CHRM5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, stimulation of this receptor is known to increase cyclic AMP levels. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* dopamine transport (GO:0015872)6.19159378
2neuron cell-cell adhesion (GO:0007158)5.83444233
3dopamine biosynthetic process (GO:0042416)5.80941793
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.94463734
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.76108104
6neuron recognition (GO:0008038)4.70686602
7* catecholamine transport (GO:0051937)4.69593270
8synaptic vesicle exocytosis (GO:0016079)4.63040932
9vocalization behavior (GO:0071625)4.62487715
10ionotropic glutamate receptor signaling pathway (GO:0035235)4.59902349
11behavioral response to nicotine (GO:0035095)4.59229633
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.40618953
13mating behavior (GO:0007617)4.35635209
14neural tube formation (GO:0001841)4.34669362
15protein localization to synapse (GO:0035418)4.34173873
16gamma-aminobutyric acid signaling pathway (GO:0007214)4.27450010
17regulation of catecholamine metabolic process (GO:0042069)4.24892225
18regulation of dopamine metabolic process (GO:0042053)4.24892225
19fucose catabolic process (GO:0019317)4.22142719
20L-fucose metabolic process (GO:0042354)4.22142719
21L-fucose catabolic process (GO:0042355)4.22142719
22glutamate receptor signaling pathway (GO:0007215)4.20431237
23indolalkylamine metabolic process (GO:0006586)4.17700915
24exploration behavior (GO:0035640)4.11562474
25response to histamine (GO:0034776)4.11027112
26glutamate secretion (GO:0014047)4.07883210
27regulation of protein kinase A signaling (GO:0010738)4.07155216
28negative regulation of neurotransmitter transport (GO:0051589)4.03527791
29prepulse inhibition (GO:0060134)3.97396802
30mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.96296971
31behavioral response to cocaine (GO:0048148)3.94648789
32opioid receptor signaling pathway (GO:0038003)3.93100640
33regulation of vesicle fusion (GO:0031338)3.88575126
34piRNA metabolic process (GO:0034587)3.86401443
35response to pheromone (GO:0019236)3.86250948
36protein K11-linked deubiquitination (GO:0035871)3.84356707
37behavioral response to ethanol (GO:0048149)3.83484457
38neuron-neuron synaptic transmission (GO:0007270)3.82986534
39regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.82697305
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.81874788
41tryptophan catabolic process (GO:0006569)3.75069376
42indole-containing compound catabolic process (GO:0042436)3.75069376
43indolalkylamine catabolic process (GO:0046218)3.75069376
44regulation of glutamate receptor signaling pathway (GO:1900449)3.73987673
45detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.73903468
46regulation of long-term neuronal synaptic plasticity (GO:0048169)3.72548610
47regulation of synaptic vesicle exocytosis (GO:2000300)3.71995966
48positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.70649181
49dendritic spine morphogenesis (GO:0060997)3.69032017
50synaptic transmission, dopaminergic (GO:0001963)3.68345566
51presynaptic membrane assembly (GO:0097105)3.66761909
52proline transport (GO:0015824)3.66041590
53neurotransmitter transport (GO:0006836)3.61622228
54positive regulation of synapse assembly (GO:0051965)3.58037059
55ATP synthesis coupled proton transport (GO:0015986)3.57994172
56energy coupled proton transport, down electrochemical gradient (GO:0015985)3.57994172
57locomotory exploration behavior (GO:0035641)3.57845171
58synaptic transmission, glutamatergic (GO:0035249)3.57509058
59neurotransmitter secretion (GO:0007269)3.57394291
60behavioral defense response (GO:0002209)3.56994246
61behavioral fear response (GO:0001662)3.56994246
62photoreceptor cell maintenance (GO:0045494)3.56344608
63axonal fasciculation (GO:0007413)3.55910388
64kynurenine metabolic process (GO:0070189)3.53569444
65righting reflex (GO:0060013)3.52083830
66neuronal action potential propagation (GO:0019227)3.51934544
67regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.51569469
68neurotransmitter catabolic process (GO:0042135)3.47986558
69respiratory electron transport chain (GO:0022904)3.47617980
70regulation of postsynaptic membrane potential (GO:0060078)3.46202174
71fear response (GO:0042596)3.45238375
72regulation of neurotransmitter levels (GO:0001505)3.45078211
73catechol-containing compound biosynthetic process (GO:0009713)3.42792779
74catecholamine biosynthetic process (GO:0042423)3.42792779
75detection of light stimulus involved in visual perception (GO:0050908)3.42548723
76detection of light stimulus involved in sensory perception (GO:0050962)3.42548723
77cellular ketone body metabolic process (GO:0046950)3.41035999
78positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.39965143
79electron transport chain (GO:0022900)3.39621881
80neuromuscular process controlling posture (GO:0050884)3.38450700
81layer formation in cerebral cortex (GO:0021819)3.37481365
82tryptophan metabolic process (GO:0006568)3.35729875
83synaptic vesicle maturation (GO:0016188)3.34843624
84positive regulation of dendritic spine development (GO:0060999)3.32927727
85positive regulation of synaptic transmission, GABAergic (GO:0032230)3.31465068
86multicellular organism reproduction (GO:0032504)3.31334667
87regulation of synaptic vesicle transport (GO:1902803)3.31221141
88positive regulation of response to oxidative stress (GO:1902884)3.29236502
89positive regulation of cellular response to oxidative stress (GO:1900409)3.29236502
90long-term memory (GO:0007616)3.28122149
91regulation of excitatory postsynaptic membrane potential (GO:0060079)3.28117849
92retinal cone cell development (GO:0046549)3.26670245
93startle response (GO:0001964)3.25349444
94epithelial cilium movement (GO:0003351)3.25019598
95presynaptic membrane organization (GO:0097090)3.23208332
96regulation of neuronal synaptic plasticity (GO:0048168)3.22267188
97neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.21845351
98gamma-aminobutyric acid transport (GO:0015812)3.20741418
99response to cocaine (GO:0042220)3.19320066
100synaptic vesicle endocytosis (GO:0048488)3.18391041
101epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.17496251
102negative regulation of synaptic transmission, GABAergic (GO:0032229)3.17496221
103regulation of memory T cell differentiation (GO:0043380)3.16133831
104axoneme assembly (GO:0035082)3.15871329
105cilium or flagellum-dependent cell motility (GO:0001539)3.14089018
106protein localization to cilium (GO:0061512)3.13041334
107regulation of synapse structural plasticity (GO:0051823)3.12372144
108synapse assembly (GO:0007416)3.12079812
109indole-containing compound metabolic process (GO:0042430)3.11774434
110postsynaptic membrane organization (GO:0001941)3.11700658
111alkaloid metabolic process (GO:0009820)3.10673759
112regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.09704131
113protein prenylation (GO:0018342)3.08797997
114prenylation (GO:0097354)3.08797997
115negative regulation of cytosolic calcium ion concentration (GO:0051481)3.08485261
116G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.06870973
117negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.05591659
118nonmotile primary cilium assembly (GO:0035058)3.05451670
119neuron remodeling (GO:0016322)3.04988151
120ketone body metabolic process (GO:1902224)3.04975865
121DNA methylation involved in gamete generation (GO:0043046)3.04110958
122reflex (GO:0060004)3.03071838
123reciprocal DNA recombination (GO:0035825)3.02732272
124reciprocal meiotic recombination (GO:0007131)3.02732272
125regulation of dendritic spine morphogenesis (GO:0061001)3.01195816
126respiratory chain complex IV assembly (GO:0008535)3.00092566
127positive regulation of neurotransmitter secretion (GO:0001956)3.00007111
128neuronal action potential (GO:0019228)2.99735643
129regulation of glutamate secretion (GO:0014048)2.98868358
130positive regulation of neurotransmitter transport (GO:0051590)2.97777998
131replication fork processing (GO:0031297)2.97490260
132innervation (GO:0060384)2.97185136
133neurotransmitter uptake (GO:0001504)2.97034735
134regulation of meiosis I (GO:0060631)2.96710572
135positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.95480051
136suckling behavior (GO:0001967)2.93277451
137negative regulation of mast cell activation (GO:0033004)2.92415039
138platelet dense granule organization (GO:0060155)2.92302461
139regulation of dendritic spine development (GO:0060998)2.92005202
140neurotransmitter biosynthetic process (GO:0042136)2.88518642
141pyrimidine nucleobase catabolic process (GO:0006208)2.88352556
142regulation of synaptic transmission, glutamatergic (GO:0051966)2.88251026
143calcium-mediated signaling using intracellular calcium source (GO:0035584)2.87413155
144* transmission of nerve impulse (GO:0019226)2.87330142
145male meiosis I (GO:0007141)2.86909585
146synapsis (GO:0007129)2.86391334
147long-term synaptic potentiation (GO:0060291)2.84833147
148DNA double-strand break processing (GO:0000729)2.83263949
149protein polyglutamylation (GO:0018095)2.81653931
150regulation of acrosome reaction (GO:0060046)2.81604985
151regulation of hippo signaling (GO:0035330)2.81451868
152cilium morphogenesis (GO:0060271)2.80525775
153cytochrome complex assembly (GO:0017004)2.80190534
154mannosylation (GO:0097502)2.78436405
155cilium movement (GO:0003341)2.77050290
156establishment of protein localization to Golgi (GO:0072600)2.76988403
157sulfation (GO:0051923)2.76423367
158cellular biogenic amine catabolic process (GO:0042402)2.75929676
159amine catabolic process (GO:0009310)2.75929676
160intraciliary transport (GO:0042073)2.74346409
161water-soluble vitamin biosynthetic process (GO:0042364)2.73869595
162double-strand break repair via homologous recombination (GO:0000724)2.73508944
163regulation of cilium movement (GO:0003352)2.73280009
164recombinational repair (GO:0000725)2.73231378
165cilium organization (GO:0044782)2.72248973
166sperm motility (GO:0030317)2.72071855
167adaptation of signaling pathway (GO:0023058)2.70347243
168cilium assembly (GO:0042384)2.65552628
169nucleobase catabolic process (GO:0046113)2.62546005
170regulation of glucokinase activity (GO:0033131)2.61772068
171regulation of hexokinase activity (GO:1903299)2.61772068
172preassembly of GPI anchor in ER membrane (GO:0016254)2.61594634
173regulation of collateral sprouting (GO:0048670)2.57628331
174cornea development in camera-type eye (GO:0061303)2.57318389
175oxidative demethylation (GO:0070989)2.56740065
176L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.56029786
177auditory receptor cell stereocilium organization (GO:0060088)2.54950105
178embryonic epithelial tube formation (GO:0001838)2.53870706
179inner ear receptor stereocilium organization (GO:0060122)2.53358442
180thyroid hormone metabolic process (GO:0042403)2.53071458
181positive regulation of oligodendrocyte differentiation (GO:0048714)2.53061677
182DNA deamination (GO:0045006)2.52633651
183RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.52360868
184tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.52360868
185primary amino compound metabolic process (GO:1901160)2.50681229
186C4-dicarboxylate transport (GO:0015740)2.50527670
187serotonin metabolic process (GO:0042428)2.50206948
188DNA integration (GO:0015074)2.48823696
189spinal cord motor neuron differentiation (GO:0021522)2.44931304
190central nervous system neuron axonogenesis (GO:0021955)2.43157595
191protein complex biogenesis (GO:0070271)2.42498051
192positive regulation of meiosis (GO:0045836)2.42423615
193adenosine metabolic process (GO:0046085)2.41944368
194regulation of action potential (GO:0098900)2.41609935
195synaptic transmission, cholinergic (GO:0007271)2.40831583
196photoreceptor cell development (GO:0042461)2.40809371

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.51147811
2GBX2_23144817_ChIP-Seq_PC3_Human3.73751714
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.23161020
4TAF15_26573619_Chip-Seq_HEK293_Human3.21493879
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.21487802
6JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09515392
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.82076118
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.62825453
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.62825453
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.58757407
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.57595986
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52330133
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.48351877
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46766149
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.46493947
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.43005691
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.38985110
18REST_21632747_ChIP-Seq_MESCs_Mouse2.36933179
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.30768738
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.30105835
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.22151365
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21789425
23SALL1_21062744_ChIP-ChIP_HESCs_Human2.20921925
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.15863709
25CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15164007
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.06974450
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.01371673
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.95183420
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.93280334
30AR_21572438_ChIP-Seq_LNCaP_Human1.93106729
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.92163059
32DROSHA_22980978_ChIP-Seq_HELA_Human1.85638543
33SMAD4_21799915_ChIP-Seq_A2780_Human1.82018023
34* P300_19829295_ChIP-Seq_ESCs_Human1.80791996
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.78645451
36CBP_20019798_ChIP-Seq_JUKART_Human1.78645451
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75214539
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71476502
39* RARB_27405468_Chip-Seq_BRAIN_Mouse1.68641358
40ZNF274_21170338_ChIP-Seq_K562_Hela1.68529683
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.68372327
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64691938
43IGF1R_20145208_ChIP-Seq_DFB_Human1.63999313
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61831857
45FUS_26573619_Chip-Seq_HEK293_Human1.59112094
46VDR_22108803_ChIP-Seq_LS180_Human1.58105217
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57892673
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57766502
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56427772
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53540180
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.51366421
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50794560
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.49920057
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49644160
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48856388
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48620494
57TP53_22573176_ChIP-Seq_HFKS_Human1.47002675
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46633467
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.45301239
60* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44438745
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.44257937
62BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.43088751
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43025129
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.41100868
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40798107
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40798107
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40019363
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39637512
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39413728
70TCF4_22108803_ChIP-Seq_LS180_Human1.37960291
71AR_25329375_ChIP-Seq_VCAP_Human1.37385481
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.37149367
73SOX2_19829295_ChIP-Seq_ESCs_Human1.36394937
74NANOG_19829295_ChIP-Seq_ESCs_Human1.36394937
75KLF5_20875108_ChIP-Seq_MESCs_Mouse1.36197023
76RNF2_27304074_Chip-Seq_NSC_Mouse1.35226838
77TP53_18474530_ChIP-ChIP_U2OS_Human1.30197296
78* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.29784710
79HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29442359
80PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29079153
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.27314629
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25214833
83E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24759363
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24524643
85SOX2_21211035_ChIP-Seq_LN229_Gbm1.23009674
86* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22954318
87* FOXA1_25329375_ChIP-Seq_VCAP_Human1.22954318
88* IRF1_19129219_ChIP-ChIP_H3396_Human1.22852775
89SMAD4_21741376_ChIP-Seq_EPCs_Human1.22099303
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21433058
91TP53_16413492_ChIP-PET_HCT116_Human1.20725840
92CRX_20693478_ChIP-Seq_RETINA_Mouse1.17122204
93RING1B_27294783_Chip-Seq_ESCs_Mouse1.16121369
94RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15389135
95ER_23166858_ChIP-Seq_MCF-7_Human1.14872483
96* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14442249
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14210218
98TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13789469
99RUNX2_22187159_ChIP-Seq_PCA_Human1.13722137
100CDX2_22108803_ChIP-Seq_LS180_Human1.12878771
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12128854
102ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11753434
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.11563490
104PRDM14_20953172_ChIP-Seq_ESCs_Human1.11264762
105EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10738581
106JUN_21703547_ChIP-Seq_K562_Human1.10175299
107STAT3_23295773_ChIP-Seq_U87_Human1.09497507
108ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09448264
109SMAD_19615063_ChIP-ChIP_OVARY_Human1.08456497
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07666690
111CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07264444
112ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06972022
113TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06476230
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05252315
115* TCF4_23295773_ChIP-Seq_U87_Human1.05055615
116NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04802571
117MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04477544
118OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02974364
119AR_20517297_ChIP-Seq_VCAP_Human1.02662393
120* NCOR_22424771_ChIP-Seq_293T_Human1.02039251
121SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01133164
122GATA3_21878914_ChIP-Seq_MCF-7_Human0.99372634
123TAL1_26923725_Chip-Seq_HPCs_Mouse0.98556825
124SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98010497
125STAT3_18555785_Chip-Seq_ESCs_Mouse0.97602845
126BCAT_22108803_ChIP-Seq_LS180_Human0.97454077
127EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96673277
128CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96329011
129* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95672277
130ARNT_22903824_ChIP-Seq_MCF-7_Human0.95640926
131AR_19668381_ChIP-Seq_PC3_Human0.95429523
132EWS_26573619_Chip-Seq_HEK293_Human0.95079009
133PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93418803
134STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91260042
135TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91215776
136MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.91122583
137AHR_22903824_ChIP-Seq_MCF-7_Human0.89059686
138CMYC_18555785_Chip-Seq_ESCs_Mouse0.89014542
139FLI1_27457419_Chip-Seq_LIVER_Mouse0.88043855
140SMAD3_21741376_ChIP-Seq_ESCs_Human0.87953973
141KDM2B_26808549_Chip-Seq_REH_Human0.86905821
142E2F1_18555785_Chip-Seq_ESCs_Mouse0.86743008
143RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.84869675
144P53_22127205_ChIP-Seq_FIBROBLAST_Human0.83727799
145P53_22387025_ChIP-Seq_ESCs_Mouse0.83404248
146RING1B_27294783_Chip-Seq_NPCs_Mouse0.83370272

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern7.15473718
2MP0004859_abnormal_synaptic_plasticity4.55159444
3* MP0003635_abnormal_synaptic_transmissio3.70523022
4MP0003195_calcinosis3.65052298
5* MP0009745_abnormal_behavioral_response3.29282212
6MP0009046_muscle_twitch3.29068852
7MP0000569_abnormal_digit_pigmentation3.28150057
8MP0006276_abnormal_autonomic_nervous3.23026388
9MP0008877_abnormal_DNA_methylation3.06291976
10MP0002064_seizures3.04365286
11MP0002063_abnormal_learning/memory/cond2.96296996
12MP0001968_abnormal_touch/_nociception2.92981272
13MP0001440_abnormal_grooming_behavior2.86061983
14MP0001905_abnormal_dopamine_level2.83564439
15MP0002572_abnormal_emotion/affect_behav2.67397829
16MP0002736_abnormal_nociception_after2.65017957
17* MP0001529_abnormal_vocalization2.64798425
18MP0004270_analgesia2.52298008
19MP0005423_abnormal_somatic_nervous2.46538932
20MP0001501_abnormal_sleep_pattern2.46445679
21MP0002272_abnormal_nervous_system2.35806469
22MP0001486_abnormal_startle_reflex2.34133295
23MP0001986_abnormal_taste_sensitivity2.34014476
24MP0003122_maternal_imprinting2.22068148
25MP0004147_increased_porphyrin_level2.10846149
26MP0005645_abnormal_hypothalamus_physiol2.10675709
27MP0002822_catalepsy2.10093443
28MP0004142_abnormal_muscle_tone2.05375503
29* MP0004924_abnormal_behavior1.98468378
30* MP0005386_behavior/neurological_phenoty1.98468378
31MP0000372_irregular_coat_pigmentation1.98019543
32MP0002734_abnormal_mechanical_nocicepti1.93055312
33MP0003329_amyloid_beta_deposits1.86586528
34MP0002067_abnormal_sensory_capabilities1.86550731
35MP0006292_abnormal_olfactory_placode1.83636670
36MP0002138_abnormal_hepatobiliary_system1.81243024
37MP0002837_dystrophic_cardiac_calcinosis1.79869519
38MP0001970_abnormal_pain_threshold1.78330159
39MP0002184_abnormal_innervation1.72519129
40MP0002733_abnormal_thermal_nociception1.72121408
41MP0000427_abnormal_hair_cycle1.69738493
42MP0000778_abnormal_nervous_system1.67451735
43MP0002735_abnormal_chemical_nociception1.64067595
44MP0002557_abnormal_social/conspecific_i1.60564477
45MP0003252_abnormal_bile_duct1.59365699
46MP0002638_abnormal_pupillary_reflex1.56645610
47MP0002909_abnormal_adrenal_gland1.55129812
48MP0005174_abnormal_tail_pigmentation1.48527884
49MP0008875_abnormal_xenobiotic_pharmacok1.46595796
50MP0001485_abnormal_pinna_reflex1.44150104
51MP0005084_abnormal_gallbladder_morpholo1.43313041
52MP0004145_abnormal_muscle_electrophysio1.42122981
53MP0003136_yellow_coat_color1.40968979
54MP0003646_muscle_fatigue1.39292034
55MP0003718_maternal_effect1.37454620
56MP0002938_white_spotting1.36423090
57MP0002653_abnormal_ependyma_morphology1.35458612
58MP0002066_abnormal_motor_capabilities/c1.34184295
59MP0002882_abnormal_neuron_morphology1.26470283
60MP0008057_abnormal_DNA_replication1.24012729
61MP0005075_abnormal_melanosome_morpholog1.22736755
62MP0008872_abnormal_physiological_respon1.22559557
63MP0009780_abnormal_chondrocyte_physiolo1.21844054
64MP0005389_reproductive_system_phenotype1.20750042
65MP0004133_heterotaxia1.20488558
66MP0008058_abnormal_DNA_repair1.20464597
67MP0005646_abnormal_pituitary_gland1.20228486
68MP0000955_abnormal_spinal_cord1.20124042
69MP0005535_abnormal_body_temperature1.19541540
70MP0001984_abnormal_olfaction1.18480330
71MP0003698_abnormal_male_reproductive1.18362228
72MP0002928_abnormal_bile_duct1.17101862
73MP0001188_hyperpigmentation1.16985147
74MP0001502_abnormal_circadian_rhythm1.16741393
75MP0000751_myopathy1.15036973
76MP0002160_abnormal_reproductive_system1.13242665
77MP0004742_abnormal_vestibular_system1.12430062
78MP0002751_abnormal_autonomic_nervous1.12281136
79MP0001929_abnormal_gametogenesis1.11066811
80MP0008569_lethality_at_weaning1.11000993
81MP0005409_darkened_coat_color1.09586892
82MP0000631_abnormal_neuroendocrine_gland1.07450810
83MP0004811_abnormal_neuron_physiology1.06873899
84MP0004043_abnormal_pH_regulation1.06742107
85MP0006072_abnormal_retinal_apoptosis1.05480602
86MP0000647_abnormal_sebaceous_gland1.04985865
87MP0003011_delayed_dark_adaptation1.04126255
88MP0005551_abnormal_eye_electrophysiolog1.04006801
89MP0000383_abnormal_hair_follicle1.03802521
90MP0009697_abnormal_copulation1.03453014
91MP0002876_abnormal_thyroid_physiology1.01313153
92MP0010386_abnormal_urinary_bladder1.00226950
93MP0002229_neurodegeneration0.97912229
94MP0003690_abnormal_glial_cell0.97836324
95MP0002163_abnormal_gland_morphology0.96973182
96MP0005410_abnormal_fertilization0.96456907
97MP0000604_amyloidosis0.96006601
98MP0002095_abnormal_skin_pigmentation0.95702770
99MP0000920_abnormal_myelination0.94353211
100MP0006035_abnormal_mitochondrial_morpho0.94302347
101MP0002152_abnormal_brain_morphology0.93164422
102MP0008874_decreased_physiological_sensi0.90986611
103MP0005167_abnormal_blood-brain_barrier0.90084338
104MP0000538_abnormal_urinary_bladder0.89249355
105MP0002210_abnormal_sex_determination0.89052844
106MP0001727_abnormal_embryo_implantation0.87904299
107MP0002090_abnormal_vision0.87352534
108* MP0002069_abnormal_eating/drinking_beha0.86997676
109MP0000653_abnormal_sex_gland0.86846274
110MP0004885_abnormal_endolymph0.86800647
111MP0000015_abnormal_ear_pigmentation0.86678547
112* MP0001664_abnormal_digestion0.86319911
113MP0006054_spinal_hemorrhage0.85970588
114MP0003631_nervous_system_phenotype0.83943312
115MP0005085_abnormal_gallbladder_physiolo0.83365827
116MP0004484_altered_response_of0.82631626
117MP0003633_abnormal_nervous_system0.81810930
118MP0005195_abnormal_posterior_eye0.81651876
119MP0001963_abnormal_hearing_physiology0.81618752
120MP0005623_abnormal_meninges_morphology0.80416471
121MP0003634_abnormal_glial_cell0.78884646
122MP0000639_abnormal_adrenal_gland0.78284516
123MP0003632_abnormal_nervous_system0.77941645
124MP0004858_abnormal_nervous_system0.77916693
125MP0003121_genomic_imprinting0.77799307
126MP0001324_abnormal_eye_pigmentation0.77424144
127MP0001145_abnormal_male_reproductive0.77353006
128MP0002693_abnormal_pancreas_physiology0.77148932
129MP0001919_abnormal_reproductive_system0.76494416
130MP0008995_early_reproductive_senescence0.75923295
131MP0002752_abnormal_somatic_nervous0.75127174
132MP0000230_abnormal_systemic_arterial0.73972422
133MP0005187_abnormal_penis_morphology0.73842552
134MP0002234_abnormal_pharynx_morphology0.72477554
135MP0010678_abnormal_skin_adnexa0.72184865
136MP0004085_abnormal_heartbeat0.72184299
137MP0005379_endocrine/exocrine_gland_phen0.68237143
138MP0003283_abnormal_digestive_organ0.67273823
139MP0002102_abnormal_ear_morphology0.66197627
140MP0005394_taste/olfaction_phenotype0.65801090
141MP0005499_abnormal_olfactory_system0.65801090
142MP0000747_muscle_weakness0.64949220
143MP0005253_abnormal_eye_physiology0.64209664
144MP0003123_paternal_imprinting0.64016980
145MP0002139_abnormal_hepatobiliary_system0.62932628
146MP0000013_abnormal_adipose_tissue0.61772734
147MP0000026_abnormal_inner_ear0.59799171
148MP0010234_abnormal_vibrissa_follicle0.59687986
149MP0003787_abnormal_imprinting0.59612934
150MP0001943_abnormal_respiration0.59459066
151MP0003879_abnormal_hair_cell0.56491875
152MP0001299_abnormal_eye_distance/0.53683237

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.89680319
2Visual hallucinations (HP:0002367)6.59727967
3Limb dystonia (HP:0002451)5.44358390
4Cerebral inclusion bodies (HP:0100314)5.25739231
5Focal seizures (HP:0007359)4.79275297
6Myokymia (HP:0002411)4.70878332
7Neurofibrillary tangles (HP:0002185)4.60847035
8Atonic seizures (HP:0010819)4.40250295
9Absence seizures (HP:0002121)4.33728250
10Pancreatic cysts (HP:0001737)4.32580495
11Generalized tonic-clonic seizures (HP:0002069)3.95102242
12Pancreatic fibrosis (HP:0100732)3.90570156
13True hermaphroditism (HP:0010459)3.90475500
14Progressive cerebellar ataxia (HP:0002073)3.86795854
15Dialeptic seizures (HP:0011146)3.83270214
16Acute necrotizing encephalopathy (HP:0006965)3.80982266
17Medial flaring of the eyebrow (HP:0010747)3.62763097
18Supranuclear gaze palsy (HP:0000605)3.53798290
19Abnormal mitochondria in muscle tissue (HP:0008316)3.41586796
20Febrile seizures (HP:0002373)3.37997705
21Nephronophthisis (HP:0000090)3.33309365
22Attenuation of retinal blood vessels (HP:0007843)3.31984067
23Progressive macrocephaly (HP:0004481)3.28021172
24Type II lissencephaly (HP:0007260)3.27441063
25Pheochromocytoma (HP:0002666)3.22671273
26Congenital stationary night blindness (HP:0007642)3.21301562
27Epileptic encephalopathy (HP:0200134)3.18640324
28Anxiety (HP:0000739)3.15258282
29Mitochondrial inheritance (HP:0001427)3.10192088
30Truncal ataxia (HP:0002078)3.05015871
31Chronic hepatic failure (HP:0100626)3.04525206
32Acute encephalopathy (HP:0006846)3.00818147
33Broad-based gait (HP:0002136)2.94367867
34Hyperventilation (HP:0002883)2.93219837
35Abnormality of the renal medulla (HP:0100957)2.93201250
36Delusions (HP:0000746)2.91067520
37Abolished electroretinogram (ERG) (HP:0000550)2.85549940
38Neuroendocrine neoplasm (HP:0100634)2.84661339
39Congenital primary aphakia (HP:0007707)2.82673404
40Intestinal atresia (HP:0011100)2.79534869
41Abnormality of the renal cortex (HP:0011035)2.79434896
42Drooling (HP:0002307)2.76828572
43Excessive salivation (HP:0003781)2.76828572
44Polyphagia (HP:0002591)2.73270831
45Cystic liver disease (HP:0006706)2.71848431
46Cerebral hemorrhage (HP:0001342)2.70751664
47Infantile muscular hypotonia (HP:0008947)2.70389473
48Increased hepatocellular lipid droplets (HP:0006565)2.69366086
49Bony spicule pigmentary retinopathy (HP:0007737)2.67819023
50Cerebellar dysplasia (HP:0007033)2.67325633
51Psychosis (HP:0000709)2.66659665
52Absent speech (HP:0001344)2.63283087
53Abnormality of the corticospinal tract (HP:0002492)2.61783899
54Failure to thrive in infancy (HP:0001531)2.56922101
55Abnormal rod and cone electroretinograms (HP:0008323)2.56228491
56Dysmetria (HP:0001310)2.55205234
57Facial shape deformation (HP:0011334)2.54626223
58Potter facies (HP:0002009)2.54626223
59Insidious onset (HP:0003587)2.53997218
60Termporal pattern (HP:0011008)2.53997218
61Increased CSF lactate (HP:0002490)2.52731605
62Abnormality of binocular vision (HP:0011514)2.51259823
63Diplopia (HP:0000651)2.51259823
64Hypoventilation (HP:0002791)2.50665615
65Pendular nystagmus (HP:0012043)2.50372707
66Thyroid-stimulating hormone excess (HP:0002925)2.50304813
67Aplasia/Hypoplasia of the tongue (HP:0010295)2.49369596
68Nephrogenic diabetes insipidus (HP:0009806)2.47315487
69Agitation (HP:0000713)2.47169575
70Degeneration of the lateral corticospinal tracts (HP:0002314)2.46748152
71Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.46748152
72Genetic anticipation (HP:0003743)2.44853806
73Inability to walk (HP:0002540)2.42764798
74Genital tract atresia (HP:0001827)2.42304003
75Action tremor (HP:0002345)2.40856806
76Depression (HP:0000716)2.38078553
77Bradykinesia (HP:0002067)2.37661937
78Abnormal eating behavior (HP:0100738)2.37140008
79Stomach cancer (HP:0012126)2.36291910
80Decreased central vision (HP:0007663)2.32863278
81Progressive inability to walk (HP:0002505)2.32164996
82Hypokinesia (HP:0002375)2.32039051
83Rapidly progressive (HP:0003678)2.31806959
84Tubular atrophy (HP:0000092)2.31307992
85Aplasia/Hypoplasia of the tibia (HP:0005772)2.28573337
86Vaginal atresia (HP:0000148)2.27146745
87Sensory axonal neuropathy (HP:0003390)2.26536469
88Epileptiform EEG discharges (HP:0011182)2.25956854
89Optic disc pallor (HP:0000543)2.25260107
90Abnormality of macular pigmentation (HP:0008002)2.24875093
91Abnormal biliary tract physiology (HP:0012439)2.24464699
92Bile duct proliferation (HP:0001408)2.24464699
93Generalized myoclonic seizures (HP:0002123)2.21948844
94Sclerocornea (HP:0000647)2.21781746
95Mutism (HP:0002300)2.20712309
96Poor suck (HP:0002033)2.19406434
97Retinal dysplasia (HP:0007973)2.18657866
98Abnormality of alanine metabolism (HP:0010916)2.18618432
99Hyperalaninemia (HP:0003348)2.18618432
100Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.18618432
101Lipid accumulation in hepatocytes (HP:0006561)2.17648957
102Delayed gross motor development (HP:0002194)2.16955758
103Cerebral edema (HP:0002181)2.16831716
104Hemiparesis (HP:0001269)2.16490675
105Diminished movement (HP:0002374)2.16442739
106Postural tremor (HP:0002174)2.16186247
107Hepatocellular necrosis (HP:0001404)2.14798154
108EEG with generalized epileptiform discharges (HP:0011198)2.13757240
109Keratoconus (HP:0000563)2.13393168
110Increased corneal curvature (HP:0100692)2.13393168
111Lissencephaly (HP:0001339)2.13109698
112Abnormal pupillary function (HP:0007686)2.12579424
113Amblyopia (HP:0000646)2.11012017
114Impaired vibration sensation in the lower limbs (HP:0002166)2.10788060
115Renal Fanconi syndrome (HP:0001994)2.10209218
116Rigidity (HP:0002063)2.08140127
117Poor coordination (HP:0002370)2.07494616
118Poor eye contact (HP:0000817)2.07459547
119Chronic otitis media (HP:0000389)2.06821493
120Congenital hepatic fibrosis (HP:0002612)2.06481343
121Scanning speech (HP:0002168)2.06305694
122Gait imbalance (HP:0002141)2.05447294
123Abnormality of the parathyroid morphology (HP:0011766)2.04545325
124Dysdiadochokinesis (HP:0002075)2.04002282
125Esotropia (HP:0000565)2.03676295
126Morphological abnormality of the pyramidal tract (HP:0002062)2.03588069
127Congenital sensorineural hearing impairment (HP:0008527)2.02786467
128Testicular neoplasm (HP:0010788)2.02417138
129Furrowed tongue (HP:0000221)2.02322987
130Leukodystrophy (HP:0002415)2.01643494
131Male pseudohermaphroditism (HP:0000037)1.99981147
132Hypothermia (HP:0002045)1.97947723
133Clumsiness (HP:0002312)1.96874256
134Postaxial foot polydactyly (HP:0001830)1.96129459
135Large for gestational age (HP:0001520)1.95807482
136Molar tooth sign on MRI (HP:0002419)1.95728328
137Abnormality of midbrain morphology (HP:0002418)1.95728328
138Occipital encephalocele (HP:0002085)1.95305623
139Ketoacidosis (HP:0001993)1.94476349
140Hypsarrhythmia (HP:0002521)1.94100954
141Retinitis pigmentosa (HP:0000510)1.93807248
142Anencephaly (HP:0002323)1.93716449
143Abnormal drinking behavior (HP:0030082)1.93426568
144Polydipsia (HP:0001959)1.93426568
145Widely spaced teeth (HP:0000687)1.92605050
146Astigmatism (HP:0000483)1.91402247
147Renal cortical cysts (HP:0000803)1.91250252
148Gaze-evoked nystagmus (HP:0000640)1.90849848
149Exotropia (HP:0000577)1.90499661
150Restlessness (HP:0000711)1.89896782
151Disproportionate short-trunk short stature (HP:0003521)1.89787768
152Optic nerve hypoplasia (HP:0000609)1.89759567
153X-linked dominant inheritance (HP:0001423)1.89474205
154Urinary bladder sphincter dysfunction (HP:0002839)1.88989971
155Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88957290
156Blue irides (HP:0000635)1.88725489
157Postaxial hand polydactyly (HP:0001162)1.87634596
158Impaired social interactions (HP:0000735)1.86411256
159Abnormal social behavior (HP:0012433)1.86411256
160Myoclonus (HP:0001336)1.86087268
161Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.84425661
162Abnormal ciliary motility (HP:0012262)1.84321312
163CNS hypomyelination (HP:0003429)1.83723676
164Amelogenesis imperfecta (HP:0000705)1.83562181
165Abnormality of the labia minora (HP:0012880)1.83544791
166Postural instability (HP:0002172)1.83123382
167Thyroiditis (HP:0100646)1.79326092
168Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79178289
169Dynein arm defect of respiratory motile cilia (HP:0012255)1.78976282
170Absent/shortened dynein arms (HP:0200106)1.78976282
171Abnormality of the pons (HP:0007361)1.77918662
172Protruding tongue (HP:0010808)1.77680053
173Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74035249
174Constricted visual fields (HP:0001133)1.73669568
175Hypoplasia of the pons (HP:0012110)1.73348553
176Chorioretinal atrophy (HP:0000533)1.71907230
177Concave nail (HP:0001598)1.71314397
178Polyuria (HP:0000103)1.70250284
1793-Methylglutaconic aciduria (HP:0003535)1.70056146
180Preaxial hand polydactyly (HP:0001177)1.68437832
181Volvulus (HP:0002580)1.67162035
182Severe muscular hypotonia (HP:0006829)1.67047626
183Fair hair (HP:0002286)1.65772095
184Severe visual impairment (HP:0001141)1.65671510
185Tubulointerstitial nephritis (HP:0001970)1.65547180
186Oculomotor apraxia (HP:0000657)1.64863367

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.10633465
2MAP3K123.64120394
3NTRK33.61696026
4PNCK3.55709329
5EPHA42.94602620
6MAP4K22.91298177
7MAP3K92.88016323
8WNK32.69838867
9MARK12.55444785
10MAP3K42.51382534
11MINK12.46624165
12INSRR2.45721917
13NUAK12.32096065
14TRIM282.31990194
15PLK22.29149147
16TAOK32.27524061
17GRK52.26709489
18ACVR1B2.23245026
19PINK12.13099223
20CASK2.11060442
21MAP2K42.04600270
22GRK71.97439321
23FGR1.95670626
24NTRK11.89812038
25FES1.88156439
26CSNK1G31.82184556
27MAP2K71.81833434
28GRK11.81238751
29PTK2B1.78146281
30ARAF1.75508926
31MAPKAPK51.73496109
32NTRK21.71583490
33CSNK1G21.71149746
34RIPK41.69706638
35SIK21.68550697
36GRK61.66710615
37CAMK2A1.57767551
38ZAK1.55908688
39KSR21.53794621
40TLK11.49342204
41MAP3K131.42231664
42CAMK2B1.35578757
43CDK51.35449214
44LATS21.35273641
45TNK21.33115146
46NME11.32669428
47ADRBK21.30895709
48STK38L1.29376918
49TNIK1.26682054
50KSR11.25088218
51STK391.22931883
52CSNK1G11.19550658
53PAK31.13718874
54BCR1.13526275
55CAMK2D1.12661586
56MST41.11466297
57MKNK21.10953760
58TXK1.10555975
59CAMKK21.10106507
60MAPK131.09868712
61RET1.08961754
62OXSR11.08088098
63PRKCG1.05267299
64CDK191.04610403
65PAK61.02803298
66DAPK21.01300846
67EIF2AK30.98263249
68DAPK10.98252587
69FER0.97152875
70CAMKK10.91090534
71ERBB30.89854336
72UHMK10.89031937
73WNK40.88157800
74ADRBK10.87978893
75DYRK1A0.86608114
76CAMK1G0.85728701
77BRSK20.84733376
78LATS10.78597068
79CDK140.78215744
80BMPR20.77200649
81CAMK2G0.76647316
82TSSK60.76586358
83FGFR20.76234849
84STK30.72551783
85CDK180.72227541
86PIK3CG0.71607696
87MAP3K20.71472009
88CDK150.71405523
89TGFBR10.69124685
90TEC0.68405179
91ROCK20.68198475
92PIK3CA0.67474285
93PLK40.67375109
94PRKCE0.66502022
95DYRK20.60823954
96CDK11A0.58473046
97IKBKB0.58363997
98IRAK10.58230338
99VRK10.57872571
100RAF10.57260006
101PHKG10.56972747
102PHKG20.56972747
103MOS0.56888632
104FYN0.54638271
105MKNK10.54511149
106STK110.53962441
107SGK10.52606720
108PBK0.51216308
109PLK30.50678235
110STK380.50607208
111AKT30.50465538
112EPHB20.49421520
113CSNK1A1L0.47160282
114MYLK0.46922513
115PRKACA0.46063790
116CHUK0.45754417
117CAMK10.44746826
118NLK0.43603557
119MARK30.43544395
120PKN10.42763546
121MAP3K70.42369869
122PRKAA20.42230493
123CSNK1D0.41975037
124DYRK30.41013791
125CSNK1E0.40218771
126NEK60.39576727
127PRKCQ0.37915242
128MARK20.37836886
129PRPF4B0.36735317
130PRKCZ0.35964710
131BMPR1B0.35200628
132MAP2K10.34203794
133PRKG10.34040259
134PRKCA0.33506946
135SGK20.33394236
136MUSK0.33137329
137PRKCH0.32783418
138SIK30.32039380
139PRKCB0.31314664
140MAPK100.31072019
141MAPK150.30291956
142BRD40.30283929
143PTK20.29962560
144PRKAA10.29704546
145STK160.29291562
146FLT30.29251702
147CSNK1A10.28168634
148ABL10.28061689
149SYK0.27422784
150OBSCN0.27109148
151SRC0.26786219

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.62101045
2Oxidative phosphorylation_Homo sapiens_hsa001903.46155032
3Synaptic vesicle cycle_Homo sapiens_hsa047213.09214955
4Parkinsons disease_Homo sapiens_hsa050122.95899257
5Amphetamine addiction_Homo sapiens_hsa050312.79439922
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.76038910
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.61999685
8Linoleic acid metabolism_Homo sapiens_hsa005912.60925707
9GABAergic synapse_Homo sapiens_hsa047272.59973681
10Collecting duct acid secretion_Homo sapiens_hsa049662.51025286
11Alzheimers disease_Homo sapiens_hsa050102.50960127
12Cocaine addiction_Homo sapiens_hsa050302.50483687
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.31790623
14Long-term potentiation_Homo sapiens_hsa047202.28118993
15Morphine addiction_Homo sapiens_hsa050322.27774715
16Glutamatergic synapse_Homo sapiens_hsa047242.26913485
17Maturity onset diabetes of the young_Homo sapiens_hsa049502.22580004
18Dopaminergic synapse_Homo sapiens_hsa047282.21028110
19Circadian entrainment_Homo sapiens_hsa047132.17951332
20Serotonergic synapse_Homo sapiens_hsa047262.09707682
21Olfactory transduction_Homo sapiens_hsa047402.05352142
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.01801019
23Taste transduction_Homo sapiens_hsa047422.01384199
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.98018455
25Cardiac muscle contraction_Homo sapiens_hsa042601.93704105
26Homologous recombination_Homo sapiens_hsa034401.90661549
27Ether lipid metabolism_Homo sapiens_hsa005651.89950345
28Basal transcription factors_Homo sapiens_hsa030221.81835849
29ABC transporters_Homo sapiens_hsa020101.79154918
30Huntingtons disease_Homo sapiens_hsa050161.77522991
31Selenocompound metabolism_Homo sapiens_hsa004501.76940182
32Tryptophan metabolism_Homo sapiens_hsa003801.74642674
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.74568821
34Salivary secretion_Homo sapiens_hsa049701.74350838
35Renin secretion_Homo sapiens_hsa049241.72167009
36* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.70895651
37Long-term depression_Homo sapiens_hsa047301.65232510
38Vibrio cholerae infection_Homo sapiens_hsa051101.61493389
39Insulin secretion_Homo sapiens_hsa049111.57176178
40Fanconi anemia pathway_Homo sapiens_hsa034601.55131044
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.53831402
42Gastric acid secretion_Homo sapiens_hsa049711.45480422
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45264649
44Caffeine metabolism_Homo sapiens_hsa002321.44811408
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.43448935
46* Calcium signaling pathway_Homo sapiens_hsa040201.42702137
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.42218904
48* Cholinergic synapse_Homo sapiens_hsa047251.38499283
49Oxytocin signaling pathway_Homo sapiens_hsa049211.38451266
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.37565747
51Phototransduction_Homo sapiens_hsa047441.31578804
52Aldosterone synthesis and secretion_Homo sapiens_hsa049251.30683906
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.27419324
54Retinol metabolism_Homo sapiens_hsa008301.26370699
55Protein export_Homo sapiens_hsa030601.25909328
56Chemical carcinogenesis_Homo sapiens_hsa052041.18254176
57GnRH signaling pathway_Homo sapiens_hsa049121.16640260
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.15915712
59Peroxisome_Homo sapiens_hsa041461.14792868
60Arachidonic acid metabolism_Homo sapiens_hsa005901.14412453
61Axon guidance_Homo sapiens_hsa043601.13991483
62RNA polymerase_Homo sapiens_hsa030201.10129836
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09451160
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08301819
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06239024
66Gap junction_Homo sapiens_hsa045401.03898610
67RNA degradation_Homo sapiens_hsa030180.98615793
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98290168
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94058231
70cAMP signaling pathway_Homo sapiens_hsa040240.89526812
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89249897
72Regulation of autophagy_Homo sapiens_hsa041400.88389531
73Estrogen signaling pathway_Homo sapiens_hsa049150.85861675
74Non-homologous end-joining_Homo sapiens_hsa034500.83918675
75Fatty acid degradation_Homo sapiens_hsa000710.82679054
76Fatty acid metabolism_Homo sapiens_hsa012120.81883536
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.80000035
78beta-Alanine metabolism_Homo sapiens_hsa004100.79699946
79Melanogenesis_Homo sapiens_hsa049160.78467764
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76417040
81Dorso-ventral axis formation_Homo sapiens_hsa043200.75678598
82Rheumatoid arthritis_Homo sapiens_hsa053230.75347839
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71491713
84Oocyte meiosis_Homo sapiens_hsa041140.71232346
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.71167560
86Sphingolipid metabolism_Homo sapiens_hsa006000.68905679
87Prion diseases_Homo sapiens_hsa050200.68606588
88Glycerolipid metabolism_Homo sapiens_hsa005610.67778574
89Circadian rhythm_Homo sapiens_hsa047100.65852284
90Fatty acid biosynthesis_Homo sapiens_hsa000610.65776530
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64278507
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63546268
93Fat digestion and absorption_Homo sapiens_hsa049750.62165898
94Alcoholism_Homo sapiens_hsa050340.59811037
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59180615
96Dilated cardiomyopathy_Homo sapiens_hsa054140.59174866
97Steroid biosynthesis_Homo sapiens_hsa001000.57195852
98Metabolic pathways_Homo sapiens_hsa011000.56261829
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55743021
100Purine metabolism_Homo sapiens_hsa002300.55613862
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55517495
102Pancreatic secretion_Homo sapiens_hsa049720.51523929
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51446288
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48919657
105Phagosome_Homo sapiens_hsa041450.47439960
106Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47347055
107Thyroid hormone synthesis_Homo sapiens_hsa049180.46562730
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45979504
109African trypanosomiasis_Homo sapiens_hsa051430.44366402
110Glucagon signaling pathway_Homo sapiens_hsa049220.44304645
111Histidine metabolism_Homo sapiens_hsa003400.44287303
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42653117
113ErbB signaling pathway_Homo sapiens_hsa040120.39441596
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39094752
115Pyruvate metabolism_Homo sapiens_hsa006200.38420969
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.38417519
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37915577
118Bile secretion_Homo sapiens_hsa049760.37749431
119MAPK signaling pathway_Homo sapiens_hsa040100.37711680
120Type II diabetes mellitus_Homo sapiens_hsa049300.37572525
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37106287
122Glioma_Homo sapiens_hsa052140.36525296
123Butanoate metabolism_Homo sapiens_hsa006500.36509249
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.36181170
125Choline metabolism in cancer_Homo sapiens_hsa052310.36003821
126Tyrosine metabolism_Homo sapiens_hsa003500.34169434
127Fatty acid elongation_Homo sapiens_hsa000620.32418562
128Phenylalanine metabolism_Homo sapiens_hsa003600.32160067
129Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31803506
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31344085
131Sulfur metabolism_Homo sapiens_hsa009200.29899882
132Ras signaling pathway_Homo sapiens_hsa040140.29520844
133Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.29155571
134Ovarian steroidogenesis_Homo sapiens_hsa049130.29107074
135Mineral absorption_Homo sapiens_hsa049780.28996956
136Nitrogen metabolism_Homo sapiens_hsa009100.28158113
137Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27707042
138Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27640542
139Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26370892
140Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.25039441
141Rap1 signaling pathway_Homo sapiens_hsa040150.23395113
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.23297280
143Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.22720443
144Propanoate metabolism_Homo sapiens_hsa006400.22491886
145Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22431762
146Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.21708188
147Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20663134
148VEGF signaling pathway_Homo sapiens_hsa043700.20127953
149Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.17419906
150Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.16963373
151Inositol phosphate metabolism_Homo sapiens_hsa005620.14375186
152Sphingolipid signaling pathway_Homo sapiens_hsa040710.14126301
153Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.14094893
154Renal cell carcinoma_Homo sapiens_hsa052110.13227257
155Type I diabetes mellitus_Homo sapiens_hsa049400.12900232

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