CHRNA6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronal nicotinic acetylcholine receptors that mediate dopaminergic neurotransmission and are activated by acetylcholine and exogenous nicotine. Alternatively spliced transcript variants have been observed for this gene. Single nucleotide polymorphisms in this gene have been associated with both nicotine and alcohol dependence. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)8.89422459
2dopamine biosynthetic process (GO:0042416)8.81781653
3dopamine transport (GO:0015872)8.68046484
4regulation of catecholamine metabolic process (GO:0042069)8.27892910
5regulation of dopamine metabolic process (GO:0042053)8.27892910
6tachykinin receptor signaling pathway (GO:0007217)7.30787020
7positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)7.06362956
8growth hormone secretion (GO:0030252)6.96437195
9alkaloid metabolic process (GO:0009820)6.83865429
10mating behavior (GO:0007617)6.66846434
11positive regulation of growth hormone secretion (GO:0060124)6.57739794
12catecholamine transport (GO:0051937)6.36460962
13regulation of inhibitory postsynaptic membrane potential (GO:0060080)6.34113420
14positive regulation of uterine smooth muscle contraction (GO:0070474)6.09486954
15sequestering of actin monomers (GO:0042989)6.06694386
16behavioral response to nicotine (GO:0035095)5.86977392
17hyperosmotic salinity response (GO:0042538)5.58103325
18synaptic vesicle exocytosis (GO:0016079)5.34745051
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.28009271
20catechol-containing compound biosynthetic process (GO:0009713)5.17486265
21catecholamine biosynthetic process (GO:0042423)5.17486265
22response to cocaine (GO:0042220)5.15423854
23regulation of uterine smooth muscle contraction (GO:0070472)4.95639339
24neuron cell-cell adhesion (GO:0007158)4.89368202
25response to insecticide (GO:0017085)4.87374402
26negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.86497580
27synaptic transmission, dopaminergic (GO:0001963)4.80904159
28glutamate secretion (GO:0014047)4.79404767
29phosphatidylinositol acyl-chain remodeling (GO:0036149)4.78508205
30phosphatidylserine acyl-chain remodeling (GO:0036150)4.78187558
31regulation of growth hormone secretion (GO:0060123)4.69698373
32negative regulation of leukocyte chemotaxis (GO:0002689)4.69540583
33neurotransmitter biosynthetic process (GO:0042136)4.64904641
34phenol-containing compound catabolic process (GO:0019336)4.58400455
35positive regulation of synaptic transmission, GABAergic (GO:0032230)4.58214427
36prepulse inhibition (GO:0060134)4.55107131
37synaptic transmission, cholinergic (GO:0007271)4.54869901
38cellular response to nicotine (GO:0071316)4.54333939
39regulation of short-term neuronal synaptic plasticity (GO:0048172)4.50977358
40detection of light stimulus involved in sensory perception (GO:0050962)4.42635254
41detection of light stimulus involved in visual perception (GO:0050908)4.42635254
42mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.40822111
43regulation of chemokine-mediated signaling pathway (GO:0070099)4.39271576
44regulation of feeding behavior (GO:0060259)4.38114217
45microtubule depolymerization (GO:0007019)4.30870247
46regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)4.28006916
47neuron projection extension involved in neuron projection guidance (GO:1902284)4.25092842
48axon extension involved in axon guidance (GO:0048846)4.25092842
49phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.23807344
50dopamine metabolic process (GO:0042417)4.23035502
51membrane hyperpolarization (GO:0060081)4.13562740
52positive regulation of sodium ion transmembrane transporter activity (GO:2000651)4.08841974
53determination of adult lifespan (GO:0008340)4.08190118
54chaperone-mediated protein complex assembly (GO:0051131)4.05522770
55protein complex biogenesis (GO:0070271)4.04054373
56neuron-neuron synaptic transmission (GO:0007270)3.96775459
57synaptic vesicle maturation (GO:0016188)3.93439064
58positive regulation of microtubule polymerization or depolymerization (GO:0031112)3.90240131
59synaptic vesicle endocytosis (GO:0048488)3.89971461
60phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.88606986
61monoamine transport (GO:0015844)3.85923263
62innervation (GO:0060384)3.85180745
63mitochondrial respiratory chain complex I assembly (GO:0032981)3.84369133
64NADH dehydrogenase complex assembly (GO:0010257)3.84369133
65mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.84369133
66neuron remodeling (GO:0016322)3.82343340
67ATP synthesis coupled proton transport (GO:0015986)3.80232731
68energy coupled proton transport, down electrochemical gradient (GO:0015985)3.80232731
69behavioral response to cocaine (GO:0048148)3.77844383
70regulation of synaptic vesicle exocytosis (GO:2000300)3.77107454
71neurotransmitter catabolic process (GO:0042135)3.73704719
72synaptic vesicle transport (GO:0048489)3.72586887
73establishment of synaptic vesicle localization (GO:0097480)3.72586887
74protein localization to synapse (GO:0035418)3.69286892
75cellular potassium ion homeostasis (GO:0030007)3.68266132
76mitochondrial respiratory chain complex assembly (GO:0033108)3.68103587
77tyrosine metabolic process (GO:0006570)3.62420496
78neuromuscular process controlling posture (GO:0050884)3.61504823
79negative regulation of axon guidance (GO:1902668)3.59984894
80kynurenine metabolic process (GO:0070189)3.58908954
81neurotransmitter metabolic process (GO:0042133)3.57818708
82positive regulation of amino acid transport (GO:0051957)3.55394397
83toxin metabolic process (GO:0009404)3.52039481
84negative regulation of microtubule polymerization (GO:0031115)3.48001417
85viral transcription (GO:0019083)3.47815799
86synaptic transmission, glutamatergic (GO:0035249)3.47155681
87nonmotile primary cilium assembly (GO:0035058)3.46917850
88phosphatidylcholine acyl-chain remodeling (GO:0036151)3.46365569
89regulation of neurotransmitter levels (GO:0001505)3.44326791
90translational termination (GO:0006415)3.41426190
91neurotransmitter secretion (GO:0007269)3.40811363
92regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.37010327
93regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.37010327
94indole-containing compound catabolic process (GO:0042436)3.35290553
95indolalkylamine catabolic process (GO:0046218)3.35290553
96tryptophan catabolic process (GO:0006569)3.35290553
97DNA deamination (GO:0045006)3.33765350
98negative regulation of neurotransmitter transport (GO:0051589)3.33086813
99positive regulation of cell size (GO:0045793)3.29305697
100neurotransmitter transport (GO:0006836)3.28666979
101photoreceptor cell development (GO:0042461)3.28629314
102cullin deneddylation (GO:0010388)3.27022162
103retinal ganglion cell axon guidance (GO:0031290)3.26104711
104regulation of synaptic vesicle transport (GO:1902803)3.23161732
105retinal rod cell development (GO:0046548)3.22097728
106cAMP-mediated signaling (GO:0019933)3.21748063
107protein deneddylation (GO:0000338)3.20383844
108maturation of SSU-rRNA (GO:0030490)3.19287622
109positive regulation of sodium ion transmembrane transport (GO:1902307)3.17879729
110neuron maturation (GO:0042551)3.17712918
111eye photoreceptor cell development (GO:0042462)3.17078400
112kidney morphogenesis (GO:0060993)3.17019185
113positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.16553233
114transmission of nerve impulse (GO:0019226)3.15141023
115positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.13597929
116vocalization behavior (GO:0071625)3.13154796
117positive regulation of microtubule polymerization (GO:0031116)3.11691281
118phenol-containing compound biosynthetic process (GO:0046189)3.11309253
119response to amphetamine (GO:0001975)3.07643202
120synapse assembly (GO:0007416)3.05201072
121positive regulation of heart rate (GO:0010460)3.04186265
122detection of temperature stimulus (GO:0016048)3.04158129
123positive regulation of neurotransmitter transport (GO:0051590)3.03626899
124indolalkylamine metabolic process (GO:0006586)3.02048493
125detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.01736204
126detection of temperature stimulus involved in sensory perception (GO:0050961)3.01736204
127microtubule polymerization or depolymerization (GO:0031109)2.99903730
128* regulation of dopamine secretion (GO:0014059)2.99809499
129response to auditory stimulus (GO:0010996)2.98834081
130regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.97557924
131ribosomal small subunit assembly (GO:0000028)2.97311855
132regulation of postsynaptic membrane potential (GO:0060078)2.96044758
133regulation of mononuclear cell migration (GO:0071675)2.94370484
134ATP hydrolysis coupled proton transport (GO:0015991)2.94040422
135energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.94040422
136neuron fate determination (GO:0048664)2.93206790
137regulation of voltage-gated calcium channel activity (GO:1901385)2.92542402
138response to morphine (GO:0043278)2.92221505
139regulation of vesicle fusion (GO:0031338)2.91960315
140urinary tract smooth muscle contraction (GO:0014848)2.91877179
141auditory behavior (GO:0031223)2.90322312
142benzene-containing compound metabolic process (GO:0042537)2.90315780
143tryptophan metabolic process (GO:0006568)2.90277292
144regulation of synaptic transmission, GABAergic (GO:0032228)2.90063091
145negative regulation of vascular permeability (GO:0043116)2.89732473
146multicellular organismal aging (GO:0010259)2.89573944
147neuronal action potential (GO:0019228)2.89508927
148response to ammonium ion (GO:0060359)2.89235818
149establishment of vesicle localization (GO:0051650)2.89015164
150behavioral response to pain (GO:0048266)2.88464202
151response to histamine (GO:0034776)2.88183597
152protein import into peroxisome matrix (GO:0016558)2.87697869
153retinal cone cell development (GO:0046549)2.87003083
154respiratory electron transport chain (GO:0022904)2.86738471
155electron transport chain (GO:0022900)2.85895332
156regulation of axon guidance (GO:1902667)2.84447107
157regulation of microtubule polymerization (GO:0031113)2.84093306
158mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.83040961
159cotranslational protein targeting to membrane (GO:0006613)2.82535574
160cellular protein complex disassembly (GO:0043624)2.81851277
161rRNA catabolic process (GO:0016075)2.79540415
162protein targeting to ER (GO:0045047)2.73795683
163positive regulation of multicellular organism growth (GO:0040018)2.73308660
164termination of G-protein coupled receptor signaling pathway (GO:0038032)2.72908515
165establishment of protein localization to mitochondrial membrane (GO:0090151)2.72451591
166cell differentiation in spinal cord (GO:0021515)2.69776825
167translational elongation (GO:0006414)2.68908459
168negative regulation of synaptic transmission, GABAergic (GO:0032229)2.67786694
169cellular response to interferon-beta (GO:0035458)2.67269841
170negative regulation of interleukin-1 beta production (GO:0032691)2.65987541
171SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.64586820
172bile acid and bile salt transport (GO:0015721)2.62384743
173negative regulation of transcription regulatory region DNA binding (GO:2000678)2.61359125
174limb development (GO:0060173)2.60779584
175appendage development (GO:0048736)2.60779584
176establishment of protein localization to endoplasmic reticulum (GO:0072599)2.60425454
177pyrimidine nucleobase catabolic process (GO:0006208)2.59844600
178positive regulation of gastrulation (GO:2000543)2.58124548
179respiratory chain complex IV assembly (GO:0008535)2.57966566

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.76439784
2GBX2_23144817_ChIP-Seq_PC3_Human4.17473026
3EZH2_22144423_ChIP-Seq_EOC_Human4.01378404
4TAF15_26573619_Chip-Seq_HEK293_Human3.86688341
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.30493748
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.05952539
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.93912556
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.82564716
9VDR_22108803_ChIP-Seq_LS180_Human2.65971906
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.60389958
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58564867
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54874244
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.50887541
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.48390475
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.47170605
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.40595551
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.40595551
18REST_21632747_ChIP-Seq_MESCs_Mouse2.39441966
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36461580
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.35901020
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.34502162
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.29760200
23MTF2_20144788_ChIP-Seq_MESCs_Mouse2.26755282
24CTBP1_25329375_ChIP-Seq_LNCAP_Human2.21012253
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20979309
26ZNF274_21170338_ChIP-Seq_K562_Hela2.19254523
27ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15699743
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.12450073
29REST_18959480_ChIP-ChIP_MESCs_Mouse2.09680872
30CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07694853
31EZH2_27304074_Chip-Seq_ESCs_Mouse2.03842284
32EZH2_27294783_Chip-Seq_ESCs_Mouse2.02495904
33IGF1R_20145208_ChIP-Seq_DFB_Human1.95897695
34NR3C1_23031785_ChIP-Seq_PC12_Mouse1.92666587
35DROSHA_22980978_ChIP-Seq_HELA_Human1.91472572
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.91078006
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.90465228
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.89355520
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.87977422
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86151796
41P300_19829295_ChIP-Seq_ESCs_Human1.81127025
42BCAT_22108803_ChIP-Seq_LS180_Human1.80384410
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.76427335
44SMAD4_21799915_ChIP-Seq_A2780_Human1.69378270
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.68736595
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67414830
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65369675
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61631630
49ZNF263_19887448_ChIP-Seq_K562_Human1.60999469
50CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.60539050
51IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.55345954
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54700582
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47871337
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47703811
55* TP53_22573176_ChIP-Seq_HFKS_Human1.44880487
56MYC_18940864_ChIP-ChIP_HL60_Human1.43038835
57FOXA1_25329375_ChIP-Seq_VCAP_Human1.42806306
58FOXA1_27270436_Chip-Seq_PROSTATE_Human1.42806306
59RARB_27405468_Chip-Seq_BRAIN_Mouse1.42444832
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.42246401
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.41959013
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41238516
63ETV2_25802403_ChIP-Seq_MESCs_Mouse1.40179139
64ERG_21242973_ChIP-ChIP_JURKAT_Human1.39628772
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39545612
66CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.36598177
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34648917
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34553418
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33944724
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33944724
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31732619
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31097105
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30712634
74AR_21572438_ChIP-Seq_LNCaP_Human1.28696810
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28506009
76GATA3_21878914_ChIP-Seq_MCF-7_Human1.27820835
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27371766
78CBP_20019798_ChIP-Seq_JUKART_Human1.27371766
79AR_25329375_ChIP-Seq_VCAP_Human1.26885224
80SOX2_21211035_ChIP-Seq_LN229_Gbm1.25815921
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25782398
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25697242
83PRDM14_20953172_ChIP-Seq_ESCs_Human1.25675451
84ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.25356915
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24282442
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.22966618
87PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.20712393
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19239912
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16111263
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.14753782
91P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13530768
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13377118
93STAT3_23295773_ChIP-Seq_U87_Human1.12063179
94* MYC_19829295_ChIP-Seq_ESCs_Human1.10651482
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09667432
96POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09364205
97RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07790654
98RING1B_27294783_Chip-Seq_ESCs_Mouse1.04380411
99CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04117463
100CTCF_27219007_Chip-Seq_Bcells_Human1.03709454
101ER_23166858_ChIP-Seq_MCF-7_Human1.02804052
102ELK4_26923725_Chip-Seq_MESODERM_Mouse1.00394164
103TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00080490
104RUNX2_22187159_ChIP-Seq_PCA_Human0.99531666
105SOX2_19829295_ChIP-Seq_ESCs_Human0.99221848
106NANOG_19829295_ChIP-Seq_ESCs_Human0.99221848
107RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98751835
108EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98466736
109GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97719547
110CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97389658
111ERA_21632823_ChIP-Seq_H3396_Human0.97040428
112EZH2_27294783_Chip-Seq_NPCs_Mouse0.96494057
113AR_19668381_ChIP-Seq_PC3_Human0.96450548
114EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.95353067
115EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95302350
116SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.95248726
117JUN_21703547_ChIP-Seq_K562_Human0.95224963
118NANOG_18555785_Chip-Seq_ESCs_Mouse0.95105086
119AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94480754
120SMAD4_21741376_ChIP-Seq_EPCs_Human0.93673613
121EST1_17652178_ChIP-ChIP_JURKAT_Human0.92620448
122FUS_26573619_Chip-Seq_HEK293_Human0.92589194
123MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92578075
124KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.92480949
125KDM2B_26808549_Chip-Seq_REH_Human0.91880675
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91778282
127CBX2_27304074_Chip-Seq_ESCs_Mouse0.91597784
128OCT4_20526341_ChIP-Seq_ESCs_Human0.91146186
129SMAD3_21741376_ChIP-Seq_ESCs_Human0.90701931
130YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90680573
131MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90555163
132TCF4_23295773_ChIP-Seq_U87_Human0.90267630
133P53_22387025_ChIP-Seq_ESCs_Mouse0.89974012
134CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.89086560
135CRX_20693478_ChIP-Seq_RETINA_Mouse0.88902315
136ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.88510428
137EWS_26573619_Chip-Seq_HEK293_Human0.88266652
138IRF1_19129219_ChIP-ChIP_H3396_Human0.88171729
139FOXA1_21572438_ChIP-Seq_LNCaP_Human0.88013413
140RNF2_27304074_Chip-Seq_NSC_Mouse0.86480359
141DNAJC2_21179169_ChIP-ChIP_NT2_Human0.86359414
142EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.80941090
143FLI1_21867929_ChIP-Seq_TH2_Mouse0.78692419
144OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.77397781
145CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.77351075
146GATA1_26923725_Chip-Seq_HPCs_Mouse0.77004987
147TCF4_22108803_ChIP-Seq_LS180_Human0.76908035
148KLF5_20875108_ChIP-Seq_MESCs_Mouse0.76608016

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.35210822
2MP0002735_abnormal_chemical_nociception4.46062221
3MP0001905_abnormal_dopamine_level4.13467486
4MP0006276_abnormal_autonomic_nervous3.94326884
5MP0001968_abnormal_touch/_nociception3.89358087
6MP0002736_abnormal_nociception_after3.54073086
7MP0001529_abnormal_vocalization3.17964449
8MP0004859_abnormal_synaptic_plasticity3.16040553
9MP0005551_abnormal_eye_electrophysiolog3.08502508
10MP0003635_abnormal_synaptic_transmissio3.03549901
11MP0005423_abnormal_somatic_nervous3.03157604
12MP0002102_abnormal_ear_morphology2.98042565
13MP0002139_abnormal_hepatobiliary_system2.93647789
14MP0009379_abnormal_foot_pigmentation2.86902441
15MP0002653_abnormal_ependyma_morphology2.70990610
16MP0002733_abnormal_thermal_nociception2.60376178
17MP0000566_synostosis2.56454173
18MP0009046_muscle_twitch2.53447711
19MP0003283_abnormal_digestive_organ2.44403134
20MP0002272_abnormal_nervous_system2.42402468
21MP0002064_seizures2.37655612
22MP0008877_abnormal_DNA_methylation2.30981648
23MP0002734_abnormal_mechanical_nocicepti2.28963922
24MP0002909_abnormal_adrenal_gland2.28541073
25MP0001970_abnormal_pain_threshold2.26740028
26MP0004270_analgesia2.21509880
27MP0002063_abnormal_learning/memory/cond2.20861089
28MP0002090_abnormal_vision2.18687987
29MP0009745_abnormal_behavioral_response2.14744595
30MP0001486_abnormal_startle_reflex2.14227230
31MP0002572_abnormal_emotion/affect_behav2.12002603
32MP0003959_abnormal_lean_body2.11412955
33MP0002822_catalepsy2.04545239
34MP0002277_abnormal_respiratory_mucosa2.00986759
35MP0002067_abnormal_sensory_capabilities1.96693775
36MP0003136_yellow_coat_color1.93439987
37MP0006072_abnormal_retinal_apoptosis1.92386301
38MP0004924_abnormal_behavior1.91839752
39MP0005386_behavior/neurological_phenoty1.91839752
40MP0006292_abnormal_olfactory_placode1.85520935
41MP0008875_abnormal_xenobiotic_pharmacok1.76704993
42MP0005253_abnormal_eye_physiology1.76363225
43MP0001440_abnormal_grooming_behavior1.71791376
44MP0003011_delayed_dark_adaptation1.70454635
45MP0002184_abnormal_innervation1.70266358
46MP0004858_abnormal_nervous_system1.64765240
47MP0008872_abnormal_physiological_respon1.63995915
48MP0000534_abnormal_ureter_morphology1.61515071
49MP0000026_abnormal_inner_ear1.59975677
50MP0001501_abnormal_sleep_pattern1.58966172
51MP0003122_maternal_imprinting1.55631006
52MP0001986_abnormal_taste_sensitivity1.54079972
53MP0005671_abnormal_response_to1.53955296
54MP0001502_abnormal_circadian_rhythm1.47860547
55MP0001485_abnormal_pinna_reflex1.47705154
56MP0004043_abnormal_pH_regulation1.47172692
57MP0010030_abnormal_orbit_morphology1.46851622
58MP0005084_abnormal_gallbladder_morpholo1.45255954
59MP0003878_abnormal_ear_physiology1.42302296
60MP0005377_hearing/vestibular/ear_phenot1.42302296
61MP0005535_abnormal_body_temperature1.41765875
62MP0002557_abnormal_social/conspecific_i1.34916208
63MP0005248_abnormal_Harderian_gland1.33629529
64MP0002229_neurodegeneration1.29735540
65MP0004811_abnormal_neuron_physiology1.29520035
66MP0001984_abnormal_olfaction1.29227152
67MP0002882_abnormal_neuron_morphology1.28743487
68MP0001188_hyperpigmentation1.27575852
69MP0002332_abnormal_exercise_endurance1.27108806
70MP0003868_abnormal_feces_composition1.24209412
71MP0002938_white_spotting1.23657737
72MP0001881_abnormal_mammary_gland1.21303195
73MP0000569_abnormal_digit_pigmentation1.18960057
74MP0005409_darkened_coat_color1.16966426
75MP0002638_abnormal_pupillary_reflex1.16050851
76MP0002066_abnormal_motor_capabilities/c1.14789408
77MP0003329_amyloid_beta_deposits1.14727521
78MP0004142_abnormal_muscle_tone1.14493122
79MP0005195_abnormal_posterior_eye1.14316035
80MP0000685_abnormal_immune_system1.12752456
81MP0004133_heterotaxia1.12494290
82MP0000955_abnormal_spinal_cord1.11264006
83MP0002138_abnormal_hepatobiliary_system1.10963168
84MP0010386_abnormal_urinary_bladder1.09788662
85MP0001664_abnormal_digestion1.07824696
86MP0001663_abnormal_digestive_system1.07334302
87MP0005387_immune_system_phenotype1.05539254
88MP0001790_abnormal_immune_system1.05539254
89MP0001873_stomach_inflammation1.03616075
90MP0000778_abnormal_nervous_system1.02786111
91MP0002752_abnormal_somatic_nervous1.02466025
92MP0002148_abnormal_hypersensitivity_rea1.01103869
93MP0003950_abnormal_plasma_membrane1.01012255
94MP0000639_abnormal_adrenal_gland1.00559811
95MP0003938_abnormal_ear_development0.97958137
96MP0000631_abnormal_neuroendocrine_gland0.97317581
97MP0001800_abnormal_humoral_immune0.97151203
98MP0003638_abnormal_response/metabolism_0.96718365
99MP0001293_anophthalmia0.95242760
100MP0002876_abnormal_thyroid_physiology0.94377864
101MP0002837_dystrophic_cardiac_calcinosis0.94302770
102MP0002751_abnormal_autonomic_nervous0.92961134
103MP0005499_abnormal_olfactory_system0.91898538
104MP0005394_taste/olfaction_phenotype0.91898538
105MP0000751_myopathy0.91338666
106MP0000579_abnormal_nail_morphology0.89861998
107MP0004742_abnormal_vestibular_system0.86889615
108MP0003631_nervous_system_phenotype0.85226255
109MP0001346_abnormal_lacrimal_gland0.83977606
110MP0003632_abnormal_nervous_system0.83545582
111MP0001919_abnormal_reproductive_system0.82214405
112MP0008874_decreased_physiological_sensi0.80441019
113MP0005381_digestive/alimentary_phenotyp0.80122366
114MP0000383_abnormal_hair_follicle0.79845179
115MP0003633_abnormal_nervous_system0.79771326
116MP0005187_abnormal_penis_morphology0.76426528
117MP0008569_lethality_at_weaning0.75895941
118MP0003942_abnormal_urinary_system0.75269497
119MP0003634_abnormal_glial_cell0.74672159
120MP0000372_irregular_coat_pigmentation0.74286468
121MP0004381_abnormal_hair_follicle0.73513511
122MP0003724_increased_susceptibility_to0.73416348
123MP0001177_atelectasis0.73228251
124MP0000747_muscle_weakness0.72646291
125MP0003172_abnormal_lysosome_physiology0.72136834
126MP0003879_abnormal_hair_cell0.71922310
127MP0005645_abnormal_hypothalamus_physiol0.71835644
128MP0003890_abnormal_embryonic-extraembry0.70829050
129MP0003183_abnormal_peptide_metabolism0.69863911
130MP0002928_abnormal_bile_duct0.69542545
131MP0008961_abnormal_basal_metabolism0.68832568
132MP0000538_abnormal_urinary_bladder0.68559329
133MP0001324_abnormal_eye_pigmentation0.68423978
134MP0000049_abnormal_middle_ear0.68212997
135MP0005000_abnormal_immune_tolerance0.67766520
136MP0006035_abnormal_mitochondrial_morpho0.67536975
137MP0001299_abnormal_eye_distance/0.66518744
138MP0005623_abnormal_meninges_morphology0.65135893
139MP0002069_abnormal_eating/drinking_beha0.62573198
140MP0008789_abnormal_olfactory_epithelium0.61841783
141* MP0002152_abnormal_brain_morphology0.60517288
142MP0001943_abnormal_respiration0.59910038
143MP0000013_abnormal_adipose_tissue0.58541899
144MP0005410_abnormal_fertilization0.57391971
145MP0004085_abnormal_heartbeat0.55718236
146MP0004215_abnormal_myocardial_fiber0.55494088
147MP0001963_abnormal_hearing_physiology0.51000642
148MP0004145_abnormal_muscle_electrophysio0.50471831

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)6.01177951
2Pheochromocytoma (HP:0002666)5.83640266
3Visual hallucinations (HP:0002367)5.44045453
4Neuroendocrine neoplasm (HP:0100634)5.18894981
5Facial shape deformation (HP:0011334)4.66177594
6Potter facies (HP:0002009)4.66177594
73-Methylglutaconic aciduria (HP:0003535)4.36214522
8Focal seizures (HP:0007359)4.21181334
9Failure to thrive in infancy (HP:0001531)4.20028809
10Central scotoma (HP:0000603)4.17918471
11Decreased central vision (HP:0007663)3.90676588
12Focal motor seizures (HP:0011153)3.85247038
13Hypokinesia (HP:0002375)3.80520937
14Abnormality of macular pigmentation (HP:0008002)3.77781847
15Hypothermia (HP:0002045)3.66092130
16Oligodactyly (hands) (HP:0001180)3.54205422
17Myokymia (HP:0002411)3.48040456
18Birth length less than 3rd percentile (HP:0003561)3.41348832
19Abnormal pupillary function (HP:0007686)3.38332366
20Progressive cerebellar ataxia (HP:0002073)3.32794663
21Global brain atrophy (HP:0002283)3.31656798
22Lipid accumulation in hepatocytes (HP:0006561)3.30945722
23Molar tooth sign on MRI (HP:0002419)3.29865102
24Abnormality of midbrain morphology (HP:0002418)3.29865102
25Hypoventilation (HP:0002791)3.28759604
26Abnormality of the parathyroid morphology (HP:0011766)3.27718089
27Abnormal rod and cone electroretinograms (HP:0008323)3.25926696
28Delayed gross motor development (HP:0002194)3.20694909
29Atonic seizures (HP:0010819)3.15140556
30Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.14224682
31Absence seizures (HP:0002121)3.12165439
32Dialeptic seizures (HP:0011146)3.10572160
33Scotoma (HP:0000575)3.07049271
34Gait imbalance (HP:0002141)3.01978709
35Bony spicule pigmentary retinopathy (HP:0007737)2.98019164
36Long nose (HP:0003189)2.97996957
37Pancreatic cysts (HP:0001737)2.97696963
38Epileptic encephalopathy (HP:0200134)2.96372313
39Morphological abnormality of the pyramidal tract (HP:0002062)2.96183217
40Growth hormone deficiency (HP:0000824)2.94924081
41Generalized tonic-clonic seizures (HP:0002069)2.94722833
42Increased hepatocellular lipid droplets (HP:0006565)2.94231310
43Pancreatic fibrosis (HP:0100732)2.92617820
44Cerebral hemorrhage (HP:0001342)2.88118600
45Congenital, generalized hypertrichosis (HP:0004540)2.85750197
46Tubular atrophy (HP:0000092)2.85730524
47Abnormal number of erythroid precursors (HP:0012131)2.84580928
48Neoplasm of the peripheral nervous system (HP:0100007)2.83371782
49Nephronophthisis (HP:0000090)2.83100538
50Febrile seizures (HP:0002373)2.82190130
51Diminished movement (HP:0002374)2.81675071
52Cerebral inclusion bodies (HP:0100314)2.78819187
53Hepatocellular necrosis (HP:0001404)2.78526141
54Abnormality of cells of the erythroid lineage (HP:0012130)2.77218299
55Increased corneal curvature (HP:0100692)2.77129263
56Keratoconus (HP:0000563)2.77129263
57Abnormality of the 4th metacarpal (HP:0010012)2.73306885
58Hypercortisolism (HP:0001578)2.73076878
59Muscular hypotonia of the trunk (HP:0008936)2.71138654
60Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.68453257
61Abnormality of calcium-phosphate metabolism (HP:0100530)2.66107480
62Medial flaring of the eyebrow (HP:0010747)2.65278162
63Concave nail (HP:0001598)2.65052093
64Rib fusion (HP:0000902)2.64456881
65Severe visual impairment (HP:0001141)2.62617815
66Inability to walk (HP:0002540)2.61637487
67Absent rod-and cone-mediated responses on ERG (HP:0007688)2.61381616
68Acute necrotizing encephalopathy (HP:0006965)2.59810148
69Abnormal mitochondria in muscle tissue (HP:0008316)2.59661579
70Abnormal ciliary motility (HP:0012262)2.58782723
71Protruding tongue (HP:0010808)2.58561603
72Cone-rod dystrophy (HP:0000548)2.57217487
73Dysautonomia (HP:0002459)2.54149328
74Truncal ataxia (HP:0002078)2.53653240
75Abnormal gallbladder physiology (HP:0012438)2.53651652
76Cholecystitis (HP:0001082)2.53651652
77Hypoplasia of the pons (HP:0012110)2.52445200
78Rigidity (HP:0002063)2.52356717
79Oligodactyly (HP:0012165)2.52319911
80Abnormality of the renal cortex (HP:0011035)2.49428043
81Renal cortical cysts (HP:0000803)2.49417312
82Hypogonadotrophic hypogonadism (HP:0000044)2.49204832
83Congenital primary aphakia (HP:0007707)2.44459096
84Genital tract atresia (HP:0001827)2.41834893
85Vaginal atresia (HP:0000148)2.41514897
86Hyperventilation (HP:0002883)2.40970326
87Anophthalmia (HP:0000528)2.38582080
88Mesangial abnormality (HP:0001966)2.38191490
89Postural tremor (HP:0002174)2.37997317
90Hepatic necrosis (HP:0002605)2.36292909
91True hermaphroditism (HP:0010459)2.35621240
92Retinal dysplasia (HP:0007973)2.35571157
93Abnormality of the pons (HP:0007361)2.29397434
94Increased CSF lactate (HP:0002490)2.28498973
95Nephrogenic diabetes insipidus (HP:0009806)2.27721876
96Limb hypertonia (HP:0002509)2.26237605
97Progressive macrocephaly (HP:0004481)2.26173528
98Choroideremia (HP:0001139)2.23776887
99Microvesicular hepatic steatosis (HP:0001414)2.22426997
100Spastic tetraparesis (HP:0001285)2.20020019
101Optic disc pallor (HP:0000543)2.19387009
102Absent/shortened dynein arms (HP:0200106)2.18953454
103Dynein arm defect of respiratory motile cilia (HP:0012255)2.18953454
104Ankle clonus (HP:0011448)2.18137016
105Anterior segment dysgenesis (HP:0007700)2.16414069
106Bradykinesia (HP:0002067)2.16156606
107Abnormal biliary tract physiology (HP:0012439)2.16123962
108Bile duct proliferation (HP:0001408)2.16123962
109Abolished electroretinogram (ERG) (HP:0000550)2.16109755
110Chronic hepatic failure (HP:0100626)2.15128869
111Spastic gait (HP:0002064)2.13295003
112Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.13087123
113Abnormality of the renal medulla (HP:0100957)2.12699988
114Type II lissencephaly (HP:0007260)2.12201859
115Mitochondrial inheritance (HP:0001427)2.11290600
116Hypoalbuminemia (HP:0003073)2.09425675
117Abnormal albumin level (HP:0012116)2.09425675
118Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.07089628
119Decreased electroretinogram (ERG) amplitude (HP:0000654)2.06465020
120Delusions (HP:0000746)2.05572253
121Anxiety (HP:0000739)2.04515564
122Urinary bladder sphincter dysfunction (HP:0002839)2.04495408
123Renal Fanconi syndrome (HP:0001994)2.03694024
124Depression (HP:0000716)2.02815517
125Pendular nystagmus (HP:0012043)2.02463106
126Supranuclear gaze palsy (HP:0000605)2.01102919
127Diplopia (HP:0000651)2.00946584
128Abnormality of binocular vision (HP:0011514)2.00946584
129Chorioretinal atrophy (HP:0000533)2.00857755
130Encephalitis (HP:0002383)2.00697128
131Limb dystonia (HP:0002451)10.4939182
132Anencephaly (HP:0002323)1.99422857
133Exertional dyspnea (HP:0002875)1.99167938
134Flat occiput (HP:0005469)1.98614935
135Abnormal respiratory motile cilium physiology (HP:0012261)1.96920155
136Erectile abnormalities (HP:0100639)1.95801219
137Intellectual disability, progressive (HP:0006887)1.95682530
138Disproportionate short-trunk short stature (HP:0003521)1.95590284
139Insidious onset (HP:0003587)1.95515541
140Termporal pattern (HP:0011008)1.95515541
141Polyphagia (HP:0002591)1.95161647
142Clumsiness (HP:0002312)1.95096767
143Neoplasm of the heart (HP:0100544)1.94996082
144Abnormality of pain sensation (HP:0010832)1.94813367
145Impaired pain sensation (HP:0007328)1.94813367
146Myoclonus (HP:0001336)1.94775980
147Septo-optic dysplasia (HP:0100842)1.94651111
148Reticulocytopenia (HP:0001896)1.94382999
149Increased neuronal autofluorescent lipopigment (HP:0002074)1.93584955
150Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93295507
151Abnormality of alanine metabolism (HP:0010916)1.93295507
152Hyperalaninemia (HP:0003348)1.93295507
153Partial agenesis of the corpus callosum (HP:0001338)1.93252274
154EEG with generalized epileptiform discharges (HP:0011198)1.92986947
155Progressive inability to walk (HP:0002505)1.92887382
156Dyskinesia (HP:0100660)1.92663153
157Acute encephalopathy (HP:0006846)1.91206335
158Epileptiform EEG discharges (HP:0011182)1.88117633
159B lymphocytopenia (HP:0010976)1.87682086
160Abnormal eating behavior (HP:0100738)1.86856026
161Abnormality of B cell number (HP:0010975)1.85972965
162Parakeratosis (HP:0001036)1.85650172
163Urinary urgency (HP:0000012)1.85221744
164Congenital sensorineural hearing impairment (HP:0008527)1.83187138
165Dyschromatopsia (HP:0007641)1.81105011
166Macular degeneration (HP:0000608)1.80477317
167Sclerocornea (HP:0000647)1.80408202
168Fibular hypoplasia (HP:0003038)1.79454258
169Mask-like facies (HP:0000298)1.79277629
170Increased muscle lipid content (HP:0009058)1.79087368
171Thyroid carcinoma (HP:0002890)1.78303341
172Cystic liver disease (HP:0006706)1.77996947
173Abnormal hair whorl (HP:0010721)1.77895759
174Poor suck (HP:0002033)1.77186158
175Abnormality of glycolysis (HP:0004366)1.76322223
176Esophageal atresia (HP:0002032)1.75991005
177Congenital hepatic fibrosis (HP:0002612)1.75449901

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.59670288
2MAPKAPK54.09671615
3MAP3K123.85885417
4GRK53.59101470
5TLK13.48992983
6WNK33.22237727
7MARK12.94533380
8CSNK1G32.73637071
9MINK12.62311793
10NEK12.57404222
11MAP3K92.49430406
12BCKDK2.48242320
13CSNK1G22.39136724
14PLK22.33223024
15MAP3K42.21815901
16DYRK22.02858285
17PNCK1.99177412
18MAP2K41.97675971
19NTRK11.89079700
20CSNK1G11.87415355
21TAOK31.86965215
22GRK61.85041663
23MAP2K71.84863855
24ZAK1.78607317
25BMPR1B1.71800202
26MKNK11.69185715
27CDK141.69153415
28KSR21.67729963
29RET1.63096329
30PHKG11.58938853
31PHKG21.58938853
32FES1.55674687
33INSRR1.54157511
34CDK151.53846708
35CDK181.53719306
36NEK21.53296823
37TYRO31.52662700
38NTRK31.48364093
39FGR1.48068633
40TXK1.47827253
41CASK1.45326793
42ARAF1.43496460
43CAMK2A1.42879944
44RIPK41.40586337
45CDK11A1.40479216
46CAMK2D1.38663626
47LMTK21.37107368
48STK38L1.37089432
49ADRBK21.37053122
50CDK51.30018462
51DYRK1A1.26875404
52DAPK21.26055420
53LATS21.25050685
54LIMK11.23591446
55STK391.23542628
56SIK21.22873654
57EPHA41.20392298
58WNK41.18648508
59GRK71.18641055
60PAK61.17830687
61ADRBK11.15850727
62PTK2B1.12751482
63PRKCQ1.12678865
64SYK1.12319707
65FER1.11549323
66STK381.10682465
67WEE11.07968732
68PLK41.02883314
69CAMK2B1.00997123
70MAPKAPK31.00730670
71GRK10.95121795
72MKNK20.94267988
73WNK10.92874656
74TNIK0.92620938
75NEK90.92075375
76PIK3CG0.90325033
77CHEK20.89631999
78SGK4940.88204237
79SGK2230.88204237
80PRKCG0.86676837
81EPHA30.82798648
82UHMK10.80984407
83TSSK60.78293910
84PTK20.77869536
85VRK10.77225134
86CAMK2G0.76947369
87TGFBR10.76324762
88EPHB20.73958213
89PLK30.72450981
90PAK30.71734443
91NTRK20.70346265
92SIK30.70155289
93PIK3CA0.69779860
94ROCK20.69070368
95MAP3K20.68226018
96MAP4K10.67344982
97MATK0.66754065
98KIT0.66415921
99BLK0.65893433
100KSR10.65603220
101MAPK130.65003504
102NME10.64757384
103MAPK40.64407235
104ACVR1B0.61856519
105ITK0.61366909
106ERBB30.59579710
107CAMK1G0.57285937
108MAPK150.57221748
109LYN0.55069609
110RPS6KA50.53225772
111BCR0.52981497
112CAMKK10.52804966
113PINK10.52292094
114RIPK10.51246634
115MYLK0.50752209
116TEC0.50585939
117IKBKE0.50218960
118MAP3K110.49824853
119PRKCE0.48534856
120IKBKB0.48295786
121MARK30.47534725
122SCYL20.47313261
123MAPK100.46929181
124PKN10.46330366
125PRKCB0.45360174
126CHUK0.45201832
127PRKCZ0.44127045
128PRKCA0.43373893
129AKT30.42618741
130CDC42BPA0.41256798
131KDR0.40237230
132BTK0.40190748
133PRKACA0.40101980
134FYN0.40081476
135MAP2K10.39902379
136MAP3K10.39529208
137PRKCI0.38352962
138TRPM70.38022246
139PRKAA10.36660777
140CSNK1E0.35530590
141MAP3K130.34029079
142MAPK30.33880380
143STK160.33552189
144PRKG10.33077110
145CSNK1D0.32154619
146TYK20.32114345
147RPS6KA30.31883154
148MAPK120.31681018
149SGK20.30312098
150CSNK1A10.29687269
151DAPK30.29515664
152ERBB40.29072950
153CDK190.28623022
154VRK20.28319410

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005925.77436558
2Linoleic acid metabolism_Homo sapiens_hsa005915.24028498
3Synaptic vesicle cycle_Homo sapiens_hsa047214.86812114
4Ether lipid metabolism_Homo sapiens_hsa005653.38276895
5Cocaine addiction_Homo sapiens_hsa050303.25940817
6Phototransduction_Homo sapiens_hsa047443.11844866
7Collecting duct acid secretion_Homo sapiens_hsa049662.93871259
8Parkinsons disease_Homo sapiens_hsa050122.76913980
9* Nicotine addiction_Homo sapiens_hsa050332.63837522
10Dopaminergic synapse_Homo sapiens_hsa047282.61469446
11Ribosome_Homo sapiens_hsa030102.55761120
12Amphetamine addiction_Homo sapiens_hsa050312.53028181
13Oxidative phosphorylation_Homo sapiens_hsa001902.50551518
14GABAergic synapse_Homo sapiens_hsa047272.47416651
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.30863956
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.29887224
17Serotonergic synapse_Homo sapiens_hsa047262.09773247
18Arachidonic acid metabolism_Homo sapiens_hsa005902.06516233
19Circadian entrainment_Homo sapiens_hsa047132.03906881
20Morphine addiction_Homo sapiens_hsa050322.01647766
21Insulin secretion_Homo sapiens_hsa049111.99770144
22Nitrogen metabolism_Homo sapiens_hsa009101.88385000
23Vibrio cholerae infection_Homo sapiens_hsa051101.82217439
24Glutamatergic synapse_Homo sapiens_hsa047241.79943082
25Cardiac muscle contraction_Homo sapiens_hsa042601.79559308
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.77452747
27Basal transcription factors_Homo sapiens_hsa030221.75217835
28Alzheimers disease_Homo sapiens_hsa050101.73097561
29Protein export_Homo sapiens_hsa030601.63566325
30* Cholinergic synapse_Homo sapiens_hsa047251.62874234
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.61363254
32Olfactory transduction_Homo sapiens_hsa047401.60324181
33Long-term potentiation_Homo sapiens_hsa047201.57366229
34Asthma_Homo sapiens_hsa053101.56800680
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.52821196
36Salivary secretion_Homo sapiens_hsa049701.52355801
37Renin secretion_Homo sapiens_hsa049241.48296993
38Primary immunodeficiency_Homo sapiens_hsa053401.45946424
39Fat digestion and absorption_Homo sapiens_hsa049751.45497193
40Taste transduction_Homo sapiens_hsa047421.42018837
41Ovarian steroidogenesis_Homo sapiens_hsa049131.40982001
42Calcium signaling pathway_Homo sapiens_hsa040201.39389108
43* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35750799
44RNA polymerase_Homo sapiens_hsa030201.30294801
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.27234134
46Long-term depression_Homo sapiens_hsa047301.26930203
47Tyrosine metabolism_Homo sapiens_hsa003501.23152414
48Huntingtons disease_Homo sapiens_hsa050161.22771714
49Allograft rejection_Homo sapiens_hsa053301.22394556
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.19488676
51Autoimmune thyroid disease_Homo sapiens_hsa053201.18623507
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17648075
53Gap junction_Homo sapiens_hsa045401.17150872
54Phenylalanine metabolism_Homo sapiens_hsa003601.16971746
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.16518741
56Graft-versus-host disease_Homo sapiens_hsa053321.16019439
57Aldosterone synthesis and secretion_Homo sapiens_hsa049251.14943272
58Pyruvate metabolism_Homo sapiens_hsa006201.13251097
59Oxytocin signaling pathway_Homo sapiens_hsa049211.10647751
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09999565
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09837421
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06690635
63Gastric acid secretion_Homo sapiens_hsa049711.03114148
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02153776
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00942333
66Alcoholism_Homo sapiens_hsa050340.97611059
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.96083225
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.95541783
69Caffeine metabolism_Homo sapiens_hsa002320.95051372
70Type I diabetes mellitus_Homo sapiens_hsa049400.94699006
71Tryptophan metabolism_Homo sapiens_hsa003800.94315817
72Selenocompound metabolism_Homo sapiens_hsa004500.89916121
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89258848
74GnRH signaling pathway_Homo sapiens_hsa049120.88903776
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85224201
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82719373
77Rheumatoid arthritis_Homo sapiens_hsa053230.80250576
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79994292
79Estrogen signaling pathway_Homo sapiens_hsa049150.79069868
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78519766
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77101094
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76685819
83Systemic lupus erythematosus_Homo sapiens_hsa053220.75103498
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.71961480
85Homologous recombination_Homo sapiens_hsa034400.69524666
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69433617
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68730842
88Dilated cardiomyopathy_Homo sapiens_hsa054140.68160335
89Axon guidance_Homo sapiens_hsa043600.67977313
90Thyroid hormone synthesis_Homo sapiens_hsa049180.67839094
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66804653
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66190421
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65761648
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65120471
95Inositol phosphate metabolism_Homo sapiens_hsa005620.64027897
96African trypanosomiasis_Homo sapiens_hsa051430.62784375
97ABC transporters_Homo sapiens_hsa020100.61186487
98Phagosome_Homo sapiens_hsa041450.60531453
99Fatty acid elongation_Homo sapiens_hsa000620.60378602
100Chemical carcinogenesis_Homo sapiens_hsa052040.60171847
101Staphylococcus aureus infection_Homo sapiens_hsa051500.58815304
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58505628
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58252515
104Melanogenesis_Homo sapiens_hsa049160.54755063
105Pancreatic secretion_Homo sapiens_hsa049720.52473171
106Sulfur metabolism_Homo sapiens_hsa009200.51938058
107Bile secretion_Homo sapiens_hsa049760.51877071
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50430524
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.49871329
110Fatty acid biosynthesis_Homo sapiens_hsa000610.49082416
111Glucagon signaling pathway_Homo sapiens_hsa049220.48310168
112Antigen processing and presentation_Homo sapiens_hsa046120.46877499
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44901593
114Type II diabetes mellitus_Homo sapiens_hsa049300.44055696
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43947962
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43242759
117Oocyte meiosis_Homo sapiens_hsa041140.43025098
118Basal cell carcinoma_Homo sapiens_hsa052170.42605001
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.40918566
120Circadian rhythm_Homo sapiens_hsa047100.39742723
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39596631
122cAMP signaling pathway_Homo sapiens_hsa040240.39500530
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38348544
124Dorso-ventral axis formation_Homo sapiens_hsa043200.38223445
125Hematopoietic cell lineage_Homo sapiens_hsa046400.37844005
126Sphingolipid metabolism_Homo sapiens_hsa006000.37785758
127Peroxisome_Homo sapiens_hsa041460.37382401
128Metabolic pathways_Homo sapiens_hsa011000.37362919
129Sulfur relay system_Homo sapiens_hsa041220.36786199
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.36754501
131Histidine metabolism_Homo sapiens_hsa003400.36023374
132Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35097106
133NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33308356
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.32426241
135Ras signaling pathway_Homo sapiens_hsa040140.28294970
136Mineral absorption_Homo sapiens_hsa049780.27772542
137Thyroid cancer_Homo sapiens_hsa052160.27023331
138Endocytosis_Homo sapiens_hsa041440.25406748
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24611649
140Galactose metabolism_Homo sapiens_hsa000520.24195371
141Vitamin B6 metabolism_Homo sapiens_hsa007500.23749697
142Steroid biosynthesis_Homo sapiens_hsa001000.22754440
143Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22144011
144MAPK signaling pathway_Homo sapiens_hsa040100.21458720
145Purine metabolism_Homo sapiens_hsa002300.21236755
146Biosynthesis of amino acids_Homo sapiens_hsa012300.20312519
1472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.20188612
148Fructose and mannose metabolism_Homo sapiens_hsa000510.20042310
149Pyrimidine metabolism_Homo sapiens_hsa002400.19864417
150Thyroid hormone signaling pathway_Homo sapiens_hsa049190.19787241
151Proteasome_Homo sapiens_hsa030500.19635554
152T cell receptor signaling pathway_Homo sapiens_hsa046600.19503168
153Butanoate metabolism_Homo sapiens_hsa006500.19426926
154Retinol metabolism_Homo sapiens_hsa008300.19084644
155ErbB signaling pathway_Homo sapiens_hsa040120.17190099
156Regulation of autophagy_Homo sapiens_hsa041400.15494588
157Glycerolipid metabolism_Homo sapiens_hsa005610.15446991
158Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.14875375
159Rap1 signaling pathway_Homo sapiens_hsa040150.14523077
160Renin-angiotensin system_Homo sapiens_hsa046140.13658138

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