

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of relaxation of muscle (GO:1901077) | 8.13891243 |
| 2 | actin filament-based movement (GO:0030048) | 7.46494385 |
| 3 | striated muscle contraction (GO:0006941) | 7.24247515 |
| 4 | vitamin transmembrane transport (GO:0035461) | 7.00615208 |
| 5 | skeletal muscle fiber development (GO:0048741) | 6.94383795 |
| 6 | response to muscle activity (GO:0014850) | 6.64274713 |
| 7 | myotube cell development (GO:0014904) | 6.09024883 |
| 8 | lung-associated mesenchyme development (GO:0060484) | 5.91983827 |
| 9 | mitotic metaphase plate congression (GO:0007080) | 5.88798255 |
| 10 | glycogen catabolic process (GO:0005980) | 5.76698372 |
| 11 | response to inactivity (GO:0014854) | 5.72949397 |
| 12 | glucan catabolic process (GO:0009251) | 5.49135042 |
| 13 | muscle contraction (GO:0006936) | 5.45925998 |
| 14 | ventricular cardiac muscle cell development (GO:0055015) | 5.41647430 |
| 15 | neurotransmitter catabolic process (GO:0042135) | 5.33809497 |
| 16 | regulation of spindle organization (GO:0090224) | 5.24272738 |
| 17 | cellular polysaccharide catabolic process (GO:0044247) | 5.17486300 |
| 18 | rRNA modification (GO:0000154) | 5.14119425 |
| 19 | glycogen biosynthetic process (GO:0005978) | 5.00008159 |
| 20 | glucan biosynthetic process (GO:0009250) | 5.00008159 |
| 21 | muscle system process (GO:0003012) | 4.93004661 |
| 22 | purine nucleobase biosynthetic process (GO:0009113) | 4.90467133 |
| 23 | muscle fiber development (GO:0048747) | 4.90423360 |
| 24 | cardiac muscle contraction (GO:0060048) | 4.88326178 |
| 25 | skeletal muscle tissue regeneration (GO:0043403) | 4.74532692 |
| 26 | cardiac muscle cell development (GO:0055013) | 4.71835955 |
| 27 | regulation of actin filament-based movement (GO:1903115) | 4.66555403 |
| 28 | polysaccharide catabolic process (GO:0000272) | 4.65221530 |
| 29 | striated muscle adaptation (GO:0014888) | 4.55495001 |
| 30 | skeletal muscle tissue development (GO:0007519) | 4.53137980 |
| 31 | sarcomere organization (GO:0045214) | 4.52367577 |
| 32 | rRNA methylation (GO:0031167) | 4.51852599 |
| 33 | regulation of mitotic spindle organization (GO:0060236) | 4.51667359 |
| 34 | cardiac cell development (GO:0055006) | 4.50478713 |
| 35 | ribosome assembly (GO:0042255) | 4.43046889 |
| 36 | metaphase plate congression (GO:0051310) | 4.41980597 |
| 37 | termination of RNA polymerase III transcription (GO:0006386) | 4.38297510 |
| 38 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.38297510 |
| 39 | myofibril assembly (GO:0030239) | 4.29324152 |
| 40 | muscle organ morphogenesis (GO:0048644) | 4.29262655 |
| 41 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 4.26187542 |
| 42 | myoblast fusion (GO:0007520) | 4.26101465 |
| 43 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 4.25412417 |
| 44 | muscle filament sliding (GO:0030049) | 4.24687784 |
| 45 | actin-myosin filament sliding (GO:0033275) | 4.24687784 |
| 46 | cardiac muscle hypertrophy (GO:0003300) | 4.23315548 |
| 47 | positive regulation of myotube differentiation (GO:0010831) | 4.21812074 |
| 48 | NADH metabolic process (GO:0006734) | 4.21596343 |
| 49 | response to activity (GO:0014823) | 4.15126706 |
| 50 | muscle cell cellular homeostasis (GO:0046716) | 4.15082412 |
| 51 | ventricular cardiac muscle cell action potential (GO:0086005) | 4.12161439 |
| 52 | regulation of skeletal muscle contraction (GO:0014819) | 4.11454179 |
| 53 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 4.10996940 |
| 54 | biotin metabolic process (GO:0006768) | 4.09887973 |
| 55 | regulation of cell communication by electrical coupling (GO:0010649) | 4.06452087 |
| 56 | positive regulation of chromosome segregation (GO:0051984) | 4.06392433 |
| 57 | glycogen metabolic process (GO:0005977) | 4.06082296 |
| 58 | 2-oxoglutarate metabolic process (GO:0006103) | 4.05846184 |
| 59 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 4.04951421 |
| 60 | nucleobase biosynthetic process (GO:0046112) | 4.03979960 |
| 61 | striated muscle hypertrophy (GO:0014897) | 4.02493492 |
| 62 | glucan metabolic process (GO:0044042) | 4.00197510 |
| 63 | cellular glucan metabolic process (GO:0006073) | 4.00197510 |
| 64 | fructose metabolic process (GO:0006000) | 3.99855179 |
| 65 | ribosome biogenesis (GO:0042254) | 3.98911886 |
| 66 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 3.98760582 |
| 67 | syncytium formation by plasma membrane fusion (GO:0000768) | 3.97059015 |
| 68 | DNA replication checkpoint (GO:0000076) | 3.96272062 |
| 69 | termination of RNA polymerase I transcription (GO:0006363) | 3.96264018 |
| 70 | muscle adaptation (GO:0043500) | 3.91763732 |
| 71 | regulation of G0 to G1 transition (GO:0070316) | 3.86626093 |
| 72 | intestinal epithelial cell development (GO:0060576) | 3.86347737 |
| 73 | cardiac myofibril assembly (GO:0055003) | 3.80275139 |
| 74 | transcription from RNA polymerase I promoter (GO:0006360) | 3.75536317 |
| 75 | IMP metabolic process (GO:0046040) | 3.74978081 |
| 76 | muscle structure development (GO:0061061) | 3.72597861 |
| 77 | monoubiquitinated protein deubiquitination (GO:0035520) | 3.69601067 |
| 78 | muscle organ development (GO:0007517) | 3.66079363 |
| 79 | striated muscle cell development (GO:0055002) | 3.63455883 |
| 80 | skeletal muscle adaptation (GO:0043501) | 3.63058996 |
| 81 | muscle hypertrophy (GO:0014896) | 3.62412019 |
| 82 | regulation of exit from mitosis (GO:0007096) | 3.62075707 |
| 83 | muscle atrophy (GO:0014889) | 3.61898181 |
| 84 | folic acid transport (GO:0015884) | 3.60770251 |
| 85 | blastocyst development (GO:0001824) | 3.59639878 |
| 86 | negative regulation of muscle contraction (GO:0045932) | 3.58479042 |
| 87 | positive regulation of cardiac muscle cell proliferation (GO:0060045) | 3.58335485 |
| 88 | adult heart development (GO:0007512) | 3.57526653 |
| 89 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 3.55349464 |
| 90 | neuronal action potential propagation (GO:0019227) | 3.55174173 |
| 91 | positive regulation of mitochondrial calcium ion concentration (GO:0051561) | 3.54121404 |
| 92 | regulation of striated muscle contraction (GO:0006942) | 3.53488753 |
| 93 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 3.49859140 |
| 94 | folic acid metabolic process (GO:0046655) | 3.49242996 |
| 95 | serine family amino acid catabolic process (GO:0009071) | 3.48622044 |
| 96 | pyrimidine-containing compound transmembrane transport (GO:0072531) | 3.48035037 |
| 97 | gluconeogenesis (GO:0006094) | 3.45457674 |
| 98 | positive regulation of calcium ion transmembrane transporter activity (GO:1901021) | 3.45076970 |
| 99 | negative regulation of fibroblast apoptotic process (GO:2000270) | 3.44757012 |
| 100 | actin-mediated cell contraction (GO:0070252) | 3.43125061 |
| 101 | positive regulation of cardiac muscle tissue growth (GO:0055023) | 3.43066315 |
| 102 | positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261) | 3.41538121 |
| 103 | 7-methylguanosine mRNA capping (GO:0006370) | 3.40824296 |
| 104 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 3.40243254 |
| 105 | positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110 | 3.39470363 |
| 106 | mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686) | 3.39470363 |
| 107 | muscle tissue morphogenesis (GO:0060415) | 3.35884480 |
| 108 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 3.34118144 |
| 109 | cardiac muscle adaptation (GO:0014887) | 3.31532948 |
| 110 | cardiac muscle hypertrophy in response to stress (GO:0014898) | 3.31532948 |
| 111 | muscle hypertrophy in response to stress (GO:0003299) | 3.31532948 |
| 112 | cellular carbohydrate catabolic process (GO:0044275) | 3.30765211 |
| 113 | regulation of skeletal muscle cell differentiation (GO:2001014) | 3.30038950 |
| 114 | protein localization to kinetochore (GO:0034501) | 3.27097612 |
| 115 | positive regulation of protein depolymerization (GO:1901881) | 3.25731167 |
| 116 | ubiquinone biosynthetic process (GO:0006744) | 3.25310371 |
| 117 | 7-methylguanosine RNA capping (GO:0009452) | 3.24562873 |
| 118 | RNA capping (GO:0036260) | 3.24562873 |
| 119 | plasma membrane repair (GO:0001778) | 3.23712714 |
| 120 | germinal center formation (GO:0002467) | 3.21456831 |
| 121 | neuromuscular synaptic transmission (GO:0007274) | 3.21081419 |
| 122 | negative regulation of necroptotic process (GO:0060546) | 3.18230304 |
| 123 | regulation of calcium ion transmembrane transporter activity (GO:1901019) | 3.18123065 |
| 124 | regulation of calcium ion transmembrane transport (GO:1903169) | 3.18123065 |
| 125 | syncytium formation (GO:0006949) | 3.17520086 |
| 126 | establishment of chromosome localization (GO:0051303) | 3.15026170 |
| 127 | hexose biosynthetic process (GO:0019319) | 3.14188097 |
| 128 | protein localization to chromosome, centromeric region (GO:0071459) | 3.14142857 |
| 129 | heart process (GO:0003015) | 3.13974065 |
| 130 | heart contraction (GO:0060047) | 3.13974065 |
| 131 | otic vesicle formation (GO:0030916) | 3.13680537 |
| 132 | cardiac muscle tissue morphogenesis (GO:0055008) | 3.13050508 |
| 133 | muscle cell development (GO:0055001) | 3.11017227 |
| 134 | labyrinthine layer development (GO:0060711) | 3.10446686 |
| 135 | positive regulation of DNA-templated transcription, initiation (GO:2000144) | 3.09822782 |
| 136 | actomyosin structure organization (GO:0031032) | 3.09693290 |
| 137 | muscle cell fate commitment (GO:0042693) | 3.09003407 |
| 138 | carnitine shuttle (GO:0006853) | 3.08900329 |
| 139 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.08563340 |
| 140 | regulation of sequestering of triglyceride (GO:0010889) | 3.06195705 |
| 141 | regulation of cardioblast differentiation (GO:0051890) | 3.05847664 |
| 142 | regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) | 3.05567529 |
| 143 | meiosis I (GO:0007127) | 3.04459254 |
| 144 | cardiac muscle cell action potential involved in contraction (GO:0086002) | 3.02394509 |
| 145 | skeletal muscle cell differentiation (GO:0035914) | 3.00573805 |
| 146 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 3.00172802 |
| 147 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 2.99758956 |
| 148 | purine nucleotide salvage (GO:0032261) | 2.98762069 |
| 149 | relaxation of muscle (GO:0090075) | 2.98148460 |
| 150 | striated muscle atrophy (GO:0014891) | 2.97703961 |
| 151 | cardiac muscle cell action potential (GO:0086001) | 2.97476220 |
| 152 | striated muscle tissue development (GO:0014706) | 2.97091853 |
| 153 | CDP-diacylglycerol metabolic process (GO:0046341) | 2.96649967 |
| 154 | spindle checkpoint (GO:0031577) | 2.93655606 |
| 155 | tricarboxylic acid cycle (GO:0006099) | 2.93371640 |
| 156 | glycine metabolic process (GO:0006544) | 2.93004502 |
| 157 | positive regulation of mitochondrial membrane permeability (GO:0035794) | 2.92341216 |
| 158 | synaptonemal complex assembly (GO:0007130) | 2.89923736 |
| 159 | DNA-templated transcription, elongation (GO:0006354) | 2.89332812 |
| 160 | skeletal muscle contraction (GO:0003009) | 2.88177901 |
| 161 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 2.80930013 |
| 162 | positive regulation of heart growth (GO:0060421) | 2.80809050 |
| 163 | GMP metabolic process (GO:0046037) | 2.80586081 |
| 164 | transcription elongation from RNA polymerase II promoter (GO:0006368) | 2.80434612 |
| 165 | fatty acid homeostasis (GO:0055089) | 2.79894193 |
| 166 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 2.78812995 |
| 167 | regulation of chromosome segregation (GO:0051983) | 2.77222126 |
| 168 | synaptonemal complex organization (GO:0070193) | 2.76597236 |
| 169 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.75412637 |
| 170 | proteasome assembly (GO:0043248) | 2.73830486 |
| 171 | response to stimulus involved in regulation of muscle adaptation (GO:0014874) | 2.73734096 |
| 172 | attachment of spindle microtubules to kinetochore (GO:0008608) | 2.72717036 |
| 173 | protein K6-linked ubiquitination (GO:0085020) | 2.71756751 |
| 174 | creatine metabolic process (GO:0006600) | 2.68164383 |
| 175 | S-adenosylmethionine metabolic process (GO:0046500) | 2.68055693 |
| 176 | polyamine biosynthetic process (GO:0006596) | 2.67869190 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 8.28967359 |
| 2 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.48877439 |
| 3 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 6.40211107 |
| 4 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 4.66792592 |
| 5 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 4.25963610 |
| 6 | ZNF263_19887448_ChIP-Seq_K562_Human | 3.84515765 |
| 7 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.65192055 |
| 8 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.40412297 |
| 9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.05153608 |
| 10 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 3.04145733 |
| 11 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.02470966 |
| 12 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.88096576 |
| 13 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.83314897 |
| 14 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.71571301 |
| 15 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 2.49483202 |
| 16 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.42690328 |
| 17 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.39051727 |
| 18 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.36344771 |
| 19 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.32709052 |
| 20 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 2.32224339 |
| 21 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 2.18418169 |
| 22 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.16055802 |
| 23 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 2.15797567 |
| 24 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.04056509 |
| 25 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.96453800 |
| 26 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.92937426 |
| 27 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.91018475 |
| 28 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.90511495 |
| 29 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.83407786 |
| 30 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.83390008 |
| 31 | * CTCF_27219007_Chip-Seq_Bcells_Human | 1.77646097 |
| 32 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.76606366 |
| 33 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.74480793 |
| 34 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.71074326 |
| 35 | CTCF_21964334_ChIP-Seq_BJAB-B_Human | 1.70804720 |
| 36 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.70104706 |
| 37 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.67537099 |
| 38 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.64601515 |
| 39 | P68_20966046_ChIP-Seq_HELA_Human | 1.61306582 |
| 40 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.56755828 |
| 41 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.56395878 |
| 42 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.55569068 |
| 43 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.55303161 |
| 44 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.53689888 |
| 45 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.53671769 |
| 46 | MAF_26560356_Chip-Seq_TH1_Human | 1.51743685 |
| 47 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.51696417 |
| 48 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 1.50886803 |
| 49 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.49721067 |
| 50 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.49045544 |
| 51 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 1.48398967 |
| 52 | MAF_26560356_Chip-Seq_TH2_Human | 1.48197028 |
| 53 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.47371819 |
| 54 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.46155075 |
| 55 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 1.45413192 |
| 56 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 1.45127964 |
| 57 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.41341310 |
| 58 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 1.40106321 |
| 59 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.39257116 |
| 60 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.38886117 |
| 61 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.37745635 |
| 62 | SPI1_20517297_ChIP-Seq_HL60_Human | 1.37451472 |
| 63 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.37364344 |
| 64 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.36960518 |
| 65 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.36108811 |
| 66 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.35960852 |
| 67 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.34317147 |
| 68 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.33918816 |
| 69 | * SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.33319043 |
| 70 | * SPI1_23127762_ChIP-Seq_K562_Human | 1.30520914 |
| 71 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.28660382 |
| 72 | MYC_22102868_ChIP-Seq_BL_Human | 1.28452552 |
| 73 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.28138770 |
| 74 | OCT4_20526341_ChIP-Seq_ESCs_Human | 1.27511173 |
| 75 | NANOG_18692474_ChIP-Seq_MEFs_Mouse | 1.27251416 |
| 76 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.26945249 |
| 77 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.25876195 |
| 78 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.24471998 |
| 79 | CTCF_21964334_Chip-Seq_Bcells_Human | 1.24436298 |
| 80 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.23273825 |
| 81 | E2F1_20622854_ChIP-Seq_HELA_Human | 1.22586830 |
| 82 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.21962825 |
| 83 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.21758275 |
| 84 | MYC_27129775_Chip-Seq_CORNEA_Mouse | 1.21330033 |
| 85 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.21186060 |
| 86 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.21079222 |
| 87 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.20430322 |
| 88 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 1.19941906 |
| 89 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 1.19495149 |
| 90 | STAT1_20625510_ChIP-Seq_HELA_Human | 1.19364681 |
| 91 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.19346402 |
| 92 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 1.18104796 |
| 93 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.17897643 |
| 94 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 1.17801069 |
| 95 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.17609981 |
| 96 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.17191747 |
| 97 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.16214825 |
| 98 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.15451020 |
| 99 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.14688983 |
| 100 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.14674549 |
| 101 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.14348722 |
| 102 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.12558884 |
| 103 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.11684921 |
| 104 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.10755345 |
| 105 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 1.09845277 |
| 106 | SMC3_22415368_ChIP-Seq_MEFs_Mouse | 1.09490919 |
| 107 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.09428085 |
| 108 | TP63_22573176_ChIP-Seq_HFKS_Human | 1.08144076 |
| 109 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.08005419 |
| 110 | STAT3_19079543_ChIP-ChIP_MESCs_Mouse | 1.07345767 |
| 111 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.07188799 |
| 112 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.06595115 |
| 113 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.06206758 |
| 114 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.06189586 |
| 115 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.05841122 |
| 116 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 1.05372279 |
| 117 | NANOG_18347094_ChIP-ChIP_MESCs_Mouse | 1.04301742 |
| 118 | NANOG_18692474_ChIP-Seq_MESCs_Mouse | 1.03804500 |
| 119 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.03510314 |
| 120 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 1.03422499 |
| 121 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.03322530 |
| 122 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.02568021 |
| 123 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.02403701 |
| 124 | OCT4_19829295_ChIP-Seq_ESCs_Human | 1.02234347 |
| 125 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.01817911 |
| 126 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.00867769 |
| 127 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.00190176 |
| 128 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.99561923 |
| 129 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 0.99094816 |
| 130 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 0.98788499 |
| 131 | PHF8_20622854_ChIP-Seq_HELA_Human | 0.98334760 |
| 132 | RAC3_21632823_ChIP-Seq_H3396_Human | 0.98124850 |
| 133 | GATA4_21415370_ChIP-Seq_HL-1_Mouse | 0.97828585 |
| 134 | CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 0.97552958 |
| 135 | CEBPB_22108803_ChIP-Seq_LS180_Human | 0.97314288 |
| 136 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 0.96041629 |
| 137 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.95982450 |
| 138 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 0.95060691 |
| 139 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.94752997 |
| 140 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.94481567 |
| 141 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.93503571 |
| 142 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 0.93480740 |
| 143 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.93076913 |
| 144 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 0.92567430 |
| 145 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 0.92567430 |
| 146 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.92270811 |
| 147 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.91802625 |
| 148 | DCP1A_22483619_ChIP-Seq_HELA_Human | 0.90469447 |
| 149 | SA1_27219007_Chip-Seq_Bcells_Human | 0.90112483 |
| 150 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.89859383 |
| 151 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.89406827 |
| 152 | KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse | 0.89328997 |
| 153 | ATF3_27146783_Chip-Seq_COLON_Human | 0.89325731 |
| 154 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.88649864 |
| 155 | * GATA3_21867929_ChIP-Seq_CD8_Mouse | 0.88350002 |
| 156 | SMC1_22415368_ChIP-Seq_MEFs_Mouse | 0.88232971 |
| 157 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.87705265 |
| 158 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.87613805 |
| 159 | UTX_26944678_Chip-Seq_JUKART_Human | 0.87381316 |
| 160 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.87115247 |
| 161 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.86893446 |
| 162 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 0.86720719 |
| 163 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.86580502 |
| 164 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.85880364 |
| 165 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.85857303 |
| 166 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.85415713 |
| 167 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.84937995 |
| 168 | TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse | 0.84217926 |
| 169 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.83767223 |
| 170 | POU5F1_18692474_ChIP-Seq_MESCs_Mouse | 0.83080851 |
| 171 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.82975833 |
| 172 | VDR_24787735_ChIP-Seq_THP-1_Human | 0.82740275 |
| 173 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 0.80392925 |
| 174 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 0.80343431 |
| 175 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 0.80343431 |
| 176 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 0.80343431 |
| 177 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.80175342 |
| 178 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.78236359 |
| 179 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.77327223 |
| 180 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.76368152 |
| 181 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 0.75426713 |
| 182 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 0.75300166 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | * MP0003879_abnormal_hair_cell | 4.21206883 |
| 2 | MP0002254_reproductive_system_inflammat | 4.08089821 |
| 3 | MP0003646_muscle_fatigue | 3.91837023 |
| 4 | MP0005377_hearing/vestibular/ear_phenot | 3.75616509 |
| 5 | MP0003878_abnormal_ear_physiology | 3.75616509 |
| 6 | MP0001485_abnormal_pinna_reflex | 3.58198244 |
| 7 | MP0004084_abnormal_cardiac_muscle | 3.30173967 |
| 8 | MP0003693_abnormal_embryo_hatching | 3.18732197 |
| 9 | MP0004145_abnormal_muscle_electrophysio | 3.15238089 |
| 10 | MP0000751_myopathy | 2.93865122 |
| 11 | MP0002837_dystrophic_cardiac_calcinosis | 2.89149047 |
| 12 | MP0004036_abnormal_muscle_relaxation | 2.79652888 |
| 13 | MP0000750_abnormal_muscle_regeneration | 2.59820577 |
| 14 | MP0004215_abnormal_myocardial_fiber | 2.53389653 |
| 15 | MP0000749_muscle_degeneration | 2.52339716 |
| 16 | MP0001346_abnormal_lacrimal_gland | 2.47704775 |
| 17 | MP0000566_synostosis | 2.41583096 |
| 18 | MP0002106_abnormal_muscle_physiology | 2.33299159 |
| 19 | MP0005330_cardiomyopathy | 2.26593606 |
| 20 | MP0003941_abnormal_skin_development | 2.17309964 |
| 21 | MP0002269_muscular_atrophy | 2.17220838 |
| 22 | MP0003718_maternal_effect | 2.13837230 |
| 23 | MP0001348_abnormal_lacrimal_gland | 2.09030881 |
| 24 | MP0003221_abnormal_cardiomyocyte_apopto | 2.08891087 |
| 25 | MP0000747_muscle_weakness | 2.08134406 |
| 26 | MP0008260_abnormal_autophagy | 2.06647112 |
| 27 | MP0003111_abnormal_nucleus_morphology | 2.03365537 |
| 28 | MP0002876_abnormal_thyroid_physiology | 1.88857109 |
| 29 | MP0004087_abnormal_muscle_fiber | 1.86788709 |
| 30 | MP0004510_myositis | 1.82797283 |
| 31 | MP0003567_abnormal_fetal_cardiomyocyte | 1.82464913 |
| 32 | MP0003828_pulmonary_edema | 1.82445864 |
| 33 | MP0005369_muscle_phenotype | 1.78090832 |
| 34 | MP0005620_abnormal_muscle_contractility | 1.73266821 |
| 35 | MP0006138_congestive_heart_failure | 1.69774426 |
| 36 | MP0002108_abnormal_muscle_morphology | 1.67674903 |
| 37 | MP0005310_abnormal_salivary_gland | 1.58952714 |
| 38 | MP0003137_abnormal_impulse_conducting | 1.58308206 |
| 39 | MP0005266_abnormal_metabolism | 1.55711897 |
| 40 | MP0004484_altered_response_of | 1.54925981 |
| 41 | MP0000759_abnormal_skeletal_muscle | 1.52986836 |
| 42 | MP0004957_abnormal_blastocyst_morpholog | 1.47574042 |
| 43 | MP0001661_extended_life_span | 1.46639516 |
| 44 | MP0008057_abnormal_DNA_replication | 1.46584122 |
| 45 | MP0005385_cardiovascular_system_phenoty | 1.46497619 |
| 46 | MP0001544_abnormal_cardiovascular_syste | 1.46497619 |
| 47 | MP0002972_abnormal_cardiac_muscle | 1.45845376 |
| 48 | * MP0000026_abnormal_inner_ear | 1.43439627 |
| 49 | MP0005645_abnormal_hypothalamus_physiol | 1.41564788 |
| 50 | * MP0001963_abnormal_hearing_physiology | 1.37690841 |
| 51 | MP0000013_abnormal_adipose_tissue | 1.37247594 |
| 52 | MP0002971_abnormal_brown_adipose | 1.36212395 |
| 53 | MP0000383_abnormal_hair_follicle | 1.33020933 |
| 54 | MP0003077_abnormal_cell_cycle | 1.32666350 |
| 55 | MP0006036_abnormal_mitochondrial_physio | 1.27958457 |
| 56 | MP0003950_abnormal_plasma_membrane | 1.21034371 |
| 57 | MP0003938_abnormal_ear_development | 1.19972947 |
| 58 | MP0010630_abnormal_cardiac_muscle | 1.19607582 |
| 59 | MP0005375_adipose_tissue_phenotype | 1.18888063 |
| 60 | MP0004130_abnormal_muscle_cell | 1.17756185 |
| 61 | MP0005670_abnormal_white_adipose | 1.16439824 |
| 62 | MP0008058_abnormal_DNA_repair | 1.04468760 |
| 63 | MP0000733_abnormal_muscle_development | 1.01866891 |
| 64 | MP0010678_abnormal_skin_adnexa | 1.00204781 |
| 65 | MP0001730_embryonic_growth_arrest | 0.99517369 |
| 66 | MP0002653_abnormal_ependyma_morphology | 0.97171172 |
| 67 | MP0003656_abnormal_erythrocyte_physiolo | 0.94285254 |
| 68 | MP0002127_abnormal_cardiovascular_syste | 0.93101675 |
| 69 | MP0004147_increased_porphyrin_level | 0.89063150 |
| 70 | MP0005380_embryogenesis_phenotype | 0.89041117 |
| 71 | MP0001672_abnormal_embryogenesis/_devel | 0.89041117 |
| 72 | MP0000579_abnormal_nail_morphology | 0.86822740 |
| 73 | MP0004270_analgesia | 0.85777503 |
| 74 | MP0008775_abnormal_heart_ventricle | 0.85530163 |
| 75 | MP0008932_abnormal_embryonic_tissue | 0.85426103 |
| 76 | MP0003786_premature_aging | 0.84717769 |
| 77 | MP0001299_abnormal_eye_distance/ | 0.82901416 |
| 78 | MP0003303_peritoneal_inflammation | 0.82511397 |
| 79 | MP0010030_abnormal_orbit_morphology | 0.80431395 |
| 80 | MP0004185_abnormal_adipocyte_glucose | 0.77022104 |
| 81 | MP0000428_abnormal_craniofacial_morphol | 0.76327444 |
| 82 | MP0001849_ear_inflammation | 0.75985335 |
| 83 | MP0000613_abnormal_salivary_gland | 0.74702206 |
| 84 | MP0004885_abnormal_endolymph | 0.73870290 |
| 85 | MP0004085_abnormal_heartbeat | 0.72941904 |
| 86 | MP0005395_other_phenotype | 0.72643193 |
| 87 | MP0005451_abnormal_body_composition | 0.70554936 |
| 88 | MP0002088_abnormal_embryonic_growth/wei | 0.69392333 |
| 89 | MP0005166_decreased_susceptibility_to | 0.69142890 |
| 90 | MP0008007_abnormal_cellular_replicative | 0.68893386 |
| 91 | MP0003984_embryonic_growth_retardation | 0.68436698 |
| 92 | MP0001986_abnormal_taste_sensitivity | 0.66640670 |
| 93 | MP0009840_abnormal_foam_cell | 0.66080851 |
| 94 | MP0000003_abnormal_adipose_tissue | 0.65857115 |
| 95 | MP0010094_abnormal_chromosome_stability | 0.64667340 |
| 96 | MP0004043_abnormal_pH_regulation | 0.63858030 |
| 97 | MP0008789_abnormal_olfactory_epithelium | 0.63136124 |
| 98 | MP0008877_abnormal_DNA_methylation | 0.63013207 |
| 99 | MP0005083_abnormal_biliary_tract | 0.62970839 |
| 100 | MP0005167_abnormal_blood-brain_barrier | 0.62900353 |
| 101 | MP0005647_abnormal_sex_gland | 0.62718346 |
| 102 | MP0000350_abnormal_cell_proliferation | 0.61320122 |
| 103 | MP0002332_abnormal_exercise_endurance | 0.60787957 |
| 104 | MP0004233_abnormal_muscle_weight | 0.57741567 |
| 105 | MP0001697_abnormal_embryo_size | 0.57354960 |
| 106 | MP0003045_fibrosis | 0.55577955 |
| 107 | MP0002210_abnormal_sex_determination | 0.55321493 |
| 108 | MP0002080_prenatal_lethality | 0.54769256 |
| 109 | MP0005535_abnormal_body_temperature | 0.54447874 |
| 110 | MP0002877_abnormal_melanocyte_morpholog | 0.53881926 |
| 111 | MP0004858_abnormal_nervous_system | 0.53830859 |
| 112 | MP0003123_paternal_imprinting | 0.53512130 |
| 113 | MP0002234_abnormal_pharynx_morphology | 0.53458057 |
| 114 | MP0009672_abnormal_birth_weight | 0.52902553 |
| 115 | MP0000372_irregular_coat_pigmentation | 0.52740046 |
| 116 | MP0002085_abnormal_embryonic_tissue | 0.52068518 |
| 117 | MP0009278_abnormal_bone_marrow | 0.50291543 |
| 118 | MP0006035_abnormal_mitochondrial_morpho | 0.49570978 |
| 119 | MP0005666_abnormal_adipose_tissue | 0.49115506 |
| 120 | MP0003755_abnormal_palate_morphology | 0.48769801 |
| 121 | MP0005187_abnormal_penis_morphology | 0.47801033 |
| 122 | MP0003806_abnormal_nucleotide_metabolis | 0.46982763 |
| 123 | MP0010307_abnormal_tumor_latency | 0.46940733 |
| 124 | MP0002163_abnormal_gland_morphology | 0.46359754 |
| 125 | MP0000266_abnormal_heart_morphology | 0.46235033 |
| 126 | MP0001873_stomach_inflammation | 0.45720432 |
| 127 | MP0005376_homeostasis/metabolism_phenot | 0.45668215 |
| 128 | MP0002078_abnormal_glucose_homeostasis | 0.43888628 |
| 129 | MP0005410_abnormal_fertilization | 0.40667656 |
| 130 | MP0004381_abnormal_hair_follicle | 0.39129456 |
| 131 | MP0005319_abnormal_enzyme/_coenzyme | 0.38661390 |
| 132 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.38361251 |
| 133 | MP0005423_abnormal_somatic_nervous | 0.38157020 |
| 134 | MP0000343_altered_response_to | 0.36772606 |
| 135 | MP0008569_lethality_at_weaning | 0.32514864 |
| 136 | MP0003948_abnormal_gas_homeostasis | 0.31318373 |
| 137 | MP0009764_decreased_sensitivity_to | 0.29988268 |
| 138 | MP0005334_abnormal_fat_pad | 0.29474645 |
| 139 | MP0002277_abnormal_respiratory_mucosa | 0.27529382 |
| 140 | MP0002128_abnormal_blood_circulation | 0.27457094 |
| 141 | MP0005452_abnormal_adipose_tissue | 0.26806463 |
| 142 | MP0004142_abnormal_muscle_tone | 0.23304143 |
| 143 | MP0008874_decreased_physiological_sensi | 0.22347914 |
| 144 | MP0003705_abnormal_hypodermis_morpholog | 0.21823936 |
| 145 | MP0005058_abnormal_lysosome_morphology | 0.21364994 |
| 146 | MP0002132_abnormal_respiratory_system | 0.21101774 |
| 147 | MP0005248_abnormal_Harderian_gland | 0.19723911 |
| 148 | MP0003075_altered_response_to | 0.18869033 |
| 149 | MP0009115_abnormal_fat_cell | 0.18799983 |
| 150 | MP0002138_abnormal_hepatobiliary_system | 0.17998459 |
| 151 | MP0003724_increased_susceptibility_to | 0.17799139 |
| 152 | MP0005387_immune_system_phenotype | 0.17718244 |
| 153 | MP0001790_abnormal_immune_system | 0.17718244 |
| 154 | MP0002114_abnormal_axial_skeleton | 0.17240248 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Muscle fiber splitting (HP:0003555) | 6.22168822 |
| 2 | Hyperglycinemia (HP:0002154) | 5.12969321 |
| 3 | Round ear (HP:0100830) | 4.75533404 |
| 4 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 4.73911315 |
| 5 | Ulnar deviation of the wrist (HP:0003049) | 4.72795745 |
| 6 | Bundle branch block (HP:0011710) | 4.70226350 |
| 7 | Muscle hypertrophy of the lower extremities (HP:0008968) | 4.67915471 |
| 8 | Abnormality of skeletal muscle fiber size (HP:0012084) | 4.28800478 |
| 9 | Sudden death (HP:0001699) | 4.25145626 |
| 10 | Atrioventricular block (HP:0001678) | 4.21616520 |
| 11 | Calf muscle hypertrophy (HP:0008981) | 4.21468894 |
| 12 | Areflexia of lower limbs (HP:0002522) | 4.17415633 |
| 13 | Hyperglycinuria (HP:0003108) | 4.16471103 |
| 14 | Exercise-induced muscle cramps (HP:0003710) | 4.07544442 |
| 15 | Ventricular tachycardia (HP:0004756) | 4.05244968 |
| 16 | Asymmetric septal hypertrophy (HP:0001670) | 3.99062883 |
| 17 | Exercise-induced myalgia (HP:0003738) | 3.95958215 |
| 18 | Ventricular fibrillation (HP:0001663) | 3.95864997 |
| 19 | Muscle fiber inclusion bodies (HP:0100299) | 3.93048636 |
| 20 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 3.86069354 |
| 21 | Frequent falls (HP:0002359) | 3.71367502 |
| 22 | Muscle stiffness (HP:0003552) | 3.67573427 |
| 23 | Heart block (HP:0012722) | 3.64645215 |
| 24 | Distal lower limb muscle weakness (HP:0009053) | 3.55936127 |
| 25 | Nemaline bodies (HP:0003798) | 3.50956617 |
| 26 | Progressive muscle weakness (HP:0003323) | 3.50126741 |
| 27 | Absent phalangeal crease (HP:0006109) | 3.49123957 |
| 28 | Difficulty climbing stairs (HP:0003551) | 3.46935558 |
| 29 | Hyperglycemia (HP:0003074) | 3.43798077 |
| 30 | Abnormality of glycine metabolism (HP:0010895) | 3.41218009 |
| 31 | Abnormality of serine family amino acid metabolism (HP:0010894) | 3.41218009 |
| 32 | Abnormal atrioventricular conduction (HP:0005150) | 3.37942512 |
| 33 | Gout (HP:0001997) | 3.36670057 |
| 34 | Increased variability in muscle fiber diameter (HP:0003557) | 3.35710328 |
| 35 | Malignant hyperthermia (HP:0002047) | 3.24762246 |
| 36 | Difficulty running (HP:0009046) | 3.14636341 |
| 37 | Ventricular arrhythmia (HP:0004308) | 3.08308761 |
| 38 | Right ventricular cardiomyopathy (HP:0011663) | 3.06461276 |
| 39 | Hyporeflexia of lower limbs (HP:0002600) | 3.05184809 |
| 40 | Generalized muscle weakness (HP:0003324) | 3.04036713 |
| 41 | Syncope (HP:0001279) | 3.01395603 |
| 42 | Impulsivity (HP:0100710) | 3.01335702 |
| 43 | EMG: neuropathic changes (HP:0003445) | 2.99761843 |
| 44 | Increased connective tissue (HP:0009025) | 2.98688507 |
| 45 | Abnormality of the calf musculature (HP:0001430) | 2.96613262 |
| 46 | Type 2 muscle fiber atrophy (HP:0003554) | 2.92565737 |
| 47 | Congenital, generalized hypertrichosis (HP:0004540) | 2.92422748 |
| 48 | Double outlet right ventricle (HP:0001719) | 2.84407386 |
| 49 | Congenital malformation of the right heart (HP:0011723) | 2.84407386 |
| 50 | Abnormal finger flexion creases (HP:0006143) | 2.80616609 |
| 51 | Hypoplastic ischia (HP:0003175) | 2.80605776 |
| 52 | Distal lower limb amyotrophy (HP:0008944) | 2.79113055 |
| 53 | Rimmed vacuoles (HP:0003805) | 2.77634185 |
| 54 | Weak cry (HP:0001612) | 2.73295739 |
| 55 | Muscle fibrillation (HP:0010546) | 2.72898704 |
| 56 | Irregular epiphyses (HP:0010582) | 2.70169515 |
| 57 | Mildly elevated creatine phosphokinase (HP:0008180) | 2.69763749 |
| 58 | Hyperkalemia (HP:0002153) | 2.69210763 |
| 59 | Breast hypoplasia (HP:0003187) | 2.67612939 |
| 60 | Abnormal auditory evoked potentials (HP:0006958) | 2.67304694 |
| 61 | Muscle fiber atrophy (HP:0100295) | 2.66698997 |
| 62 | Myopathic facies (HP:0002058) | 2.65907862 |
| 63 | Subaortic stenosis (HP:0001682) | 2.65580058 |
| 64 | Abnormality of the left ventricular outflow tract (HP:0011103) | 2.65580058 |
| 65 | Bulbar palsy (HP:0001283) | 2.63203932 |
| 66 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 2.62582260 |
| 67 | EMG: myopathic abnormalities (HP:0003458) | 2.62341905 |
| 68 | Slender build (HP:0001533) | 2.62031671 |
| 69 | Cerebral hypomyelination (HP:0006808) | 2.59289538 |
| 70 | Birth length less than 3rd percentile (HP:0003561) | 2.56804143 |
| 71 | Abnormality of the ischium (HP:0003174) | 2.52273123 |
| 72 | Myotonia (HP:0002486) | 2.51283013 |
| 73 | Atrial fibrillation (HP:0005110) | 2.48140101 |
| 74 | Abnormality of the neuromuscular junction (HP:0003398) | 2.47616203 |
| 75 | Fatigable weakness (HP:0003473) | 2.47616203 |
| 76 | Hyperuricemia (HP:0002149) | 2.45277010 |
| 77 | Increased purine levels (HP:0004368) | 2.45277010 |
| 78 | Distal arthrogryposis (HP:0005684) | 2.42418503 |
| 79 | Neck muscle weakness (HP:0000467) | 2.42327100 |
| 80 | Multiple enchondromatosis (HP:0005701) | 2.42039789 |
| 81 | Reduced subcutaneous adipose tissue (HP:0003758) | 2.40935307 |
| 82 | Calcaneovalgus deformity (HP:0001848) | 2.39539206 |
| 83 | Carpal bone hypoplasia (HP:0001498) | 2.39298926 |
| 84 | Deformed tarsal bones (HP:0008119) | 2.38654340 |
| 85 | Type 1 muscle fiber predominance (HP:0003803) | 2.36448285 |
| 86 | Myoglobinuria (HP:0002913) | 2.32732624 |
| 87 | Gowers sign (HP:0003391) | 2.32527392 |
| 88 | Rhabdomyolysis (HP:0003201) | 2.31714351 |
| 89 | Insulin-resistant diabetes mellitus (HP:0000831) | 2.31537591 |
| 90 | Limb-girdle muscle atrophy (HP:0003797) | 2.28798265 |
| 91 | Entropion (HP:0000621) | 2.27916799 |
| 92 | Shoulder girdle muscle weakness (HP:0003547) | 2.27547300 |
| 93 | Primary atrial arrhythmia (HP:0001692) | 2.27507243 |
| 94 | Abnormality of the calcaneus (HP:0008364) | 2.26951037 |
| 95 | Lipoatrophy (HP:0100578) | 2.24317861 |
| 96 | Unilateral renal agenesis (HP:0000122) | 2.23793753 |
| 97 | Ragged-red muscle fibers (HP:0003200) | 2.23095714 |
| 98 | Scapular winging (HP:0003691) | 2.21627248 |
| 99 | Pelvic girdle muscle weakness (HP:0003749) | 2.20160543 |
| 100 | Tongue fasciculations (HP:0001308) | 2.19621308 |
| 101 | Waddling gait (HP:0002515) | 2.19291175 |
| 102 | Supraventricular tachycardia (HP:0004755) | 2.19187683 |
| 103 | Lip pit (HP:0100267) | 2.17423152 |
| 104 | Pustule (HP:0200039) | 2.15581520 |
| 105 | Supraventricular arrhythmia (HP:0005115) | 2.13122814 |
| 106 | Fetal akinesia sequence (HP:0001989) | 2.12353530 |
| 107 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 2.10462076 |
| 108 | Abnormality of serum amino acid levels (HP:0003112) | 2.10113848 |
| 109 | Mutism (HP:0002300) | 2.07837770 |
| 110 | Proximal amyotrophy (HP:0007126) | 2.07552606 |
| 111 | Rough bone trabeculation (HP:0100670) | 2.06810695 |
| 112 | Abnormality of the umbilical cord (HP:0010881) | 2.02667177 |
| 113 | Abnormality of the hip-girdle musculature (HP:0001445) | 2.02547492 |
| 114 | Abnormality of the musculature of the pelvis (HP:0001469) | 2.02547492 |
| 115 | Premature rupture of membranes (HP:0001788) | 2.01511968 |
| 116 | Spinal rigidity (HP:0003306) | 2.01318734 |
| 117 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 2.01031684 |
| 118 | Absent epiphyses (HP:0010577) | 2.01031684 |
| 119 | Alopecia of scalp (HP:0002293) | 2.00972654 |
| 120 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.99336828 |
| 121 | Hip contracture (HP:0003273) | 1.97170655 |
| 122 | Synostosis involving the elbow (HP:0003938) | 1.97147574 |
| 123 | Humeroradial synostosis (HP:0003041) | 1.97147574 |
| 124 | Testicular atrophy (HP:0000029) | 1.96735718 |
| 125 | Muscular dystrophy (HP:0003560) | 1.95164063 |
| 126 | Lower limb amyotrophy (HP:0007210) | 1.95121342 |
| 127 | Patellar aplasia (HP:0006443) | 1.94780490 |
| 128 | Paralysis (HP:0003470) | 1.92376106 |
| 129 | Facial diplegia (HP:0001349) | 1.92354662 |
| 130 | Death in infancy (HP:0001522) | 1.92235652 |
| 131 | Type I diabetes mellitus (HP:0100651) | 1.91607446 |
| 132 | Dilated cardiomyopathy (HP:0001644) | 1.91353493 |
| 133 | Keratoconjunctivitis (HP:0001096) | 1.90763070 |
| 134 | Abnormality of the foot musculature (HP:0001436) | 1.85786484 |
| 135 | Abnormality of the shoulder girdle musculature (HP:0001435) | 1.75233318 |
| 136 | Metatarsus adductus (HP:0001840) | 1.69808864 |
| 137 | Foot dorsiflexor weakness (HP:0009027) | 1.69356125 |
| 138 | Respiratory insufficiency due to muscle weakness (HP:0002747) | 1.68602501 |
| 139 | Exercise intolerance (HP:0003546) | 1.66509176 |
| 140 | Nonprogressive disorder (HP:0003680) | 1.60669605 |
| 141 | Long clavicles (HP:0000890) | 1.58355533 |
| 142 | Popliteal pterygium (HP:0009756) | 1.55666708 |
| 143 | Limb-girdle muscle weakness (HP:0003325) | 1.55144090 |
| 144 | Ulnar deviation of finger (HP:0009465) | 1.42873352 |
| 145 | Easy fatigability (HP:0003388) | 1.37272033 |
| 146 | Fatigue (HP:0012378) | 1.28959808 |
| 147 | Amniotic constriction ring (HP:0009775) | 1.21387084 |
| 148 | Abnormality of placental membranes (HP:0011409) | 1.21387084 |
| 149 | Ulnar deviation of the hand or of fingers of the hand (HP:0001193) | 1.20981806 |
| 150 | Increased intramyocellular lipid droplets (HP:0012240) | 1.20923330 |
| 151 | Truncal obesity (HP:0001956) | 1.18758788 |
| 152 | Progressive external ophthalmoplegia (HP:0000590) | 1.17615762 |
| 153 | Limited hip movement (HP:0008800) | 1.17548390 |
| 154 | Short palpebral fissure (HP:0012745) | 1.16195017 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 5.21473047 |
| 2 | OBSCN | 3.46119847 |
| 3 | NME1 | 3.35152388 |
| 4 | EPHA3 | 3.11787291 |
| 5 | PIK3CG | 3.04035166 |
| 6 | WEE1 | 2.97919785 |
| 7 | TTN | 2.78078211 |
| 8 | PINK1 | 2.74907901 |
| 9 | PHKG1 | 2.69968998 |
| 10 | PHKG2 | 2.69968998 |
| 11 | MAP2K3 | 2.69617978 |
| 12 | ZAK | 2.64810440 |
| 13 | NEK1 | 2.48974157 |
| 14 | DYRK3 | 2.39871619 |
| 15 | DDR2 | 2.39392077 |
| 16 | AKT3 | 2.35527606 |
| 17 | LATS1 | 2.07281334 |
| 18 | NEK2 | 2.06412598 |
| 19 | MAPK12 | 2.04471549 |
| 20 | EIF2AK1 | 1.93889871 |
| 21 | LMTK2 | 1.84669928 |
| 22 | LATS2 | 1.82786832 |
| 23 | EPHA2 | 1.81333284 |
| 24 | IRAK3 | 1.70919717 |
| 25 | MKNK2 | 1.67915560 |
| 26 | BRSK2 | 1.61254375 |
| 27 | TTK | 1.60442818 |
| 28 | STK38L | 1.58429988 |
| 29 | PLK3 | 1.52041248 |
| 30 | PDK4 | 1.52030974 |
| 31 | PDK3 | 1.52030974 |
| 32 | DYRK1B | 1.51265336 |
| 33 | STK24 | 1.50738521 |
| 34 | PLK1 | 1.50726814 |
| 35 | SRPK1 | 1.42067236 |
| 36 | PLK4 | 1.40155566 |
| 37 | MKNK1 | 1.37859663 |
| 38 | NME2 | 1.29181701 |
| 39 | STK3 | 1.19360089 |
| 40 | MAP2K4 | 1.19269193 |
| 41 | DMPK | 1.14545046 |
| 42 | BRSK1 | 1.14116109 |
| 43 | MAP2K6 | 1.05077629 |
| 44 | ARAF | 1.04395818 |
| 45 | PRKAA1 | 1.03650914 |
| 46 | EIF2AK3 | 1.01880801 |
| 47 | CDK3 | 0.99140223 |
| 48 | WNK1 | 0.98235413 |
| 49 | PAK3 | 0.97357317 |
| 50 | KSR2 | 0.97315489 |
| 51 | CCNB1 | 0.96577006 |
| 52 | NUAK1 | 0.96376849 |
| 53 | AURKB | 0.93057220 |
| 54 | GRK7 | 0.92724900 |
| 55 | PDK2 | 0.90224071 |
| 56 | MAP3K13 | 0.90068221 |
| 57 | TRPM7 | 0.90023342 |
| 58 | TBK1 | 0.88666629 |
| 59 | BCKDK | 0.87234771 |
| 60 | ICK | 0.85761843 |
| 61 | MAP3K3 | 0.84465548 |
| 62 | KSR1 | 0.80451079 |
| 63 | EIF2AK2 | 0.80183078 |
| 64 | MARK3 | 0.78291845 |
| 65 | MAPKAPK3 | 0.77007860 |
| 66 | MAP3K1 | 0.76725958 |
| 67 | MOS | 0.75446219 |
| 68 | CAMK4 | 0.74928287 |
| 69 | MAP3K14 | 0.74149047 |
| 70 | PRKCI | 0.73236322 |
| 71 | EEF2K | 0.73063404 |
| 72 | ACVR1B | 0.72651456 |
| 73 | SIK1 | 0.71379998 |
| 74 | BRAF | 0.69644648 |
| 75 | CHEK2 | 0.69299924 |
| 76 | TSSK6 | 0.67994044 |
| 77 | ALK | 0.67491874 |
| 78 | MELK | 0.66781904 |
| 79 | TAOK2 | 0.65253400 |
| 80 | PAK6 | 0.62460738 |
| 81 | MAP3K11 | 0.61550584 |
| 82 | EPHB2 | 0.59465712 |
| 83 | MAPK7 | 0.59277437 |
| 84 | PRKAA2 | 0.58897836 |
| 85 | MAPK11 | 0.58447632 |
| 86 | FGFR4 | 0.57449575 |
| 87 | AURKA | 0.56662499 |
| 88 | CAMK2G | 0.54689640 |
| 89 | MARK2 | 0.54391002 |
| 90 | MUSK | 0.54167655 |
| 91 | MARK1 | 0.53702080 |
| 92 | MAP2K1 | 0.52640897 |
| 93 | RPS6KA4 | 0.51603890 |
| 94 | TAOK1 | 0.51014978 |
| 95 | CSNK1E | 0.50659927 |
| 96 | CDK19 | 0.47467892 |
| 97 | PIK3CA | 0.47407089 |
| 98 | MAPK13 | 0.46556460 |
| 99 | TRIB3 | 0.46299542 |
| 100 | CHEK1 | 0.44171594 |
| 101 | CDK8 | 0.43527938 |
| 102 | STK16 | 0.43217929 |
| 103 | SGK3 | 0.43087088 |
| 104 | CAMK1 | 0.43001273 |
| 105 | PRKG1 | 0.42874131 |
| 106 | PDGFRA | 0.42664270 |
| 107 | MAPK4 | 0.42450898 |
| 108 | TIE1 | 0.42412604 |
| 109 | EPHB1 | 0.41871033 |
| 110 | INSRR | 0.41865430 |
| 111 | PRPF4B | 0.41792984 |
| 112 | TNK2 | 0.40635492 |
| 113 | PKN1 | 0.40376831 |
| 114 | DYRK2 | 0.40277845 |
| 115 | BLK | 0.38669592 |
| 116 | ERBB3 | 0.37715633 |
| 117 | PDK1 | 0.34565483 |
| 118 | STK38 | 0.34033882 |
| 119 | ZAP70 | 0.32406492 |
| 120 | PRKD2 | 0.31383163 |
| 121 | RAF1 | 0.31277509 |
| 122 | CAMK2D | 0.30951120 |
| 123 | MAP3K8 | 0.30432270 |
| 124 | RPS6KC1 | 0.30121253 |
| 125 | RPS6KL1 | 0.30121253 |
| 126 | PRKACB | 0.29332386 |
| 127 | STK11 | 0.29244024 |
| 128 | CSK | 0.28737844 |
| 129 | AKT2 | 0.28581215 |
| 130 | ROCK1 | 0.28478131 |
| 131 | SGK1 | 0.28123140 |
| 132 | MAP3K7 | 0.26868433 |
| 133 | CDK7 | 0.26627006 |
| 134 | RPS6KA1 | 0.26623451 |
| 135 | MTOR | 0.26357985 |
| 136 | NEK6 | 0.26112052 |
| 137 | CAMK2A | 0.24389480 |
| 138 | RPS6KA6 | 0.23765145 |
| 139 | PDPK1 | 0.22682943 |
| 140 | RPS6KA5 | 0.22648490 |
| 141 | PRKACA | 0.22300370 |
| 142 | RIPK1 | 0.22080016 |
| 143 | MAPK10 | 0.22038946 |
| 144 | STK39 | 0.21973576 |
| 145 | MAP2K2 | 0.21920570 |
| 146 | FGFR3 | 0.21899161 |
| 147 | CDK2 | 0.21744567 |
| 148 | CSNK1A1L | 0.21729014 |
| 149 | CDK1 | 0.20322521 |
| 150 | PRKCG | 0.20031805 |
| 151 | SGK2 | 0.19923836 |
| 152 | MAP3K5 | 0.19848647 |
| 153 | JAK2 | 0.19836003 |
| 154 | RPS6KA3 | 0.19703256 |
| 155 | GRK5 | 0.19644444 |
| 156 | IKBKE | 0.19608560 |
| 157 | CSNK1G3 | 0.19551714 |
| 158 | LIMK1 | 0.19532586 |
| 159 | SIK2 | 0.18864281 |
| 160 | CDC42BPA | 0.18649247 |
| 161 | NEK9 | 0.18610101 |
| 162 | CHUK | 0.15639039 |
| 163 | RPS6KB1 | 0.13614736 |
| 164 | CDK9 | 0.13076091 |
| 165 | TYK2 | 0.12335895 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 8.03498622 |
| 2 | RNA polymerase_Homo sapiens_hsa03020 | 4.89779530 |
| 3 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.71959664 |
| 4 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 2.69056859 |
| 5 | Proteasome_Homo sapiens_hsa03050 | 2.46657713 |
| 6 | RNA transport_Homo sapiens_hsa03013 | 2.41944572 |
| 7 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 2.14055873 |
| 8 | Regulation of autophagy_Homo sapiens_hsa04140 | 2.07748668 |
| 9 | Cell cycle_Homo sapiens_hsa04110 | 2.07109560 |
| 10 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 2.05394467 |
| 11 | Basal transcription factors_Homo sapiens_hsa03022 | 1.98438032 |
| 12 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.96914971 |
| 13 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.90166602 |
| 14 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.84997155 |
| 15 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.83893768 |
| 16 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 1.72495139 |
| 17 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.70127109 |
| 18 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.60723643 |
| 19 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.46213178 |
| 20 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.43379076 |
| 21 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.42420988 |
| 22 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.41315456 |
| 23 | Purine metabolism_Homo sapiens_hsa00230 | 1.38673435 |
| 24 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.38625501 |
| 25 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.31740437 |
| 26 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.31070942 |
| 27 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.27806220 |
| 28 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.20849953 |
| 29 | Circadian rhythm_Homo sapiens_hsa04710 | 1.19170078 |
| 30 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.15400994 |
| 31 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.15106922 |
| 32 | Spliceosome_Homo sapiens_hsa03040 | 1.14694195 |
| 33 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.12802358 |
| 34 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.08697569 |
| 35 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.05511298 |
| 36 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.99545856 |
| 37 | Carbon metabolism_Homo sapiens_hsa01200 | 0.97888445 |
| 38 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.96365782 |
| 39 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.96119669 |
| 40 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.95790374 |
| 41 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.93249580 |
| 42 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.91645358 |
| 43 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.91608799 |
| 44 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.90571044 |
| 45 | Long-term potentiation_Homo sapiens_hsa04720 | 0.90023789 |
| 46 | Galactose metabolism_Homo sapiens_hsa00052 | 0.89347712 |
| 47 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.88265170 |
| 48 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.87084686 |
| 49 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.85758419 |
| 50 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.85349449 |
| 51 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.85206173 |
| 52 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.84517779 |
| 53 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.84445624 |
| 54 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.83097587 |
| 55 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.81915359 |
| 56 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.81114246 |
| 57 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.80983588 |
| 58 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.80087561 |
| 59 | Huntingtons disease_Homo sapiens_hsa05016 | 0.80029586 |
| 60 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.80019444 |
| 61 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.79111546 |
| 62 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.77824395 |
| 63 | Sulfur relay system_Homo sapiens_hsa04122 | 0.76626285 |
| 64 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.74869377 |
| 65 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.72386434 |
| 66 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.72168685 |
| 67 | Tight junction_Homo sapiens_hsa04530 | 0.71157014 |
| 68 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.69829252 |
| 69 | Tuberculosis_Homo sapiens_hsa05152 | 0.67538874 |
| 70 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.67003797 |
| 71 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.65678433 |
| 72 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.64621203 |
| 73 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.64547462 |
| 74 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.63476081 |
| 75 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.63337472 |
| 76 | Legionellosis_Homo sapiens_hsa05134 | 0.63224116 |
| 77 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.62047510 |
| 78 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.61633706 |
| 79 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.59410102 |
| 80 | Homologous recombination_Homo sapiens_hsa03440 | 0.56813364 |
| 81 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.56016688 |
| 82 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.54783831 |
| 83 | Insulin resistance_Homo sapiens_hsa04931 | 0.54654419 |
| 84 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.54046536 |
| 85 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.53792092 |
| 86 | Parkinsons disease_Homo sapiens_hsa05012 | 0.53758597 |
| 87 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.53355609 |
| 88 | Melanoma_Homo sapiens_hsa05218 | 0.53326892 |
| 89 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.53276382 |
| 90 | Thyroid cancer_Homo sapiens_hsa05216 | 0.51089439 |
| 91 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.50594201 |
| 92 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.50259807 |
| 93 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.46709739 |
| 94 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.45874210 |
| 95 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.45709857 |
| 96 | Glioma_Homo sapiens_hsa05214 | 0.45019107 |
| 97 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.44280695 |
| 98 | Bladder cancer_Homo sapiens_hsa05219 | 0.43644110 |
| 99 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.42776247 |
| 100 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.42278158 |
| 101 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.41285286 |
| 102 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.40999182 |
| 103 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.40943275 |
| 104 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.39556216 |
| 105 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.39452712 |
| 106 | Viral myocarditis_Homo sapiens_hsa05416 | 0.37492100 |
| 107 | Metabolic pathways_Homo sapiens_hsa01100 | 0.37142373 |
| 108 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.36699950 |
| 109 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.36245217 |
| 110 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.36003860 |
| 111 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.35488640 |
| 112 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.35377174 |
| 113 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.34975908 |
| 114 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.34330978 |
| 115 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.33039867 |
| 116 | Ribosome_Homo sapiens_hsa03010 | 0.31837124 |
| 117 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.31648494 |
| 118 | Long-term depression_Homo sapiens_hsa04730 | 0.31294053 |
| 119 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.30898593 |
| 120 | Platelet activation_Homo sapiens_hsa04611 | 0.29749663 |
| 121 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.29588174 |
| 122 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.28608712 |
| 123 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.28134533 |
| 124 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.27709650 |
| 125 | Malaria_Homo sapiens_hsa05144 | 0.26922145 |
| 126 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.26773516 |
| 127 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.26669371 |
| 128 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.25953989 |
| 129 | Influenza A_Homo sapiens_hsa05164 | 0.25825161 |
| 130 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.25192656 |
| 131 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.25088818 |
| 132 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.24927037 |
| 133 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.24760438 |
| 134 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.24447339 |
| 135 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.24411191 |
| 136 | Alzheimers disease_Homo sapiens_hsa05010 | 0.24193835 |
| 137 | Renin secretion_Homo sapiens_hsa04924 | 0.23973591 |
| 138 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.23762572 |
| 139 | RNA degradation_Homo sapiens_hsa03018 | 0.22992598 |
| 140 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.22869884 |
| 141 | Leishmaniasis_Homo sapiens_hsa05140 | 0.22656795 |
| 142 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.22023637 |
| 143 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.21587308 |
| 144 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.20898232 |
| 145 | HTLV-I infection_Homo sapiens_hsa05166 | 0.20727240 |
| 146 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.19686608 |
| 147 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.19088619 |
| 148 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.18700229 |
| 149 | Histidine metabolism_Homo sapiens_hsa00340 | 0.14350457 |

