CHST12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. Alternatively spliced transcript variants differing only in their 5' UTRs have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.08356578
2negative regulation of phagocytosis (GO:0050765)5.04776936
3fucose catabolic process (GO:0019317)4.57084869
4L-fucose metabolic process (GO:0042354)4.57084869
5L-fucose catabolic process (GO:0042355)4.57084869
6DNA deamination (GO:0045006)4.55515176
7Arp2/3 complex-mediated actin nucleation (GO:0034314)4.54675874
8tryptophan catabolic process (GO:0006569)4.22254885
9indole-containing compound catabolic process (GO:0042436)4.22254885
10indolalkylamine catabolic process (GO:0046218)4.22254885
11neutrophil activation involved in immune response (GO:0002283)4.17559149
12ribosomal small subunit assembly (GO:0000028)4.08894936
13sulfation (GO:0051923)4.08730981
14indolalkylamine metabolic process (GO:0006586)4.00572215
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.94054016
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.94054016
17cellular response to exogenous dsRNA (GO:0071360)3.89113938
18kynurenine metabolic process (GO:0070189)3.85726013
19leukocyte aggregation (GO:0070486)3.73528295
20negative regulation of telomere maintenance (GO:0032205)3.73430061
21tryptophan metabolic process (GO:0006568)3.70573704
22respiratory burst (GO:0045730)3.65905280
23regulation of hippo signaling (GO:0035330)3.56292047
24response to peptidoglycan (GO:0032494)3.50494464
25detection of light stimulus involved in sensory perception (GO:0050962)3.48129142
26detection of light stimulus involved in visual perception (GO:0050908)3.48129142
27cellular ketone body metabolic process (GO:0046950)3.44171619
28positive regulation of defense response to virus by host (GO:0002230)3.39399632
29antigen processing and presentation via MHC class Ib (GO:0002475)3.39211102
30regulation of posttranscriptional gene silencing (GO:0060147)3.38534895
31regulation of gene silencing by miRNA (GO:0060964)3.38534895
32regulation of gene silencing by RNA (GO:0060966)3.38534895
33actin nucleation (GO:0045010)3.38376112
34positive regulation of CREB transcription factor activity (GO:0032793)3.37175919
35antigen processing and presentation of endogenous antigen (GO:0019883)3.36990737
36regulation of protein heterodimerization activity (GO:0043497)3.35905848
37response to pheromone (GO:0019236)3.35467818
38NAD biosynthetic process (GO:0009435)3.34760092
39telomere maintenance via semi-conservative replication (GO:0032201)3.34425914
40response to fungus (GO:0009620)3.31705869
41signal peptide processing (GO:0006465)3.31031696
42regulation of B cell receptor signaling pathway (GO:0050855)3.28959674
43defense response to fungus (GO:0050832)3.27103745
44SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.27064902
45DNA strand elongation involved in DNA replication (GO:0006271)3.24539482
46cotranslational protein targeting to membrane (GO:0006613)3.18592885
47neutrophil mediated immunity (GO:0002446)3.18354520
48protein targeting to ER (GO:0045047)3.17675826
49indole-containing compound metabolic process (GO:0042430)3.17450416
50leukocyte migration involved in inflammatory response (GO:0002523)3.15960703
51urinary tract smooth muscle contraction (GO:0014848)3.13659724
52interkinetic nuclear migration (GO:0022027)3.13081306
53protein import into peroxisome matrix (GO:0016558)3.12620435
54DNA strand elongation (GO:0022616)3.12213298
55viral transcription (GO:0019083)3.10261062
56positive regulation of lamellipodium assembly (GO:0010592)3.08292778
57antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.08214798
58positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.07886581
59macrophage differentiation (GO:0030225)3.06024432
60protein localization to endoplasmic reticulum (GO:0070972)3.05298952
61barbed-end actin filament capping (GO:0051016)3.03047095
62ketone body metabolic process (GO:1902224)3.02853756
63endosome to melanosome transport (GO:0035646)3.02373089
64endosome to pigment granule transport (GO:0043485)3.02373089
65epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.01369175
66rRNA catabolic process (GO:0016075)2.99149487
67establishment of protein localization to endoplasmic reticulum (GO:0072599)2.98760061
68translational termination (GO:0006415)2.97771416
69positive regulation of fatty acid transport (GO:2000193)2.97484074
70gamma-aminobutyric acid transport (GO:0015812)2.96501839
71negative regulation of translation, ncRNA-mediated (GO:0040033)2.94219904
72regulation of translation, ncRNA-mediated (GO:0045974)2.94219904
73negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.94219904
74telomere maintenance via recombination (GO:0000722)2.92089995
75cytidine deamination (GO:0009972)2.91927563
76cytidine metabolic process (GO:0046087)2.91927563
77cytidine catabolic process (GO:0006216)2.91927563
78immunoglobulin mediated immune response (GO:0016064)2.91893592
79deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.91333025
80cellular response to ATP (GO:0071318)2.87312096
81Golgi transport vesicle coating (GO:0048200)2.86885288
82COPI coating of Golgi vesicle (GO:0048205)2.86885288
83mitochondrial respiratory chain complex I assembly (GO:0032981)2.86669882
84NADH dehydrogenase complex assembly (GO:0010257)2.86669882
85mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.86669882
86antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.86183257
87pentose-phosphate shunt (GO:0006098)2.85944556
88protein maturation by protein folding (GO:0022417)2.85709983
89detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.84994423
90modulation of growth of symbiont involved in interaction with host (GO:0044144)2.83557938
91regulation of growth of symbiont in host (GO:0044126)2.83557938
92negative regulation of growth of symbiont in host (GO:0044130)2.83557938
93negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.83557938
94neuronal action potential (GO:0019228)2.82619979
95antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.81435819
96primary amino compound metabolic process (GO:1901160)2.80978663
97regulation of histone phosphorylation (GO:0033127)2.80276413
98translational elongation (GO:0006414)2.77430527
99phosphatidylinositol acyl-chain remodeling (GO:0036149)2.77098440
100cilium or flagellum-dependent cell motility (GO:0001539)2.75863542
101neutrophil activation (GO:0042119)2.74704450
102response to interferon-beta (GO:0035456)2.74030485
103maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.74017849
104negative regulation of mast cell activation (GO:0033004)2.73489651
105sequestering of metal ion (GO:0051238)2.73012688
106serotonin metabolic process (GO:0042428)2.71459811
107nucleobase-containing small molecule interconversion (GO:0015949)2.71394455
108protein retention in ER lumen (GO:0006621)2.70362918
109positive regulation of gamma-delta T cell activation (GO:0046645)2.69462764
110peristalsis (GO:0030432)2.69253509
111definitive hemopoiesis (GO:0060216)2.68710650
112leukocyte degranulation (GO:0043299)2.68246973
113purine-containing compound salvage (GO:0043101)2.66776938
114positive regulation of macrophage differentiation (GO:0045651)2.66704402
115autophagic vacuole fusion (GO:0000046)2.66675624
116fucosylation (GO:0036065)2.66432470
117positive regulation of B cell differentiation (GO:0045579)2.66314206
118myeloid leukocyte mediated immunity (GO:0002444)2.66185283
119kidney morphogenesis (GO:0060993)2.65865723
120killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.65030832
121disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.65030832
122regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.64268852
123piRNA metabolic process (GO:0034587)2.63935103
124positive regulation of lamellipodium organization (GO:1902745)2.63133849
125preassembly of GPI anchor in ER membrane (GO:0016254)2.62603176
126IMP metabolic process (GO:0046040)2.61878212
127angiogenesis involved in wound healing (GO:0060055)2.60066919
128negative regulation of systemic arterial blood pressure (GO:0003085)2.59585393
129mast cell activation (GO:0045576)2.59516124
130cornea development in camera-type eye (GO:0061303)2.58827287
131positive regulation of fatty acid oxidation (GO:0046321)2.58456215
132regulation of mesoderm development (GO:2000380)2.57069584
133amine catabolic process (GO:0009310)2.56718902
134cellular biogenic amine catabolic process (GO:0042402)2.56718902
135membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.55893452
136DNA replication initiation (GO:0006270)2.55348827
137mature B cell differentiation involved in immune response (GO:0002313)2.54974640
138negative regulation of reactive oxygen species metabolic process (GO:2000378)2.54959332
139pyrimidine ribonucleoside catabolic process (GO:0046133)2.54296014
140regulation of telomere maintenance (GO:0032204)2.53609880
141positive regulation of icosanoid secretion (GO:0032305)2.53552673
142sequestering of actin monomers (GO:0042989)2.53251946
143protein complex biogenesis (GO:0070271)2.53159335
144regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.53059101
145response to misfolded protein (GO:0051788)2.53045153
146regulation of B cell differentiation (GO:0045577)2.52916235
147axoneme assembly (GO:0035082)2.52890682
148cardiovascular system development (GO:0072358)2.52427232
149DNA methylation involved in gamete generation (GO:0043046)2.52407909
150regulation of rhodopsin mediated signaling pathway (GO:0022400)2.52014880
151purinergic nucleotide receptor signaling pathway (GO:0035590)2.51108968
152multicellular organism reproduction (GO:0032504)2.50548954
153negative regulation of myeloid cell apoptotic process (GO:0033033)2.49459659
154ribosomal small subunit biogenesis (GO:0042274)2.48754418
155maturation of SSU-rRNA (GO:0030490)2.48455739
156mitotic recombination (GO:0006312)2.48265500
157B cell receptor signaling pathway (GO:0050853)2.47655057
158negative regulation of interleukin-1 beta production (GO:0032691)2.47233037
159NADPH regeneration (GO:0006740)2.46022864
160rhodopsin mediated signaling pathway (GO:0016056)2.45828567
161glycoside metabolic process (GO:0016137)2.45561189
162regulation of nuclear cell cycle DNA replication (GO:0033262)2.45117337
163protein polyglutamylation (GO:0018095)2.44206305
164fibril organization (GO:0097435)2.43359080
165activated T cell proliferation (GO:0050798)2.43253614
166viral life cycle (GO:0019058)2.42701749
167B cell mediated immunity (GO:0019724)2.42598316
168IMP biosynthetic process (GO:0006188)2.41745115
169nicotinamide nucleotide biosynthetic process (GO:0019359)2.41552389
170pyridine nucleotide biosynthetic process (GO:0019363)2.41552389
171pseudouridine synthesis (GO:0001522)2.41378135
172negative regulation of interleukin-1 production (GO:0032692)2.41296569
173megakaryocyte development (GO:0035855)2.40916349
1743-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.40597791
175purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.40597791
176oxidative demethylation (GO:0070989)2.40427847
177granulocyte activation (GO:0036230)2.40163159
178positive regulation of fatty acid beta-oxidation (GO:0032000)2.39859544
179antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.39116096
180protein K48-linked deubiquitination (GO:0071108)2.38828999
181translational initiation (GO:0006413)2.38792375
182cellular protein complex disassembly (GO:0043624)2.38700577
183telomere maintenance via telomere lengthening (GO:0010833)2.38020745
184positive regulation of prostaglandin secretion (GO:0032308)2.37919677
185reciprocal meiotic recombination (GO:0007131)2.37614915
186reciprocal DNA recombination (GO:0035825)2.37614915
187positive regulation of triglyceride biosynthetic process (GO:0010867)2.37322339
188DNA demethylation (GO:0080111)2.37308861
189negative regulation of erythrocyte differentiation (GO:0045647)2.36618311
190regulation of mast cell activation (GO:0033003)2.35781150
191cellular response to zinc ion (GO:0071294)2.35220927
192T cell apoptotic process (GO:0070231)2.32190541
193iron-sulfur cluster assembly (GO:0016226)2.30471555
194metallo-sulfur cluster assembly (GO:0031163)2.30471555
195platelet aggregation (GO:0070527)2.29282983
196platelet dense granule organization (GO:0060155)2.28876023

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.10059192
2EZH2_22144423_ChIP-Seq_EOC_Human4.27465763
3ZNF274_21170338_ChIP-Seq_K562_Hela4.08840961
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.63118311
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.07234061
6MYB_21317192_ChIP-Seq_ERMYB_Mouse2.85790054
7SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.79028079
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.73521312
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.69909195
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.69123227
11VDR_22108803_ChIP-Seq_LS180_Human2.64199679
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.60371954
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.59797794
14* MYC_18555785_ChIP-Seq_MESCs_Mouse2.55941178
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.55663245
16VDR_21846776_ChIP-Seq_THP-1_Human2.53270198
17FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.36224617
18* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.35279995
19GBX2_23144817_ChIP-Seq_PC3_Human2.31560954
20MYC_22102868_ChIP-Seq_BL_Human2.30278642
21IRF8_22096565_ChIP-ChIP_GC-B_Human2.28994233
22SPI1_23547873_ChIP-Seq_NB4_Human2.28265164
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.27007016
24* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.24211176
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.21422093
26SCL_19346495_ChIP-Seq_HPC-7_Human2.18240414
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.16673201
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14243781
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.08957179
30SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.08166651
31DROSHA_22980978_ChIP-Seq_HELA_Human2.06709808
32EST1_17652178_ChIP-ChIP_JURKAT_Human2.06443400
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.03389099
34MYC_18358816_ChIP-ChIP_MESCs_Mouse2.00091865
35VDR_24763502_ChIP-Seq_THP-1_Human1.97882365
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.96850697
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.92840190
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.91566833
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.89029644
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.86868159
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.86483423
42STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.82445994
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.81854150
44* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.80399518
45IRF1_19129219_ChIP-ChIP_H3396_Human1.77344195
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.77267733
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.75461252
48* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.74932776
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.74796748
50* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74144459
51VDR_23849224_ChIP-Seq_CD4+_Human1.73451929
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.72046063
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71596602
54SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.69603840
55* MYB_26560356_Chip-Seq_TH2_Human1.69041681
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.68932114
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66452316
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65511288
59REST_21632747_ChIP-Seq_MESCs_Mouse1.65139738
60ER_23166858_ChIP-Seq_MCF-7_Human1.65087023
61MYC_19030024_ChIP-ChIP_MESCs_Mouse1.64145352
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63951922
63* XRN2_22483619_ChIP-Seq_HELA_Human1.63710251
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60799141
65* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.59873684
66FOXP3_21729870_ChIP-Seq_TREG_Human1.59474151
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.58923723
68AR_21572438_ChIP-Seq_LNCaP_Human1.58655541
69MAF_26560356_Chip-Seq_TH1_Human1.57741079
70IRF8_27001747_Chip-Seq_BMDM_Mouse1.54924785
71* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.54923318
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.52983355
73MYC_19079543_ChIP-ChIP_MESCs_Mouse1.52911021
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.51177111
75IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.48982008
76* ERA_21632823_ChIP-Seq_H3396_Human1.48680483
77TFEB_21752829_ChIP-Seq_HELA_Human1.46544259
78GABP_19822575_ChIP-Seq_HepG2_Human1.46520112
79* UTX_26944678_Chip-Seq_JUKART_Human1.45666247
80LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.45286411
81CREB1_15753290_ChIP-ChIP_HEK293T_Human1.45260456
82* MYB_26560356_Chip-Seq_TH1_Human1.44666393
83EWS_26573619_Chip-Seq_HEK293_Human1.44596009
84DCP1A_22483619_ChIP-Seq_HELA_Human1.44149112
85IGF1R_20145208_ChIP-Seq_DFB_Human1.43796720
86* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.43242197
87CIITA_25753668_ChIP-Seq_RAJI_Human1.42484848
88CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.42313905
89FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41997408
90TP53_22573176_ChIP-Seq_HFKS_Human1.41813602
91ELK3_25401928_ChIP-Seq_HUVEC_Human1.41124167
92GATA1_22383799_ChIP-Seq_G1ME_Mouse1.40387850
93LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39381965
94IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38341703
95STAT3_23295773_ChIP-Seq_U87_Human1.36906521
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36889373
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36889373
98EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.36000557
99SRF_21415370_ChIP-Seq_HL-1_Mouse1.34803858
100BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34598514
101CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.34396778
102NELFA_20434984_ChIP-Seq_ESCs_Mouse1.34194125
103SPI1_23127762_ChIP-Seq_K562_Human1.33044048
104FOXM1_23109430_ChIP-Seq_U2OS_Human1.32825590
105BCAT_22108803_ChIP-Seq_LS180_Human1.30347573
106JARID2_20064375_ChIP-Seq_MESCs_Mouse1.30047425
107EZH2_27294783_Chip-Seq_ESCs_Mouse1.28976678
108FLI1_27457419_Chip-Seq_LIVER_Mouse1.28697265
109CBX2_27304074_Chip-Seq_ESCs_Mouse1.28213020
110SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27842760
111FOXA1_25329375_ChIP-Seq_VCAP_Human1.27281415
112FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27281415
113PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27168267
114JARID2_20075857_ChIP-Seq_MESCs_Mouse1.26040164
115TCF4_23295773_ChIP-Seq_U87_Human1.25550253
116HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25382654
117MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24399097
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24335460
119GATA1_22025678_ChIP-Seq_K562_Human1.24024015
120HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23633012
121MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23470200
122THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23337130
123NANOG_20526341_ChIP-Seq_ESCs_Human1.23179523
124TAF2_19829295_ChIP-Seq_ESCs_Human1.22809425
125CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.22352730
126TTF2_22483619_ChIP-Seq_HELA_Human1.22177665
127ETV2_25802403_ChIP-Seq_MESCs_Mouse1.21570377
128FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.21535275
129* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.21062529
130UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20750498
131VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.20479882
132SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18790723
133CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18223897
134EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17409272
135BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16669081
136YY1_21170310_ChIP-Seq_MESCs_Mouse1.16548368
137P300_19829295_ChIP-Seq_ESCs_Human1.16187991
138HOXB7_26014856_ChIP-Seq_BT474_Human1.14633749
139GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14455073
140RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.14323190
141NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13611328
142TDRD3_21172665_ChIP-Seq_MCF-7_Human1.12969346
143GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12385653
144ELK1_19687146_ChIP-ChIP_HELA_Human1.12378787
145PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11893045
146ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11263816
147P53_21459846_ChIP-Seq_SAOS-2_Human1.11162865
148RUNX_20019798_ChIP-Seq_JUKART_Human1.11072400
149EED_16625203_ChIP-ChIP_MESCs_Mouse1.11034168
150AR_25329375_ChIP-Seq_VCAP_Human1.10381117
151* TCF7_22412390_ChIP-Seq_EML_Mouse1.09934116
152NCOR_22424771_ChIP-Seq_293T_Human1.09599667
153PRDM14_20953172_ChIP-Seq_ESCs_Human1.08962017
154MYC_19829295_ChIP-Seq_ESCs_Human1.08706164
155HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08609214
156AR_20517297_ChIP-Seq_VCAP_Human1.08488569
157GATA3_26560356_Chip-Seq_TH2_Human1.07658478
158SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.07079853
159E2F1_21310950_ChIP-Seq_MCF-7_Human1.06414944
160MAF_26560356_Chip-Seq_TH2_Human1.06283434
161OCT4_20526341_ChIP-Seq_ESCs_Human1.06251739
162PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05397169
163* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04885470
164CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.04418870
165* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04162394
166PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03651492
167SOX2_19829295_ChIP-Seq_ESCs_Human1.03240617
168NANOG_19829295_ChIP-Seq_ESCs_Human1.03240617
169* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02775243
170RAC3_21632823_ChIP-Seq_H3396_Human1.02712585
171OCT1_27270436_Chip-Seq_PROSTATE_Human1.02528940
172RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01264357
173E2F1_20622854_ChIP-Seq_HELA_Human1.01161444
174* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00826533
175CBP_20019798_ChIP-Seq_JUKART_Human1.00205973
176IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00205973
177BCL6_27268052_Chip-Seq_Bcells_Human1.00045201
178ELK1_22589737_ChIP-Seq_MCF10A_Human0.99308122
179RNF2_27304074_Chip-Seq_ESCs_Mouse0.99148723
180SMAD4_21741376_ChIP-Seq_EPCs_Human0.98895507
181CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98889234
182POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98795721
183TAF15_26573619_Chip-Seq_HEK293_Human0.98623637
184FLI1_21867929_ChIP-Seq_TH2_Mouse0.98527002
185FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98304939
186EZH2_27304074_Chip-Seq_ESCs_Mouse0.98152877
187FUS_26573619_Chip-Seq_HEK293_Human0.97553944
188EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97087639
189RNF2_27304074_Chip-Seq_NSC_Mouse0.96960636
190E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96934588
191SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96715016
192RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95282254
193FOXH1_21741376_ChIP-Seq_ESCs_Human0.94815668
194MYC_18940864_ChIP-ChIP_HL60_Human0.94618263

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue3.76990155
2MP0008438_abnormal_cutaneous_collagen3.37639462
3MP0002396_abnormal_hematopoietic_system3.10956662
4MP0003436_decreased_susceptibility_to3.05605551
5MP0003195_calcinosis2.94118095
6MP0001835_abnormal_antigen_presentation2.83554326
7MP0003303_peritoneal_inflammation2.51453951
8MP0004043_abnormal_pH_regulation2.49805228
9MP0000569_abnormal_digit_pigmentation2.43133407
10MP0009785_altered_susceptibility_to2.41279067
11MP0002419_abnormal_innate_immunity2.38982032
12MP0005645_abnormal_hypothalamus_physiol2.36308537
13MP0003724_increased_susceptibility_to2.35774081
14MP0001968_abnormal_touch/_nociception2.31760389
15MP0005671_abnormal_response_to2.28078489
16MP0004147_increased_porphyrin_level2.25837542
17MP0001533_abnormal_skeleton_physiology2.24546339
18MP0006054_spinal_hemorrhage2.22724066
19MP0000685_abnormal_immune_system2.18978615
20MP0009333_abnormal_splenocyte_physiolog2.18775437
21MP0008872_abnormal_physiological_respon2.17954490
22MP0003279_aneurysm2.17868438
23MP0005551_abnormal_eye_electrophysiolog2.17520006
24MP0005464_abnormal_platelet_physiology2.11274857
25MP0005025_abnormal_response_to2.09840673
26MP0005000_abnormal_immune_tolerance2.09173469
27MP0009046_muscle_twitch2.08018316
28MP0002148_abnormal_hypersensitivity_rea2.07877722
29MP0005058_abnormal_lysosome_morphology2.06088061
30MP0002877_abnormal_melanocyte_morpholog2.04662083
31MP0005397_hematopoietic_system_phenotyp2.00678285
32MP0001545_abnormal_hematopoietic_system2.00678285
33MP0002420_abnormal_adaptive_immunity2.00522481
34MP0002452_abnormal_antigen_presenting1.99797817
35MP0004142_abnormal_muscle_tone1.99442650
36MP0004808_abnormal_hematopoietic_stem1.98428674
37MP0002735_abnormal_chemical_nociception1.98382593
38MP0001958_emphysema1.97433621
39MP0001819_abnormal_immune_cell1.97148353
40MP0004130_abnormal_muscle_cell1.95677538
41MP0000858_altered_metastatic_potential1.95476474
42MP0003693_abnormal_embryo_hatching1.89555796
43MP0009745_abnormal_behavioral_response1.89501705
44MP0001800_abnormal_humoral_immune1.87478405
45MP0003172_abnormal_lysosome_physiology1.87315649
46MP0002398_abnormal_bone_marrow1.85369994
47MP0002933_joint_inflammation1.83997954
48MP0002653_abnormal_ependyma_morphology1.83774995
49MP0002876_abnormal_thyroid_physiology1.83398742
50MP0008877_abnormal_DNA_methylation1.82919468
51MP0002723_abnormal_immune_serum1.81483902
52MP0003183_abnormal_peptide_metabolism1.79563844
53MP0005174_abnormal_tail_pigmentation1.78659270
54MP0005646_abnormal_pituitary_gland1.75018574
55MP0006292_abnormal_olfactory_placode1.75008168
56MP0001501_abnormal_sleep_pattern1.73660063
57MP0003136_yellow_coat_color1.71701799
58MP0002405_respiratory_system_inflammati1.70961482
59MP0000465_gastrointestinal_hemorrhage1.70630520
60MP0002837_dystrophic_cardiac_calcinosis1.65597119
61MP0001485_abnormal_pinna_reflex1.65265419
62MP0000716_abnormal_immune_system1.63869852
63MP0001790_abnormal_immune_system1.63165415
64MP0005387_immune_system_phenotype1.63165415
65MP0003763_abnormal_thymus_physiology1.58734946
66MP0000490_abnormal_crypts_of1.58666824
67MP0002638_abnormal_pupillary_reflex1.58607722
68MP0000689_abnormal_spleen_morphology1.58565210
69MP0005167_abnormal_blood-brain_barrier1.56052217
70MP0002166_altered_tumor_susceptibility1.55374239
71MP0005503_abnormal_tendon_morphology1.55042169
72MP0000343_altered_response_to1.54530458
73MP0001986_abnormal_taste_sensitivity1.54240625
74MP0002722_abnormal_immune_system1.54132274
75MP0002102_abnormal_ear_morphology1.52944608
76MP0002733_abnormal_thermal_nociception1.52503474
77MP0002429_abnormal_blood_cell1.52369344
78MP0003566_abnormal_cell_adhesion1.49891489
79MP0005390_skeleton_phenotype1.49024781
80MP0004145_abnormal_muscle_electrophysio1.47550486
81MP0005023_abnormal_wound_healing1.46805752
82MP0008875_abnormal_xenobiotic_pharmacok1.46644199
83MP0002272_abnormal_nervous_system1.43873406
84MP0001970_abnormal_pain_threshold1.43548175
85MP0004885_abnormal_endolymph1.42416746
86MP0002736_abnormal_nociception_after1.41819169
87MP0000015_abnormal_ear_pigmentation1.39159265
88MP0004957_abnormal_blastocyst_morpholog1.38930396
89MP0002064_seizures1.38235206
90MP0001853_heart_inflammation1.37171314
91MP0002160_abnormal_reproductive_system1.36238274
92MP0008007_abnormal_cellular_replicative1.35389920
93MP0009278_abnormal_bone_marrow1.35276246
94MP0005275_abnormal_skin_tensile1.32575228
95MP0006276_abnormal_autonomic_nervous1.31798680
96MP0000230_abnormal_systemic_arterial1.30873855
97MP0004133_heterotaxia1.29653224
98MP0001845_abnormal_inflammatory_respons1.28055007
99MP0002572_abnormal_emotion/affect_behav1.24158183
100MP0009379_abnormal_foot_pigmentation1.23590946
101MP0000427_abnormal_hair_cycle1.22444616
102MP0008961_abnormal_basal_metabolism1.22380296
103MP0000631_abnormal_neuroendocrine_gland1.21217326
104MP0005389_reproductive_system_phenotype1.20681245
105MP0010094_abnormal_chromosome_stability1.18934784
106MP0004742_abnormal_vestibular_system1.17346422
107MP0001542_abnormal_bone_strength1.15650465
108MP0010155_abnormal_intestine_physiology1.14992663
109MP0002006_tumorigenesis1.14483679
110MP0002067_abnormal_sensory_capabilities1.13158560
111MP0000703_abnormal_thymus_morphology1.12489232
112MP0001486_abnormal_startle_reflex1.11021789
113MP0003077_abnormal_cell_cycle1.10041223
114MP0005410_abnormal_fertilization1.09410929
115MP0003448_altered_tumor_morphology1.09086695
116MP0002557_abnormal_social/conspecific_i1.07801475
117MP0004924_abnormal_behavior1.07263255
118MP0005386_behavior/neurological_phenoty1.07263255
119MP0009764_decreased_sensitivity_to1.06559956
120MP0000383_abnormal_hair_follicle1.06075499
121MP0002019_abnormal_tumor_incidence1.04809981
122MP0001905_abnormal_dopamine_level1.04007521
123MP0003635_abnormal_synaptic_transmissio1.03154153
124MP0001664_abnormal_digestion1.02018963
125MP0003111_abnormal_nucleus_morphology1.01807865
126MP0003787_abnormal_imprinting1.01674155
127MP0010352_gastrointestinal_tract_polyps1.01545091
128MP0002928_abnormal_bile_duct1.00415197
129MP0003718_maternal_effect1.00131461
130MP0005253_abnormal_eye_physiology0.99893619
131MP0005448_abnormal_energy_balance0.99808225
132MP0002095_abnormal_skin_pigmentation0.99074332
133MP0001851_eye_inflammation0.99040996
134MP0002063_abnormal_learning/memory/cond0.94844934
135MP0002938_white_spotting0.93548236
136MP0003866_abnormal_defecation0.92364111
137MP0005377_hearing/vestibular/ear_phenot0.92335844
138MP0003878_abnormal_ear_physiology0.92335844
139MP0001663_abnormal_digestive_system0.91713307
140MP0010307_abnormal_tumor_latency0.91054563
141MP0002089_abnormal_postnatal_growth/wei0.90977821
142MP0002998_abnormal_bone_remodeling0.90707416
143MP0003795_abnormal_bone_structure0.89723834
144MP0003137_abnormal_impulse_conducting0.87141994
145MP0005084_abnormal_gallbladder_morpholo0.86553839
146MP0008469_abnormal_protein_level0.86542524
147MP0000358_abnormal_cell_content/0.86403594
148MP0005266_abnormal_metabolism0.85729897
149MP0001919_abnormal_reproductive_system0.85585698
150MP0000470_abnormal_stomach_morphology0.85026269
151MP0008775_abnormal_heart_ventricle0.84323000
152MP0002693_abnormal_pancreas_physiology0.82128116
153MP0005310_abnormal_salivary_gland0.81824460
154MP0005195_abnormal_posterior_eye0.80839294
155MP0005164_abnormal_response_to0.79009151
156MP0000249_abnormal_blood_vessel0.79007635
157MP0010386_abnormal_urinary_bladder0.78733716
158MP0005075_abnormal_melanosome_morpholog0.78364765
159MP0006072_abnormal_retinal_apoptosis0.77718100
160MP0000681_abnormal_thyroid_gland0.77221437
161MP0001348_abnormal_lacrimal_gland0.77002940
162MP0003656_abnormal_erythrocyte_physiolo0.76849742
163MP0003300_gastrointestinal_ulcer0.76207491
164MP0003828_pulmonary_edema0.76108264
165MP0003045_fibrosis0.76057311
166MP0003638_abnormal_response/metabolism_0.75340146
167MP0006082_CNS_inflammation0.75175141
168MP0001765_abnormal_ion_homeostasis0.73782012
169MP0002138_abnormal_hepatobiliary_system0.73297400
170MP0001873_stomach_inflammation0.72765865
171MP0000538_abnormal_urinary_bladder0.72680740
172MP0000313_abnormal_cell_death0.72591531
173MP0001963_abnormal_hearing_physiology0.72164163
174MP0005508_abnormal_skeleton_morphology0.71603256
175MP0002132_abnormal_respiratory_system0.68743735
176MP0002060_abnormal_skin_morphology0.67901718
177MP0004947_skin_inflammation0.67810192
178MP0008932_abnormal_embryonic_tissue0.66329644
179MP0001243_abnormal_dermal_layer0.65306365
180MP0000372_irregular_coat_pigmentation0.64839753
181MP0005621_abnormal_cell_physiology0.64766228
182MP0003075_altered_response_to0.64052412

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.71293225
2Birth length less than 3rd percentile (HP:0003561)4.46592066
3Congenital stationary night blindness (HP:0007642)4.43041913
4Thrombocytosis (HP:0001894)4.28605187
5Pancreatic cysts (HP:0001737)4.24876101
6Eczematoid dermatitis (HP:0000976)4.22317843
7Abnormality of midbrain morphology (HP:0002418)4.14405760
8Molar tooth sign on MRI (HP:0002419)4.14405760
9Protrusio acetabuli (HP:0003179)4.06393624
10Elevated erythrocyte sedimentation rate (HP:0003565)4.01679786
11Genetic anticipation (HP:0003743)3.94708462
12Recurrent bacterial skin infections (HP:0005406)3.87430275
13Vertebral compression fractures (HP:0002953)3.68865680
14Clumsiness (HP:0002312)3.67363332
15Hyperventilation (HP:0002883)3.64330485
16Aplastic anemia (HP:0001915)3.61017286
17Myositis (HP:0100614)3.60078418
18Pancreatic fibrosis (HP:0100732)3.56380605
19Nephronophthisis (HP:0000090)3.49038315
20True hermaphroditism (HP:0010459)3.48340933
21Attenuation of retinal blood vessels (HP:0007843)3.45678780
22Beaking of vertebral bodies (HP:0004568)3.39946431
23Premature rupture of membranes (HP:0001788)3.37441230
24Type II lissencephaly (HP:0007260)3.26618330
25Protruding tongue (HP:0010808)3.26119315
26Inability to walk (HP:0002540)3.24928759
27Vacuolated lymphocytes (HP:0001922)3.14295163
28Patellar aplasia (HP:0006443)3.13517165
29Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.12033743
30Progressive cerebellar ataxia (HP:0002073)3.11246276
31Chronic obstructive pulmonary disease (HP:0006510)3.10506147
32Obstructive lung disease (HP:0006536)3.10506147
33Cellulitis (HP:0100658)3.06898794
34IgM deficiency (HP:0002850)3.05221373
35Decreased circulating renin level (HP:0003351)3.03982006
36Abnormality of the renal medulla (HP:0100957)3.03969189
37Aplasia/Hypoplasia of the patella (HP:0006498)2.99424109
38Abolished electroretinogram (ERG) (HP:0000550)2.98431675
39Petechiae (HP:0000967)2.98110577
40Dysostosis multiplex (HP:0000943)2.97145440
41Type I transferrin isoform profile (HP:0003642)2.93580733
42Abnormality of macrophages (HP:0004311)2.90191061
43Chronic otitis media (HP:0000389)2.86650932
44Abnormality of the renal cortex (HP:0011035)2.85347367
45Cervical subluxation (HP:0003308)2.81849404
46Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.81646577
47Abnormality of alanine metabolism (HP:0010916)2.81646577
48Hyperalaninemia (HP:0003348)2.81646577
49Decreased electroretinogram (ERG) amplitude (HP:0000654)2.78267120
50Biconcave vertebral bodies (HP:0004586)2.75977239
51Cystic liver disease (HP:0006706)2.74376061
52Reticulocytopenia (HP:0001896)2.73059196
53Gaze-evoked nystagmus (HP:0000640)2.71840713
54Reduced antithrombin III activity (HP:0001976)2.70141024
55Joint stiffness (HP:0001387)2.68971083
56Polydipsia (HP:0001959)2.67724644
57Abnormal drinking behavior (HP:0030082)2.67724644
58Peritonitis (HP:0002586)2.67137149
59Abnormal rod and cone electroretinograms (HP:0008323)2.65547156
60Pendular nystagmus (HP:0012043)2.61375284
61Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.61106900
62Abnormal protein N-linked glycosylation (HP:0012347)2.61106900
63Abnormal protein glycosylation (HP:0012346)2.61106900
64Abnormal glycosylation (HP:0012345)2.61106900
65Hypoplasia of the pons (HP:0012110)2.58505899
66Increased neuronal autofluorescent lipopigment (HP:0002074)2.58187150
67Abnormality of the pons (HP:0007361)2.57547282
68Progressive inability to walk (HP:0002505)2.55752493
69Breast hypoplasia (HP:0003187)2.55704765
70Spondylolisthesis (HP:0003302)2.54359756
71Large for gestational age (HP:0001520)2.54109213
72Tubular atrophy (HP:0000092)2.51676354
73Abnormal number of erythroid precursors (HP:0012131)2.49551659
74Recurrent fungal infections (HP:0002841)2.48484980
75Interstitial pulmonary disease (HP:0006530)2.46999249
76Decreased central vision (HP:0007663)2.46397084
77Absent rod-and cone-mediated responses on ERG (HP:0007688)2.45896569
78Chronic hepatic failure (HP:0100626)2.44481932
79Meningitis (HP:0001287)2.44345353
80Increased cerebral lipofuscin (HP:0011813)2.43983006
81Abnormality of T cell physiology (HP:0011840)2.43633437
82Recurrent skin infections (HP:0001581)2.42243192
83Absent/shortened dynein arms (HP:0200106)2.38987466
84Dynein arm defect of respiratory motile cilia (HP:0012255)2.38987466
85Cerebellar dysplasia (HP:0007033)2.37893928
86Abnormal delayed hypersensitivity skin test (HP:0002963)2.34458855
87Aplasia/Hypoplasia of the tibia (HP:0005772)2.34105287
88Furrowed tongue (HP:0000221)2.33072243
89Mediastinal lymphadenopathy (HP:0100721)2.31374283
90Abnormality of cells of the erythroid lineage (HP:0012130)2.30902065
91Thoracic kyphosis (HP:0002942)2.29851358
92Broad-based gait (HP:0002136)2.29662953
93Recurrent gram-negative bacterial infections (HP:0005420)2.28548374
94Aortic dissection (HP:0002647)2.28146916
95Lissencephaly (HP:0001339)2.24965483
96Concave nail (HP:0001598)2.24694883
97Urinary glycosaminoglycan excretion (HP:0003541)2.24422800
98Mucopolysacchariduria (HP:0008155)2.24422800
99Increased corneal curvature (HP:0100692)2.24385150
100Keratoconus (HP:0000563)2.24385150
101Microretrognathia (HP:0000308)2.23940205
102Orchitis (HP:0100796)2.22794918
103Ankle contracture (HP:0006466)2.22238495
104Chorioretinal atrophy (HP:0000533)2.21959274
105Poor head control (HP:0002421)2.20439098
106Recurrent viral infections (HP:0004429)2.19147668
107Stomach cancer (HP:0012126)2.18839642
108Bony spicule pigmentary retinopathy (HP:0007737)2.17542584
109Prolonged bleeding time (HP:0003010)2.17317062
110Soft skin (HP:0000977)2.16502958
111Recurrent bronchitis (HP:0002837)2.14732300
112Bulbous nose (HP:0000414)2.13936495
113Gingivitis (HP:0000230)2.12650405
114Cerebral aneurysm (HP:0004944)2.12038229
115Abnormality of the lumbar spine (HP:0100712)2.10261403
116Nonimmune hydrops fetalis (HP:0001790)2.09484995
117Polyuria (HP:0000103)2.08143419
118Medial flaring of the eyebrow (HP:0010747)2.07965692
119Broad face (HP:0000283)2.04770673
120Pulmonary infiltrates (HP:0002113)2.04224640
121Pulmonary fibrosis (HP:0002206)2.03562436
122Congenital, generalized hypertrichosis (HP:0004540)2.02390838
123Aortic aneurysm (HP:0004942)1.99396900
124Epistaxis (HP:0000421)1.99090889
125Congenital hepatic fibrosis (HP:0002612)1.97802170
126Abnormality of the renal collecting system (HP:0004742)1.97675747
127Abnormality of polysaccharide metabolism (HP:0011012)1.97573272
128Abnormality of glycosaminoglycan metabolism (HP:0004371)1.97573272
129Abnormality of mucopolysaccharide metabolism (HP:0011020)1.97573272
130Leukocytosis (HP:0001974)1.96566242
131Abnormality of the nasal mucosa (HP:0000433)1.96083381
132Severe muscular hypotonia (HP:0006829)1.95904934
133Congenital sensorineural hearing impairment (HP:0008527)1.94753225
134Slender build (HP:0001533)1.94595027
135Degeneration of anterior horn cells (HP:0002398)1.93218941
136Abnormality of the anterior horn cell (HP:0006802)1.93218941
137Abnormality of skull ossification (HP:0002703)1.93192235
138Sclerocornea (HP:0000647)1.93184987
139Hypergammaglobulinemia (HP:0010702)1.91482304
140Eosinophilia (HP:0001880)1.91357067
141Anencephaly (HP:0002323)1.91017383
142Periodontitis (HP:0000704)1.90619033
143Hypoplasia of the odontoid process (HP:0003311)1.90292910
144Entropion (HP:0000621)1.89990263
145Fair hair (HP:0002286)1.88263279
146Slender long bone (HP:0003100)1.87668271
147Partial agenesis of the corpus callosum (HP:0001338)1.86194115
148B lymphocytopenia (HP:0010976)1.85313111
149Abnormality of B cell number (HP:0010975)1.85313111
150Stomatitis (HP:0010280)1.85054495
151Nasal polyposis (HP:0100582)1.84709073
152Abnormal respiratory epithelium morphology (HP:0012253)1.84427798
153Abnormal respiratory motile cilium morphology (HP:0005938)1.84427798
154Abnormal biliary tract physiology (HP:0012439)1.84356091
155Bile duct proliferation (HP:0001408)1.84356091
156Osteomyelitis (HP:0002754)1.84229557
157Granulocytopenia (HP:0001913)1.84167119
158Febrile seizures (HP:0002373)1.83846502
159Chest pain (HP:0100749)1.82554800
160Abnormality of the thoracic spine (HP:0100711)1.81877050
161Widely spaced teeth (HP:0000687)1.81443407
162Abnormality of the acetabulum (HP:0003170)1.81345342
163Abnormality of binocular vision (HP:0011514)1.80554494
164Diplopia (HP:0000651)1.80554494
165Visual hallucinations (HP:0002367)1.80401667
166Hemiplegia (HP:0002301)1.80365883
167Progressive neurologic deterioration (HP:0002344)1.80050828
168Absent speech (HP:0001344)1.79422388
169Abnormality of liposaccharide metabolism (HP:0010968)1.77427760
170Abnormality of glycosphingolipid metabolism (HP:0004343)1.77427760
171Abnormality of glycolipid metabolism (HP:0010969)1.77427760
172Mesangial abnormality (HP:0001966)1.77285473
173Radial bowing (HP:0002986)1.74901455
174Skin ulcer (HP:0200042)1.74797942
175Abnormality of T cells (HP:0002843)1.74739519
176Papilledema (HP:0001085)1.74660364
177Dilatation of the ascending aorta (HP:0005111)1.74459027
178Lymphopenia (HP:0001888)1.74109919
17911 pairs of ribs (HP:0000878)1.74014727
180Impaired smooth pursuit (HP:0007772)1.73012000
181Decreased skull ossification (HP:0004331)1.72457961
182J-shaped sella turcica (HP:0002680)1.72224647
183Ketosis (HP:0001946)1.71888142
184Abnormal ciliary motility (HP:0012262)1.71337507
185Male pseudohermaphroditism (HP:0000037)1.67459352
186Duplicated collecting system (HP:0000081)1.66673919
187Abnormality of renin-angiotensin system (HP:0000847)1.65382412
188Tachypnea (HP:0002789)1.64685618
189Gait imbalance (HP:0002141)1.63768193
190Abnormality of DNA repair (HP:0003254)1.63243149
191Macular degeneration (HP:0000608)1.63215019
192Absent thumb (HP:0009777)1.62469058
193Small hand (HP:0200055)1.61267423
194Panhypogammaglobulinemia (HP:0003139)1.61219754
195Retinal dysplasia (HP:0007973)1.60285313

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.11555112
2ADRBK23.65362934
3PIM23.14749932
4TESK22.99338464
5ZAK2.91470369
6MAP4K12.65472173
7ERN12.64292184
8TESK12.57480066
9IRAK42.55276357
10BLK2.45986133
11DAPK22.37956051
12WNK42.27038964
13KIT2.20032467
14MAP3K122.16453349
15STK162.09430926
16ZAP702.08806514
17FLT32.08780131
18GRK12.08148552
19TEC2.06644447
20BTK2.02787144
21BUB11.98962003
22LIMK11.97438470
23INSRR1.96981214
24NME21.90884790
25MAP2K31.85226919
26EIF2AK31.83548929
27ADRBK11.79320183
28WEE11.78898471
29FES1.73904660
30NUAK11.66706846
31MAPKAPK31.59432920
32PASK1.57589747
33MAPK131.54044659
34MAP4K21.53859758
35KDR1.52905271
36PINK11.50745914
37TRIB31.50033997
38JAK31.41804065
39TGFBR11.38339818
40MYLK1.31046439
41PAK41.28914693
42SIK21.28571667
43CSF1R1.27674185
44EEF2K1.26375243
45SCYL21.25173606
46MAP3K111.22842458
47CASK1.22565240
48BCKDK1.22155975
49EIF2AK11.21917841
50LRRK21.20851439
51SYK1.18833057
52TBK11.18271756
53BRSK21.18105404
54MAP2K61.17654944
55CAMKK21.16996265
56TXK1.16324008
57NEK91.15858248
58IRAK31.15046140
59PTK2B1.14653166
60WNK31.11852608
61PKN21.11852303
62TGFBR21.11104669
63EPHB11.10185787
64STK101.09935006
65MATK1.09802030
66OXSR11.08626373
67RPS6KA41.07832603
68MAPK151.03632195
69CDK81.03518011
70CLK11.02945134
71MAP3K71.02314938
72TRPM70.97961860
73ACVR1B0.94828432
74TYK20.93847581
75CDK190.91152205
76ILK0.89642267
77HCK0.89256894
78PRKCQ0.84959138
79LYN0.84259024
80CSK0.82770914
81PIK3CA0.81738681
82PIM10.81291876
83ARAF0.81108899
84PRKG20.80038065
85RIPK40.80017181
86CAMK1D0.79308619
87RAF10.79281145
88LCK0.78567072
89TAOK30.77639877
90VRK10.77062819
91CDK70.76348332
92CAMK10.76253371
93TIE10.74716691
94RPS6KA50.74400118
95PKN10.74221469
96GRK70.73564368
97CDC70.72852146
98MAPKAPK50.68618321
99PAK10.66477787
100TNK20.66454365
101GRK60.65976816
102RPS6KB20.64744918
103IKBKE0.63326651
104PRKD20.63184381
105STK390.63087325
106IKBKB0.62184934
107NTRK30.61571696
108CCNB10.61420720
109MAP3K80.60272759
110MAPK40.59721245
111DAPK10.59564701
112MAPKAPK20.59546241
113RPS6KA60.57361378
114PRKCG0.57011006
115MELK0.56967371
116STK110.56771263
117CHUK0.55747562
118PIK3CG0.55614140
119MKNK20.55522229
120RPS6KC10.55213174
121RPS6KL10.55213174
122TNIK0.54996380
123PRKAA20.54740195
124SIK30.53511384
125TSSK60.53499169
126BRSK10.52208090
127EPHA30.51403695
128CAMK40.50891290
129NTRK20.50509427
130CAMKK10.49346117
131BMPR1B0.47633035
132ITK0.47242361
133GRK50.46930671
134HIPK20.45916611
135NME10.45899532
136MAP2K70.45851713
137MUSK0.45771110
138MAP2K20.45694921
139TTN0.45230057
140PAK20.44966587
141MOS0.44814109
142NEK20.44536138
143RPS6KA20.44164327
144MAP3K40.43987674
145BRAF0.43641195
146MKNK10.43402788
147MAP2K10.42078250
148WNK10.41450470
149TLK10.40968204
150DYRK20.39561387
151MAPK110.39411160
152PRKCH0.39285162
153PRKCE0.38509705
154CAMK2A0.38489394
155STK380.38348920
156CAMK1G0.36681627
157PRKACA0.36192864
158SGK20.34357945
159PAK30.34110252
160MARK30.33366732
161PRKAA10.32995834
162PRKCI0.31179173
163PRKCA0.30478749
164OBSCN0.30197911
165MAPK120.29985985

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.45710206
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.92667177
3Linoleic acid metabolism_Homo sapiens_hsa005912.79079283
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.59573875
5Ribosome_Homo sapiens_hsa030102.55654436
6Phototransduction_Homo sapiens_hsa047442.54264364
7Nitrogen metabolism_Homo sapiens_hsa009102.45154524
8Other glycan degradation_Homo sapiens_hsa005112.43588037
9Protein export_Homo sapiens_hsa030602.41977760
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.24561543
11* Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.21500229
12Mismatch repair_Homo sapiens_hsa034302.11598588
13Proteasome_Homo sapiens_hsa030502.08213967
14Base excision repair_Homo sapiens_hsa034102.06612679
15Nicotine addiction_Homo sapiens_hsa050332.04613785
16Leishmaniasis_Homo sapiens_hsa051402.02900736
17Butanoate metabolism_Homo sapiens_hsa006502.01434484
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.97846836
19ABC transporters_Homo sapiens_hsa020101.92851246
20Tryptophan metabolism_Homo sapiens_hsa003801.75365377
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.73412722
22Shigellosis_Homo sapiens_hsa051311.73281509
23Ether lipid metabolism_Homo sapiens_hsa005651.71260549
24Selenocompound metabolism_Homo sapiens_hsa004501.68576340
25N-Glycan biosynthesis_Homo sapiens_hsa005101.64697159
26Olfactory transduction_Homo sapiens_hsa047401.64410994
27Homologous recombination_Homo sapiens_hsa034401.63749172
28Antigen processing and presentation_Homo sapiens_hsa046121.62581677
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.60137210
30Lysosome_Homo sapiens_hsa041421.55763726
31Morphine addiction_Homo sapiens_hsa050321.54528001
32Sulfur relay system_Homo sapiens_hsa041221.52381883
33Nucleotide excision repair_Homo sapiens_hsa034201.49860407
34Primary immunodeficiency_Homo sapiens_hsa053401.48597830
35Graft-versus-host disease_Homo sapiens_hsa053321.48224432
36Taste transduction_Homo sapiens_hsa047421.47801011
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47309043
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46299715
39Pyrimidine metabolism_Homo sapiens_hsa002401.45793344
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.45473724
41RNA polymerase_Homo sapiens_hsa030201.43987263
42Cell cycle_Homo sapiens_hsa041101.39861750
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.38982054
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.34802912
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.33719735
46Spliceosome_Homo sapiens_hsa030401.32461574
47Hematopoietic cell lineage_Homo sapiens_hsa046401.28894661
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.28124774
49p53 signaling pathway_Homo sapiens_hsa041151.26638222
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.25716258
51Osteoclast differentiation_Homo sapiens_hsa043801.25372498
52Arachidonic acid metabolism_Homo sapiens_hsa005901.25344797
53B cell receptor signaling pathway_Homo sapiens_hsa046621.23436850
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.23381499
55Malaria_Homo sapiens_hsa051441.22763682
56Ovarian steroidogenesis_Homo sapiens_hsa049131.22462403
57Calcium signaling pathway_Homo sapiens_hsa040201.21972767
58Steroid hormone biosynthesis_Homo sapiens_hsa001401.21230726
59Phagosome_Homo sapiens_hsa041451.19651233
60Pertussis_Homo sapiens_hsa051331.18809462
61Measles_Homo sapiens_hsa051621.16260359
62Legionellosis_Homo sapiens_hsa051341.15929280
63Glycerolipid metabolism_Homo sapiens_hsa005611.15210116
64Allograft rejection_Homo sapiens_hsa053301.14970490
65Acute myeloid leukemia_Homo sapiens_hsa052211.14919689
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.14667560
67Autoimmune thyroid disease_Homo sapiens_hsa053201.12539801
68Leukocyte transendothelial migration_Homo sapiens_hsa046701.11930838
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10810609
70Tuberculosis_Homo sapiens_hsa051521.10461430
71Circadian entrainment_Homo sapiens_hsa047131.09810199
72Caffeine metabolism_Homo sapiens_hsa002321.09556696
73Serotonergic synapse_Homo sapiens_hsa047261.08731525
74Apoptosis_Homo sapiens_hsa042101.06730780
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.05221361
76SNARE interactions in vesicular transport_Homo sapiens_hsa041301.04772503
77Chemical carcinogenesis_Homo sapiens_hsa052041.04453742
78Platelet activation_Homo sapiens_hsa046111.04362956
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.02594678
80Thyroid cancer_Homo sapiens_hsa052161.02418190
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01879125
82Glutamatergic synapse_Homo sapiens_hsa047241.01237663
83Epstein-Barr virus infection_Homo sapiens_hsa051691.01080344
84Salmonella infection_Homo sapiens_hsa051321.00655298
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99034972
86Herpes simplex infection_Homo sapiens_hsa051680.98654197
87Hepatitis B_Homo sapiens_hsa051610.97597505
88Toxoplasmosis_Homo sapiens_hsa051450.95042643
89Pentose phosphate pathway_Homo sapiens_hsa000300.93753215
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92911572
91Peroxisome_Homo sapiens_hsa041460.92902240
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92460280
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.92384160
94Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92193557
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91916901
96Insulin secretion_Homo sapiens_hsa049110.91311590
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90894700
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.89450670
99NF-kappa B signaling pathway_Homo sapiens_hsa040640.89249118
100Salivary secretion_Homo sapiens_hsa049700.89173510
101Non-homologous end-joining_Homo sapiens_hsa034500.89160782
102RNA transport_Homo sapiens_hsa030130.88390785
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.88346901
104GABAergic synapse_Homo sapiens_hsa047270.86362617
105RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85521308
106Dorso-ventral axis formation_Homo sapiens_hsa043200.83794550
107Jak-STAT signaling pathway_Homo sapiens_hsa046300.83485353
108Chronic myeloid leukemia_Homo sapiens_hsa052200.82580895
109Type I diabetes mellitus_Homo sapiens_hsa049400.82089777
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.81472017
111Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80628594
112Fanconi anemia pathway_Homo sapiens_hsa034600.78202794
113Purine metabolism_Homo sapiens_hsa002300.75666541
114Pancreatic cancer_Homo sapiens_hsa052120.74931320
115Histidine metabolism_Homo sapiens_hsa003400.74560158
116Primary bile acid biosynthesis_Homo sapiens_hsa001200.74091919
117Vitamin digestion and absorption_Homo sapiens_hsa049770.73155512
118Retinol metabolism_Homo sapiens_hsa008300.72030125
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71915003
120AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71474674
121Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69895950
122Oxidative phosphorylation_Homo sapiens_hsa001900.69874650
123Oxytocin signaling pathway_Homo sapiens_hsa049210.68865619
124Viral carcinogenesis_Homo sapiens_hsa052030.68285927
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67824231
126Chemokine signaling pathway_Homo sapiens_hsa040620.67720586
127Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67526286
128Basal transcription factors_Homo sapiens_hsa030220.67164143
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67153169
130RNA degradation_Homo sapiens_hsa030180.66991410
131Influenza A_Homo sapiens_hsa051640.66683698
132Renin-angiotensin system_Homo sapiens_hsa046140.66041552
133Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65814363
134HTLV-I infection_Homo sapiens_hsa051660.65733428
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65421724
136NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63921375
137Gastric acid secretion_Homo sapiens_hsa049710.63656895
138Cholinergic synapse_Homo sapiens_hsa047250.62317837
139One carbon pool by folate_Homo sapiens_hsa006700.62083634
140Asthma_Homo sapiens_hsa053100.60679833
141TNF signaling pathway_Homo sapiens_hsa046680.60367806
142Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59702897
143Viral myocarditis_Homo sapiens_hsa054160.59375439
144Galactose metabolism_Homo sapiens_hsa000520.58616026
145Bladder cancer_Homo sapiens_hsa052190.57743378
146Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57447677
147HIF-1 signaling pathway_Homo sapiens_hsa040660.55795596
148VEGF signaling pathway_Homo sapiens_hsa043700.54144830
149cAMP signaling pathway_Homo sapiens_hsa040240.53421289
150Colorectal cancer_Homo sapiens_hsa052100.51713793
151Focal adhesion_Homo sapiens_hsa045100.50020723
152Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49958876
153Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49883741
154Long-term depression_Homo sapiens_hsa047300.48522298
155Rheumatoid arthritis_Homo sapiens_hsa053230.48340261
156Endocytosis_Homo sapiens_hsa041440.47558656
157Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47461520
158Vibrio cholerae infection_Homo sapiens_hsa051100.46619137
159Cardiac muscle contraction_Homo sapiens_hsa042600.45426932
160Amoebiasis_Homo sapiens_hsa051460.45260386
161Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45120920
162Lysine degradation_Homo sapiens_hsa003100.44841122
163Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44257948
164T cell receptor signaling pathway_Homo sapiens_hsa046600.43764729
165Regulation of autophagy_Homo sapiens_hsa041400.43316877
166Non-small cell lung cancer_Homo sapiens_hsa052230.42849867
167Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42508466
168Parkinsons disease_Homo sapiens_hsa050120.40664010
169Small cell lung cancer_Homo sapiens_hsa052220.40042432
170MAPK signaling pathway_Homo sapiens_hsa040100.37756593
171Cyanoamino acid metabolism_Homo sapiens_hsa004600.34973314
172Staphylococcus aureus infection_Homo sapiens_hsa051500.34317354
173Fat digestion and absorption_Homo sapiens_hsa049750.33349667
174Pancreatic secretion_Homo sapiens_hsa049720.32394165
175Huntingtons disease_Homo sapiens_hsa050160.32024339

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