CHST14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the HNK-1 family of sulfotransferases. The encoded protein transfers sulfate to the C-4 hydroxyl of N-acetylgalactosamine residues in dermatan sulfate. Mutations in this gene have been associated with adducted thumb-clubfoot syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1planar cell polarity pathway involved in neural tube closure (GO:0090179)4.62873644
2chondrocyte proliferation (GO:0035988)4.47846757
3collagen fibril organization (GO:0030199)4.47567980
4protein heterotrimerization (GO:0070208)4.37437823
5regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.22842734
6basement membrane organization (GO:0071711)4.06217628
7regulation of apoptotic process involved in morphogenesis (GO:1902337)3.96096063
8endodermal cell differentiation (GO:0035987)3.94179652
9lymph vessel development (GO:0001945)3.85364788
10sequestering of extracellular ligand from receptor (GO:0035581)3.72882996
11skin morphogenesis (GO:0043589)3.67848961
12wound healing, spreading of epidermal cells (GO:0035313)3.66744418
13tooth mineralization (GO:0034505)3.65692477
14bone trabecula formation (GO:0060346)3.55586329
15type B pancreatic cell proliferation (GO:0044342)3.50726889
16cochlea morphogenesis (GO:0090103)3.44479987
17positive regulation of endothelial cell apoptotic process (GO:2000353)3.43022700
18blood vessel maturation (GO:0001955)3.38125183
19vascular endothelial growth factor signaling pathway (GO:0038084)3.35889246
20cell adhesion mediated by integrin (GO:0033627)3.32210975
21peptidyl-proline hydroxylation (GO:0019511)3.32023832
22Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.30693280
23regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.30423209
24apoptotic cell clearance (GO:0043277)3.30047984
25collagen metabolic process (GO:0032963)3.25640456
26regulation of mammary gland epithelial cell proliferation (GO:0033599)3.17199741
27response to interferon-alpha (GO:0035455)3.16578531
28heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.16307116
29collagen catabolic process (GO:0030574)3.16155657
30barbed-end actin filament capping (GO:0051016)3.12081172
31regulation of establishment of planar polarity (GO:0090175)3.12073612
32convergent extension (GO:0060026)3.10827274
33outflow tract septum morphogenesis (GO:0003148)3.10775929
34fibril organization (GO:0097435)3.08989000
35positive regulation of epithelial to mesenchymal transition (GO:0010718)3.08696158
36wound healing, spreading of cells (GO:0044319)3.07671872
37axon extension involved in axon guidance (GO:0048846)3.07005491
38neuron projection extension involved in neuron projection guidance (GO:1902284)3.07005491
39cell migration involved in heart development (GO:0060973)3.06814588
40COPI coating of Golgi vesicle (GO:0048205)3.04744630
41Golgi transport vesicle coating (GO:0048200)3.04744630
42establishment of apical/basal cell polarity (GO:0035089)3.04131284
43non-canonical Wnt signaling pathway (GO:0035567)3.01960799
44DNA damage induced protein phosphorylation (GO:0006975)3.01837889
45morphogenesis of an endothelium (GO:0003159)3.01297317
46endothelial tube morphogenesis (GO:0061154)3.01297317
47UV protection (GO:0009650)3.00370089
48cell proliferation involved in metanephros development (GO:0072203)2.99623790
49atrioventricular valve morphogenesis (GO:0003181)2.99540653
50regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.97944183
51negative regulation of fatty acid transport (GO:2000192)2.96810278
52multicellular organismal macromolecule metabolic process (GO:0044259)2.96212577
53protein maturation by protein folding (GO:0022417)2.95895327
54cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.92428962
55atrial septum morphogenesis (GO:0060413)2.91321873
56mesenchymal-epithelial cell signaling (GO:0060638)2.91055116
57substrate-dependent cell migration (GO:0006929)2.90896795
58cell migration involved in sprouting angiogenesis (GO:0002042)2.90065956
59regulation of SMAD protein import into nucleus (GO:0060390)2.90060955
60protein hydroxylation (GO:0018126)2.89990426
61cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.87181188
62positive regulation of blood vessel endothelial cell migration (GO:0043536)2.86105077
63anatomical structure regression (GO:0060033)2.85885797
64multicellular organismal catabolic process (GO:0044243)2.85645221
65extracellular matrix disassembly (GO:0022617)2.84603176
66mammary gland epithelial cell differentiation (GO:0060644)2.82781904
67antigen processing and presentation via MHC class Ib (GO:0002475)2.82672804
68antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.77921997
69regulation of protein heterodimerization activity (GO:0043497)2.76727753
70multicellular organismal metabolic process (GO:0044236)2.76497529
71cellular response to vitamin (GO:0071295)2.76210034
72proline biosynthetic process (GO:0006561)2.74413272
73epithelial cell-cell adhesion (GO:0090136)2.74177593
74negative regulation of cell size (GO:0045792)2.72030903
75pattern specification involved in kidney development (GO:0061004)2.71625550
76extracellular fibril organization (GO:0043206)2.70357542
77negative regulation of embryonic development (GO:0045992)2.70278835
78regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.70234856
79outer ear morphogenesis (GO:0042473)2.69432618
80substrate adhesion-dependent cell spreading (GO:0034446)2.67782816
81positive regulation of natural killer cell differentiation (GO:0032825)2.67621962
82cellular response to interferon-alpha (GO:0035457)2.67301031
83endothelial cell morphogenesis (GO:0001886)2.67268049
84blood vessel endothelial cell migration (GO:0043534)2.66864702
85muscle cell fate commitment (GO:0042693)2.66304983
86regulation of tight junction assembly (GO:2000810)2.64801037
87heterochromatin organization (GO:0070828)2.64730503
88regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.64681543
89negative regulation of phagocytosis (GO:0050765)2.62699094
90apoptotic process involved in morphogenesis (GO:0060561)2.60016727
91hyaluronan catabolic process (GO:0030214)2.58721506
92negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.57902672
93retina vasculature morphogenesis in camera-type eye (GO:0061299)2.57779065
94middle ear morphogenesis (GO:0042474)2.54736675
95positive regulation of cartilage development (GO:0061036)2.54362567
96trabecula formation (GO:0060343)2.54303981
97negative regulation of chondrocyte differentiation (GO:0032331)2.53626688
98embryonic heart tube development (GO:0035050)2.52372396
99embryonic skeletal joint morphogenesis (GO:0060272)2.51678241
100metanephric mesenchyme development (GO:0072075)2.50548242
101membrane protein ectodomain proteolysis (GO:0006509)2.50485214
102endocardial cushion development (GO:0003197)2.50133128
103positive regulation of odontogenesis (GO:0042482)2.49610380
104renal filtration (GO:0097205)2.48995197
105chondroitin sulfate biosynthetic process (GO:0030206)2.48889424
106regulation of glucocorticoid metabolic process (GO:0031943)2.48740695
107platelet aggregation (GO:0070527)2.48268752
108craniofacial suture morphogenesis (GO:0097094)2.48201129
109glomerular filtration (GO:0003094)2.45939112
110heparan sulfate proteoglycan metabolic process (GO:0030201)2.45588056
111regulation of cytokine production involved in inflammatory response (GO:1900015)2.45371804
112Arp2/3 complex-mediated actin nucleation (GO:0034314)2.45253890
113regulation of glomerular filtration (GO:0003093)2.45142023
114endocytic recycling (GO:0032456)2.44992821
115branching involved in salivary gland morphogenesis (GO:0060445)2.44976591
116maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.44079943
117positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.43178387
118adhesion of symbiont to host (GO:0044406)2.41250546
119antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.41102189
120antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.41102189
121cellular response to vitamin D (GO:0071305)2.39116842
122regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.39045202
123dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.38720953
124G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.38260828
125negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.38045780
126deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.38027107
127protein retention in ER lumen (GO:0006621)2.37541080
128T cell apoptotic process (GO:0070231)2.37384244
129positive regulation of histone deacetylation (GO:0031065)2.37153974
130regulation of cardioblast differentiation (GO:0051890)2.37139976
131polarized epithelial cell differentiation (GO:0030859)2.36508541
132glomerular basement membrane development (GO:0032836)2.36017610
133mesoderm formation (GO:0001707)2.35986498
134regulation of heart morphogenesis (GO:2000826)2.35665014
135adherens junction assembly (GO:0034333)2.35497792
136response to laminar fluid shear stress (GO:0034616)2.34488645
137stress fiber assembly (GO:0043149)2.33882284
138kidney mesenchyme development (GO:0072074)2.33195877
139membrane raft organization (GO:0031579)2.31360279
140negative regulation of cartilage development (GO:0061037)2.30989239
141lipopolysaccharide biosynthetic process (GO:0009103)2.30943495
142vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.30503209
143* dermatan sulfate biosynthetic process (GO:0030208)2.29701363
144negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.29598345
145* dermatan sulfate metabolic process (GO:0030205)2.26534192
146regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.26161528
147response to fluid shear stress (GO:0034405)2.25316286
148embryonic cranial skeleton morphogenesis (GO:0048701)2.24424054
149germ cell migration (GO:0008354)2.24038853
150keratan sulfate catabolic process (GO:0042340)2.23586396
151positive regulation of osteoblast proliferation (GO:0033690)2.22769741
152protein localization to cell surface (GO:0034394)2.22222587
153platelet degranulation (GO:0002576)2.21242054
154extracellular matrix organization (GO:0030198)2.21151115
155cell-substrate junction assembly (GO:0007044)2.20189941

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.95396827
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.69950177
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.30800663
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.20149889
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.12800574
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.81553855
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.73622951
8ELK3_25401928_ChIP-Seq_HUVEC_Human2.65522837
9RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.37187964
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.35753794
11CLOCK_20551151_ChIP-Seq_293T_Human2.33838389
12TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.24882871
13VDR_21846776_ChIP-Seq_THP-1_Human2.19317342
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.14180892
15ZNF263_19887448_ChIP-Seq_K562_Human2.12768871
16MYC_22102868_ChIP-Seq_BL_Human2.11283476
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.07611459
18DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.04285274
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.99449412
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.96826803
21CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.95086443
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.92877377
23MYB_21317192_ChIP-Seq_ERMYB_Mouse1.89263116
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.89035759
25IRF8_22096565_ChIP-ChIP_GC-B_Human1.85208364
26ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.81343355
27HIF1A_21447827_ChIP-Seq_MCF-7_Human1.75892773
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.74351751
29MYC_18358816_ChIP-ChIP_MESCs_Mouse1.72613288
30TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71345897
31TET1_21451524_ChIP-Seq_MESCs_Mouse1.71289208
32VDR_24763502_ChIP-Seq_THP-1_Human1.66866684
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.61384705
34IRF8_21731497_ChIP-ChIP_J774_Mouse1.60204817
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.59544625
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.59523187
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.56384580
38WT1_19549856_ChIP-ChIP_CCG9911_Human1.55926685
39TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55388929
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54731937
41TP63_19390658_ChIP-ChIP_HaCaT_Human1.54167599
42SCL_19346495_ChIP-Seq_HPC-7_Human1.52268992
43MAF_26560356_Chip-Seq_TH1_Human1.51660483
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51456598
45JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.50938427
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.49698644
47BP1_19119308_ChIP-ChIP_Hs578T_Human1.48996568
48MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48556188
49MYC_19030024_ChIP-ChIP_MESCs_Mouse1.48265360
50POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.45130121
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.44447859
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44218563
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.43760156
54ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.43104696
55SA1_27219007_Chip-Seq_ERYTHROID_Human1.42902625
56TP53_20018659_ChIP-ChIP_R1E_Mouse1.42553324
57* LXR_22292898_ChIP-Seq_THP-1_Human1.42310884
58ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.41823567
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41384910
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.40752967
61KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.40642082
62FOXM1_23109430_ChIP-Seq_U2OS_Human1.40250453
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40053908
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39272671
65HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.37904337
66KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36155556
67RACK7_27058665_Chip-Seq_MCF-7_Human1.36118296
68TCF7_22412390_ChIP-Seq_EML_Mouse1.35064334
69ATF3_27146783_Chip-Seq_COLON_Human1.33786478
70UTX_26944678_Chip-Seq_JUKART_Human1.32969498
71SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.32237429
72BRD4_25478319_ChIP-Seq_HGPS_Human1.32197944
73CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.30264578
74FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.29386165
75CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.28874825
76TFEB_21752829_ChIP-Seq_HELA_Human1.28805077
77E2F7_22180533_ChIP-Seq_HELA_Human1.28543673
78KDM2B_26808549_Chip-Seq_DND41_Human1.28271469
79DCP1A_22483619_ChIP-Seq_HELA_Human1.28169449
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26994531
81SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26768861
82UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.25963302
83WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25353002
84SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25178908
85EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.24045358
86ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23673998
87TTF2_22483619_ChIP-Seq_HELA_Human1.23300233
88* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22466311
89SMC1_22415368_ChIP-Seq_MEFs_Mouse1.22328068
90TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22120329
91CTCF_18555785_ChIP-Seq_MESCs_Mouse1.21353032
92* SPI1_23547873_ChIP-Seq_NB4_Human1.21335231
93RUNX1_22412390_ChIP-Seq_EML_Mouse1.21138951
94KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20655475
95P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20241403
96SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18387493
97SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18387493
98GATA2_21666600_ChIP-Seq_HMVEC_Human1.18295833
99E2F1_18555785_ChIP-Seq_MESCs_Mouse1.18152630
100CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.15946685
101* UBF1/2_26484160_Chip-Seq_HMECs_Human1.15473522
102PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14799140
103NOTCH1_21737748_ChIP-Seq_TLL_Human1.14770182
104SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13716947
105NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.12667996
106STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.11142178
107TP53_22127205_ChIP-Seq_IMR90_Human1.10260364
108IRF8_27001747_Chip-Seq_BMDM_Mouse1.10153083
109* KDM2B_26808549_Chip-Seq_K562_Human1.10082080
110* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09785050
111SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09608654
112CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09416014
113* NCOR1_26117541_ChIP-Seq_K562_Human1.08823860
114NELFA_20434984_ChIP-Seq_ESCs_Mouse1.08376881
115IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.08371872
116FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08078780
117P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07706965
118POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07244273
119CJUN_26792858_Chip-Seq_BT549_Human1.06946646
120SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06783431
121STAT4_19710469_ChIP-ChIP_TH1__Mouse1.06546012
122STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05917623
123EED_16625203_ChIP-ChIP_MESCs_Mouse1.05575442
124STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.05008293
125ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04307498
126ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04277745
127P68_20966046_ChIP-Seq_HELA_Human1.04270987
128IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03669290
129FOXP1_21924763_ChIP-Seq_HESCs_Human1.02516353
130GABP_19822575_ChIP-Seq_HepG2_Human1.00896961
131ELF1_20517297_ChIP-Seq_JURKAT_Human1.00868358
132MYB_26560356_Chip-Seq_TH2_Human1.00438597
133MYCN_18555785_ChIP-Seq_MESCs_Mouse1.00319530
134KDM2B_26808549_Chip-Seq_JURKAT_Human0.98493608
135KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98263410
136ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97930923
137AR_21909140_ChIP-Seq_LNCAP_Human0.97712695
138ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97572948
139XRN2_22483619_ChIP-Seq_HELA_Human0.97434926
140KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97020580
141SA1_22415368_ChIP-Seq_MEFs_Mouse0.96362745
142FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96110778
143CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95913419
144SPI1_23127762_ChIP-Seq_K562_Human0.95802363
145SMC3_22415368_ChIP-Seq_MEFs_Mouse0.94713902
146SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.94039663
147MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.92060562

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.17844945
2MP0003705_abnormal_hypodermis_morpholog4.01284136
3MP0005503_abnormal_tendon_morphology3.65217164
4MP0005275_abnormal_skin_tensile3.53343303
5MP0003279_aneurysm3.35462080
6MP0001958_emphysema2.86781338
7MP0006054_spinal_hemorrhage2.70800524
8MP0004272_abnormal_basement_membrane2.54740929
9MP0010368_abnormal_lymphatic_system2.30209097
10MP0009384_cardiac_valve_regurgitation2.16528805
11MP0003566_abnormal_cell_adhesion2.12614836
12MP0004858_abnormal_nervous_system2.09528823
13MP0005023_abnormal_wound_healing2.07110830
14MP0002249_abnormal_larynx_morphology2.02301462
15MP0010352_gastrointestinal_tract_polyps1.83783520
16MP0010030_abnormal_orbit_morphology1.82894605
17MP0005508_abnormal_skeleton_morphology1.69310647
18MP0000767_abnormal_smooth_muscle1.68083585
19MP0005257_abnormal_intraocular_pressure1.67923361
20MP0005623_abnormal_meninges_morphology1.67683695
21MP0001879_abnormal_lymphatic_vessel1.66276452
22MP0004808_abnormal_hematopoietic_stem1.58428079
23MP0000733_abnormal_muscle_development1.58336083
24MP0002060_abnormal_skin_morphology1.51248914
25MP0003385_abnormal_body_wall1.46900300
26MP0003091_abnormal_cell_migration1.45687401
27MP0000003_abnormal_adipose_tissue1.36691101
28MP0002933_joint_inflammation1.35342199
29MP0009250_abnormal_appendicular_skeleto1.33307390
30MP0004233_abnormal_muscle_weight1.33059628
31MP0002295_abnormal_pulmonary_circulatio1.32236065
32MP0002396_abnormal_hematopoietic_system1.32117091
33MP0001243_abnormal_dermal_layer1.30694529
34MP0005390_skeleton_phenotype1.27572403
35MP0003300_gastrointestinal_ulcer1.27321893
36MP0002163_abnormal_gland_morphology1.26952059
37MP0009278_abnormal_bone_marrow1.25925594
38MP0000343_altered_response_to1.25595327
39MP0000678_abnormal_parathyroid_gland1.25534736
40MP0000762_abnormal_tongue_morphology1.24026419
41MP0003283_abnormal_digestive_organ1.21747999
42MP0001533_abnormal_skeleton_physiology1.20573334
43MP0005058_abnormal_lysosome_morphology1.20013454
44MP0005171_absent_coat_pigmentation1.16734981
45MP0000685_abnormal_immune_system1.15951398
46MP0000750_abnormal_muscle_regeneration1.13057743
47MP0002998_abnormal_bone_remodeling1.11409055
48MP0002697_abnormal_eye_size1.10366906
49MP0000858_altered_metastatic_potential1.09479775
50MP0001542_abnormal_bone_strength1.09354116
51MP0002932_abnormal_joint_morphology1.07875869
52MP0002116_abnormal_craniofacial_bone1.07422349
53MP0003303_peritoneal_inflammation1.05921061
54MP0009053_abnormal_anal_canal1.05500545
55MP0002877_abnormal_melanocyte_morpholog1.03565472
56MP0003436_decreased_susceptibility_to1.02663131
57MP0002128_abnormal_blood_circulation1.01694320
58MP0002896_abnormal_bone_mineralization1.01606625
59MP0002113_abnormal_skeleton_development1.01526740
60MP0002282_abnormal_trachea_morphology1.01089200
61MP0003942_abnormal_urinary_system1.00387142
62MP0002092_abnormal_eye_morphology0.99588015
63MP0005397_hematopoietic_system_phenotyp0.98801897
64MP0001545_abnormal_hematopoietic_system0.98801897
65MP0001270_distended_abdomen0.97016720
66MP0003755_abnormal_palate_morphology0.96006094
67MP0003935_abnormal_craniofacial_develop0.95869370
68MP0003111_abnormal_nucleus_morphology0.95540712
69MP0003828_pulmonary_edema0.95388966
70MP0002115_abnormal_skeleton_extremities0.94723926
71MP0000428_abnormal_craniofacial_morphol0.94396703
72MP0001614_abnormal_blood_vessel0.94293250
73MP0000681_abnormal_thyroid_gland0.94100526
74MP0005595_abnormal_vascular_smooth0.93255961
75MP0002114_abnormal_axial_skeleton0.92675651
76MP0002089_abnormal_postnatal_growth/wei0.92427139
77MP0008932_abnormal_embryonic_tissue0.92355826
78MP0000163_abnormal_cartilage_morphology0.92251782
79MP0001915_intracranial_hemorrhage0.92062589
80MP0005076_abnormal_cell_differentiation0.92032013
81MP0008007_abnormal_cellular_replicative0.91834116
82MP0001348_abnormal_lacrimal_gland0.90007888
83MP0005193_abnormal_anterior_eye0.89822356
84MP0004134_abnormal_chest_morphology0.89415933
85MP0009333_abnormal_splenocyte_physiolog0.89402264
86MP0003448_altered_tumor_morphology0.89294258
87MP0003724_increased_susceptibility_to0.88770059
88MP0003795_abnormal_bone_structure0.88537701
89MP0002254_reproductive_system_inflammat0.86508557
90MP0000432_abnormal_head_morphology0.85300848
91MP0001661_extended_life_span0.83810678
92MP0000465_gastrointestinal_hemorrhage0.83375546
93MP0003937_abnormal_limbs/digits/tail_de0.80662192
94MP0001175_abnormal_lung_morphology0.80172426
95MP0002925_abnormal_cardiovascular_devel0.79856195
96MP0000049_abnormal_middle_ear0.79701519
97MP0001346_abnormal_lacrimal_gland0.79698605
98MP0002108_abnormal_muscle_morphology0.79425527
99MP0005367_renal/urinary_system_phenotyp0.79203560
100MP0000516_abnormal_urinary_system0.79203560
101MP0002085_abnormal_embryonic_tissue0.79125250
102MP0000613_abnormal_salivary_gland0.79088585
103MP0002405_respiratory_system_inflammati0.76042820
104MP0000013_abnormal_adipose_tissue0.75625294
105MP0000490_abnormal_crypts_of0.75102778
106MP0002419_abnormal_innate_immunity0.74597364
107MP0000249_abnormal_blood_vessel0.74511069
108MP0002111_abnormal_tail_morphology0.74413650
109MP0000467_abnormal_esophagus_morphology0.73857621
110MP0000537_abnormal_urethra_morphology0.72889826
111MP0000534_abnormal_ureter_morphology0.72504662
112MP0001286_abnormal_eye_development0.71075632
113MP0010630_abnormal_cardiac_muscle0.70575550
114MP0004133_heterotaxia0.70447924
115MP0001835_abnormal_antigen_presentation0.70035787
116MP0009785_altered_susceptibility_to0.70004437
117MP0004084_abnormal_cardiac_muscle0.69352631
118MP0010307_abnormal_tumor_latency0.69207865
119MP0003567_abnormal_fetal_cardiomyocyte0.68782643
120MP0003115_abnormal_respiratory_system0.68694191
121MP0001672_abnormal_embryogenesis/_devel0.67764644
122MP0005380_embryogenesis_phenotype0.67764644
123MP0001881_abnormal_mammary_gland0.67373203
124MP0005464_abnormal_platelet_physiology0.67102395
125MP0000751_myopathy0.66235300
126MP0000759_abnormal_skeletal_muscle0.66056071
127MP0001730_embryonic_growth_arrest0.65973598
128MP0004197_abnormal_fetal_growth/weight/0.65783922
129MP0001853_heart_inflammation0.65641407
130MP0002452_abnormal_antigen_presenting0.65348291
131MP0000538_abnormal_urinary_bladder0.65173286
132MP0003172_abnormal_lysosome_physiology0.64738051
133MP0005167_abnormal_blood-brain_barrier0.64515619
134MP0003136_yellow_coat_color0.64343082
135MP0003984_embryonic_growth_retardation0.64010366
136MP0005501_abnormal_skin_physiology0.64010248
137MP0002109_abnormal_limb_morphology0.63209260
138MP0000266_abnormal_heart_morphology0.63047137
139MP0005000_abnormal_immune_tolerance0.62597589
140MP0001849_ear_inflammation0.61982595
141MP0005164_abnormal_response_to0.61313627
142MP0005197_abnormal_uvea_morphology0.60964469

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)8.33566232
2Premature rupture of membranes (HP:0001788)6.64841658
3Vertebral compression fractures (HP:0002953)4.47605606
4Ankle contracture (HP:0006466)4.37651806
5Peritonitis (HP:0002586)4.35718282
6Aortic dissection (HP:0002647)4.30213728
7Soft skin (HP:0000977)4.09154172
8Shallow orbits (HP:0000586)4.08942934
9Biconcave vertebral bodies (HP:0004586)3.92253810
10Cerebral aneurysm (HP:0004944)3.85521897
11Aortic aneurysm (HP:0004942)3.81728613
12Cervical subluxation (HP:0003308)3.65282910
13Dilatation of the ascending aorta (HP:0005111)3.55739791
14Broad metatarsal (HP:0001783)3.53518151
15Atrophic scars (HP:0001075)3.52850525
16Bladder diverticulum (HP:0000015)3.41855979
17Abnormality of dentin (HP:0010299)3.30831602
18Nonimmune hydrops fetalis (HP:0001790)3.14727189
19* Fragile skin (HP:0001030)3.11346966
20Wormian bones (HP:0002645)3.06937868
21Broad distal phalanx of finger (HP:0009836)3.01769433
22* Blue sclerae (HP:0000592)2.95167599
23Spinal rigidity (HP:0003306)2.89682757
24Genu recurvatum (HP:0002816)2.85607413
25Mitral valve prolapse (HP:0001634)2.83427600
26Increased connective tissue (HP:0009025)2.70229716
27Spinal cord lesions (HP:0100561)2.68784313
28Syringomyelia (HP:0003396)2.68784313
29Thin bony cortex (HP:0002753)2.67088040
30Abnormality of the fetal cardiovascular system (HP:0010948)2.66861748
31Abnormal umbilical cord blood vessels (HP:0011403)2.66861748
32Single umbilical artery (HP:0001195)2.66861748
33Wrist flexion contracture (HP:0001239)2.66168686
34Type 1 muscle fiber predominance (HP:0003803)2.64447365
35Vascular tortuosity (HP:0004948)2.61774300
36Abnormality of the acetabulum (HP:0003170)2.58062354
37Abnormality of the peritoneum (HP:0002585)2.56460220
38Elbow flexion contracture (HP:0002987)2.49131634
39Short 4th metacarpal (HP:0010044)2.47811176
40Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.47811176
41Follicular hyperkeratosis (HP:0007502)2.45441898
42Arterial tortuosity (HP:0005116)2.40913182
43Osteolytic defects of the hand bones (HP:0009699)2.40753393
44Osteolytic defects of the phalanges of the hand (HP:0009771)2.40753393
45Camptodactyly of toe (HP:0001836)2.40670175
46Neonatal short-limb short stature (HP:0008921)2.39358381
47Aortic regurgitation (HP:0001659)2.38148164
48Coronal craniosynostosis (HP:0004440)2.35473823
49Increased density of long bones (HP:0006392)2.34122296
50Aneurysm (HP:0002617)2.33457343
51Abnormality of the umbilical cord (HP:0010881)2.32705528
52Abnormal delivery (HP:0001787)2.29371078
53Thrombocytosis (HP:0001894)2.28448152
54Mitral regurgitation (HP:0001653)2.28057202
55Ectopia lentis (HP:0001083)2.26970043
56Joint stiffness (HP:0001387)2.25797698
57Bowel diverticulosis (HP:0005222)2.23999491
58Hyperacusis (HP:0010780)2.23539250
59Spondylolisthesis (HP:0003302)2.19704755
60Premature skin wrinkling (HP:0100678)2.17768506
61Coxa vara (HP:0002812)2.14711061
62Radial bowing (HP:0002986)2.14607727
63Partial duplication of the phalanx of hand (HP:0009999)2.14299178
64Trismus (HP:0000211)2.13932042
65Hematochezia (HP:0002573)2.13892392
66Deviation of the hallux (HP:0010051)2.10383370
67Slender build (HP:0001533)2.09209576
68* Hyperextensible skin (HP:0000974)2.07196607
69Congenital glaucoma (HP:0001087)2.06158048
70Hallux valgus (HP:0001822)2.04964339
71Flexion contracture of toe (HP:0005830)2.04274361
72Joint contractures involving the joints of the feet (HP:0100492)2.04274361
73Long toe (HP:0010511)2.02500366
74Selective tooth agenesis (HP:0001592)2.01379135
75Abnormality of the 4th metacarpal (HP:0010012)2.00600195
76Ovoid vertebral bodies (HP:0003300)2.00229991
77Broad face (HP:0000283)1.99337058
78Abnormality of skull ossification (HP:0002703)1.98751267
79Wide anterior fontanel (HP:0000260)1.97520794
80Renal duplication (HP:0000075)1.96324805
81Flat cornea (HP:0007720)1.93811964
82* Joint laxity (HP:0001388)1.93314734
83Venous abnormality (HP:0002624)1.91575463
84Asymmetry of the thorax (HP:0001555)1.91427876
85Asymmetric septal hypertrophy (HP:0001670)1.91360481
86Aortic valve stenosis (HP:0001650)1.90774623
87Breech presentation (HP:0001623)1.90583698
88Knee flexion contracture (HP:0006380)1.90488181
89Broad long bones (HP:0005622)1.90113941
90Elevated erythrocyte sedimentation rate (HP:0003565)1.89322028
91Decreased skull ossification (HP:0004331)1.88847447
92Osteopenia (HP:0000938)1.88478777
93Bowing of the arm (HP:0006488)1.87937808
94Bowed forearm bones (HP:0003956)1.87937808
95Venous insufficiency (HP:0005293)1.87019941
96Achilles tendon contracture (HP:0001771)1.86425882
97* Delayed cranial suture closure (HP:0000270)1.86295216
98Abnormality of the distal phalanges of the toes (HP:0010182)1.85895386
99Mildly elevated creatine phosphokinase (HP:0008180)1.85745855
100Striae distensae (HP:0001065)1.85419108
101Mesangial abnormality (HP:0001966)1.85322084
102Beaking of vertebral bodies (HP:0004568)1.85060687
103Dislocated radial head (HP:0003083)1.84208036
104Flared iliac wings (HP:0002869)1.83510574
105Stridor (HP:0010307)1.82926789
106* Protruding ear (HP:0000411)1.81874734
107Abnormality of the phalanges of the hallux (HP:0010057)1.81411217
108Generalized amyotrophy (HP:0003700)1.81278621
109Mesomelia (HP:0003027)1.81156166
110Short clavicles (HP:0000894)1.80713502
111Ulnar bowing (HP:0003031)1.79811479
112Disproportionate tall stature (HP:0001519)1.78214511
113Increased variability in muscle fiber diameter (HP:0003557)1.76721311
114Abnormality of the radial head (HP:0003995)1.75640144
115Abnormality of the calcaneus (HP:0008364)1.75349339
116Slender long bone (HP:0003100)1.74589684
117Lymphangioma (HP:0100764)1.73717690
118Mitral stenosis (HP:0001718)1.73661264
119Aplasia/Hypoplasia of the clavicles (HP:0006710)1.73474644
120Abnormal ossification of hand bones (HP:0005921)1.73344880
121Redundant skin (HP:0001582)1.72766013
122Infantile muscular hypotonia (HP:0008947)1.72529204
123Buphthalmos (HP:0000557)1.72143970
124Hypoventilation (HP:0002791)1.72029789
125Femoral bowing (HP:0002980)1.71453589
126Natal tooth (HP:0000695)1.71175556
127Delayed closure of the anterior fontanelle (HP:0001476)1.70473915
128Abnormality of skeletal muscle fiber size (HP:0012084)1.70293550
129Emphysema (HP:0002097)1.68334955
130Overgrowth (HP:0001548)1.66854279
131Short nail (HP:0001799)1.65090836
132Inguinal hernia (HP:0000023)1.63994542
133Calcaneovalgus deformity (HP:0001848)1.63602886
134Platyspondyly (HP:0000926)1.63547408
135Thin skin (HP:0000963)1.63157963

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.14544439
2ERN14.05689228
3SMG13.69733955
4PKN23.51784686
5TTN2.98875881
6KDR2.97886714
7CDK122.87681330
8TGFBR22.51001963
9VRK22.49481414
10DDR22.44373519
11PIM22.27728112
12EPHA22.26536489
13LRRK22.11675967
14TESK22.07190029
15PRKD21.99278329
16TGFBR11.96074669
17NME21.92284483
18TESK11.91221732
19RPS6KA41.90780486
20PAK41.84173021
21EEF2K1.80903336
22PRKD31.80849778
23SCYL21.76317150
24EPHB21.71191164
25PDGFRA1.70526687
26WEE11.68947945
27TAF11.66438871
28FLT31.65434987
29IRAK31.65340035
30KIT1.62596708
31PTK61.61970139
32TBK11.60368015
33LATS21.58782942
34ICK1.56836174
35MAP3K101.53788278
36SIK11.52459680
37EPHA31.45912780
38STK101.44601588
39BRSK21.40547574
40PAK21.37120567
41PNCK1.34058212
42LIMK11.30252203
43MAP2K31.29838739
44CSNK1G31.28969428
45MAP4K11.27990966
46PTK21.27300735
47ZAP701.27280257
48MYLK1.26050020
49RIPK11.17812095
50TIE11.17080552
51ILK1.16866716
52PRPF4B1.16617698
53MOS1.11613552
54CDK81.09800748
55CSNK1G11.08259096
56JAK31.03859992
57BRSK11.02461012
58BLK1.00062184
59NEK90.99976717
60RPS6KA20.97815521
61HIPK20.97703569
62LATS10.96662734
63CHEK20.96293283
64MAPK150.95035936
65ERBB40.94508813
66MAP3K110.93356196
67VRK10.91798969
68CSF1R0.90732232
69FGFR10.89204259
70DMPK0.87940080
71RPS6KC10.87194866
72RPS6KL10.87194866
73TRPM70.87005798
74MAPKAPK30.85952170
75PTK2B0.84723720
76TYK20.83447554
77PDGFRB0.82268792
78TAOK20.81574409
79MAP3K80.80553226
80BMX0.80094932
81PRKG20.77859608
82GSK3A0.76786859
83MAP2K20.74188784
84SRPK10.71435525
85FGFR20.71168955
86RPS6KA60.70451302
87EPHB10.68466380
88BTK0.68049055
89CDK90.65480394
90CDK60.64833770
91AURKA0.63099352
92IKBKB0.62502680
93TEC0.62228880
94DAPK30.61825083
95FER0.59911886
96MTOR0.59336302
97ACVR1B0.59115075
98PIK3CG0.57896391
99MET0.56471791
100CSNK1G20.56396872
101BCKDK0.56313158
102RPS6KB20.56299519
103MATK0.56265720
104NTRK10.56216314
105STK30.54718248
106FGFR40.54432384
107CDC42BPA0.54400181
108DYRK1B0.53754244
109PAK10.52826847
110ROCK10.52103335
111MELK0.52101514
112MAPKAPK20.51764962
113MAPK70.48341537
114BUB10.48158511
115MAP3K30.47871481
116ROCK20.46599222
117CDK70.46407576
118JAK10.46376032
119CAMK1D0.43140442
120MAPK110.42690637
121RET0.41274827
122PIM10.40725669
123EIF2AK10.40408957
124SRC0.39477364
125HCK0.39192100
126CHUK0.38129027
127CDK40.38074835
128LCK0.37469731
129STK40.36078492
130PRKD10.35738652
131PIK3CA0.35039032
132CDK30.34615847
133AURKB0.34557581
134NEK20.33675235
135INSR0.32549712
136LYN0.32328723
137AKT20.31852235
138ITK0.31493724
139ABL20.31435926
140MAP2K10.30350366
141ADRBK10.28834809
142CAMKK20.28562473
143IGF1R0.27936752

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.65550189
2Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.54542279
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.48563043
4Focal adhesion_Homo sapiens_hsa045102.24987699
5Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.18775139
6* Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.18772383
7Malaria_Homo sapiens_hsa051442.12134288
8AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.94102325
9Proteoglycans in cancer_Homo sapiens_hsa052051.92542155
10Shigellosis_Homo sapiens_hsa051311.92329653
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.85536371
12Leishmaniasis_Homo sapiens_hsa051401.71321841
13Bladder cancer_Homo sapiens_hsa052191.71233215
14Chronic myeloid leukemia_Homo sapiens_hsa052201.70305389
15Leukocyte transendothelial migration_Homo sapiens_hsa046701.66698623
16Small cell lung cancer_Homo sapiens_hsa052221.60311753
17Amoebiasis_Homo sapiens_hsa051461.56505003
18Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.49520036
19p53 signaling pathway_Homo sapiens_hsa041151.47586577
20Viral myocarditis_Homo sapiens_hsa054161.41911176
21Adherens junction_Homo sapiens_hsa045201.41833588
22Toxoplasmosis_Homo sapiens_hsa051451.41351424
23N-Glycan biosynthesis_Homo sapiens_hsa005101.40427595
24Osteoclast differentiation_Homo sapiens_hsa043801.36438777
25Pyrimidine metabolism_Homo sapiens_hsa002401.35591139
26Apoptosis_Homo sapiens_hsa042101.32707801
27Legionellosis_Homo sapiens_hsa051341.32297820
28HTLV-I infection_Homo sapiens_hsa051661.31219388
29TGF-beta signaling pathway_Homo sapiens_hsa043501.30717727
30MicroRNAs in cancer_Homo sapiens_hsa052061.30119483
31Lysosome_Homo sapiens_hsa041421.28741818
32Wnt signaling pathway_Homo sapiens_hsa043101.26970095
33Nucleotide excision repair_Homo sapiens_hsa034201.26794983
34Ribosome_Homo sapiens_hsa030101.25725048
35Protein digestion and absorption_Homo sapiens_hsa049741.24844411
36Platelet activation_Homo sapiens_hsa046111.23436375
37Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.22302075
38PI3K-Akt signaling pathway_Homo sapiens_hsa041511.20954991
39Other glycan degradation_Homo sapiens_hsa005111.18170807
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.18093415
41Caffeine metabolism_Homo sapiens_hsa002321.17703929
42Pancreatic cancer_Homo sapiens_hsa052121.16526578
43Selenocompound metabolism_Homo sapiens_hsa004501.16188618
44Pertussis_Homo sapiens_hsa051331.14302019
45TNF signaling pathway_Homo sapiens_hsa046681.13256390
46Acute myeloid leukemia_Homo sapiens_hsa052211.12991174
47Antigen processing and presentation_Homo sapiens_hsa046121.11449675
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11292956
49Thyroid cancer_Homo sapiens_hsa052161.09594819
50RNA polymerase_Homo sapiens_hsa030201.06713526
51Salmonella infection_Homo sapiens_hsa051321.06219414
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.06182436
53Regulation of actin cytoskeleton_Homo sapiens_hsa048101.05417404
54Hematopoietic cell lineage_Homo sapiens_hsa046401.05409237
55Hepatitis B_Homo sapiens_hsa051611.02744775
56Basal cell carcinoma_Homo sapiens_hsa052171.00138223
57Hippo signaling pathway_Homo sapiens_hsa043900.97581893
58B cell receptor signaling pathway_Homo sapiens_hsa046620.97302310
59Dilated cardiomyopathy_Homo sapiens_hsa054140.97215038
60Cell cycle_Homo sapiens_hsa041100.96209424
61Pentose phosphate pathway_Homo sapiens_hsa000300.94918387
62Measles_Homo sapiens_hsa051620.94130505
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93049065
64Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92969349
65Pathways in cancer_Homo sapiens_hsa052000.92332408
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.92211858
67Sulfur metabolism_Homo sapiens_hsa009200.90744716
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89497334
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.89059969
70Phagosome_Homo sapiens_hsa041450.88682579
71Melanoma_Homo sapiens_hsa052180.88603548
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.88203385
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87979130
74HIF-1 signaling pathway_Homo sapiens_hsa040660.86718900
75Viral carcinogenesis_Homo sapiens_hsa052030.86283455
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.85262492
77Spliceosome_Homo sapiens_hsa030400.84820138
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83992290
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.83646953
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83115123
81Staphylococcus aureus infection_Homo sapiens_hsa051500.82750018
82Prion diseases_Homo sapiens_hsa050200.81738791
83Rap1 signaling pathway_Homo sapiens_hsa040150.80937348
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79384212
85DNA replication_Homo sapiens_hsa030300.79108249
86Tuberculosis_Homo sapiens_hsa051520.78922944
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77677502
88Colorectal cancer_Homo sapiens_hsa052100.76674542
89VEGF signaling pathway_Homo sapiens_hsa043700.76331890
90Notch signaling pathway_Homo sapiens_hsa043300.71825777
91Herpes simplex infection_Homo sapiens_hsa051680.71592170
92Melanogenesis_Homo sapiens_hsa049160.70821255
93Base excision repair_Homo sapiens_hsa034100.69262072
94RNA transport_Homo sapiens_hsa030130.68848330
95Prostate cancer_Homo sapiens_hsa052150.67405023
96Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.65893797
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.65893477
98Renin-angiotensin system_Homo sapiens_hsa046140.65705463
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65697515
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64363530
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62921639
102Biosynthesis of amino acids_Homo sapiens_hsa012300.62519134
103Sulfur relay system_Homo sapiens_hsa041220.60691302
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60474332
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.59414396
106Lysine degradation_Homo sapiens_hsa003100.58915523
107Endocytosis_Homo sapiens_hsa041440.58276614
108Insulin resistance_Homo sapiens_hsa049310.57964558
109Galactose metabolism_Homo sapiens_hsa000520.57291517
110Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56590788
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54206626
112Influenza A_Homo sapiens_hsa051640.53956546
113Fanconi anemia pathway_Homo sapiens_hsa034600.53953908
114Hedgehog signaling pathway_Homo sapiens_hsa043400.53656924
115Folate biosynthesis_Homo sapiens_hsa007900.52345342
116Epstein-Barr virus infection_Homo sapiens_hsa051690.48945901
117Glioma_Homo sapiens_hsa052140.48533685
118Renal cell carcinoma_Homo sapiens_hsa052110.48156322
119Vibrio cholerae infection_Homo sapiens_hsa051100.47260933
120One carbon pool by folate_Homo sapiens_hsa006700.46942150
121Non-small cell lung cancer_Homo sapiens_hsa052230.46705548
1222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46326722
123Axon guidance_Homo sapiens_hsa043600.44414362
124Homologous recombination_Homo sapiens_hsa034400.44164815
125Fatty acid elongation_Homo sapiens_hsa000620.42048914
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40485512
127Sphingolipid metabolism_Homo sapiens_hsa006000.39692489
128Mismatch repair_Homo sapiens_hsa034300.39357589
129Endometrial cancer_Homo sapiens_hsa052130.39037650
130Basal transcription factors_Homo sapiens_hsa030220.39012831
131Purine metabolism_Homo sapiens_hsa002300.35977616
132mRNA surveillance pathway_Homo sapiens_hsa030150.35853331
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35470127
134mTOR signaling pathway_Homo sapiens_hsa041500.33785047
135Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33121518
136Non-homologous end-joining_Homo sapiens_hsa034500.32872161
137Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31821265
138Vitamin B6 metabolism_Homo sapiens_hsa007500.30983982

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