CHRNA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The muscle acetylcholine receptor consiststs of 5 subunits of 4 different types: 2 alpha subunits and 1 each of the beta, gamma, and delta subunits. This gene encodes an alpha subunit that plays a role in acetlycholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of myotube differentiation (GO:0010831)9.98791096
2actin-myosin filament sliding (GO:0033275)9.82130860
3muscle filament sliding (GO:0030049)9.82130860
4response to inactivity (GO:0014854)9.67880536
5striated muscle atrophy (GO:0014891)9.17102896
6response to stimulus involved in regulation of muscle adaptation (GO:0014874)8.46345237
7* skeletal muscle contraction (GO:0003009)8.44209637
8positive regulation of skeletal muscle tissue development (GO:0048643)8.35759513
9actin-mediated cell contraction (GO:0070252)8.32068807
10muscle atrophy (GO:0014889)8.20704129
11positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)7.80902838
12myoblast fusion (GO:0007520)7.50316812
13heart process (GO:0003015)7.03767262
14heart contraction (GO:0060047)7.03767262
15positive regulation of myoblast differentiation (GO:0045663)6.96028869
16cellular response to estradiol stimulus (GO:0071392)6.81904454
17plasma membrane repair (GO:0001778)6.80637386
18syncytium formation by plasma membrane fusion (GO:0000768)6.75590718
19negative regulation of nitric-oxide synthase activity (GO:0051001)6.56232552
20membrane raft organization (GO:0031579)6.25003498
21syncytium formation (GO:0006949)6.21510683
22muscle fiber development (GO:0048747)6.12824267
23myotube differentiation (GO:0014902)6.11115145
24cardiac myofibril assembly (GO:0055003)6.09599779
25actin filament-based movement (GO:0030048)6.04351746
26skeletal muscle tissue development (GO:0007519)5.94867883
27response to muscle activity (GO:0014850)5.91512577
28* muscle cell cellular homeostasis (GO:0046716)5.88157204
29regulation of skeletal muscle contraction (GO:0014819)5.61914240
30response to gravity (GO:0009629)5.42059706
31mRNA transcription from RNA polymerase II promoter (GO:0042789)5.25994017
32sarcoplasmic reticulum calcium ion transport (GO:0070296)5.19181111
33muscle tissue morphogenesis (GO:0060415)5.05129703
34regulation of integrin-mediated signaling pathway (GO:2001044)5.03380899
35muscle organ development (GO:0007517)4.92851668
36sarcomere organization (GO:0045214)4.90238299
37positive regulation of striated muscle cell differentiation (GO:0051155)4.79106476
38muscle structure development (GO:0061061)4.79105005
39negative regulation of muscle hypertrophy (GO:0014741)4.74113812
40membrane assembly (GO:0071709)4.73408116
41regulation of myotube differentiation (GO:0010830)4.60456879
42regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.59770148
43cellular response to estrogen stimulus (GO:0071391)4.51492638
44striated muscle cell development (GO:0055002)4.50091451
45mRNA transcription (GO:0009299)4.44579185
46regulation of myoblast differentiation (GO:0045661)4.40558360
47skeletal muscle tissue regeneration (GO:0043403)4.38130697
48embryonic camera-type eye development (GO:0031076)4.27271497
49positive regulation of muscle cell differentiation (GO:0051149)4.27050405
50regulation of striated muscle contraction (GO:0006942)4.22984466
51regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.15647291
52negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.14547602
53regulation of metalloenzyme activity (GO:0048552)4.10268577
54cardiac muscle contraction (GO:0060048)4.08811440
55muscle cell development (GO:0055001)4.06680188
56peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.06262808
57plasma membrane fusion (GO:0045026)3.99941734
58striated muscle adaptation (GO:0014888)3.97843704
59regulation of protein heterodimerization activity (GO:0043497)3.96357319
60striated muscle tissue development (GO:0014706)3.95049252
61actin filament depolymerization (GO:0030042)3.94501956
62postsynaptic membrane organization (GO:0001941)3.93074542
63negative regulation of monooxygenase activity (GO:0032769)3.92461508
64cardiac muscle tissue morphogenesis (GO:0055008)3.85199819
65* striated muscle contraction (GO:0006941)3.72024058
66regulation of skeletal muscle cell differentiation (GO:2001014)3.66642969
67regulation of skeletal muscle fiber development (GO:0048742)3.65196041
68* musculoskeletal movement (GO:0050881)3.64733361
69* multicellular organismal movement (GO:0050879)3.64733361
70* muscle contraction (GO:0006936)3.59843580
71regulation of membrane repolarization (GO:0060306)3.58181735
72positive regulation of protein homodimerization activity (GO:0090073)3.54360683
73muscle tissue development (GO:0060537)3.52238670
74regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.49108615
75actomyosin structure organization (GO:0031032)3.44141939
76regulation of skeletal muscle tissue development (GO:0048641)3.43021769
77cardiac muscle cell development (GO:0055013)3.42615681
78negative regulation of cell size (GO:0045792)3.36741352
79positive regulation of protein depolymerization (GO:1901881)3.35414449
80* muscle system process (GO:0003012)3.32808896
81positive regulation of muscle organ development (GO:0048636)3.28105364
82positive regulation of striated muscle tissue development (GO:0045844)3.28105364
83regulation of sarcomere organization (GO:0060297)3.27939063
84regulation of muscle cell differentiation (GO:0051147)3.27234528
85muscle adaptation (GO:0043500)3.26931352
86regulation of cardiac muscle cell differentiation (GO:2000725)3.25444080
87regulation of striated muscle cell differentiation (GO:0051153)3.19503146
88negative regulation of skeletal muscle tissue development (GO:0048642)3.18724964
89negative regulation of gluconeogenesis (GO:0045721)3.18167254
90positive regulation of muscle tissue development (GO:1901863)3.17441572
91skeletal muscle cell differentiation (GO:0035914)3.14673370
92cardiac cell development (GO:0055006)3.09720875
93cellular response to lithium ion (GO:0071285)3.08795863
94cell aggregation (GO:0098743)3.07557598
95cartilage condensation (GO:0001502)3.07557598
96regulation of alkaline phosphatase activity (GO:0010692)3.06148036
97regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.06126485
98negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.05930618
99cellular response to dexamethasone stimulus (GO:0071549)3.05733476
100positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.05282203
101somitogenesis (GO:0001756)3.02525381
102activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.99551306
103regulation of muscle system process (GO:0090257)2.95843631
104regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.93404507
105myoblast migration (GO:0051451)2.93353111
106negative regulation of heart growth (GO:0061117)2.92863690
107negative regulation of cardiac muscle tissue growth (GO:0055022)2.92863690
108negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.91665313
109regulation of action potential (GO:0098900)2.89774566
110response to lithium ion (GO:0010226)2.87501158
111regulation of muscle contraction (GO:0006937)2.86242975
112regulation of muscle hypertrophy (GO:0014743)2.86195673
113metanephric mesenchyme development (GO:0072075)2.79821777
114negative regulation of potassium ion transmembrane transport (GO:1901380)2.78396917
115muscle cell differentiation (GO:0042692)2.72328662
116germinal center formation (GO:0002467)2.68701916
117regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.68316665
118embryonic retina morphogenesis in camera-type eye (GO:0060059)2.65874697
119behavioral response to nicotine (GO:0035095)2.64062717
120face morphogenesis (GO:0060325)2.61897907
121negative regulation of protein localization to cell surface (GO:2000009)2.57725207
122sequestering of actin monomers (GO:0042989)2.57285808
123skeletal muscle adaptation (GO:0043501)2.51393515
124cranial nerve morphogenesis (GO:0021602)2.49960311
125myofibril assembly (GO:0030239)2.49216976
126positive regulation of astrocyte differentiation (GO:0048711)2.46291641
127synaptic transmission, cholinergic (GO:0007271)2.45710393
128proteasome assembly (GO:0043248)2.45595994
129positive regulation of protein complex disassembly (GO:0043243)2.42869234
130regulation of muscle adaptation (GO:0043502)2.42169910
131positive regulation of cell cycle arrest (GO:0071158)2.41813716
132regulation of secondary heart field cardioblast proliferation (GO:0003266)2.41284350
133regulation of cardioblast proliferation (GO:0003264)2.41284350
134kidney mesenchyme development (GO:0072074)2.40869370
135organ induction (GO:0001759)2.40560005
136regulation of cell communication by electrical coupling (GO:0010649)2.37850095
137positive regulation of gastrulation (GO:2000543)2.24446214
138regulation of cell cycle arrest (GO:0071156)2.24285196
139heterotypic cell-cell adhesion (GO:0034113)2.24281510
140muscle cell fate commitment (GO:0042693)13.5889206
141skeletal muscle fiber development (GO:0048741)12.2183731
142myotube cell development (GO:0014904)10.4683422
143regulation of syncytium formation by plasma membrane fusion (GO:0060142)10.3115106

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.41723607
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.37917576
3ZNF652_21678463_ChIP-ChIP_ZR75-1_Human3.42661503
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.39081889
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.38709814
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.03166432
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.96592389
8ESR1_20079471_ChIP-ChIP_T-47D_Human2.95313644
9GATA1_22025678_ChIP-Seq_K562_Human2.89725245
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.85715022
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.80597140
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.79103698
13WT1_19549856_ChIP-ChIP_CCG9911_Human2.67597989
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.65783905
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.60486704
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.45173140
17MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.44037435
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.38796628
19EP300_21415370_ChIP-Seq_HL-1_Mouse2.32651491
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.28554880
21CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.21524861
22TP63_17297297_ChIP-ChIP_HaCaT_Human2.16687515
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.16122369
24NFE2_27457419_Chip-Seq_LIVER_Mouse2.15574818
25CDX2_19796622_ChIP-Seq_MESCs_Mouse2.13577352
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.13395303
27ELK1_19687146_ChIP-ChIP_HELA_Human2.09179082
28ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06926478
29ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.96552849
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.96436095
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.92863110
32SUZ12_27294783_Chip-Seq_NPCs_Mouse1.88045278
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.87943351
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86843976
35ZNF274_21170338_ChIP-Seq_K562_Hela1.85738591
36ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.84871752
37ELK1_22589737_ChIP-Seq_MCF10A_Human1.83805648
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82626045
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.81762181
40E2F7_22180533_ChIP-Seq_HELA_Human1.79032660
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77813474
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.75959622
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.70032047
44* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.69731610
45SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.65616396
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.62000645
47MYC_19030024_ChIP-ChIP_MESCs_Mouse1.60070411
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.59671968
49DCP1A_22483619_ChIP-Seq_HELA_Human1.58738113
50CRX_20693478_ChIP-Seq_RETINA_Mouse1.56614257
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.54203926
52* TBX20_22080862_ChIP-Seq_HEART_Mouse1.53673538
53* TBX20_22328084_ChIP-Seq_HEART_Mouse1.53673538
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53226622
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.53142810
56BCAT_22108803_ChIP-Seq_LS180_Human1.52789150
57CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.51430425
58NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.48713286
59NRF2_20460467_ChIP-Seq_MEFs_Mouse1.48713286
60MYC_19079543_ChIP-ChIP_MESCs_Mouse1.45648278
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.45381934
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.45268030
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.44237063
64CBP_20019798_ChIP-Seq_JUKART_Human1.43558314
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43558314
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43168828
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42577514
68PPAR_26484153_Chip-Seq_NCI-H1993_Human1.41420924
69GBX2_23144817_ChIP-Seq_PC3_Human1.35059036
70NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.34954551
71NFI_21473784_ChIP-Seq_ESCs_Mouse1.33780144
72SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.33346547
73BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.33310107
74TP53_16413492_ChIP-PET_HCT116_Human1.32953857
75YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32860084
76* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.31782316
77NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31743812
78CJUN_26792858_Chip-Seq_BT549_Human1.31554843
79OCT4_21477851_ChIP-Seq_ESCs_Mouse1.30656426
80* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28859321
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.28765189
82TP53_18474530_ChIP-ChIP_U2OS_Human1.27810334
83P53_22387025_ChIP-Seq_ESCs_Mouse1.27353454
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26273989
85* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.24319982
86NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24259087
87GATA2_21666600_ChIP-Seq_HMVEC_Human1.23911277
88TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23652695
89FUS_26573619_Chip-Seq_HEK293_Human1.22843991
90ZFX_18555785_Chip-Seq_ESCs_Mouse1.22677221
91SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.22477414
92ELF1_17652178_ChIP-ChIP_JURKAT_Human1.21815758
93KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.21006150
94KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.21006150
95KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.21006150
96MYC_18358816_ChIP-ChIP_MESCs_Mouse1.20735190
97MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20690742
98* KDM2B_26808549_Chip-Seq_REH_Human1.20557115
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20192613
100CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19937583
101XRN2_22483619_ChIP-Seq_HELA_Human1.19731202
102FOXM1_23109430_ChIP-Seq_U2OS_Human1.17584504
103* SOX2_18555785_Chip-Seq_ESCs_Mouse1.17450218
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15744429
105PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15497935
106GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.15205576
107EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15110176
108NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.15088197
109SMAD4_21799915_ChIP-Seq_A2780_Human1.14303180
110SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.13743438
111KLF4_18555785_Chip-Seq_ESCs_Mouse1.13743239
112GATA1_26923725_Chip-Seq_HPCs_Mouse1.12553302
113POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11898121
114OCT4_18555785_Chip-Seq_ESCs_Mouse1.11716355
115CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11442934
116E2F4_17652178_ChIP-ChIP_JURKAT_Human1.11162157
117E2F1_18555785_Chip-Seq_ESCs_Mouse1.11092403
118LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10146551
119JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10131334
120VDR_23849224_ChIP-Seq_CD4+_Human1.09745191
121SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09102050
122AR_21909140_ChIP-Seq_LNCAP_Human1.08137669
123VDR_22108803_ChIP-Seq_LS180_Human1.07940202
124RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07883787
125EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06417605
126HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.06076577
127* BRD4_25478319_ChIP-Seq_HGPS_Human1.05302255
128* NANOG_16153702_ChIP-ChIP_HESCs_Human1.03528971
129* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.01849319
130RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01475151
131* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.01219101
132DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00064806
133NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99701568
134THAP11_20581084_ChIP-Seq_MESCs_Mouse0.98376555
135P300_18555785_Chip-Seq_ESCs_Mouse0.97901983
136EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.97333258
137ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95351483
138PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94669337
139CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94437504
140KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93811988
141SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.93672118
142SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.93672118
143ESRRB_18555785_Chip-Seq_ESCs_Mouse0.93489416
144NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.93486191
145* PU1_27457419_Chip-Seq_LIVER_Mouse0.92968130
146FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.92269945
147PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.92141942
148SMC1_22415368_ChIP-Seq_MEFs_Mouse0.91855257
149GATA4_21415370_ChIP-Seq_HL-1_Mouse0.91290216
150NMYC_18555785_Chip-Seq_ESCs_Mouse0.91154755
151SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89931104
152E2F1_18555785_ChIP-Seq_MESCs_Mouse0.89512691
153CDX2_22108803_ChIP-Seq_LS180_Human0.89321997
154P300_19829295_ChIP-Seq_ESCs_Human0.88868013
155* STAT3_18555785_Chip-Seq_ESCs_Mouse0.88754058
156CMYC_18555785_Chip-Seq_ESCs_Mouse0.88482092
157HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87473790
158CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.87185496
159TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.86580496
160IGF1R_20145208_ChIP-Seq_DFB_Human0.86501684

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000749_muscle_degeneration6.06995024
2MP0000733_abnormal_muscle_development5.85653235
3MP0000750_abnormal_muscle_regeneration5.74906181
4MP0000751_myopathy5.21445001
5MP0004270_analgesia5.15354025
6MP0004145_abnormal_muscle_electrophysio4.24023345
7MP0000747_muscle_weakness3.82265757
8MP0002106_abnormal_muscle_physiology3.65969843
9MP0001542_abnormal_bone_strength3.49605148
10MP0000759_abnormal_skeletal_muscle3.42348041
11MP0005369_muscle_phenotype3.05389163
12MP0010030_abnormal_orbit_morphology3.00654606
13MP0004087_abnormal_muscle_fiber2.90887508
14MP0003705_abnormal_hypodermis_morpholog2.82814462
15MP0003950_abnormal_plasma_membrane2.71085400
16MP0002269_muscular_atrophy2.53792017
17MP0002108_abnormal_muscle_morphology2.46134270
18MP0002249_abnormal_larynx_morphology2.21634994
19MP0003941_abnormal_skin_development2.18849674
20MP0005360_urolithiasis1.89104587
21MP0002734_abnormal_mechanical_nocicepti1.80586189
22MP0005623_abnormal_meninges_morphology1.77906035
23MP0004233_abnormal_muscle_weight1.67667146
24MP0002837_dystrophic_cardiac_calcinosis1.67442777
25MP0001299_abnormal_eye_distance/1.60757023
26MP0002971_abnormal_brown_adipose1.56439086
27MP0004084_abnormal_cardiac_muscle1.49811798
28MP0001346_abnormal_lacrimal_gland1.48036079
29MP0002163_abnormal_gland_morphology1.46323919
30MP0005620_abnormal_muscle_contractility1.41228957
31MP0005330_cardiomyopathy1.36382952
32MP0004883_abnormal_blood_vessel1.31478463
33MP0002877_abnormal_melanocyte_morpholog1.30782262
34MP0008438_abnormal_cutaneous_collagen1.30566340
35MP0004272_abnormal_basement_membrane1.28991490
36MP0003045_fibrosis1.28325539
37MP0004215_abnormal_myocardial_fiber1.25143545
38MP0003191_abnormal_cellular_cholesterol1.23483025
39MP0006054_spinal_hemorrhage1.23009899
40MP0005503_abnormal_tendon_morphology1.17421004
41MP0008007_abnormal_cellular_replicative1.13868714
42MP0004036_abnormal_muscle_relaxation1.13716502
43MP0009780_abnormal_chondrocyte_physiolo1.11611806
44MP0002234_abnormal_pharynx_morphology1.09507126
45MP0003879_abnormal_hair_cell1.04872488
46MP0003011_delayed_dark_adaptation1.01867160
47MP0003755_abnormal_palate_morphology1.00381785
48MP0005248_abnormal_Harderian_gland0.99019136
49* MP0002114_abnormal_axial_skeleton0.96890104
50MP0009250_abnormal_appendicular_skeleto0.95694851
51MP0001958_emphysema0.94807460
52MP0005367_renal/urinary_system_phenotyp0.94236327
53MP0000516_abnormal_urinary_system0.94236327
54MP0004510_myositis0.92718336
55MP0002277_abnormal_respiratory_mucosa0.92090536
56MP0004484_altered_response_of0.88823100
57MP0010630_abnormal_cardiac_muscle0.87530003
58MP0000372_irregular_coat_pigmentation0.87086001
59MP0005595_abnormal_vascular_smooth0.86796462
60MP0008775_abnormal_heart_ventricle0.86755168
61MP0001661_extended_life_span0.85003990
62MP0002168_other_aberrant_phenotype0.84427896
63MP0002972_abnormal_cardiac_muscle0.84158586
64MP0000858_altered_metastatic_potential0.84057327
65MP0000762_abnormal_tongue_morphology0.82817822
66MP0003111_abnormal_nucleus_morphology0.81888626
67MP0000767_abnormal_smooth_muscle0.81478622
68MP0008932_abnormal_embryonic_tissue0.79921991
69MP0003385_abnormal_body_wall0.79025723
70MP0002933_joint_inflammation0.76707832
71MP0004858_abnormal_nervous_system0.76150588
72MP0005171_absent_coat_pigmentation0.75028792
73MP0002089_abnormal_postnatal_growth/wei0.73744869
74MP0002932_abnormal_joint_morphology0.73351385
75MP0003137_abnormal_impulse_conducting0.72412351
76MP0005385_cardiovascular_system_phenoty0.72264274
77MP0001544_abnormal_cardiovascular_syste0.72264274
78MP0003091_abnormal_cell_migration0.71843339
79MP0005275_abnormal_skin_tensile0.71428842
80MP0005508_abnormal_skeleton_morphology0.70554659
81MP0008877_abnormal_DNA_methylation0.69635863
82MP0003942_abnormal_urinary_system0.66610855
83MP0001943_abnormal_respiration0.66098214
84MP0003828_pulmonary_edema0.65813759
85MP0008789_abnormal_olfactory_epithelium0.65656788
86MP0000538_abnormal_urinary_bladder0.65656404
87MP0002127_abnormal_cardiovascular_syste0.63872302
88MP0003221_abnormal_cardiomyocyte_apopto0.62684859
89MP0003566_abnormal_cell_adhesion0.62104649
90MP0001188_hyperpigmentation0.61334621
91MP0000049_abnormal_middle_ear0.60601056
92MP0005023_abnormal_wound_healing0.60009625
93MP0003077_abnormal_cell_cycle0.59120535
94MP0002896_abnormal_bone_mineralization0.58905212
95MP0005379_endocrine/exocrine_gland_phen0.58558127
96MP0001986_abnormal_taste_sensitivity0.58526049
97MP0002233_abnormal_nose_morphology0.57204560
98MP0003279_aneurysm0.56906482
99MP0001485_abnormal_pinna_reflex0.55121728
100MP0004197_abnormal_fetal_growth/weight/0.55017455
101MP0000428_abnormal_craniofacial_morphol0.52692828
102MP0002822_catalepsy0.52241317
103MP0009384_cardiac_valve_regurgitation0.52238036
104MP0005164_abnormal_response_to0.51841042
105MP0003115_abnormal_respiratory_system0.50288194
106MP0003948_abnormal_gas_homeostasis0.49946341
107MP0008058_abnormal_DNA_repair0.49635908
108MP0010368_abnormal_lymphatic_system0.49413468
109MP0000432_abnormal_head_morphology0.48993227
110MP0000003_abnormal_adipose_tissue0.47317172
111MP0002177_abnormal_outer_ear0.47041662
112MP0005423_abnormal_somatic_nervous0.46303640
113MP0004957_abnormal_blastocyst_morpholog0.46051289
114MP0005165_increased_susceptibility_to0.45741720
115MP0000230_abnormal_systemic_arterial0.45510016
116MP0005266_abnormal_metabolism0.44552619
117MP0005388_respiratory_system_phenotype0.44287999
118MP0002133_abnormal_respiratory_system0.44287999
119MP0003937_abnormal_limbs/digits/tail_de0.43476271
120MP0003315_abnormal_perineum_morphology0.43262381
121* MP0002081_perinatal_lethality0.42846446
122MP0002332_abnormal_exercise_endurance0.41460928
123MP0001440_abnormal_grooming_behavior0.40434362
124MP0002282_abnormal_trachea_morphology0.40302825
125MP0005621_abnormal_cell_physiology0.40283060
126MP0004134_abnormal_chest_morphology0.40162162
127* MP0002184_abnormal_innervation0.40092727
128MP0010094_abnormal_chromosome_stability0.39466687
129MP0009697_abnormal_copulation0.39203660
130MP0001915_intracranial_hemorrhage0.38470431
131MP0003646_muscle_fatigue0.38084650
132MP0002736_abnormal_nociception_after0.37596244
133MP0003693_abnormal_embryo_hatching0.37106109
134MP0002116_abnormal_craniofacial_bone0.36632211
135MP0002128_abnormal_blood_circulation0.35221235
136MP0006138_congestive_heart_failure0.34262163
137MP0002113_abnormal_skeleton_development0.33221582
138MP0001529_abnormal_vocalization0.33221144
139MP0003959_abnormal_lean_body0.32694009
140MP0005390_skeleton_phenotype0.32536290
141MP0002109_abnormal_limb_morphology0.32383503
142MP0005257_abnormal_intraocular_pressure0.32143902
143MP0000013_abnormal_adipose_tissue0.31229013
144MP0003935_abnormal_craniofacial_develop0.31148837

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)8.11574495
2Muscle fiber inclusion bodies (HP:0100299)7.60140411
3Nemaline bodies (HP:0003798)7.38009523
4* Fetal akinesia sequence (HP:0001989)7.21316272
5Distal arthrogryposis (HP:0005684)7.03578636
6* Popliteal pterygium (HP:0009756)6.91958730
7Round ear (HP:0100830)6.46245363
8* Malignant hyperthermia (HP:0002047)6.39595730
9* Amniotic constriction ring (HP:0009775)6.36078840
10* Abnormality of placental membranes (HP:0011409)6.36078840
11Ulnar deviation of the wrist (HP:0003049)6.25550979
12Type 1 muscle fiber predominance (HP:0003803)6.00569663
13* Aplasia of the musculature (HP:0100854)5.88901416
14* Type 2 muscle fiber atrophy (HP:0003554)5.81523817
15Calcaneovalgus deformity (HP:0001848)5.67995114
16* Muscle fiber atrophy (HP:0100295)5.16565569
17Deformed tarsal bones (HP:0008119)5.15440653
18Absent phalangeal crease (HP:0006109)4.86755708
19* Abnormality of the neuromuscular junction (HP:0003398)4.84316555
20* Fatigable weakness (HP:0003473)4.84316555
21* Weak cry (HP:0001612)4.57516980
22Myopathic facies (HP:0002058)4.48320510
23Muscle fiber splitting (HP:0003555)4.32448871
24Difficulty climbing stairs (HP:0003551)4.27937772
25* Akinesia (HP:0002304)4.24497094
26Depressed nasal tip (HP:0000437)4.21901325
27Trismus (HP:0000211)4.18839675
28Abnormal finger flexion creases (HP:0006143)4.06871218
29Difficulty running (HP:0009046)4.06795818
30* Gowers sign (HP:0003391)4.02541129
31Breech presentation (HP:0001623)4.00926088
32Hip contracture (HP:0003273)3.98129793
33Sudden death (HP:0001699)3.94628180
34Decreased muscle mass (HP:0003199)3.88127397
35Abnormality of the calf musculature (HP:0001430)3.81364656
36* Thin ribs (HP:0000883)3.60866292
37Mildly elevated creatine phosphokinase (HP:0008180)3.60006937
38Abnormality of the calcaneus (HP:0008364)3.59209689
39* Pterygium (HP:0001059)3.56066784
40EMG: myopathic abnormalities (HP:0003458)3.54301395
41Calf muscle hypertrophy (HP:0008981)3.53868762
42* Aplasia/Hypoplasia involving the musculature (HP:0001460)3.52513460
43Chin dimple (HP:0010751)3.40798619
44* Bulbar palsy (HP:0001283)3.31871063
45Abnormality of skeletal muscle fiber size (HP:0012084)3.29883754
46Muscle hypertrophy of the lower extremities (HP:0008968)3.22159674
47Distal lower limb amyotrophy (HP:0008944)3.19596563
48Long clavicles (HP:0000890)3.19375957
49* Easy fatigability (HP:0003388)3.12951749
50Exercise-induced muscle cramps (HP:0003710)3.12110876
51* Cystic hygroma (HP:0000476)2.95103868
52* Hypoplastic heart (HP:0001961)2.93736543
53Hyporeflexia of lower limbs (HP:0002600)2.80428745
54Increased connective tissue (HP:0009025)2.75036640
55Limited hip movement (HP:0008800)2.74955280
56Neck muscle weakness (HP:0000467)2.73805225
57Slender build (HP:0001533)2.72774987
58Centrally nucleated skeletal muscle fibers (HP:0003687)2.68445016
59* Abnormalities of placenta or umbilical cord (HP:0001194)2.62646698
60Asymmetric septal hypertrophy (HP:0001670)2.61463535
61Nonprogressive disorder (HP:0003680)2.61362194
62Neonatal respiratory distress (HP:0002643)2.59667524
63Increased variability in muscle fiber diameter (HP:0003557)2.58497149
64Short palpebral fissure (HP:0012745)2.57009470
65Mask-like facies (HP:0000298)2.55111431
66Abnormality of the umbilical cord (HP:0010881)2.46110334
67* Respiratory insufficiency due to muscle weakness (HP:0002747)2.45556275
68Lipoatrophy (HP:0100578)2.45117500
69* Generalized muscle weakness (HP:0003324)2.44847567
70Abnormal auditory evoked potentials (HP:0006958)2.43043933
71Aortic dissection (HP:0002647)2.42198504
72Aortic aneurysm (HP:0004942)2.41984320
73* Webbed neck (HP:0000465)2.40107132
74Lower limb amyotrophy (HP:0007210)2.36189377
75Abnormality of the left ventricular outflow tract (HP:0011103)2.35712067
76Subaortic stenosis (HP:0001682)2.35712067
77Metatarsus adductus (HP:0001840)2.34604486
78Scapular winging (HP:0003691)2.32702700
79Generalized amyotrophy (HP:0003700)2.26519640
80Symphalangism affecting the phalanges of the hand (HP:0009773)2.25268706
81Areflexia of lower limbs (HP:0002522)2.24551232
82Spinal rigidity (HP:0003306)2.22150668
83Delayed gross motor development (HP:0002194)2.20248868
84Shoulder girdle muscle weakness (HP:0003547)2.19651867
85Knee flexion contracture (HP:0006380)2.18324642
86Pelvic girdle muscle weakness (HP:0003749)2.13800968
87* Arthrogryposis multiplex congenita (HP:0002804)2.11880220
88Protrusio acetabuli (HP:0003179)2.09148898
89Abnormality of the musculature of the pelvis (HP:0001469)2.08698240
90Abnormality of the hip-girdle musculature (HP:0001445)2.08698240
91Testicular atrophy (HP:0000029)2.08613028
92* Diminished movement (HP:0002374)2.08373892
93Rocker bottom foot (HP:0001838)2.06103380
94Nasal speech (HP:0001611)2.05530701
95Absent septum pellucidum (HP:0001331)2.03137085
96Exercise-induced myalgia (HP:0003738)2.03074585
97Abnormality of the shoulder girdle musculature (HP:0001435)2.01823753
98Left ventricular hypertrophy (HP:0001712)2.00731122
99Facial diplegia (HP:0001349)1.98775640
100Slender long bone (HP:0003100)1.94447612
101Limb-girdle muscle atrophy (HP:0003797)1.93458421
102Wrist flexion contracture (HP:0001239)1.92667227
103Myotonia (HP:0002486)1.92607242
104Abnormality of the ischium (HP:0003174)1.91769034
105Stillbirth (HP:0003826)1.90317635
106Frequent falls (HP:0002359)1.90253770
107Arterial tortuosity (HP:0005116)1.89095434
108Bell-shaped thorax (HP:0001591)1.88535652
109Fused cervical vertebrae (HP:0002949)1.87403156
110Increased density of long bones (HP:0006392)1.86985707
111Hypoplastic ischia (HP:0003175)1.83381496
112Premature rupture of membranes (HP:0001788)1.79696661
113Abnormality of the septum pellucidum (HP:0007375)1.79509748
114Distal lower limb muscle weakness (HP:0009053)1.78266639
115Spondylolisthesis (HP:0003302)1.78201391
116Reduced subcutaneous adipose tissue (HP:0003758)1.77844309
117Flexion contracture of toe (HP:0005830)1.77081567
118Joint contractures involving the joints of the feet (HP:0100492)1.77081567
119EMG: neuropathic changes (HP:0003445)1.76679454
120Waddling gait (HP:0002515)1.75730010
121Vascular tortuosity (HP:0004948)1.72214432
122Ventricular arrhythmia (HP:0004308)1.72058937
123Abnormal delivery (HP:0001787)1.71109305
124Bundle branch block (HP:0011710)1.70701703
125Tarsal synostosis (HP:0008368)1.70274736
126Hypoplastic nipples (HP:0002557)1.69994778
127Rib fusion (HP:0000902)1.60691289
128Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.60305345
129Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.59240918
130Limb-girdle muscle weakness (HP:0003325)1.58585470
131Synostosis involving bones of the lower limbs (HP:0009138)1.57983579
132Muscle stiffness (HP:0003552)1.48378344
133Mesomelia (HP:0003027)1.44001840
134Dyschromatopsia (HP:0007641)1.42417547

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK9.00211241
2MOS8.06688105
3PIK3CG5.15509683
4PIM23.67394000
5OBSCN2.81181420
6MAP3K122.51956754
7IRAK32.21047466
8MAP2K12.06298689
9TRIB31.88020867
10CDK151.86543254
11PRKD31.85485556
12CDK181.82124810
13CDK141.79185630
14CDK11A1.75548406
15EIF2AK11.70220764
16PAK41.62355341
17MYLK1.59021080
18ZAK1.41935271
19CDK61.37966911
20TTN1.29307678
21BUB11.27499382
22ILK1.25506693
23FRK1.23891228
24VRK21.20343025
25EPHA21.16443358
26PLK41.15463431
27ROCK21.03246812
28AKT21.01687181
29TGFBR21.00756289
30IRAK41.00574241
31NME10.86651702
32NEK10.85638460
33CDK80.83512470
34EIF2AK30.80454297
35MAP3K50.79716293
36TRPM70.79485347
37STK390.78540388
38SRPK10.77106364
39ERBB30.76046594
40LIMK10.75880148
41EIF2AK20.74351234
42MKNK20.67295146
43MAPK120.66695005
44ROCK10.64325416
45FER0.63413856
46PRKD20.61664597
47MAPKAPK30.59779697
48TSSK60.59105044
49BRD40.58466372
50STK160.58430596
51IRAK10.57267801
52DYRK1B0.56326871
53EPHB10.55891911
54MAPK70.55105785
55MAP3K100.54796708
56DAPK10.54727182
57PHKG10.54154666
58PHKG20.54154666
59DDR20.52652266
60PINK10.51706739
61OXSR10.51394180
62ABL20.51136560
63EPHB20.50905395
64BCKDK0.50758094
65BRSK20.50315550
66ABL10.48250283
67WEE10.46929129
68NEK60.46663886
69PAK30.46589234
70MKNK10.45920441
71AURKB0.45470634
72LATS10.43830997
73CAMK2A0.43789253
74PAK20.42448822
75PAK10.42031706
76LATS20.42018598
77RPS6KB20.42010795
78TAF10.41952795
79PBK0.41396625
80PLK20.41204869
81CASK0.41154854
82PAK60.40318854
83INSRR0.39008043
84TTK0.38383187
85MAP3K70.38070254
86CCNB10.37798953
87SIK10.37455197
88IRAK20.37000178
89MAPK130.35485211
90PLK30.35315990
91NME20.34664182
92VRK10.33907801
93CAMK2G0.33859058
94PLK10.33262233
95STK38L0.31218793
96MAP4K20.30976301
97CAMK2D0.30959045
98MTOR0.29712555
99NEK90.29308200
100PRKG10.29074033
101EGFR0.28668752
102PTK20.27411183
103BMPR1B0.26763028
104MAPK110.26353066
105CDK90.25211007
106PRKACB0.25168472
107NUAK10.23825073
108CSNK1G20.23748401
109INSR0.23041461
110FGFR20.22817121
111FLT30.22471449
112MAPK100.22413600
113MARK10.21250959
114CDK10.20928745
115BRSK10.20258345
116MAPKAPK20.19644310
117PDK20.19163283
118MAP3K140.18483281
119GSK3A0.17775515
120PKN20.17679523
121DAPK30.16707904
122PRKCE0.16633770
123IGF1R0.16542472
124TGFBR10.16141726
125NTRK10.15980750
126ALK0.15707828
127RPS6KA30.15456255
128PRKCA0.15363077
129DAPK20.15289514
130MARK20.15065331
131AKT10.13827452
132PIM10.12731155
133PRKCH0.12698555
134IKBKB0.12576230
135CDK20.12377509
136CAMK2B0.12172861
137CHEK10.11544223
138CSNK2A10.11398681
139ADRBK20.10597521
140MINK10.10131104
141MELK0.10063175
142CSNK2A20.09524624
143CDK50.08822419
144PRKCG0.07783301
145DMPK0.07368700
146CSNK1D0.06840366

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.13891475
2Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.87978321
3Proteasome_Homo sapiens_hsa030503.80453821
4Dilated cardiomyopathy_Homo sapiens_hsa054143.73103889
5RNA polymerase_Homo sapiens_hsa030203.02091409
6Cardiac muscle contraction_Homo sapiens_hsa042602.54935440
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.37928174
8Ribosome_Homo sapiens_hsa030102.18106465
9Circadian rhythm_Homo sapiens_hsa047102.04852757
10Tight junction_Homo sapiens_hsa045301.92552299
11Homologous recombination_Homo sapiens_hsa034401.72737831
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.69080268
13Spliceosome_Homo sapiens_hsa030401.64259229
14DNA replication_Homo sapiens_hsa030301.59181578
15p53 signaling pathway_Homo sapiens_hsa041151.59119495
16RNA transport_Homo sapiens_hsa030131.58074449
17Cell cycle_Homo sapiens_hsa041101.57549787
18Pyrimidine metabolism_Homo sapiens_hsa002401.54554844
19Nucleotide excision repair_Homo sapiens_hsa034201.51755808
20Fanconi anemia pathway_Homo sapiens_hsa034601.51065318
21Viral myocarditis_Homo sapiens_hsa054161.50220497
22Epstein-Barr virus infection_Homo sapiens_hsa051691.37856389
23Focal adhesion_Homo sapiens_hsa045101.37799082
24Parkinsons disease_Homo sapiens_hsa050121.36330504
25RNA degradation_Homo sapiens_hsa030181.36222824
26Sulfur metabolism_Homo sapiens_hsa009201.35729789
27Oxidative phosphorylation_Homo sapiens_hsa001901.35103972
28Basal transcription factors_Homo sapiens_hsa030221.32913012
29Mismatch repair_Homo sapiens_hsa034301.31902673
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31266873
31Protein export_Homo sapiens_hsa030601.30368505
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.27806883
33ECM-receptor interaction_Homo sapiens_hsa045121.25723588
34Selenocompound metabolism_Homo sapiens_hsa004501.23613643
35Proteoglycans in cancer_Homo sapiens_hsa052051.21200927
36One carbon pool by folate_Homo sapiens_hsa006701.18943075
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.18715738
38Propanoate metabolism_Homo sapiens_hsa006401.18596128
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18015323
40Glucagon signaling pathway_Homo sapiens_hsa049221.16804508
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.12431377
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.11917019
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09210924
44Arginine and proline metabolism_Homo sapiens_hsa003301.07260795
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06235789
46Huntingtons disease_Homo sapiens_hsa050161.04922378
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.03791349
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02969311
49Melanoma_Homo sapiens_hsa052181.02502426
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98329397
51Purine metabolism_Homo sapiens_hsa002300.96792242
52Salmonella infection_Homo sapiens_hsa051320.95554570
53Pyruvate metabolism_Homo sapiens_hsa006200.92955630
54Alzheimers disease_Homo sapiens_hsa050100.92461054
55Non-homologous end-joining_Homo sapiens_hsa034500.91260551
56Oxytocin signaling pathway_Homo sapiens_hsa049210.90650993
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89393765
58Regulation of actin cytoskeleton_Homo sapiens_hsa048100.89170302
59Base excision repair_Homo sapiens_hsa034100.89105862
60Starch and sucrose metabolism_Homo sapiens_hsa005000.88940833
61Fatty acid elongation_Homo sapiens_hsa000620.87693517
62Adherens junction_Homo sapiens_hsa045200.87478648
63Gap junction_Homo sapiens_hsa045400.85735827
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81968237
65Bladder cancer_Homo sapiens_hsa052190.81016178
66Butanoate metabolism_Homo sapiens_hsa006500.75215501
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.72748466
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72056284
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71499758
70MAPK signaling pathway_Homo sapiens_hsa040100.71370376
71Folate biosynthesis_Homo sapiens_hsa007900.69128227
72Hedgehog signaling pathway_Homo sapiens_hsa043400.68295860
73Mineral absorption_Homo sapiens_hsa049780.68264542
74Arachidonic acid metabolism_Homo sapiens_hsa005900.68066182
75HTLV-I infection_Homo sapiens_hsa051660.68004806
76Hippo signaling pathway_Homo sapiens_hsa043900.67647821
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67172612
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65751840
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.64924249
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64742716
81Prostate cancer_Homo sapiens_hsa052150.63949900
82FoxO signaling pathway_Homo sapiens_hsa040680.63696220
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63374597
84Basal cell carcinoma_Homo sapiens_hsa052170.63137288
85* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62523704
86Salivary secretion_Homo sapiens_hsa049700.61461821
87Axon guidance_Homo sapiens_hsa043600.61355969
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60653148
89Chronic myeloid leukemia_Homo sapiens_hsa052200.60507160
90HIF-1 signaling pathway_Homo sapiens_hsa040660.59906301
91Phagosome_Homo sapiens_hsa041450.58993424
92MicroRNAs in cancer_Homo sapiens_hsa052060.58639052
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56969962
94Amoebiasis_Homo sapiens_hsa051460.56503442
95TGF-beta signaling pathway_Homo sapiens_hsa043500.55669576
96Protein digestion and absorption_Homo sapiens_hsa049740.55422068
97Apoptosis_Homo sapiens_hsa042100.54384852
98Malaria_Homo sapiens_hsa051440.52294481
99Biosynthesis of amino acids_Homo sapiens_hsa012300.51314477
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.51033284
101Rheumatoid arthritis_Homo sapiens_hsa053230.50195215
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48939076
103mRNA surveillance pathway_Homo sapiens_hsa030150.48838342
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47481217
105Viral carcinogenesis_Homo sapiens_hsa052030.47229105
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46819445
107Wnt signaling pathway_Homo sapiens_hsa043100.46537290
108Graft-versus-host disease_Homo sapiens_hsa053320.46311975
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45672713
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44247848
111Carbon metabolism_Homo sapiens_hsa012000.43102969
112AMPK signaling pathway_Homo sapiens_hsa041520.42809596
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42159663
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41234245
115Legionellosis_Homo sapiens_hsa051340.41009770
116Endocytosis_Homo sapiens_hsa041440.40695585
117Shigellosis_Homo sapiens_hsa051310.40617388
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39115935
119Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39005705
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37989971
121Insulin resistance_Homo sapiens_hsa049310.37541607
122Allograft rejection_Homo sapiens_hsa053300.36934384
123Pathways in cancer_Homo sapiens_hsa052000.36769970
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35743386
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.35325610
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.35066433
127Sulfur relay system_Homo sapiens_hsa041220.35063785
128Renin secretion_Homo sapiens_hsa049240.34182837
129Notch signaling pathway_Homo sapiens_hsa043300.33896174
130Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33863656
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33425329
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33394963
133Small cell lung cancer_Homo sapiens_hsa052220.33332239
134Lysine degradation_Homo sapiens_hsa003100.33315234
135Glutathione metabolism_Homo sapiens_hsa004800.32908402
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30083554
137Hepatitis B_Homo sapiens_hsa051610.29588334
138Vibrio cholerae infection_Homo sapiens_hsa051100.29541426
139Melanogenesis_Homo sapiens_hsa049160.29461827
140Sphingolipid metabolism_Homo sapiens_hsa006000.29457707
141Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28285781
142Fatty acid degradation_Homo sapiens_hsa000710.28022795
143Insulin signaling pathway_Homo sapiens_hsa049100.27433879
144AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.27173834
145Calcium signaling pathway_Homo sapiens_hsa040200.26033052
146Serotonergic synapse_Homo sapiens_hsa047260.23672149
147Intestinal immune network for IgA production_Homo sapiens_hsa046720.22729919
148SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22563833
149Glioma_Homo sapiens_hsa052140.20470766

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