ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	musculoskeletal movement (GO:0050881)	9.60309443
2	multicellular organismal movement (GO:0050879)	9.60309443
3	myotube cell development (GO:0014904)	9.25845046
4	myoblast fusion (GO:0007520)	9.17319048
5	muscle cell fate commitment (GO:0042693)	8.69639624
6	syncytium formation by plasma membrane fusion (GO:0000768)	8.32106155
7	lens development in camera-type eye (GO:0002088)	8.29202403
8	syncytium formation (GO:0006949)	8.01220412
9	positive regulation of myotube differentiation (GO:0010831)	7.84838741
10	actin filament-based movement (GO:0030048)	7.84339981
11	plasma membrane repair (GO:0001778)	7.54802072
12	sarcoplasmic reticulum calcium ion transport (GO:0070296)	7.27463036
13	muscle cell cellular homeostasis (GO:0046716)	7.06737151
14	positive regulation of skeletal muscle tissue development (GO:0048643)	6.75953931
15	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	6.51694028
16	regulation of syncytium formation by plasma membrane fusion (GO:0060142)	6.43961856
17	response to inactivity (GO:0014854)	6.24968596
18	skeletal muscle tissue development (GO:0007519)	6.14678734
19	lens fiber cell development (GO:0070307)	6.03210906
20	regulation of skeletal muscle contraction (GO:0014819)	5.98140266
21	sarcomere organization (GO:0045214)	5.87785397
22	response to muscle activity (GO:0014850)	5.85750737
23	muscle fiber development (GO:0048747)	5.83534846
24	plasma membrane fusion (GO:0045026)	5.77959635
25	response to stimulus involved in regulation of muscle adaptation (GO:0014874)	5.64703831
26	striated muscle atrophy (GO:0014891)	5.54183402
27	regulation of relaxation of muscle (GO:1901077)	5.53554004
28	muscle organ development (GO:0007517)	5.45147871
29	striated muscle contraction (GO:0006941)	5.38667270
30	muscle structure development (GO:0061061)	5.30227512
31	lens fiber cell differentiation (GO:0070306)	5.21858031
32	positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)	5.20762885
33	regulation of skeletal muscle cell differentiation (GO:2001014)	5.18520235
34	negative regulation of potassium ion transmembrane transport (GO:1901380)	5.15669685
35	negative regulation of cell size (GO:0045792)	4.84913295
36	* muscle contraction (GO:0006936)	4.75506550
37	positive regulation of myoblast differentiation (GO:0045663)	4.73963413
38	myofibril assembly (GO:0030239)	4.72498429
39	muscle atrophy (GO:0014889)	4.71507183
40	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	4.60917910
41	striated muscle cell development (GO:0055002)	4.52291978
42	actomyosin structure organization (GO:0031032)	4.34610965
43	endodermal cell differentiation (GO:0035987)	4.28375396
44	* muscle system process (GO:0003012)	4.22297802
45	heterotypic cell-cell adhesion (GO:0034113)	4.20566585
46	neuromuscular synaptic transmission (GO:0007274)	4.17965618
47	striated muscle tissue development (GO:0014706)	4.16025813
48	regulation of myotube differentiation (GO:0010830)	4.13301721
49	creatine metabolic process (GO:0006600)	4.09126133
50	negative regulation of protein localization to cell surface (GO:2000009)	4.07655775
51	regulation of myoblast differentiation (GO:0045661)	4.06090395
52	muscle cell development (GO:0055001)	4.01188972
53	myotube differentiation (GO:0014902)	3.95541231
54	muscle adaptation (GO:0043500)	3.86713594
55	neuromuscular junction development (GO:0007528)	3.80766446
56	lens morphogenesis in camera-type eye (GO:0002089)	3.72871011
57	muscle tissue development (GO:0060537)	3.70670615
58	embryonic camera-type eye development (GO:0031076)	3.68954308
59	regulation of striated muscle contraction (GO:0006942)	3.63733731
60	regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)	3.52878455
61	positive regulation of striated muscle cell differentiation (GO:0051155)	3.50951965
62	response to lithium ion (GO:0010226)	3.47859125
63	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	3.47809668
64	regulation of p38MAPK cascade (GO:1900744)	3.46312572
65	cellular response to estradiol stimulus (GO:0071392)	3.39965854
66	muscle tissue morphogenesis (GO:0060415)	3.37337530
67	positive regulation of muscle cell differentiation (GO:0051149)	3.35448671
68	regulation of actin filament-based movement (GO:1903115)	3.33681788
69	response to activity (GO:0014823)	3.31351232
70	cardiac muscle hypertrophy (GO:0003300)	3.30867411
71	regulation of skeletal muscle fiber development (GO:0048742)	3.29203554
72	regulation of muscle system process (GO:0090257)	3.27397939
73	glycogen biosynthetic process (GO:0005978)	3.25875218
74	glucan biosynthetic process (GO:0009250)	3.25875218
75	striated muscle adaptation (GO:0014888)	3.20901448
76	positive regulation of astrocyte differentiation (GO:0048711)	3.17966687
77	regulation of skeletal muscle tissue development (GO:0048641)	3.17621061
78	glycogen catabolic process (GO:0005980)	3.15826026
79	response to caffeine (GO:0031000)	3.15115575
80	skeletal muscle tissue regeneration (GO:0043403)	3.14038738
81	striated muscle hypertrophy (GO:0014897)	3.13183604
82	cardiac myofibril assembly (GO:0055003)	3.12443356
83	face morphogenesis (GO:0060325)	3.10389479
84	regulation of muscle contraction (GO:0006937)	3.06098491
85	regulation of calcium ion transmembrane transporter activity (GO:1901019)	3.05398975
86	regulation of calcium ion transmembrane transport (GO:1903169)	3.05398975
87	regulation of sarcomere organization (GO:0060297)	3.02589656
88	positive regulation of calcium ion transmembrane transporter activity (GO:1901021)	2.98254319
89	postsynaptic membrane organization (GO:0001941)	2.96876351
90	myelin assembly (GO:0032288)	2.96081270
91	mRNA transcription from RNA polymerase II promoter (GO:0042789)	2.95000706
92	glucan catabolic process (GO:0009251)	2.93704785
93	cardiac muscle tissue morphogenesis (GO:0055008)	2.92523975
94	regulation of cell communication by electrical coupling (GO:0010649)	2.91998073
95	synaptic transmission, cholinergic (GO:0007271)	2.90148735
96	skeletal muscle cell differentiation (GO:0035914)	2.89352409
97	regulation of muscle cell differentiation (GO:0051147)	2.87888961
98	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	2.83291534
99	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	2.82163138
100	embryonic retina morphogenesis in camera-type eye (GO:0060059)	2.79706769
101	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	2.79613834
102	skeletal muscle adaptation (GO:0043501)	2.79226621
103	regulation of striated muscle cell differentiation (GO:0051153)	2.79192451
104	basement membrane organization (GO:0071711)	2.78736904
105	cardiac muscle contraction (GO:0060048)	2.77476474
106	glycoprotein catabolic process (GO:0006516)	2.76633395
107	muscle hypertrophy (GO:0014896)	2.75648286
108	positive regulation of p38MAPK cascade (GO:1900745)	2.75234599
109	epithelial cell-cell adhesion (GO:0090136)	2.75092710
110	muscle organ morphogenesis (GO:0048644)	2.74261589
111	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	2.71901704
112	membrane tubulation (GO:0097320)	2.69842905
113	cellular polysaccharide catabolic process (GO:0044247)	2.69778985
114	mRNA transcription (GO:0009299)	2.68214347
115	response to parathyroid hormone (GO:0071107)	2.65231081
116	camera-type eye development (GO:0043010)	2.63206263
117	cardiac muscle cell development (GO:0055013)	2.57944834
118	cellular response to osmotic stress (GO:0071470)	2.53155808
119	regulation of membrane repolarization (GO:0060306)	2.52031272
120	positive regulation of protein depolymerization (GO:1901881)	2.51009622
121	cardiac cell development (GO:0055006)	2.50805263
122	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	2.50546634
123	collagen fibril organization (GO:0030199)	2.48278249
124	muscle filament sliding (GO:0030049)	12.1797144
125	actin-myosin filament sliding (GO:0033275)	12.1797144
126	skeletal muscle fiber development (GO:0048741)	11.1087877
127	skeletal muscle contraction (GO:0003009)	10.7760125
128	actin-mediated cell contraction (GO:0070252)	10.1322137

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TP63_17297297_ChIP-ChIP_HaCaT_Human	3.75515844
2	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	3.75015131
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.56059857
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.50747565
5	RARG_19884340_ChIP-ChIP_MEFs_Mouse	3.32549105
6	ESR1_20079471_ChIP-ChIP_T-47D_Human	3.29122871
7	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.05119757
8	VDR_21846776_ChIP-Seq_THP-1_Human	3.02838381
9	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.99447219
10	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.94917230
11	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.72228447
12	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	2.69188254
13	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.65533298
14	GATA1_22025678_ChIP-Seq_K562_Human	2.62366147
15	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	2.58422153
16	ZFP281_18757296_ChIP-ChIP_E14_Mouse	2.35076239
17	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.11587765
18	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.06855230
19	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	2.04063404
20	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	2.03934697
21	P68_20966046_ChIP-Seq_HELA_Human	2.01138374
22	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	2.00707456
23	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.98186481
24	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.97438289
25	CLOCK_20551151_ChIP-Seq_293T_Human	1.91082190
26	LXR_22292898_ChIP-Seq_THP-1_Human	1.90117723
27	E2F1_20622854_ChIP-Seq_HELA_Human	1.87246585
28	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.81534210
29	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.81061587
30	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.75322371
31	* MAF_26560356_Chip-Seq_TH2_Human	1.75290835
32	TBX20_22328084_ChIP-Seq_HEART_Mouse	1.73699649
33	TBX20_22080862_ChIP-Seq_HEART_Mouse	1.73699649
34	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.68821826
35	SMC1_22415368_ChIP-Seq_MEFs_Mouse	1.67460701
36	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.65403252
37	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.64797480
38	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.63390149
39	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.61917618
40	MAF_26560356_Chip-Seq_TH1_Human	1.60860877
41	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.59564019
42	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.59502810
43	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.59306032
44	CJUN_26792858_Chip-Seq_BT549_Human	1.59012672
45	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.58133730
46	ATF3_27146783_Chip-Seq_COLON_Human	1.57947977
47	TP53_22127205_ChIP-Seq_IMR90_Human	1.56383288
48	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.55254574
49	SMC3_22415368_ChIP-Seq_MEFs_Mouse	1.54782711
50	* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.53887158
51	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.52474504
52	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	1.51181352
53	DROSHA_22980978_ChIP-Seq_HELA_Human	1.50617274
54	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.50351699
55	EZH2_22144423_ChIP-Seq_EOC_Human	1.49849221
56	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	1.49609687
57	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.48468669
58	SMC4_20622854_ChIP-Seq_HELA_Human	1.47927631
59	KDM2B_26808549_Chip-Seq_DND41_Human	1.47345482
60	BCL6_27268052_Chip-Seq_Bcells_Human	1.45879022
61	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.41803369
62	* TET1_21451524_ChIP-Seq_MESCs_Mouse	1.41737946
63	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.41344189
64	RACK7_27058665_Chip-Seq_MCF-7_Human	1.40065039
65	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.39442436
66	VDR_24763502_ChIP-Seq_THP-1_Human	1.39211133
67	KDM2B_26808549_Chip-Seq_K562_Human	1.38099259
68	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.32951938
69	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.31008861
70	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.30914649
71	BCOR_27268052_Chip-Seq_Bcells_Human	1.30747727
72	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.30600014
73	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.30463993
74	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.28810834
75	* RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.28750572
76	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.28389526
77	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.27198196
78	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.25475701
79	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.24773401
80	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.24773401
81	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.24297673
82	CTCF_27219007_Chip-Seq_Bcells_Human	1.23399121
83	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.23090151
84	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.22994722
85	* CTCF_21964334_Chip-Seq_Bcells_Human	1.21023671
86	CREB1_26743006_Chip-Seq_LNCaP_Human	1.20616384
87	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.20301726
88	TCF7_22412390_ChIP-Seq_EML_Mouse	1.20269921
89	PHF8_20622854_ChIP-Seq_HELA_Human	1.20131669
90	* OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.19695919
91	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.19141819
92	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.18740103
93	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.17129393
94	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.15402836
95	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.15264545
96	* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.15174340
97	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.14871876
98	DMRT1_23473982_ChIP-Seq_TESTES_Mouse	1.14781926
99	MYC_22102868_ChIP-Seq_BL_Human	1.14399272
100	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.13299949
101	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.12951015
102	MYC_27129775_Chip-Seq_CORNEA_Mouse	1.12279118
103	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.12267358
104	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.09946052
105	GATA4_21415370_ChIP-Seq_HL-1_Mouse	1.09761471
106	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.08656473
107	OCT4_20526341_ChIP-Seq_ESCs_Human	1.08583274
108	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.08238301
109	UTX_26944678_Chip-Seq_JUKART_Human	1.07775054
110	GATA1_19941827_ChIP-Seq_MEL86_Mouse	1.07622459
111	TP53_18474530_ChIP-ChIP_U2OS_Human	1.06494808
112	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.05968686
113	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.05615970
114	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.04521412
115	TP63_22573176_ChIP-Seq_HFKS_Human	1.04253082
116	* FOXP1_21924763_ChIP-Seq_HESCs_Human	1.03874587
117	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.03397631
118	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.02139067
119	SPI1_20517297_ChIP-Seq_HL60_Human	1.02103433
120	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.02093298
121	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	1.01459820
122	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.00640647
123	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.00487508
124	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.00267223
125	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.00223875
126	CTCF_21964334_ChIP-Seq_BJAB-B_Human	0.99977422
127	* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.99268770
128	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.98492098
129	CTCF_27219007_Chip-Seq_ERYTHROID_Human	0.97393225
130	TP53_16413492_ChIP-PET_HCT116_Human	0.96692975
131	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.96580657
132	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.96438716
133	BRD4_25478319_ChIP-Seq_HGPS_Human	0.95752055
134	SA1_27219007_Chip-Seq_Bcells_Human	0.95615292
135	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.94924867
136	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	0.94732592
137	SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human	0.94724776
138	ZNF263_19887448_ChIP-Seq_K562_Human	0.94567851
139	TP53_23651856_ChIP-Seq_MEFs_Mouse	0.94131703
140	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.93917856
141	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.93172962
142	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.92404080
143	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.92089586
144	POU5F1_16518401_ChIP-PET_MESCs_Mouse	0.91131735
145	UBF1/2_26484160_Chip-Seq_HMECs_Human	0.91017631
146	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.84348227
147	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.84327990
148	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.83463432
149	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.83367017

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000749_muscle_degeneration	7.56016380
2	MP0000751_myopathy	6.64728304
3	MP0000733_abnormal_muscle_development	4.66690329
4	MP0004145_abnormal_muscle_electrophysio	4.45672385
5	MP0000750_abnormal_muscle_regeneration	4.17686835
6	MP0000747_muscle_weakness	3.95098495
7	* MP0002106_abnormal_muscle_physiology	3.51230173
8	MP0004270_analgesia	3.40292828
9	MP0002269_muscular_atrophy	3.37435127
10	* MP0000759_abnormal_skeletal_muscle	3.32642784
11	* MP0004087_abnormal_muscle_fiber	3.29215111
12	MP0002837_dystrophic_cardiac_calcinosis	3.14490271
13	MP0002697_abnormal_eye_size	3.08304293
14	* MP0005369_muscle_phenotype	3.00661585
15	MP0002108_abnormal_muscle_morphology	2.42743759
16	MP0004233_abnormal_muscle_weight	2.42102239
17	MP0002249_abnormal_larynx_morphology	2.26327818
18	MP0004084_abnormal_cardiac_muscle	2.14375312
19	MP0010030_abnormal_orbit_morphology	2.13916756
20	MP0005193_abnormal_anterior_eye	2.08224789
21	MP0005330_cardiomyopathy	1.95558067
22	MP0005171_absent_coat_pigmentation	1.94557277
23	MP0008438_abnormal_cutaneous_collagen	1.93062253
24	MP0005451_abnormal_body_composition	1.90771888
25	MP0001661_extended_life_span	1.86183907
26	MP0003950_abnormal_plasma_membrane	1.78602581
27	MP0002971_abnormal_brown_adipose	1.74171626
28	MP0005623_abnormal_meninges_morphology	1.71636959
29	MP0003941_abnormal_skin_development	1.70474466
30	MP0004036_abnormal_muscle_relaxation	1.66651219
31	MP0001986_abnormal_taste_sensitivity	1.61256939
32	MP0005423_abnormal_somatic_nervous	1.59370901
33	MP0005620_abnormal_muscle_contractility	1.58708041
34	MP0000767_abnormal_smooth_muscle	1.46796063
35	MP0001542_abnormal_bone_strength	1.42823374
36	MP0001346_abnormal_lacrimal_gland	1.42758633
37	MP0001299_abnormal_eye_distance/	1.38928305
38	MP0003279_aneurysm	1.28726909
39	MP0004215_abnormal_myocardial_fiber	1.26118239
40	MP0010630_abnormal_cardiac_muscle	1.25565128
41	MP0005083_abnormal_biliary_tract	1.17510317
42	MP0009250_abnormal_appendicular_skeleto	1.11830488
43	MP0005503_abnormal_tendon_morphology	1.11092277
44	MP0001915_intracranial_hemorrhage	1.10775409
45	MP0003566_abnormal_cell_adhesion	1.09905019
46	MP0004272_abnormal_basement_membrane	1.08490634
47	MP0003646_muscle_fatigue	1.05129086
48	MP0003136_yellow_coat_color	1.04313727
49	MP0003705_abnormal_hypodermis_morpholog	1.03397195
50	MP0005197_abnormal_uvea_morphology	1.02589107
51	MP0002114_abnormal_axial_skeleton	1.02103333
52	MP0002877_abnormal_melanocyte_morpholog	1.01374872
53	MP0003879_abnormal_hair_cell	1.00308353
54	MP0002972_abnormal_cardiac_muscle	0.99249209
55	MP0002234_abnormal_pharynx_morphology	0.98959944
56	MP0003091_abnormal_cell_migration	0.94810468
57	MP0000013_abnormal_adipose_tissue	0.94478903
58	MP0003385_abnormal_body_wall	0.93313225
59	MP0005266_abnormal_metabolism	0.90887529
60	MP0002734_abnormal_mechanical_nocicepti	0.89033518
61	MP0005248_abnormal_Harderian_gland	0.87224542
62	MP0001958_emphysema	0.87074785
63	MP0002127_abnormal_cardiovascular_syste	0.86864390
64	MP0003942_abnormal_urinary_system	0.84425365
65	MP0005409_darkened_coat_color	0.83451602
66	MP0001286_abnormal_eye_development	0.83349347
67	MP0005275_abnormal_skin_tensile	0.79825677
68	MP0005367_renal/urinary_system_phenotyp	0.77975320
69	MP0000516_abnormal_urinary_system	0.77975320
70	MP0005508_abnormal_skeleton_morphology	0.77260037
71	MP0004134_abnormal_chest_morphology	0.75236041
72	MP0003755_abnormal_palate_morphology	0.74965167
73	MP0004197_abnormal_fetal_growth/weight/	0.74647057
74	MP0009384_cardiac_valve_regurgitation	0.73286506
75	MP0006036_abnormal_mitochondrial_physio	0.73112813
76	MP0002932_abnormal_joint_morphology	0.71527592
77	MP0009780_abnormal_chondrocyte_physiolo	0.70619914
78	MP0005257_abnormal_intraocular_pressure	0.70015333
79	MP0005174_abnormal_tail_pigmentation	0.69593288
80	MP0001440_abnormal_grooming_behavior	0.68699535
81	MP0000858_altered_metastatic_potential	0.67584596
82	MP0005375_adipose_tissue_phenotype	0.67047860
83	MP0003115_abnormal_respiratory_system	0.64950611
84	MP0000049_abnormal_middle_ear	0.64929627
85	MP0008569_lethality_at_weaning	0.61850681
86	MP0004185_abnormal_adipocyte_glucose	0.61314622
87	MP0003045_fibrosis	0.60995461
88	MP0005076_abnormal_cell_differentiation	0.60956354
89	MP0002092_abnormal_eye_morphology	0.60731826
90	MP0000762_abnormal_tongue_morphology	0.60390172
91	MP0000003_abnormal_adipose_tissue	0.59163493
92	MP0003221_abnormal_cardiomyocyte_apopto	0.58362845
93	MP0004510_myositis	0.57341629
94	MP0002896_abnormal_bone_mineralization	0.55971229
95	MP0004858_abnormal_nervous_system	0.55460804
96	MP0003137_abnormal_impulse_conducting	0.54443172
97	MP0003283_abnormal_digestive_organ	0.54130617
98	MP0002933_joint_inflammation	0.53243468
99	MP0004484_altered_response_of	0.53063797
100	MP0006138_congestive_heart_failure	0.52181989
101	MP0000428_abnormal_craniofacial_morphol	0.51082650
102	MP0002332_abnormal_exercise_endurance	0.47713116
103	MP0002128_abnormal_blood_circulation	0.47131018
104	MP0002160_abnormal_reproductive_system	0.47090763
105	MP0000266_abnormal_heart_morphology	0.46557470
106	MP0000163_abnormal_cartilage_morphology	0.45451713
107	* MP0001943_abnormal_respiration	0.44504355
108	MP0003828_pulmonary_edema	0.43617927
109	MP0005023_abnormal_wound_healing	0.43302196
110	MP0002638_abnormal_pupillary_reflex	0.42745709
111	MP0001614_abnormal_blood_vessel	0.42439845
112	MP0000534_abnormal_ureter_morphology	0.40704166
113	MP0004130_abnormal_muscle_cell	0.40336036
114	MP0003656_abnormal_erythrocyte_physiolo	0.40210312
115	MP0005501_abnormal_skin_physiology	0.39947050
116	MP0005319_abnormal_enzyme/_coenzyme	0.39878980
117	MP0000432_abnormal_head_morphology	0.38505108
118	MP0004085_abnormal_heartbeat	0.38475851
119	MP0002116_abnormal_craniofacial_bone	0.38040672
120	MP0008775_abnormal_heart_ventricle	0.36712564
121	* MP0002081_perinatal_lethality	0.36612877
122	MP0002113_abnormal_skeleton_development	0.36526561
123	MP0001544_abnormal_cardiovascular_syste	0.36402145
124	MP0005385_cardiovascular_system_phenoty	0.36402145
125	MP0005621_abnormal_cell_physiology	0.36368073
126	MP0003959_abnormal_lean_body	0.35637757
127	MP0002060_abnormal_skin_morphology	0.35041958
128	MP0001756_abnormal_urination	0.33733326
129	MP0008770_decreased_survivor_rate	0.32256479
130	MP0006276_abnormal_autonomic_nervous	0.29740600
131	* MP0003948_abnormal_gas_homeostasis	0.27930600
132	MP0002822_catalepsy	0.27338312
133	MP0002163_abnormal_gland_morphology	0.26798201
134	MP0002089_abnormal_postnatal_growth/wei	0.26401885
135	MP0005584_abnormal_enzyme/coenzyme_acti	0.26013767

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Nemaline bodies (HP:0003798)	8.11335100
2	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	8.06455738
3	* Fetal akinesia sequence (HP:0001989)	7.58363446
4	Muscle fiber inclusion bodies (HP:0100299)	7.45041799
5	Type 1 muscle fiber predominance (HP:0003803)	7.38518124
6	* Popliteal pterygium (HP:0009756)	7.34281010
7	Nuclear cataract (HP:0100018)	7.14535189
8	Type 2 muscle fiber atrophy (HP:0003554)	6.52029365
9	* Abnormality of placental membranes (HP:0011409)	6.31881700
10	* Amniotic constriction ring (HP:0009775)	6.31881700
11	* Aplasia of the musculature (HP:0100854)	6.28393586
12	Distal arthrogryposis (HP:0005684)	5.94957906
13	Zonular cataract (HP:0010920)	5.92984900
14	Muscle fiber atrophy (HP:0100295)	5.92614934
15	Weak cry (HP:0001612)	5.72418970
16	Abnormality of the neuromuscular junction (HP:0003398)	5.71452738
17	Fatigable weakness (HP:0003473)	5.71452738
18	Round ear (HP:0100830)	5.65906340
19	* Malignant hyperthermia (HP:0002047)	5.65853195
20	Ulnar deviation of the wrist (HP:0003049)	5.36619456
21	Myopathic facies (HP:0002058)	4.99940797
22	* Akinesia (HP:0002304)	4.91881245
23	Bulbar palsy (HP:0001283)	4.79177370
24	Calcaneovalgus deformity (HP:0001848)	4.75244448
25	Abnormality of skeletal muscle fiber size (HP:0012084)	4.48884254
26	Gowers sign (HP:0003391)	4.42622872
27	Deformed tarsal bones (HP:0008119)	4.34979257
28	Absent phalangeal crease (HP:0006109)	3.93461936
29	Easy fatigability (HP:0003388)	3.90266177
30	* Thin ribs (HP:0000883)	3.74933156
31	Mildly elevated creatine phosphokinase (HP:0008180)	3.74456798
32	* Pterygium (HP:0001059)	3.72041504
33	Centrally nucleated skeletal muscle fibers (HP:0003687)	3.63659942
34	* Aplasia/Hypoplasia involving the musculature (HP:0001460)	3.60250509
35	Increased variability in muscle fiber diameter (HP:0003557)	3.50826925
36	EMG: myopathic abnormalities (HP:0003458)	3.50494243
37	Hip contracture (HP:0003273)	3.43413370
38	Slender build (HP:0001533)	3.42097523
39	Generalized muscle weakness (HP:0003324)	3.41417113
40	Abnormal finger flexion creases (HP:0006143)	3.35221334
41	Difficulty climbing stairs (HP:0003551)	3.30114342
42	Abnormality of the calf musculature (HP:0001430)	3.21022418
43	Scapular winging (HP:0003691)	3.16568746
44	* Hypoplastic heart (HP:0001961)	3.11040837
45	Muscle fiber splitting (HP:0003555)	3.04282542
46	Hyporeflexia of lower limbs (HP:0002600)	3.03221995
47	Trismus (HP:0000211)	3.03185577
48	Difficulty running (HP:0009046)	3.02948776
49	Abnormality of the calcaneus (HP:0008364)	3.01060852
50	Neck muscle weakness (HP:0000467)	2.98710060
51	Abnormality of the left ventricular outflow tract (HP:0011103)	2.97269341
52	Subaortic stenosis (HP:0001682)	2.97269341
53	* Cystic hygroma (HP:0000476)	2.94201986
54	Respiratory insufficiency due to muscle weakness (HP:0002747)	2.86763771
55	Asymmetric septal hypertrophy (HP:0001670)	2.73187045
56	Poor suck (HP:0002033)	2.69867107
57	Increased connective tissue (HP:0009025)	2.69075396
58	Spinal rigidity (HP:0003306)	2.65312827
59	Distal lower limb amyotrophy (HP:0008944)	2.58709612
60	Breech presentation (HP:0001623)	2.57332843
61	Calf muscle hypertrophy (HP:0008981)	2.52416867
62	Frequent falls (HP:0002359)	2.52073149
63	Infantile muscular hypotonia (HP:0008947)	2.51516859
64	Rhabdomyolysis (HP:0003201)	2.50206392
65	Myoglobinuria (HP:0002913)	2.41503274
66	Limited hip movement (HP:0008800)	2.39169817
67	Muscle stiffness (HP:0003552)	2.38493428
68	Areflexia of lower limbs (HP:0002522)	2.34009574
69	* Abnormalities of placenta or umbilical cord (HP:0001194)	2.32089084
70	Exercise-induced myalgia (HP:0003738)	2.27402416
71	* Diminished movement (HP:0002374)	2.24915408
72	Mask-like facies (HP:0000298)	2.24830131
73	EMG: neuropathic changes (HP:0003445)	2.22732005
74	Muscle hypertrophy of the lower extremities (HP:0008968)	2.22386567
75	Chin dimple (HP:0010751)	2.20047583
76	* Arthrogryposis multiplex congenita (HP:0002804)	2.19144689
77	* Webbed neck (HP:0000465)	2.16856424
78	Limb-girdle muscle atrophy (HP:0003797)	2.13194235
79	Metatarsus adductus (HP:0001840)	2.09851009
80	Rimmed vacuoles (HP:0003805)	2.09340592
81	Abnormality of the shoulder girdle musculature (HP:0001435)	2.07692593
82	Nonprogressive disorder (HP:0003680)	1.99506472
83	Lower limb amyotrophy (HP:0007210)	1.98756540
84	Thin bony cortex (HP:0002753)	1.92345122
85	Depressed nasal tip (HP:0000437)	1.90532702
86	Congenital hip dislocation (HP:0001374)	1.86968042
87	Facial diplegia (HP:0001349)	1.86192014
88	Testicular atrophy (HP:0000029)	1.84793017
89	Congenital cataract (HP:0000519)	1.81583693
90	Waddling gait (HP:0002515)	1.81300921
91	Progressive muscle weakness (HP:0003323)	1.80782949
92	Right ventricular cardiomyopathy (HP:0011663)	1.76761301
93	Bundle branch block (HP:0011710)	1.74000530
94	Atrioventricular block (HP:0001678)	1.73618713
95	Knee flexion contracture (HP:0006380)	1.72008407
96	Lipoatrophy (HP:0100578)	1.71474217
97	Heart block (HP:0012722)	1.71456305
98	Proximal amyotrophy (HP:0007126)	1.67419526
99	Abnormal atrioventricular conduction (HP:0005150)	1.65685299
100	Generalized amyotrophy (HP:0003700)	1.64711084
101	Tarsal synostosis (HP:0008368)	1.64515832
102	* Rocker bottom foot (HP:0001838)	1.64068747
103	Hyperkalemia (HP:0002153)	1.63143466
104	Exercise-induced muscle cramps (HP:0003710)	1.63094140
105	Ulnar deviation of finger (HP:0009465)	1.60772572
106	Short palpebral fissure (HP:0012745)	1.59898929
107	* Vertebral fusion (HP:0002948)	1.57382305
108	Dilated cardiomyopathy (HP:0001644)	1.56882977
109	Corneal dystrophy (HP:0001131)	1.51836004
110	Synostosis involving bones of the feet (HP:0009140)	1.50648847
111	Synostosis involving bones of the lower limbs (HP:0009138)	1.50648847
112	Anterior segment dysgenesis (HP:0007700)	1.48903502
113	Myotonia (HP:0002486)	1.46797537
114	Distal lower limb muscle weakness (HP:0009053)	1.45471359
115	Upper limb amyotrophy (HP:0009129)	1.44268629
116	Distal upper limb amyotrophy (HP:0007149)	1.44268629
117	Ulnar deviation of the hand or of fingers of the hand (HP:0001193)	1.42576933
118	Hypoplastic ischia (HP:0003175)	1.41760971
119	Sudden death (HP:0001699)	1.40118036
120	Abnormal auditory evoked potentials (HP:0006958)	1.39257495
121	Adducted thumb (HP:0001181)	1.36431952
122	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.36040566

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PIK3CG	7.07000902
2	MUSK	6.79161502
3	MOS	5.52356257
4	TRIB3	5.11796592
5	PIM2	3.09769058
6	MAPK15	2.59989586
7	EEF2K	2.48137945
8	PKN2	2.40086880
9	MAP3K10	2.23056207
10	OBSCN	2.12003448
11	ICK	2.01386571
12	CCNB1	1.96580817
13	MAPKAPK3	1.93663220
14	PAK4	1.79799249
15	MAP2K3	1.70660481
16	CDK6	1.69216154
17	ILK	1.67247316
18	DDR2	1.57750855
19	MAP2K1	1.53720440
20	TRPM7	1.49428889
21	ROCK2	1.45650354
22	TTN	1.39526484
23	EPHB1	1.38066919
24	CDK14	1.31356713
25	CDK15	1.29750714
26	CDK18	1.23377293
27	CDK11A	1.22068121
28	DYRK1B	1.22046244
29	LATS2	1.18336631
30	PDGFRA	1.13059627
31	MAPK12	1.06657126
32	ROCK1	1.04362403
33	AKT2	1.03108559
34	NME1	1.02536825
35	LRRK2	1.01812338
36	PTK6	1.00299757
37	LATS1	0.94801814
38	MAP2K6	0.92829866
39	FGFR4	0.90759734
40	EPHB2	0.90636284
41	RIPK1	0.89406077
42	PRKG1	0.88926311
43	PTK2	0.85468258
44	BRD4	0.82131204
45	MTOR	0.81449749
46	PINK1	0.80990537
47	MAP3K5	0.80263885
48	SIK1	0.79381914
49	NEK9	0.78565430
50	MAPK7	0.73769407
51	DAPK3	0.72622635
52	DMPK	0.71049419
53	TLK1	0.68409952
54	ZAP70	0.62964887
55	MARK2	0.62178001
56	WNK4	0.62065896
57	MAPK11	0.61711681
58	MAP2K4	0.59573384
59	LIMK1	0.57479053
60	SGK1	0.57364228
61	RPS6KB2	0.56183005
62	BCKDK	0.54986907
63	FLT3	0.53760033
64	RAF1	0.53176788
65	BLK	0.51169678
66	BMX	0.49409873
67	PDK2	0.48762613
68	PRKD2	0.46902844
69	MARK1	0.46395810
70	PAK6	0.46099784
71	TYRO3	0.46096098
72	MAP3K6	0.42665133
73	MELK	0.42504697
74	* RPS6KA3	0.41180222
75	INSR	0.40935505
76	MAPKAPK2	0.39904702
77	MAPK10	0.39666382
78	ABL2	0.39179251
79	STK10	0.38689419
80	ABL1	0.36319381
81	RPS6KB1	0.36191896
82	CAMK4	0.35828129
83	PRKAA2	0.35022064
84	PTK2B	0.34792961
85	PRKACB	0.33733728
86	CAMK2G	0.33555062
87	FGFR1	0.33335897
88	MAP3K13	0.32908875
89	CAMK2D	0.29852957
90	NTRK1	0.29788852
91	CDK5	0.29560507
92	SGK3	0.29521054
93	CAMK2A	0.29434877
94	PAK2	0.29369731
95	FER	0.29262403
96	FGR	0.28108488
97	PHKG2	0.27301990
98	PHKG1	0.27301990
99	RPS6KA2	0.26731094
100	MAP3K7	0.26635135
101	ADRBK1	0.26490096
102	PIK3CA	0.26168333
103	PRKACA	0.25943222
104	TAOK2	0.25920210
105	STK11	0.25787782
106	RPS6KA6	0.25136816
107	CSNK1D	0.25067152
108	RPS6KC1	0.24907948
109	RPS6KL1	0.24907948
110	PRKAA1	0.24596929
111	WNK1	0.23852683
112	PDPK1	0.23277836
113	PAK1	0.22794022
114	CDK9	0.22729836
115	PDGFRB	0.21931517
116	BMPR1B	0.21629087
117	ALK	0.21542558
118	CAMK1	0.21167428
119	MET	0.21150196
120	KSR1	0.20937037
121	STK16	0.20426980
122	PKN1	0.20179275
123	CDK8	0.18805035
124	CAMK2B	0.18187212
125	MAPK4	0.17927238
126	CDK4	0.17659973
127	RET	0.17168034
128	TIE1	0.17137133
129	CSNK1E	0.17020586
130	KSR2	0.16892436
131	RPS6KA1	0.16756240
132	ARAF	0.16651855
133	TGFBR2	0.16287955
134	RPS6KA5	0.15762489
135	EPHA2	0.15090362
136	ERBB4	0.14552780
137	CDK12	0.14552693
138	MAPK8	0.14521437
139	PAK3	0.13847970
140	HIPK2	0.12846531
141	PRKD1	0.12825007
142	MAPK9	0.12554140
143	CSK	0.12442707
144	ERBB2	0.12022044
145	PRKCA	0.11547570

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	6.08058478
2	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	5.84538325
3	Dilated cardiomyopathy_Homo sapiens_hsa05414	5.76064669
4	Cardiac muscle contraction_Homo sapiens_hsa04260	2.77876225
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.64328356
6	Focal adhesion_Homo sapiens_hsa04510	2.63146241
7	ECM-receptor interaction_Homo sapiens_hsa04512	2.62017631
8	Tight junction_Homo sapiens_hsa04530	2.44938406
9	Proteoglycans in cancer_Homo sapiens_hsa05205	2.07011225
10	Viral myocarditis_Homo sapiens_hsa05416	1.92134435
11	Sulfur relay system_Homo sapiens_hsa04122	1.88946818
12	Adherens junction_Homo sapiens_hsa04520	1.81555477
13	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.75817931
14	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.75681763
15	Bladder cancer_Homo sapiens_hsa05219	1.67427357
16	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.66611981
17	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	1.57788791
18	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.52083592
19	Amoebiasis_Homo sapiens_hsa05146	1.47965783
20	Leukocyte transendothelial migration_Homo sapiens_hsa04670	1.28846051
21	Arginine biosynthesis_Homo sapiens_hsa00220	1.24724645
22	Protein digestion and absorption_Homo sapiens_hsa04974	1.21978911
23	Arginine and proline metabolism_Homo sapiens_hsa00330	1.17878647
24	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.16841015
25	Insulin signaling pathway_Homo sapiens_hsa04910	1.16535248
26	Hippo signaling pathway_Homo sapiens_hsa04390	1.14385894
27	Lysine degradation_Homo sapiens_hsa00310	1.13490399
28	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.05946621
29	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.05907731
30	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.05871555
31	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.04934942
32	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	1.04292765
33	MAPK signaling pathway_Homo sapiens_hsa04010	1.03539520
34	Nitrogen metabolism_Homo sapiens_hsa00910	1.02598688
35	Basal cell carcinoma_Homo sapiens_hsa05217	1.02064300
36	Small cell lung cancer_Homo sapiens_hsa05222	1.01973756
37	mTOR signaling pathway_Homo sapiens_hsa04150	1.01679603
38	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.01313477
39	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.00531715
40	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.99683123
41	Glioma_Homo sapiens_hsa05214	0.98619914
42	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.98584461
43	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.97631424
44	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.94782258
45	Renin secretion_Homo sapiens_hsa04924	0.93375118
46	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.91907114
47	MicroRNAs in cancer_Homo sapiens_hsa05206	0.91297358
48	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.90828081
49	FoxO signaling pathway_Homo sapiens_hsa04068	0.88225163
50	Melanoma_Homo sapiens_hsa05218	0.88208207
51	GnRH signaling pathway_Homo sapiens_hsa04912	0.87990366
52	p53 signaling pathway_Homo sapiens_hsa04115	0.86977834
53	Glucagon signaling pathway_Homo sapiens_hsa04922	0.85635940
54	Gastric acid secretion_Homo sapiens_hsa04971	0.84112287
55	VEGF signaling pathway_Homo sapiens_hsa04370	0.82869830
56	Renal cell carcinoma_Homo sapiens_hsa05211	0.80936354
57	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.80831021
58	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.80138755
59	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.80117240
60	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.78994191
61	Notch signaling pathway_Homo sapiens_hsa04330	0.78864233
62	Pancreatic cancer_Homo sapiens_hsa05212	0.77810177
63	Axon guidance_Homo sapiens_hsa04360	0.77691625
64	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.77554603
65	Alcoholism_Homo sapiens_hsa05034	0.77232897
66	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.75893939
67	Prostate cancer_Homo sapiens_hsa05215	0.75723784
68	ErbB signaling pathway_Homo sapiens_hsa04012	0.75101075
69	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.72927483
70	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.72305221
71	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.71401240
72	Melanogenesis_Homo sapiens_hsa04916	0.70821159
73	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.69971346
74	Wnt signaling pathway_Homo sapiens_hsa04310	0.69826203
75	AMPK signaling pathway_Homo sapiens_hsa04152	0.69177526
76	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.68446308
77	Long-term potentiation_Homo sapiens_hsa04720	0.66827416
78	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.66785588
79	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.66772649
80	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.65597467
81	Pentose phosphate pathway_Homo sapiens_hsa00030	0.63328427
82	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.63030380
83	Carbon metabolism_Homo sapiens_hsa01200	0.62952640
84	Platelet activation_Homo sapiens_hsa04611	0.62510128
85	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.61318462
86	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.61165936
87	Endometrial cancer_Homo sapiens_hsa05213	0.61038849
88	Pyruvate metabolism_Homo sapiens_hsa00620	0.60159131
89	Renin-angiotensin system_Homo sapiens_hsa04614	0.58228804
90	Acute myeloid leukemia_Homo sapiens_hsa05221	0.57348626
91	Circadian rhythm_Homo sapiens_hsa04710	0.56700710
92	Salivary secretion_Homo sapiens_hsa04970	0.56668929
93	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.54054629
94	Estrogen signaling pathway_Homo sapiens_hsa04915	0.53807133
95	Phototransduction_Homo sapiens_hsa04744	0.53427320
96	* Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.51669053
97	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.51570930
98	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.51142091
99	Pathways in cancer_Homo sapiens_hsa05200	0.50861730
100	Insulin resistance_Homo sapiens_hsa04931	0.50067387
101	Gap junction_Homo sapiens_hsa04540	0.49971305
102	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.49640534
103	HTLV-I infection_Homo sapiens_hsa05166	0.49478293
104	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.49235531
105	Salmonella infection_Homo sapiens_hsa05132	0.47899718
106	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.47555436
107	Prion diseases_Homo sapiens_hsa05020	0.47171037
108	Colorectal cancer_Homo sapiens_hsa05210	0.46746574
109	Circadian entrainment_Homo sapiens_hsa04713	0.45255446
110	Cholinergic synapse_Homo sapiens_hsa04725	0.43544618
111	Toxoplasmosis_Homo sapiens_hsa05145	0.43169858
112	cAMP signaling pathway_Homo sapiens_hsa04024	0.41598141
113	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.38383853
114	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.37503686
115	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.37364118
116	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.37125173
117	Calcium signaling pathway_Homo sapiens_hsa04020	0.36856875
118	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.36359837
119	Non-small cell lung cancer_Homo sapiens_hsa05223	0.36297160
120	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.34219853
121	Apoptosis_Homo sapiens_hsa04210	0.33888964
122	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.33261850
123	Thyroid cancer_Homo sapiens_hsa05216	0.32576122
124	Long-term depression_Homo sapiens_hsa04730	0.32553767
125	Ras signaling pathway_Homo sapiens_hsa04014	0.31783474
126	Alzheimers disease_Homo sapiens_hsa05010	0.31727556
127	Fatty acid degradation_Homo sapiens_hsa00071	0.31541604
128	Prolactin signaling pathway_Homo sapiens_hsa04917	0.31221399
129	Hepatitis B_Homo sapiens_hsa05161	0.30755774
130	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.30713980
131	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.30562749
132	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.30532102
133	Endocytosis_Homo sapiens_hsa04144	0.30266189
134	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.30258408
135	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.30115466
136	Choline metabolism in cancer_Homo sapiens_hsa05231	0.29769083
137	Amphetamine addiction_Homo sapiens_hsa05031	0.29258944
138	Rap1 signaling pathway_Homo sapiens_hsa04015	0.28689457
139	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.28080373
140	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.27962262
141	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.27935686
142	Insulin secretion_Homo sapiens_hsa04911	0.27752132
143	Viral carcinogenesis_Homo sapiens_hsa05203	0.27415600

CHRNG

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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