CHRNA9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1midgut development (GO:0007494)5.16062730
2purine nucleobase biosynthetic process (GO:0009113)5.11178704
3ribosome assembly (GO:0042255)5.09346946
4nucleobase biosynthetic process (GO:0046112)4.89238800
5mitotic metaphase plate congression (GO:0007080)4.76369759
6DNA replication initiation (GO:0006270)4.55048510
7V(D)J recombination (GO:0033151)4.51452095
8negative regulation of thymocyte apoptotic process (GO:0070244)4.46490906
9DNA replication checkpoint (GO:0000076)4.46219522
10somatic diversification of immune receptors via somatic mutation (GO:0002566)4.35260665
11somatic hypermutation of immunoglobulin genes (GO:0016446)4.35260665
12cellular protein complex localization (GO:0034629)4.25361407
13regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.25011114
14homocysteine metabolic process (GO:0050667)4.20133162
15DNA strand elongation involved in DNA replication (GO:0006271)4.18572744
16regulation of translational fidelity (GO:0006450)4.10575130
17protein complex localization (GO:0031503)4.03713281
18formation of translation preinitiation complex (GO:0001731)4.03649904
19DNA replication-dependent nucleosome organization (GO:0034723)4.03644797
20DNA replication-dependent nucleosome assembly (GO:0006335)4.03644797
21nuclear pore organization (GO:0006999)4.02177306
22IMP biosynthetic process (GO:0006188)4.01539660
23protein localization to kinetochore (GO:0034501)4.00780535
24regulation of spindle organization (GO:0090224)3.99461820
25urea cycle (GO:0000050)3.98953297
26ribosome biogenesis (GO:0042254)3.97703765
27DNA strand elongation (GO:0022616)3.96033528
28metaphase plate congression (GO:0051310)3.93935828
29regulation of posttranscriptional gene silencing (GO:0060147)3.88564224
30regulation of gene silencing by miRNA (GO:0060964)3.88564224
31regulation of gene silencing by RNA (GO:0060966)3.88564224
32mitotic sister chromatid cohesion (GO:0007064)3.86484315
33regulation of helicase activity (GO:0051095)3.78706174
34protein K6-linked ubiquitination (GO:0085020)3.76980008
35nuclear pore complex assembly (GO:0051292)3.76777356
36non-recombinational repair (GO:0000726)3.74063282
37double-strand break repair via nonhomologous end joining (GO:0006303)3.74063282
38hepatocyte differentiation (GO:0070365)3.73377389
39mitotic nuclear envelope disassembly (GO:0007077)3.71186682
40maturation of SSU-rRNA (GO:0030490)3.70895567
41rRNA modification (GO:0000154)3.70277192
42telomere maintenance via semi-conservative replication (GO:0032201)3.68575213
43positive regulation of chromosome segregation (GO:0051984)3.67586760
44regulation of mitotic spindle organization (GO:0060236)3.62162096
45regulation of translational termination (GO:0006449)3.60600000
46regulation of nuclear cell cycle DNA replication (GO:0033262)3.57925501
47regulation of histone H3-K9 methylation (GO:0051570)3.53576752
48urea metabolic process (GO:0019627)3.51226358
49somatic cell DNA recombination (GO:0016444)3.50905156
50somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.50905156
51IMP metabolic process (GO:0046040)3.50269122
52negative regulation of gene silencing (GO:0060969)3.49545485
53establishment of chromosome localization (GO:0051303)3.48664016
54regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.48628006
55chromatin remodeling at centromere (GO:0031055)3.48094284
56glutamine metabolic process (GO:0006541)3.46166833
57sister chromatid segregation (GO:0000819)3.45745669
58nuclear envelope disassembly (GO:0051081)3.44231716
59membrane disassembly (GO:0030397)3.44231716
60CENP-A containing nucleosome assembly (GO:0034080)3.43709909
61somatic diversification of immune receptors (GO:0002200)3.42962633
62regulation of DNA damage checkpoint (GO:2000001)3.41570090
63ribonucleoprotein complex biogenesis (GO:0022613)3.40770728
64telomere maintenance via recombination (GO:0000722)3.39871932
65DNA replication-independent nucleosome assembly (GO:0006336)3.39317743
66DNA replication-independent nucleosome organization (GO:0034724)3.39317743
67establishment of apical/basal cell polarity (GO:0035089)3.37020552
68protein localization to chromosome, centromeric region (GO:0071459)3.36500230
69nucleobase-containing small molecule interconversion (GO:0015949)3.30563906
70citrulline biosynthetic process (GO:0019240)3.28988056
71paraxial mesoderm development (GO:0048339)3.28759888
72positive regulation of vascular permeability (GO:0043117)3.28736083
73DNA unwinding involved in DNA replication (GO:0006268)3.28651774
74establishment of integrated proviral latency (GO:0075713)3.25383774
75notochord development (GO:0030903)3.25044965
76L-serine metabolic process (GO:0006563)3.24482215
77regulation of gene silencing (GO:0060968)3.23754004
78mitotic recombination (GO:0006312)3.21601483
79transcription from RNA polymerase I promoter (GO:0006360)3.20710470
80transcription elongation from RNA polymerase I promoter (GO:0006362)3.20415135
81folic acid-containing compound biosynthetic process (GO:0009396)3.18824866
82mitotic chromosome condensation (GO:0007076)3.16751604
83histone exchange (GO:0043486)3.16076574
84regulation of chromatin silencing (GO:0031935)3.15189101
85rRNA processing (GO:0006364)3.15089724
86transcription-coupled nucleotide-excision repair (GO:0006283)3.14334867
87establishment of viral latency (GO:0019043)3.14111437
88telomere maintenance via telomere lengthening (GO:0010833)3.13856963
89mitotic sister chromatid segregation (GO:0000070)3.12908979
90regulation of centrosome cycle (GO:0046605)3.12689536
91transcription initiation from RNA polymerase I promoter (GO:0006361)3.09782372
92protein localization to chromosome (GO:0034502)3.09168733
93tRNA aminoacylation for protein translation (GO:0006418)3.09011994
94negative regulation of histone methylation (GO:0031061)3.08672078
95hemidesmosome assembly (GO:0031581)3.08559103
96attachment of spindle microtubules to kinetochore (GO:0008608)3.07735284
97regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.06915148
98rRNA metabolic process (GO:0016072)3.06782158
99termination of RNA polymerase I transcription (GO:0006363)3.06152211
100regulation of centriole replication (GO:0046599)3.05589915
101regulation of chromosome segregation (GO:0051983)3.04032706
102spindle checkpoint (GO:0031577)3.03584831
103ribosomal small subunit assembly (GO:0000028)3.02996508
104rRNA methylation (GO:0031167)3.02908619
105DNA geometric change (GO:0032392)3.02785378
106regulation of spindle checkpoint (GO:0090231)3.02401637
107ribosomal large subunit biogenesis (GO:0042273)3.02342462
108tRNA aminoacylation (GO:0043039)3.01123158
109amino acid activation (GO:0043038)3.01123158
110negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.00921308
111nitrogen cycle metabolic process (GO:0071941)2.98921393
112maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.98059825
113inner cell mass cell proliferation (GO:0001833)2.96622967
114regulation of cell cycle checkpoint (GO:1901976)2.95831278
115positive regulation of cell cycle checkpoint (GO:1901978)2.95562483
116negative regulation of chromosome segregation (GO:0051985)2.93889672
117transcription elongation from RNA polymerase III promoter (GO:0006385)2.93751164
118termination of RNA polymerase III transcription (GO:0006386)2.93751164
119spliceosomal snRNP assembly (GO:0000387)2.93664900
120kinetochore organization (GO:0051383)2.92569065
121negative regulation of mitotic sister chromatid separation (GO:2000816)2.90619112
122negative regulation of mitotic sister chromatid segregation (GO:0033048)2.90619112
123negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.90619112
124negative regulation of sister chromatid segregation (GO:0033046)2.90619112
125maturation of 5.8S rRNA (GO:0000460)2.90575575
126regulation of translational elongation (GO:0006448)2.90361128
127regulation of centrosome duplication (GO:0010824)2.90358020
128folic acid metabolic process (GO:0046655)2.90011784
129nucleotide-excision repair, DNA gap filling (GO:0006297)2.89697940
130mitotic spindle checkpoint (GO:0071174)2.88834012
131citrulline metabolic process (GO:0000052)2.88543835
132regulation of translation in response to stress (GO:0043555)2.88250538
133intestinal epithelial cell development (GO:0060576)2.86696153
134somatic recombination of immunoglobulin gene segments (GO:0016447)2.86672965
135pore complex assembly (GO:0046931)2.85664201
136mitotic spindle assembly checkpoint (GO:0007094)2.85449461
137mismatch repair (GO:0006298)2.85444715
138regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.85079480
139regulation of double-strand break repair via homologous recombination (GO:0010569)2.84165423
140regulation of mitotic metaphase/anaphase transition (GO:0030071)2.84010193
141nuclear envelope organization (GO:0006998)2.83513589
142DNA duplex unwinding (GO:0032508)2.82981510

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.80065724
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.02690001
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.84407045
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.73727249
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.36793093
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.22393810
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.80425485
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.72296867
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.67732388
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.66841030
11NANOG_18555785_ChIP-Seq_MESCs_Mouse2.61099099
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.49586200
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.49294093
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.46887225
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.44410338
16SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.43241482
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.35215157
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.29581891
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.25207187
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.21435617
21KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.14790062
22KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.14790062
23KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.14790062
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.14306427
25CREB1_15753290_ChIP-ChIP_HEK293T_Human2.13276453
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.12954940
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.05973293
28KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.05688012
29TP63_17297297_ChIP-ChIP_HaCaT_Human1.98791523
30XRN2_22483619_ChIP-Seq_HELA_Human1.98654940
31NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.98010793
32* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.97482519
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96776257
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.95116435
35AR_21909140_ChIP-Seq_LNCAP_Human1.91977518
36VDR_23849224_ChIP-Seq_CD4+_Human1.90936360
37POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.84574041
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78348338
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.76499995
40STAT3_1855785_ChIP-Seq_MESCs_Mouse1.76219998
41* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.74177574
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.73080899
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.71124180
44SOX2_18555785_ChIP-Seq_MESCs_Mouse1.70964764
45MYC_22102868_ChIP-Seq_BL_Human1.70637367
46NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.70382875
47PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.70005007
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.67401984
49TCF3_18692474_ChIP-Seq_MEFs_Mouse1.66105432
50FOXP3_21729870_ChIP-Seq_TREG_Human1.57913677
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54906269
52CLOCK_20551151_ChIP-Seq_293T_Human1.52855721
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49996501
54DCP1A_22483619_ChIP-Seq_HELA_Human1.49438414
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.49025305
56GABP_19822575_ChIP-Seq_HepG2_Human1.42546207
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41372413
58CIITA_25753668_ChIP-Seq_RAJI_Human1.39843149
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39297103
60HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.36892283
61ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.35050316
62TCF3_18692474_ChIP-Seq_MESCs_Mouse1.34418629
63TTF2_22483619_ChIP-Seq_HELA_Human1.34414283
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34368319
65NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.34000119
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33393938
67SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.32318438
68KDM5A_27292631_Chip-Seq_BREAST_Human1.32170774
69CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.31675971
70* ELK1_19687146_ChIP-ChIP_HELA_Human1.30780937
71KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30681656
72THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29324006
73RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25942881
74NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25264357
75SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.24613637
76NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.24294756
77TRIM28_21343339_ChIP-Seq_HEK293_Human1.23067300
78SOX2_18692474_ChIP-Seq_MEFs_Mouse1.21520280
79SOX17_20123909_ChIP-Seq_XEN_Mouse1.20999325
80ZNF263_19887448_ChIP-Seq_K562_Human1.20489206
81NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.18665677
82OCT4_18692474_ChIP-Seq_MEFs_Mouse1.16503536
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16217722
84KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.16032902
85MYC_18940864_ChIP-ChIP_HL60_Human1.15531893
86NANOG_18692474_ChIP-Seq_MEFs_Mouse1.15254922
87E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13430825
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12674682
89ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11551239
90ELF1_17652178_ChIP-ChIP_JURKAT_Human1.11129515
91ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10070522
92* NANOG_21062744_ChIP-ChIP_HESCs_Human1.09727873
93NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.09160938
94EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.09033999
95FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08312554
96TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.07527329
97SOX2_18692474_ChIP-Seq_MESCs_Mouse1.07379358
98NANOG_16153702_ChIP-ChIP_HESCs_Human1.07328048
99TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05443914
100TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04857062
101TP63_19390658_ChIP-ChIP_HaCaT_Human1.04128584
102* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02416950
103* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02024144
104* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02024144
105POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.01967912
106KAP1_27257070_Chip-Seq_ESCs_Mouse0.99100857
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98438620
108BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98143520
109NANOG_18692474_ChIP-Seq_MESCs_Mouse0.97798668
110SOX2_16153702_ChIP-ChIP_HESCs_Human0.97371435
111DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96472484
112PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96250856
113CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96050109
114SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95999094
115CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94939539
116TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94428453
117SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93928799
118ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93888615
119SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92723454
120SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92420272
121PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92026297
122CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.91895676
123HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91204457
124CHD1_26751641_Chip-Seq_LNCaP_Human0.90638342
125TFEB_21752829_ChIP-Seq_HELA_Human0.90203917
126POU5F1_16518401_ChIP-PET_MESCs_Mouse0.88857059
127CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86571676
128SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82846523
129* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.81946581
130CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.81260088
131ERG_20887958_ChIP-Seq_HPC-7_Mouse0.80805677

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.29865457
2MP0003693_abnormal_embryo_hatching5.24703660
3MP0003111_abnormal_nucleus_morphology4.23690782
4MP0008057_abnormal_DNA_replication4.10183524
5MP0004957_abnormal_blastocyst_morpholog3.99007334
6MP0003077_abnormal_cell_cycle3.61952394
7MP0008058_abnormal_DNA_repair3.20846821
8MP0000579_abnormal_nail_morphology3.20087709
9MP0001849_ear_inflammation2.75988007
10MP0008007_abnormal_cellular_replicative2.48988939
11MP0003283_abnormal_digestive_organ2.45757730
12MP0001730_embryonic_growth_arrest2.43190873
13MP0003718_maternal_effect2.22836759
14MP0003806_abnormal_nucleotide_metabolis2.16464375
15MP0005623_abnormal_meninges_morphology2.16169394
16MP0000350_abnormal_cell_proliferation2.15868447
17MP0003763_abnormal_thymus_physiology2.13712256
18MP0010352_gastrointestinal_tract_polyps2.13056646
19MP0002877_abnormal_melanocyte_morpholog2.06091862
20MP0004233_abnormal_muscle_weight2.05154507
21MP0009379_abnormal_foot_pigmentation2.00241369
22MP0000703_abnormal_thymus_morphology1.93874300
23MP0003123_paternal_imprinting1.91709827
24MP0003786_premature_aging1.91541581
25MP0003705_abnormal_hypodermis_morpholog1.88513503
26MP0005671_abnormal_response_to1.85527711
27MP0008932_abnormal_embryonic_tissue1.84714039
28MP0010307_abnormal_tumor_latency1.80441446
29MP0010234_abnormal_vibrissa_follicle1.78379069
30MP0002060_abnormal_skin_morphology1.77243510
31MP0002009_preneoplasia1.73532374
32MP0002697_abnormal_eye_size1.73013887
33MP0002796_impaired_skin_barrier1.64440228
34MP0001672_abnormal_embryogenesis/_devel1.58158407
35MP0005380_embryogenesis_phenotype1.58158407
36MP0003937_abnormal_limbs/digits/tail_de1.57817396
37MP0001697_abnormal_embryo_size1.55387150
38MP0002132_abnormal_respiratory_system1.54475207
39MP0000516_abnormal_urinary_system1.53046319
40MP0005367_renal/urinary_system_phenotyp1.53046319
41MP0000013_abnormal_adipose_tissue1.52360670
42MP0003941_abnormal_skin_development1.51809002
43MP0005076_abnormal_cell_differentiation1.51214882
44MP0010030_abnormal_orbit_morphology1.50604471
45MP0005501_abnormal_skin_physiology1.49383353
46MP0002085_abnormal_embryonic_tissue1.47672430
47MP0004272_abnormal_basement_membrane1.47092712
48MP0000537_abnormal_urethra_morphology1.45864201
49MP0008877_abnormal_DNA_methylation1.45299733
50MP0000762_abnormal_tongue_morphology1.43369956
51MP0002080_prenatal_lethality1.42373596
52MP0009333_abnormal_splenocyte_physiolog1.41526531
53MP0001545_abnormal_hematopoietic_system1.40849798
54MP0005397_hematopoietic_system_phenotyp1.40849798
55MP0002019_abnormal_tumor_incidence1.38795776
56MP0002084_abnormal_developmental_patter1.35663662
57MP0000685_abnormal_immune_system1.35465560
58MP0004197_abnormal_fetal_growth/weight/1.35271408
59MP0009697_abnormal_copulation1.34421399
60MP0010678_abnormal_skin_adnexa1.33485880
61MP0004133_heterotaxia1.33481339
62MP0003984_embryonic_growth_retardation1.33202040
63MP0009672_abnormal_birth_weight1.32088023
64MP0000490_abnormal_crypts_of1.30055966
65MP0002086_abnormal_extraembryonic_tissu1.29568973
66MP0002088_abnormal_embryonic_growth/wei1.29469745
67MP0004808_abnormal_hematopoietic_stem1.28029444
68MP0002722_abnormal_immune_system1.25556017
69MP0002653_abnormal_ependyma_morphology1.24075525
70MP0002398_abnormal_bone_marrow1.23748735
71MP0001661_extended_life_span1.22299642
72MP0000003_abnormal_adipose_tissue1.19794975
73MP0003453_abnormal_keratinocyte_physiol1.18440667
74MP0002210_abnormal_sex_determination1.16697815
75MP0000313_abnormal_cell_death1.16215136
76MP0009278_abnormal_bone_marrow1.14852623
77MP0003890_abnormal_embryonic-extraembry1.14457604
78MP0000383_abnormal_hair_follicle1.13744417
79MP0002006_tumorigenesis1.13106867
80MP0008438_abnormal_cutaneous_collagen1.12222633
81MP0003567_abnormal_fetal_cardiomyocyte1.12107235
82MP0001177_atelectasis1.10332144
83MP0002166_altered_tumor_susceptibility1.07585196
84MP0001915_intracranial_hemorrhage1.06584075
85MP0000689_abnormal_spleen_morphology1.06325940
86MP0002396_abnormal_hematopoietic_system1.05762603
87MP0000858_altered_metastatic_potential1.05149583
88MP0005409_darkened_coat_color1.03404362
89MP0010771_integument_phenotype1.02416305
90MP0009053_abnormal_anal_canal1.02050905
91MP0001145_abnormal_male_reproductive1.00813588
92MP0002095_abnormal_skin_pigmentation0.99164804
93MP0001286_abnormal_eye_development0.98673720
94MP0001835_abnormal_antigen_presentation0.97265215
95MP0002234_abnormal_pharynx_morphology0.97101934
96MP0001216_abnormal_epidermal_layer0.95497586
97MP0006035_abnormal_mitochondrial_morpho0.95157468
98MP0002111_abnormal_tail_morphology0.95025704
99MP0002233_abnormal_nose_morphology0.93788469
100MP0001293_anophthalmia0.92771242
101MP0000428_abnormal_craniofacial_morphol0.91645697
102MP0002160_abnormal_reproductive_system0.91378377
103MP0003119_abnormal_digestive_system0.91323881
104MP0000716_abnormal_immune_system0.89481213
105MP0001929_abnormal_gametogenesis0.89056989
106MP0003136_yellow_coat_color0.88806445
107MP0002938_white_spotting0.88693344
108MP0003755_abnormal_palate_morphology0.87973422
109MP0001348_abnormal_lacrimal_gland0.87804555
110MP0010155_abnormal_intestine_physiology0.87540033
111MP0001800_abnormal_humoral_immune0.86741161
112MP0002092_abnormal_eye_morphology0.86722177
113MP0004947_skin_inflammation0.86049696
114MP0000653_abnormal_sex_gland0.84645255
115MP0004185_abnormal_adipocyte_glucose0.84335179
116MP0005275_abnormal_skin_tensile0.82214331
117MP0002429_abnormal_blood_cell0.81983347
118MP0000733_abnormal_muscle_development0.80870230
119MP0000627_abnormal_mammary_gland0.80289892
120MP0000432_abnormal_head_morphology0.78485223
121MP0005384_cellular_phenotype0.78470668
122MP0005197_abnormal_uvea_morphology0.77949869
123MP0005377_hearing/vestibular/ear_phenot0.77590055
124MP0003878_abnormal_ear_physiology0.77590055
125MP0005621_abnormal_cell_physiology0.77443478
126MP0001188_hyperpigmentation0.77117197
127MP0001879_abnormal_lymphatic_vessel0.75388198
128MP0003935_abnormal_craniofacial_develop0.75247034
129MP0003385_abnormal_body_wall0.75049091
130MP0000377_abnormal_hair_follicle0.74818913
131MP0005395_other_phenotype0.73761579
132MP0000358_abnormal_cell_content/0.73559381
133MP0001485_abnormal_pinna_reflex0.72251129
134MP0003186_abnormal_redox_activity0.72032794
135MP0005389_reproductive_system_phenotype0.71366722
136MP0005375_adipose_tissue_phenotype0.70406859
137MP0003221_abnormal_cardiomyocyte_apopto0.70263415
138MP0003566_abnormal_cell_adhesion0.69276052
139MP0001119_abnormal_female_reproductive0.68171755
140MP0009703_decreased_birth_body0.68004637
141MP0000467_abnormal_esophagus_morphology0.67456105
142MP0001243_abnormal_dermal_layer0.67033055
143MP0002075_abnormal_coat/hair_pigmentati0.66236346
144MP0003448_altered_tumor_morphology0.65224463
145MP0003950_abnormal_plasma_membrane0.64464784
146MP0005023_abnormal_wound_healing0.64354071
147MP0002127_abnormal_cardiovascular_syste0.64334630
148MP0001853_heart_inflammation0.63475556
149MP0000477_abnormal_intestine_morphology0.63188453
150MP0001340_abnormal_eyelid_morphology0.63090796
151MP0006036_abnormal_mitochondrial_physio0.62783559
152MP0003936_abnormal_reproductive_system0.62675952
153MP0003115_abnormal_respiratory_system0.62587782
154MP0008770_decreased_survivor_rate0.61454944
155MP0005266_abnormal_metabolism0.61207533
156MP0008260_abnormal_autophagy0.60450651

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.79746736
2B lymphocytopenia (HP:0010976)5.25184164
3Abnormality of B cell number (HP:0010975)5.25184164
4T lymphocytopenia (HP:0005403)5.16696438
5Abnormality of T cell number (HP:0011839)4.95303922
6Breast hypoplasia (HP:0003187)4.76447559
7Severe combined immunodeficiency (HP:0004430)4.75491205
8Thyroiditis (HP:0100646)4.61707926
9Eosinophilia (HP:0001880)4.56271510
10Combined immunodeficiency (HP:0005387)4.37037095
11Carpal bone hypoplasia (HP:0001498)4.30674182
12Panhypogammaglobulinemia (HP:0003139)4.23343108
13Hypoplasia of the thymus (HP:0000778)4.23306781
14Impulsivity (HP:0100710)3.94832223
15Granulocytopenia (HP:0001913)3.88252281
16Onycholysis (HP:0001806)3.69106935
17Abnormality of the labia minora (HP:0012880)3.65402909
18Patellar aplasia (HP:0006443)3.44032123
19Abnormality of eosinophils (HP:0001879)3.43797676
20Ependymoma (HP:0002888)3.42555943
21Ankyloglossia (HP:0010296)3.40532479
22Cerebral hypomyelination (HP:0006808)3.38166730
23Recurrent viral infections (HP:0004429)3.35172879
24Milia (HP:0001056)3.25260341
25Aplasia/Hypoplasia of the patella (HP:0006498)3.21722171
26Erythroderma (HP:0001019)3.06692821
27Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.02769359
28IgG deficiency (HP:0004315)3.00990403
29Absent radius (HP:0003974)2.97734117
30Abnormality of T cells (HP:0002843)2.90068467
31Selective tooth agenesis (HP:0001592)2.85861772
32Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.83432064
33Abnormality of alanine metabolism (HP:0010916)2.83432064
34Hyperalaninemia (HP:0003348)2.83432064
35Cellular immunodeficiency (HP:0005374)2.81093727
36Rough bone trabeculation (HP:0100670)2.80114872
37Absent forearm bone (HP:0003953)2.77802851
38Aplasia involving forearm bones (HP:0009822)2.77802851
39Abnormality of oral frenula (HP:0000190)2.73340521
40Agnosia (HP:0010524)2.72234278
41Chromsome breakage (HP:0040012)2.71172659
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.66335886
43Leukocytosis (HP:0001974)2.64351647
44Oral leukoplakia (HP:0002745)2.61817299
45Hypoproteinemia (HP:0003075)2.59776494
46Colon cancer (HP:0003003)2.58286721
47Microvesicular hepatic steatosis (HP:0001414)2.48771174
48Supernumerary spleens (HP:0009799)2.47417987
49Spastic diplegia (HP:0001264)2.47319474
50Abnormality of the anterior horn cell (HP:0006802)2.46790179
51Degeneration of anterior horn cells (HP:0002398)2.46790179
52Missing ribs (HP:0000921)2.46440386
53Increased nuchal translucency (HP:0010880)2.45997233
54Deviation of the thumb (HP:0009603)2.42918829
55Calcaneovalgus deformity (HP:0001848)2.40715562
56Medulloblastoma (HP:0002885)2.40460660
57Absent thumb (HP:0009777)2.39654415
58Stenosis of the external auditory canal (HP:0000402)2.34143529
59Microretrognathia (HP:0000308)2.33064096
60Abnormality of chromosome stability (HP:0003220)2.32353778
61Abnormality of the preputium (HP:0100587)2.31429058
62Atrophic scars (HP:0001075)2.30963217
63CNS hypomyelination (HP:0003429)2.29959430
64Hyperglycinemia (HP:0002154)2.28570765
65Abnormalities of placenta or umbilical cord (HP:0001194)2.27151543
66Premature ovarian failure (HP:0008209)2.26875426
67Basal cell carcinoma (HP:0002671)2.26575308
68Meckel diverticulum (HP:0002245)2.24903999
69Lymphoma (HP:0002665)2.23195443
70Termporal pattern (HP:0011008)2.22734137
71Insidious onset (HP:0003587)2.22734137
72Glossoptosis (HP:0000162)2.21966269
73Aplasia/hypoplasia of the humerus (HP:0006507)2.21491470
74Abnormality of the calcaneus (HP:0008364)2.20952477
75Short nail (HP:0001799)2.20496477
76Elbow flexion contracture (HP:0002987)2.19759921
77Cerebral edema (HP:0002181)2.17601629
78Osteolytic defects of the phalanges of the hand (HP:0009771)2.17193601
79Osteolytic defects of the hand bones (HP:0009699)2.17193601
80Deep philtrum (HP:0002002)2.16536095
81Megaloblastic anemia (HP:0001889)2.15019046
82Atresia of the external auditory canal (HP:0000413)2.14336418
83Hyperglycinuria (HP:0003108)2.12553372
84Reticulocytopenia (HP:0001896)2.11735654
85Anal stenosis (HP:0002025)2.11366573
86Abnormality of placental membranes (HP:0011409)2.11030333
87Amniotic constriction ring (HP:0009775)2.11030333
88Neoplasm of the pancreas (HP:0002894)2.10568205
89Asymmetry of the thorax (HP:0001555)2.10029053
90Cerebellar dysplasia (HP:0007033)2.09070035
91Rhabdomyosarcoma (HP:0002859)2.08216970
92Abnormality of methionine metabolism (HP:0010901)2.06198825
93Renal duplication (HP:0000075)2.06033238
94Abnormality of the astrocytes (HP:0100707)2.05462055
95Astrocytoma (HP:0009592)2.05462055
96Facial cleft (HP:0002006)2.04674698
97Abnormality of serum amino acid levels (HP:0003112)2.04646300
98Deformed tarsal bones (HP:0008119)2.04068259
99Biliary tract neoplasm (HP:0100574)2.02808478
100Abnormality of the ileum (HP:0001549)2.01603275
101Trismus (HP:0000211)2.01491888
102Overriding aorta (HP:0002623)2.00745479
103Sparse lateral eyebrow (HP:0005338)2.00442573
104Prominent nose (HP:0000448)2.00359249
105Premature rupture of membranes (HP:0001788)2.00189014
106Fragile nails (HP:0001808)1.99986724
107Cleft eyelid (HP:0000625)1.99876567
108Aplasia/Hypoplasia of the sacrum (HP:0008517)1.99794942
109Ureteral duplication (HP:0000073)1.99339225
110Abnormality of cells of the erythroid lineage (HP:0012130)1.98483151
111Abnormality of the umbilical cord (HP:0010881)1.98471983
112Recurrent fungal infections (HP:0002841)1.98276168
113Aplasia/Hypoplasia of the uvula (HP:0010293)1.97879307
114Horseshoe kidney (HP:0000085)1.97257790
115Bone marrow hypocellularity (HP:0005528)1.96837164
116Amaurosis fugax (HP:0100576)1.96153476
117Abnormality of glutamine family amino acid metabolism (HP:0010902)1.95911998
118Abnormal lung lobation (HP:0002101)1.95353978
119Multiple enchondromatosis (HP:0005701)1.95334612
120Neoplasm of the oral cavity (HP:0100649)1.94199819
121Pterygium (HP:0001059)1.93289908
122Abnormal trabecular bone morphology (HP:0100671)1.92531887
123Aplasia/Hypoplasia of the thymus (HP:0010515)1.92193762
124Progressive external ophthalmoplegia (HP:0000590)1.90096576
125Overlapping toe (HP:0001845)1.89036511
126Entropion (HP:0000621)1.87973022
127Myelodysplasia (HP:0002863)1.87280334
128Spinal cord compression (HP:0002176)1.86855569
129Ectopic kidney (HP:0000086)1.86720208
130Breast aplasia (HP:0100783)1.86429766
131Abnormal number of incisors (HP:0011064)1.86419849
132Progressive muscle weakness (HP:0003323)1.86075672
133Vertebral clefting (HP:0008428)1.85816270
134Nephroblastoma (Wilms tumor) (HP:0002667)1.85765650
135Abnormality of the carotid arteries (HP:0005344)1.85613024
136Duplicated collecting system (HP:0000081)1.85607366
137Tracheoesophageal fistula (HP:0002575)1.84961414
138Fused cervical vertebrae (HP:0002949)1.84505109
139Hypoplasia of the capital femoral epiphysis (HP:0003090)1.83981139
140Abnormal cartilage morphology (HP:0002763)1.83833510
141Small intestinal stenosis (HP:0012848)1.83451623
142Duodenal stenosis (HP:0100867)1.83451623
143Vertebral arch anomaly (HP:0008438)1.82908361
144Glioma (HP:0009733)1.82844744
145Sensory axonal neuropathy (HP:0003390)1.82802191
146Breech presentation (HP:0001623)1.82483760
147Sloping forehead (HP:0000340)1.82027450
148Plantar hyperkeratosis (HP:0007556)1.81175619
149Aplasia/Hypoplasia of the sternum (HP:0006714)1.80622584
150Secondary amenorrhea (HP:0000869)1.80068159
151Cortical dysplasia (HP:0002539)1.79968391
152Short humerus (HP:0005792)1.79199086
153Relative macrocephaly (HP:0004482)1.78810239
154Alkalosis (HP:0001948)1.78361582
155Muscle fiber atrophy (HP:0100295)1.78315213
156Proximal placement of thumb (HP:0009623)1.77825225
157Abnormality of pain sensation (HP:0010832)1.77512956
158Impaired pain sensation (HP:0007328)1.77512956
159Irregular epiphyses (HP:0010582)1.76956856
160Aplasia cutis congenita (HP:0001057)1.76780592
161Hyperacusis (HP:0010780)1.75577874
162Aplasia/Hypoplasia of the breasts (HP:0010311)1.75556139
163Increased serum pyruvate (HP:0003542)1.74764803
164Recurrent corneal erosions (HP:0000495)1.73123150
165Abnormality of glycolysis (HP:0004366)1.72171435
166Oligodactyly (hands) (HP:0001180)1.71820302
167Embryonal renal neoplasm (HP:0011794)1.71268961
168Exercise-induced muscle cramps (HP:0003710)1.70327200
169Hypobetalipoproteinemia (HP:0003563)1.69589530
170Large earlobe (HP:0009748)1.65927735
171Volvulus (HP:0002580)1.65836467
172Nail dystrophy (HP:0008404)1.64619136
173Partial agenesis of the corpus callosum (HP:0001338)1.63954881
174Macrocytic anemia (HP:0001972)1.62799042

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.20079688
2WEE14.19943970
3NEK23.22148730
4CDC72.97916341
5NEK12.89133429
6TSSK62.68288955
7MST1R2.62418462
8SRPK12.46293334
9TTK2.45972077
10EPHA22.45333779
11CDK122.30667651
12RPS6KB22.20876928
13ERBB42.06859110
14PLK12.06058833
15EIF2AK32.03762518
16EIF2AK12.03750073
17PASK1.97506436
18MET1.97506082
19PLK41.96598926
20DYRK31.85757833
21PLK31.79147082
22NME21.77991942
23MKNK21.69506320
24ALK1.66540789
25STK161.58718318
26ATR1.55470331
27MST41.34209238
28CHEK21.32183237
29CDK71.31395794
30AKT31.29934774
31AURKB1.29536635
32MAP4K11.26632901
33MAP3K81.24609097
34MAPKAPK31.24060935
35TXK1.23244840
36CDK41.21929000
37STK101.20123160
38ACVR1B1.19991147
39MKNK11.18796497
40PNCK1.17201518
41BRD41.16098416
42CHEK11.15469798
43PRKCI1.15062930
44NEK61.15003727
45TESK21.14453867
46VRK11.12378708
47CDK61.07359769
48BRSK21.07194170
49ICK1.06481826
50STK41.06107086
51NTRK10.96093635
52ZAK0.95876273
53PIM10.95635037
54STK38L0.95420612
55MELK0.94152009
56YES10.93773125
57PINK10.93424939
58CDK20.91783221
59AURKA0.89164769
60CSNK1A1L0.86981675
61ATM0.86476418
62CSNK1G30.80809491
63STK390.78538326
64PKN20.77607257
65TLK10.77233696
66RPS6KA40.75760713
67MAPKAPK50.74989333
68VRK20.74814227
69LATS20.72131627
70BRSK10.72001817
71PDGFRA0.71681701
72PDK40.70577601
73PDK30.70577601
74CSNK2A20.69799841
75SMG10.69742987
76TAF10.69236407
77ERBB30.69160811
78GRK60.68672370
79LMTK20.64296162
80MAP3K90.63377500
81EIF2AK20.63151470
82CLK10.61970260
83PDK20.61886889
84OXSR10.61294015
85CSNK1D0.60795401
86MAP3K100.60468430
87TYK20.59817563
88CDK10.59750891
89STK30.59007743
90CSNK1G10.57835566
91LATS10.57127155
92BMX0.56682460
93CSNK1E0.56204239
94EEF2K0.55378560
95LRRK20.55279627
96PAK20.53628667
97BMPR1B0.52191294
98CSNK2A10.51836991
99BRAF0.50614835
100CCNB10.50374932
101WNK40.47032322
102STK240.46493580
103PBK0.46366880
104MAPK110.45622140
105ZAP700.44995703
106PAK40.44627061
107PRKDC0.43684815
108PIM20.43539008
109FGFR10.43233328
110SYK0.42857095
111PTK20.42722301
112RPS6KA50.41936040
113IRAK30.39878596
114MTOR0.39850914
115CSNK1G20.39677838
116CDK80.38405472
117MAPK70.38248192
118PRPF4B0.36841614
119CDK30.36211450
120PDGFRB0.35481153
121FLT30.35237066
122RAF10.35188102
123BCR0.34211471
124ABL20.33476782
125PAK10.33187313
126NME10.31584553
127TTN0.31167719
128SCYL20.23980646
129MAP3K140.22563609
130MAPK140.22212770
131AKT20.21433912

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.32728137
2Mismatch repair_Homo sapiens_hsa034304.02609744
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.98908941
4RNA polymerase_Homo sapiens_hsa030203.86581106
5RNA transport_Homo sapiens_hsa030133.26708797
6Non-homologous end-joining_Homo sapiens_hsa034503.15088857
7Primary immunodeficiency_Homo sapiens_hsa053403.09339391
8Spliceosome_Homo sapiens_hsa030403.01047136
9Proteasome_Homo sapiens_hsa030502.78409886
10Cell cycle_Homo sapiens_hsa041102.70803673
11Nucleotide excision repair_Homo sapiens_hsa034202.67761204
12Base excision repair_Homo sapiens_hsa034102.64828707
13Ribosome_Homo sapiens_hsa030102.64505803
14One carbon pool by folate_Homo sapiens_hsa006702.55310230
15Pyrimidine metabolism_Homo sapiens_hsa002402.50657170
16Homologous recombination_Homo sapiens_hsa034402.31057134
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.13955502
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.08426884
19Basal transcription factors_Homo sapiens_hsa030221.97039829
20Fanconi anemia pathway_Homo sapiens_hsa034601.95583550
21Arginine biosynthesis_Homo sapiens_hsa002201.95179632
22Vitamin B6 metabolism_Homo sapiens_hsa007501.86946889
23RNA degradation_Homo sapiens_hsa030181.68386269
24Antigen processing and presentation_Homo sapiens_hsa046121.64637764
25mRNA surveillance pathway_Homo sapiens_hsa030151.62889058
26p53 signaling pathway_Homo sapiens_hsa041151.62014280
27Nitrogen metabolism_Homo sapiens_hsa009101.61845867
28Pyruvate metabolism_Homo sapiens_hsa006201.49975954
29Purine metabolism_Homo sapiens_hsa002301.39135924
30Epstein-Barr virus infection_Homo sapiens_hsa051691.33543592
31Protein export_Homo sapiens_hsa030601.32382221
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30970443
33Alcoholism_Homo sapiens_hsa050341.27314457
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26449835
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.25835589
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22404877
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10233559
38ECM-receptor interaction_Homo sapiens_hsa045121.09145618
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.04437924
40Cysteine and methionine metabolism_Homo sapiens_hsa002700.99516908
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98696363
42Oocyte meiosis_Homo sapiens_hsa041140.98336568
43Central carbon metabolism in cancer_Homo sapiens_hsa052300.97925440
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.94582083
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93888578
46Steroid biosynthesis_Homo sapiens_hsa001000.92174825
47Biosynthesis of amino acids_Homo sapiens_hsa012300.91405488
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89658172
49Viral carcinogenesis_Homo sapiens_hsa052030.89442592
50T cell receptor signaling pathway_Homo sapiens_hsa046600.88642367
51Thyroid cancer_Homo sapiens_hsa052160.85954061
52Pentose phosphate pathway_Homo sapiens_hsa000300.83884551
53Folate biosynthesis_Homo sapiens_hsa007900.83430008
54Herpes simplex infection_Homo sapiens_hsa051680.82932019
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81500677
56HTLV-I infection_Homo sapiens_hsa051660.76813265
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75494915
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74514716
59N-Glycan biosynthesis_Homo sapiens_hsa005100.72494218
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.69669124
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.66620095
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63413388
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.62580824
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62354144
65Systemic lupus erythematosus_Homo sapiens_hsa053220.61445993
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59835422
67Galactose metabolism_Homo sapiens_hsa000520.58384125
68MicroRNAs in cancer_Homo sapiens_hsa052060.53322728
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52817758
70Regulation of autophagy_Homo sapiens_hsa041400.52725124
71FoxO signaling pathway_Homo sapiens_hsa040680.50872533
72Hematopoietic cell lineage_Homo sapiens_hsa046400.49847797
73Sulfur metabolism_Homo sapiens_hsa009200.49760947
74Notch signaling pathway_Homo sapiens_hsa043300.49731929
75Hippo signaling pathway_Homo sapiens_hsa043900.49118118
76Basal cell carcinoma_Homo sapiens_hsa052170.48505779
77Hedgehog signaling pathway_Homo sapiens_hsa043400.48458566
78Sulfur relay system_Homo sapiens_hsa041220.47884704
79Small cell lung cancer_Homo sapiens_hsa052220.47134750
80Colorectal cancer_Homo sapiens_hsa052100.46099630
81Lysine degradation_Homo sapiens_hsa003100.45863470
82Prostate cancer_Homo sapiens_hsa052150.43661780
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43257547
84PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39248578
85Proteoglycans in cancer_Homo sapiens_hsa052050.38012510
86Focal adhesion_Homo sapiens_hsa045100.37415544
87Acute myeloid leukemia_Homo sapiens_hsa052210.36620418
88Carbon metabolism_Homo sapiens_hsa012000.36583053
89Apoptosis_Homo sapiens_hsa042100.36334720
90Pancreatic cancer_Homo sapiens_hsa052120.35874690
91TGF-beta signaling pathway_Homo sapiens_hsa043500.35295993
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33547807
93mTOR signaling pathway_Homo sapiens_hsa041500.32463386
94Selenocompound metabolism_Homo sapiens_hsa004500.32318683
95Adherens junction_Homo sapiens_hsa045200.31791011
96Measles_Homo sapiens_hsa051620.31642430
97Metabolic pathways_Homo sapiens_hsa011000.30347737
98Fructose and mannose metabolism_Homo sapiens_hsa000510.29807670
99Propanoate metabolism_Homo sapiens_hsa006400.29759153
100Wnt signaling pathway_Homo sapiens_hsa043100.27801683
101Chronic myeloid leukemia_Homo sapiens_hsa052200.27407617
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26687305
103Parkinsons disease_Homo sapiens_hsa050120.26485975
104Endometrial cancer_Homo sapiens_hsa052130.26108828
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24644062
106Glioma_Homo sapiens_hsa052140.24271346
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.23667940
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.22098813
109Vitamin digestion and absorption_Homo sapiens_hsa049770.22076603
110Hepatitis B_Homo sapiens_hsa051610.21436080
111Pathways in cancer_Homo sapiens_hsa052000.21129131
112Glutathione metabolism_Homo sapiens_hsa004800.19878198
113Influenza A_Homo sapiens_hsa051640.19675822
114Huntingtons disease_Homo sapiens_hsa050160.18108194
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.17800041
116Vibrio cholerae infection_Homo sapiens_hsa051100.17759467
117Alzheimers disease_Homo sapiens_hsa050100.17229201
118HIF-1 signaling pathway_Homo sapiens_hsa040660.17055921
119Legionellosis_Homo sapiens_hsa051340.16862947
120Phenylalanine metabolism_Homo sapiens_hsa003600.15825045
121beta-Alanine metabolism_Homo sapiens_hsa004100.14802930
122B cell receptor signaling pathway_Homo sapiens_hsa046620.14522372
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.14151192
124Bladder cancer_Homo sapiens_hsa052190.14019922
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.13610286
126Allograft rejection_Homo sapiens_hsa053300.13433489
127Dorso-ventral axis formation_Homo sapiens_hsa043200.12290608
128Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.12040643
129Inositol phosphate metabolism_Homo sapiens_hsa005620.09977618
130Viral myocarditis_Homo sapiens_hsa054160.09866983
131Arginine and proline metabolism_Homo sapiens_hsa003300.08829751
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.08631454
133Melanoma_Homo sapiens_hsa052180.08353163
134Graft-versus-host disease_Homo sapiens_hsa053320.08112643
135Tight junction_Homo sapiens_hsa045300.07084145
136Circadian rhythm_Homo sapiens_hsa047100.06454323

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