CHRDL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the chordin family of proteins. Chordin family members are secreted proteins that share a cysteine-rich pro-collagen repeat domain and associate with members of the transforming growth factor beta superfamily. In vitro assays demonstrate a direct interaction between the encoded protein and human activin A. This gene is expressed in many tissues including osteoblasts, where it is differentially expressed during differentiation. In addition, its expression is upregulated in human osteoarthritic joint cartilage, suggesting a role in adult cartilage regeneration. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1oligosaccharide biosynthetic process (GO:0009312)9.79095738
2pattern specification involved in kidney development (GO:0061004)7.46689561
3regulation of vascular endothelial growth factor signaling pathway (GO:1900746)6.98714168
4linoleic acid metabolic process (GO:0043651)6.64764013
5regulation of phospholipid biosynthetic process (GO:0071071)6.53624586
6fatty-acyl-CoA biosynthetic process (GO:0046949)6.50460237
7long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)6.42021804
8regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)6.23226142
9acyl-CoA biosynthetic process (GO:0071616)6.21492203
10thioester biosynthetic process (GO:0035384)6.21492203
11phospholipid homeostasis (GO:0055091)6.13826506
12negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)6.13217259
13pyrimidine-containing compound transmembrane transport (GO:0072531)6.11225069
14alpha-linolenic acid metabolic process (GO:0036109)5.75034201
15intestinal absorption (GO:0050892)5.60474063
16lactation (GO:0007595)5.49697355
17regulation of sequestering of triglyceride (GO:0010889)5.26487931
18regulation of penile erection (GO:0060405)5.25350460
19ceramide catabolic process (GO:0046514)5.10089171
20nucleoside transmembrane transport (GO:1901642)5.02481339
21biotin metabolic process (GO:0006768)5.01560391
22negative regulation of protein kinase B signaling (GO:0051898)5.00050524
23mammary gland epithelial cell differentiation (GO:0060644)4.95284054
24long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.87899472
25secretion by tissue (GO:0032941)4.83139968
26positive regulation of osteoblast proliferation (GO:0033690)4.80138660
27mitochondrial calcium ion transport (GO:0006851)4.77021847
28regulation of apoptotic cell clearance (GO:2000425)4.67616840
29carnitine shuttle (GO:0006853)4.63308155
30negative regulation of endothelial cell proliferation (GO:0001937)4.60420768
31ectoderm development (GO:0007398)4.59095451
32nucleoside transport (GO:0015858)4.57618610
33fatty-acyl-CoA metabolic process (GO:0035337)4.49338224
34fatty acid transmembrane transport (GO:1902001)4.46776795
35positive regulation of p38MAPK cascade (GO:1900745)4.39647267
36GDP-mannose metabolic process (GO:0019673)4.32766903
37detection of molecule of bacterial origin (GO:0032490)4.13402844
38regulation of triglyceride biosynthetic process (GO:0010866)4.08720473
39nucleobase catabolic process (GO:0046113)4.06676022
40body fluid secretion (GO:0007589)4.04367198
41N-acetylneuraminate metabolic process (GO:0006054)3.99072818
42tricarboxylic acid metabolic process (GO:0072350)3.94667499
43regulation of apoptotic process involved in morphogenesis (GO:1902337)3.89386086
44positive regulation of reactive oxygen species metabolic process (GO:2000379)3.85209655
45glutathione biosynthetic process (GO:0006750)3.82254329
46regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.80414432
47response to host immune response (GO:0052572)3.73194792
48response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.73194792
49phagocytosis, recognition (GO:0006910)3.73055287
50tooth mineralization (GO:0034505)3.72599108
51negative regulation of epithelial cell differentiation (GO:0030857)3.71132074
52CDP-diacylglycerol biosynthetic process (GO:0016024)3.66995672
53nonribosomal peptide biosynthetic process (GO:0019184)3.65375516
54intestinal cholesterol absorption (GO:0030299)3.60017400
55cellular carbohydrate biosynthetic process (GO:0034637)3.59902347
56acetyl-CoA metabolic process (GO:0006084)3.58618651
57triglyceride biosynthetic process (GO:0019432)3.56202034
58O-glycan processing (GO:0016266)3.52077435
59nucleotide-sugar biosynthetic process (GO:0009226)3.50690849
60regulation of triglyceride metabolic process (GO:0090207)3.49550831
61positive regulation of triglyceride metabolic process (GO:0090208)3.48277905
62acylglycerol biosynthetic process (GO:0046463)3.47098890
63neutral lipid biosynthetic process (GO:0046460)3.47098890
64response to phenylpropanoid (GO:0080184)3.45800018
65long-chain fatty acid transport (GO:0015909)3.42782562
66positive regulation of triglyceride biosynthetic process (GO:0010867)3.41525922
67temperature homeostasis (GO:0001659)3.39527558
68exocrine pancreas development (GO:0031017)3.38667918
69copper ion transport (GO:0006825)3.37534259
70response to host (GO:0075136)3.36966598
71response to host defenses (GO:0052200)3.36966598
72response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.36966598
73CDP-diacylglycerol metabolic process (GO:0046341)3.36242118
74carnitine transmembrane transport (GO:1902603)3.35640696
75positive regulation of toll-like receptor signaling pathway (GO:0034123)3.31509140
76oligosaccharide metabolic process (GO:0009311)3.29303558
77regulation of fatty acid oxidation (GO:0046320)3.29119665
78folic acid transport (GO:0015884)3.26770179
79I-kappaB phosphorylation (GO:0007252)3.26028992
80positive regulation of macrophage cytokine production (GO:0060907)3.25771408
81regulation of execution phase of apoptosis (GO:1900117)3.24766507
82positive regulation of chemokine secretion (GO:0090197)3.24664160
83mitochondrion distribution (GO:0048311)3.23490472
84sialylation (GO:0097503)3.20279161
85lipid storage (GO:0019915)3.18276962
86negative regulation of execution phase of apoptosis (GO:1900118)3.17588119
87coenzyme A biosynthetic process (GO:0015937)3.16491341
88negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)3.14181390
89cholesterol catabolic process (GO:0006707)3.12147955
90sterol catabolic process (GO:0016127)3.12147955
91segment specification (GO:0007379)3.11793510
92galactose metabolic process (GO:0006012)3.11524689
93fatty acid transport (GO:0015908)3.11502096
94regulation of heat generation (GO:0031650)3.10515018
95zinc ion transport (GO:0006829)3.09278304
96branched-chain amino acid metabolic process (GO:0009081)3.08851916
97carnitine transport (GO:0015879)3.04465119
98amino-acid betaine transport (GO:0015838)3.04465119
99sphingolipid catabolic process (GO:0030149)3.03157455
100branched-chain amino acid catabolic process (GO:0009083)3.01156429
101embryonic process involved in female pregnancy (GO:0060136)3.00563993
102regulation of lipid storage (GO:0010883)2.98303224
103regulation of cholesterol storage (GO:0010885)2.96832568
104purine nucleobase metabolic process (GO:0006144)2.96504219
105negative regulation of keratinocyte proliferation (GO:0010839)2.96188757
106regulation of p38MAPK cascade (GO:1900744)2.93492249
107short-chain fatty acid metabolic process (GO:0046459)2.92273486
108regulation of fever generation (GO:0031620)2.92194802
109valine metabolic process (GO:0006573)2.91481123
110transcytosis (GO:0045056)2.90216340
111positive regulation of heat generation (GO:0031652)2.89294424
112positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.88979581
113proximal/distal pattern formation (GO:0009954)2.87783727
114negative regulation of systemic arterial blood pressure (GO:0003085)2.87095351
115steroid catabolic process (GO:0006706)2.86353354
116regulation of chemokine secretion (GO:0090196)2.85229245
117regulation of clathrin-mediated endocytosis (GO:2000369)2.78899712
118negative regulation of leukocyte migration (GO:0002686)2.76280316
119positive regulation of lipid storage (GO:0010884)2.75660700
120negative regulation of complement activation (GO:0045916)2.75472711
121response to histamine (GO:0034776)2.74548286
122behavioral response to cocaine (GO:0048148)2.71841906
123regulation of vasculogenesis (GO:2001212)2.71575930
124membrane lipid catabolic process (GO:0046466)2.71352997
125angiogenesis involved in wound healing (GO:0060055)2.70142392
126intracellular lipid transport (GO:0032365)2.68806525
127short-term memory (GO:0007614)2.67681992
128detection of external biotic stimulus (GO:0098581)2.67304957
129peptide biosynthetic process (GO:0043043)2.65251983
130COPI coating of Golgi vesicle (GO:0048205)2.64800016
131Golgi transport vesicle coating (GO:0048200)2.64800016
132regulation of macrophage cytokine production (GO:0010935)2.63257627
133regulation of endothelial cell differentiation (GO:0045601)2.61564414
134negative regulation of fatty acid transport (GO:2000192)2.60761069
135negative regulation of transcription by competitive promoter binding (GO:0010944)2.60212946
136response to hydroperoxide (GO:0033194)2.59921766
137nucleoside diphosphate biosynthetic process (GO:0009133)2.58943223
138positive regulation of tissue remodeling (GO:0034105)2.57728033
139positive regulation of growth hormone secretion (GO:0060124)2.57579793
140ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.57441365
141nucleoside bisphosphate biosynthetic process (GO:0033866)2.57441365
142purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.57441365
143early endosome to late endosome transport (GO:0045022)2.56600270
144negative regulation of protein activation cascade (GO:2000258)2.56460749
145protein O-linked glycosylation (GO:0006493)2.55324925
146fatty acid elongation (GO:0030497)2.53979958
147negative regulation of lipid catabolic process (GO:0050995)2.53216430
148negative regulation of leukocyte chemotaxis (GO:0002689)2.52940925
149positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.52916951
150detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.50917844
151muscle cell cellular homeostasis (GO:0046716)2.50852751
152negative regulation of cell fate commitment (GO:0010454)2.48836537
153acrosome assembly (GO:0001675)2.47747837
154ethanol oxidation (GO:0006069)2.45782172
155opsonization (GO:0008228)2.44715943
156regulation of acrosome reaction (GO:0060046)2.43972796
157coenzyme A metabolic process (GO:0015936)2.42292314
158digestive system process (GO:0022600)2.41203885

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse4.98621484
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.10809921
3ESR1_21235772_ChIP-Seq_MCF-7_Human3.34074845
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.12580678
5CLOCK_20551151_ChIP-Seq_293T_Human2.97804433
6GBX2_23144817_ChIP-Seq_PC3_Human2.93337057
7AR_21572438_ChIP-Seq_LNCaP_Human2.88026156
8CDX2_19796622_ChIP-Seq_MESCs_Mouse2.73844215
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.68646566
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.67787762
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.62371147
12EZH2_22144423_ChIP-Seq_EOC_Human2.50401932
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.11981427
14TBX20_22328084_ChIP-Seq_HEART_Mouse2.11034934
15TBX20_22080862_ChIP-Seq_HEART_Mouse2.11034934
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.10483351
17LXR_22158963_ChIP-Seq_LIVER_Mouse2.06268417
18* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.98482426
19SRY_22984422_ChIP-ChIP_TESTIS_Rat1.98374367
20EGR1_23403033_ChIP-Seq_LIVER_Mouse1.97319390
21RXR_22158963_ChIP-Seq_LIVER_Mouse1.95113744
22ZNF217_24962896_ChIP-Seq_MCF-7_Human1.94189528
23ESR1_15608294_ChIP-ChIP_MCF-7_Human1.92507477
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.86595760
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.84777720
26SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.81896294
27* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.70544649
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.63559222
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63217176
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.60386407
31FLI1_21867929_ChIP-Seq_CD8_Mouse1.58779479
32EP300_21415370_ChIP-Seq_HL-1_Mouse1.58761550
33TP53_18474530_ChIP-ChIP_U2OS_Human1.56568799
34* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.56214608
35PPARA_22158963_ChIP-Seq_LIVER_Mouse1.51727688
36* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.48787073
37* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.47752477
38NR3C1_21868756_ChIP-Seq_MCF10A_Human1.46950295
39RXR_22108803_ChIP-Seq_LS180_Human1.44752406
40SOX9_24532713_ChIP-Seq_HFSC_Mouse1.44508441
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44432021
42* AR_25329375_ChIP-Seq_VCAP_Human1.42366305
43NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.42130652
44CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.38971694
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38568144
46AHR_22903824_ChIP-Seq_MCF-7_Human1.37760320
47NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37523028
48* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.37228660
49ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36903846
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36575800
51PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36473071
52NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35461045
53NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35461045
54FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34507399
55DROSHA_22980978_ChIP-Seq_HELA_Human1.32965564
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.32158427
57JARID2_20075857_ChIP-Seq_MESCs_Mouse1.31818781
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31445173
59EZH2_18974828_ChIP-Seq_MESCs_Mouse1.30722363
60RNF2_18974828_ChIP-Seq_MESCs_Mouse1.30722363
61ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.30637046
62TP53_16413492_ChIP-PET_HCT116_Human1.30380422
63ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.26114312
64STAT1_20625510_ChIP-Seq_HELA_Human1.24299967
65ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23286842
66FOXA1_25552417_ChIP-Seq_VCAP_Human1.22867655
67TCF3_18692474_ChIP-Seq_MEFs_Mouse1.22655641
68TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22617027
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22254761
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21861493
71* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.21595247
72FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.20946665
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.20761610
74EED_16625203_ChIP-ChIP_MESCs_Mouse1.20706046
75P300_19829295_ChIP-Seq_ESCs_Human1.20660309
76SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.20058351
77CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19809403
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18621057
79PU.1_20513432_ChIP-Seq_Bcells_Mouse1.18397284
80NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17929362
81RACK7_27058665_Chip-Seq_MCF-7_Human1.15682189
82TP63_17297297_ChIP-ChIP_HaCaT_Human1.15483186
83Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.15437970
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14935021
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.14579009
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13719835
87SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13519847
88SMAD4_21799915_ChIP-Seq_A2780_Human1.13452508
89ERG_21242973_ChIP-ChIP_JURKAT_Human1.12714931
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12018708
91RARG_19884340_ChIP-ChIP_MEFs_Mouse1.11878429
92SOX2_20726797_ChIP-Seq_SW620_Human1.08642407
93TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08334099
94EZH2_27294783_Chip-Seq_ESCs_Mouse1.08101134
95RUNX1_27457419_Chip-Seq_LIVER_Mouse1.07849963
96CJUN_26792858_Chip-Seq_BT549_Human1.07804682
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07496142
98PPAR_26484153_Chip-Seq_NCI-H1993_Human1.06369300
99CMYC_18555785_Chip-Seq_ESCs_Mouse1.06307532
100MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06050678
101KLF5_25053715_ChIP-Seq_YYC3_Human1.05723947
102SMC4_20622854_ChIP-Seq_HELA_Human1.05662494
103VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04684968
104LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04298685
105SMAD3_21741376_ChIP-Seq_HESCs_Human1.03955691
106EZH2_27304074_Chip-Seq_ESCs_Mouse1.03762663
107* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03193805
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03186607
109WDR5_24793694_ChIP-Seq_LNCAP_Human1.03131305
110EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03104863
111JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.03081782
112SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02870648
113BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02461235
114E2F1_18555785_Chip-Seq_ESCs_Mouse1.02286565
115UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02250891
116BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02182133
117CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01889372
118SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99858960
119HTT_18923047_ChIP-ChIP_STHdh_Human0.99707973
120FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99655708
121RNF2_27304074_Chip-Seq_ESCs_Mouse0.99528901
122TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98839053
123TRIM28_21343339_ChIP-Seq_HEK293_Human0.98357767
124PRDM14_20953172_ChIP-Seq_ESCs_Human0.97697072
125SMAD_19615063_ChIP-ChIP_OVARY_Human0.96585353
126PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96133195
127PU_27001747_Chip-Seq_BMDM_Mouse0.95516900
128STAT1_17558387_ChIP-Seq_HELA_Human0.95159675
129TCF4_23295773_ChIP-Seq_U87_Human0.94935522
130GATA4_25053715_ChIP-Seq_YYC3_Human0.94691799
131ESR1_20079471_ChIP-ChIP_T-47D_Human0.94070497
132STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93919672
133* CTCF_26484167_Chip-Seq_Bcells_Mouse0.92267528
134IRF8_22096565_ChIP-ChIP_GC-B_Human0.91962375
135YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91790323
136TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91468220
137AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91301405
138TCF4_22108803_ChIP-Seq_LS180_Human0.91182527
139SA1_27219007_Chip-Seq_ERYTHROID_Human0.91002882
140MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90735649
141STAT3_18555785_Chip-Seq_ESCs_Mouse0.90247492
142PU1_27457419_Chip-Seq_LIVER_Mouse0.89689773
143CBP_21632823_ChIP-Seq_H3396_Human0.89511718
144PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88902145
145TP63_23658742_ChIP-Seq_EP156T_Human0.88707519
146* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88544514
147SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88204665
148PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87976648
149SOX2_18555785_Chip-Seq_ESCs_Mouse0.87853613
150BRD4_27068464_Chip-Seq_AML-cells_Mouse0.87521367
151FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.85467629
152LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.82607684
153CBX2_22325352_ChIP-Seq_293T-Rex_Human0.80573355
154KAP1_22055183_ChIP-Seq_ESCs_Mouse0.80137798
155GATA1_22383799_ChIP-Seq_G1ME_Mouse0.79672692
156EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.79116516
157ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.78096294
158RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.77983094
159FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77011643
160GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.75377758
161SOX17_20123909_ChIP-Seq_XEN_Mouse0.74857774
162CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.74747976
163CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74672052
164LXR_22292898_ChIP-Seq_THP-1_Human0.73669053
165RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.72933888
166RAD21_21589869_ChIP-Seq_MESCs_Mouse0.72803937
167MYC_27129775_Chip-Seq_CORNEA_Mouse0.72330282
168SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.71998795
169RBPJ_21746931_ChIP-Seq_IB4_Human0.71878922

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.81140846
2MP0005083_abnormal_biliary_tract4.36301717
3MP0010234_abnormal_vibrissa_follicle4.21339477
4MP0003303_peritoneal_inflammation3.71793336
5MP0002254_reproductive_system_inflammat3.70963474
6MP0000627_abnormal_mammary_gland3.25927137
7MP0001873_stomach_inflammation3.04536583
8MP0005171_absent_coat_pigmentation2.55150902
9MP0001664_abnormal_digestion2.29838526
10MP0004130_abnormal_muscle_cell2.23261842
11MP0004147_increased_porphyrin_level2.22528001
12MP0004019_abnormal_vitamin_homeostasis2.19728008
13MP0001666_abnormal_nutrient_absorption2.13171776
14MP0001881_abnormal_mammary_gland11.3121862
15MP0003718_maternal_effect1.98906507
16MP0005670_abnormal_white_adipose1.80623009
17MP0005085_abnormal_gallbladder_physiolo1.75906138
18MP0003011_delayed_dark_adaptation1.61964659
19MP0004043_abnormal_pH_regulation1.53800345
20MP0001663_abnormal_digestive_system1.44005559
21MP0002098_abnormal_vibrissa_morphology1.38768329
22MP0005410_abnormal_fertilization1.37609582
23MP0003300_gastrointestinal_ulcer1.36665528
24MP0003705_abnormal_hypodermis_morpholog1.34349004
25MP0002796_impaired_skin_barrier1.30795702
26MP0008004_abnormal_stomach_pH1.29929990
27MP0006292_abnormal_olfactory_placode1.21422646
28MP0002118_abnormal_lipid_homeostasis1.16188135
29MP0005636_abnormal_mineral_homeostasis1.12454708
30MP0000678_abnormal_parathyroid_gland1.10791206
31MP0005381_digestive/alimentary_phenotyp1.08841499
32MP0005395_other_phenotype1.08119467
33MP0002234_abnormal_pharynx_morphology1.07085418
34MP0003690_abnormal_glial_cell1.05068803
35MP0009384_cardiac_valve_regurgitation1.03330725
36MP0010386_abnormal_urinary_bladder1.03167684
37MP0005058_abnormal_lysosome_morphology1.02928194
38MP0001177_atelectasis0.99899690
39MP0002139_abnormal_hepatobiliary_system0.95975634
40MP0004858_abnormal_nervous_system0.95356815
41MP0003787_abnormal_imprinting0.93257266
42MP0010678_abnormal_skin_adnexa0.92843252
43MP0005645_abnormal_hypothalamus_physiol0.92074545
44MP0001849_ear_inflammation0.91989153
45MP0005646_abnormal_pituitary_gland0.90134844
46MP0005647_abnormal_sex_gland0.89924368
47MP0005595_abnormal_vascular_smooth0.89668580
48MP0009764_decreased_sensitivity_to0.87699552
49MP0003936_abnormal_reproductive_system0.86303137
50MP0005360_urolithiasis0.85865356
51MP0005248_abnormal_Harderian_gland0.85706197
52MP0005666_abnormal_adipose_tissue0.83523322
53MP0005332_abnormal_amino_acid0.82658653
54MP0000377_abnormal_hair_follicle0.82190940
55MP0008438_abnormal_cutaneous_collagen0.81463102
56MP0004272_abnormal_basement_membrane0.79807227
57MP0005365_abnormal_bile_salt0.79480367
58MP0003283_abnormal_digestive_organ0.78967327
59MP0003075_altered_response_to0.77093587
60MP0004782_abnormal_surfactant_physiolog0.75113498
61MP0005334_abnormal_fat_pad0.74797821
62MP0003959_abnormal_lean_body0.72667225
63MP0008260_abnormal_autophagy0.72343906
64MP0009379_abnormal_foot_pigmentation0.72277847
65MP0001188_hyperpigmentation0.71210537
66MP0009643_abnormal_urine_homeostasis0.70896849
67MP0003880_abnormal_central_pattern0.69929750
68MP0003950_abnormal_plasma_membrane0.69904770
69MP0001544_abnormal_cardiovascular_syste0.69649900
70MP0005385_cardiovascular_system_phenoty0.69649900
71MP0002971_abnormal_brown_adipose0.69499630
72MP0000759_abnormal_skeletal_muscle0.68280274
73MP0000639_abnormal_adrenal_gland0.68081043
74MP0003868_abnormal_feces_composition0.67784096
75MP0000003_abnormal_adipose_tissue0.67635231
76MP0002736_abnormal_nociception_after0.64641493
77MP0005220_abnormal_exocrine_pancreas0.63982353
78MP0004215_abnormal_myocardial_fiber0.62948711
79MP0003938_abnormal_ear_development0.62548578
80MP0009765_abnormal_xenobiotic_induced0.62135749
81MP0005451_abnormal_body_composition0.62077200
82MP0004264_abnormal_extraembryonic_tissu0.61869917
83MP0003566_abnormal_cell_adhesion0.61677746
84MP0003195_calcinosis0.61121687
85MP0001984_abnormal_olfaction0.60650803
86MP0002277_abnormal_respiratory_mucosa0.60438918
87MP0005375_adipose_tissue_phenotype0.59379505
88MP0002896_abnormal_bone_mineralization0.57693775
89MP0002009_preneoplasia0.57508551
90MP0010329_abnormal_lipoprotein_level0.57376719
91MP0000613_abnormal_salivary_gland0.57216790
92MP0005584_abnormal_enzyme/coenzyme_acti0.56214893
93MP0000566_synostosis0.55976285
94MP0003656_abnormal_erythrocyte_physiolo0.55912829
95MP0001765_abnormal_ion_homeostasis0.54738664
96MP0002282_abnormal_trachea_morphology0.54262482
97MP0000579_abnormal_nail_morphology0.54227721
98MP0005501_abnormal_skin_physiology0.54152911
99MP0002089_abnormal_postnatal_growth/wei0.53872107
100MP0001502_abnormal_circadian_rhythm0.53573852
101MP0005165_increased_susceptibility_to0.53465604
102MP0000470_abnormal_stomach_morphology0.53268052
103MP0002168_other_aberrant_phenotype0.53157957
104MP0001958_emphysema0.52191118
105MP0001501_abnormal_sleep_pattern0.51699190
106MP0000631_abnormal_neuroendocrine_gland0.50613401
107MP0000490_abnormal_crypts_of0.50581431
108MP0000467_abnormal_esophagus_morphology0.50376094
109MP0001727_abnormal_embryo_implantation0.49192214
110MP0002876_abnormal_thyroid_physiology0.48930523
111MP0003948_abnormal_gas_homeostasis0.47786679
112MP0003448_altered_tumor_morphology0.47730540
113MP0003045_fibrosis0.47612793
114MP0002998_abnormal_bone_remodeling0.47210157
115MP0002970_abnormal_white_adipose0.46563498
116MP0005448_abnormal_energy_balance0.45018685
117MP0005535_abnormal_body_temperature0.44984495
118MP0003953_abnormal_hormone_level0.44793391
119MP0005452_abnormal_adipose_tissue0.43122191
120MP0000858_altered_metastatic_potential0.42932268
121MP0000681_abnormal_thyroid_gland0.42510098
122MP0005386_behavior/neurological_phenoty0.42437457
123MP0004924_abnormal_behavior0.42437457
124MP0000163_abnormal_cartilage_morphology0.42272676
125MP0004133_heterotaxia0.41899566
126MP0002693_abnormal_pancreas_physiology0.41641172
127MP0002078_abnormal_glucose_homeostasis0.41475533
128MP0001756_abnormal_urination0.41157776
129MP0009642_abnormal_blood_homeostasis0.38432444
130MP0009763_increased_sensitivity_to0.36645409
131MP0001542_abnormal_bone_strength0.36220157
132MP0000343_altered_response_to0.35967512
133MP0002135_abnormal_kidney_morphology0.35702700
134MP0002972_abnormal_cardiac_muscle0.34568515
135MP0010368_abnormal_lymphatic_system0.33644774
136MP0010352_gastrointestinal_tract_polyps0.33332729
137MP0008770_decreased_survivor_rate0.32439257
138MP0005319_abnormal_enzyme/_coenzyme0.32399273
139MP0002148_abnormal_hypersensitivity_rea0.31855319
140MP0000751_myopathy0.31491429
141MP0005023_abnormal_wound_healing0.30357638
142MP0008874_decreased_physiological_sensi0.29264230
143MP0000609_abnormal_liver_physiology0.28442358
144MP0009785_altered_susceptibility_to0.28358440
145MP0000230_abnormal_systemic_arterial0.27864664
146MP0000538_abnormal_urinary_bladder0.27860790
147MP0003638_abnormal_response/metabolism_0.27560816
148MP0000749_muscle_degeneration0.26049970
149MP0005620_abnormal_muscle_contractility0.25581560
150MP0000371_diluted_coat_color0.22881534
151MP0000762_abnormal_tongue_morphology0.21130311
152MP0003646_muscle_fatigue0.21053372
153MP0003699_abnormal_female_reproductive0.20602027
154MP0008775_abnormal_heart_ventricle0.20129068

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)6.43422888
2Tubulointerstitial nephritis (HP:0001970)6.34319976
3Decreased circulating renin level (HP:0003351)6.18145488
4Amelogenesis imperfecta (HP:0000705)5.27454314
5Abnormality of purine metabolism (HP:0004352)4.94942749
6Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.44669570
7Gout (HP:0001997)4.43132183
8Axonal loss (HP:0003447)4.39818444
9Abnormal auditory evoked potentials (HP:0006958)4.39145259
10Metaphyseal dysplasia (HP:0100255)4.23102604
11Nephrolithiasis (HP:0000787)3.99659486
12Hyperlipoproteinemia (HP:0010980)3.99614545
13Congenital ichthyosiform erythroderma (HP:0007431)3.88727281
14Hypokalemic alkalosis (HP:0001949)3.87260127
15Turricephaly (HP:0000262)3.83998786
16Hyperkalemia (HP:0002153)3.82745653
17Tubulointerstitial fibrosis (HP:0005576)3.80746538
18Aplasia of the phalanges of the hand (HP:0009802)3.74096817
19Aplasia involving bones of the extremities (HP:0009825)3.74096817
20Aplasia involving bones of the upper limbs (HP:0009823)3.74096817
21Hydronephrosis (HP:0000126)3.70520303
22Stridor (HP:0010307)3.57132929
23Skin nodule (HP:0200036)3.50637477
24Ectropion (HP:0000656)3.50561706
25Abnormality of calcium-phosphate metabolism (HP:0100530)3.30693627
26Protruding tongue (HP:0010808)3.30681652
27Epiphyseal dysplasia (HP:0002656)3.27787551
28Hyperaldosteronism (HP:0000859)3.27500788
29Epidermoid cyst (HP:0200040)3.26068075
30Chronic bronchitis (HP:0004469)3.24308708
31Myocardial infarction (HP:0001658)3.19993666
32Curly hair (HP:0002212)3.19371558
33Tubular atrophy (HP:0000092)3.13729367
34Abnormality of the dental pulp (HP:0006479)3.10311212
35Hypotension (HP:0002615)3.07694671
36Glomerulonephritis (HP:0000099)3.06843385
37Tubulointerstitial abnormality (HP:0001969)2.98846351
38Xanthomatosis (HP:0000991)2.98500897
39Abnormality of renal excretion (HP:0011036)2.93946706
40Abnormality of nucleobase metabolism (HP:0010932)2.92771063
41Hypoplasia of the iris (HP:0007676)2.87027265
42Hyponatremia (HP:0002902)2.85017531
43Flat acetabular roof (HP:0003180)2.84975009
44Hypoplastic nipples (HP:0002557)2.81750704
45Thin bony cortex (HP:0002753)2.78641334
46Metaphyseal irregularity (HP:0003025)2.78117763
47Hyperglycinuria (HP:0003108)2.75396028
48Blue irides (HP:0000635)2.73479240
49Abnormality of renin-angiotensin system (HP:0000847)2.71126987
50Nausea (HP:0002018)2.71059438
51Abnormality of chloride homeostasis (HP:0011422)2.68475972
52Complement deficiency (HP:0004431)2.67317775
53Systemic lupus erythematosus (HP:0002725)2.67034907
54Abnormal tarsal ossification (HP:0008369)2.66131625
55Subcapsular cataract (HP:0000523)2.65258600
56Asymmetric septal hypertrophy (HP:0001670)2.63681892
57Abnormality of renal resorption (HP:0011038)2.58228363
58Pili torti (HP:0003777)2.57738181
59Back pain (HP:0003418)2.56090734
60Overgrowth (HP:0001548)2.56031836
61White forelock (HP:0002211)2.55230113
62Severe muscular hypotonia (HP:0006829)2.49939594
63Protuberant abdomen (HP:0001538)2.47710017
64Onycholysis (HP:0001806)2.46959300
65Nephritis (HP:0000123)2.44808989
66Delayed epiphyseal ossification (HP:0002663)2.41369585
67Hyperglycinemia (HP:0002154)2.41066306
68Premature skin wrinkling (HP:0100678)2.40432064
69Muscle fiber splitting (HP:0003555)2.40076873
70Enlarged epiphyses (HP:0010580)2.39135592
71Symptomatic seizures (HP:0011145)2.36602186
72Premature loss of primary teeth (HP:0006323)2.35710333
73Cortical visual impairment (HP:0100704)2.35408925
74Abnormality of sodium homeostasis (HP:0010931)2.34351120
75Hypoplasia of dental enamel (HP:0006297)2.31658457
76Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.30423872
77Hypothermia (HP:0002045)2.24449225
78Rickets (HP:0002748)2.23246078
79Patchy hypopigmentation of hair (HP:0011365)2.21988106
80Hyperuricemia (HP:0002149)2.21219602
81Increased purine levels (HP:0004368)2.21219602
82Widely patent fontanelles and sutures (HP:0004492)2.19844164
83Glomerulosclerosis (HP:0000096)2.18847018
84Bell-shaped thorax (HP:0001591)2.15489296
85Intrahepatic cholestasis (HP:0001406)2.14931593
86Adrenal overactivity (HP:0002717)2.14600660
87Azoospermia (HP:0000027)2.10120752
88Metabolic acidosis (HP:0001942)2.10066802
89Hypercholesterolemia (HP:0003124)2.08305558
90Tetraparesis (HP:0002273)2.06325311
91Alkalosis (HP:0001948)2.04654422
92Optic nerve hypoplasia (HP:0000609)2.03925346
93Split foot (HP:0001839)2.02324159
94Abnormality of aromatic amino acid family metabolism (HP:0004338)2.02015985
95Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.99866887
96Neurodegeneration (HP:0002180)1.99720071
97Loss of speech (HP:0002371)1.98959299
98Hyperparathyroidism (HP:0000843)1.98434781
99Ventricular fibrillation (HP:0001663)1.98407858
100Abnormality of fatty-acid metabolism (HP:0004359)1.97899205
101Abnormality of complement system (HP:0005339)1.97358207
102Abnormality of serine family amino acid metabolism (HP:0010894)1.96166244
103Abnormality of glycine metabolism (HP:0010895)1.96166244
104Abnormality of the renal cortex (HP:0011035)1.95219510
105Syncope (HP:0001279)1.94883902
106Spastic tetraparesis (HP:0001285)1.94485030
107Elevated alkaline phosphatase (HP:0003155)1.93742623
108Hypophosphatemic rickets (HP:0004912)1.93308410
109Exotropia (HP:0000577)1.93211497
110Abnormal epiphyseal ossification (HP:0010656)1.89854442
111Hypokalemia (HP:0002900)1.89760531
112Hypophosphatemia (HP:0002148)1.88450067
113Stomach cancer (HP:0012126)1.87386881
114Abnormality of proline metabolism (HP:0010907)1.87242456
115Hydroxyprolinuria (HP:0003080)1.87242456
116Reduced antithrombin III activity (HP:0001976)1.84706898
117Genu varum (HP:0002970)1.83790827
118Vacuolated lymphocytes (HP:0001922)1.83218410
119Neonatal hypoglycemia (HP:0001998)1.81776068
120Cerebellar dysplasia (HP:0007033)1.81473464
121Gingival overgrowth (HP:0000212)1.81240358
122Clumsiness (HP:0002312)1.79669590
123Aortic aneurysm (HP:0004942)1.79271004
124Hyperphosphatemia (HP:0002905)1.79190878
125Increased number of teeth (HP:0011069)1.79136281
126Congenital sensorineural hearing impairment (HP:0008527)1.78151276
127Abnormality of vision evoked potentials (HP:0000649)1.77935007
128Morphological abnormality of the inner ear (HP:0011390)1.77862004
129Abnormality of the costochondral junction (HP:0000919)1.77205943
130Type II lissencephaly (HP:0007260)1.76648660
131Lymphangioma (HP:0100764)1.76639476
132Congenital glaucoma (HP:0001087)1.76250982
133Supernumerary nipples (HP:0002558)1.76055210
134Abnormality of transition element cation homeostasis (HP:0011030)1.75735859
135Hypohidrosis (HP:0000966)1.75456387
136Abnormality of dental color (HP:0011073)1.74928326
137Purpura (HP:0000979)1.74923861
138Sudden death (HP:0001699)1.74433008
139Abnormal enzyme/coenzyme activity (HP:0012379)1.74411746
140Right ventricular cardiomyopathy (HP:0011663)1.73080045
141Abdominal distention (HP:0003270)1.71098688
142Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70997388
143Ketosis (HP:0001946)1.70691836
144Bone cyst (HP:0012062)1.69693826
145Pancreatitis (HP:0001733)1.69485632
146Renal salt wasting (HP:0000127)1.68784077
147Abnormality of alkaline phosphatase activity (HP:0004379)1.68560341
148Polar cataract (HP:0010696)1.67347739
149Abnormality of the periventricular white matter (HP:0002518)1.67177153
150Prolonged QT interval (HP:0001657)1.66096381
151Hepatosplenomegaly (HP:0001433)1.65895031
152Hypoglycemic seizures (HP:0002173)1.65874785
153Rimmed vacuoles (HP:0003805)1.65238493
154Thoracic kyphosis (HP:0002942)1.64531665
155Aplasia/Hypoplasia of the tibia (HP:0005772)1.63939297
156Type I transferrin isoform profile (HP:0003642)1.63805966
157Retinal atrophy (HP:0001105)1.63716017
158Buphthalmos (HP:0000557)1.63576917
159Broad metatarsal (HP:0001783)1.61952349
160Mixed hearing impairment (HP:0000410)1.61595522
161Vascular calcification (HP:0004934)1.61229128
162Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.61109283
163Rhabdomyolysis (HP:0003201)1.60902238
164Foot dorsiflexor weakness (HP:0009027)1.59656230
165Primary adrenal insufficiency (HP:0008207)1.59528186
166Abnormal glycosylation (HP:0012345)1.59412577
167Abnormal protein N-linked glycosylation (HP:0012347)1.59412577
168Optic neuritis (HP:0100653)1.58381622
169Retrobulbar optic neuritis (HP:0100654)1.58381622
170Orchitis (HP:0100796)1.56774931

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK7.21093008
2SIK14.40081909
3NTRK34.36024266
4CAMK1D3.70079632
5PKN23.14649059
6CAMK1G2.82231143
7ARAF2.23552580
8PIK3CG2.20810416
9TRIB32.17439553
10TESK12.09356223
11LATS12.09298399
12EEF2K2.05970407
13MAP3K62.03929189
14IRAK32.02877372
15EPHA42.00813225
16BCKDK1.98709163
17MAP3K141.95233705
18NLK1.87680130
19JAK31.71955394
20MAPK131.67321703
21LMTK21.62330567
22MAP3K71.47663889
23PTK61.44699725
24PDK41.43119736
25PDK31.43119736
26STK38L1.40425472
27ERN11.36019936
28TRPM71.33546522
29EPHA31.31070586
30PDK21.30725270
31STK381.30035338
32LRRK21.24972039
33MAP3K131.24771404
34PRPF4B1.22747894
35PIK3CA1.21401633
36MUSK1.21023370
37ICK1.19260887
38PINK11.17369202
39KSR21.15635494
40DAPK21.14818317
41MAP3K91.14337315
42EIF2AK21.14188940
43PDGFRB1.14119759
44FGFR41.12722084
45MOS1.10221252
46DDR21.05621944
47PRKAA21.04628570
48STK391.04511966
49MTOR1.04202735
50NME21.02971511
51FER1.02172670
52ZAP700.96159381
53BRAF0.91107169
54TAOK20.89122412
55MAPKAPK30.88889556
56MAPK120.87789064
57LIMK10.86859319
58EPHB10.86593597
59EIF2AK30.85628830
60WNK40.83972481
61CAMK2D0.83397269
62MAP3K10.82852736
63CAMK10.80435890
64TTN0.79461571
65TAOK10.78156422
66CHUK0.77299094
67TBK10.77104457
68CASK0.76690771
69IRAK10.74461497
70SGK2230.74453148
71SGK4940.74453148
72PRKG20.70971404
73MAP2K70.70152677
74JAK10.69066233
75PDPK10.68634956
76TESK20.67255349
77PRKAA10.66540876
78DMPK0.66192893
79IKBKE0.65769054
80CSNK2A20.64431396
81WNK10.64347100
82BMPR20.62519833
83BMX0.61197409
84TGFBR20.58892798
85STK240.58009602
86SGK30.57203560
87CAMK2B0.56566648
88FRK0.55245871
89ZAK0.52613442
90FGFR30.52461512
91SCYL20.51754929
92ILK0.51502798
93NUAK10.51013757
94CAMKK10.50810590
95CSNK1A1L0.50693523
96RPS6KL10.50683038
97RPS6KC10.50683038
98PDK10.48946385
99RPS6KB10.48243673
100TYK20.47660850
101NEK90.47644544
102ERBB40.47354045
103CSNK1A10.46165595
104PRKCD0.45893151
105MAP2K20.44306467
106RET0.44258084
107INSRR0.43274919
108IRAK40.41827725
109MAPKAPK50.40987851
110RPS6KA60.40513161
111FES0.40259378
112PRKCE0.40028491
113MAP3K50.39899402
114STK30.39864616
115TIE10.38704238
116NEK60.38068111
117CDC42BPA0.37363554
118MARK30.36486790
119RIPK10.35821349
120IGF1R0.34798801
121GSK3A0.34202370
122MAPK110.33626299
123BTK0.33250114
124IRAK20.33059256
125GRK60.32853170
126PRKACG0.32089829
127JAK20.31663315
128FGR0.29840255
129RPS6KA20.29630781
130CSNK1G20.29084218
131CSNK1G10.28235535
132STK160.27284487
133PHKG20.26781714
134PHKG10.26781714
135PIM10.26737498
136NME10.25557292
137SGK20.25123173
138MYLK0.24869287
139PRKCG0.24509776
140PRKD10.23452397
141MAP2K60.22950842
142OBSCN0.21216831
143PTK20.21072362
144SGK10.20948611
145RPS6KB20.20350883
146CAMK2A0.19778171
147CAMK2G0.19728150
148CSNK1D0.19580909

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000619.13437997
2Caffeine metabolism_Homo sapiens_hsa002327.07222143
3Galactose metabolism_Homo sapiens_hsa000522.98701659
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.88908759
5Fatty acid metabolism_Homo sapiens_hsa012122.45258727
6Propanoate metabolism_Homo sapiens_hsa006402.24675634
7Steroid biosynthesis_Homo sapiens_hsa001002.18469922
8Prolactin signaling pathway_Homo sapiens_hsa049172.00768577
9Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.98683596
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.94377740
11Cyanoamino acid metabolism_Homo sapiens_hsa004601.78691199
12Pyruvate metabolism_Homo sapiens_hsa006201.70590768
13Nitrogen metabolism_Homo sapiens_hsa009101.40333778
14PPAR signaling pathway_Homo sapiens_hsa033201.35162071
15N-Glycan biosynthesis_Homo sapiens_hsa005101.34271713
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.08267163
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06255080
18Fat digestion and absorption_Homo sapiens_hsa049751.05694310
19Fatty acid elongation_Homo sapiens_hsa000621.03613921
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00747240
21Pancreatic secretion_Homo sapiens_hsa049720.97885826
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94398695
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89640784
24Protein digestion and absorption_Homo sapiens_hsa049740.87859576
25Folate biosynthesis_Homo sapiens_hsa007900.83986502
26Adipocytokine signaling pathway_Homo sapiens_hsa049200.80179336
27Glycerolipid metabolism_Homo sapiens_hsa005610.79054802
28Vitamin digestion and absorption_Homo sapiens_hsa049770.75937771
29Fatty acid degradation_Homo sapiens_hsa000710.73930315
30Protein export_Homo sapiens_hsa030600.73778891
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72350974
32Taste transduction_Homo sapiens_hsa047420.72087028
33Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71821531
34Peroxisome_Homo sapiens_hsa041460.71187657
35Histidine metabolism_Homo sapiens_hsa003400.70803739
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66739875
37Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66598028
38Nicotine addiction_Homo sapiens_hsa050330.64422508
39Rheumatoid arthritis_Homo sapiens_hsa053230.64024097
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62881268
41Endometrial cancer_Homo sapiens_hsa052130.60385892
42Circadian rhythm_Homo sapiens_hsa047100.59513633
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58951047
44ECM-receptor interaction_Homo sapiens_hsa045120.58622573
45Arginine and proline metabolism_Homo sapiens_hsa003300.57865537
46Mineral absorption_Homo sapiens_hsa049780.56576951
47Primary bile acid biosynthesis_Homo sapiens_hsa001200.52182730
48Lysosome_Homo sapiens_hsa041420.49875254
49ErbB signaling pathway_Homo sapiens_hsa040120.49380365
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48643307
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48192159
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47475381
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45324527
54Acute myeloid leukemia_Homo sapiens_hsa052210.44763343
55Sulfur metabolism_Homo sapiens_hsa009200.43702159
56Fructose and mannose metabolism_Homo sapiens_hsa000510.43470137
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.42954289
58Collecting duct acid secretion_Homo sapiens_hsa049660.42247623
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.42201478
60Starch and sucrose metabolism_Homo sapiens_hsa005000.41780517
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40848901
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40105661
63ABC transporters_Homo sapiens_hsa020100.39877077
64Carbon metabolism_Homo sapiens_hsa012000.39810705
65Pentose phosphate pathway_Homo sapiens_hsa000300.38363049
66Insulin resistance_Homo sapiens_hsa049310.37806972
67AMPK signaling pathway_Homo sapiens_hsa041520.37664411
68Sulfur relay system_Homo sapiens_hsa041220.37518430
69Malaria_Homo sapiens_hsa051440.37410730
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36614484
71Ether lipid metabolism_Homo sapiens_hsa005650.35674485
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35408241
73Calcium signaling pathway_Homo sapiens_hsa040200.33908615
74Arginine biosynthesis_Homo sapiens_hsa002200.32952511
75Basal cell carcinoma_Homo sapiens_hsa052170.32767327
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32598092
77Hepatitis C_Homo sapiens_hsa051600.32362792
78Biosynthesis of amino acids_Homo sapiens_hsa012300.30474323
79Insulin signaling pathway_Homo sapiens_hsa049100.29446573
80Phagosome_Homo sapiens_hsa041450.28106035
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.27905411
82Glutamatergic synapse_Homo sapiens_hsa047240.27529677
83Amoebiasis_Homo sapiens_hsa051460.27456824
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.27354630
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26598649
86Pertussis_Homo sapiens_hsa051330.25580183
87Tuberculosis_Homo sapiens_hsa051520.25219121
88beta-Alanine metabolism_Homo sapiens_hsa004100.25134448
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.23573941
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22340524
91Chronic myeloid leukemia_Homo sapiens_hsa052200.22076704
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.21064205
93Complement and coagulation cascades_Homo sapiens_hsa046100.20988015
94Linoleic acid metabolism_Homo sapiens_hsa005910.20821244
95Glutathione metabolism_Homo sapiens_hsa004800.20442640
96Metabolic pathways_Homo sapiens_hsa011000.20411665
97Legionellosis_Homo sapiens_hsa051340.19857085
98Dorso-ventral axis formation_Homo sapiens_hsa043200.19649722
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.19044391
100Purine metabolism_Homo sapiens_hsa002300.18676932
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18674526
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.18062926
103Glucagon signaling pathway_Homo sapiens_hsa049220.18048391
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.17877339
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17653283
106Butanoate metabolism_Homo sapiens_hsa006500.17547142
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.16952235
108Toxoplasmosis_Homo sapiens_hsa051450.16839487
109Focal adhesion_Homo sapiens_hsa045100.16661999
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15313053
111Synaptic vesicle cycle_Homo sapiens_hsa047210.14765416
112GABAergic synapse_Homo sapiens_hsa047270.14710947
113Arachidonic acid metabolism_Homo sapiens_hsa005900.14301942
114NOD-like receptor signaling pathway_Homo sapiens_hsa046210.14290855
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13950095
116Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.13539804
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.13495920
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13481699
119Pentose and glucuronate interconversions_Homo sapiens_hsa000400.13383848
120Vibrio cholerae infection_Homo sapiens_hsa051100.13244468
121Salivary secretion_Homo sapiens_hsa049700.13083504
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.12500980
123Ovarian steroidogenesis_Homo sapiens_hsa049130.11481150
124Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.11446020
125Tryptophan metabolism_Homo sapiens_hsa003800.10619532
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.08901125
127Staphylococcus aureus infection_Homo sapiens_hsa051500.06490134
128Tight junction_Homo sapiens_hsa045300.05566175
129Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.04915823
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.03072270
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.01579326
132One carbon pool by folate_Homo sapiens_hsa006700.01293247
133Leukocyte transendothelial migration_Homo sapiens_hsa046700.00461279
134Vitamin B6 metabolism_Homo sapiens_hsa007500.00211775
135VEGF signaling pathway_Homo sapiens_hsa04370-0.0542505
136Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.0485521
137Cholinergic synapse_Homo sapiens_hsa04725-0.0426503
138Cysteine and methionine metabolism_Homo sapiens_hsa00270-0.0372056
139Dilated cardiomyopathy_Homo sapiens_hsa05414-0.0361226
140Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261-0.0337963
141Bile secretion_Homo sapiens_hsa04976-0.0310357
142Ascorbate and aldarate metabolism_Homo sapiens_hsa00053-0.0245410
143Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0107019
144Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0079486
145GnRH signaling pathway_Homo sapiens_hsa04912-0.0044638

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