CHRNB4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sympathetic nervous system development (GO:0048485)9.70621994
2norepinephrine metabolic process (GO:0042415)7.83331021
3behavioral response to ethanol (GO:0048149)7.72357043
4catecholamine biosynthetic process (GO:0042423)6.57583935
5catechol-containing compound biosynthetic process (GO:0009713)6.57583935
6dopamine metabolic process (GO:0042417)6.05275939
7neurotransmitter catabolic process (GO:0042135)5.91251712
8ganglion development (GO:0061548)5.66416096
9activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)5.62842695
10catecholamine transport (GO:0051937)5.41403094
11* synaptic transmission, cholinergic (GO:0007271)5.08272135
12catecholamine metabolic process (GO:0006584)4.56893824
13catechol-containing compound metabolic process (GO:0009712)4.56893824
14pyrimidine nucleobase catabolic process (GO:0006208)4.35125947
15response to pain (GO:0048265)4.34602289
16daunorubicin metabolic process (GO:0044597)4.34408705
17polyketide metabolic process (GO:0030638)4.34408705
18doxorubicin metabolic process (GO:0044598)4.34408705
19dopaminergic neuron differentiation (GO:0071542)4.31691689
20fucose catabolic process (GO:0019317)4.17021605
21L-fucose metabolic process (GO:0042354)4.17021605
22L-fucose catabolic process (GO:0042355)4.17021605
23response to pheromone (GO:0019236)4.12792646
24cellular response to nicotine (GO:0071316)4.03778610
25phenol-containing compound biosynthetic process (GO:0046189)4.01370784
26dopamine biosynthetic process (GO:0042416)4.01053121
27maternal behavior (GO:0042711)3.96799027
28positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.73462329
29indolalkylamine metabolic process (GO:0006586)3.69402830
30nucleobase catabolic process (GO:0046113)3.67830093
31positive regulation of transcription regulatory region DNA binding (GO:2000679)3.66150228
32detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.63189245
33* neuromuscular synaptic transmission (GO:0007274)3.61363954
34piRNA metabolic process (GO:0034587)3.59349025
35indole-containing compound catabolic process (GO:0042436)3.58578720
36indolalkylamine catabolic process (GO:0046218)3.58578720
37tryptophan catabolic process (GO:0006569)3.58578720
38parental behavior (GO:0060746)3.57685842
39regulation of respiratory gaseous exchange (GO:0043576)3.56607711
40epithelial cilium movement (GO:0003351)3.56376669
41response to water (GO:0009415)3.54646902
42response to amphetamine (GO:0001975)3.54533658
43platelet dense granule organization (GO:0060155)3.53760074
44epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.53449252
45kynurenine metabolic process (GO:0070189)3.52893744
46negative regulation of telomere maintenance (GO:0032205)3.50592511
47monoamine transport (GO:0015844)3.48231996
48cell migration in hindbrain (GO:0021535)3.46266231
49regulation of secondary heart field cardioblast proliferation (GO:0003266)3.46207419
50regulation of cardioblast proliferation (GO:0003264)3.46207419
51detection of light stimulus involved in visual perception (GO:0050908)3.36760988
52detection of light stimulus involved in sensory perception (GO:0050962)3.36760988
53photoreceptor cell development (GO:0042461)3.33717901
54eye photoreceptor cell development (GO:0042462)3.33647712
55protein heterotetramerization (GO:0051290)3.30464032
56opioid receptor signaling pathway (GO:0038003)3.30459546
57gamma-aminobutyric acid transport (GO:0015812)3.25997626
58tryptophan metabolic process (GO:0006568)3.14566587
59cellular ketone body metabolic process (GO:0046950)3.13561347
60auditory receptor cell stereocilium organization (GO:0060088)3.12207510
61inner ear receptor stereocilium organization (GO:0060122)3.10982094
62photoreceptor cell maintenance (GO:0045494)3.10842418
63neural tube formation (GO:0001841)3.10233774
64outflow tract septum morphogenesis (GO:0003148)3.09127501
65cilium movement (GO:0003341)3.08987621
66* response to nicotine (GO:0035094)3.06252238
67DNA deamination (GO:0045006)3.06014257
68axoneme assembly (GO:0035082)3.03848550
69retinal cone cell development (GO:0046549)3.03092045
70positive regulation of neurotransmitter transport (GO:0051590)3.00026586
71negative regulation of striated muscle cell apoptotic process (GO:0010664)2.97995203
72indole-containing compound metabolic process (GO:0042430)2.97783114
73energy homeostasis (GO:0097009)2.95435326
74positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.93961901
75ketone body metabolic process (GO:1902224)2.90235372
76neurotransmitter biosynthetic process (GO:0042136)2.88152738
77water-soluble vitamin biosynthetic process (GO:0042364)2.87486732
78regulation of action potential (GO:0098900)2.87312813
79transmission of nerve impulse (GO:0019226)2.86189022
80central nervous system neuron axonogenesis (GO:0021955)2.85512517
81positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.85183694
82multicellular organism reproduction (GO:0032504)2.84264266
83regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.83975032
84regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.83975032
85cardiac chamber formation (GO:0003207)2.83201148
86regulation of vesicle fusion (GO:0031338)2.82964069
87oxygen transport (GO:0015671)2.82037346
88spinal cord motor neuron differentiation (GO:0021522)2.81092610
89regulation of cilium movement (GO:0003352)2.79700400
90G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.79149635
91DNA methylation involved in gamete generation (GO:0043046)2.78983963
92protein polyglutamylation (GO:0018095)2.78843466
93regulation of respiratory system process (GO:0044065)2.77792699
94neuronal action potential (GO:0019228)2.77295832
95peristalsis (GO:0030432)2.77043501
96regulation of rhodopsin mediated signaling pathway (GO:0022400)2.75642788
97sperm motility (GO:0030317)2.75396885
98cilium organization (GO:0044782)2.74610270
99kidney morphogenesis (GO:0060993)2.74462299
100negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.74086705
101negative regulation of microtubule polymerization (GO:0031115)2.73334347
102mitochondrial respiratory chain complex I assembly (GO:0032981)2.72467046
103NADH dehydrogenase complex assembly (GO:0010257)2.72467046
104mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.72467046
105protein complex biogenesis (GO:0070271)2.72419134
106reflex (GO:0060004)2.72213504
107sulfation (GO:0051923)2.71750690
108facial nerve structural organization (GO:0021612)2.71492664
109primary amino compound metabolic process (GO:1901160)2.71301136
110ubiquinone biosynthetic process (GO:0006744)2.71089081
111rRNA catabolic process (GO:0016075)2.70734899
112serotonin metabolic process (GO:0042428)2.70198491
113ubiquinone metabolic process (GO:0006743)2.69375793
114cilium assembly (GO:0042384)2.68873372
115preassembly of GPI anchor in ER membrane (GO:0016254)2.68552694
116cilium morphogenesis (GO:0060271)2.68301030
117cilium or flagellum-dependent cell motility (GO:0001539)2.67511778
118DNA double-strand break processing (GO:0000729)2.66769663
119cardiac right ventricle morphogenesis (GO:0003215)2.66550955
120rhodopsin mediated signaling pathway (GO:0016056)2.66024795
121enteric nervous system development (GO:0048484)2.64618820
122regulation of short-term neuronal synaptic plasticity (GO:0048172)2.63777976
123mannosylation (GO:0097502)2.62962086
124cranial nerve development (GO:0021545)2.61531829
125protein K11-linked deubiquitination (GO:0035871)2.60392731
126regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.60376543
127somite development (GO:0061053)2.58413546
128negative regulation of cytosolic calcium ion concentration (GO:0051481)2.58382512
129acrosome reaction (GO:0007340)2.57086339
130positive regulation of vesicle fusion (GO:0031340)2.56076485
131cardiac ventricle formation (GO:0003211)2.55907651
132male meiosis I (GO:0007141)2.55773720
133positive regulation of fatty acid transport (GO:2000193)2.55754673
134amine catabolic process (GO:0009310)2.55678475
135cellular biogenic amine catabolic process (GO:0042402)2.55678475
136proline transport (GO:0015824)2.54890091
137regulation of glucokinase activity (GO:0033131)2.54474649
138regulation of hexokinase activity (GO:1903299)2.54474649
139regulation of mesoderm development (GO:2000380)2.52301084
140mitochondrial respiratory chain complex assembly (GO:0033108)2.51964360
141cellular anion homeostasis (GO:0030002)2.51539688
142positive regulation of prostaglandin secretion (GO:0032308)2.51207340
143respiratory chain complex IV assembly (GO:0008535)2.50736929
144cornea development in camera-type eye (GO:0061303)2.49811497
145reciprocal meiotic recombination (GO:0007131)2.49065983
146reciprocal DNA recombination (GO:0035825)2.49065983
147retina layer formation (GO:0010842)2.48373261
148iron-sulfur cluster assembly (GO:0016226)2.48283075
149metallo-sulfur cluster assembly (GO:0031163)2.48283075
150dopamine transport (GO:0015872)2.48100132
151protein localization to cilium (GO:0061512)2.47879975
152replication fork processing (GO:0031297)2.47516854
153synapsis (GO:0007129)2.47063654
154cAMP catabolic process (GO:0006198)2.46920047
155tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.46668853
156RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.46668853
157somite rostral/caudal axis specification (GO:0032525)2.46621602
158central nervous system projection neuron axonogenesis (GO:0021952)2.46216139
159regulation of meiosis I (GO:0060631)2.45575767
160multicellular organismal reproductive behavior (GO:0033057)2.45235464
161aminoglycoside antibiotic metabolic process (GO:0030647)2.45066977
162cell differentiation in spinal cord (GO:0021515)2.44705681
163* regulation of neurotransmitter secretion (GO:0046928)2.44613045
164* regulation of neurotransmitter transport (GO:0051588)2.44602168
165negative regulation of reactive oxygen species metabolic process (GO:2000378)2.43447904
166cranial nerve structural organization (GO:0021604)2.43194999
167protein-cofactor linkage (GO:0018065)2.42955853
168alkaloid metabolic process (GO:0009820)2.42566486
169protein neddylation (GO:0045116)2.41243119
170regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.41193541
171nonmotile primary cilium assembly (GO:0035058)2.39550079
172positive regulation of potassium ion transmembrane transport (GO:1901381)2.37292999
173eye photoreceptor cell differentiation (GO:0001754)2.35431094
174photoreceptor cell differentiation (GO:0046530)2.35431094
175retinal rod cell development (GO:0046548)2.35077449
176parturition (GO:0007567)2.33963506
177adult feeding behavior (GO:0008343)2.33512257
178positive regulation of protein depolymerization (GO:1901881)2.33394523
179positive regulation of gastrulation (GO:2000543)2.32419921
180glycine transport (GO:0015816)2.31993460
181fear response (GO:0042596)2.31118236
182phenol-containing compound catabolic process (GO:0019336)13.7271760
183* behavioral response to nicotine (GO:0035095)10.1012013

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.32867084
2ZNF274_21170338_ChIP-Seq_K562_Hela3.93182091
3GBX2_23144817_ChIP-Seq_PC3_Human3.40623718
4BMI1_23680149_ChIP-Seq_NPCS_Mouse2.96769559
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.63349170
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.32197826
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.29212341
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.27739265
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.26980865
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19203177
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.19174612
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.12123603
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.09711798
14IGF1R_20145208_ChIP-Seq_DFB_Human2.08971142
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.02990313
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.01252038
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.00565493
18CBX2_27304074_Chip-Seq_ESCs_Mouse1.99391494
19ER_23166858_ChIP-Seq_MCF-7_Human1.89680333
20FUS_26573619_Chip-Seq_HEK293_Human1.88603331
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86645694
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.83272838
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81441868
24* REST_21632747_ChIP-Seq_MESCs_Mouse1.80866408
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.80558572
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.78861931
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.75298804
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.75298804
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75084477
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74852102
31P300_19829295_ChIP-Seq_ESCs_Human1.73182435
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72989409
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71805132
34TAF15_26573619_Chip-Seq_HEK293_Human1.71625245
35RNF2_27304074_Chip-Seq_NSC_Mouse1.71066425
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70659209
37NR3C1_23031785_ChIP-Seq_PC12_Mouse1.66443181
38AR_21572438_ChIP-Seq_LNCaP_Human1.61997319
39CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58403363
40VDR_22108803_ChIP-Seq_LS180_Human1.58271338
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.57549945
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53964311
43TP53_22573176_ChIP-Seq_HFKS_Human1.52736631
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.52651171
45IRF1_19129219_ChIP-ChIP_H3396_Human1.52220578
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.51578492
47* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50121134
48CBP_20019798_ChIP-Seq_JUKART_Human1.48011823
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48011823
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46583529
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45837062
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45837062
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45242417
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44846091
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43082980
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42319768
57SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.41719719
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41429212
59* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41260093
60SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40784738
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40347857
62SMAD4_21799915_ChIP-Seq_A2780_Human1.39972730
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.39085710
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37239309
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.35906494
66RNF2_27304074_Chip-Seq_ESCs_Mouse1.35703780
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.31506882
68NANOG_19829295_ChIP-Seq_ESCs_Human1.31090184
69SOX2_19829295_ChIP-Seq_ESCs_Human1.31090184
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.30152224
71REST_18959480_ChIP-ChIP_MESCs_Mouse1.29740739
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.26537642
73GABP_17652178_ChIP-ChIP_JURKAT_Human1.25931396
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25788338
75* FOXA1_25329375_ChIP-Seq_VCAP_Human1.25481473
76* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25481473
77* AR_25329375_ChIP-Seq_VCAP_Human1.25276650
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.24729592
79* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24724411
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.24179644
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24098158
82MYC_18940864_ChIP-ChIP_HL60_Human1.23754598
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23537912
84NCOR_22424771_ChIP-Seq_293T_Human1.22994321
85SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22517642
86EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.22195834
87GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22127309
88CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.21746016
89* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21048082
90* BCAT_22108803_ChIP-Seq_LS180_Human1.21046096
91KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20826012
92MTF2_20144788_ChIP-Seq_MESCs_Mouse1.20281050
93EZH2_27294783_Chip-Seq_NPCs_Mouse1.20056407
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19084078
95GATA3_21878914_ChIP-Seq_MCF-7_Human1.18765736
96EWS_26573619_Chip-Seq_HEK293_Human1.17845078
97SALL1_21062744_ChIP-ChIP_HESCs_Human1.17546979
98SMAD4_21741376_ChIP-Seq_EPCs_Human1.17256325
99E2F1_18555785_Chip-Seq_ESCs_Mouse1.16345272
100CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.16171207
101STAT3_18555785_Chip-Seq_ESCs_Mouse1.14549017
102CMYC_18555785_Chip-Seq_ESCs_Mouse1.14285582
103CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12588648
104RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12409536
105TAL1_26923725_Chip-Seq_HPCs_Mouse1.11282851
106* RUNX2_22187159_ChIP-Seq_PCA_Human1.11096428
107P53_22387025_ChIP-Seq_ESCs_Mouse1.10954581
108* TCF4_22108803_ChIP-Seq_LS180_Human1.10758646
109PRDM14_20953172_ChIP-Seq_ESCs_Human1.09278314
110TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08920122
111NMYC_18555785_Chip-Seq_ESCs_Mouse1.08531683
112FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08224453
113SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07121391
114SMAD_19615063_ChIP-ChIP_OVARY_Human1.07075730
115RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06145685
116EST1_17652178_ChIP-ChIP_JURKAT_Human1.05742460
117STAT3_23295773_ChIP-Seq_U87_Human1.05506493
118AR_20517297_ChIP-Seq_VCAP_Human1.04988134
119HOXB7_26014856_ChIP-Seq_BT474_Human1.04760720
120TCF4_23295773_ChIP-Seq_U87_Human1.04756778
121GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.03416257
122ERA_21632823_ChIP-Seq_H3396_Human1.01276149
123OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00564826
124SOX2_18555785_Chip-Seq_ESCs_Mouse1.00421593
125KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.00398267
126MYC_19829295_ChIP-Seq_ESCs_Human1.00001767
127DROSHA_22980978_ChIP-Seq_HELA_Human0.99474253
128SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98679540
129P300_18555785_Chip-Seq_ESCs_Mouse0.96472934
130NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96013317
131EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95829024
132JUN_21703547_ChIP-Seq_K562_Human0.94330613
133PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93912516
134ZFX_18555785_Chip-Seq_ESCs_Mouse0.93079862
135YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92305307
136SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.91789482
137RUNX1_27457419_Chip-Seq_LIVER_Mouse0.90642465
138NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.89656863

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy8.20178632
2MP0002638_abnormal_pupillary_reflex7.12574786
3* MP0010386_abnormal_urinary_bladder4.58641618
4MP0006292_abnormal_olfactory_placode3.26520570
5MP0006276_abnormal_autonomic_nervous2.86121377
6MP0003880_abnormal_central_pattern2.58692809
7MP0002751_abnormal_autonomic_nervous2.53578240
8MP0000372_irregular_coat_pigmentation2.50974327
9MP0001905_abnormal_dopamine_level2.38246759
10MP0005646_abnormal_pituitary_gland2.10511365
11MP0003195_calcinosis2.07492829
12MP0002734_abnormal_mechanical_nocicepti1.98246316
13MP0001529_abnormal_vocalization1.97507183
14* MP0000538_abnormal_urinary_bladder1.96877827
15MP0003941_abnormal_skin_development1.96222462
16MP0006072_abnormal_retinal_apoptosis1.94521816
17MP0000569_abnormal_digit_pigmentation1.86671374
18MP0009046_muscle_twitch1.86241822
19MP0005551_abnormal_eye_electrophysiolog1.85618204
20MP0003011_delayed_dark_adaptation1.84676196
21MP0003787_abnormal_imprinting1.82046044
22MP0001440_abnormal_grooming_behavior1.81260557
23MP0001188_hyperpigmentation1.76968121
24MP0004885_abnormal_endolymph1.75842997
25MP0004270_analgesia1.74863796
26MP0005645_abnormal_hypothalamus_physiol1.74026124
27MP0005171_absent_coat_pigmentation1.73858895
28MP0001970_abnormal_pain_threshold1.72850214
29MP0005253_abnormal_eye_physiology1.71627957
30MP0002102_abnormal_ear_morphology1.70851319
31MP0003136_yellow_coat_color1.70244751
32MP0002163_abnormal_gland_morphology1.70028301
33MP0004742_abnormal_vestibular_system1.68880379
34MP0002733_abnormal_thermal_nociception1.65964935
35MP0004142_abnormal_muscle_tone1.64447624
36MP0002837_dystrophic_cardiac_calcinosis1.61141670
37MP0004858_abnormal_nervous_system1.55723133
38MP0001485_abnormal_pinna_reflex1.55087373
39MP0005197_abnormal_uvea_morphology1.54945887
40* MP0009745_abnormal_behavioral_response1.54021780
41MP0009697_abnormal_copulation1.52605934
42MP0000566_synostosis1.51943390
43MP0003890_abnormal_embryonic-extraembry1.44459183
44MP0008875_abnormal_xenobiotic_pharmacok1.42319781
45MP0002127_abnormal_cardiovascular_syste1.40956193
46MP0002735_abnormal_chemical_nociception1.38620802
47MP0002572_abnormal_emotion/affect_behav1.38496225
48MP0008872_abnormal_physiological_respon1.35664020
49MP0005386_behavior/neurological_phenoty1.34970260
50MP0004924_abnormal_behavior1.34970260
51MP0004133_heterotaxia1.32389517
52MP0000427_abnormal_hair_cycle1.30385539
53MP0002234_abnormal_pharynx_morphology1.29093245
54MP0000778_abnormal_nervous_system1.27128398
55MP0001968_abnormal_touch/_nociception1.26317107
56MP0004145_abnormal_muscle_electrophysio1.25630266
57MP0005410_abnormal_fertilization1.25158593
58MP0004043_abnormal_pH_regulation1.24474252
59MP0002938_white_spotting1.23927744
60MP0002184_abnormal_innervation1.23122473
61MP0001501_abnormal_sleep_pattern1.23071410
62MP0002160_abnormal_reproductive_system1.21668203
63MP0002909_abnormal_adrenal_gland1.21061496
64MP0004147_increased_porphyrin_level1.21002852
65MP0003646_muscle_fatigue1.19703939
66MP0000049_abnormal_middle_ear1.18364638
67MP0008789_abnormal_olfactory_epithelium1.17788811
68MP0005379_endocrine/exocrine_gland_phen1.17786332
69MP0002272_abnormal_nervous_system1.14412955
70MP0003635_abnormal_synaptic_transmissio1.13372756
71MP0005394_taste/olfaction_phenotype1.12443329
72MP0005499_abnormal_olfactory_system1.12443329
73MP0002557_abnormal_social/conspecific_i1.10432700
74MP0005167_abnormal_blood-brain_barrier1.08633667
75MP0001984_abnormal_olfaction1.08539635
76MP0002928_abnormal_bile_duct1.08511738
77MP0003698_abnormal_male_reproductive1.05512474
78MP0008004_abnormal_stomach_pH1.04557780
79MP0008995_early_reproductive_senescence1.03592738
80MP0002752_abnormal_somatic_nervous1.02973625
81MP0005084_abnormal_gallbladder_morpholo1.02828990
82MP0002063_abnormal_learning/memory/cond1.01913939
83MP0008961_abnormal_basal_metabolism0.99053233
84MP0003137_abnormal_impulse_conducting0.97852740
85MP0003718_maternal_effect0.97141557
86MP0001919_abnormal_reproductive_system0.94560183
87MP0005391_vision/eye_phenotype0.93900157
88MP0000631_abnormal_neuroendocrine_gland0.93559210
89MP0001502_abnormal_circadian_rhythm0.92872616
90MP0005423_abnormal_somatic_nervous0.92827715
91MP0002067_abnormal_sensory_capabilities0.91780468
92MP0003122_maternal_imprinting0.91446717
93MP0003283_abnormal_digestive_organ0.88699670
94MP0002697_abnormal_eye_size0.88519919
95MP0005085_abnormal_gallbladder_physiolo0.88512022
96MP0001929_abnormal_gametogenesis0.88156615
97MP0009379_abnormal_foot_pigmentation0.88103132
98MP0002653_abnormal_ependyma_morphology0.87704779
99MP0008058_abnormal_DNA_repair0.86440600
100MP0000383_abnormal_hair_follicle0.84590680
101MP0002876_abnormal_thyroid_physiology0.84542580
102MP0005389_reproductive_system_phenotype0.84472034
103MP0003252_abnormal_bile_duct0.83258940
104MP0001324_abnormal_eye_pigmentation0.83104115
105MP0002229_neurodegeneration0.83077713
106MP0002095_abnormal_skin_pigmentation0.82449521
107MP0002882_abnormal_neuron_morphology0.82297328
108MP0008260_abnormal_autophagy0.81711114
109MP0000678_abnormal_parathyroid_gland0.81004831
110* MP0002064_seizures0.80927627
111MP0005409_darkened_coat_color0.76402848
112MP0003633_abnormal_nervous_system0.76079580
113MP0001293_anophthalmia0.75516298
114MP0002736_abnormal_nociception_after0.75226502
115MP0001756_abnormal_urination0.74432035
116MP0005195_abnormal_posterior_eye0.73727258
117MP0005367_renal/urinary_system_phenotyp0.73709001
118MP0000516_abnormal_urinary_system0.73709001
119MP0005248_abnormal_Harderian_gland0.73090427
120MP0002177_abnormal_outer_ear0.70231480
121MP0001270_distended_abdomen0.69137694
122MP0008569_lethality_at_weaning0.68456102
123MP0001986_abnormal_taste_sensitivity0.68156706
124MP0002277_abnormal_respiratory_mucosa0.68052678
125MP0001286_abnormal_eye_development0.66318505
126MP0000026_abnormal_inner_ear0.65721252
127MP0010030_abnormal_orbit_morphology0.65025393
128MP0005377_hearing/vestibular/ear_phenot0.63675651
129MP0003878_abnormal_ear_physiology0.63675651
130MP0008877_abnormal_DNA_methylation0.63140071
131MP0001963_abnormal_hearing_physiology0.61975615
132MP0000955_abnormal_spinal_cord0.60343921
133MP0002152_abnormal_brain_morphology0.60276262
134MP0001340_abnormal_eyelid_morphology0.60268143
135MP0005503_abnormal_tendon_morphology0.60198605
136MP0001486_abnormal_startle_reflex0.59970515

Predicted human phenotypes

RankGene SetZ-score
1Orthostatic hypotension (HP:0001278)6.90005375
2Neonatal hypoglycemia (HP:0001998)6.59964352
3Abnormal autonomic nervous system physiology (HP:0012332)5.44524745
4Molar tooth sign on MRI (HP:0002419)4.07068125
5Abnormality of midbrain morphology (HP:0002418)4.07068125
6Impulsivity (HP:0100710)3.95882440
7Pendular nystagmus (HP:0012043)3.89003395
8Recurrent corneal erosions (HP:0000495)3.75492805
9Absent rod-and cone-mediated responses on ERG (HP:0007688)3.58588031
10Septo-optic dysplasia (HP:0100842)3.57108720
11Type II lissencephaly (HP:0007260)3.41409430
12Abnormality of the renal medulla (HP:0100957)3.38671700
13Limb dystonia (HP:0002451)3.31805618
14Abnormal rod and cone electroretinograms (HP:0008323)3.24961838
15Abnormality of the renal cortex (HP:0011035)3.17419270
16Exotropia (HP:0000577)3.15834528
17Myokymia (HP:0002411)3.15783747
18Dyschromatopsia (HP:0007641)3.11038029
19Chronic hepatic failure (HP:0100626)3.06578111
20Arthropathy (HP:0003040)3.05156331
21Pancreatic fibrosis (HP:0100732)2.99422312
22Tubular atrophy (HP:0000092)2.90981796
23Hypotension (HP:0002615)2.84742933
24Decreased central vision (HP:0007663)2.81035364
25Cystic liver disease (HP:0006706)2.77233585
26Bony spicule pigmentary retinopathy (HP:0007737)2.73411832
27Amblyopia (HP:0000646)2.73142347
28Chorioretinal atrophy (HP:0000533)2.71363635
29Abolished electroretinogram (ERG) (HP:0000550)2.70794524
30Congenital stationary night blindness (HP:0007642)2.65809375
31Hyperventilation (HP:0002883)2.64211378
32Parakeratosis (HP:0001036)2.55222514
33Lissencephaly (HP:0001339)2.53393032
34Bile duct proliferation (HP:0001408)2.51634868
35Abnormal biliary tract physiology (HP:0012439)2.51634868
36Febrile seizures (HP:0002373)2.50875582
37Pigmentary retinal degeneration (HP:0001146)2.50485219
38Polydipsia (HP:0001959)2.49789793
39Abnormal drinking behavior (HP:0030082)2.49789793
40Sclerocornea (HP:0000647)2.48987848
41Cerebellar dysplasia (HP:0007033)2.48955169
42Severe visual impairment (HP:0001141)2.48413426
43Abnormality of the septum pellucidum (HP:0007375)2.48115424
44Absent/shortened dynein arms (HP:0200106)2.47602785
45Dynein arm defect of respiratory motile cilia (HP:0012255)2.47602785
46Aplasia/Hypoplasia of the tibia (HP:0005772)2.47159890
47Pancreatic cysts (HP:0001737)2.44465238
48Absent septum pellucidum (HP:0001331)2.41679866
49Retinal dysplasia (HP:0007973)2.37119219
50Chromosomal breakage induced by crosslinking agents (HP:0003221)2.36379410
51Attenuation of retinal blood vessels (HP:0007843)2.34547355
52Inability to walk (HP:0002540)2.34387131
53Bilateral microphthalmos (HP:0007633)2.29368361
54Abnormality of dental color (HP:0011073)2.27994164
55Progressive cerebellar ataxia (HP:0002073)2.27817809
56Autoamputation (HP:0001218)2.26324540
57True hermaphroditism (HP:0010459)2.25198566
58Central scotoma (HP:0000603)2.25095749
59Congenital, generalized hypertrichosis (HP:0004540)2.23235703
60Anhidrosis (HP:0000970)2.22727125
61Aplasia/Hypoplasia of the macula (HP:0008059)2.21899016
62Short tibia (HP:0005736)2.20685016
63Intestinal atresia (HP:0011100)2.19818216
64Congenital hepatic fibrosis (HP:0002612)2.19695554
65Gaze-evoked nystagmus (HP:0000640)2.16857287
66Abnormal ciliary motility (HP:0012262)2.16195343
67Optic nerve hypoplasia (HP:0000609)2.15690668
68Male pseudohermaphroditism (HP:0000037)2.15562869
69Decreased circulating renin level (HP:0003351)2.12201925
70Renal cortical cysts (HP:0000803)2.11272458
71Large for gestational age (HP:0001520)2.10155541
72Chromsome breakage (HP:0040012)2.09847629
73Photophobia (HP:0000613)2.08584989
74Polyuria (HP:0000103)2.07422155
75Vaginal atresia (HP:0000148)2.06589899
76Anterior segment dysgenesis (HP:0007700)2.06220116
77Concave nail (HP:0001598)2.05564880
78Abnormality of the renal collecting system (HP:0004742)2.05023367
79Nephrogenic diabetes insipidus (HP:0009806)2.04347454
80Pachygyria (HP:0001302)2.02358651
81Hypothermia (HP:0002045)12.0877081
82Abnormality of alanine metabolism (HP:0010916)1.99841414
83Hyperalaninemia (HP:0003348)1.99841414
84Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99841414
85Abnormality of the labia minora (HP:0012880)1.98092903
86Partial agenesis of the corpus callosum (HP:0001338)1.97554806
87Acute necrotizing encephalopathy (HP:0006965)1.97341172
88External ophthalmoplegia (HP:0000544)1.96057723
89Rib fusion (HP:0000902)1.95309441
90Furrowed tongue (HP:0000221)1.95205527
91Thyroid-stimulating hormone excess (HP:0002925)1.95061276
92Anophthalmia (HP:0000528)1.94898977
93Decreased electroretinogram (ERG) amplitude (HP:0000654)1.93655250
94Aplasia/Hypoplasia of the lens (HP:0008063)1.92095563
95Aplasia/Hypoplasia of the spleen (HP:0010451)1.91919841
96Abnormal respiratory epithelium morphology (HP:0012253)1.91034660
97Abnormal respiratory motile cilium morphology (HP:0005938)1.91034660
98Disproportionate short-trunk short stature (HP:0003521)1.89933316
99Mitochondrial inheritance (HP:0001427)1.89332215
1003-Methylglutaconic aciduria (HP:0003535)1.89323521
101Abnormality of calcium-phosphate metabolism (HP:0100530)1.85836970
102Focal seizures (HP:0007359)1.85326157
103Broad-based gait (HP:0002136)1.85156983
104Congenital sensorineural hearing impairment (HP:0008527)1.84825041
105Acute encephalopathy (HP:0006846)1.84666695
106Osteomalacia (HP:0002749)1.84295682
107Hemiparesis (HP:0001269)1.83599871
108Renal dysplasia (HP:0000110)1.82913019
109Medial flaring of the eyebrow (HP:0010747)1.82883050
110Type II diabetes mellitus (HP:0005978)1.80936050
111Genetic anticipation (HP:0003743)1.80601232
112Increased CSF lactate (HP:0002490)1.80415122
113Lip pit (HP:0100267)1.79617622
114Severe muscular hypotonia (HP:0006829)1.79525039
115Focal motor seizures (HP:0011153)1.78861621
116Progressive inability to walk (HP:0002505)1.78320213
117Limb hypertonia (HP:0002509)1.78048270
118Retinitis pigmentosa (HP:0000510)1.78030082
119Gait imbalance (HP:0002141)1.76855772
120Aplasia/Hypoplasia of the tongue (HP:0010295)1.76310416
121Patellar aplasia (HP:0006443)1.76024390
122Abnormality of the fovea (HP:0000493)1.75489254
123Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74036552
124Congenital primary aphakia (HP:0007707)1.73523649
125Abnormal respiratory motile cilium physiology (HP:0012261)1.71242813
126Preaxial hand polydactyly (HP:0001177)1.70712595
127Aplasia/Hypoplasia affecting the retina (HP:0008061)1.70663335
128Keratoconus (HP:0000563)1.69362215
129Increased corneal curvature (HP:0100692)1.69362215
130Genital tract atresia (HP:0001827)1.69323096
131Oligohydramnios (HP:0001562)1.67903367
132Scotoma (HP:0000575)1.67633048
133Hypoventilation (HP:0002791)1.67381297
134Hypoplasia of the fovea (HP:0007750)1.66352973
135Aplasia/Hypoplasia of the fovea (HP:0008060)1.66352973
136Vitreoretinal degeneration (HP:0000655)1.66020982
137Aganglionic megacolon (HP:0002251)1.65384082
138Corneal erosion (HP:0200020)1.65310089
139Hyperthyroidism (HP:0000836)1.65168462
140Nephronophthisis (HP:0000090)1.64863581
141Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.63785603
142Anencephaly (HP:0002323)1.62935372
143Renal Fanconi syndrome (HP:0001994)1.62918861
144Aplastic anemia (HP:0001915)1.62556146
145Supernumerary spleens (HP:0009799)1.61410922
146Metaphyseal dysplasia (HP:0100255)1.61170337
147Absent eyebrow (HP:0002223)1.60394718
148Abnormality of macular pigmentation (HP:0008002)1.60011127
149Postaxial foot polydactyly (HP:0001830)1.59156285
150Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.58261864
151Occipital encephalocele (HP:0002085)1.56628582
152Optic disc pallor (HP:0000543)1.56217192
153Posterior subcapsular cataract (HP:0007787)1.55646918
154Abnormal number of incisors (HP:0011064)1.55466580
155Constricted visual fields (HP:0001133)1.54857861

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.71487112
2GRK74.62200402
3NTRK13.68403105
4SIK33.67079967
5INSRR3.35392452
6MAP4K23.15362103
7CASK3.14748842
8NTRK32.91584892
9ADRBK22.74389193
10WNK42.27950979
11MATK2.24173891
12ZAK2.14723490
13ACVR1B2.06485951
14GRK52.06169953
15MAP2K72.02306417
16PRPF4B1.93825340
17STK161.92391268
18TAOK31.91268335
19ADRBK11.84785944
20TSSK61.82932193
21AKT31.82340456
22BRD41.80566937
23PLK41.79338311
24OXSR11.78243951
25TNIK1.60519116
26MAP3K41.57279338
27MAP3K121.54537999
28STK391.53926181
29MARK11.52265211
30BMPR1B1.50954310
31TRIM281.46046671
32YES11.45763506
33DAPK21.34058662
34BCKDK1.30544148
35MAPK131.27806019
36DYRK21.24422921
37SIK21.22698195
38NTRK21.21990001
39PAK31.20047383
40SGK21.15503508
41SRPK11.15031468
42SGK2231.12174066
43SGK4941.12174066
44CSNK1G31.11707032
45PRKCE1.09660329
46BMPR21.06004979
47VRK21.05302317
48IRAK21.02314748
49TXK0.98898920
50MAPK150.95657087
51GRK10.94231496
52CDK30.90721101
53BRAF0.90625205
54CDK190.90348047
55TAF10.90331905
56ERBB20.88125320
57TAOK20.87302635
58MKNK20.86430367
59PLK30.86207593
60MAP2K40.85132067
61CAMKK20.83688045
62ERBB30.83096633
63MUSK0.82939072
64MAP2K20.77974364
65MAP3K60.77385116
66EIF2AK20.77305419
67TGFBR10.75479968
68BUB10.75284348
69CSNK1G20.73833024
70MAP3K140.73380023
71PHKG20.70786222
72PHKG10.70786222
73CDK80.70747972
74MINK10.69612641
75MAP2K10.68666693
76STK110.68155835
77MST40.67909746
78IRAK30.65467118
79PNCK0.64880245
80FGFR20.64642269
81VRK10.64125189
82TLK10.62927492
83CSNK1A1L0.62319450
84PASK0.61466543
85PKN10.61309177
86CAMK2A0.60210837
87PTK2B0.59151830
88EPHA30.58306723
89PRKCG0.58233684
90NUAK10.54509716
91TIE10.54112996
92NEK20.54041737
93PIK3CA0.53633589
94CSNK1G10.52540602
95RPS6KA50.51524485
96BCR0.50898997
97EPHB20.50042296
98RPS6KA20.49730035
99MKNK10.49405495
100PINK10.49090865
101MAPKAPK50.49035150
102PLK20.48600518
103DYRK30.47697603
104PRKCZ0.47147901
105PRKCI0.45778000
106MARK30.45170078
107CAMK10.44842323
108UHMK10.44364162
109CSNK1A10.44150507
110CSNK1E0.43458362
111NME20.43332614
112ITK0.42875204
113STK240.42510147
114CDK70.42394348
115EPHA20.42320857
116AURKA0.41869964
117CSNK1D0.41485650
118MAP2K60.40958851
119TTK0.40939725
120NLK0.39974512
121ICK0.39534949
122PRKCQ0.38606728
123PRKAA10.38187764
124WNK30.37206079
125MAP3K20.36603289
126TNK20.35997412
127EIF2AK30.35963361
128PRKG10.35838294
129PRKCB0.35526731
130PRKCA0.35049878
131PBK0.34689821
132PRKACA0.33492853
133MAPK80.33231486
134NME10.33202667
135EPHA40.33027034
136BLK0.32906645
137CDC70.32785562
138STK30.32777589
139CHUK0.32560201
140ATR0.32560084
141PRKACB0.32303430
142FER0.31927937
143LIMK10.31386588
144DYRK1A0.30660334
145STK38L0.30425613
146OBSCN0.29321490

Predicted pathways (KEGG)

RankGene SetZ-score
1Tyrosine metabolism_Homo sapiens_hsa003504.09675150
2Phenylalanine metabolism_Homo sapiens_hsa003603.64449679
3Phototransduction_Homo sapiens_hsa047443.62399113
4Proteasome_Homo sapiens_hsa030503.00857800
5Synaptic vesicle cycle_Homo sapiens_hsa047212.50937724
6Cocaine addiction_Homo sapiens_hsa050302.47734100
7Serotonergic synapse_Homo sapiens_hsa047262.40478578
8Histidine metabolism_Homo sapiens_hsa003402.39312190
9Butanoate metabolism_Homo sapiens_hsa006502.29249833
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.28316724
11Nitrogen metabolism_Homo sapiens_hsa009102.24271542
12* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.19286004
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.16711448
14Ribosome_Homo sapiens_hsa030102.06768162
15Collecting duct acid secretion_Homo sapiens_hsa049662.03158183
16Taste transduction_Homo sapiens_hsa047421.98663129
17* Cholinergic synapse_Homo sapiens_hsa047251.94421171
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.91569226
19Oxidative phosphorylation_Homo sapiens_hsa001901.82212861
20Amphetamine addiction_Homo sapiens_hsa050311.82066360
21Selenocompound metabolism_Homo sapiens_hsa004501.79062815
22Nicotine addiction_Homo sapiens_hsa050331.75145573
23Dopaminergic synapse_Homo sapiens_hsa047281.69648662
24SNARE interactions in vesicular transport_Homo sapiens_hsa041301.65556310
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.62065749
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.60047101
27Olfactory transduction_Homo sapiens_hsa047401.55637456
28Propanoate metabolism_Homo sapiens_hsa006401.50830141
29RNA polymerase_Homo sapiens_hsa030201.50495843
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42575435
31Caffeine metabolism_Homo sapiens_hsa002321.34895217
32Cardiac muscle contraction_Homo sapiens_hsa042601.33420383
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.33119587
34Parkinsons disease_Homo sapiens_hsa050121.31768491
35Insulin secretion_Homo sapiens_hsa049111.29703860
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.26007900
37Circadian entrainment_Homo sapiens_hsa047131.24750326
38Vibrio cholerae infection_Homo sapiens_hsa051101.24712167
39Huntingtons disease_Homo sapiens_hsa050161.24496324
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.22248236
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14521609
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.14005458
43Chemical carcinogenesis_Homo sapiens_hsa052041.12712885
44Protein export_Homo sapiens_hsa030601.12328987
45Glutamatergic synapse_Homo sapiens_hsa047241.11980281
46Basal transcription factors_Homo sapiens_hsa030221.09637342
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.09025624
48Peroxisome_Homo sapiens_hsa041461.08350604
49Retinol metabolism_Homo sapiens_hsa008301.08173439
50Alzheimers disease_Homo sapiens_hsa050101.07221804
51Morphine addiction_Homo sapiens_hsa050321.03632951
52Intestinal immune network for IgA production_Homo sapiens_hsa046721.00713772
53Fat digestion and absorption_Homo sapiens_hsa049751.00249911
54ABC transporters_Homo sapiens_hsa020100.98375357
55Alcoholism_Homo sapiens_hsa050340.98342182
56Sphingolipid metabolism_Homo sapiens_hsa006000.98068837
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95347881
58Calcium signaling pathway_Homo sapiens_hsa040200.94856515
59Fanconi anemia pathway_Homo sapiens_hsa034600.91555866
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91284343
61Spliceosome_Homo sapiens_hsa030400.89792835
62One carbon pool by folate_Homo sapiens_hsa006700.89100085
63Axon guidance_Homo sapiens_hsa043600.87880756
64Rheumatoid arthritis_Homo sapiens_hsa053230.86858032
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.86611597
66beta-Alanine metabolism_Homo sapiens_hsa004100.86097094
67Purine metabolism_Homo sapiens_hsa002300.86028061
68Phagosome_Homo sapiens_hsa041450.85043861
69Renin secretion_Homo sapiens_hsa049240.84281953
70Autoimmune thyroid disease_Homo sapiens_hsa053200.83835511
71Arginine and proline metabolism_Homo sapiens_hsa003300.83695865
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79818758
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77762196
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76522034
75Regulation of autophagy_Homo sapiens_hsa041400.75059840
76Mineral absorption_Homo sapiens_hsa049780.74585155
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74199404
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73581447
79Tryptophan metabolism_Homo sapiens_hsa003800.73426146
80Long-term depression_Homo sapiens_hsa047300.73334849
81Wnt signaling pathway_Homo sapiens_hsa043100.72130971
82mRNA surveillance pathway_Homo sapiens_hsa030150.70887071
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70532652
84Linoleic acid metabolism_Homo sapiens_hsa005910.69909244
85Mismatch repair_Homo sapiens_hsa034300.69376483
86Homologous recombination_Homo sapiens_hsa034400.69367684
87African trypanosomiasis_Homo sapiens_hsa051430.68580300
88Glycerolipid metabolism_Homo sapiens_hsa005610.66213410
89Metabolic pathways_Homo sapiens_hsa011000.64831406
90Arachidonic acid metabolism_Homo sapiens_hsa005900.64637669
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64577111
92RNA degradation_Homo sapiens_hsa030180.63792051
93GABAergic synapse_Homo sapiens_hsa047270.63285627
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62577589
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60902308
96Basal cell carcinoma_Homo sapiens_hsa052170.60769072
97GnRH signaling pathway_Homo sapiens_hsa049120.60221293
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57831906
99Primary immunodeficiency_Homo sapiens_hsa053400.57498968
100Pyrimidine metabolism_Homo sapiens_hsa002400.57142746
101Pancreatic secretion_Homo sapiens_hsa049720.56280495
102Fatty acid degradation_Homo sapiens_hsa000710.54533049
103Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53073935
104Circadian rhythm_Homo sapiens_hsa047100.51821892
105Asthma_Homo sapiens_hsa053100.51317110
106Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.50326629
107Hedgehog signaling pathway_Homo sapiens_hsa043400.50015473
108Steroid biosynthesis_Homo sapiens_hsa001000.49229156
109Notch signaling pathway_Homo sapiens_hsa043300.49209571
110Ovarian steroidogenesis_Homo sapiens_hsa049130.48294931
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47450802
112Cyanoamino acid metabolism_Homo sapiens_hsa004600.47046252
113Nucleotide excision repair_Homo sapiens_hsa034200.46717680
114Melanogenesis_Homo sapiens_hsa049160.44572344
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44362860
116Type I diabetes mellitus_Homo sapiens_hsa049400.43189023
117cAMP signaling pathway_Homo sapiens_hsa040240.42127999
118Sulfur metabolism_Homo sapiens_hsa009200.42076974
119Base excision repair_Homo sapiens_hsa034100.41805109
120Salivary secretion_Homo sapiens_hsa049700.41463596
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.40767601
122Non-homologous end-joining_Homo sapiens_hsa034500.39855345
123Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39812052
124Sulfur relay system_Homo sapiens_hsa041220.39690397
125Melanoma_Homo sapiens_hsa052180.39026627
126Gap junction_Homo sapiens_hsa045400.38270332
127Prolactin signaling pathway_Homo sapiens_hsa049170.37313332
128Ether lipid metabolism_Homo sapiens_hsa005650.37066690
129Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36819351
130Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36732002
131Fatty acid metabolism_Homo sapiens_hsa012120.36708879
132Fatty acid biosynthesis_Homo sapiens_hsa000610.36021848
133Epstein-Barr virus infection_Homo sapiens_hsa051690.34825763
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34062438
135Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33920046
136Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33060585
137Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32220761
138Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31825753
139Other glycan degradation_Homo sapiens_hsa005110.31500737
140Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30664231
141Vascular smooth muscle contraction_Homo sapiens_hsa042700.29622489
142Long-term potentiation_Homo sapiens_hsa047200.29259463
143Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28190507

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