CHST2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus encodes a sulfotransferase protein. The encoded enzyme catalyzes the sulfation of a nonreducing N-acetylglucosamine residue, and may play a role in biosynthesis of 6-sulfosialyl Lewis X antigen. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)5.08962358
2axon ensheathment in central nervous system (GO:0032291)5.08962358
3L-amino acid import (GO:0043092)5.08840880
4negative regulation of erythrocyte differentiation (GO:0045647)4.92872670
5neuron cell-cell adhesion (GO:0007158)4.71150072
6presynaptic membrane assembly (GO:0097105)4.44825196
7positive regulation of gamma-delta T cell activation (GO:0046645)4.39921614
8vocalization behavior (GO:0071625)4.32970635
9locomotory exploration behavior (GO:0035641)4.31671759
10amino acid import (GO:0043090)4.30125097
11cellular extravasation (GO:0045123)4.09887943
12presynaptic membrane organization (GO:0097090)4.09814579
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.07295280
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.04967259
15positive regulation by symbiont of host defense response (GO:0052509)4.01875979
16modulation by symbiont of host defense response (GO:0052031)4.01875979
17modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.01875979
18modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.01875979
19positive regulation by organism of defense response of other organism involved in symbiotic interact4.01875979
20modulation by symbiont of host immune response (GO:0052553)4.01875979
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.99629807
22negative regulation of cell killing (GO:0031342)3.99629807
23synaptic vesicle maturation (GO:0016188)3.93694628
24postsynaptic membrane organization (GO:0001941)3.89611210
25synaptic vesicle exocytosis (GO:0016079)3.83469217
26neurotransmitter-gated ion channel clustering (GO:0072578)3.79376726
27oxygen transport (GO:0015671)3.76585720
28protein localization to synapse (GO:0035418)3.74060288
29auditory behavior (GO:0031223)3.70668741
30glutamate secretion (GO:0014047)3.70484289
31negative regulation of neurotransmitter transport (GO:0051589)3.68039529
32cerebral cortex radially oriented cell migration (GO:0021799)3.65323790
33regulation of short-term neuronal synaptic plasticity (GO:0048172)3.63520220
34dendritic spine morphogenesis (GO:0060997)3.56743555
35ionotropic glutamate receptor signaling pathway (GO:0035235)3.56588106
36regulation of glutamate receptor signaling pathway (GO:1900449)3.55804011
37response to auditory stimulus (GO:0010996)3.55191084
38response to peptidoglycan (GO:0032494)3.55172155
39antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.53009760
40gas transport (GO:0015669)3.52487919
41regulation of synaptic vesicle exocytosis (GO:2000300)3.52456179
42neuronal action potential propagation (GO:0019227)3.48135810
43exploration behavior (GO:0035640)3.48028673
44synaptic transmission, glutamatergic (GO:0035249)3.47925239
45negative regulation of synaptic transmission, GABAergic (GO:0032229)3.47589902
46fatty acid elongation (GO:0030497)3.45749586
47regulation of neuronal synaptic plasticity (GO:0048168)3.43136554
48C4-dicarboxylate transport (GO:0015740)3.40496083
49glutamate receptor signaling pathway (GO:0007215)3.40494022
50antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.39544735
51neuron recognition (GO:0008038)3.39477282
52positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.38858609
53negative regulation of homotypic cell-cell adhesion (GO:0034111)3.38829127
54mechanosensory behavior (GO:0007638)3.34722467
55regulation of platelet aggregation (GO:0090330)3.34357251
56negative regulation of interleukin-12 production (GO:0032695)3.32323596
57long-term synaptic potentiation (GO:0060291)3.31205454
58antigen processing and presentation of endogenous antigen (GO:0019883)3.30711642
59regulation of synapse structural plasticity (GO:0051823)3.29779478
60macrophage activation involved in immune response (GO:0002281)3.29328999
61cerebellar granule cell differentiation (GO:0021707)3.29242571
62regulation of long-term neuronal synaptic plasticity (GO:0048169)3.29133276
63neurotransmitter uptake (GO:0001504)3.29085423
64transmission of nerve impulse (GO:0019226)3.28410671
65dendrite morphogenesis (GO:0048813)3.26531123
66axonal fasciculation (GO:0007413)3.26119135
67gamma-aminobutyric acid transport (GO:0015812)3.25497775
68neuron-neuron synaptic transmission (GO:0007270)3.21403739
69myelination (GO:0042552)3.21168433
70response to muramyl dipeptide (GO:0032495)3.17559325
71positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.16736610
72regulation of B cell receptor signaling pathway (GO:0050855)3.16255864
73leukocyte aggregation (GO:0070486)3.14142799
74layer formation in cerebral cortex (GO:0021819)3.13714268
75regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.13063906
76ensheathment of neurons (GO:0007272)3.12541745
77axon ensheathment (GO:0008366)3.12541745
78lipopolysaccharide-mediated signaling pathway (GO:0031663)3.11207029
79establishment of mitochondrion localization (GO:0051654)3.10586756
80negative regulation of neurotransmitter secretion (GO:0046929)3.10274218
81membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.09664143
82regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.09504108
83negative regulation of protein localization to cell surface (GO:2000009)3.09272598
84detection of other organism (GO:0098543)3.08438874
85erythrocyte development (GO:0048821)3.07529973
86long-chain fatty acid biosynthetic process (GO:0042759)3.05954025
87modulation by symbiont of host cellular process (GO:0044068)3.04043390
88positive regulation of synapse assembly (GO:0051965)3.02228067
89response to protozoan (GO:0001562)2.99745576
90regulation of synaptic vesicle transport (GO:1902803)2.97725832
91regulation of synaptic transmission, glutamatergic (GO:0051966)2.97706959
92signal complex assembly (GO:0007172)2.96781136
93defense response to protozoan (GO:0042832)2.96668968
94detection of bacterium (GO:0016045)2.95796825
95acidic amino acid transport (GO:0015800)2.94624081
96positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.94290300
97response to methylmercury (GO:0051597)2.92077491
98positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.91254941
99synaptic vesicle docking involved in exocytosis (GO:0016081)2.91019393
100regulation of vitamin D biosynthetic process (GO:0060556)2.90048969
101startle response (GO:0001964)2.89167224
102B cell receptor signaling pathway (GO:0050853)2.88587206
103germinal center formation (GO:0002467)2.88462022
104regulation of early endosome to late endosome transport (GO:2000641)2.88405947
105regulation of synaptic plasticity (GO:0048167)2.86973449
106positive thymic T cell selection (GO:0045059)2.86808350
107myeloid dendritic cell differentiation (GO:0043011)2.86609930
108regulation of excitatory postsynaptic membrane potential (GO:0060079)2.86426587
109regulation of mast cell degranulation (GO:0043304)2.85829483
110modulation by virus of host process (GO:0019054)2.84516721
111regulation of macrophage cytokine production (GO:0010935)2.83355125
112neurotransmitter secretion (GO:0007269)2.83193691
113synapse assembly (GO:0007416)2.82198516
114regulation of gamma-delta T cell activation (GO:0046643)2.81742669
115negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.81714652
116regulation of respiratory system process (GO:0044065)2.81312294
117cellular potassium ion homeostasis (GO:0030007)2.81140950
118positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.80909451
119positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.80208005
120G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.79277218
121L-glutamate transport (GO:0015813)2.77988043
122antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.77670236
123central nervous system projection neuron axonogenesis (GO:0021952)2.76952929
124positive regulation of Rap GTPase activity (GO:0032854)2.76809467
125negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.76561039
126adenosine receptor signaling pathway (GO:0001973)2.75745711
127response to host immune response (GO:0052572)2.75649771
128response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.75649771
129gamma-aminobutyric acid signaling pathway (GO:0007214)2.75125030
130positive regulation of macrophage cytokine production (GO:0060907)2.75062789
131regulation of interferon-beta biosynthetic process (GO:0045357)2.74440998
132regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.73871629
133long-term memory (GO:0007616)2.69944013
134regulation of postsynaptic membrane potential (GO:0060078)2.67685642
135regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.67095424
136oligodendrocyte differentiation (GO:0048709)2.66972984
137positive regulation of membrane potential (GO:0045838)2.66043445
138T-helper 1 type immune response (GO:0042088)2.65695662
139neuronal ion channel clustering (GO:0045161)2.65406403
140dendrite development (GO:0016358)2.64933739
141regulation of dendritic spine morphogenesis (GO:0061001)2.62810472
142regulation of respiratory gaseous exchange (GO:0043576)2.62464890
143negative regulation of T cell mediated immunity (GO:0002710)2.62332201
144adult walking behavior (GO:0007628)2.61975721
145protoporphyrinogen IX metabolic process (GO:0046501)2.61963562
146T cell migration (GO:0072678)2.61793560
147regulation of leukocyte degranulation (GO:0043300)2.60930940
148innervation (GO:0060384)2.60587200
149dendritic spine organization (GO:0097061)2.58859506
150neurotransmitter transport (GO:0006836)2.58602636
151cellular response to thyroid hormone stimulus (GO:0097067)2.57637510
152regulation of neurotransmitter secretion (GO:0046928)2.57616899
153learning (GO:0007612)2.57514206
154regulation of synaptic transmission, GABAergic (GO:0032228)2.57314495
155response to type I interferon (GO:0034340)2.56780508
156regulation of T cell tolerance induction (GO:0002664)2.54945783
157myeloid dendritic cell activation (GO:0001773)2.54722056
158immunoglobulin mediated immune response (GO:0016064)2.54637900
159regulation of myeloid leukocyte mediated immunity (GO:0002886)2.54223522
160cellular response to type I interferon (GO:0071357)2.52777282
161type I interferon signaling pathway (GO:0060337)2.52777282
162regulation of neurotransmitter transport (GO:0051588)2.52344576
163peripheral nervous system axon ensheathment (GO:0032292)2.52292353
164myelination in peripheral nervous system (GO:0022011)2.52292353
165cell migration in hindbrain (GO:0021535)2.51196204
166response to laminar fluid shear stress (GO:0034616)2.50973352
167negative regulation of focal adhesion assembly (GO:0051895)2.50857618
168negative regulation of cell junction assembly (GO:1901889)2.50857618
169negative regulation of adherens junction organization (GO:1903392)2.50857618
170positive regulation of synaptic transmission, GABAergic (GO:0032230)2.50674028
171positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.50277331
172NIK/NF-kappaB signaling (GO:0038061)2.49448643
173neutrophil activation involved in immune response (GO:0002283)2.48498838
174regulation of mast cell activation involved in immune response (GO:0033006)2.47880528
175positive regulation of cellular amide metabolic process (GO:0034250)2.46817477
176detection of external biotic stimulus (GO:0098581)2.43665876
177response to host (GO:0075136)2.43062845
178response to host defenses (GO:0052200)2.43062845
179response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.43062845
180granulocyte differentiation (GO:0030851)2.42640362
181positive regulation of mast cell activation (GO:0033005)2.41396255
182negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.41359327
183regulation of response to osmotic stress (GO:0047484)2.41214847
184barbed-end actin filament capping (GO:0051016)2.41114379
185regulation of T-helper 2 cell differentiation (GO:0045628)2.41022465
186protein localization to endosome (GO:0036010)2.40653907
187regulation of dendritic cell antigen processing and presentation (GO:0002604)2.40197607
188negative regulation of cytokine production involved in immune response (GO:0002719)2.39928574
189regulation of ARF protein signal transduction (GO:0032012)2.38533200
190respiratory burst (GO:0045730)2.37819077
191interferon-gamma-mediated signaling pathway (GO:0060333)2.37717239
192regulation of regulated secretory pathway (GO:1903305)2.37681057
193microglial cell activation (GO:0001774)2.36227100
194thymic T cell selection (GO:0045061)2.34429209
195hemoglobin metabolic process (GO:0020027)2.32942699
196tolerance induction (GO:0002507)2.31794973
197macrophage activation (GO:0042116)2.31262173
198negative regulation of leukocyte mediated immunity (GO:0002704)2.30482034
199stress fiber assembly (GO:0043149)2.30418168
200regulation of tolerance induction (GO:0002643)2.29870949

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.71879968
2GBX2_23144817_ChIP-Seq_PC3_Human3.56278999
3MYC_22102868_ChIP-Seq_BL_Human3.08253726
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.02285700
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.00393149
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.99664711
7VDR_21846776_ChIP-Seq_THP-1_Human2.99516391
8* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.99144069
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.89428349
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.80530748
11* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.62301537
12* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.62301537
13* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.60451530
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.57980925
15* EZH2_27304074_Chip-Seq_ESCs_Mouse2.55357505
16* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54220581
17* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53943916
18* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51292750
19* GATA1_19941826_ChIP-Seq_K562_Human2.49481866
20* EED_16625203_ChIP-ChIP_MESCs_Mouse2.48601978
21LXR_22292898_ChIP-Seq_THP-1_Human2.47084818
22AR_21572438_ChIP-Seq_LNCaP_Human2.44090720
23KDM2B_26808549_Chip-Seq_DND41_Human2.41386657
24* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.41108300
25* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37205387
26VDR_24763502_ChIP-Seq_THP-1_Human2.34824489
27TCF7_22412390_ChIP-Seq_EML_Mouse2.34475515
28SCL_19346495_ChIP-Seq_HPC-7_Human2.33480158
29BP1_19119308_ChIP-ChIP_Hs578T_Human2.32844606
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.28897463
31ELK3_25401928_ChIP-Seq_HUVEC_Human2.28681711
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.27931511
33* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26656520
34* RNF2_27304074_Chip-Seq_ESCs_Mouse2.23357043
35IRF8_22096565_ChIP-ChIP_GC-B_Human2.21236256
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.20417401
37MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.19560908
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.17687803
39TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.16297473
40SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12004368
41* EZH2_27294783_Chip-Seq_ESCs_Mouse2.10423919
42GATA1_22025678_ChIP-Seq_K562_Human2.00819401
43KDM2B_26808549_Chip-Seq_K562_Human1.99434129
44KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.98027879
45MYB_21317192_ChIP-Seq_ERMYB_Mouse1.97275418
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96553555
47MAF_26560356_Chip-Seq_TH1_Human1.95836837
48KDM2B_26808549_Chip-Seq_JURKAT_Human1.92372266
49REST_21632747_ChIP-Seq_MESCs_Mouse1.91573767
50DROSHA_22980978_ChIP-Seq_HELA_Human1.90304565
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90073778
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86338134
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.84223681
54NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83163280
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82567585
56RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.82134066
57TAF15_26573619_Chip-Seq_HEK293_Human1.80193212
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.78584422
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76799253
60BRD4_27068464_Chip-Seq_AML-cells_Mouse1.76438692
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75777227
62IRF8_27001747_Chip-Seq_BMDM_Mouse1.75470606
63* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.75114199
64UTX_26944678_Chip-Seq_JUKART_Human1.74137046
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73336832
66STAT4_19710469_ChIP-ChIP_TH1__Mouse1.72290576
67TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.70424269
68* SPI1_23127762_ChIP-Seq_K562_Human1.70074098
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.69523038
70GATA1_19941827_ChIP-Seq_MEL_Mouse1.69346871
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.68950179
72RUNX1_22412390_ChIP-Seq_EML_Mouse1.68497891
73RARG_19884340_ChIP-ChIP_MEFs_Mouse1.68250730
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67727697
75* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.67630661
76RUNX_20019798_ChIP-Seq_JUKART_Human1.66794897
77CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65506501
78RARB_27405468_Chip-Seq_BRAIN_Mouse1.64958026
79P300_19829295_ChIP-Seq_ESCs_Human1.62877630
80MAF_26560356_Chip-Seq_TH2_Human1.61558279
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.56352056
82STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.55824422
83IRF8_21731497_ChIP-ChIP_J774_Mouse1.55467195
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.55279334
85EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54662039
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.53688687
87SMAD4_21799915_ChIP-Seq_A2780_Human1.51755984
88PIAS1_25552417_ChIP-Seq_VCAP_Human1.51182325
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50657368
90STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50118107
91CTCF_27219007_Chip-Seq_ERYTHROID_Human1.47182234
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45848101
93SMAD_19615063_ChIP-ChIP_OVARY_Human1.45695117
94REST_18959480_ChIP-ChIP_MESCs_Mouse1.44925782
95CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44834561
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44131834
97* GATA2_19941826_ChIP-Seq_K562_Human1.43903439
98FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.43471036
99GATA1_22383799_ChIP-Seq_G1ME_Mouse1.41620696
100SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.40429976
101* NCOR1_26117541_ChIP-Seq_K562_Human1.39176985
102POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35467338
103NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34507810
104IKZF1_21737484_ChIP-ChIP_HCT116_Human1.34193100
105EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.32536860
106* SA1_27219007_Chip-Seq_ERYTHROID_Human1.32524618
107* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32406914
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.31471639
109RACK7_27058665_Chip-Seq_MCF-7_Human1.30967223
110MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30221229
111IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.29911720
112SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27695895
113CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.27293973
114BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26364171
115ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26246853
116* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26042821
117STAT3_23295773_ChIP-Seq_U87_Human1.26003431
118FUS_26573619_Chip-Seq_HEK293_Human1.25161522
119RING1B_27294783_Chip-Seq_ESCs_Mouse1.23916125
120AR_25329375_ChIP-Seq_VCAP_Human1.23625929
121GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23385376
122* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.23129097
123DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22910268
124RING1B_27294783_Chip-Seq_NPCs_Mouse1.22552537
125AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22291782
126* ERG_21242973_ChIP-ChIP_JURKAT_Human1.18632782
127NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18259230
128NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18109467
129ARNT_22903824_ChIP-Seq_MCF-7_Human1.17719151
130PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17416599
131ER_23166858_ChIP-Seq_MCF-7_Human1.17386276
132MYB_26560356_Chip-Seq_TH1_Human1.16845542
133TP53_18474530_ChIP-ChIP_U2OS_Human1.16446279
134NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.16155766
135ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15783463
136SOX2_21211035_ChIP-Seq_LN229_Gbm1.15225394
137IGF1R_20145208_ChIP-Seq_DFB_Human1.15178553
138RNF2_27304074_Chip-Seq_NSC_Mouse1.14871942
139FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.14386777
140TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13633134
141* PRDM14_20953172_ChIP-Seq_ESCs_Human1.12583192
142WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12582791
143* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12214680
144UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10905349
145UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10775212
146TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.10462769
147EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10443005
148SPI1_23547873_ChIP-Seq_NB4_Human1.08568699
149VDR_24787735_ChIP-Seq_THP-1_Human1.07739022
150AHR_22903824_ChIP-Seq_MCF-7_Human1.07680983
151GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07566338
152GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07319083
153MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06945168
154AR_19668381_ChIP-Seq_PC3_Human1.06247792
155TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06155852
156* TCF4_23295773_ChIP-Seq_U87_Human1.05932890
157POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04982977
158TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04982977
159HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04581504
160RXR_22108803_ChIP-Seq_LS180_Human1.03580454
161NANOG_18555785_Chip-Seq_ESCs_Mouse1.03503445
162SMC1_22415368_ChIP-Seq_MEFs_Mouse1.03441870
163ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02678419
164CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01321761
165MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01301092
166* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99755015
167P68_20966046_ChIP-Seq_HELA_Human0.99415869
168BCOR_27268052_Chip-Seq_Bcells_Human0.99330021
169TP53_16413492_ChIP-PET_HCT116_Human0.99264893
170PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98868211
171CREB1_26743006_Chip-Seq_LNCaP_Human0.98854647
172RUNX2_22187159_ChIP-Seq_PCA_Human0.98493848
173PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97806844
174CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97748221
175CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97608552
176SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97301851
177Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97024434
178BCL6_27268052_Chip-Seq_Bcells_Human0.96942000
179SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.96890010
180P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96539351
181JUN_21703547_ChIP-Seq_K562_Human0.96486767
182* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95989417
183P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95977462
184E2F1_18555785_Chip-Seq_ESCs_Mouse0.95722134
185CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95039174
186EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94555985
187EP300_21415370_ChIP-Seq_HL-1_Mouse0.94061004
188LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94022271
189* MYB_26560356_Chip-Seq_TH2_Human0.93895611
190SMAD3_21741376_ChIP-Seq_ESCs_Human0.93261245
191WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93212691
192MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92533069
193SMC4_20622854_ChIP-Seq_HELA_Human0.92518354
194SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92398489
195SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.91620212
196GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91563297

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation5.04559744
2MP0004859_abnormal_synaptic_plasticity4.78825381
3MP0003880_abnormal_central_pattern3.98364237
4MP0003436_decreased_susceptibility_to3.42337326
5MP0004270_analgesia3.33692247
6MP0003635_abnormal_synaptic_transmissio3.25158843
7MP0009278_abnormal_bone_marrow3.06122933
8MP0005423_abnormal_somatic_nervous2.82139333
9MP0003656_abnormal_erythrocyte_physiolo2.79061072
10MP0001486_abnormal_startle_reflex2.78454800
11MP0009745_abnormal_behavioral_response2.77560017
12MP0002063_abnormal_learning/memory/cond2.74717710
13MP0002064_seizures2.68155148
14MP0000778_abnormal_nervous_system2.56864744
15MP0003724_increased_susceptibility_to2.54760983
16MP0004510_myositis2.54746597
17MP0000685_abnormal_immune_system2.54497633
18MP0001790_abnormal_immune_system2.50833379
19MP0005387_immune_system_phenotype2.50833379
20MP0002272_abnormal_nervous_system2.43681487
21MP0002572_abnormal_emotion/affect_behav2.41049728
22MP0008438_abnormal_cutaneous_collagen2.39797629
23MP0005671_abnormal_response_to2.38369901
24MP0009046_muscle_twitch2.37246200
25MP0003300_gastrointestinal_ulcer2.35695733
26MP0002734_abnormal_mechanical_nocicepti2.33775512
27MP0005000_abnormal_immune_tolerance2.33272400
28MP0004885_abnormal_endolymph2.32855045
29MP0001835_abnormal_antigen_presentation2.32746978
30MP0005025_abnormal_response_to2.30607204
31MP0001968_abnormal_touch/_nociception2.26677190
32MP0001800_abnormal_humoral_immune2.26307457
33MP0003705_abnormal_hypodermis_morpholog2.26224710
34MP0009785_altered_susceptibility_to2.23908249
35MP0002419_abnormal_innate_immunity2.23840402
36MP0000920_abnormal_myelination2.14698835
37MP0004858_abnormal_nervous_system2.08305257
38MP0001545_abnormal_hematopoietic_system2.02023706
39MP0005397_hematopoietic_system_phenotyp2.02023706
40MP0002723_abnormal_immune_serum2.00742473
41MP0002452_abnormal_antigen_presenting2.00610601
42MP0002148_abnormal_hypersensitivity_rea1.97128199
43MP0004947_skin_inflammation1.96663112
44MP0002736_abnormal_nociception_after1.95503236
45MP0001533_abnormal_skeleton_physiology1.93297641
46MP0003329_amyloid_beta_deposits1.91687530
47* MP0002420_abnormal_adaptive_immunity1.91588649
48MP0002735_abnormal_chemical_nociception1.91170313
49MP0008569_lethality_at_weaning1.90419429
50* MP0001819_abnormal_immune_cell1.89927892
51MP0005646_abnormal_pituitary_gland1.89219393
52MP0009780_abnormal_chondrocyte_physiolo1.84521928
53MP0005464_abnormal_platelet_physiology1.81855619
54MP0002067_abnormal_sensory_capabilities1.81714949
55MP0003075_altered_response_to1.81405508
56MP0003690_abnormal_glial_cell1.78567681
57MP0009764_decreased_sensitivity_to1.76896026
58MP0005409_darkened_coat_color1.75953113
59MP0001905_abnormal_dopamine_level1.75711145
60MP0001529_abnormal_vocalization1.74980502
61MP0001440_abnormal_grooming_behavior1.74737630
62MP0009333_abnormal_splenocyte_physiolog1.74611138
63MP0002398_abnormal_bone_marrow1.74254589
64MP0006082_CNS_inflammation1.74233635
65MP0005451_abnormal_body_composition1.74023303
66MP0002405_respiratory_system_inflammati1.70150979
67MP0000955_abnormal_spinal_cord1.69097898
68MP0001970_abnormal_pain_threshold1.69004901
69MP0005645_abnormal_hypothalamus_physiol1.68978502
70MP0008260_abnormal_autophagy1.68761257
71MP0004742_abnormal_vestibular_system1.68451875
72MP0003279_aneurysm1.68060623
73MP0002733_abnormal_thermal_nociception1.67462008
74MP0002822_catalepsy1.67424256
75MP0003091_abnormal_cell_migration1.66582240
76MP0003763_abnormal_thymus_physiology1.63915024
77MP0003634_abnormal_glial_cell1.61554545
78MP0002998_abnormal_bone_remodeling1.61105843
79MP0002557_abnormal_social/conspecific_i1.58428217
80MP0002882_abnormal_neuron_morphology1.56025907
81MP0000716_abnormal_immune_system1.55004877
82MP0001485_abnormal_pinna_reflex1.53043270
83MP0005386_behavior/neurological_phenoty1.52236071
84MP0004924_abnormal_behavior1.52236071
85MP0005171_absent_coat_pigmentation1.51502194
86MP0001501_abnormal_sleep_pattern1.51312644
87MP0004142_abnormal_muscle_tone1.51033917
88MP0002184_abnormal_innervation1.50090377
89MP0009840_abnormal_foam_cell1.49074912
90MP0004147_increased_porphyrin_level1.48824207
91MP0003633_abnormal_nervous_system1.45684579
92MP0000343_altered_response_to1.40810684
93MP0002396_abnormal_hematopoietic_system1.39737078
94MP0002429_abnormal_blood_cell1.37743025
95MP0003631_nervous_system_phenotype1.35985228
96MP0008874_decreased_physiological_sensi1.35180858
97MP0002722_abnormal_immune_system1.33280562
98MP0006276_abnormal_autonomic_nervous1.32750622
99MP0002066_abnormal_motor_capabilities/c1.32179079
100MP0004811_abnormal_neuron_physiology1.31914212
101MP0001984_abnormal_olfaction1.30183761
102MP0003136_yellow_coat_color1.29800658
103MP0001188_hyperpigmentation1.29360496
104MP0005310_abnormal_salivary_gland1.28438835
105MP0003453_abnormal_keratinocyte_physiol1.27457427
106MP0001502_abnormal_circadian_rhythm1.27264520
107MP0010155_abnormal_intestine_physiology1.23075264
108MP0002009_preneoplasia1.22971752
109MP0002152_abnormal_brain_morphology1.22347190
110MP0001845_abnormal_inflammatory_respons1.21934536
111MP0003632_abnormal_nervous_system1.19897406
112MP0005551_abnormal_eye_electrophysiolog1.19643894
113MP0005166_decreased_susceptibility_to1.18193647
114MP0001963_abnormal_hearing_physiology1.18081673
115MP0000703_abnormal_thymus_morphology1.17896345
116MP0000689_abnormal_spleen_morphology1.17791304
117MP0003122_maternal_imprinting1.17576836
118MP0003448_altered_tumor_morphology1.17478601
119MP0005164_abnormal_response_to1.16464743
120MP0001299_abnormal_eye_distance/1.15181814
121MP0003045_fibrosis1.14820571
122MP0004134_abnormal_chest_morphology1.14525277
123MP0005623_abnormal_meninges_morphology1.13739440
124MP0009250_abnormal_appendicular_skeleto1.12475005
125MP0003191_abnormal_cellular_cholesterol1.11577517
126MP0003172_abnormal_lysosome_physiology1.11356654
127MP0005275_abnormal_skin_tensile1.10703605
128MP0005390_skeleton_phenotype1.10282742
129MP0005076_abnormal_cell_differentiation1.09962426
130MP0002229_neurodegeneration1.09878996
131MP0002752_abnormal_somatic_nervous1.09226414
132MP0001177_atelectasis1.09065066
133MP0005058_abnormal_lysosome_morphology1.08946821
134MP0000026_abnormal_inner_ear1.06842762
135MP0004808_abnormal_hematopoietic_stem1.06045748
136MP0000858_altered_metastatic_potential1.04751980
137MP0000631_abnormal_neuroendocrine_gland1.04028790
138MP0003828_pulmonary_edema1.02615980
139MP0005503_abnormal_tendon_morphology1.01958383
140MP0003183_abnormal_peptide_metabolism1.01206676
141MP0008469_abnormal_protein_level1.00059912
142MP0003938_abnormal_ear_development0.99738244
143MP0000767_abnormal_smooth_muscle0.98849445
144MP0001851_eye_inflammation0.94710747
145MP0001664_abnormal_digestion0.91583242
146MP0001663_abnormal_digestive_system0.91328374
147MP0008004_abnormal_stomach_pH0.90925955
148MP0005394_taste/olfaction_phenotype0.87799162
149MP0005499_abnormal_olfactory_system0.87799162
150MP0000566_synostosis0.87658417
151MP0000049_abnormal_middle_ear0.87444905
152MP0005023_abnormal_wound_healing0.86169004
153MP0005167_abnormal_blood-brain_barrier0.85041133
154MP0004272_abnormal_basement_membrane0.84469388
155MP0003795_abnormal_bone_structure0.84306168
156MP0002933_joint_inflammation0.82997926
157MP0005381_digestive/alimentary_phenotyp0.82730842
158MP0001958_emphysema0.82563823
159MP0003879_abnormal_hair_cell0.79719692
160MP0009763_increased_sensitivity_to0.79385515
161MP0003861_abnormal_nervous_system0.79315485
162MP0003787_abnormal_imprinting0.78645236
163MP0002090_abnormal_vision0.75802739
164MP0000534_abnormal_ureter_morphology0.75606356
165MP0002069_abnormal_eating/drinking_beha0.74764251
166MP0002249_abnormal_larynx_morphology0.74749105
167MP0001849_ear_inflammation0.74381364
168MP0003385_abnormal_body_wall0.74230076
169MP0000249_abnormal_blood_vessel0.74229560
170MP0005195_abnormal_posterior_eye0.73633913
171MP0003566_abnormal_cell_adhesion0.71964673
172MP0001986_abnormal_taste_sensitivity0.71139454
173MP0001943_abnormal_respiration0.71099841
174MP0003942_abnormal_urinary_system0.70842175
175MP0000604_amyloidosis0.70585519
176MP0001853_heart_inflammation0.70442133
177MP0004145_abnormal_muscle_electrophysio0.70412213
178MP0000465_gastrointestinal_hemorrhage0.69631036
179MP0004883_abnormal_blood_vessel0.68870021
180MP0002233_abnormal_nose_morphology0.67125024
181MP0006292_abnormal_olfactory_placode0.66385437
182MP0003868_abnormal_feces_composition0.63853428
183MP0008789_abnormal_olfactory_epithelium0.63840028
184MP0004085_abnormal_heartbeat0.63180090
185MP0003950_abnormal_plasma_membrane0.62702800
186MP0002638_abnormal_pupillary_reflex0.61454776
187MP0005253_abnormal_eye_physiology0.60386424
188MP0003755_abnormal_palate_morphology0.59663625
189MP0003937_abnormal_limbs/digits/tail_de0.58514321
190MP0005595_abnormal_vascular_smooth0.57643030

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.23437404
2Myokymia (HP:0002411)4.82682890
3Eczematoid dermatitis (HP:0000976)4.46671952
4Abnormality of the heme biosynthetic pathway (HP:0010472)4.43914157
5Abnormality of macrophages (HP:0004311)4.40593437
6Epileptic encephalopathy (HP:0200134)4.18463252
7Aplasia involving bones of the upper limbs (HP:0009823)4.16363421
8Aplasia of the phalanges of the hand (HP:0009802)4.16363421
9Aplasia involving bones of the extremities (HP:0009825)4.16363421
10Recurrent bacterial skin infections (HP:0005406)4.01777587
11Megalencephaly (HP:0001355)4.00151315
12Degeneration of the lateral corticospinal tracts (HP:0002314)3.78410909
13Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.78410909
14Recurrent abscess formation (HP:0002722)3.67236915
15Neurofibrillary tangles (HP:0002185)3.61814576
16Focal seizures (HP:0007359)3.51651703
17Polycythemia (HP:0001901)3.47134647
18Action tremor (HP:0002345)3.46874394
19Termporal pattern (HP:0011008)3.45259597
20Insidious onset (HP:0003587)3.45259597
21Hyperventilation (HP:0002883)3.37599820
22Abnormality of the corticospinal tract (HP:0002492)3.31985474
23Progressive cerebellar ataxia (HP:0002073)3.25128573
24Cellulitis (HP:0100658)3.22591775
25Gastrointestinal infarctions (HP:0005244)3.09496504
26Gastrointestinal stroma tumor (HP:0100723)3.07312909
27Supranuclear gaze palsy (HP:0000605)3.03990528
28Chronic obstructive pulmonary disease (HP:0006510)3.01572394
29Obstructive lung disease (HP:0006536)3.01572394
30Mediastinal lymphadenopathy (HP:0100721)2.90046206
31Retinal dysplasia (HP:0007973)2.89567404
32Ankle clonus (HP:0011448)2.88143358
33Cerebral inclusion bodies (HP:0100314)2.87469279
34Febrile seizures (HP:0002373)2.87118433
35Spontaneous hematomas (HP:0007420)2.81573710
36Peripheral hypomyelination (HP:0007182)2.77966787
37Microcytic anemia (HP:0001935)2.75294229
38Broad-based gait (HP:0002136)2.75138673
39Atonic seizures (HP:0010819)2.74463185
40Cerebral aneurysm (HP:0004944)2.73646480
41Recurrent viral infections (HP:0004429)2.73483385
42Pheochromocytoma (HP:0002666)2.69990112
43Increased IgE level (HP:0003212)2.65672173
44Reticulocytosis (HP:0001923)2.64532921
45Dysdiadochokinesis (HP:0002075)2.64188041
46Emphysema (HP:0002097)2.63624442
47Meningitis (HP:0001287)2.63407906
48Poikilocytosis (HP:0004447)2.62311209
49Recurrent gram-negative bacterial infections (HP:0005420)2.61816072
50Myositis (HP:0100614)2.60732955
51Abnormal eating behavior (HP:0100738)2.60669761
52Recurrent fungal infections (HP:0002841)2.58723446
53Scanning speech (HP:0002168)2.53685093
54Orchitis (HP:0100796)2.53421858
55Dysmetria (HP:0001310)2.53381843
56Hemiparesis (HP:0001269)2.52347823
57Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.51165198
58Recurrent skin infections (HP:0001581)2.49393588
59Increased serum ferritin (HP:0003281)2.45765257
60Obstructive sleep apnea (HP:0002870)2.45500874
61Fibular aplasia (HP:0002990)2.44729796
62Truncal ataxia (HP:0002078)2.44345886
63Abnormality of liposaccharide metabolism (HP:0010968)2.42701577
64Abnormality of glycosphingolipid metabolism (HP:0004343)2.42701577
65Abnormality of glycolipid metabolism (HP:0010969)2.42701577
66Spastic gait (HP:0002064)2.40576092
67Diplopia (HP:0000651)2.38541384
68Abnormality of binocular vision (HP:0011514)2.38541384
69Vasculitis (HP:0002633)2.37641271
70Generalized tonic-clonic seizures (HP:0002069)2.37103186
71Retrobulbar optic neuritis (HP:0100654)2.36766808
72Optic neuritis (HP:0100653)2.36766808
73Slender build (HP:0001533)2.36247036
74Hypertensive crisis (HP:0100735)2.35574228
75Hypochromic microcytic anemia (HP:0004840)2.34465318
76Clumsiness (HP:0002312)2.31770045
77Prolonged bleeding time (HP:0003010)2.30318221
78Abnormal hemoglobin (HP:0011902)2.29914289
79Segmental peripheral demyelination/remyelination (HP:0003481)2.29403700
80Agammaglobulinemia (HP:0004432)2.27205033
81Abnormality of the middle phalanges of the toes (HP:0010183)2.25886285
82Neuroendocrine neoplasm (HP:0100634)2.24746502
83Anxiety (HP:0000739)2.24705246
84Genu recurvatum (HP:0002816)2.23088786
85Dialeptic seizures (HP:0011146)2.21928448
86Slow saccadic eye movements (HP:0000514)2.21585176
87Absence seizures (HP:0002121)2.21158774
88Lower limb muscle weakness (HP:0007340)2.20633599
89Gingivitis (HP:0000230)2.20061154
90Osteomyelitis (HP:0002754)2.16905795
91Urticaria (HP:0001025)2.16773694
92Lymphopenia (HP:0001888)2.15727302
93Narrow nasal bridge (HP:0000446)2.15698653
94Intention tremor (HP:0002080)2.15506410
95Gaze-evoked nystagmus (HP:0000640)2.13620705
96Hypochromic anemia (HP:0001931)2.13001405
97Colitis (HP:0002583)2.11071811
98Visual hallucinations (HP:0002367)2.11065905
99Dilatation of the ascending aorta (HP:0005111)2.10797969
100Urinary bladder sphincter dysfunction (HP:0002839)2.10739897
101Viral hepatitis (HP:0006562)2.10095141
102Increased variability in muscle fiber diameter (HP:0003557)2.09388476
103Polyphagia (HP:0002591)2.09319678
104Chronic otitis media (HP:0000389)2.08570747
105Premature rupture of membranes (HP:0001788)2.07259091
106Abnormal delayed hypersensitivity skin test (HP:0002963)2.05809760
107Epileptiform EEG discharges (HP:0011182)2.05247769
108Abnormality of iron homeostasis (HP:0011031)2.04997700
109Excessive salivation (HP:0003781)2.04988471
110Drooling (HP:0002307)2.04988471
111Coronal craniosynostosis (HP:0004440)2.04706559
112Humeroradial synostosis (HP:0003041)2.04603530
113Synostosis involving the elbow (HP:0003938)2.04603530
114Abnormality of cells of the lymphoid lineage (HP:0012140)2.03527936
115Broad metatarsal (HP:0001783)2.03153283
116Impaired vibration sensation in the lower limbs (HP:0002166)2.02937452
117Thickened helices (HP:0000391)2.02606613
118Abnormality of the nasal mucosa (HP:0000433)2.00049644
119EEG with generalized epileptiform discharges (HP:0011198)1.98546664
120Chronic mucocutaneous candidiasis (HP:0002728)1.98297602
121Recurrent cutaneous fungal infections (HP:0011370)1.98297602
122Urinary urgency (HP:0000012)1.98159585
123Hypoplastic left heart (HP:0004383)1.97427560
124Autoimmune thrombocytopenia (HP:0001973)1.97226291
125Restrictive lung disease (HP:0002091)1.97072970
126Encephalitis (HP:0002383)1.96657130
127Myelomeningocele (HP:0002475)1.96535557
128Peritonitis (HP:0002586)1.95194129
129Pulmonary infiltrates (HP:0002113)1.95090296
130Polygenic inheritance (HP:0010982)1.94133028
131Stomatitis (HP:0010280)1.93767327
132Depression (HP:0000716)1.92977427
133Poor eye contact (HP:0000817)1.92925897
134Hypsarrhythmia (HP:0002521)1.92756528
135Subacute progressive viral hepatitis (HP:0006572)1.92607199
136Abnormality of reticulocytes (HP:0004312)1.90460868
137Onion bulb formation (HP:0003383)1.90446616
138Keratoconjunctivitis sicca (HP:0001097)1.89568830
139Insomnia (HP:0100785)1.88321623
140Recurrent lower respiratory tract infections (HP:0002783)1.87397530
141Epistaxis (HP:0000421)1.87192818
142Morphological abnormality of the inner ear (HP:0011390)1.86971841
143Hypercortisolism (HP:0001578)1.86032889
144Alacrima (HP:0000522)1.85975845
145Absent speech (HP:0001344)1.83974750
146Blue irides (HP:0000635)1.83934079
147Diaphragmatic weakness (HP:0009113)1.83907796
148Abnormality of the phalanges of the 2nd finger (HP:0009541)1.83512871
149Cutaneous finger syndactyly (HP:0010554)1.81806117
150Gait imbalance (HP:0002141)1.81515651
151Relative macrocephaly (HP:0004482)1.81444264
152Akinesia (HP:0002304)1.81335334
153Papilloma (HP:0012740)1.81238418
154Verrucae (HP:0200043)1.81238418
155Genetic anticipation (HP:0003743)1.80558559
156Increased circulating renin level (HP:0000848)1.80542994
157Stereotypic behavior (HP:0000733)1.79553944
158Abnormality of the fingertips (HP:0001211)1.79234378
159Limb dystonia (HP:0002451)1.78667970
160Generalized myoclonic seizures (HP:0002123)1.78389168
161Parakeratosis (HP:0001036)1.77562646
162Buphthalmos (HP:0000557)1.76985451
163Abnormal platelet function (HP:0011869)1.76737365
164Impaired platelet aggregation (HP:0003540)1.76737365
165Postural instability (HP:0002172)1.75605308
166Split foot (HP:0001839)1.74759153
167Arthralgia (HP:0002829)1.74283896
168Gastrointestinal inflammation (HP:0004386)1.74018195
169Petechiae (HP:0000967)1.73193468
170Nasal polyposis (HP:0100582)1.73173493
171Generalized hypotonia (HP:0001290)1.72851312
172Hemiplegia (HP:0002301)1.72306697
173Impaired social interactions (HP:0000735)1.71750028
174Abnormal social behavior (HP:0012433)1.71750028
175Hemoptysis (HP:0002105)1.71357490
176Fetal akinesia sequence (HP:0001989)1.70887095
177Migraine (HP:0002076)1.70680399
178Overgrowth (HP:0001548)1.70605200
179Vaginal atresia (HP:0000148)1.69694858
180Paralysis (HP:0003470)1.68320052
181Turricephaly (HP:0000262)1.67904123
182Abnormality of skeletal muscle fiber size (HP:0012084)1.67832354
183Disproportionate tall stature (HP:0001519)1.67764409
184Purpura (HP:0000979)1.67597298
185Genital tract atresia (HP:0001827)1.67184005
186Meningocele (HP:0002435)1.67120263
187Specific learning disability (HP:0001328)1.65331248
188Mixed hearing impairment (HP:0000410)1.64283920
189Amblyopia (HP:0000646)1.64190122
190Short tibia (HP:0005736)1.63656906
191Ulnar claw (HP:0001178)1.62964982
192Morphological abnormality of the middle ear (HP:0008609)1.62460209
193Cutaneous syndactyly (HP:0012725)1.61931140

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.72983290
2RIPK44.20599593
3EPHA43.59801541
4NTRK33.21910405
5MARK13.05860646
6PRPF4B3.05054497
7MAP4K12.98214458
8MAP3K132.77668626
9NTRK22.54894070
10ERN12.52649377
11STK392.52590931
12TNIK2.27779794
13TRIB32.13992046
14MAP2K72.08147402
15MINK12.04778016
16MAP3K101.98293408
17MAP3K41.92162226
18TAOK21.87127554
19SGK4941.80749011
20SGK2231.80749011
21OXSR11.79400769
22IRAK31.79148524
23TYK21.74611007
24MAP2K31.72641360
25IRAK41.70819785
26MAPK131.70627257
27SMG11.70123443
28PHKG11.66517298
29PHKG21.66517298
30PLK21.66017603
31BLK1.63231114
32CSK1.61877355
33MAP3K141.59650801
34PAK61.58455368
35NTRK11.50695824
36EPHB11.49665799
37CDK51.41198218
38PDGFRA1.38995310
39MAPKAPK51.38633327
40PKN11.35529805
41MAP3K111.34219111
42UHMK11.32733868
43SGK21.32626775
44PRKD31.30001383
45CDK191.29928313
46MAP3K91.28790120
47IKBKE1.28049694
48ZAP701.26861790
49ARAF1.23543240
50JAK31.22511441
51RIPK11.22109728
52TAOK11.19387571
53BCR1.18544567
54MATK1.16399867
55TYRO31.14976505
56SYK1.14599298
57MAP3K31.14245391
58MAP3K11.11978076
59CDC42BPA1.11753033
60MUSK1.11116701
61TBK11.09333293
62DYRK1A1.08780875
63CAMK2A1.08740212
64NME21.07830779
65FGFR21.06317630
66NEK61.06086479
67WNK41.05572764
68KIT1.04164469
69DAPK21.04014218
70ROCK21.03788881
71PNCK1.03559910
72MOS1.01425121
73PRKCG1.01173288
74CLK10.98870645
75SIK10.98687908
76BTK0.98682343
77GRK60.96430764
78JAK10.95719951
79KSR10.94897270
80WNK10.93766665
81SGK30.92426643
82CAMKK10.92086093
83CDK140.91777289
84LYN0.91598893
85SIK20.89915940
86DYRK20.89907748
87FES0.88607739
88CDK180.86858118
89LMTK20.86573502
90PAK30.86415757
91CAMK2B0.85032345
92BMX0.84564615
93CDK150.83861238
94MAP2K40.83097707
95MKNK20.82226907
96RAF10.81958498
97PRKCE0.81321520
98MARK20.80343684
99RPS6KL10.79639178
100RPS6KC10.79639178
101JAK20.78481367
102TLK10.78314067
103HCK0.78196175
104PIM10.76687374
105PRKD20.76665634
106DDR20.75839199
107FGR0.73003484
108CDK11A0.72881571
109PRKCH0.72846670
110MAPK70.71876924
111CSNK1G20.71825360
112MAP3K80.70897501
113SGK10.70601912
114GRK50.69765297
115MKNK10.69453956
116CDK120.68434985
117TXK0.67431927
118IKBKB0.67003499
119RPS6KA20.65767023
120BMPR20.65194059
121PINK10.65164291
122BRAF0.63964754
123EEF2K0.63723379
124RPS6KA60.63456623
125TAOK30.63382498
126NME10.63290977
127PTK60.63137615
128KSR20.62758113
129PDGFRB0.62428489
130MAP3K120.61537495
131CAMK10.60918282
132HIPK20.60663133
133BMPR1B0.59829675
134MAPK120.59760452
135LATS20.58645936
136MAPK40.58145254
137ROCK10.56312379
138TNK20.55937927
139CAMK1G0.55910278
140FER0.55852426
141CAMK2D0.55564654
142PTK2B0.54878925
143PIK3CA0.53850610
144ADRBK10.53112326
145IRAK20.53072485
146PDK10.51161116
147LCK0.50171053
148STK110.50121836
149PRKCQ0.48156344
150MARK30.47861987
151PDPK10.47760088
152FGFR40.47485555
153DYRK30.47346576
154CHUK0.46712341
155AKT30.46701359
156CSNK1A1L0.46662830
157PRKG10.46537546
158SIK30.46220088
159CDK30.45475979
160CSF1R0.44708366
161CAMK2G0.44062882
162FYN0.42562373
163CSNK1G30.42322215
164EPHA30.42073760
165RPS6KA30.41479774
166RET0.41445252
167TGFBR20.41414819
168DMPK0.40898766
169ERBB30.40631296
170CSNK1A10.40628453
171MAPK100.40390574

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.96468501
2Nitrogen metabolism_Homo sapiens_hsa009102.80379827
3Steroid biosynthesis_Homo sapiens_hsa001002.57112722
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.45671780
5Glutamatergic synapse_Homo sapiens_hsa047242.44874740
6GABAergic synapse_Homo sapiens_hsa047272.40481712
7B cell receptor signaling pathway_Homo sapiens_hsa046622.36094843
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.26046515
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.24637682
10Osteoclast differentiation_Homo sapiens_hsa043802.21488007
11Synaptic vesicle cycle_Homo sapiens_hsa047212.19918352
12Leishmaniasis_Homo sapiens_hsa051402.15103423
13Malaria_Homo sapiens_hsa051442.13059681
14Circadian entrainment_Homo sapiens_hsa047132.11953684
15Morphine addiction_Homo sapiens_hsa050322.09935623
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98849918
17Olfactory transduction_Homo sapiens_hsa047401.88330238
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.85680407
19Long-term potentiation_Homo sapiens_hsa047201.78457687
20Salivary secretion_Homo sapiens_hsa049701.77783886
21Dopaminergic synapse_Homo sapiens_hsa047281.73157260
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.70402322
23Long-term depression_Homo sapiens_hsa047301.67621613
24Gastric acid secretion_Homo sapiens_hsa049711.67220784
25Pancreatic secretion_Homo sapiens_hsa049721.67011275
26Cholinergic synapse_Homo sapiens_hsa047251.65873328
27Serotonergic synapse_Homo sapiens_hsa047261.65335564
28Axon guidance_Homo sapiens_hsa043601.63471588
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.61246086
30Amphetamine addiction_Homo sapiens_hsa050311.60322017
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.56557621
32Toxoplasmosis_Homo sapiens_hsa051451.54287756
33Tuberculosis_Homo sapiens_hsa051521.51461501
34Graft-versus-host disease_Homo sapiens_hsa053321.51346349
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.50525775
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.50224621
37Acute myeloid leukemia_Homo sapiens_hsa052211.50054547
38Fatty acid elongation_Homo sapiens_hsa000621.49765180
39Insulin secretion_Homo sapiens_hsa049111.46825942
40Allograft rejection_Homo sapiens_hsa053301.45900465
41Cocaine addiction_Homo sapiens_hsa050301.45011757
42African trypanosomiasis_Homo sapiens_hsa051431.44756251
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.42116245
44TNF signaling pathway_Homo sapiens_hsa046681.41353266
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.37733220
46Taste transduction_Homo sapiens_hsa047421.37061907
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.35922471
48Renin secretion_Homo sapiens_hsa049241.32919253
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.32666295
50Chronic myeloid leukemia_Homo sapiens_hsa052201.31364772
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.30891650
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29910169
53Autoimmune thyroid disease_Homo sapiens_hsa053201.29024350
54Ether lipid metabolism_Homo sapiens_hsa005651.28915569
55T cell receptor signaling pathway_Homo sapiens_hsa046601.28301374
56Chemokine signaling pathway_Homo sapiens_hsa040621.28093041
57Staphylococcus aureus infection_Homo sapiens_hsa051501.27174913
58Calcium signaling pathway_Homo sapiens_hsa040201.26363229
59VEGF signaling pathway_Homo sapiens_hsa043701.26271091
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.25900549
61Intestinal immune network for IgA production_Homo sapiens_hsa046721.24939371
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.22479770
63Gap junction_Homo sapiens_hsa045401.21664674
64Prion diseases_Homo sapiens_hsa050201.21658913
65Hepatitis B_Homo sapiens_hsa051611.21141066
66Influenza A_Homo sapiens_hsa051641.20717842
67Hematopoietic cell lineage_Homo sapiens_hsa046401.20669644
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.20041267
69NOD-like receptor signaling pathway_Homo sapiens_hsa046211.19043358
70Rheumatoid arthritis_Homo sapiens_hsa053231.18817346
71Aldosterone synthesis and secretion_Homo sapiens_hsa049251.17965365
72Non-small cell lung cancer_Homo sapiens_hsa052231.15553158
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15208427
74Bladder cancer_Homo sapiens_hsa052191.14950357
75Notch signaling pathway_Homo sapiens_hsa043301.14618377
76Fatty acid biosynthesis_Homo sapiens_hsa000611.13921933
77Primary immunodeficiency_Homo sapiens_hsa053401.12553288
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12340141
79Oxytocin signaling pathway_Homo sapiens_hsa049211.11341209
80Asthma_Homo sapiens_hsa053101.09535891
81Measles_Homo sapiens_hsa051621.08022458
82Apoptosis_Homo sapiens_hsa042101.04782277
83Melanogenesis_Homo sapiens_hsa049161.03313876
84Jak-STAT signaling pathway_Homo sapiens_hsa046301.01847416
85Pancreatic cancer_Homo sapiens_hsa052121.01315369
86cAMP signaling pathway_Homo sapiens_hsa040241.01024055
87Viral myocarditis_Homo sapiens_hsa054161.00822046
88Collecting duct acid secretion_Homo sapiens_hsa049661.00313229
89Hepatitis C_Homo sapiens_hsa051600.99835735
90Amoebiasis_Homo sapiens_hsa051460.98132671
91ErbB signaling pathway_Homo sapiens_hsa040120.97418109
92Prolactin signaling pathway_Homo sapiens_hsa049170.96460400
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.95715515
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95598815
95Glioma_Homo sapiens_hsa052140.94910959
96GnRH signaling pathway_Homo sapiens_hsa049120.94568390
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93005630
98Phagosome_Homo sapiens_hsa041450.91889447
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91558552
100Dorso-ventral axis formation_Homo sapiens_hsa043200.91365735
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.89368759
102Phototransduction_Homo sapiens_hsa047440.89346377
103Type I diabetes mellitus_Homo sapiens_hsa049400.89025433
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88751819
105Antigen processing and presentation_Homo sapiens_hsa046120.88395136
106Small cell lung cancer_Homo sapiens_hsa052220.87928602
107Ras signaling pathway_Homo sapiens_hsa040140.86828353
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.85513028
109Legionellosis_Homo sapiens_hsa051340.84892803
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84513818
111Pertussis_Homo sapiens_hsa051330.84471953
112Herpes simplex infection_Homo sapiens_hsa051680.83294357
113Leukocyte transendothelial migration_Homo sapiens_hsa046700.82168919
114Platelet activation_Homo sapiens_hsa046110.82122776
115HIF-1 signaling pathway_Homo sapiens_hsa040660.81331224
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80359857
117Salmonella infection_Homo sapiens_hsa051320.79592451
118Focal adhesion_Homo sapiens_hsa045100.79543204
119HTLV-I infection_Homo sapiens_hsa051660.79122472
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.79040802
121Vibrio cholerae infection_Homo sapiens_hsa051100.77604344
122Prostate cancer_Homo sapiens_hsa052150.75881929
123ECM-receptor interaction_Homo sapiens_hsa045120.75656342
124Type II diabetes mellitus_Homo sapiens_hsa049300.75002694
125Estrogen signaling pathway_Homo sapiens_hsa049150.73829370
126Other glycan degradation_Homo sapiens_hsa005110.73804157
127Renal cell carcinoma_Homo sapiens_hsa052110.73601916
128cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72771237
129Shigellosis_Homo sapiens_hsa051310.72522557
130Rap1 signaling pathway_Homo sapiens_hsa040150.71431061
131Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69653777
132Choline metabolism in cancer_Homo sapiens_hsa052310.67798914
133Butanoate metabolism_Homo sapiens_hsa006500.66574521
134Wnt signaling pathway_Homo sapiens_hsa043100.66354037
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65529073
136Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64357211
137Epstein-Barr virus infection_Homo sapiens_hsa051690.63155790
138MAPK signaling pathway_Homo sapiens_hsa040100.61823432
139Dilated cardiomyopathy_Homo sapiens_hsa054140.60966302
140Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60058140
141Viral carcinogenesis_Homo sapiens_hsa052030.59966585
142Colorectal cancer_Homo sapiens_hsa052100.59471431
143Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57783693
144Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56907428
145Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56700185
146Cardiac muscle contraction_Homo sapiens_hsa042600.55604813
147Proteoglycans in cancer_Homo sapiens_hsa052050.55446965
148Tight junction_Homo sapiens_hsa045300.54779981
149Pathways in cancer_Homo sapiens_hsa052000.54234025
150mTOR signaling pathway_Homo sapiens_hsa041500.54056575
151Thyroid cancer_Homo sapiens_hsa052160.53856670
152Lysosome_Homo sapiens_hsa041420.53812525
153Protein digestion and absorption_Homo sapiens_hsa049740.53628505
154Melanoma_Homo sapiens_hsa052180.53514878
155Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52701459
156Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52598712
157Hedgehog signaling pathway_Homo sapiens_hsa043400.51737356
158Ovarian steroidogenesis_Homo sapiens_hsa049130.51660078
159Alzheimers disease_Homo sapiens_hsa050100.51237910
160Sphingolipid metabolism_Homo sapiens_hsa006000.49332256
161Thyroid hormone synthesis_Homo sapiens_hsa049180.47379482
162Hippo signaling pathway_Homo sapiens_hsa043900.43028546
163Endocytosis_Homo sapiens_hsa041440.42785034
164Circadian rhythm_Homo sapiens_hsa047100.41509682
165Endometrial cancer_Homo sapiens_hsa052130.40721810
166Oxidative phosphorylation_Homo sapiens_hsa001900.40330506
167Fatty acid metabolism_Homo sapiens_hsa012120.39550089
168Basal cell carcinoma_Homo sapiens_hsa052170.38645112
169Vitamin B6 metabolism_Homo sapiens_hsa007500.38333878
170Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36282589
171Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36243186
172Alcoholism_Homo sapiens_hsa050340.35799705
173Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34642757
174Neurotrophin signaling pathway_Homo sapiens_hsa047220.34487353
175Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33682062

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