CHRM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.96983251
2positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.44019053
3regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)6.39684967
4regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.34822288
5negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.24173202
6cardiac myofibril assembly (GO:0055003)6.13310226
7endocardial cushion development (GO:0003197)6.05927914
8sarcomere organization (GO:0045214)6.01524518
9negative regulation of potassium ion transmembrane transport (GO:1901380)5.79873535
10regulation of relaxation of muscle (GO:1901077)5.59084374
11tricarboxylic acid cycle (GO:0006099)5.48317633
12cardiac muscle contraction (GO:0060048)5.26631399
13cell migration involved in heart development (GO:0060973)5.25917828
14regulation of cell communication by electrical coupling (GO:0010649)5.23615220
15regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.16799870
16myofibril assembly (GO:0030239)5.16473838
17cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.10196595
18regulation of actin filament-based movement (GO:1903115)5.00656907
19bone trabecula formation (GO:0060346)4.92116643
20regulation of cardioblast differentiation (GO:0051890)4.90736318
21cell communication involved in cardiac conduction (GO:0086065)4.86514744
22cardiac chamber formation (GO:0003207)4.74864981
23ventricular cardiac muscle cell action potential (GO:0086005)4.70458176
24pericardium development (GO:0060039)4.68645047
25atrial septum morphogenesis (GO:0060413)4.64281961
26regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.60873846
27regulation of membrane repolarization (GO:0060306)4.58546115
28sequestering of extracellular ligand from receptor (GO:0035581)4.53718907
29regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.52750065
30cell communication by electrical coupling (GO:0010644)4.45767889
31mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.37149488
32sarcoplasmic reticulum calcium ion transport (GO:0070296)4.35260483
33regulation of acyl-CoA biosynthetic process (GO:0050812)4.33895296
34mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.31714427
35plasma membrane repair (GO:0001778)4.31247372
36outflow tract septum morphogenesis (GO:0003148)4.30898297
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.24330619
38cardiac muscle cell development (GO:0055013)4.20505094
39regulation of sarcomere organization (GO:0060297)4.20371860
40regulation of cardiac muscle cell contraction (GO:0086004)4.18255415
41regulation of striated muscle contraction (GO:0006942)4.16175863
42positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.15803210
43cardiac muscle hypertrophy (GO:0003300)4.14318467
44positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.12956375
45detection of calcium ion (GO:0005513)4.08398642
46regulation of cardiac muscle contraction (GO:0055117)4.06904926
47protein heterotrimerization (GO:0070208)4.02012460
48regulation of the force of heart contraction (GO:0002026)4.01040269
49relaxation of cardiac muscle (GO:0055119)4.00089239
50respiratory electron transport chain (GO:0022904)3.99685802
51atrioventricular valve morphogenesis (GO:0003181)3.98229251
52regulation of cofactor metabolic process (GO:0051193)3.97004009
53regulation of coenzyme metabolic process (GO:0051196)3.97004009
54ATP synthesis coupled proton transport (GO:0015986)3.96055360
55energy coupled proton transport, down electrochemical gradient (GO:0015985)3.96055360
56electron transport chain (GO:0022900)3.94730915
57extracellular matrix assembly (GO:0085029)3.94553182
58striated muscle hypertrophy (GO:0014897)3.93487374
59adult heart development (GO:0007512)3.91492545
60positive regulation of potassium ion transmembrane transport (GO:1901381)3.90965202
61cardiac cell development (GO:0055006)3.90108341
62bundle of His cell to Purkinje myocyte communication (GO:0086069)3.87136202
63positive regulation of cardiac muscle tissue development (GO:0055025)3.85638691
64positive regulation of cardiac muscle cell differentiation (GO:2000727)3.82190995
65cardiac ventricle formation (GO:0003211)3.81512176
66cardiac conduction (GO:0061337)3.79537404
67type B pancreatic cell proliferation (GO:0044342)3.77899151
68cardiac muscle tissue morphogenesis (GO:0055008)3.77725283
69regulation of calcium ion transmembrane transport (GO:1903169)3.77571061
70regulation of calcium ion transmembrane transporter activity (GO:1901019)3.77571061
71striated muscle contraction (GO:0006941)3.77222147
72endocardial cushion morphogenesis (GO:0003203)3.75640118
73venous blood vessel morphogenesis (GO:0048845)3.75517716
74actomyosin structure organization (GO:0031032)3.75306533
75ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.72062561
76collagen fibril organization (GO:0030199)3.69891000
77positive regulation of cardiac muscle cell proliferation (GO:0060045)3.67588666
78carnitine shuttle (GO:0006853)3.67088192
79heart trabecula formation (GO:0060347)3.64810813
80muscle filament sliding (GO:0030049)3.63815052
81actin-myosin filament sliding (GO:0033275)3.63815052
82cardiac muscle cell action potential (GO:0086001)3.62377731
83regulation of heart rate by cardiac conduction (GO:0086091)3.62315894
84cardiac muscle cell action potential involved in contraction (GO:0086002)3.62239568
85negative regulation of potassium ion transport (GO:0043267)3.59001157
86regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.57963970
87regulation of heart rate (GO:0002027)3.57776481
88positive regulation of cation channel activity (GO:2001259)3.57770133
89mesenchymal-epithelial cell signaling (GO:0060638)3.57461987
90kidney mesenchyme development (GO:0072074)3.54913578
91positive regulation of cardiac muscle tissue growth (GO:0055023)3.53761665
92oxygen transport (GO:0015671)3.52865441
93NADH metabolic process (GO:0006734)3.51160046
94negative regulation of hormone biosynthetic process (GO:0032353)3.46885694
95negative regulation of striated muscle cell apoptotic process (GO:0010664)3.43658044
96muscle hypertrophy (GO:0014896)3.41527736
97negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.38973314
98mesenchyme morphogenesis (GO:0072132)3.38882458
99regulation of skeletal muscle contraction (GO:0014819)3.37885896
100muscle tissue morphogenesis (GO:0060415)3.36652742
101regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.36370375
102skin morphogenesis (GO:0043589)3.31147221
103neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.29859557
104negative regulation of cytosolic calcium ion concentration (GO:0051481)3.28763391
105trabecula formation (GO:0060343)3.26874562
106endodermal cell differentiation (GO:0035987)3.26632321
107calcium-mediated signaling using intracellular calcium source (GO:0035584)3.25886822
108regulation of cardiac muscle cell differentiation (GO:2000725)3.25843383
109negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.22081187
110negative regulation of calcium ion transmembrane transport (GO:1903170)3.22081187
111positive regulation of heart rate (GO:0010460)3.21816636
112fatty acid transmembrane transport (GO:1902001)3.21414362
113relaxation of muscle (GO:0090075)3.21150154
114adhesion of symbiont to host cell (GO:0044650)3.20297600
115virion attachment to host cell (GO:0019062)3.20297600
116heart contraction (GO:0060047)3.20261745
117heart process (GO:0003015)3.20261745
118* regulation of heart contraction (GO:0008016)3.19940172
119regulation of cardiac muscle tissue development (GO:0055024)3.17604499
120regulation of sulfur metabolic process (GO:0042762)3.17367445
121positive regulation of heart growth (GO:0060421)3.16065436
122actin-mediated cell contraction (GO:0070252)3.14641310
123succinate metabolic process (GO:0006105)3.13251529
124adrenergic receptor signaling pathway (GO:0071875)3.13158621
125relaxation of smooth muscle (GO:0044557)3.12643300
126regulation of cation channel activity (GO:2001257)3.10774092
127regulation of glucocorticoid metabolic process (GO:0031943)3.08951711
128regulation of potassium ion transmembrane transporter activity (GO:1901016)3.08276817
129positive regulation of potassium ion transport (GO:0043268)3.07140880
130chondrocyte proliferation (GO:0035988)3.07034527
131cardiac muscle tissue development (GO:0048738)3.06107312
132phenol-containing compound catabolic process (GO:0019336)3.06002810
133regulation of cardioblast proliferation (GO:0003264)3.04646102
134regulation of secondary heart field cardioblast proliferation (GO:0003266)3.04646102
135positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.04493814
136regulation of potassium ion transmembrane transport (GO:1901379)3.03402598
137ventricular cardiac muscle cell development (GO:0055015)3.03050889
138respiratory tube development (GO:0030323)3.01562647
139cellular response to epinephrine stimulus (GO:0071872)3.00919106
140oxidative phosphorylation (GO:0006119)2.99802989
141positive regulation of heart contraction (GO:0045823)2.98822306
142cardiac septum development (GO:0003279)2.95820124
143regulation of cardiac muscle cell proliferation (GO:0060043)2.95429781
144response to epinephrine (GO:0071871)2.92994076
145cardiac muscle adaptation (GO:0014887)2.91577431
146muscle hypertrophy in response to stress (GO:0003299)2.91577431
147negative regulation of hormone metabolic process (GO:0032351)2.89762035
148cellular response to vitamin (GO:0071295)2.89273767
149metanephric mesenchyme development (GO:0072075)2.87849569
150regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.87533748
151lung vasculature development (GO:0060426)2.82135226
152actin filament-based movement (GO:0030048)2.81231002
153regulation of cardiac muscle cell apoptotic process (GO:0010665)2.79858346
154mesodermal cell differentiation (GO:0048333)2.79511823
155response to redox state (GO:0051775)2.76247641
156regulation of muscle contraction (GO:0006937)2.75762729
157positive regulation of cardiac muscle hypertrophy (GO:0010613)2.73929653
158positive regulation of muscle hypertrophy (GO:0014742)2.73929653
159embryonic foregut morphogenesis (GO:0048617)2.70612675
160regulation of smooth muscle cell differentiation (GO:0051150)2.68706043
161positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.66728519

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.10170406
2PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.24517698
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.97173424
4ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.38673884
5* EP300_21415370_ChIP-Seq_HL-1_Mouse3.22713575
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.81501276
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.73854028
8GBX2_23144817_ChIP-Seq_PC3_Human2.66276003
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.58868853
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.38147254
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27633839
12BRD4_25478319_ChIP-Seq_HGPS_Human2.23781178
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.22208420
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.22208420
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.21804463
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.12420923
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.10634549
18TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.08803066
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.02933982
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01309022
21DROSHA_22980978_ChIP-Seq_HELA_Human1.98980269
22* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.97757765
23* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.97393127
24TBX20_22328084_ChIP-Seq_HEART_Mouse1.97269534
25TBX20_22080862_ChIP-Seq_HEART_Mouse1.97269534
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.97199158
27RBPJ_22232070_ChIP-Seq_NCS_Mouse1.97175013
28TAF15_26573619_Chip-Seq_HEK293_Human1.97007523
29CJUN_26792858_Chip-Seq_BT549_Human1.95222472
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.92261808
31TP53_18474530_ChIP-ChIP_U2OS_Human1.90773376
32TP53_16413492_ChIP-PET_HCT116_Human1.89076192
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.87143460
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.82939128
35ESR1_20079471_ChIP-ChIP_T-47D_Human1.76323849
36RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.75919655
37RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.74905872
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.71694498
39ZNF263_19887448_ChIP-Seq_K562_Human1.70335253
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.67436432
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.64239267
42RARB_27405468_Chip-Seq_BRAIN_Mouse1.64020718
43* REST_21632747_ChIP-Seq_MESCs_Mouse1.62533006
44REST_18959480_ChIP-ChIP_MESCs_Mouse1.58372529
45RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57571252
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.57247586
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.56522097
48* SMAD4_21799915_ChIP-Seq_A2780_Human1.55354422
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51402087
50AR_21572438_ChIP-Seq_LNCaP_Human1.49488023
51ZNF274_21170338_ChIP-Seq_K562_Hela1.45361453
52CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.45233722
53TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44791257
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43347508
55* SOX2_21211035_ChIP-Seq_LN229_Gbm1.41120521
56RNF2_27304074_Chip-Seq_ESCs_Mouse1.40885431
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40639641
58MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.37861302
59BCAT_22108803_ChIP-Seq_LS180_Human1.37297262
60TP53_20018659_ChIP-ChIP_R1E_Mouse1.35568439
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34584996
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30957143
63CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.30006256
64NFIB_24661679_ChIP-Seq_LUNG_Mouse1.29480907
65ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28049052
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.27820684
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24764314
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23398263
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.21704887
70CLOCK_20551151_ChIP-Seq_293T_Human1.19729211
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19170142
72BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18106345
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17687798
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.16844621
75SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16096808
76CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.11307779
77SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11089595
78WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10221829
79* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10117386
80FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10099247
81PPAR_26484153_Chip-Seq_NCI-H1993_Human1.09618037
82SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08864679
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07921458
84TP53_23651856_ChIP-Seq_MEFs_Mouse1.07744388
85SMAD4_21741376_ChIP-Seq_HESCs_Human1.07723702
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07578898
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07316147
88SA1_22415368_ChIP-Seq_MEFs_Mouse1.06687144
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05648626
90PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05210081
91NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.04241561
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04168838
93P300_19829295_ChIP-Seq_ESCs_Human1.03897523
94ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03248631
95OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01537951
96SMAD3_21741376_ChIP-Seq_HESCs_Human1.01216727
97SMC3_22415368_ChIP-Seq_MEFs_Mouse1.00920397
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00848397
99AR_25329375_ChIP-Seq_VCAP_Human1.00367169
100RING1B_27294783_Chip-Seq_ESCs_Mouse1.00101638
101AHR_22903824_ChIP-Seq_MCF-7_Human0.99085262
102GATA2_21666600_ChIP-Seq_HMVEC_Human0.98767948
103AR_19668381_ChIP-Seq_PC3_Human0.98472016
104DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98346053
105* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98290981
106TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97284524
107CTCF_27219007_Chip-Seq_Bcells_Human0.97279845
108VDR_22108803_ChIP-Seq_LS180_Human0.96539504
109MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96307927
110NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95920994
111SMC1_22415368_ChIP-Seq_MEFs_Mouse0.95367988
112RARG_19884340_ChIP-ChIP_MEFs_Mouse0.95357865
113JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95267890
114ESR2_21235772_ChIP-Seq_MCF-7_Human0.95145097
115* PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.94406501
116TP53_22127205_ChIP-Seq_IMR90_Human0.94093580
117JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94074285
118GATA4_21415370_ChIP-Seq_HL-1_Mouse0.93383901
119TCF4_23295773_ChIP-Seq_U87_Human0.92915210
120* STAT3_23295773_ChIP-Seq_U87_Human0.92628342
121ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92222894
122* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.91887431
123NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.90337216
124ERG_21242973_ChIP-ChIP_JURKAT_Human0.90189048
125TBX3_20139965_ChIP-Seq_MESCs_Mouse0.90023369
126CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89933664
127SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89568453
128TBX3_20139965_ChIP-Seq_ESCs_Mouse0.89484547
129NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.88248744
130EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87513701
131ARNT_22903824_ChIP-Seq_MCF-7_Human0.87496423
132AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87487910
133MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86809159
134NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86651001
135NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86651001
136WT1_19549856_ChIP-ChIP_CCG9911_Human0.86171108
137RING1B_27294783_Chip-Seq_NPCs_Mouse0.86023969
138* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.85644616
139DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.85623001
140TCF4_18268006_ChIP-ChIP_LS174T_Human0.85617117
141PRDM14_20953172_ChIP-Seq_ESCs_Human0.83880501
142ISL1_27105846_Chip-Seq_CPCs_Mouse0.81429042
143YAP1_20516196_ChIP-Seq_MESCs_Mouse0.81420005

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.96025963
2MP0008438_abnormal_cutaneous_collagen5.66616422
3MP0004084_abnormal_cardiac_muscle4.95603465
4MP0003646_muscle_fatigue4.87758555
5MP0000751_myopathy4.52725218
6MP0004215_abnormal_myocardial_fiber4.46626152
7MP0005503_abnormal_tendon_morphology3.98448638
8MP0004036_abnormal_muscle_relaxation3.66441096
9MP0002822_catalepsy3.37152082
10MP0005330_cardiomyopathy3.17087665
11MP0004272_abnormal_basement_membrane3.16215665
12MP0001958_emphysema3.07517036
13MP0003705_abnormal_hypodermis_morpholog3.05944872
14MP0005275_abnormal_skin_tensile3.01939332
15MP0000749_muscle_degeneration2.81725499
16MP0008775_abnormal_heart_ventricle2.75465036
17MP0002972_abnormal_cardiac_muscle2.73232429
18MP0009384_cardiac_valve_regurgitation2.67655278
19MP0004484_altered_response_of2.62041550
20MP0003137_abnormal_impulse_conducting2.61673684
21MP0005257_abnormal_intraocular_pressure2.38085746
22MP0004087_abnormal_muscle_fiber2.34381475
23MP0004130_abnormal_muscle_cell2.29809588
24MP0006138_congestive_heart_failure2.24204658
25MP0001544_abnormal_cardiovascular_syste2.23854513
26MP0005385_cardiovascular_system_phenoty2.23854513
27* MP0005620_abnormal_muscle_contractility2.21566980
28* MP0004085_abnormal_heartbeat2.16892101
29MP0003566_abnormal_cell_adhesion2.04597419
30MP0001542_abnormal_bone_strength2.03037165
31MP0000767_abnormal_smooth_muscle2.00349010
32MP0003941_abnormal_skin_development1.98697728
33MP0010630_abnormal_cardiac_muscle1.95259056
34MP0002106_abnormal_muscle_physiology1.93570397
35MP0004859_abnormal_synaptic_plasticity1.88559048
36MP0004145_abnormal_muscle_electrophysio1.86708867
37MP0000750_abnormal_muscle_regeneration1.82849935
38MP0004510_myositis1.80406195
39MP0006054_spinal_hemorrhage1.77079615
40MP0002295_abnormal_pulmonary_circulatio1.69681737
41MP0002127_abnormal_cardiovascular_syste1.69650556
42MP0000747_muscle_weakness1.68725520
43MP0000534_abnormal_ureter_morphology1.68547235
44MP0003828_pulmonary_edema1.66619142
45MP0002269_muscular_atrophy1.66026607
46MP0005369_muscle_phenotype1.60916446
47MP0005508_abnormal_skeleton_morphology1.59185335
48MP0003880_abnormal_central_pattern1.59081690
49* MP0003635_abnormal_synaptic_transmissio1.54403152
50MP0003221_abnormal_cardiomyocyte_apopto1.53289326
51MP0002332_abnormal_exercise_endurance1.53221448
52MP0003091_abnormal_cell_migration1.53029976
53MP0004233_abnormal_muscle_weight1.52734137
54MP0000759_abnormal_skeletal_muscle1.52041990
55MP0004270_analgesia1.49409174
56MP0001299_abnormal_eye_distance/1.48660359
57MP0006036_abnormal_mitochondrial_physio1.45962514
58MP0003942_abnormal_urinary_system1.43524219
59* MP0009745_abnormal_behavioral_response1.41690862
60MP0009250_abnormal_appendicular_skeleto1.39732503
61MP0002909_abnormal_adrenal_gland1.38337175
62MP0006276_abnormal_autonomic_nervous1.37079543
63MP0009046_muscle_twitch1.36162849
64MP0002064_seizures1.35406070
65MP0001440_abnormal_grooming_behavior1.32764083
66MP0002102_abnormal_ear_morphology1.31882911
67MP0004858_abnormal_nervous_system1.30577507
68MP0005595_abnormal_vascular_smooth1.23428711
69* MP0004924_abnormal_behavior1.22424480
70* MP0005386_behavior/neurological_phenoty1.22424480
71MP0002735_abnormal_chemical_nociception1.19094185
72MP0000462_abnormal_digestive_system1.19064533
73MP0002254_reproductive_system_inflammat1.16894774
74MP0002734_abnormal_mechanical_nocicepti1.14901114
75MP0002128_abnormal_blood_circulation1.14693007
76* MP0002272_abnormal_nervous_system1.14481922
77MP0003385_abnormal_body_wall1.14261728
78MP0006035_abnormal_mitochondrial_morpho1.12154799
79MP0000733_abnormal_muscle_development1.12113006
80MP0002063_abnormal_learning/memory/cond1.10860351
81MP0009780_abnormal_chondrocyte_physiolo1.09680761
82MP0002572_abnormal_emotion/affect_behav1.05648291
83MP0010386_abnormal_urinary_bladder1.04947257
84MP0005165_increased_susceptibility_to1.01773951
85MP0002896_abnormal_bone_mineralization1.01264704
86MP0008004_abnormal_stomach_pH1.00637677
87MP0005023_abnormal_wound_healing0.98854007
88MP0005623_abnormal_meninges_morphology0.98419874
89MP0000428_abnormal_craniofacial_morphol0.98021644
90MP0008569_lethality_at_weaning0.97969507
91* MP0001970_abnormal_pain_threshold0.97331100
92MP0004043_abnormal_pH_regulation0.97241417
93MP0002638_abnormal_pupillary_reflex0.95437779
94MP0002733_abnormal_thermal_nociception0.94964376
95MP0001501_abnormal_sleep_pattern0.93289934
96MP0001905_abnormal_dopamine_level0.92686074
97MP0000013_abnormal_adipose_tissue0.91860150
98MP0001968_abnormal_touch/_nociception0.90686673
99MP0000230_abnormal_systemic_arterial0.90681371
100MP0003950_abnormal_plasma_membrane0.90385161
101MP0001879_abnormal_lymphatic_vessel0.89794210
102MP0001348_abnormal_lacrimal_gland0.89243077
103MP0003567_abnormal_fetal_cardiomyocyte0.89120350
104MP0002067_abnormal_sensory_capabilities0.88842977
105MP0003279_aneurysm0.87122334
106MP0003633_abnormal_nervous_system0.85845310
107MP0009053_abnormal_anal_canal0.85630502
108MP0005535_abnormal_body_temperature0.85510226
109MP0003283_abnormal_digestive_organ0.83433045
110MP0001986_abnormal_taste_sensitivity0.81699336
111MP0000266_abnormal_heart_morphology0.81134468
112MP0000762_abnormal_tongue_morphology0.79417133
113MP0001486_abnormal_startle_reflex0.76861037
114MP0001243_abnormal_dermal_layer0.75255475
115MP0005390_skeleton_phenotype0.75162911
116MP0010368_abnormal_lymphatic_system0.74839234
117MP0001614_abnormal_blood_vessel0.74093805
118MP0003329_amyloid_beta_deposits0.73618703
119MP0000343_altered_response_to0.73277207
120MP0005167_abnormal_blood-brain_barrier0.72351331
121MP0005666_abnormal_adipose_tissue0.72220674
122MP0002108_abnormal_muscle_morphology0.71858824
123MP0004142_abnormal_muscle_tone0.71583164
124MP0003935_abnormal_craniofacial_develop0.71213987
125MP0002925_abnormal_cardiovascular_devel0.68071930
126MP0002060_abnormal_skin_morphology0.67792099
127MP0010352_gastrointestinal_tract_polyps0.67385228
128MP0002115_abnormal_skeleton_extremities0.66617128
129MP0002234_abnormal_pharynx_morphology0.66318486
130MP0010030_abnormal_orbit_morphology0.65997025
131MP0003937_abnormal_limbs/digits/tail_de0.65782422
132MP0001661_extended_life_span0.65755853
133MP0002184_abnormal_innervation0.65067175
134MP0005266_abnormal_metabolism0.63808419
135MP0005423_abnormal_somatic_nervous0.62715238
136MP0004147_increased_porphyrin_level0.62583366
137MP0002736_abnormal_nociception_after0.62373857
138MP0000049_abnormal_middle_ear0.61987305
139MP0002066_abnormal_motor_capabilities/c0.61340313
140MP0000432_abnormal_head_morphology0.60632156
141MP0000163_abnormal_cartilage_morphology0.60073209
142MP0003045_fibrosis0.59665487
143MP0003631_nervous_system_phenotype0.58468106
144MP0005187_abnormal_penis_morphology0.58028053
145MP0003122_maternal_imprinting0.57188083
146MP0004134_abnormal_chest_morphology0.57101684
147MP0004811_abnormal_neuron_physiology0.56999918
148MP0005171_absent_coat_pigmentation0.56657966
149MP0001664_abnormal_digestion0.56289130
150MP0005164_abnormal_response_to0.55448390
151MP0002090_abnormal_vision0.54389170
152MP0008872_abnormal_physiological_respon0.53986253
153MP0003755_abnormal_palate_morphology0.52943896
154MP0005375_adipose_tissue_phenotype0.52287278
155MP0002078_abnormal_glucose_homeostasis0.51477451
156MP0000955_abnormal_spinal_cord0.51436245

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.51080241
2Premature rupture of membranes (HP:0001788)6.11463376
3Atrial fibrillation (HP:0005110)5.89079968
4Ventricular tachycardia (HP:0004756)5.88606251
5Protrusio acetabuli (HP:0003179)5.64635154
6Primary atrial arrhythmia (HP:0001692)5.59544761
7Aortic aneurysm (HP:0004942)5.56591395
8Supraventricular tachycardia (HP:0004755)5.38557104
9Syncope (HP:0001279)5.27666303
10Supraventricular arrhythmia (HP:0005115)5.26246218
11Type 1 muscle fiber predominance (HP:0003803)5.15167312
12Calf muscle hypertrophy (HP:0008981)5.15072708
13Vascular tortuosity (HP:0004948)4.99289944
14Aortic dissection (HP:0002647)4.95631833
15Muscle hypertrophy of the lower extremities (HP:0008968)4.74471634
16Bundle branch block (HP:0011710)4.51860340
17Exercise-induced myalgia (HP:0003738)4.51492213
18Prolonged QT interval (HP:0001657)4.42421967
19Exercise-induced muscle cramps (HP:0003710)4.42214834
20Abnormality of the calf musculature (HP:0001430)4.38481481
21Lipoatrophy (HP:0100578)4.38354455
22Right ventricular cardiomyopathy (HP:0011663)4.35394107
23Palpitations (HP:0001962)4.34198559
24Arterial tortuosity (HP:0005116)4.30886390
25Muscle fiber splitting (HP:0003555)4.23940170
26Ankle contracture (HP:0006466)4.21159442
27Ventricular fibrillation (HP:0001663)4.06619354
28Hyporeflexia of lower limbs (HP:0002600)4.03425192
29Myoglobinuria (HP:0002913)4.00872554
30Follicular hyperkeratosis (HP:0007502)3.92740694
31Ventricular arrhythmia (HP:0004308)3.80419246
32Soft skin (HP:0000977)3.80073322
33Heart block (HP:0012722)3.60329703
34Abnormal mitochondria in muscle tissue (HP:0008316)3.59119497
35Acute necrotizing encephalopathy (HP:0006965)3.58190134
36Myotonia (HP:0002486)3.57537466
37Dilated cardiomyopathy (HP:0001644)3.57039008
38Bladder diverticulum (HP:0000015)3.51437731
39Abnormality of dentin (HP:0010299)3.47952666
40Pheochromocytoma (HP:0002666)3.42584925
41Atrioventricular block (HP:0001678)3.40751376
42Abnormal EKG (HP:0003115)3.37928889
43Abnormal atrioventricular conduction (HP:0005150)3.36529382
44Spinal rigidity (HP:0003306)3.29350274
45Subaortic stenosis (HP:0001682)3.27974781
46Abnormality of the left ventricular outflow tract (HP:0011103)3.27974781
47Wormian bones (HP:0002645)3.24777636
48Hypoplastic left heart (HP:0004383)3.23593105
49Mildly elevated creatine phosphokinase (HP:0008180)3.23557875
50Neonatal short-limb short stature (HP:0008921)3.21219406
51EMG: myopathic abnormalities (HP:0003458)3.20743977
52Progressive macrocephaly (HP:0004481)3.16083399
53Neuroendocrine neoplasm (HP:0100634)3.11245212
54Hypoventilation (HP:0002791)3.09988183
55Asymmetric septal hypertrophy (HP:0001670)3.03574819
56Hepatic necrosis (HP:0002605)3.01212673
57Dilatation of the ascending aorta (HP:0005111)3.00117600
58Slender build (HP:0001533)2.99721646
59Left ventricular hypertrophy (HP:0001712)2.98681005
60Aneurysm (HP:0002617)2.98042007
61Myokymia (HP:0002411)2.97802162
62Acute encephalopathy (HP:0006846)2.95819657
63Peritonitis (HP:0002586)2.94050106
64Mitochondrial inheritance (HP:0001427)2.92166477
65Atrophic scars (HP:0001075)2.91501677
66Spondylolisthesis (HP:0003302)2.90985370
67Hepatocellular necrosis (HP:0001404)2.87378741
68Rhabdomyolysis (HP:0003201)2.75202718
69Increased connective tissue (HP:0009025)2.75169995
70Mitral valve prolapse (HP:0001634)2.74698396
71Focal motor seizures (HP:0011153)2.74511392
72Long toe (HP:0010511)2.73503981
73Fragile skin (HP:0001030)2.70993192
74Difficulty running (HP:0009046)2.70230048
75Wide anterior fontanel (HP:0000260)2.69796549
76Cervical subluxation (HP:0003308)2.69612582
77Increased CSF lactate (HP:0002490)2.67209585
78Elbow flexion contracture (HP:0002987)2.63941633
79Bowel diverticulosis (HP:0005222)2.58819621
80Ketoacidosis (HP:0001993)2.58629255
81Hypothermia (HP:0002045)2.57375100
82Abnormality of the pulmonary veins (HP:0011718)2.57050902
83Cerebral edema (HP:0002181)2.56316700
84Abnormal umbilical cord blood vessels (HP:0011403)2.49997333
85Single umbilical artery (HP:0001195)2.49997333
86Abnormality of the fetal cardiovascular system (HP:0010948)2.49997333
87Coronal craniosynostosis (HP:0004440)2.45037204
88Hip contracture (HP:0003273)2.44104163
89Hypoplastic heart (HP:0001961)2.43946960
90Conjunctival hamartoma (HP:0100780)2.39884358
91Dysmetric saccades (HP:0000641)2.38268734
92Complete atrioventricular canal defect (HP:0001674)2.33767156
93Muscle stiffness (HP:0003552)2.30362944
94Blue sclerae (HP:0000592)2.30306605
95Mitral regurgitation (HP:0001653)2.29870194
96Hydroureter (HP:0000072)2.28476176
97Joint laxity (HP:0001388)2.28207626
98Increased muscle lipid content (HP:0009058)2.27537385
99Respiratory failure (HP:0002878)2.26381533
100Shallow orbits (HP:0000586)2.26213618
101Lactic acidosis (HP:0003128)2.26034637
102Overgrowth (HP:0001548)2.24610697
103Central scotoma (HP:0000603)2.24566355
104Aortic regurgitation (HP:0001659)2.23628540
105Partial duplication of the phalanx of hand (HP:0009999)2.22876373
106Difficulty climbing stairs (HP:0003551)2.18484333
107Knee flexion contracture (HP:0006380)2.18068793
108Foot dorsiflexor weakness (HP:0009027)2.17284310
109Hyperextensible skin (HP:0000974)2.16730628
110Palmoplantar keratoderma (HP:0000982)2.15751203
111Increased variability in muscle fiber diameter (HP:0003557)2.15371233
112Increased serum pyruvate (HP:0003542)2.14609635
113Abnormality of glycolysis (HP:0004366)2.14609635
114Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.14340612
115Abnormality of alanine metabolism (HP:0010916)2.14340612
116Hyperalaninemia (HP:0003348)2.14340612
117Increased intramyocellular lipid droplets (HP:0012240)2.14141968
118Limited hip movement (HP:0008800)2.12373472
119Genu recurvatum (HP:0002816)2.11361405
120Abnormality of the foot musculature (HP:0001436)2.11272893
121Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.11092070
122Sudden cardiac death (HP:0001645)2.11005099
123Hamartoma of the eye (HP:0010568)2.09653605
124Visual hallucinations (HP:0002367)2.07297261
125Camptodactyly of toe (HP:0001836)2.06327737
126Exercise intolerance (HP:0003546)2.04615637
127Bradycardia (HP:0001662)2.04592786
128Abnormality of the vocal cords (HP:0008777)2.03644001
129Disproportionate tall stature (HP:0001519)2.03459251
130Hypoglycemic coma (HP:0001325)2.01299479
131Limb-girdle muscle atrophy (HP:0003797)2.01128295
132Focal seizures (HP:0007359)2.00861642
133Partial duplication of thumb phalanx (HP:0009944)1.99658492
134Ragged-red muscle fibers (HP:0003200)1.99141925
135Pulmonary artery stenosis (HP:0004415)1.99075745
136Neoplasm of the adrenal gland (HP:0100631)1.96789186
137Biconcave vertebral bodies (HP:0004586)1.95974385
138Atrioventricular canal defect (HP:0006695)1.95279398
139Distal lower limb muscle weakness (HP:0009053)1.93579055
140Neoplasm of the peripheral nervous system (HP:0100007)1.92839108
141Cerebral hemorrhage (HP:0001342)1.92556954
142Athetosis (HP:0002305)1.89845706
143Abnormality of fatty-acid metabolism (HP:0004359)1.88729110
144Rapidly progressive (HP:0003678)1.88270006
145Areflexia of lower limbs (HP:0002522)1.88260413
146Dicarboxylic aciduria (HP:0003215)1.87178552
147Abnormality of dicarboxylic acid metabolism (HP:0010995)1.87178552
148Patent foramen ovale (HP:0001655)1.86525158
149Limb-girdle muscle weakness (HP:0003325)1.86261246
150Ectopia lentis (HP:0001083)1.85139101
151Abnormality of the umbilical cord (HP:0010881)1.83741613
152Optic disc pallor (HP:0000543)1.82937141
153Generalized amyotrophy (HP:0003700)1.82415458
154Cerebral aneurysm (HP:0004944)1.81417812
155Lipid accumulation in hepatocytes (HP:0006561)1.81087913
156Muscle fiber inclusion bodies (HP:0100299)1.80381749
157Mesomelia (HP:0003027)1.80027253
158Lower limb amyotrophy (HP:0007210)1.79997752
159Distal upper limb amyotrophy (HP:0007149)1.79860337
160Upper limb amyotrophy (HP:0009129)1.79860337
161Distal lower limb amyotrophy (HP:0008944)1.79619510
162Anxiety (HP:0000739)1.77585207
163Broad metatarsal (HP:0001783)1.76696918
164Tinnitus (HP:0000360)1.75963052
165Congestive heart failure (HP:0001635)1.74820045
166Atonic seizures (HP:0010819)1.73120579
167Abnormality of skeletal muscle fiber size (HP:0012084)1.73094342
168Impaired pain sensation (HP:0007328)1.73075340

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK24.32440268
2TTN3.89862944
3PHKG23.76949644
4PHKG13.76949644
5MYLK3.44755560
6PDK43.44672497
7PDK33.44672497
8DDR22.83331374
9PIK3CG2.74016096
10FLT32.58952647
11MAP3K42.44181955
12NEK92.34484892
13OBSCN2.33868781
14PAK22.19953916
15DMPK2.19925789
16NEK12.05572424
17PDK22.05081069
18PKN21.99309373
19NTRK31.98636629
20AKT31.92754857
21PINK11.82352268
22TIE11.76484583
23NTRK11.74439839
24PTK21.69056175
25STK241.67345747
26MUSK1.64445890
27PAK31.63479188
28MAP2K41.59602430
29CAMK2D1.58002575
30MAP2K71.57556728
31PIK3CA1.56658560
32MAP3K121.56387306
33EPHB21.56107167
34LATS11.51305306
35TESK11.48819740
36TGFBR21.38119256
37WNK11.36173318
38MINK11.32795567
39WNK41.28298276
40MARK11.28179033
41ADRBK21.27931721
42PRKD21.23360371
43MAP3K91.21521699
44GRK51.20325799
45SIK11.18987344
46BCKDK1.17173711
47CAMK2A1.15982125
48TRIB31.13300329
49PRKD11.04769389
50CAMK41.04326532
51STK38L1.01893613
52STK391.01565676
53CASK0.99347733
54PAK60.95260957
55INSRR0.94722953
56PRKCE0.94358699
57CAMK10.92914608
58STK380.91640677
59DYRK1B0.91023085
60UHMK10.90318251
61ROCK10.89859019
62EPHA40.89763094
63KSR20.89440655
64LATS20.89137777
65CDC42BPA0.89044754
66ERBB40.88752215
67DAPK20.82817555
68PDGFRB0.82166773
69ILK0.80941698
70DAPK30.78437189
71GRK10.77339504
72RET0.75543005
73CAMK2G0.75343418
74ROCK20.75317666
75* ADRBK10.73563732
76MAP3K60.73488012
77MAP3K70.72631439
78KIT0.71494934
79PRKG20.68055966
80MAPK120.67170961
81PRKAA10.66155989
82PRKCH0.65266154
83NTRK20.65087552
84SGK2230.62049092
85SGK4940.62049092
86CDK50.61446443
87MET0.61127401
88CAMKK10.60148729
89MAP2K10.58621560
90MAP3K50.58287467
91PDGFRA0.58042947
92PTK2B0.58015754
93PKN10.56914727
94PRKACA0.56660649
95PDPK10.56431555
96PRKACB0.55855261
97LIMK10.53451035
98CAMK2B0.53107580
99SGK20.52818461
100FER0.52579819
101PRKACG0.52569726
102MAPK130.52564165
103SGK30.52544393
104PLK20.51811612
105RPS6KL10.51257774
106RPS6KC10.51257774
107PRKD30.50928098
108MAPK40.50019075
109JAK10.49832577
110PDK10.49720079
111PIM20.47970278
112ABL20.47448777
113GSK3A0.46283205
114RIPK10.46045269
115MELK0.45337121
116PRKAA20.44037506
117RPS6KA20.43259189
118PRKCG0.42684089
119MTOR0.42164914
120MAP3K10.40921024
121STK110.39975615
122MAPK70.39611566
123PAK40.39367378
124SGK10.39290591
125CAMKK20.39272832
126TRPM70.38847530
127MAPKAPK30.38676852
128EPHB10.38375272
129RPS6KA60.37432920
130PNCK0.37366137
131ICK0.35769276
132FGFR10.34599511
133RPS6KA30.31705342
134STK40.31372678
135PRKG10.29574142
136CDK80.28126267
137ARAF0.27598465
138PAK10.26676042
139ERN10.25080902
140DAPK10.24510762
141STK30.22329775
142SRC0.21497675
143MOS0.21339763
144TGFBR10.20245006
145MAPKAPK20.20188872
146PRKCD0.19507497
147GRK60.19253449

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.74082986
2Cardiac muscle contraction_Homo sapiens_hsa042603.49795357
3ECM-receptor interaction_Homo sapiens_hsa045123.34401623
4Oxidative phosphorylation_Homo sapiens_hsa001903.26572931
5Parkinsons disease_Homo sapiens_hsa050123.14062611
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.00702440
7Dilated cardiomyopathy_Homo sapiens_hsa054142.77740917
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.61119545
9Alzheimers disease_Homo sapiens_hsa050102.45263666
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.43746748
11Propanoate metabolism_Homo sapiens_hsa006402.30126426
12Protein digestion and absorption_Homo sapiens_hsa049741.99104482
13Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.97539044
14Huntingtons disease_Homo sapiens_hsa050161.94547815
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.92152940
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.83664778
17Fatty acid degradation_Homo sapiens_hsa000711.83466277
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.82327565
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.81134132
20* Regulation of actin cytoskeleton_Homo sapiens_hsa048101.69358130
21Proteoglycans in cancer_Homo sapiens_hsa052051.68680717
22Carbon metabolism_Homo sapiens_hsa012001.62749859
23Amoebiasis_Homo sapiens_hsa051461.59955300
24Fatty acid metabolism_Homo sapiens_hsa012121.56223252
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52796085
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51463706
27TGF-beta signaling pathway_Homo sapiens_hsa043501.48233936
28Synaptic vesicle cycle_Homo sapiens_hsa047211.46613312
29Pyruvate metabolism_Homo sapiens_hsa006201.45133845
30Adherens junction_Homo sapiens_hsa045201.44819567
31Circadian entrainment_Homo sapiens_hsa047131.43708161
32Olfactory transduction_Homo sapiens_hsa047401.40961591
33Butanoate metabolism_Homo sapiens_hsa006501.40757313
34Melanoma_Homo sapiens_hsa052181.38711436
35Hippo signaling pathway_Homo sapiens_hsa043901.36342000
36Hedgehog signaling pathway_Homo sapiens_hsa043401.36337732
37Renin secretion_Homo sapiens_hsa049241.33704183
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.30428344
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28619658
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.28026595
41Gastric acid secretion_Homo sapiens_hsa049711.27407577
42Basal cell carcinoma_Homo sapiens_hsa052171.27399845
43Insulin secretion_Homo sapiens_hsa049111.25689972
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.22839451
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22050365
46* Calcium signaling pathway_Homo sapiens_hsa040201.19371807
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.17435321
48Amphetamine addiction_Homo sapiens_hsa050311.13378387
49Dopaminergic synapse_Homo sapiens_hsa047281.13258591
50Oxytocin signaling pathway_Homo sapiens_hsa049211.12773485
51* Cholinergic synapse_Homo sapiens_hsa047251.11951335
52cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11131553
53GABAergic synapse_Homo sapiens_hsa047271.09992121
54* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.09033335
55Taste transduction_Homo sapiens_hsa047421.08807126
56Long-term potentiation_Homo sapiens_hsa047201.08565569
57Fatty acid elongation_Homo sapiens_hsa000621.07334797
58Morphine addiction_Homo sapiens_hsa050321.06497262
59Nicotine addiction_Homo sapiens_hsa050331.05746245
60Salivary secretion_Homo sapiens_hsa049701.04207971
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.99851955
62Collecting duct acid secretion_Homo sapiens_hsa049660.98966228
63Small cell lung cancer_Homo sapiens_hsa052220.97885251
64Aldosterone synthesis and secretion_Homo sapiens_hsa049250.96234362
65Phenylalanine metabolism_Homo sapiens_hsa003600.96113190
66Glutamatergic synapse_Homo sapiens_hsa047240.95375137
67Pathways in cancer_Homo sapiens_hsa052000.94030998
68Glucagon signaling pathway_Homo sapiens_hsa049220.92990089
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.91256219
70Type II diabetes mellitus_Homo sapiens_hsa049300.91177828
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87796873
72Gap junction_Homo sapiens_hsa045400.87380173
73Serotonergic synapse_Homo sapiens_hsa047260.86484536
74Cocaine addiction_Homo sapiens_hsa050300.84583143
75Platelet activation_Homo sapiens_hsa046110.82702661
76GnRH signaling pathway_Homo sapiens_hsa049120.81153651
77* cAMP signaling pathway_Homo sapiens_hsa040240.80013751
78Viral myocarditis_Homo sapiens_hsa054160.78344658
79Complement and coagulation cascades_Homo sapiens_hsa046100.77429568
80Rap1 signaling pathway_Homo sapiens_hsa040150.77280180
81Insulin signaling pathway_Homo sapiens_hsa049100.76507953
82Arginine biosynthesis_Homo sapiens_hsa002200.75074586
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74817951
84MicroRNAs in cancer_Homo sapiens_hsa052060.74545612
85Tyrosine metabolism_Homo sapiens_hsa003500.74499111
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71232247
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.70334784
88Wnt signaling pathway_Homo sapiens_hsa043100.70141771
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69213617
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68966494
91Bladder cancer_Homo sapiens_hsa052190.68837446
92Thyroid hormone synthesis_Homo sapiens_hsa049180.63947945
93Tryptophan metabolism_Homo sapiens_hsa003800.63083631
94Dorso-ventral axis formation_Homo sapiens_hsa043200.62349253
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62271312
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61633843
97Insulin resistance_Homo sapiens_hsa049310.60927827
98Estrogen signaling pathway_Homo sapiens_hsa049150.59808840
99Prion diseases_Homo sapiens_hsa050200.59803232
100Pancreatic secretion_Homo sapiens_hsa049720.58395123
101Glioma_Homo sapiens_hsa052140.58250572
102Vibrio cholerae infection_Homo sapiens_hsa051100.54852036
103Long-term depression_Homo sapiens_hsa047300.54465955
104Endometrial cancer_Homo sapiens_hsa052130.54385749
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54274603
106Prostate cancer_Homo sapiens_hsa052150.51850363
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51708316
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51638396
109PPAR signaling pathway_Homo sapiens_hsa033200.49481139
110Biosynthesis of amino acids_Homo sapiens_hsa012300.48611774
111Sulfur metabolism_Homo sapiens_hsa009200.47702691
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47321887
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45455810
114Chronic myeloid leukemia_Homo sapiens_hsa052200.44963780
115Ras signaling pathway_Homo sapiens_hsa040140.43931648
116Arginine and proline metabolism_Homo sapiens_hsa003300.43750294
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42897071
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41479549
119AMPK signaling pathway_Homo sapiens_hsa041520.40952760
120Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40624033
121Circadian rhythm_Homo sapiens_hsa047100.40260487
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39496318
123mTOR signaling pathway_Homo sapiens_hsa041500.38866387
124HIF-1 signaling pathway_Homo sapiens_hsa040660.38750231
125Endocytosis_Homo sapiens_hsa041440.38174120
126Starch and sucrose metabolism_Homo sapiens_hsa005000.38149072
127Malaria_Homo sapiens_hsa051440.38114061
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.37702898
129Bile secretion_Homo sapiens_hsa049760.37570724
130Focal adhesion_Homo sapiens_hsa045100.36809692
131Melanogenesis_Homo sapiens_hsa049160.36542560
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.36468278
133Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33545242
134beta-Alanine metabolism_Homo sapiens_hsa004100.31608287
135Axon guidance_Homo sapiens_hsa043600.31445232
136Ovarian steroidogenesis_Homo sapiens_hsa049130.31322463
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.29718675
138Fatty acid biosynthesis_Homo sapiens_hsa000610.29294464
139* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.27334345
140Tight junction_Homo sapiens_hsa045300.26817206
141Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.25859853
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25308952
143Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.23644343
144MAPK signaling pathway_Homo sapiens_hsa040100.21813325
145Renal cell carcinoma_Homo sapiens_hsa052110.21587900

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