatan sulfate biosynthetic process (GO:0030208)2.85405528
103biotin metabolic process (GO:0006768)2.84582876
104ethanol metabolic process (GO:0006067)2.84321068
105negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.84099297
106metanephric nephron epithelium development (GO:0072243)2.82718727
107acylglycerol metabolic process (GO:0006639)2.82627673
108lipid particle organization (GO:0034389)2.82244335
109negative regulation of endothelial cell proliferation (GO:0001937)2.82187797
110positive regulation of glucose import (GO:0046326)2.80966025
111positive regulation of p38MAPK cascade (GO:1900745)2.78560712
112neutral lipid metabolic process (GO:0006638)2.78484424
113axon extension involved in axon guidance (GO:0048846)2.77832462
114neuron projection extension involved in neuron projection guidance (GO:1902284)2.77832462
115peptidyl-proline hydroxylation (GO:0019511)2.77661630
116keratan sulfate biosynthetic process (GO:0018146)2.77598188
117negative regulation of cartilage development (GO:0061037)2.77165476
118extracellular matrix disassembly (GO:0022617)2.76790473
119negative regulation of DNA biosynthetic process (GO:2000279)2.74958971
120cartilage development (GO:0051216)2.74860191
121limb bud formation (GO:0060174)2.74042120
122metanephric nephron tubule development (GO:0072234)2.73694385
123metanephric tubule development (GO:0072170)2.73694385
124regulation of fatty acid beta-oxidation (GO:0031998)2.73168779
125positive regulation of fatty acid metabolic process (GO:0045923)2.72570590
126apoptotic cell clearance (GO:0043277)2.71339983
127triglyceride biosynthetic process (GO:0019432)2.69877594
128retinol metabolic process (GO:0042572)2.69675021
129regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.69607844
130vascular endothelial growth factor signaling pathway (GO:0038084)2.69542447
131endocardial cushion morphogenesis (GO:0003203)2.68619627
132response to gravity (GO:0009629)2.68520651
133replacement ossification (GO:0036075)2.67908688
134endochondral ossification (GO:0001958)2.67908688
135negative regulation of appetite (GO:0032099)2.66962145
136negative regulation of response to food (GO:0032096)2.66962145
137dermatan sulfate metabolic process (GO:0030205)2.66381372
138regulation of glucose import in response to insulin stimulus (GO:2001273)2.66093970
139negative regulation of chondrocyte differentiation (GO:0032331)2.64688496
140response to phenylpropanoid (GO:0080184)2.64482850
141regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.63232489
142positive regulation of endothelial cell differentiation (GO:0045603)2.61628815
143regulation of glomerulus development (GO:0090192)2.61443925
144endothelium development (GO:0003158)2.59609753
145protein retention in ER lumen (GO:0006621)2.59511953
146response to dietary excess (GO:0002021)2.59362451
147endodermal cell differentiation (GO:0035987)2.59146720
148negative regulation of catenin import into nucleus (GO:0035414)2.58461490
149transcytosis (GO:0045056)2.58274055
150positive regulation of glycogen metabolic process (GO:0070875)2.58253910
151positive regulation of endothelial cell apoptotic process (GO:2000353)2.57850844
152cellular response to BMP stimulus (GO:0071773)2.57275437
153response to BMP (GO:0071772)2.57275437
154positive regulation of fat cell differentiation (GO:0045600)2.57137558
155acylglycerol biosynthetic process (GO:0046463)2.56184086
156neutral lipid biosynthetic process (GO:0046460)2.56184086
157regulation of chondrocyte differentiation (GO:0032330)2.54177945
158negative regulation of fatty acid transport (GO:2000192)2.52252246
159alpha-linolenic acid metabolic process (GO:0036109)2.51535352
160cellular response to growth hormone stimulus (GO:0071378)2.51294894

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.93687243
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.37698593
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.41446664
4CLOCK_20551151_ChIP-Seq_293T_Human3.61227824
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.76219975
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.58250107
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.49668833
8EZH2_22144423_ChIP-Seq_EOC_Human2.46166583
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.42295467
10AR_21572438_ChIP-Seq_LNCaP_Human2.42032866
11ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.35065130
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.08579710
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.05880668
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.03686039
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.01522848
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.01522848
17ESR2_21235772_ChIP-Seq_MCF-7_Human1.97538733
18EED_16625203_ChIP-ChIP_MESCs_Mouse1.97244315
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.93093013
20HIF1A_21447827_ChIP-Seq_MCF-7_Human1.89771198
21* CJUN_26792858_Chip-Seq_BT549_Human1.84094960
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.83142031
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.80107586
24TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.78755358
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.78263643
26CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.72201784
27* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.66205375
28WT1_19549856_ChIP-ChIP_CCG9911_Human1.63750720
29CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.59132743
30PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.58657392
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.52832332
32* EZH2_27304074_Chip-Seq_ESCs_Mouse1.51063771
33RXR_22108803_ChIP-Seq_LS180_Human1.49436432
34BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.48640015
35NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.47770540
36NRF2_20460467_ChIP-Seq_MEFs_Mouse1.47770540
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47763916
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.47658582
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.46967577
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45634734
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42689463
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41322555
43EP300_21415370_ChIP-Seq_HL-1_Mouse1.41181961
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40911173
45RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.37706631
46GATA2_21666600_ChIP-Seq_HMVEC_Human1.36369414
47EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.35730031
48PPAR_26484153_Chip-Seq_NCI-H1993_Human1.29132734
49JARID2_20064375_ChIP-Seq_MESCs_Mouse1.28898340
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26783317
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26047446
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.25702107
53* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.24510885
54SALL4_18804426_ChIP-ChIP_XEN_Mouse1.23386789
55GATA1_22025678_ChIP-Seq_K562_Human1.22121506
56SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.21236757
57KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.21159759
58KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.21159759
59KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.21159759
60FOXO3_23340844_ChIP-Seq_DLD1_Human1.19973420
61LXR_22158963_ChIP-Seq_LIVER_Mouse1.18779759
62TBX20_22328084_ChIP-Seq_HEART_Mouse1.17930723
63TBX20_22080862_ChIP-Seq_HEART_Mouse1.17930723
64PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.16116469
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15927087
66VDR_24787735_ChIP-Seq_THP-1_Human1.15487714
67TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.14880677
68ESR1_20079471_ChIP-ChIP_T-47D_Human1.14537317
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.14407644
70TP53_18474530_ChIP-ChIP_U2OS_Human1.14158386
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13677401
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.11143747
73SOX2_20726797_ChIP-Seq_SW620_Human1.09856363
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09567181
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09467971
76TP53_16413492_ChIP-PET_HCT116_Human1.08790282
77NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.07385219
78SA1_22415368_ChIP-Seq_MEFs_Mouse1.06929488
79* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06796121
80TCF4_18268006_ChIP-ChIP_LS174T_Human1.05371296
81MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04951174
82GBX2_23144817_ChIP-Seq_PC3_Human1.04936655
83TP53_20018659_ChIP-ChIP_R1E_Mouse1.04350998
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04039211
85ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.03649827
86BRD4_25478319_ChIP-Seq_HGPS_Human1.03226380
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02453378
88ISL1_27105846_Chip-Seq_CPCs_Mouse1.01794534
89TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01088321
90ERG_21242973_ChIP-ChIP_JURKAT_Human0.99953718
91SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99952856
92* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98947111
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96814815
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96079325
95BCAT_22108803_ChIP-Seq_LS180_Human0.95724262
96JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94909554
97AHR_22903824_ChIP-Seq_MCF-7_Human0.94343023
98DROSHA_22980978_ChIP-Seq_HELA_Human0.94281688
99KDM2B_26808549_Chip-Seq_K562_Human0.92978949
100PPARA_22158963_ChIP-Seq_LIVER_Mouse0.92973076
101RING1B_27294783_Chip-Seq_ESCs_Mouse0.92674883
102CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92580337
103FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90545829
104WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90346140
105PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89351358
106RXR_22158963_ChIP-Seq_LIVER_Mouse0.88951245
107SUZ12_27294783_Chip-Seq_ESCs_Mouse0.87554499
108HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87501949
109SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87216731
110RING1B_27294783_Chip-Seq_NPCs_Mouse0.86499457
111EZH2_27294783_Chip-Seq_ESCs_Mouse0.86493366
112JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86375952
113TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85410151
114SMAD4_21799915_ChIP-Seq_A2780_Human0.85331588
115SMC3_22415368_ChIP-Seq_MEFs_Mouse0.85203286
116OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84624096
117CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.84623158
118DNAJC2_21179169_ChIP-ChIP_NT2_Human0.83161701
119ARNT_22903824_ChIP-Seq_MCF-7_Human0.82856384
120RBPJ_22232070_ChIP-Seq_NCS_Mouse0.82633126
121SMC1_22415368_ChIP-Seq_MEFs_Mouse0.81716400
122SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.81588609

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.35524382
2MP0005670_abnormal_white_adipose4.60045502
3MP0005503_abnormal_tendon_morphology4.55960539
4MP0005275_abnormal_skin_tensile3.59173740
5MP0004272_abnormal_basement_membrane3.58087779
6MP0000013_abnormal_adipose_tissue3.36346064
7MP0004185_abnormal_adipocyte_glucose3.23967495
8MP0005666_abnormal_adipose_tissue3.13725832
9MP0004130_abnormal_muscle_cell2.87877592
10MP0009780_abnormal_chondrocyte_physiolo2.68497441
11MP0003279_aneurysm2.67667698
12MP0004134_abnormal_chest_morphology2.64422743
13MP0003705_abnormal_hypodermis_morpholog2.60372586
14MP0005375_adipose_tissue_phenotype2.45728556
15MP0003011_delayed_dark_adaptation2.16508237
16MP0003959_abnormal_lean_body2.13476581
17MP0000003_abnormal_adipose_tissue2.11130514
18MP0000163_abnormal_cartilage_morphology2.04156843
19MP0002933_joint_inflammation1.99567210
20MP0001958_emphysema1.98986848
21MP0005167_abnormal_blood-brain_barrier1.97584563
22MP0009250_abnormal_appendicular_skeleto1.96327494
23MP0005508_abnormal_skeleton_morphology1.79991638
24MP0006054_spinal_hemorrhage1.77718707
25MP0000751_myopathy1.75269255
26MP0002115_abnormal_skeleton_extremities1.72671225
27MP0002638_abnormal_pupillary_reflex1.69687694
28MP0009384_cardiac_valve_regurgitation1.67565943
29MP0002282_abnormal_trachea_morphology1.66123820
30MP0005535_abnormal_body_temperature1.65880331
31MP0001879_abnormal_lymphatic_vessel1.64475943
32MP0003950_abnormal_plasma_membrane1.58665563
33MP0002108_abnormal_muscle_morphology1.56983015
34MP0009115_abnormal_fat_cell1.54386672
35MP0002909_abnormal_adrenal_gland1.53101088
36MP0002876_abnormal_thyroid_physiology1.51668495
37MP0003646_muscle_fatigue1.51396918
38MP0002896_abnormal_bone_mineralization1.49386620
39MP0003868_abnormal_feces_composition1.47979420
40MP0002971_abnormal_brown_adipose1.44814104
41MP0002837_dystrophic_cardiac_calcinosis1.42453491
42MP0000343_altered_response_to1.39128648
43MP0003123_paternal_imprinting1.35668660
44MP0001501_abnormal_sleep_pattern1.32333620
45MP0010329_abnormal_lipoprotein_level1.31726811
46MP0005164_abnormal_response_to1.30170689
47MP0001270_distended_abdomen1.29582630
48MP0001661_extended_life_span1.29568110
49MP0005595_abnormal_vascular_smooth1.26914266
50MP0005448_abnormal_energy_balance1.25667532
51MP0004215_abnormal_myocardial_fiber1.24611711
52MP0005334_abnormal_fat_pad1.23029443
53MP0001299_abnormal_eye_distance/1.22576444
54MP0002113_abnormal_skeleton_development1.21907487
55MP0006138_congestive_heart_failure1.21714987
56MP0005390_skeleton_phenotype1.18941594
57MP0005379_endocrine/exocrine_gland_phen1.18431115
58MP0002254_reproductive_system_inflammat1.18367983
59MP0003566_abnormal_cell_adhesion1.18094820
60MP0002295_abnormal_pulmonary_circulatio1.17964793
61MP0005623_abnormal_meninges_morphology1.17404038
62MP0006276_abnormal_autonomic_nervous1.16319910
63MP0005452_abnormal_adipose_tissue1.11234133
64MP0003787_abnormal_imprinting1.10436330
65MP0002089_abnormal_postnatal_growth/wei1.09472379
66MP0003122_maternal_imprinting1.08273389
67MP0004087_abnormal_muscle_fiber1.07705866
68MP0002060_abnormal_skin_morphology1.05869001
69MP0000749_muscle_degeneration1.03987526
70MP0000759_abnormal_skeletal_muscle1.02877397
71MP0002109_abnormal_limb_morphology1.01104069
72MP0004084_abnormal_cardiac_muscle1.00766711
73MP0000767_abnormal_smooth_muscle1.00725412
74MP0001533_abnormal_skeleton_physiology0.98972535
75MP0003385_abnormal_body_wall0.97980707
76MP0010368_abnormal_lymphatic_system0.96881578
77MP0002163_abnormal_gland_morphology0.96576509
78MP0002998_abnormal_bone_remodeling0.94779370
79MP0004036_abnormal_muscle_relaxation0.93761403
80MP0001542_abnormal_bone_strength0.92367495
81MP0004484_altered_response_of0.90764756
82MP0002970_abnormal_white_adipose0.90597947
83MP0000762_abnormal_tongue_morphology0.89859280
84MP0003690_abnormal_glial_cell0.89433508
85MP0003948_abnormal_gas_homeostasis0.89178401
86MP0000566_synostosis0.87403090
87MP0003045_fibrosis0.86074594
88MP0003091_abnormal_cell_migration0.85932724
89MP0004782_abnormal_surfactant_physiolog0.85724088
90MP0001177_atelectasis0.85349053
91MP0003283_abnormal_digestive_organ0.85141617
92MP0005647_abnormal_sex_gland0.80915404
93MP0008775_abnormal_heart_ventricle0.79123316
94MP0003121_genomic_imprinting0.77411064
95MP0005385_cardiovascular_system_phenoty0.77006009
96MP0001544_abnormal_cardiovascular_syste0.77006009
97MP0002249_abnormal_larynx_morphology0.76554362
98MP0004883_abnormal_blood_vessel0.73625799
99MP0002078_abnormal_glucose_homeostasis0.72096333
100MP0003828_pulmonary_edema0.71795244
101MP0000230_abnormal_systemic_arterial0.71339312
102MP0003795_abnormal_bone_structure0.71011944
103MP0000249_abnormal_blood_vessel0.70972068
104MP0005620_abnormal_muscle_contractility0.70712686
105MP0010386_abnormal_urinary_bladder0.69567971
106MP0010030_abnormal_orbit_morphology0.69009988
107MP0003724_increased_susceptibility_to0.68760721
108MP0005369_muscle_phenotype0.67137934
109MP0003191_abnormal_cellular_cholesterol0.66697739
110MP0003942_abnormal_urinary_system0.66408647
111MP0002118_abnormal_lipid_homeostasis0.66359155
112MP0005023_abnormal_wound_healing0.65580811
113MP0004858_abnormal_nervous_system0.64738717
114MP0002128_abnormal_blood_circulation0.63433292
115MP0002133_abnormal_respiratory_system0.63362151
116MP0005388_respiratory_system_phenotype0.63362151
117MP0000750_abnormal_muscle_regeneration0.62046100
118MP0002116_abnormal_craniofacial_bone0.61962713
119MP0000049_abnormal_middle_ear0.61361788
120MP0003137_abnormal_impulse_conducting0.61058692
121MP0001614_abnormal_blood_vessel0.59610273
122MP0001727_abnormal_embryo_implantation0.58841890
123MP0002972_abnormal_cardiac_muscle0.58796867
124MP0000534_abnormal_ureter_morphology0.58282887
125MP0001881_abnormal_mammary_gland0.57656503
126MP0003186_abnormal_redox_activity0.56552538
127MP0002111_abnormal_tail_morphology0.55840087
128MP0001502_abnormal_circadian_rhythm0.55302459
129MP0010630_abnormal_cardiac_muscle0.55124044
130MP0003879_abnormal_hair_cell0.51861490
131MP0000733_abnormal_muscle_development0.46846702
132MP0005257_abnormal_intraocular_pressure0.46827397

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)7.22924467
2Irregular epiphyses (HP:0010582)5.57379106
3Vitreoretinal degeneration (HP:0000655)5.15183576
4Neonatal short-limb short stature (HP:0008921)4.85210123
5Cupped ribs (HP:0000887)4.83097348
6Hypertriglyceridemia (HP:0002155)4.63986230
7Hypoplastic ischia (HP:0003175)4.61071906
8Abnormal tarsal ossification (HP:0008369)4.59673422
9Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.24920231
10Small epiphyses (HP:0010585)4.23864425
11Abnormality of the ischium (HP:0003174)4.10552645
12Protrusio acetabuli (HP:0003179)3.98957187
13Flat acetabular roof (HP:0003180)3.87072896
14Metaphyseal dysplasia (HP:0100255)3.70267379
15Vascular tortuosity (HP:0004948)3.61363805
16Follicular hyperkeratosis (HP:0007502)3.60461461
17Abnormal foot bone ossification (HP:0010675)3.57216056
18Osteoarthritis (HP:0002758)3.54662733
19Muscle fiber splitting (HP:0003555)3.51308832
20Flat capital femoral epiphysis (HP:0003370)3.43509822
21Vertebral compression fractures (HP:0002953)3.39549604
22Difficulty running (HP:0009046)3.38821459
23Ankle contracture (HP:0006466)3.32831563
24Cerebral aneurysm (HP:0004944)3.30449712
25Cervical subluxation (HP:0003308)3.29344896
26Insulin resistance (HP:0000855)3.28280334
27Premature rupture of membranes (HP:0001788)3.23667683
28Abnormal eating behavior (HP:0100738)3.22498448
29Arterial tortuosity (HP:0005116)3.20850448
30Genu varum (HP:0002970)3.17348362
31Complement deficiency (HP:0004431)3.16145157
32Delayed epiphyseal ossification (HP:0002663)3.16082629
33Mild short stature (HP:0003502)3.13510812
34Metaphyseal cupping (HP:0003021)3.08045003
35Myocardial infarction (HP:0001658)3.02835762
36Abnormality of the vertebral endplates (HP:0005106)3.01696926
37Abnormality of complement system (HP:0005339)2.96743982
38Short femoral neck (HP:0100864)2.89196821
39Skin nodule (HP:0200036)2.84990560
40Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.84951767
41Abnormality of femoral epiphyses (HP:0006499)2.84951767
42Pulmonary artery stenosis (HP:0004415)2.83336454
43Striae distensae (HP:0001065)2.77848732
44Abnormality of the phalanges of the 2nd finger (HP:0009541)2.76939047
45Abnormality of carpal bone ossification (HP:0006257)2.74198636
46Platyspondyly (HP:0000926)2.72727536
47Flattened epiphyses (HP:0003071)2.67516941
48Limited hip movement (HP:0008800)2.66878777
49Coxa vara (HP:0002812)2.66434546
50Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.66197328
51Fibular hypoplasia (HP:0003038)2.66029953
52Overgrowth (HP:0001548)2.63400446
53Back pain (HP:0003418)2.62841557
54Aortic aneurysm (HP:0004942)2.62522689
55Irregular vertebral endplates (HP:0003301)2.62102117
56Wrist flexion contracture (HP:0001239)2.61064178
57Oligomenorrhea (HP:0000876)2.60826175
58Acanthosis nigricans (HP:0000956)2.59667626
59Broad metatarsal (HP:0001783)2.59657166
60Type 1 muscle fiber predominance (HP:0003803)2.58717275
61Neoplasm of the adrenal cortex (HP:0100641)2.58139357
62Bone cyst (HP:0012062)2.56107496
63Hyperlipoproteinemia (HP:0010980)2.54595362
64Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.54067701
65Absent epiphyses (HP:0010577)2.54067701
66Hemorrhage of the eye (HP:0011885)2.53214647
67Dilatation of the ascending aorta (HP:0005111)2.52943219
68Aortic dissection (HP:0002647)2.51559212
69Ovoid vertebral bodies (HP:0003300)2.50335929
70Thoracolumbar scoliosis (HP:0002944)2.49582791
71Pigmentary retinal degeneration (HP:0001146)2.49176828
72Abnormality of the epiphysis of the femoral head (HP:0010574)2.48776618
73Prominent supraorbital ridges (HP:0000336)2.48520237
74Hypoplasia of the iris (HP:0007676)2.48301590
75Lipoatrophy (HP:0100578)2.45496367
76Coronal craniosynostosis (HP:0004440)2.45469045
77Spinal rigidity (HP:0003306)2.43972575
78Abnormal vertebral ossification (HP:0100569)2.42883493
79Metaphyseal irregularity (HP:0003025)2.41375319
80Abnormality of the middle phalanges of the toes (HP:0010183)2.40816086
81Lumbar hyperlordosis (HP:0002938)2.40486721
82Abnormal ossification of hand bones (HP:0005921)2.38389464
83Reduced subcutaneous adipose tissue (HP:0003758)2.37317194
84Hypercortisolism (HP:0001578)2.37244513
85Insulin-resistant diabetes mellitus (HP:0000831)2.37098788
86Aneurysm (HP:0002617)2.35807513
87Abnormality of the 2nd finger (HP:0004100)2.35766214
88Aortic regurgitation (HP:0001659)2.35707262
89Beaking of vertebral bodies (HP:0004568)2.34064961
90Abnormality of the lumbar spine (HP:0100712)2.34010019
91Epidermoid cyst (HP:0200040)2.33399549
92Osteolytic defects of the phalanges of the hand (HP:0009771)2.32239967
93Osteolytic defects of the hand bones (HP:0009699)2.32239967
94Hip contracture (HP:0003273)2.31250195
95Abnormal hand bone ossification (HP:0010660)2.30636819
96Soft skin (HP:0000977)2.30603559
97Hepatoblastoma (HP:0002884)2.30362664
98Abnormality of the femoral head (HP:0003368)2.29453590
99Protuberant abdomen (HP:0001538)2.28555555
100Aplasia/hypoplasia of the femur (HP:0005613)2.28361234
101Increased variability in muscle fiber diameter (HP:0003557)2.28138724
102Slender build (HP:0001533)2.26153951
103Infantile muscular hypotonia (HP:0008947)2.25955731
104Neonatal hypoglycemia (HP:0001998)2.24876062
105Arthropathy (HP:0003040)2.24757838
106Limited elbow extension (HP:0001377)2.24632931
107Accelerated skeletal maturation (HP:0005616)2.24564421
108Growth hormone excess (HP:0000845)2.24480128
109Systemic lupus erythematosus (HP:0002725)2.24026658
110Action tremor (HP:0002345)2.23007078
111Aplasia involving bones of the upper limbs (HP:0009823)2.21950613
112Aplasia of the phalanges of the hand (HP:0009802)2.21950613
113Aplasia involving bones of the extremities (HP:0009825)2.21950613
114Obstructive sleep apnea (HP:0002870)2.21948747
115Lymphangioma (HP:0100764)2.21829848
116Abnormality of the pubic bones (HP:0003172)2.21735934
117Absent frontal sinuses (HP:0002688)2.21595765
118Abnormality of the proximal phalanges of the hand (HP:0009834)2.20938117
119Mesomelia (HP:0003027)2.18781797
120Polycythemia (HP:0001901)2.16818495
121Exostoses (HP:0100777)2.15783083
122Abnormality of the acetabulum (HP:0003170)2.15616300
123Hyporeflexia of lower limbs (HP:0002600)2.15014023
124Neck muscle weakness (HP:0000467)2.13334739
125Amyloidosis (HP:0011034)2.13151645
126Abnormality of incisor morphology (HP:0011063)2.10854751
127Polar cataract (HP:0010696)2.10451487
128Mitral valve prolapse (HP:0001634)2.10276001
129Increased connective tissue (HP:0009025)2.08524839
130Mitral regurgitation (HP:0001653)2.06331409
131Aortic valve stenosis (HP:0001650)2.06040837
132Wide anterior fontanel (HP:0000260)2.04560484
133Short hallux (HP:0010109)2.02855283
134Thin ribs (HP:0000883)2.02765713
135Frequent falls (HP:0002359)2.02248413
136Hypoplasia of the odontoid process (HP:0003311)2.02145955
137Wormian bones (HP:0002645)2.01990220
138Long foot (HP:0001833)2.01809486
139Axonal loss (HP:0003447)2.01749706
140Scapular winging (HP:0003691)2.00680989
141Abnormality of the vitreous humor (HP:0004327)2.00395789
142Abnormality of dentin (HP:0010299)1.98459290
143Myotonia (HP:0002486)1.98168441
144Gowers sign (HP:0003391)1.97762905
145Stillbirth (HP:0003826)1.97632467
146Polyphagia (HP:0002591)1.96897735
147Biconcave vertebral bodies (HP:0004586)1.96867257
148Waddling gait (HP:0002515)1.96703901
149Nuclear cataract (HP:0100018)1.96088195
150Turricephaly (HP:0000262)1.94679770
151Subcapsular cataract (HP:0000523)1.93942439
152Bronchomalacia (HP:0002780)1.93225558
153Micromelia (HP:0002983)1.93104044
154Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.92750831
155Ulnar bowing (HP:0003031)1.91947275
156Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.91823715
157Broad long bones (HP:0005622)1.90854175
158Abnormality of skeletal muscle fiber size (HP:0012084)1.89849260
159Shallow orbits (HP:0000586)1.88658809
160Enlarged epiphyses (HP:0010580)1.88010117
161Bladder diverticulum (HP:0000015)1.85339662
162Blue sclerae (HP:0000592)1.81346385
163Abnormal hemoglobin (HP:0011902)1.81174623
164Glucose intolerance (HP:0000833)1.81148447
165Venous abnormality (HP:0002624)1.77696636
166Foot dorsiflexor weakness (HP:0009027)1.77451831
167Atrioventricular block (HP:0001678)1.77391948
168Hyperextensible skin (HP:0000974)1.75483466
169Joint laxity (HP:0001388)1.74589949
170Joint stiffness (HP:0001387)1.72523181
171Delayed cranial suture closure (HP:0000270)1.71759759
172Bradycardia (HP:0001662)1.71678145
173Spinal cord lesions (HP:0100561)1.71380921
174Syringomyelia (HP:0003396)1.71380921
175Hypercholesterolemia (HP:0003124)1.70041487
176Mitral stenosis (HP:0001718)1.69535208
177Ulnar claw (HP:0001178)1.69332423
178Mildly elevated creatine phosphokinase (HP:0008180)1.68014714

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK14.53755673
2TRIB34.38610068
3DDR24.30095531
4LATS13.31752103
5CAMK1D2.80469925
6TIE12.68048805
7LMTK22.53891637
8RIPK12.41972194
9MAP3K32.38634957
10PDK22.34259621
11STK38L2.25347760
12TESK12.14223312
13CAMK12.10929311
14CAMK1G1.99452383
15MAP3K61.97822606
16EPHB21.96476851
17GRK51.87662244
18PDGFRA1.86274639
19ERN11.73336241
20FGFR31.70861710
21LATS21.67695966
22PRKG21.67046364
23FGFR21.66956107
24MARK11.55112654
25CAMKK21.50982163
26PTK2B1.48845712
27PRKD31.46333076
28TRPM71.43209886
29STK31.41769944
30KDR1.39288168
31ABL21.38510034
32MAPK41.38109594
33EEF2K1.37899338
34CDC42BPA1.35047625
35EPHA41.32716877
36MOS1.31587547
37STK241.30540929
38MAPK121.28379214
39PIK3CA1.28210389
40FRK1.27797677
41PHKG21.23192323
42PHKG11.23192323
43PDK31.21823734
44PDK41.21823734
45MYLK1.21367510
46TGFBR21.20088402
47FER1.19096996
48NME11.16976294
49NLK1.12655858
50TTN1.11604180
51CDK91.08518249
52DMPK1.04614316
53MST1R0.99523437
54ROCK10.97368966
55EPHA30.94898577
56PTK60.94439227
57PKN20.93676779
58PLK20.93456292
59NUAK10.92553940
60BCKDK0.89823939
61PRKAA20.86846616
62FGFR10.86717374
63PKN10.86242644
64MAPKAPK30.85298402
65MAP2K10.82620275
66DAPK30.82593333
67MET0.82439002
68PAK20.79671124
69PRKG10.78362886
70NEK90.78057519
71PDGFRB0.77203887
72MAPK70.74853601
73MARK20.70478138
74KIT0.68841018
75PRKAA10.66143753
76NTRK30.64262659
77IGF1R0.63955128
78MUSK0.63751792
79GSK3A0.62081422
80KSR10.61460484
81PINK10.61398217
82PAK40.61374131
83SGK30.61004266
84CDK60.60717710
85ARAF0.60506116
86MAP3K70.59161284
87RET0.58597845
88AKT30.58553984
89JAK10.58247678
90RPS6KA20.55891615
91PRPF4B0.55103982
92PRKACB0.54007247
93ERBB30.53674217
94CAMKK10.53451231
95TAOK20.53388409
96NEK60.52918935
97EPHB10.52414128
98STK380.51886636
99HIPK20.51883998
100EIF2AK20.50907646
101CDK50.50564924
102TYRO30.49942856
103PRKCH0.48801440
104DYRK1A0.48231414
105BMX0.47921053
106MAP3K130.47520966
107CAMK2B0.47170594
108NTRK10.46722562
109CAMK2G0.45003190
110RPS6KA30.44786625
111PDPK10.44665054
112PRKD20.44254795
113WNK10.44040378
114CSK0.43286076
115DAPK20.42634500
116PAK60.42577647
117ICK0.42379032
118PAK30.42293104
119SRC0.41341446
120FGFR40.40796465
121MTOR0.40378871
122INSR0.40025608
123MAPK150.39635821
124ABL10.38291587
125SGK20.38056234
126SGK2230.37918332
127SGK4940.37918332
128ADRBK10.36935230
129MAPK30.36503225
130TAOK10.36319963
131MAPKAPK50.35627126
132PTK20.35252362
133ILK0.34722004
134PRKD10.34223860
135PRKCE0.33821851
136RPS6KB10.32887711
137PRKACG0.32042515
138ROCK20.31467498
139MAP2K30.30616862
140PDK10.30599479
141MAPK110.30551619

Predicted pathways (KEGG)

RankGene SetZ-score
1Regulation of lipolysis in adipocytes_Homo sapiens_hsa049233.76319945
2ECM-receptor interaction_Homo sapiens_hsa045123.73467089
3Fatty acid biosynthesis_Homo sapiens_hsa000613.53934683
4Nitrogen metabolism_Homo sapiens_hsa009103.14424963
5PPAR signaling pathway_Homo sapiens_hsa033202.92574135
6Phenylalanine metabolism_Homo sapiens_hsa003602.92439222
7Protein digestion and absorption_Homo sapiens_hsa049742.87759286
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.85852984
9Propanoate metabolism_Homo sapiens_hsa006402.35598955
10Focal adhesion_Homo sapiens_hsa045102.18593570
11Fatty acid metabolism_Homo sapiens_hsa012122.10754649
12Histidine metabolism_Homo sapiens_hsa003402.00994760
13Fatty acid elongation_Homo sapiens_hsa000621.88395514
14Tyrosine metabolism_Homo sapiens_hsa003501.84263279
15Glycerolipid metabolism_Homo sapiens_hsa005611.74600087
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73492251
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.61358646
18Adipocytokine signaling pathway_Homo sapiens_hsa049201.61039342
19Fatty acid degradation_Homo sapiens_hsa000711.54227125
20AMPK signaling pathway_Homo sapiens_hsa041521.41872904
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.37219062
22Tryptophan metabolism_Homo sapiens_hsa003801.28327090
23PI3K-Akt signaling pathway_Homo sapiens_hsa041511.24423828
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.21727579
25Insulin resistance_Homo sapiens_hsa049311.17340968
26Sulfur metabolism_Homo sapiens_hsa009201.17165674
27Malaria_Homo sapiens_hsa051441.14183932
28Proteoglycans in cancer_Homo sapiens_hsa052051.13024531
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11009201
30Longevity regulating pathway - mammal_Homo sapiens_hsa042111.07791054
31TGF-beta signaling pathway_Homo sapiens_hsa043501.07735174
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99981630
33Renin secretion_Homo sapiens_hsa049240.96873886
34Basal cell carcinoma_Homo sapiens_hsa052170.93088678
35beta-Alanine metabolism_Homo sapiens_hsa004100.91498183
36Morphine addiction_Homo sapiens_hsa050320.89082451
37Salivary secretion_Homo sapiens_hsa049700.86192454
38Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85976140
39cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85719035
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85391120
41Dilated cardiomyopathy_Homo sapiens_hsa054140.82349082
42Hippo signaling pathway_Homo sapiens_hsa043900.81919267
43Caffeine metabolism_Homo sapiens_hsa002320.78784774
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.78485092
45Insulin signaling pathway_Homo sapiens_hsa049100.78435850
46Axon guidance_Homo sapiens_hsa043600.77313266
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76043665
48Glioma_Homo sapiens_hsa052140.74479956
49Amoebiasis_Homo sapiens_hsa051460.74025796
50Adherens junction_Homo sapiens_hsa045200.73691762
51Glycerophospholipid metabolism_Homo sapiens_hsa005640.73458250
52Pyruvate metabolism_Homo sapiens_hsa006200.72639685
53Thyroid hormone synthesis_Homo sapiens_hsa049180.71110899
54Glycosaminoglycan degradation_Homo sapiens_hsa005310.71102879
55Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70903903
56Glucagon signaling pathway_Homo sapiens_hsa049220.70065985
57Rap1 signaling pathway_Homo sapiens_hsa040150.69973718
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69598266
59Melanoma_Homo sapiens_hsa052180.69553849
60Dorso-ventral axis formation_Homo sapiens_hsa043200.68667052
61cAMP signaling pathway_Homo sapiens_hsa040240.68278208
62Lysine degradation_Homo sapiens_hsa003100.67490632
63Cocaine addiction_Homo sapiens_hsa050300.66834175
64Melanogenesis_Homo sapiens_hsa049160.66310377
65Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66072469
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65696429
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.64794594
68Small cell lung cancer_Homo sapiens_hsa052220.64503555
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64357333
70Platelet activation_Homo sapiens_hsa046110.63985109
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63042406
72Circadian rhythm_Homo sapiens_hsa047100.62331514
73Starch and sucrose metabolism_Homo sapiens_hsa005000.62150294
74GABAergic synapse_Homo sapiens_hsa047270.61879716
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.61573316
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60573304
77Notch signaling pathway_Homo sapiens_hsa043300.60364602
78Glutamatergic synapse_Homo sapiens_hsa047240.60123543
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59136299
80Peroxisome_Homo sapiens_hsa041460.59135162
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.57362069
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57119472
83Long-term potentiation_Homo sapiens_hsa047200.56821430
84Gastric acid secretion_Homo sapiens_hsa049710.56033246
85Retinol metabolism_Homo sapiens_hsa008300.55158512
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54768678
87Prostate cancer_Homo sapiens_hsa052150.54571072
88Butanoate metabolism_Homo sapiens_hsa006500.54498435
89HIF-1 signaling pathway_Homo sapiens_hsa040660.53718945
90Ovarian steroidogenesis_Homo sapiens_hsa049130.53325256
91Hedgehog signaling pathway_Homo sapiens_hsa043400.53288118
92Fat digestion and absorption_Homo sapiens_hsa049750.53231187
93Carbon metabolism_Homo sapiens_hsa012000.51093028
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.50301356
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49679405
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48713761
97Long-term depression_Homo sapiens_hsa047300.48413644
98Pathways in cancer_Homo sapiens_hsa052000.47932435
99Gap junction_Homo sapiens_hsa045400.47413241
100Estrogen signaling pathway_Homo sapiens_hsa049150.47058645
101Oxytocin signaling pathway_Homo sapiens_hsa049210.46674535
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.45916615
103Sphingolipid metabolism_Homo sapiens_hsa006000.45682381
104Complement and coagulation cascades_Homo sapiens_hsa046100.45586653
105Amphetamine addiction_Homo sapiens_hsa050310.44903918
106Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44347062
107Steroid biosynthesis_Homo sapiens_hsa001000.43920898
108Bladder cancer_Homo sapiens_hsa052190.43647054
109Renin-angiotensin system_Homo sapiens_hsa046140.43204785
110Bile secretion_Homo sapiens_hsa049760.42606734
111ABC transporters_Homo sapiens_hsa020100.42561507
112Vitamin B6 metabolism_Homo sapiens_hsa007500.42327332
113Wnt signaling pathway_Homo sapiens_hsa043100.42150698
114GnRH signaling pathway_Homo sapiens_hsa049120.41297840
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.40803863
116mTOR signaling pathway_Homo sapiens_hsa041500.40770947
117Dopaminergic synapse_Homo sapiens_hsa047280.40225265
118Tight junction_Homo sapiens_hsa045300.39652870
119Arginine and proline metabolism_Homo sapiens_hsa003300.39566961
120Type II diabetes mellitus_Homo sapiens_hsa049300.39460678
121Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38931718
122Renal cell carcinoma_Homo sapiens_hsa052110.38742865
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38654768
124Circadian entrainment_Homo sapiens_hsa047130.38559540
125Ras signaling pathway_Homo sapiens_hsa040140.38487006
126Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38336465
127Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37382700
128Arginine biosynthesis_Homo sapiens_hsa002200.37272745
129Cholinergic synapse_Homo sapiens_hsa047250.36833052
130Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36534418

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