CHST1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus encodes a member of the keratin sulfotransferase family of proteins. The encoded enzyme catalyzes the sulfation of the proteoglycan keratin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.18566831
2locomotory exploration behavior (GO:0035641)5.82763933
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.78180368
4synaptic vesicle maturation (GO:0016188)5.77674262
5vocalization behavior (GO:0071625)5.55715412
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.46979446
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.28896481
8regulation of glutamate receptor signaling pathway (GO:1900449)5.20926659
9synaptic vesicle exocytosis (GO:0016079)5.12065034
10glutamate secretion (GO:0014047)5.07559123
11synaptic vesicle docking involved in exocytosis (GO:0016081)5.02547123
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.90996159
13regulation of neuronal synaptic plasticity (GO:0048168)4.71982744
14regulation of synaptic vesicle exocytosis (GO:2000300)4.71515193
15regulation of long-term neuronal synaptic plasticity (GO:0048169)4.66618143
16protein localization to synapse (GO:0035418)4.65516430
17exploration behavior (GO:0035640)4.47772922
18regulation of synapse structural plasticity (GO:0051823)4.42615793
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.35864941
20glutamate receptor signaling pathway (GO:0007215)4.35700626
21synaptic transmission, glutamatergic (GO:0035249)4.33578442
22neuronal action potential propagation (GO:0019227)4.31852076
23neurotransmitter secretion (GO:0007269)4.29046903
24neurotransmitter-gated ion channel clustering (GO:0072578)4.28856199
25dendritic spine morphogenesis (GO:0060997)4.25547806
26regulation of synaptic vesicle transport (GO:1902803)4.25220842
27regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.21006597
28neuron cell-cell adhesion (GO:0007158)4.19135507
29long-term memory (GO:0007616)4.09658123
30neuron-neuron synaptic transmission (GO:0007270)4.02648005
31layer formation in cerebral cortex (GO:0021819)3.99256076
32membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.96322568
33regulation of excitatory postsynaptic membrane potential (GO:0060079)3.94724228
34cerebellar granule cell differentiation (GO:0021707)3.93728406
35proline transport (GO:0015824)3.92369175
36regulation of dendritic spine morphogenesis (GO:0061001)3.91645023
37positive regulation of membrane potential (GO:0045838)3.84473022
38cellular potassium ion homeostasis (GO:0030007)3.82278123
39central nervous system myelination (GO:0022010)3.81755295
40axon ensheathment in central nervous system (GO:0032291)3.81755295
41potassium ion homeostasis (GO:0055075)3.81107159
42regulation of synapse maturation (GO:0090128)3.80776075
43gamma-aminobutyric acid transport (GO:0015812)3.78657998
44regulation of synaptic plasticity (GO:0048167)3.77054825
45amino acid import (GO:0043090)3.75793552
46regulation of postsynaptic membrane potential (GO:0060078)3.74208234
47positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.68015063
48G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.66245990
49transmission of nerve impulse (GO:0019226)3.63293764
50regulation of voltage-gated calcium channel activity (GO:1901385)3.60437637
51positive regulation of neurotransmitter secretion (GO:0001956)3.59691248
52potassium ion import (GO:0010107)3.54258405
53positive regulation of synaptic transmission, GABAergic (GO:0032230)3.53076445
54activation of protein kinase A activity (GO:0034199)3.51869128
55neuron recognition (GO:0008038)3.50949350
56regulation of synaptic transmission, glutamatergic (GO:0051966)3.50802932
57neuromuscular process controlling balance (GO:0050885)3.49517467
58sodium ion export (GO:0071436)3.49415266
59positive regulation of neurotransmitter transport (GO:0051590)3.46855023
60neurotransmitter transport (GO:0006836)3.45859303
61long-term synaptic potentiation (GO:0060291)3.45632270
62positive regulation of synapse maturation (GO:0090129)3.43460314
63auditory behavior (GO:0031223)3.40916603
64regulation of vesicle fusion (GO:0031338)3.39450505
65negative regulation of dendrite morphogenesis (GO:0050774)3.34961566
66regulation of dendritic spine development (GO:0060998)3.33908431
67dendritic spine organization (GO:0097061)3.33565649
68regulation of neurotransmitter secretion (GO:0046928)3.31654397
69regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.30490100
70gamma-aminobutyric acid signaling pathway (GO:0007214)3.30311581
71regulation of neurotransmitter levels (GO:0001505)3.29191357
72cellular sodium ion homeostasis (GO:0006883)3.28256422
73response to auditory stimulus (GO:0010996)3.27485076
74prepulse inhibition (GO:0060134)3.26250441
75positive regulation of dendritic spine development (GO:0060999)3.24987413
76axonal fasciculation (GO:0007413)3.21880624
77cell migration in hindbrain (GO:0021535)3.21697805
78membrane depolarization (GO:0051899)3.21500348
79negative regulation of synaptic transmission, GABAergic (GO:0032229)3.21007794
80regulation of ARF protein signal transduction (GO:0032012)3.18699171
81behavioral defense response (GO:0002209)3.18430718
82behavioral fear response (GO:0001662)3.18430718
83synaptic vesicle endocytosis (GO:0048488)3.17452110
84neuronal ion channel clustering (GO:0045161)3.17443225
85cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.14989493
86presynaptic membrane organization (GO:0097090)3.12769953
87L-amino acid import (GO:0043092)3.12525769
88postsynaptic membrane organization (GO:0001941)3.11464450
89membrane depolarization during action potential (GO:0086010)3.10853022
90regulation of neurotransmitter transport (GO:0051588)3.10253981
91membrane hyperpolarization (GO:0060081)3.10196376
92positive regulation of synaptic transmission (GO:0050806)3.10012535
93learning (GO:0007612)3.09978723
94cell communication by electrical coupling (GO:0010644)3.09684983
95negative regulation of amino acid transport (GO:0051956)3.09110203
96glycine transport (GO:0015816)3.07112125
97G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.06813576
98cerebellar Purkinje cell differentiation (GO:0021702)3.05392852
99regulation of female receptivity (GO:0045924)3.04946516
100regulation of synaptic transmission (GO:0050804)3.04749126
101regulation of glutamate secretion (GO:0014048)3.04460217
102fear response (GO:0042596)3.04038038
103response to histamine (GO:0034776)3.03451988
104positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.00527525
105cytoskeletal anchoring at plasma membrane (GO:0007016)2.99764226
106negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.97616940
107neuromuscular process controlling posture (GO:0050884)2.96930214
108positive regulation of dendritic spine morphogenesis (GO:0061003)2.93185133
109synaptic transmission (GO:0007268)2.90396430
110regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.90239603
111positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.90195900
112intraspecies interaction between organisms (GO:0051703)2.90174124
113social behavior (GO:0035176)2.90174124
114cerebellar Purkinje cell layer development (GO:0021680)2.89873711
115long term synaptic depression (GO:0060292)2.88447883
116neuromuscular synaptic transmission (GO:0007274)2.88072069
117establishment of mitochondrion localization (GO:0051654)2.87307883
118mating behavior (GO:0007617)2.87201551
119presynaptic membrane assembly (GO:0097105)2.86899731
120dendrite morphogenesis (GO:0048813)2.86628702
121positive regulation of dendrite development (GO:1900006)2.82917047
122acidic amino acid transport (GO:0015800)2.80682560
123establishment of synaptic vesicle localization (GO:0097480)2.79345930
124synaptic vesicle transport (GO:0048489)2.79345930

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.17355332
2GBX2_23144817_ChIP-Seq_PC3_Human3.25120204
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.19031017
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.11179792
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09453716
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.81669637
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.81538254
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.81538254
9* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.70547690
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.70394538
11* REST_21632747_ChIP-Seq_MESCs_Mouse2.66424744
12DROSHA_22980978_ChIP-Seq_HELA_Human2.62568303
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.62158085
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.59438181
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.58254850
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.55690474
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.49470734
18* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.35614659
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.33515250
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.33472150
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.30628705
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.28728342
23* RNF2_27304074_Chip-Seq_ESCs_Mouse2.21622881
24* REST_18959480_ChIP-ChIP_MESCs_Mouse2.14940291
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.11511789
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.95615726
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86554700
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76024817
29AR_21572438_ChIP-Seq_LNCaP_Human1.75233934
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.71413916
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63398943
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61029766
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54370588
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52223564
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52104232
36SMAD4_21799915_ChIP-Seq_A2780_Human1.50303493
37TAF15_26573619_Chip-Seq_HEK293_Human1.42341771
38ZNF274_21170338_ChIP-Seq_K562_Hela1.37472517
39ZFP281_27345836_Chip-Seq_ESCs_Mouse1.34827293
40SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.34684139
41* RING1B_27294783_Chip-Seq_ESCs_Mouse1.34331065
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31979440
43DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29975590
44TRIM28_21343339_ChIP-Seq_HEK293_Human1.29096604
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27458305
46* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26318648
47* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.26056114
48SOX2_21211035_ChIP-Seq_LN229_Gbm1.25219759
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22909290
50* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22882170
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.22532932
52* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19911124
53P300_19829295_ChIP-Seq_ESCs_Human1.19616062
54AR_25329375_ChIP-Seq_VCAP_Human1.19078926
55OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.17304201
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16675620
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16468823
58* AR_19668381_ChIP-Seq_PC3_Human1.16202545
59TP53_20018659_ChIP-ChIP_R1E_Mouse1.15250943
60WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14767567
61EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13975497
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.13755041
63KDM2B_26808549_Chip-Seq_K562_Human1.13437963
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12881869
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.12723696
66ESR2_21235772_ChIP-Seq_MCF-7_Human1.12563372
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11476032
68STAT3_23295773_ChIP-Seq_U87_Human1.11455175
69RING1B_27294783_Chip-Seq_NPCs_Mouse1.09869840
70LXR_22292898_ChIP-Seq_THP-1_Human1.09401793
71EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09276981
72SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07829089
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06799843
74TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06259858
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05806484
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.05712394
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05193640
78ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04002563
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01480643
80P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00690780
81TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00393585
82OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00239963
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00018875
84ARNT_22903824_ChIP-Seq_MCF-7_Human0.99069323
85TCF4_23295773_ChIP-Seq_U87_Human0.98195402
86ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97852522
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97770270
88* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97166988
89SMAD3_21741376_ChIP-Seq_HESCs_Human0.97047488
90NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96361600
91AHR_22903824_ChIP-Seq_MCF-7_Human0.95884510
92RXR_22108803_ChIP-Seq_LS180_Human0.95741892
93BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94550660
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94485929
95* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94146086
96TP53_16413492_ChIP-PET_HCT116_Human0.93036165
97PRDM14_20953172_ChIP-Seq_ESCs_Human0.92367090
98RUNX2_22187159_ChIP-Seq_PCA_Human0.90884417
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90869313
100SMAD3_21741376_ChIP-Seq_ESCs_Human0.90307109
101GATA1_26923725_Chip-Seq_HPCs_Mouse0.89790100
102ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89089346
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87373253
104AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87130166
105* SMAD4_21741376_ChIP-Seq_HESCs_Human0.86992737
106CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.86663566
107* CTCF_27219007_Chip-Seq_Bcells_Human0.85455623
108TP53_18474530_ChIP-ChIP_U2OS_Human0.84752230
109TET1_21490601_ChIP-Seq_MESCs_Mouse0.84652734
110OCT4_19829295_ChIP-Seq_ESCs_Human0.84390878
111PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84317581
112SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83898840
113PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83425001
114RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83105215
115BCAT_22108803_ChIP-Seq_LS180_Human0.82968765
116RNF2_27304074_Chip-Seq_NSC_Mouse0.82284145
117TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.82246158
118ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.81235891
119DPY_21335234_ChIP-Seq_ESCs_Mouse0.80556269
120KLF4_19829295_ChIP-Seq_ESCs_Human0.80233614
121TP53_23651856_ChIP-Seq_MEFs_Mouse0.76864269
122LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76861834
123SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76770172
124UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.76433451
125* SMC4_20622854_ChIP-Seq_HELA_Human0.73289996
126CTNNB1_20460455_ChIP-Seq_HCT116_Human0.73265842
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.71383001
128TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71383001
129DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.71276087

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.14339620
2MP0003880_abnormal_central_pattern5.00478595
3MP0003635_abnormal_synaptic_transmissio4.29998674
4MP0002822_catalepsy3.78851360
5MP0004270_analgesia3.60695045
6MP0009745_abnormal_behavioral_response3.58527873
7MP0002063_abnormal_learning/memory/cond3.46094152
8MP0002064_seizures3.20563412
9MP0001968_abnormal_touch/_nociception2.87086760
10MP0002572_abnormal_emotion/affect_behav2.84719906
11MP0009046_muscle_twitch2.84113392
12MP0005423_abnormal_somatic_nervous2.67478139
13MP0001486_abnormal_startle_reflex2.67192576
14MP0001501_abnormal_sleep_pattern2.59649095
15MP0002272_abnormal_nervous_system2.57102734
16MP0002734_abnormal_mechanical_nocicepti2.41256466
17MP0002736_abnormal_nociception_after2.17468455
18MP0001440_abnormal_grooming_behavior2.15862518
19MP0009780_abnormal_chondrocyte_physiolo2.15149597
20MP0002735_abnormal_chemical_nociception1.96361728
21MP0003329_amyloid_beta_deposits1.90623026
22MP0002733_abnormal_thermal_nociception1.90365381
23MP0001970_abnormal_pain_threshold1.84816285
24MP0008569_lethality_at_weaning1.84324334
25MP0002909_abnormal_adrenal_gland1.79928332
26MP0002067_abnormal_sensory_capabilities1.77029582
27MP0005646_abnormal_pituitary_gland1.75941044
28MP0004858_abnormal_nervous_system1.68910374
29MP0002557_abnormal_social/conspecific_i1.64428494
30MP0004924_abnormal_behavior1.63015819
31MP0005386_behavior/neurological_phenoty1.63015819
32MP0004811_abnormal_neuron_physiology1.61103519
33MP0003879_abnormal_hair_cell1.59371430
34MP0000778_abnormal_nervous_system1.53000031
35MP0002184_abnormal_innervation1.47918953
36MP0010368_abnormal_lymphatic_system1.45549402
37MP0004885_abnormal_endolymph1.44879544
38MP0003787_abnormal_imprinting1.42949512
39MP0001529_abnormal_vocalization1.42092228
40MP0003633_abnormal_nervous_system1.41345872
41MP0002066_abnormal_motor_capabilities/c1.36479126
42MP0000955_abnormal_spinal_cord1.35913728
43MP0001984_abnormal_olfaction1.34519953
44MP0001905_abnormal_dopamine_level1.32919587
45MP0003075_altered_response_to1.28698230
46MP0002882_abnormal_neuron_morphology1.28402174
47MP0006276_abnormal_autonomic_nervous1.28082790
48MP0003123_paternal_imprinting1.27166479
49MP0005645_abnormal_hypothalamus_physiol1.24737980
50MP0001502_abnormal_circadian_rhythm1.21252181
51MP0003631_nervous_system_phenotype1.14029630
52MP0000013_abnormal_adipose_tissue1.12437476
53MP0003690_abnormal_glial_cell1.12291669
54MP0000751_myopathy1.11153632
55MP0008872_abnormal_physiological_respon1.11034836
56MP0005535_abnormal_body_temperature1.04284057
57MP0008874_decreased_physiological_sensi1.01852696
58MP0002152_abnormal_brain_morphology1.01819806
59MP0005167_abnormal_blood-brain_barrier1.00370317
60MP0001177_atelectasis0.99570028
61MP0002069_abnormal_eating/drinking_beha0.99325987
62MP0004142_abnormal_muscle_tone0.95928638
63MP0001188_hyperpigmentation0.94607314
64MP0002837_dystrophic_cardiac_calcinosis0.89937105
65MP0003122_maternal_imprinting0.89810003
66MP0002876_abnormal_thyroid_physiology0.86792933
67MP0008961_abnormal_basal_metabolism0.85764338
68MP0005623_abnormal_meninges_morphology0.84413904
69MP0000604_amyloidosis0.84149432
70MP0001879_abnormal_lymphatic_vessel0.83430564
71MP0004130_abnormal_muscle_cell0.83224037
72MP0004085_abnormal_heartbeat0.83023107
73MP0010386_abnormal_urinary_bladder0.82726493
74MP0005409_darkened_coat_color0.81137010
75MP0003283_abnormal_digestive_organ0.79635544
76MP0002229_neurodegeneration0.79176856
77MP0002090_abnormal_vision0.76421925
78MP0003634_abnormal_glial_cell0.75845167
79MP0000920_abnormal_myelination0.74976609
80MP0001963_abnormal_hearing_physiology0.74855726
81MP0004215_abnormal_myocardial_fiber0.73118030
82MP0004145_abnormal_muscle_electrophysio0.71931311
83MP0005551_abnormal_eye_electrophysiolog0.70980169
84MP0003632_abnormal_nervous_system0.70032034
85MP0000026_abnormal_inner_ear0.69844847
86MP0001664_abnormal_digestion0.68772327
87MP0004484_altered_response_of0.68454358
88MP0000566_synostosis0.68146798
89MP0002638_abnormal_pupillary_reflex0.65651898
90MP0004742_abnormal_vestibular_system0.65215006
91MP0002089_abnormal_postnatal_growth/wei0.64622028
92MP0001485_abnormal_pinna_reflex0.62299070
93MP0000631_abnormal_neuroendocrine_gland0.60954053
94MP0004510_myositis0.60633085
95MP0001346_abnormal_lacrimal_gland0.59675528
96MP0003861_abnormal_nervous_system0.59359976
97MP0002752_abnormal_somatic_nervous0.58877701
98MP0004233_abnormal_muscle_weight0.58812037
99MP0003121_genomic_imprinting0.58377866
100MP0010769_abnormal_survival0.58050286
101MP0003137_abnormal_impulse_conducting0.57069217
102MP0010234_abnormal_vibrissa_follicle0.56880388
103MP0005499_abnormal_olfactory_system0.56781040
104MP0005394_taste/olfaction_phenotype0.56781040
105MP0010770_preweaning_lethality0.54472903
106MP0002082_postnatal_lethality0.54472903
107MP0001299_abnormal_eye_distance/0.54456458
108MP0003045_fibrosis0.54287450
109MP0000462_abnormal_digestive_system0.54150889
110MP0010768_mortality/aging0.54055977
111MP0001348_abnormal_lacrimal_gland0.50043471
112MP0000569_abnormal_digit_pigmentation0.48715549
113MP0005410_abnormal_fertilization0.48217314
114MP0005595_abnormal_vascular_smooth0.48075302
115MP0005620_abnormal_muscle_contractility0.47849671
116MP0003938_abnormal_ear_development0.47479276
117MP0001943_abnormal_respiration0.47463099
118MP0003956_abnormal_body_size0.46966765
119MP0008877_abnormal_DNA_methylation0.43386867
120MP0002295_abnormal_pulmonary_circulatio0.43233082

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.41455382
2Myokymia (HP:0002411)7.68862999
3Focal seizures (HP:0007359)5.99321339
4Visual hallucinations (HP:0002367)5.37029447
5Epileptic encephalopathy (HP:0200134)4.90160883
6Atonic seizures (HP:0010819)4.41375467
7Febrile seizures (HP:0002373)4.26898673
8Generalized tonic-clonic seizures (HP:0002069)4.06917865
9Absence seizures (HP:0002121)4.03520863
10Progressive cerebellar ataxia (HP:0002073)3.90518147
11Dialeptic seizures (HP:0011146)3.70905736
12Action tremor (HP:0002345)3.69663871
13Supranuclear gaze palsy (HP:0000605)3.64664695
14Impaired vibration sensation in the lower limbs (HP:0002166)3.60280843
15Poor eye contact (HP:0000817)3.49921867
16Broad-based gait (HP:0002136)3.47004574
17Depression (HP:0000716)3.38464213
18Ankle clonus (HP:0011448)3.23817330
19Dysdiadochokinesis (HP:0002075)3.22540682
20Anxiety (HP:0000739)3.22108868
21Abnormal eating behavior (HP:0100738)3.21816950
22Gaze-evoked nystagmus (HP:0000640)3.19323185
23Neurofibrillary tangles (HP:0002185)3.18600194
24Dysmetria (HP:0001310)3.18333649
25Amblyopia (HP:0000646)3.18311995
26Cerebral inclusion bodies (HP:0100314)3.16381522
27Impaired social interactions (HP:0000735)3.14850184
28Abnormal social behavior (HP:0012433)3.14850184
29Akinesia (HP:0002304)3.11274614
30Postural instability (HP:0002172)3.08254842
31Hyperventilation (HP:0002883)2.97362091
32Urinary bladder sphincter dysfunction (HP:0002839)2.96739357
33Abnormality of the lower motor neuron (HP:0002366)2.94687452
34Hemiparesis (HP:0001269)2.93467342
35Truncal ataxia (HP:0002078)2.89597878
36Sleep apnea (HP:0010535)2.84614953
37Diplopia (HP:0000651)2.83019516
38Abnormality of binocular vision (HP:0011514)2.83019516
39Torticollis (HP:0000473)2.82680854
40Mutism (HP:0002300)2.82260633
41Hemiplegia (HP:0002301)2.81449103
42Papilledema (HP:0001085)2.80860859
43Cerebral hypomyelination (HP:0006808)2.79776996
44Peripheral hypomyelination (HP:0007182)2.69706889
45Focal dystonia (HP:0004373)2.68772983
46Megalencephaly (HP:0001355)2.68654192
47Stereotypic behavior (HP:0000733)2.62667449
48Intention tremor (HP:0002080)2.58378708
49Bradykinesia (HP:0002067)2.58274559
50Annular pancreas (HP:0001734)2.55546661
51Urinary urgency (HP:0000012)2.54210861
52Impaired smooth pursuit (HP:0007772)2.48852265
53Impaired vibratory sensation (HP:0002495)2.39012509
54Spastic gait (HP:0002064)2.38429710
55Drooling (HP:0002307)2.37928967
56Excessive salivation (HP:0003781)2.37928967
57Progressive inability to walk (HP:0002505)2.37916417
58Genetic anticipation (HP:0003743)2.37694089
59Craniofacial dystonia (HP:0012179)2.36240274
60Status epilepticus (HP:0002133)2.35733595
61Scanning speech (HP:0002168)2.28201151
62Epileptiform EEG discharges (HP:0011182)2.26014219
63Aplasia of the phalanges of the hand (HP:0009802)2.24911072
64Aplasia involving bones of the extremities (HP:0009825)2.24911072
65Aplasia involving bones of the upper limbs (HP:0009823)2.24911072
66Diminished motivation (HP:0000745)2.24880346
67Ventricular fibrillation (HP:0001663)2.21121840
68Lower limb muscle weakness (HP:0007340)2.20536997
69Tetraplegia (HP:0002445)2.19584218
70Polyphagia (HP:0002591)2.18795485
71Abnormality of ocular smooth pursuit (HP:0000617)2.18768760
72Clonus (HP:0002169)2.16261379
73Pointed chin (HP:0000307)2.13768355
74EEG with generalized epileptiform discharges (HP:0011198)2.12530617
75Rapidly progressive (HP:0003678)2.12524732
76Insidious onset (HP:0003587)2.12350554
77Termporal pattern (HP:0011008)2.12350554
78Insomnia (HP:0100785)2.08676594
79Absent speech (HP:0001344)2.06654319
80Incomplete penetrance (HP:0003829)2.06399987
81Bundle branch block (HP:0011710)2.05082832
82Generalized myoclonic seizures (HP:0002123)2.04757028
83Resting tremor (HP:0002322)2.03554346
84Turricephaly (HP:0000262)2.03406989
85Ankyloglossia (HP:0010296)2.02453817
86Hypsarrhythmia (HP:0002521)2.02085048
87Neuronal loss in central nervous system (HP:0002529)2.01033611
88Lower limb amyotrophy (HP:0007210)2.00511609
89Delusions (HP:0000746)1.99450300
90Limb dystonia (HP:0002451)1.97913898
91Bronchomalacia (HP:0002780)1.97395490
92Abnormal EKG (HP:0003115)1.97042456
93Inability to walk (HP:0002540)1.95812015
94Dysmetric saccades (HP:0000641)1.95721158
95Increased circulating renin level (HP:0000848)1.93001681
96Myotonia (HP:0002486)1.92921670
97Rigidity (HP:0002063)1.92314733
98Gait ataxia (HP:0002066)1.92310983
99Fetal akinesia sequence (HP:0001989)1.90668323
100Thickened helices (HP:0000391)1.88280537
101Obstructive sleep apnea (HP:0002870)1.87646693
102Spinal canal stenosis (HP:0003416)1.87140909
103Spastic tetraparesis (HP:0001285)1.86215608
104Lower limb asymmetry (HP:0100559)1.84553118
105Dynein arm defect of respiratory motile cilia (HP:0012255)1.80856120
106Absent/shortened dynein arms (HP:0200106)1.80856120
107Psychosis (HP:0000709)1.77654406
108Abnormality of the corticospinal tract (HP:0002492)1.76488950
109Split foot (HP:0001839)1.75588608
110Abnormality of the middle phalanges of the toes (HP:0010183)1.74260834
111Prolonged QT interval (HP:0001657)1.72701018
112Anosmia (HP:0000458)1.72190852
113Apathy (HP:0000741)1.72039928
114Hypoventilation (HP:0002791)1.69172656
115Hyperthyroidism (HP:0000836)1.68728810
116Type II lissencephaly (HP:0007260)1.68683541
117Abnormality of the periventricular white matter (HP:0002518)1.67931624
118Choreoathetosis (HP:0001266)1.65367459
119Morphological abnormality of the pyramidal tract (HP:0002062)1.63540042
120CNS hypomyelination (HP:0003429)1.60270476
121Hand muscle atrophy (HP:0009130)1.59884546
122Dementia (HP:0000726)1.58854098

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.85675194
2NTRK34.82161087
3MAP3K93.68252773
4DAPK22.86305826
5MAP3K42.60883123
6PRKD32.48657845
7MINK12.42120850
8KSR22.26912024
9RIPK42.22945596
10MAP2K72.13223552
11PAK62.12695517
12MARK12.09483110
13NTRK21.98574046
14TIE11.94163623
15CAMKK11.81925925
16NTRK11.79000349
17TNIK1.69866717
18MAP2K41.68653017
19DAPK11.64176208
20CDK51.60556612
21PRPF4B1.58317899
22ARAF1.57879905
23KSR11.57021231
24MAP3K121.55033921
25MAP3K131.54208253
26SIK21.51522231
27FES1.49826531
28PLK21.41601556
29STK381.38667221
30GRK51.34243729
31CASK1.25148167
32TYRO31.20013449
33PTK2B1.18191484
34PNCK1.14468579
35PRKCG1.14096243
36MAP3K21.11641874
37MAPK131.08079429
38CAMK11.06623733
39CDK191.04605841
40PKN11.01233718
41TAOK10.98163580
42CAMK2A0.95678842
43RAF10.92752910
44LMTK20.91457408
45UHMK10.90328520
46CDK150.87235396
47CDK180.87093094
48PHKG20.86738946
49PHKG10.86738946
50PRKCH0.85188718
51STK110.84825372
52BMPR20.83813108
53CAMK2B0.83007411
54PINK10.82033866
55CDK140.81644379
56SGK2230.81263923
57SGK4940.81263923
58CAMKK20.79433764
59LATS20.76906143
60CDK11A0.75942800
61PDK10.75864380
62TNK20.75179495
63PDPK10.73434124
64MAP3K110.72780692
65SGK10.71791717
66RET0.70504787
67CAMK1G0.69806312
68MARK20.69042531
69OXSR10.67712817
70SGK20.67460036
71NME10.66737874
72PAK30.66058818
73FGFR20.64236476
74ROCK20.63927629
75FGR0.62273031
76SGK30.62240733
77DYRK1A0.61937340
78LIMK10.60726411
79MAP3K10.60309758
80ALK0.58662545
81TESK10.57671080
82MAP3K70.52519067
83MAP2K10.51993506
84DDR20.50761007
85FER0.50531650
86DAPK30.50445413
87NEK60.48500961
88ROCK10.47886397
89RIPK10.47805771
90RPS6KA30.47333008
91PRKCE0.46648997
92PRKCZ0.45945963
93FYN0.45075165
94RPS6KA20.44207441
95CAMK2D0.42734935
96MAPKAPK50.42511914
97DMPK0.41980652
98CAMK2G0.41576325
99CDC42BPA0.41238560
100CAMK40.40215334
101CSNK1G20.39301862
102MAPK120.39159621
103MAPK100.38449721
104ERBB20.37815549
105DYRK20.37395480
106PRKG20.37164212
107PTK20.36691502
108PDK40.36024847
109PDK30.36024847
110MAP3K60.34865157
111TAOK20.34610815
112PRKD20.34501714
113MUSK0.33012198
114BRSK10.32295329
115MOS0.31310179
116PRKCA0.30832292
117PRKD10.30372105
118BRAF0.28497516

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.57017991
2Synaptic vesicle cycle_Homo sapiens_hsa047213.02865837
3Olfactory transduction_Homo sapiens_hsa047402.83579393
4Long-term potentiation_Homo sapiens_hsa047202.74096835
5Circadian entrainment_Homo sapiens_hsa047132.72862282
6GABAergic synapse_Homo sapiens_hsa047272.62958815
7Glutamatergic synapse_Homo sapiens_hsa047242.61552660
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.60802040
9Amphetamine addiction_Homo sapiens_hsa050312.56801759
10Morphine addiction_Homo sapiens_hsa050322.51475397
11Salivary secretion_Homo sapiens_hsa049702.37404260
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.14716242
13Dopaminergic synapse_Homo sapiens_hsa047282.13165854
14Gastric acid secretion_Homo sapiens_hsa049712.00384492
15Insulin secretion_Homo sapiens_hsa049111.98429509
16Cholinergic synapse_Homo sapiens_hsa047251.91691004
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.90811542
18Renin secretion_Homo sapiens_hsa049241.85078709
19Cocaine addiction_Homo sapiens_hsa050301.77680091
20Calcium signaling pathway_Homo sapiens_hsa040201.72472194
21Oxytocin signaling pathway_Homo sapiens_hsa049211.71907233
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.67595868
23Long-term depression_Homo sapiens_hsa047301.64473995
24Taste transduction_Homo sapiens_hsa047421.63643380
25Serotonergic synapse_Homo sapiens_hsa047261.55153435
26GnRH signaling pathway_Homo sapiens_hsa049121.50013961
27Nitrogen metabolism_Homo sapiens_hsa009101.47433852
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.39858726
29cAMP signaling pathway_Homo sapiens_hsa040241.37383652
30Gap junction_Homo sapiens_hsa045401.33022431
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.31000637
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.30125775
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28012751
34Collecting duct acid secretion_Homo sapiens_hsa049661.26506745
35Glioma_Homo sapiens_hsa052141.15406971
36Estrogen signaling pathway_Homo sapiens_hsa049151.12946969
37Type II diabetes mellitus_Homo sapiens_hsa049301.11043393
38Melanogenesis_Homo sapiens_hsa049161.10659398
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08943751
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08749031
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06325601
42Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.05315492
43Axon guidance_Homo sapiens_hsa043601.00939836
44Vitamin B6 metabolism_Homo sapiens_hsa007500.99230905
45Vascular smooth muscle contraction_Homo sapiens_hsa042700.98223307
46ErbB signaling pathway_Homo sapiens_hsa040120.96231399
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94494097
48Phospholipase D signaling pathway_Homo sapiens_hsa040720.91844186
49Cardiac muscle contraction_Homo sapiens_hsa042600.91801078
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89668282
51Pancreatic secretion_Homo sapiens_hsa049720.87359696
52Dorso-ventral axis formation_Homo sapiens_hsa043200.83178296
53Thyroid hormone synthesis_Homo sapiens_hsa049180.81328838
54Oocyte meiosis_Homo sapiens_hsa041140.80948090
55Vibrio cholerae infection_Homo sapiens_hsa051100.79815108
56Dilated cardiomyopathy_Homo sapiens_hsa054140.77346697
57Choline metabolism in cancer_Homo sapiens_hsa052310.71446034
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71217043
59VEGF signaling pathway_Homo sapiens_hsa043700.69810281
60Fatty acid biosynthesis_Homo sapiens_hsa000610.67475518
61MAPK signaling pathway_Homo sapiens_hsa040100.66084067
62Glucagon signaling pathway_Homo sapiens_hsa049220.65916815
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61966828
64Rap1 signaling pathway_Homo sapiens_hsa040150.61677161
65Phototransduction_Homo sapiens_hsa047440.60111898
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.59865742
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58939320
68Ras signaling pathway_Homo sapiens_hsa040140.57120480
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.53476463
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51529713
71African trypanosomiasis_Homo sapiens_hsa051430.50982330
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50526780
73Histidine metabolism_Homo sapiens_hsa003400.49981123
74Bile secretion_Homo sapiens_hsa049760.49822022
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48228489
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46096722
77Endocytosis_Homo sapiens_hsa041440.45387825
78mTOR signaling pathway_Homo sapiens_hsa041500.44779864
79Type I diabetes mellitus_Homo sapiens_hsa049400.44027109
80Inositol phosphate metabolism_Homo sapiens_hsa005620.43698994
81Non-small cell lung cancer_Homo sapiens_hsa052230.42996109
82Prion diseases_Homo sapiens_hsa050200.42249613
83ECM-receptor interaction_Homo sapiens_hsa045120.42106486
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41986855
85Alcoholism_Homo sapiens_hsa050340.41248690
86Hippo signaling pathway_Homo sapiens_hsa043900.40540897
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40461433
88Wnt signaling pathway_Homo sapiens_hsa043100.40426911
89Circadian rhythm_Homo sapiens_hsa047100.39608516
90Hedgehog signaling pathway_Homo sapiens_hsa043400.39419879
91Insulin signaling pathway_Homo sapiens_hsa049100.39296444
92Arginine biosynthesis_Homo sapiens_hsa002200.38536261
93Tight junction_Homo sapiens_hsa045300.36251759
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35729375
95Arginine and proline metabolism_Homo sapiens_hsa003300.33928394
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33816059
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33714572
98Chemokine signaling pathway_Homo sapiens_hsa040620.33410813
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.32975245
100Ovarian steroidogenesis_Homo sapiens_hsa049130.32862983
101Renal cell carcinoma_Homo sapiens_hsa052110.32150679
102Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30883213
103Focal adhesion_Homo sapiens_hsa045100.30757262
104Alzheimers disease_Homo sapiens_hsa050100.30755152
105Endometrial cancer_Homo sapiens_hsa052130.29127684
106Mineral absorption_Homo sapiens_hsa049780.28224263
107Glycerolipid metabolism_Homo sapiens_hsa005610.27966023
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27864237
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26859883
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25940110
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25475974
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23495962

Most similar genes based on co-expression Upload to Enrichr

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