CHST15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Chondroitin sulfate (CS) is a glycosaminoglycan which is an important structural component of the extracellular matrix and which links to proteins to form proteoglycans. Chondroitin sulfate E (CS-E) is an isomer of chondroitin sulfate in which the C-4 and C-6 hydroxyl groups are sulfated. This gene encodes a type II transmembrane glycoprotein that acts as a sulfotransferase to transfer sulfate to the C-6 hydroxal group of chondroitin sulfate. This gene has also been identified as being co-expressed with RAG1 in B-cells and as potentially acting as a B-cell surface signaling receptor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.87030368
2positive regulation by organism of defense response of other organism involved in symbiotic interact5.87030368
3modulation by symbiont of host immune response (GO:0052553)5.87030368
4positive regulation by symbiont of host defense response (GO:0052509)5.87030368
5modulation by symbiont of host defense response (GO:0052031)5.87030368
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.87030368
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.42958977
8negative regulation of cell killing (GO:0031342)5.42958977
9detection of molecule of bacterial origin (GO:0032490)5.35401166
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.29379557
11macrophage activation involved in immune response (GO:0002281)5.10550979
12positive regulation of gamma-delta T cell activation (GO:0046645)4.90628265
13neutrophil activation involved in immune response (GO:0002283)4.85984236
14response to peptidoglycan (GO:0032494)4.84348780
15detection of other organism (GO:0098543)4.81819028
16locomotory exploration behavior (GO:0035641)4.69812758
17lymph vessel development (GO:0001945)4.66354496
18detection of external biotic stimulus (GO:0098581)4.62758963
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.51646920
20positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.46454248
21cellular extravasation (GO:0045123)4.41237298
22antigen processing and presentation of endogenous antigen (GO:0019883)4.40314951
23negative regulation of interleukin-12 production (GO:0032695)4.39267189
24detection of bacterium (GO:0016045)4.36723482
25regulation of interferon-beta biosynthetic process (GO:0045357)4.23219972
26antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.06554374
27detection of biotic stimulus (GO:0009595)4.03945572
28microglial cell activation (GO:0001774)3.94907096
29macrophage activation (GO:0042116)3.92827828
30response to host immune response (GO:0052572)3.91727956
31response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.91727956
32neutrophil activation (GO:0042119)3.85885801
33regulation of B cell receptor signaling pathway (GO:0050855)3.81821295
34G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.77946549
35response to host (GO:0075136)3.73216325
36response to host defenses (GO:0052200)3.73216325
37response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.73216325
38regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.73205464
39leukocyte migration involved in inflammatory response (GO:0002523)3.70019624
40positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.68540062
41respiratory burst (GO:0045730)3.68053134
42synaptic vesicle maturation (GO:0016188)3.66408092
43granulocyte activation (GO:0036230)3.64740467
44regulation of synapse structural plasticity (GO:0051823)3.62706167
45regulation of glutamate receptor signaling pathway (GO:1900449)3.57145956
46leukocyte aggregation (GO:0070486)3.56834548
47negative regulation of lymphocyte mediated immunity (GO:0002707)3.55561277
48neutrophil mediated immunity (GO:0002446)3.54884041
49regulation of gamma-delta T cell activation (GO:0046643)3.52975253
50regulation of mast cell degranulation (GO:0043304)3.50057208
51exploration behavior (GO:0035640)3.43751161
52myeloid cell activation involved in immune response (GO:0002275)3.43735322
53production of molecular mediator involved in inflammatory response (GO:0002532)3.43019121
54immunoglobulin mediated immune response (GO:0016064)3.41796197
55regulation of myeloid leukocyte mediated immunity (GO:0002886)3.39715469
56germinal center formation (GO:0002467)3.38091178
57positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.37745344
58regulation of dendritic spine morphogenesis (GO:0061001)3.37352187
59regulation of T-helper 2 cell differentiation (GO:0045628)3.35917237
60lipopolysaccharide-mediated signaling pathway (GO:0031663)3.35517232
61positive regulation of cellular amide metabolic process (GO:0034250)3.35147671
62positive regulation of mast cell activation (GO:0033005)3.29858012
63regulation of leukocyte degranulation (GO:0043300)3.29177410
64layer formation in cerebral cortex (GO:0021819)3.27736667
65positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.25632257
66regulation of long-term neuronal synaptic plasticity (GO:0048169)3.25608783
67response to interleukin-15 (GO:0070672)3.22553244
68regulation of mast cell activation involved in immune response (GO:0033006)3.22039399
69negative regulation of leukocyte mediated immunity (GO:0002704)3.21363891
70response to muramyl dipeptide (GO:0032495)3.21228815
71vocalization behavior (GO:0071625)3.19104827
72regulation of short-term neuronal synaptic plasticity (GO:0048172)3.14841484
73gamma-aminobutyric acid transport (GO:0015812)3.07672654
74activation of protein kinase A activity (GO:0034199)3.06351595
75vascular endothelial growth factor signaling pathway (GO:0038084)3.06081318
76positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.04977384
77regulation of neuronal synaptic plasticity (GO:0048168)3.04650650
78membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.04101032
79cellular response to type I interferon (GO:0071357)3.03969164
80type I interferon signaling pathway (GO:0060337)3.03969164
81response to type I interferon (GO:0034340)3.01622504
82ionotropic glutamate receptor signaling pathway (GO:0035235)3.01372262
83negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.00015950
84regulation of mast cell activation (GO:0033003)2.99269366
85regulation of Rap GTPase activity (GO:0032317)2.99266071
86sodium ion export (GO:0071436)2.97973968
87synaptic vesicle docking involved in exocytosis (GO:0016081)2.97810574
88negative regulation of T cell mediated immunity (GO:0002710)2.97764779
89regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.97353373
90endothelial cell chemotaxis (GO:0035767)2.94654215
91positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.93958716
92defense response to protozoan (GO:0042832)2.93737592
93myeloid leukocyte mediated immunity (GO:0002444)2.93563455
94peptidyl-tyrosine autophosphorylation (GO:0038083)2.92462196
95antigen processing and presentation via MHC class Ib (GO:0002475)2.92362767
96positive regulation of interferon-alpha production (GO:0032727)2.92241010
97regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.91970927
98positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.91515578
99regulation of T cell tolerance induction (GO:0002664)2.87355379
100positive regulation of mast cell degranulation (GO:0043306)2.86748481
101positive regulation of mast cell activation involved in immune response (GO:0033008)2.86748481
102dendritic spine morphogenesis (GO:0060997)2.85594963
103cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.85012827
104regulation of tolerance induction (GO:0002643)2.84951180
105regulation of regulated secretory pathway (GO:1903305)2.84604146
106regulation of gamma-delta T cell differentiation (GO:0045586)2.84042930
107negative regulation of cytokine production involved in immune response (GO:0002719)2.83811393
108negative regulation of cytosolic calcium ion concentration (GO:0051481)2.83373831
109cellular potassium ion homeostasis (GO:0030007)2.82949013
110myeloid leukocyte activation (GO:0002274)2.82193467
111neurotransmitter-gated ion channel clustering (GO:0072578)2.81490510
112T-helper 1 type immune response (GO:0042088)2.81194400
113regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.81055937
114regulation of interferon-alpha production (GO:0032647)2.78674178
115synaptic vesicle exocytosis (GO:0016079)2.77414582
116neutrophil chemotaxis (GO:0030593)2.76962653
117negative regulation of dendrite morphogenesis (GO:0050774)2.76912309
118regulation of excitatory postsynaptic membrane potential (GO:0060079)2.76443366
119interferon-gamma-mediated signaling pathway (GO:0060333)2.76286930
120regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.76263116
121negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.76146126
122adenosine receptor signaling pathway (GO:0001973)2.76143857
123regulation of synaptic vesicle exocytosis (GO:2000300)2.76010247
124negative regulation of dendrite development (GO:2000171)2.75517751
125regulation of dendritic cell antigen processing and presentation (GO:0002604)2.74512273
126negative regulation of toll-like receptor signaling pathway (GO:0034122)2.74328270
127negative regulation of erythrocyte differentiation (GO:0045647)2.74320865
128positive regulation of Cdc42 GTPase activity (GO:0043089)2.72835458
129positive regulation of leukocyte degranulation (GO:0043302)2.72004427
130positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.71372429
131positive regulation of toll-like receptor signaling pathway (GO:0034123)2.70641259
132proline transport (GO:0015824)2.70224335
133dendritic cell migration (GO:0036336)2.69394877
134neutrophil migration (GO:1990266)2.69392178
135negative regulation of type 2 immune response (GO:0002829)2.68296201
136cellular response to interleukin-15 (GO:0071350)2.66955247
137negative regulation of vascular permeability (GO:0043116)2.66805232
138dendritic cell chemotaxis (GO:0002407)2.66022750
139regulation of synaptic plasticity (GO:0048167)2.65632215
140regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.65373246
141response to protozoan (GO:0001562)2.63792120
142regulation of dendritic spine development (GO:0060998)2.63161196
143potassium ion import (GO:0010107)2.61856294
144negative regulation of synaptic transmission, GABAergic (GO:0032229)2.61180593
145adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.60919391
146regulation of macrophage cytokine production (GO:0010935)2.60161094
147glutamate receptor signaling pathway (GO:0007215)2.59392035
148cAMP biosynthetic process (GO:0006171)2.59249986
149positive regulation of synapse maturation (GO:0090129)2.58739856
150neurotransmitter secretion (GO:0007269)2.56284799
151glutamate secretion (GO:0014047)2.55675153
152regulation of synaptic transmission, glutamatergic (GO:0051966)2.55613114
153long-term synaptic potentiation (GO:0060291)2.54744028
154positive regulation of fibroblast migration (GO:0010763)2.54633710
155dopamine receptor signaling pathway (GO:0007212)2.53369438
156membrane depolarization during action potential (GO:0086010)2.53229572
157positive regulation of Rap GTPase activity (GO:0032854)2.53153585
158positive regulation of vesicle fusion (GO:0031340)2.51271346
159neuromuscular process controlling balance (GO:0050885)2.50461646
160long term synaptic depression (GO:0060292)2.50122672
161protein localization to synapse (GO:0035418)2.48090646
162regulation of synaptic vesicle transport (GO:1902803)2.47780657
163neuronal action potential propagation (GO:0019227)2.46223742
164cerebellar Purkinje cell differentiation (GO:0021702)2.45395035
165regulation of postsynaptic membrane potential (GO:0060078)2.45270536
166cellular sodium ion homeostasis (GO:0006883)2.44854442
167positive regulation of dendritic spine morphogenesis (GO:0061003)2.43355932
168long-term memory (GO:0007616)2.42779583
169behavioral fear response (GO:0001662)2.40782443
170behavioral defense response (GO:0002209)2.40782443
171cell communication involved in cardiac conduction (GO:0086065)2.39085368
172synaptic transmission, glutamatergic (GO:0035249)2.38816986
173positive regulation of neurotransmitter secretion (GO:0001956)2.35894047
174axonal fasciculation (GO:0007413)2.34605053
175membrane depolarization (GO:0051899)2.34550206
176negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.34349792
177prepulse inhibition (GO:0060134)2.34029234
178B cell receptor signaling pathway (GO:0050853)2.30816981
179response to amphetamine (GO:0001975)2.30427153
180establishment of nucleus localization (GO:0040023)2.30212637
181neuron-neuron synaptic transmission (GO:0007270)2.29644657
182cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.29630633
183dendritic spine organization (GO:0097061)2.29166598
184regulation of ARF GTPase activity (GO:0032312)2.28759554
185cAMP metabolic process (GO:0046058)2.26087238
186regulation of ARF protein signal transduction (GO:0032012)2.25741035
187regulation of synaptic transmission, GABAergic (GO:0032228)2.25443823
188cytoskeletal anchoring at plasma membrane (GO:0007016)2.24740228
189neuron recognition (GO:0008038)2.24095700
190cell communication by electrical coupling (GO:0010644)2.23890260
191regulation of protein kinase A signaling (GO:0010738)2.23052768
192auditory behavior (GO:0031223)2.22295369
193regulation of glycogen (starch) synthase activity (GO:2000465)2.21014965
194innervation (GO:0060384)2.20067357
195vesicle transport along microtubule (GO:0047496)2.18658342
196stress fiber assembly (GO:0043149)2.18195703
197cAMP catabolic process (GO:0006198)2.17517252
198neuron projection extension involved in neuron projection guidance (GO:1902284)2.16980871

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.60192623
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.37297006
3EZH2_22144423_ChIP-Seq_EOC_Human3.82401459
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.69349349
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.32065177
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.20587423
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.15953280
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.96365328
9MYB_21317192_ChIP-Seq_ERMYB_Mouse2.92134350
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.70184875
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.67395751
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.66443057
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.62300298
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.62300298
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.59969814
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.45866258
17* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.44604522
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.43104303
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.39536606
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37794488
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37625762
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.30880998
23VDR_24763502_ChIP-Seq_THP-1_Human2.30500936
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.26291064
25VDR_21846776_ChIP-Seq_THP-1_Human2.21327310
26MTF2_20144788_ChIP-Seq_MESCs_Mouse2.18524930
27BRD4_27068464_Chip-Seq_AML-cells_Mouse2.16587065
28SPI1_23547873_ChIP-Seq_NB4_Human2.15621808
29* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.13945240
30DROSHA_22980978_ChIP-Seq_HELA_Human2.12238532
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.12072901
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.07797016
33EZH2_27304074_Chip-Seq_ESCs_Mouse2.02789939
34IKZF1_21737484_ChIP-ChIP_HCT116_Human2.00677155
35* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.96163813
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.95751792
37* RARB_27405468_Chip-Seq_BRAIN_Mouse1.94807362
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.94781216
39* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.93893284
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.93407306
41MAF_26560356_Chip-Seq_TH1_Human1.90409163
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87738481
43STAT4_19710469_ChIP-ChIP_TH1__Mouse1.86849507
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.86437762
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.86345880
46* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.85650876
47STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.83715316
48SCL_19346495_ChIP-Seq_HPC-7_Human1.81490581
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.77798981
50MYC_22102868_ChIP-Seq_BL_Human1.77283103
51GBX2_23144817_ChIP-Seq_PC3_Human1.75885905
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69889581
53MYB_26560356_Chip-Seq_TH2_Human1.64025476
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63637110
55WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.62222900
56GATA1_19941827_ChIP-Seq_MEL_Mouse1.61654895
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58426550
58UTX_26944678_Chip-Seq_JUKART_Human1.57751639
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.53894699
60KDM2B_26808549_Chip-Seq_K562_Human1.53590851
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.53305261
62MYB_26560356_Chip-Seq_TH1_Human1.50839303
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.49759304
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47758181
65STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46132743
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45440651
67MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.44738753
68PU_27001747_Chip-Seq_BMDM_Mouse1.42212476
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42106615
70ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.41824171
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41744055
72AR_21572438_ChIP-Seq_LNCaP_Human1.41644914
73DNAJC2_21179169_ChIP-ChIP_NT2_Human1.37425669
74* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.36426663
75RXR_22108803_ChIP-Seq_LS180_Human1.36145800
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35755319
77TP63_17297297_ChIP-ChIP_HaCaT_Human1.33227644
78CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32406549
79PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31125705
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27794347
81LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27284947
82KDM2B_26808549_Chip-Seq_DND41_Human1.27249157
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26003158
84RING1B_27294783_Chip-Seq_ESCs_Mouse1.25727605
85AHR_22903824_ChIP-Seq_MCF-7_Human1.24946761
86ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24691002
87TRIM28_21343339_ChIP-Seq_HEK293_Human1.24690213
88MAF_26560356_Chip-Seq_TH2_Human1.24682591
89GATA3_27048872_Chip-Seq_THYMUS_Human1.24485860
90KDM2B_26808549_Chip-Seq_JURKAT_Human1.23900365
91PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22774298
92TP53_16413492_ChIP-PET_HCT116_Human1.22434187
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22103735
94REST_21632747_ChIP-Seq_MESCs_Mouse1.21727852
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.20451206
96GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20273985
97ESR1_20079471_ChIP-ChIP_T-47D_Human1.19090353
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17901093
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16617802
100ERG_21242973_ChIP-ChIP_JURKAT_Human1.16549823
101CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16418141
102CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16371453
103ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15959729
104FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.15753202
105NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15097081
106PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15052814
107GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14364704
108GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14121071
109EP300_21415370_ChIP-Seq_HL-1_Mouse1.13553365
110ESR2_21235772_ChIP-Seq_MCF-7_Human1.13384163
111DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12858867
112TP53_20018659_ChIP-ChIP_R1E_Mouse1.12253091
113EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11959791
114RING1B_27294783_Chip-Seq_NPCs_Mouse1.11348084
115SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10231516
116BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09291546
117RXR_22158963_ChIP-Seq_LIVER_Mouse1.08642603
118EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08609526
119ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08218510
120PPARA_22158963_ChIP-Seq_LIVER_Mouse1.07285132
121RUNX_20019798_ChIP-Seq_JUKART_Human1.06245259
122RACK7_27058665_Chip-Seq_MCF-7_Human1.05800560
123GATA2_21666600_ChIP-Seq_HMVEC_Human1.05661309
124STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05602161
125ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.04002648
126GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03561035
127SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03381629
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03192908
129RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03134473
130TCF7_22412390_ChIP-Seq_EML_Mouse1.03055276
131CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02076957
132SMAD4_21799915_ChIP-Seq_A2780_Human1.01920848
133REST_18959480_ChIP-ChIP_MESCs_Mouse1.01786949
134GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01341278
135LXR_22158963_ChIP-Seq_LIVER_Mouse1.00082803
136* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00046823
137LXR_22292898_ChIP-Seq_THP-1_Human0.99882371
138KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99616207
139SMAD3_21741376_ChIP-Seq_HESCs_Human0.98794036
140TP53_18474530_ChIP-ChIP_U2OS_Human0.98443964
141FOXO3_23340844_ChIP-Seq_DLD1_Human0.98170601
142SOX2_21211035_ChIP-Seq_LN229_Gbm0.98100478
143TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97283828
144SMAD4_21741376_ChIP-Seq_HESCs_Human0.97195970
145LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96933416
146BCAT_22108803_ChIP-Seq_LS180_Human0.96655951
147FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95505952
148CLOCK_20551151_ChIP-Seq_293T_Human0.95345899
149AR_19668381_ChIP-Seq_PC3_Human0.95324203
150TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95231415
151GATA1_19941826_ChIP-Seq_K562_Human0.94181486
152VDR_24787735_ChIP-Seq_THP-1_Human0.93676432
153AR_25329375_ChIP-Seq_VCAP_Human0.93237732
154EGR1_19374776_ChIP-ChIP_THP-1_Human0.93137837
155TCF4_18268006_ChIP-ChIP_LS174T_Human0.93043108
156CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92803832
157GATA2_19941826_ChIP-Seq_K562_Human0.92535636
158PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91189585
159GATA1_22025678_ChIP-Seq_K562_Human0.90202060
160PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90190809
161SPI1_23127762_ChIP-Seq_K562_Human0.89285074
162KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.89277331
163ELK3_25401928_ChIP-Seq_HUVEC_Human0.88923475
164SMAD3_21741376_ChIP-Seq_EPCs_Human0.88803866
165SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.88512097
166ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87158103
167KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.86806512
168STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86659131
169CDX2_19796622_ChIP-Seq_MESCs_Mouse0.85476792
170NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.85461343
171FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.84206984
172KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.84081185

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.61562935
2MP0003436_decreased_susceptibility_to4.03638831
3MP0002822_catalepsy3.59529304
4MP0003635_abnormal_synaptic_transmissio3.25103699
5MP0010368_abnormal_lymphatic_system3.17153045
6MP0003191_abnormal_cellular_cholesterol3.11013128
7MP0001968_abnormal_touch/_nociception3.08128564
8MP0001879_abnormal_lymphatic_vessel3.02484855
9MP0002419_abnormal_innate_immunity2.98967077
10MP0003880_abnormal_central_pattern2.94976664
11MP0004270_analgesia2.79767462
12MP0009785_altered_susceptibility_to2.68054014
13MP0006082_CNS_inflammation2.62126417
14MP0005025_abnormal_response_to2.60272877
15MP0008260_abnormal_autophagy2.54898199
16MP0002063_abnormal_learning/memory/cond2.47676329
17MP0005000_abnormal_immune_tolerance2.44555914
18MP0005167_abnormal_blood-brain_barrier2.41709103
19MP0005451_abnormal_body_composition2.41426946
20MP0009745_abnormal_behavioral_response2.40347642
21MP0002735_abnormal_chemical_nociception2.33859595
22MP0003172_abnormal_lysosome_physiology2.32523760
23MP0002736_abnormal_nociception_after2.26790340
24MP0001533_abnormal_skeleton_physiology2.22210500
25MP0005671_abnormal_response_to2.21910392
26MP0002909_abnormal_adrenal_gland2.21690973
27MP0002723_abnormal_immune_serum2.21460193
28MP0002452_abnormal_antigen_presenting2.20454167
29MP0004272_abnormal_basement_membrane2.20446914
30MP0004858_abnormal_nervous_system2.19362071
31MP0002148_abnormal_hypersensitivity_rea2.17436884
32MP0010234_abnormal_vibrissa_follicle2.13737738
33MP0002420_abnormal_adaptive_immunity2.09097638
34MP0001819_abnormal_immune_cell2.07324241
35MP0003303_peritoneal_inflammation2.04540884
36MP0005058_abnormal_lysosome_morphology2.02272965
37MP0005464_abnormal_platelet_physiology1.97291200
38MP0004510_myositis1.82828182
39MP0002405_respiratory_system_inflammati1.81534705
40MP0008961_abnormal_basal_metabolism1.80475092
41MP0004947_skin_inflammation1.78595553
42MP0003183_abnormal_peptide_metabolism1.76621403
43MP0002132_abnormal_respiratory_system1.73906264
44MP0002572_abnormal_emotion/affect_behav1.72763321
45MP0002064_seizures1.71952423
46MP0008874_decreased_physiological_sensi1.68497591
47MP0003828_pulmonary_edema1.68445071
48MP0000013_abnormal_adipose_tissue1.65023841
49MP0005423_abnormal_somatic_nervous1.63937520
50MP0000858_altered_metastatic_potential1.63076059
51MP0002733_abnormal_thermal_nociception1.61672006
52MP0001845_abnormal_inflammatory_respons1.61324808
53MP0001501_abnormal_sleep_pattern1.58879916
54MP0010155_abnormal_intestine_physiology1.55757155
55MP0003690_abnormal_glial_cell1.54215640
56MP0001486_abnormal_startle_reflex1.53595781
57MP0003075_altered_response_to1.52303163
58* MP0000716_abnormal_immune_system1.51101259
59MP0002998_abnormal_bone_remodeling1.50149169
60MP0009764_decreased_sensitivity_to1.49864782
61MP0002398_abnormal_bone_marrow1.44082995
62MP0008569_lethality_at_weaning1.42878294
63MP0009780_abnormal_chondrocyte_physiolo1.42786886
64MP0008469_abnormal_protein_level1.40547449
65MP0005409_darkened_coat_color1.40191507
66MP0003763_abnormal_thymus_physiology1.40180159
67MP0005623_abnormal_meninges_morphology1.39848328
68MP0002272_abnormal_nervous_system1.39159433
69MP0009333_abnormal_splenocyte_physiolog1.34401132
70MP0000465_gastrointestinal_hemorrhage1.32302090
71MP0004811_abnormal_neuron_physiology1.31996830
72MP0003879_abnormal_hair_cell1.31324018
73MP0006054_spinal_hemorrhage1.30962592
74MP0004130_abnormal_muscle_cell1.29067823
75MP0002837_dystrophic_cardiac_calcinosis1.28560961
76MP0002254_reproductive_system_inflammat1.28221097
77MP0002734_abnormal_mechanical_nocicepti1.26643315
78MP0004381_abnormal_hair_follicle1.26324859
79MP0009840_abnormal_foam_cell1.24170217
80MP0005310_abnormal_salivary_gland1.23394856
81MP0001970_abnormal_pain_threshold1.22085510
82MP0003866_abnormal_defecation1.20912080
83MP0003300_gastrointestinal_ulcer1.20623779
84MP0002722_abnormal_immune_system1.19280388
85MP0000689_abnormal_spleen_morphology1.18963686
86MP0004883_abnormal_blood_vessel1.18265615
87* MP0002429_abnormal_blood_cell1.16768817
88MP0000343_altered_response_to1.16260761
89MP0005397_hematopoietic_system_phenotyp1.14321815
90MP0001545_abnormal_hematopoietic_system1.14321815
91MP0003329_amyloid_beta_deposits1.14067959
92MP0003633_abnormal_nervous_system1.12469038
93MP0002277_abnormal_respiratory_mucosa1.10721950
94MP0003045_fibrosis1.09710776
95MP0003279_aneurysm1.09403660
96MP0003656_abnormal_erythrocyte_physiolo1.08892988
97MP0002396_abnormal_hematopoietic_system1.08561935
98MP0002184_abnormal_innervation1.08461361
99MP0002067_abnormal_sensory_capabilities1.07362273
100MP0003448_altered_tumor_morphology1.04804767
101MP0006138_congestive_heart_failure1.03059366
102MP0009278_abnormal_bone_marrow1.02653728
103MP0009046_muscle_twitch1.00740697
104MP0005076_abnormal_cell_differentiation1.00644589
105MP0003453_abnormal_keratinocyte_physiol0.99760304
106MP0008004_abnormal_stomach_pH0.99706807
107MP0003385_abnormal_body_wall0.98509511
108MP0003091_abnormal_cell_migration0.95311286
109MP0004215_abnormal_myocardial_fiber0.94283925
110MP0004085_abnormal_heartbeat0.93670504
111MP0002332_abnormal_exercise_endurance0.93646860
112MP0000703_abnormal_thymus_morphology0.92467916
113MP0000955_abnormal_spinal_cord0.92152304
114MP0000685_abnormal_immune_system0.92064098
115MP0000569_abnormal_digit_pigmentation0.91905730
116MP0000003_abnormal_adipose_tissue0.91784438
117MP0005670_abnormal_white_adipose0.89184529
118MP0005386_behavior/neurological_phenoty0.88979364
119MP0004924_abnormal_behavior0.88979364
120MP0001440_abnormal_grooming_behavior0.88674339
121MP0005390_skeleton_phenotype0.88103660
122MP0002166_altered_tumor_susceptibility0.87439650
123MP0005595_abnormal_vascular_smooth0.86739879
124MP0000534_abnormal_ureter_morphology0.83112279
125MP0000249_abnormal_blood_vessel0.82506125
126MP0001915_intracranial_hemorrhage0.81468597
127MP0005375_adipose_tissue_phenotype0.81357845
128MP0000920_abnormal_myelination0.80824714
129MP0004484_altered_response_of0.80471689
130MP0002933_joint_inflammation0.80333859
131MP0000767_abnormal_smooth_muscle0.80330978
132MP0009763_increased_sensitivity_to0.79075008
133MP0003221_abnormal_cardiomyocyte_apopto0.78696683
134MP0003705_abnormal_hypodermis_morpholog0.77683618
135MP0000778_abnormal_nervous_system0.76230654
136MP0005164_abnormal_response_to0.76055647
137MP0000751_myopathy0.75657232
138MP0003122_maternal_imprinting0.74464169
139MP0002928_abnormal_bile_duct0.72375356
140MP0003566_abnormal_cell_adhesion0.71997616
141MP0004264_abnormal_extraembryonic_tissu0.71796583
142MP0004808_abnormal_hematopoietic_stem0.71390654
143MP0005535_abnormal_body_temperature0.71227810
144MP0001790_abnormal_immune_system0.70747550
145MP0005387_immune_system_phenotype0.70747550
146MP0003787_abnormal_imprinting0.70422545
147MP0003795_abnormal_bone_structure0.69403731
148MP0002557_abnormal_social/conspecific_i0.69106578
149MP0004185_abnormal_adipocyte_glucose0.68892600
150MP0001853_heart_inflammation0.68450391
151MP0005023_abnormal_wound_healing0.67621448
152MP0002138_abnormal_hepatobiliary_system0.67141725
153MP0003724_increased_susceptibility_to0.66845525
154MP0001663_abnormal_digestive_system0.64958589
155MP0003631_nervous_system_phenotype0.64499997
156MP0010329_abnormal_lipoprotein_level0.64183062
157MP0005666_abnormal_adipose_tissue0.63836155
158MP0001851_eye_inflammation0.63343807
159MP0001800_abnormal_humoral_immune0.63302096
160MP0005187_abnormal_penis_morphology0.63249435
161MP0002925_abnormal_cardiovascular_devel0.62512098
162MP0002066_abnormal_motor_capabilities/c0.62493350
163MP0001835_abnormal_antigen_presentation0.62395606
164MP0005166_decreased_susceptibility_to0.61708375
165MP0000604_amyloidosis0.61332360
166MP0000609_abnormal_liver_physiology0.59661257
167MP0002006_tumorigenesis0.55011704
168MP0001958_emphysema0.54514313

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.04380493
2Recurrent bacterial skin infections (HP:0005406)5.53305991
3Recurrent abscess formation (HP:0002722)5.46036193
4Orchitis (HP:0100796)5.29429676
5Abnormality of macrophages (HP:0004311)5.21631434
6Myositis (HP:0100614)5.19349326
7Recurrent gram-negative bacterial infections (HP:0005420)4.99849047
8Retrobulbar optic neuritis (HP:0100654)4.96167066
9Optic neuritis (HP:0100653)4.96167066
10Focal motor seizures (HP:0011153)4.40097870
11Myokymia (HP:0002411)4.26600572
12Gastrointestinal infarctions (HP:0005244)3.86237002
13Mediastinal lymphadenopathy (HP:0100721)3.73894727
14Focal seizures (HP:0007359)3.61345801
15Stomatitis (HP:0010280)3.59808598
16Keratoconjunctivitis sicca (HP:0001097)3.59170097
17Hemiplegia (HP:0002301)3.51326214
18Recurrent skin infections (HP:0001581)3.49589727
19Gingivitis (HP:0000230)3.47559025
20Recurrent fungal infections (HP:0002841)3.39707251
21Elevated erythrocyte sedimentation rate (HP:0003565)3.33407624
22Obstructive lung disease (HP:0006536)3.30835601
23Chronic obstructive pulmonary disease (HP:0006510)3.30835601
24Meningitis (HP:0001287)3.26041446
25Abnormality of glycolipid metabolism (HP:0010969)3.24295751
26Abnormality of liposaccharide metabolism (HP:0010968)3.24295751
27Abnormality of glycosphingolipid metabolism (HP:0004343)3.24295751
28Keratoconjunctivitis (HP:0001096)3.24277125
29Peritonitis (HP:0002586)3.10913595
30Amyloidosis (HP:0011034)3.09984111
31Gingival bleeding (HP:0000225)3.09430872
32Vasculitis (HP:0002633)3.03419282
33Urticaria (HP:0001025)3.01972984
34Cerebral aneurysm (HP:0004944)2.98097493
35Asymmetry of the thorax (HP:0001555)2.93595063
36Annular pancreas (HP:0001734)2.92514303
37Agammaglobulinemia (HP:0004432)2.90206298
38Amblyopia (HP:0000646)2.84545889
39Encephalitis (HP:0002383)2.80381946
40Arterial thrombosis (HP:0004420)2.79622827
41Visual hallucinations (HP:0002367)2.79167815
42Prolonged bleeding time (HP:0003010)2.75779433
43Verrucae (HP:0200043)2.75744887
44Papilloma (HP:0012740)2.75744887
45Episodic fever (HP:0001954)2.75602704
46Increased cerebral lipofuscin (HP:0011813)2.73123657
47Papilledema (HP:0001085)2.69293170
48Pulmonary infiltrates (HP:0002113)2.69273744
49Atonic seizures (HP:0010819)2.67860095
50Hemoptysis (HP:0002105)2.66771491
51Recurrent cutaneous fungal infections (HP:0011370)2.65624402
52Chronic mucocutaneous candidiasis (HP:0002728)2.65624402
53Chest pain (HP:0100749)2.65358484
54Hyperventilation (HP:0002883)2.65011508
55T lymphocytopenia (HP:0005403)2.64800064
56Systemic lupus erythematosus (HP:0002725)2.63987423
57Abnormal delayed hypersensitivity skin test (HP:0002963)2.63855542
58Ankyloglossia (HP:0010296)2.62055063
59Pulmonary embolism (HP:0002204)2.58736931
60Hematochezia (HP:0002573)2.57359357
61Febrile seizures (HP:0002373)2.55947477
62Poor eye contact (HP:0000817)2.55571742
63Epistaxis (HP:0000421)2.54480494
64Loss of speech (HP:0002371)2.54057631
65Vertebral arch anomaly (HP:0008438)2.53686159
66Polygenic inheritance (HP:0010982)2.52899742
67Cellulitis (HP:0100658)2.52812538
68Broad metatarsal (HP:0001783)2.48933478
69Abnormality of T cell number (HP:0011839)2.48667557
70Action tremor (HP:0002345)2.47075383
71Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.46374014
72Purpura (HP:0000979)2.46320122
73Torticollis (HP:0000473)2.44655778
74Pointed chin (HP:0000307)2.43952185
75Subacute progressive viral hepatitis (HP:0006572)2.43150640
76Abnormality of the peritoneum (HP:0002585)2.41333941
77Lymphangioma (HP:0100764)2.37851467
78Impaired social interactions (HP:0000735)2.37681972
79Abnormal social behavior (HP:0012433)2.37681972
80Anorexia (HP:0002039)2.36714754
81Hypochromic microcytic anemia (HP:0004840)2.35110095
82Gangrene (HP:0100758)2.34331634
83Hypochromic anemia (HP:0001931)2.31148992
84Exotropia (HP:0000577)2.27685651
85Recurrent viral infections (HP:0004429)2.27177614
86Leukocytosis (HP:0001974)2.26206143
87Abnormality of the lower motor neuron (HP:0002366)2.26162711
88Dysostosis multiplex (HP:0000943)2.26000015
89Broad-based gait (HP:0002136)2.25048594
90Polycythemia (HP:0001901)2.24393185
91Osteomyelitis (HP:0002754)2.24082359
92Inflammation of the large intestine (HP:0002037)2.22257599
93Colitis (HP:0002583)2.21269295
94Myocardial infarction (HP:0001658)2.21059821
95Short 4th metacarpal (HP:0010044)2.19794480
96Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.19794480
97Mitral stenosis (HP:0001718)2.19463819
98Glomerulonephritis (HP:0000099)2.19389013
99Gastrointestinal inflammation (HP:0004386)2.16537538
100Abnormality of oral frenula (HP:0000190)2.15479001
101Segmental peripheral demyelination/remyelination (HP:0003481)2.12761707
102Glomerulopathy (HP:0100820)2.12064816
103Absence seizures (HP:0002121)2.11722266
104Resting tremor (HP:0002322)2.11228432
105Buphthalmos (HP:0000557)2.11219538
106Abnormality of the pleura (HP:0002103)2.11218322
107Hydroureter (HP:0000072)2.09172334
108Epileptic encephalopathy (HP:0200134)2.08949364
109Pustule (HP:0200039)2.08870723
110Stereotypic behavior (HP:0000733)2.07994251
111Abnormality of pain sensation (HP:0010832)2.07746784
112Impaired pain sensation (HP:0007328)2.07746784
113Increased neuronal autofluorescent lipopigment (HP:0002074)2.07163477
114Postural instability (HP:0002172)2.06040719
115Depression (HP:0000716)2.05888986
116Abnormality of the endocardium (HP:0004306)2.03760987
117Arterial tortuosity (HP:0005116)2.03660593
118Slow saccadic eye movements (HP:0000514)2.02939589
119Lower limb amyotrophy (HP:0007210)2.01988112
120Diplopia (HP:0000651)2.00436930
121Abnormality of binocular vision (HP:0011514)2.00436930
122Abnormality of mucopolysaccharide metabolism (HP:0011020)1.99637740
123Abnormality of polysaccharide metabolism (HP:0011012)1.99637740
124Abnormality of glycosaminoglycan metabolism (HP:0004371)1.99637740
125Increased serum ferritin (HP:0003281)1.99090042
126Truncal ataxia (HP:0002078)1.99072999
127Generalized tonic-clonic seizures (HP:0002069)1.98717269
128Sepsis (HP:0100806)1.98692214
129Viral hepatitis (HP:0006562)1.98062780
130Disinhibition (HP:0000734)1.97430899
131Increased variability in muscle fiber diameter (HP:0003557)1.97320205
132Interstitial pulmonary disease (HP:0006530)1.96708136
133Mucopolysacchariduria (HP:0008155)1.96566608
134Urinary glycosaminoglycan excretion (HP:0003541)1.96566608
135Focal dystonia (HP:0004373)1.95344152
136Dysmetric saccades (HP:0000641)1.94529268
137Joint hemorrhage (HP:0005261)1.93603827
138Palpebral edema (HP:0100540)1.93192784
139Overgrowth (HP:0001548)1.93065718
140Impaired vibration sensation in the lower limbs (HP:0002166)1.92838848
141Mitral valve prolapse (HP:0001634)1.92187683
142Craniofacial dystonia (HP:0012179)1.91256411
143Arthropathy (HP:0003040)1.90783929
144Vertigo (HP:0002321)1.89736596
145Hypoplasia of the iris (HP:0007676)1.89509387
146Follicular hyperkeratosis (HP:0007502)1.88596202
147Hemiparesis (HP:0001269)1.86948562
148Hypoventilation (HP:0002791)1.86504937
149Aqueductal stenosis (HP:0002410)1.86465932
150Spontaneous hematomas (HP:0007420)1.86368198
151Obstructive sleep apnea (HP:0002870)1.86320357
152Increased IgM level (HP:0003496)1.86209976
153Acne (HP:0001061)1.84456137
154Granulocytopenia (HP:0001913)1.84399611
155Vacuolated lymphocytes (HP:0001922)1.84214486
156Deep venous thrombosis (HP:0002625)1.83146802
157Anxiety (HP:0000739)1.82465723
158Abnormal platelet volume (HP:0011876)1.82286436
159Skin ulcer (HP:0200042)1.82267551
160Thrombophlebitis (HP:0004418)1.82097356
161Menorrhagia (HP:0000132)1.82096084
162Lower limb asymmetry (HP:0100559)1.81466470
163Abnormality of the pericardium (HP:0001697)1.80678991
164Neurofibrillary tangles (HP:0002185)1.80570770
165Vascular tortuosity (HP:0004948)1.79977898
166Aortic aneurysm (HP:0004942)1.79036428
167Pathologic fracture (HP:0002756)1.78696061
168Long eyelashes (HP:0000527)1.78510215
169Supranuclear gaze palsy (HP:0000605)1.78230650
170Abnormality of T cells (HP:0002843)1.78207031
171Hepatosplenomegaly (HP:0001433)1.77864801
172Dialeptic seizures (HP:0011146)1.76984486
173Striae distensae (HP:0001065)1.74520964
174Absent frontal sinuses (HP:0002688)1.73460147
175Scanning speech (HP:0002168)1.73438925
176Abnormality of skeletal muscle fiber size (HP:0012084)1.71362801
177Progressive cerebellar ataxia (HP:0002073)1.70952472
178Deep palmar crease (HP:0006191)1.70700222
179Aneurysm (HP:0002617)1.67379554
180Prominent supraorbital ridges (HP:0000336)1.66513929
181Visceral angiomatosis (HP:0100761)1.65046918
182Increased IgE level (HP:0003212)1.64657695
183Macroorchidism (HP:0000053)1.64558187
184Abnormality of the 4th metacarpal (HP:0010012)1.64383214
185Shallow orbits (HP:0000586)1.64004399
186Narrow palate (HP:0000189)1.63844293
187Dilatation of the ascending aorta (HP:0005111)1.62460642
188Stroke (HP:0001297)1.62442391
189Distal lower limb amyotrophy (HP:0008944)1.60332384
190Asymmetric growth (HP:0100555)1.59104420
191Urinary urgency (HP:0000012)1.58763036
192Trigonocephaly (HP:0000243)1.58723595
193Obsessive-compulsive behavior (HP:0000722)1.58450969
194Limited hip movement (HP:0008800)1.56558964

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.25695517
2RIPK44.06340155
3BLK3.27987162
4NTRK33.22340276
5MAP3K93.02415557
6MAP2K32.97324952
7IRAK42.96058082
8TIE12.81644670
9CSK2.67324512
10KDR2.55754586
11KSR22.50026115
12CAMK1G2.42070071
13PRPF4B2.29347225
14MAP3K32.15377053
15DAPK21.98738401
16SIK21.95033930
17ZAP701.93648041
18PTK2B1.84619837
19TRIB31.81727519
20MAP3K141.81130809
21MAP3K131.71783504
22RIPK11.67665717
23FES1.63273093
24MAP3K101.61285820
25MINK11.54836019
26MAP3K111.53903984
27KSR11.51847897
28JAK31.51534722
29GRK61.48889831
30TNK21.45656690
31IKBKE1.43592228
32NTRK11.38095003
33IRAK31.37491561
34TBK11.36770312
35PNCK1.33390973
36CAMK1D1.30252899
37YES11.26099470
38TGFBR21.25971624
39CAMKK11.22105947
40BTK1.21492369
41MARK21.20349483
42MAP2K41.16620705
43MAP3K21.16314580
44EPHB21.16137361
45MAP2K11.14621517
46IRAK21.11741315
47MAP3K41.10942927
48TAOK11.10033593
49LYN1.09176567
50TAOK21.08954117
51EPHA31.07755701
52RET1.06011393
53MAP3K61.05378627
54IRAK11.05176006
55DAPK11.02426322
56BMPR21.00433446
57TXK1.00083745
58CAMK10.97095244
59PAK60.97008299
60FGFR30.96835762
61PKN20.96403556
62MAP3K70.94768657
63CDK50.94680004
64PRKD30.94495775
65LRRK20.93706271
66PDGFRA0.93681601
67MAP4K10.92320204
68MAP3K120.92209916
69DMPK0.90130471
70PRKCH0.89797404
71LCK0.88908050
72PTK60.88368317
73STK100.88027812
74TAOK30.87737613
75SMG10.87082508
76JAK10.86817860
77MAP3K10.84496145
78RAF10.82720790
79CAMK40.82205992
80SIK10.81735782
81SGK30.81444212
82GRK50.80312157
83STK110.80210312
84ICK0.75821278
85ERN10.74799175
86SYK0.74226198
87MARK10.72007139
88IKBKB0.70970555
89MAP3K50.69292682
90PDK10.68916876
91MATK0.68528781
92ALK0.67567683
93NTRK20.66938696
94HCK0.65413428
95PDPK10.64789364
96SIK30.64756076
97SGK20.63339158
98MAP2K70.62928299
99STK380.62817696
100MAPK120.62153962
101DYRK1B0.61717713
102GRK70.61678638
103ITK0.60167313
104FGFR40.59748792
105MAPK130.59403409
106MOS0.58152053
107FYN0.57012347
108SGK10.55067104
109PIK3CG0.54534960
110FGFR20.52507642
111TESK20.52372388
112ARAF0.52287024
113MAPK70.52257956
114PRKCG0.51169806
115WNK10.50914275
116FGR0.49060542
117MARK30.48995246
118PLK20.48626088
119PAK30.47900767
120FER0.46874300
121HIPK20.46646898
122RPS6KA20.46628184
123TGFBR10.46115215
124CDK120.46027086
125PRKD20.44824680
126PTK20.43925495
127MAPKAPK20.43792028
128CDC42BPA0.43569946
129PDGFRB0.43427007
130PAK40.43304943
131TYK20.42638162
132JAK20.42269608
133PRKD10.42223204
134PRKCZ0.41937350
135EPHB10.41800451
136SRC0.40684926
137MAPK40.40439371
138RPS6KL10.39535686
139RPS6KC10.39535686
140NLK0.38801271
141SGK4940.36544335
142SGK2230.36544335
143MAP2K60.35954666
144CSF1R0.35567431
145KIT0.35455442
146PRKAA20.35185401
147TTN0.32930290

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.90267320
2Leishmaniasis_Homo sapiens_hsa051402.76722866
3Long-term potentiation_Homo sapiens_hsa047202.21958292
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.12543851
5Circadian entrainment_Homo sapiens_hsa047132.05582360
6Olfactory transduction_Homo sapiens_hsa047401.98805671
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.98059910
8Malaria_Homo sapiens_hsa051441.91765968
9Salivary secretion_Homo sapiens_hsa049701.91401335
10Other glycan degradation_Homo sapiens_hsa005111.77599596
11Morphine addiction_Homo sapiens_hsa050321.74752461
12Amphetamine addiction_Homo sapiens_hsa050311.74406401
13Nicotine addiction_Homo sapiens_hsa050331.74378247
14Glutamatergic synapse_Homo sapiens_hsa047241.73658811
15NOD-like receptor signaling pathway_Homo sapiens_hsa046211.72674829
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71974110
17Renin secretion_Homo sapiens_hsa049241.70912138
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.63275649
19Dopaminergic synapse_Homo sapiens_hsa047281.62875426
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.61839794
21Gastric acid secretion_Homo sapiens_hsa049711.61744544
22Acute myeloid leukemia_Homo sapiens_hsa052211.61714021
23Legionellosis_Homo sapiens_hsa051341.61245670
24Graft-versus-host disease_Homo sapiens_hsa053321.59074174
25Allograft rejection_Homo sapiens_hsa053301.56612406
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.56511059
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.56116255
28Nitrogen metabolism_Homo sapiens_hsa009101.55873520
29Cholinergic synapse_Homo sapiens_hsa047251.54370917
30B cell receptor signaling pathway_Homo sapiens_hsa046621.51918416
31Oxytocin signaling pathway_Homo sapiens_hsa049211.51093638
32Measles_Homo sapiens_hsa051621.49639689
33GABAergic synapse_Homo sapiens_hsa047271.48545311
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.48284887
35TNF signaling pathway_Homo sapiens_hsa046681.44114199
36Influenza A_Homo sapiens_hsa051641.42696212
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.41849531
38Phagosome_Homo sapiens_hsa041451.40130904
39GnRH signaling pathway_Homo sapiens_hsa049121.39479176
40Autoimmune thyroid disease_Homo sapiens_hsa053201.39115733
41Pertussis_Homo sapiens_hsa051331.37008383
42Glioma_Homo sapiens_hsa052141.36910919
43Calcium signaling pathway_Homo sapiens_hsa040201.36886024
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30809952
45Long-term depression_Homo sapiens_hsa047301.30773107
46Hematopoietic cell lineage_Homo sapiens_hsa046401.30764478
47African trypanosomiasis_Homo sapiens_hsa051431.29676415
48Lysosome_Homo sapiens_hsa041421.29210702
49Estrogen signaling pathway_Homo sapiens_hsa049151.29145453
50Gap junction_Homo sapiens_hsa045401.27121557
51cAMP signaling pathway_Homo sapiens_hsa040241.24054375
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.23517385
53VEGF signaling pathway_Homo sapiens_hsa043701.21827063
54Hepatitis C_Homo sapiens_hsa051601.19551489
55cGMP-PKG signaling pathway_Homo sapiens_hsa040221.19116413
56Complement and coagulation cascades_Homo sapiens_hsa046101.18085565
57Jak-STAT signaling pathway_Homo sapiens_hsa046301.17885665
58Antigen processing and presentation_Homo sapiens_hsa046121.17295965
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16955197
60Hepatitis B_Homo sapiens_hsa051611.16927313
61Cocaine addiction_Homo sapiens_hsa050301.16162939
62Melanogenesis_Homo sapiens_hsa049161.15395627
63Insulin secretion_Homo sapiens_hsa049111.15370360
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.14507360
65Salmonella infection_Homo sapiens_hsa051321.14423582
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13626374
67Glycosaminoglycan degradation_Homo sapiens_hsa005311.11401522
68Dorso-ventral axis formation_Homo sapiens_hsa043201.11110980
69Viral myocarditis_Homo sapiens_hsa054161.10576420
70Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10197317
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.08260989
72Phospholipase D signaling pathway_Homo sapiens_hsa040721.07926766
73Axon guidance_Homo sapiens_hsa043601.06617555
74Neurotrophin signaling pathway_Homo sapiens_hsa047221.06230847
75Rap1 signaling pathway_Homo sapiens_hsa040151.05858831
76Synaptic vesicle cycle_Homo sapiens_hsa047211.04460551
77Taste transduction_Homo sapiens_hsa047421.03482585
78Herpes simplex infection_Homo sapiens_hsa051681.03407787
79Type I diabetes mellitus_Homo sapiens_hsa049401.03292943
80Platelet activation_Homo sapiens_hsa046110.99859856
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99779871
82Apoptosis_Homo sapiens_hsa042100.97936830
83Primary immunodeficiency_Homo sapiens_hsa053400.96952890
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96828703
85Type II diabetes mellitus_Homo sapiens_hsa049300.96485339
86Rheumatoid arthritis_Homo sapiens_hsa053230.95564568
87Serotonergic synapse_Homo sapiens_hsa047260.95365197
88Shigellosis_Homo sapiens_hsa051310.92675886
89Non-small cell lung cancer_Homo sapiens_hsa052230.91855354
90Choline metabolism in cancer_Homo sapiens_hsa052310.91090482
91Notch signaling pathway_Homo sapiens_hsa043300.91076361
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.90522650
93Prolactin signaling pathway_Homo sapiens_hsa049170.89553847
94Chemokine signaling pathway_Homo sapiens_hsa040620.85129285
95Amoebiasis_Homo sapiens_hsa051460.83892513
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83448892
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82166098
98Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81608170
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81121818
100Focal adhesion_Homo sapiens_hsa045100.81046221
101Thyroid hormone synthesis_Homo sapiens_hsa049180.81014536
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.80798327
103Osteoclast differentiation_Homo sapiens_hsa043800.79127004
104HIF-1 signaling pathway_Homo sapiens_hsa040660.79092196
105ErbB signaling pathway_Homo sapiens_hsa040120.78216855
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78007821
107FoxO signaling pathway_Homo sapiens_hsa040680.76891483
108MAPK signaling pathway_Homo sapiens_hsa040100.76406147
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.76053213
110Glucagon signaling pathway_Homo sapiens_hsa049220.71329263
111Bile secretion_Homo sapiens_hsa049760.71288946
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.70746614
113Intestinal immune network for IgA production_Homo sapiens_hsa046720.70356946
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69937359
115Proteoglycans in cancer_Homo sapiens_hsa052050.69595078
116Pancreatic secretion_Homo sapiens_hsa049720.69384792
117Insulin resistance_Homo sapiens_hsa049310.68525603
118Adherens junction_Homo sapiens_hsa045200.67475614
119Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66076776
120Asthma_Homo sapiens_hsa053100.65860000
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65801047
122Ras signaling pathway_Homo sapiens_hsa040140.64726468
123Dilated cardiomyopathy_Homo sapiens_hsa054140.63600090
124ECM-receptor interaction_Homo sapiens_hsa045120.61963817
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61609315
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61369217
127Inositol phosphate metabolism_Homo sapiens_hsa005620.60170818
128Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60134506
129Endometrial cancer_Homo sapiens_hsa052130.60032393
130* Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59830591
131Chronic myeloid leukemia_Homo sapiens_hsa052200.59275949
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58282679
133mTOR signaling pathway_Homo sapiens_hsa041500.57290528
134Bladder cancer_Homo sapiens_hsa052190.56529999
135Insulin signaling pathway_Homo sapiens_hsa049100.55171744
136Prion diseases_Homo sapiens_hsa050200.54817647
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53528679
138Pancreatic cancer_Homo sapiens_hsa052120.52460448
139Toxoplasmosis_Homo sapiens_hsa051450.52235833
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52014538
141Colorectal cancer_Homo sapiens_hsa052100.51155811
142Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50867385
143Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50526442
144Wnt signaling pathway_Homo sapiens_hsa043100.50223636
145Prostate cancer_Homo sapiens_hsa052150.49681456
146Endocytosis_Homo sapiens_hsa041440.48934787
147Viral carcinogenesis_Homo sapiens_hsa052030.47714478
148Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46643396
149T cell receptor signaling pathway_Homo sapiens_hsa046600.46381066
150Pathways in cancer_Homo sapiens_hsa052000.46325389
151Tuberculosis_Homo sapiens_hsa051520.46065624
152Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46000627
153Renal cell carcinoma_Homo sapiens_hsa052110.45705607
154Thyroid cancer_Homo sapiens_hsa052160.45681118
155Epstein-Barr virus infection_Homo sapiens_hsa051690.44490356

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