CHST3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme which catalyzes the sulfation of chondroitin, a proteoglycan found in the extracellular matrix and most cells which is involved in cell migration and differentiation. Mutations in this gene are associated with spondylepiphyseal dysplasia and humerospinal dysostosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1B cell receptor signaling pathway (GO:0050853)9.02490502
2positive regulation of gamma-delta T cell activation (GO:0046645)6.72840513
3positive regulation of B cell differentiation (GO:0045579)5.94850332
4hemidesmosome assembly (GO:0031581)5.86943782
5regulation of B cell differentiation (GO:0045577)5.46585882
6regulation of B cell receptor signaling pathway (GO:0050855)5.06054561
7serine transport (GO:0032329)5.04670189
8B cell proliferation (GO:0042100)4.94975310
9regulation of histone H3-K9 methylation (GO:0051570)4.84637781
10regulation of gamma-delta T cell differentiation (GO:0045586)4.83464177
11L-serine transport (GO:0015825)4.80485095
12regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.66534061
13regulation of gamma-delta T cell activation (GO:0046643)4.52824338
14cellular response to zinc ion (GO:0071294)4.49133923
15negative regulation of histone methylation (GO:0031061)4.47823980
16tachykinin receptor signaling pathway (GO:0007217)4.41744643
17regulation of platelet aggregation (GO:0090330)4.29637956
18negative regulation of B cell proliferation (GO:0030889)4.29287102
19V(D)J recombination (GO:0033151)4.26602139
20positive thymic T cell selection (GO:0045059)4.13392233
21mature B cell differentiation (GO:0002335)4.12005289
22B cell homeostasis (GO:0001782)4.11928020
23cell adhesion mediated by integrin (GO:0033627)4.10395406
24antigen processing and presentation of endogenous antigen (GO:0019883)4.10108637
25endodermal cell differentiation (GO:0035987)4.08803282
26regulation of superoxide anion generation (GO:0032928)4.03467209
27antigen receptor-mediated signaling pathway (GO:0050851)4.00051986
28regulation of B cell proliferation (GO:0030888)3.96540430
29negative regulation of phagocytosis (GO:0050765)3.91143524
30neutrophil activation (GO:0042119)3.89988422
31skin morphogenesis (GO:0043589)3.86950309
32doxorubicin metabolic process (GO:0044598)3.83582616
33daunorubicin metabolic process (GO:0044597)3.83582616
34polyketide metabolic process (GO:0030638)3.83582616
35cell-substrate junction assembly (GO:0007044)3.81814893
36regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.79461977
37collagen fibril organization (GO:0030199)3.78404758
38positive regulation by host of viral transcription (GO:0043923)3.71980779
39neutrophil activation involved in immune response (GO:0002283)3.60451694
40negative regulation of bone resorption (GO:0045779)3.59459344
41vesicle targeting (GO:0006903)3.57881225
42B cell activation (GO:0042113)3.57456166
43positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.56880908
44planar cell polarity pathway involved in neural tube closure (GO:0090179)3.51856514
45chondrocyte proliferation (GO:0035988)3.50854290
46protein heterotrimerization (GO:0070208)3.50031674
47histone H3-K36 demethylation (GO:0070544)3.49535181
48B cell differentiation (GO:0030183)3.47872203
49regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.42353001
50positive regulation of Rap GTPase activity (GO:0032854)3.42001393
51lymph vessel development (GO:0001945)3.37616370
52regulation of alpha-beta T cell proliferation (GO:0046640)3.37315337
53granulocyte activation (GO:0036230)3.37166495
54negative regulation of chondrocyte differentiation (GO:0032331)3.37047736
55positive regulation of gene expression, epigenetic (GO:0045815)3.34012864
56dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.33300613
57immune response-activating cell surface receptor signaling pathway (GO:0002429)3.32196834
58regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.29902974
59positive regulation of mast cell degranulation (GO:0043306)3.27086990
60positive regulation of mast cell activation involved in immune response (GO:0033008)3.27086990
61regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.26721119
62regulation of transforming growth factor beta2 production (GO:0032909)3.26038735
63lymph node development (GO:0048535)3.25114109
64natural killer cell differentiation (GO:0001779)3.21604633
65cell migration involved in sprouting angiogenesis (GO:0002042)3.20009222
66desmosome organization (GO:0002934)3.19684519
67neuron projection extension involved in neuron projection guidance (GO:1902284)3.17837527
68axon extension involved in axon guidance (GO:0048846)3.17837527
69retina vasculature morphogenesis in camera-type eye (GO:0061299)3.16458126
70positive regulation of B cell proliferation (GO:0030890)3.15750769
71basement membrane organization (GO:0071711)3.15517418
72positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.15484621
73leukocyte aggregation (GO:0070486)3.11901216
74positive regulation of B cell activation (GO:0050871)3.09201162
75T cell selection (GO:0045058)3.08884521
76histone H3-K4 trimethylation (GO:0080182)3.08515931
77macrophage activation involved in immune response (GO:0002281)3.06310210
78adaptation of signaling pathway (GO:0023058)3.05067673
79defense response to protozoan (GO:0042832)3.03296444
80regulation of histone methylation (GO:0031060)3.02208887
81positive regulation of granulocyte differentiation (GO:0030854)2.99324525
82germinal center formation (GO:0002467)2.99247132
83mononuclear cell proliferation (GO:0032943)2.98695510
84negative regulation of catenin import into nucleus (GO:0035414)2.98329118
85regulation of Rap GTPase activity (GO:0032317)2.97413226
86positive regulation of histone deacetylation (GO:0031065)2.97124435
87* lymphocyte homeostasis (GO:0002260)2.96855300
88lymphocyte proliferation (GO:0046651)2.95144992
89positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.94684329
90regulation of B cell apoptotic process (GO:0002902)2.94249978
91regulation of B cell activation (GO:0050864)2.93837026
92regulation of interferon-beta biosynthetic process (GO:0045357)2.93288551
93endothelial cell morphogenesis (GO:0001886)2.92960401
94positive regulation of astrocyte differentiation (GO:0048711)2.92861468
95tolerance induction (GO:0002507)2.91746154
96paraxial mesoderm development (GO:0048339)2.90928970
97regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.90083404
98epithelial cell-cell adhesion (GO:0090136)2.89236315
99kidney mesenchyme development (GO:0072074)2.89173733
100substrate-dependent cell migration (GO:0006929)2.87240422
101negative regulation of bone remodeling (GO:0046851)2.86598013
102Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.86427333
103positive T cell selection (GO:0043368)2.85755759
104cellular extravasation (GO:0045123)2.85469355
105collagen metabolic process (GO:0032963)2.85176359
106histone H3-K9 modification (GO:0061647)2.83816566
107adherens junction assembly (GO:0034333)2.83426015
108cytoskeletal anchoring at plasma membrane (GO:0007016)2.83252734
109mucosal-associated lymphoid tissue development (GO:0048537)2.81192084
110Peyers patch development (GO:0048541)2.81192084
111respiratory burst (GO:0045730)2.80960503
112regulation of interleukin-12 biosynthetic process (GO:0045075)2.78203897
113hippo signaling (GO:0035329)2.77696555
114regulation of axon extension involved in axon guidance (GO:0048841)2.77583151
115atrioventricular valve morphogenesis (GO:0003181)2.77243480
116type B pancreatic cell proliferation (GO:0044342)2.77000559
117vascular endothelial growth factor signaling pathway (GO:0038084)2.76906671
118maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.76081083
119regulation of establishment of planar polarity (GO:0090175)2.75909056
120notochord development (GO:0030903)2.75833142
121protein retention in ER lumen (GO:0006621)2.75652749
122regulation of homotypic cell-cell adhesion (GO:0034110)2.75581856
123extracellular matrix assembly (GO:0085029)2.74795220
124positive regulation of cell adhesion mediated by integrin (GO:0033630)2.74695326
125Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)2.74538241
126immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00022.74538241
127Fc-gamma receptor signaling pathway (GO:0038094)2.74538241
128blood vessel endothelial cell migration (GO:0043534)2.74475811
129cellular response to interleukin-15 (GO:0071350)2.73975546
130mature B cell differentiation involved in immune response (GO:0002313)2.72228442
131positive regulation of osteoblast proliferation (GO:0033690)2.71742627
132positive regulation of interleukin-2 production (GO:0032743)2.70941596
133Fc receptor mediated stimulatory signaling pathway (GO:0002431)2.70212564
134negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.70125246
135collagen catabolic process (GO:0030574)2.68699997
136regulation of mast cell degranulation (GO:0043304)2.68199668
137regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.67320186
138T cell migration (GO:0072678)2.67262579
139heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.66688421
140negative regulation of calcium ion transport into cytosol (GO:0010523)2.66607418
141antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.66207691
142antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.66207691
143positive regulation of alpha-beta T cell proliferation (GO:0046641)2.66065355
144hepatocyte apoptotic process (GO:0097284)2.66017754
145regulation of extracellular matrix disassembly (GO:0010715)2.65947597
146histamine secretion (GO:0001821)2.65592345
147multicellular organismal macromolecule metabolic process (GO:0044259)2.65533436
148peptidyl-proline hydroxylation (GO:0019511)2.64679442
149* leukocyte homeostasis (GO:0001776)2.64558455
150lymphangiogenesis (GO:0001946)2.64160171
151cellular response to vitamin (GO:0071295)2.63824770
152extracellular matrix disassembly (GO:0022617)2.63545652
153negative regulation of axon extension involved in axon guidance (GO:0048843)2.61768604
154dermatan sulfate biosynthetic process (GO:0030208)2.61666380
155semaphorin-plexin signaling pathway (GO:0071526)2.61650886
156axon extension (GO:0048675)2.59533099
157COPI coating of Golgi vesicle (GO:0048205)2.59475919
158Golgi transport vesicle coating (GO:0048200)2.59475919
159glomerular basement membrane development (GO:0032836)2.58508936
160positive regulation of blood vessel endothelial cell migration (GO:0043536)2.58236042
161cell-substrate adherens junction assembly (GO:0007045)2.57871212
162focal adhesion assembly (GO:0048041)2.57871212
163regulation of cardioblast differentiation (GO:0051890)2.56794813
164metanephric mesenchyme development (GO:0072075)2.55842654
165protein hydroxylation (GO:0018126)2.55256342
166heparan sulfate proteoglycan metabolic process (GO:0030201)2.54864069
167wound healing, spreading of epidermal cells (GO:0035313)2.52466649
168cellular response to vitamin D (GO:0071305)2.51649305
169negative regulation of keratinocyte proliferation (GO:0010839)2.51640980
170extracellular matrix organization (GO:0030198)2.51293463
171multicellular organismal metabolic process (GO:0044236)2.50509989
172extracellular structure organization (GO:0043062)2.50213571
173negative regulation of protein localization to cell surface (GO:2000009)2.49834194
174Notch signaling involved in heart development (GO:0061314)2.49180741
175negative regulation of cartilage development (GO:0061037)2.49166695
176mesodermal cell differentiation (GO:0048333)2.48507210
177convergent extension (GO:0060026)2.46116355
178protein localization to endosome (GO:0036010)2.45507939
179cochlea morphogenesis (GO:0090103)2.45476186
180morphogenesis of an epithelial sheet (GO:0002011)2.45376214
181mesenchymal-epithelial cell signaling (GO:0060638)2.44483608
182dermatan sulfate metabolic process (GO:0030205)2.44039569
183negative regulation of fatty acid transport (GO:2000192)2.43713784
184wound healing, spreading of cells (GO:0044319)2.43186939
185cell migration involved in heart development (GO:0060973)2.42756469
186regulation of axon guidance (GO:1902667)2.42735085
187positive regulation of cartilage development (GO:0061036)2.42083694
188substrate adhesion-dependent cell spreading (GO:0034446)2.41623600
189vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.41381058
190endothelial cell chemotaxis (GO:0035767)2.39543184
191multicellular organismal catabolic process (GO:0044243)2.39497491
192extracellular fibril organization (GO:0043206)2.38958925
193barbed-end actin filament capping (GO:0051016)2.36848333
194positive regulation of axon extension (GO:0045773)2.35157496
195stress fiber assembly (GO:0043149)2.35112602
196G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.34910572
197muscle cell migration (GO:0014812)2.33582560
198heart valve morphogenesis (GO:0003179)2.32995067
199non-canonical Wnt signaling pathway (GO:0035567)2.32428780
200lens fiber cell development (GO:0070307)2.31320218

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.36647706
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.29636430
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.15507013
4TRIM28_21343339_ChIP-Seq_HEK293_Human4.85393875
5MYC_22102868_ChIP-Seq_BL_Human4.84410334
6E2F7_22180533_ChIP-Seq_HELA_Human4.42305079
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.17312749
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.85893565
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.84960280
10VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human3.54490005
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.45838250
12FOXM1_23109430_ChIP-Seq_U2OS_Human3.40878001
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.36825735
14* VDR_21846776_ChIP-Seq_THP-1_Human3.33901077
15RARG_19884340_ChIP-ChIP_MEFs_Mouse3.29425019
16RUNX_20019798_ChIP-Seq_JUKART_Human3.26735394
17IRF8_21731497_ChIP-ChIP_J774_Mouse3.24212291
18E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human3.02645121
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.97965191
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.91060718
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.88727953
22EZH2_22144423_ChIP-Seq_EOC_Human2.88131902
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.80813670
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.77077607
25CLOCK_20551151_ChIP-Seq_293T_Human2.50163912
26SCL_19346495_ChIP-Seq_HPC-7_Human2.42665503
27MYB_26560356_Chip-Seq_TH1_Human2.35507710
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.33659981
29EP300_21415370_ChIP-Seq_HL-1_Mouse2.28931761
30MYB_26560356_Chip-Seq_TH2_Human2.26316262
31TP63_19390658_ChIP-ChIP_HaCaT_Human2.25761442
32NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human2.21772621
33SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.20293935
34RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.19964286
35UTX_26944678_Chip-Seq_JUKART_Human2.17495252
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.13823759
37EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.09960156
38MAF_26560356_Chip-Seq_TH1_Human2.04664078
39ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.02350145
40* CJUN_26792858_Chip-Seq_BT549_Human2.01574586
41* VDR_24763502_ChIP-Seq_THP-1_Human1.96433709
42* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.95863552
43KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.93259681
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.87644070
45WT1_19549856_ChIP-ChIP_CCG9911_Human1.86942400
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.86650058
47BRD4_25478319_ChIP-Seq_HGPS_Human1.85793419
48SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.81138933
49SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.81138933
50TCF7_22412390_ChIP-Seq_EML_Mouse1.79540872
51TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.79130651
52SOX9_24532713_ChIP-Seq_HFSC_Mouse1.78411690
53HIF1A_21447827_ChIP-Seq_MCF-7_Human1.76159695
54CIITA_25753668_ChIP-Seq_RAJI_Human1.74059758
55RNF2_18974828_ChIP-Seq_MESCs_Mouse1.72127117
56EZH2_18974828_ChIP-Seq_MESCs_Mouse1.72127117
57EED_16625203_ChIP-ChIP_MESCs_Mouse1.71513881
58P300_27058665_Chip-Seq_ZR-75-30cells_Human1.70874906
59NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.69794235
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.69725048
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.65179001
62KDM2B_26808549_Chip-Seq_DND41_Human1.63510704
63TP53_18474530_ChIP-ChIP_U2OS_Human1.62841547
64SPI1_23127762_ChIP-Seq_K562_Human1.61818981
65SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.60125220
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.58075534
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.58034779
68CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.56888881
69SPI1_23547873_ChIP-Seq_NB4_Human1.56494588
70SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.56241939
71* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.51898325
72* UBF1/2_26484160_Chip-Seq_HMECs_Human1.49770079
73* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.48792605
74ZNF263_19887448_ChIP-Seq_K562_Human1.48618685
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.48353505
76PPAR_26484153_Chip-Seq_NCI-H1993_Human1.46338313
77CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.46044143
78TP53_16413492_ChIP-PET_HCT116_Human1.45099683
79* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44957189
80SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43992864
81TP53_22127205_ChIP-Seq_IMR90_Human1.43275283
82NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.40960369
83* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.40867359
84SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.40041249
85TBX20_22080862_ChIP-Seq_HEART_Mouse1.39183863
86TBX20_22328084_ChIP-Seq_HEART_Mouse1.39183863
87E2F4_17652178_ChIP-ChIP_JURKAT_Human1.37451363
88ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36521771
89ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.31639270
90EGR1_19374776_ChIP-ChIP_THP-1_Human1.31548326
91EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31357711
92ESR1_21235772_ChIP-Seq_MCF-7_Human1.30963266
93TP53_23651856_ChIP-Seq_MEFs_Mouse1.30305751
94STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29255061
95* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.27831816
96PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26858942
97SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.26816382
98POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.26750492
99* RNF2_27304074_Chip-Seq_ESCs_Mouse1.26452594
100RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.26065109
101GATA3_27048872_Chip-Seq_THYMUS_Human1.25315667
102NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25265339
103SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25246835
104NFIB_24661679_ChIP-Seq_LUNG_Mouse1.25147417
105NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24836280
106NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24836280
107TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.23791185
108KDM2B_26808549_Chip-Seq_K562_Human1.23719457
109MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.23320549
110RUNX1_22412390_ChIP-Seq_EML_Mouse1.22146569
111SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.21845062
112SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21635253
113* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.21579770
114* VDR_24787735_ChIP-Seq_THP-1_Human1.21056887
115* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19798991
116MAF_26560356_Chip-Seq_TH2_Human1.19741403
117SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18498082
118SALL4_18804426_ChIP-ChIP_XEN_Mouse1.17903351
119AR_21909140_ChIP-Seq_LNCAP_Human1.17840469
120NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.17792380
121ISL1_27105846_Chip-Seq_CPCs_Mouse1.16970106
122BRD4_27068464_Chip-Seq_AML-cells_Mouse1.15773568
123THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15128354
124TP53_20018659_ChIP-ChIP_R1E_Mouse1.14912789
125EZH2_27304074_Chip-Seq_ESCs_Mouse1.14016192
126DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.13517316
127* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13258096
128ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12882485
129* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12704027
130* SMRT_27268052_Chip-Seq_Bcells_Human1.12640766
131ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11303113
132WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10572606
133JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10307797
134NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.10251941
135SMC1_22415368_ChIP-Seq_MEFs_Mouse1.10056878
136ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09327902
137GATA2_21666600_ChIP-Seq_HMVEC_Human1.08218402
138CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07822937
139* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.06391181
140* RING1B_27294783_Chip-Seq_NPCs_Mouse1.06226546
141JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06012152
142OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04551999
143ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04426787
144KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04039284
145GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02529338
146RACK7_27058665_Chip-Seq_MCF-7_Human1.01676949
147KDM2B_26808549_Chip-Seq_JURKAT_Human1.00996652
148YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00110095
149ATF3_27146783_Chip-Seq_COLON_Human0.99682346
150RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.99512878
151GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98816159
152CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92746422
153* PU_27001747_Chip-Seq_BMDM_Mouse0.91511438
154FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.90080134
155MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.87140841
156SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82026428
157GATA3_26560356_Chip-Seq_TH2_Human0.82010817
158LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.81603304
159GATA3_26560356_Chip-Seq_TH1_Human0.81182372
160FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78519200
161* ELK3_25401928_ChIP-Seq_HUVEC_Human0.78472898
162GATA1_19941827_ChIP-Seq_MEL_Mouse0.74196527
163GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.73234547
164Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.72829864
165FOXO3_23340844_ChIP-Seq_DLD1_Human0.72319352
166TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72010193
167MYB_21317192_ChIP-Seq_ERMYB_Mouse0.71445431
168* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.69024795
169RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.67689002
170STAT6_21828071_ChIP-Seq_BEAS2B_Human0.67088063
171ZFP281_27345836_Chip-Seq_ESCs_Mouse0.66448050
172AR_21572438_ChIP-Seq_LNCaP_Human0.66025370
173NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.65245214
174FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.65013813
175TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.64827141
176GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63642647
177GATA1_22383799_ChIP-Seq_G1ME_Mouse0.63315664
178EWS_26573619_Chip-Seq_HEK293_Human0.61862577
179GATA1_19941826_ChIP-Seq_K562_Human0.58996703
180TAF15_26573619_Chip-Seq_HEK293_Human0.58584908
181RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.58445579
182TCF4_18268006_ChIP-ChIP_LS174T_Human0.58230719
183HOXB4_20404135_ChIP-ChIP_EML_Mouse0.57485150
184POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.57304406
185TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.57304406
186CTNNB1_20460455_ChIP-Seq_HCT116_Human0.57194364
187VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.57119374
188ERG_20887958_ChIP-Seq_HPC-7_Mouse0.55827316
189E2F1_21310950_ChIP-Seq_MCF-7_Human0.55486689
190BP1_19119308_ChIP-ChIP_Hs578T_Human0.54909262
191NFE2_27457419_Chip-Seq_LIVER_Mouse0.54673364
192P300_27268052_Chip-Seq_Bcells_Human0.54463563

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.37060346
2MP0001800_abnormal_humoral_immune5.08027634
3MP0005387_immune_system_phenotype4.95961610
4MP0001790_abnormal_immune_system4.95961610
5MP0001835_abnormal_antigen_presentation4.59091410
6MP0004272_abnormal_basement_membrane4.05982801
7MP0003705_abnormal_hypodermis_morpholog3.88856630
8MP0002452_abnormal_antigen_presenting3.75910841
9MP0000685_abnormal_immune_system3.49126191
10MP0002723_abnormal_immune_serum3.07425875
11MP0005623_abnormal_meninges_morphology2.98481908
12MP0002398_abnormal_bone_marrow2.96759087
13MP0002420_abnormal_adaptive_immunity2.96712003
14MP0005275_abnormal_skin_tensile2.96487528
15MP0003303_peritoneal_inflammation2.93925761
16MP0005000_abnormal_immune_tolerance2.92339663
17MP0001819_abnormal_immune_cell2.88059118
18MP0002396_abnormal_hematopoietic_system2.83107222
19MP0003566_abnormal_cell_adhesion2.75890615
20* MP0000716_abnormal_immune_system2.67271488
21MP0001958_emphysema2.65960526
22MP0000689_abnormal_spleen_morphology2.65427105
23MP0005671_abnormal_response_to2.60344383
24MP0003279_aneurysm2.52697056
25MP0010368_abnormal_lymphatic_system2.49707451
26MP0005503_abnormal_tendon_morphology2.36829615
27MP0010030_abnormal_orbit_morphology2.25007030
28MP0002722_abnormal_immune_system2.20834873
29MP0000579_abnormal_nail_morphology2.11564335
30* MP0002429_abnormal_blood_cell2.10081680
31MP0003950_abnormal_plasma_membrane2.07856247
32MP0000751_myopathy2.06321389
33MP0008057_abnormal_DNA_replication2.06089326
34MP0000762_abnormal_tongue_morphology2.03758825
35MP0005645_abnormal_hypothalamus_physiol2.01355883
36MP0009384_cardiac_valve_regurgitation1.97181189
37MP0000703_abnormal_thymus_morphology1.92735075
38MP0004858_abnormal_nervous_system1.92592631
39MP0000013_abnormal_adipose_tissue1.87991670
40MP0005023_abnormal_wound_healing1.86275730
41MP0003763_abnormal_thymus_physiology1.83435660
42MP0001299_abnormal_eye_distance/1.80106937
43MP0000537_abnormal_urethra_morphology1.79990235
44MP0002060_abnormal_skin_morphology1.78926740
45MP0002877_abnormal_melanocyte_morpholog1.77484106
46MP0003941_abnormal_skin_development1.77423673
47MP0004808_abnormal_hematopoietic_stem1.75700415
48MP0002166_altered_tumor_susceptibility1.74670750
49MP0005025_abnormal_response_to1.72207114
50MP0009053_abnormal_anal_canal1.67336270
51MP0003283_abnormal_digestive_organ1.67222190
52MP0005310_abnormal_salivary_gland1.65237827
53MP0001879_abnormal_lymphatic_vessel1.64389252
54MP0002419_abnormal_innate_immunity1.62134204
55MP0003787_abnormal_imprinting1.59406968
56MP0002896_abnormal_bone_mineralization1.58556471
57MP0000534_abnormal_ureter_morphology1.55011198
58MP0001849_ear_inflammation1.53779685
59MP0009785_altered_susceptibility_to1.53054511
60MP0005508_abnormal_skeleton_morphology1.52883765
61MP0000749_muscle_degeneration1.45915032
62MP0003385_abnormal_body_wall1.45171289
63MP0009780_abnormal_chondrocyte_physiolo1.44175545
64MP0002148_abnormal_hypersensitivity_rea1.43148429
65MP0003436_decreased_susceptibility_to1.39341719
66MP0009250_abnormal_appendicular_skeleto1.38920481
67MP0006054_spinal_hemorrhage1.35970584
68MP0001986_abnormal_taste_sensitivity1.34275419
69MP0002933_joint_inflammation1.32957361
70MP0009278_abnormal_bone_marrow1.29258901
71MP0002405_respiratory_system_inflammati1.29117242
72MP0010094_abnormal_chromosome_stability1.28369504
73MP0004233_abnormal_muscle_weight1.27185253
74MP0005257_abnormal_intraocular_pressure1.27138150
75MP0003300_gastrointestinal_ulcer1.25352028
76MP0005595_abnormal_vascular_smooth1.20958520
77MP0005171_absent_coat_pigmentation1.20802410
78MP0001845_abnormal_inflammatory_respons1.20604724
79MP0000462_abnormal_digestive_system1.20588440
80MP0003183_abnormal_peptide_metabolism1.18485605
81MP0010155_abnormal_intestine_physiology1.18130621
82MP0003755_abnormal_palate_morphology1.17609914
83MP0000467_abnormal_esophagus_morphology1.16893818
84MP0000428_abnormal_craniofacial_morphol1.16255512
85MP0002697_abnormal_eye_size1.15466279
86MP0003942_abnormal_urinary_system1.15095638
87MP0000920_abnormal_myelination1.14851947
88MP0003045_fibrosis1.14842233
89MP0002108_abnormal_muscle_morphology1.14527568
90MP0001873_stomach_inflammation1.13819562
91MP0000465_gastrointestinal_hemorrhage1.13610102
92MP0002006_tumorigenesis1.13409690
93MP0003077_abnormal_cell_cycle1.12424680
94MP0002089_abnormal_postnatal_growth/wei1.12300290
95MP0004084_abnormal_cardiac_muscle1.10938381
96MP0010352_gastrointestinal_tract_polyps1.10005519
97MP0004510_myositis1.09985676
98MP0005197_abnormal_uvea_morphology1.09822961
99MP0000003_abnormal_adipose_tissue1.09448305
100MP0003866_abnormal_defecation1.07500834
101MP0002295_abnormal_pulmonary_circulatio1.06503578
102MP0004947_skin_inflammation1.03011182
103MP0002019_abnormal_tumor_incidence1.02844326
104MP0006138_congestive_heart_failure1.00630653
105MP0001542_abnormal_bone_strength1.00028374
106MP0000432_abnormal_head_morphology0.95681502
107MP0004087_abnormal_muscle_fiber0.94482795
108MP0003111_abnormal_nucleus_morphology0.94183679
109MP0000759_abnormal_skeletal_muscle0.93620851
110MP0002277_abnormal_respiratory_mucosa0.92330047
111MP0003935_abnormal_craniofacial_develop0.92156880
112MP0003937_abnormal_limbs/digits/tail_de0.90162495
113MP0002095_abnormal_skin_pigmentation0.89954085
114MP0005464_abnormal_platelet_physiology0.89707967
115MP0002233_abnormal_nose_morphology0.88804770
116MP0005451_abnormal_body_composition0.88148112
117MP0000778_abnormal_nervous_system0.87952253
118MP0004134_abnormal_chest_morphology0.86505375
119MP0002269_muscular_atrophy0.86131896
120MP0003115_abnormal_respiratory_system0.85720130
121MP0000049_abnormal_middle_ear0.85240455
122MP0001915_intracranial_hemorrhage0.85191546
123MP0008874_decreased_physiological_sensi0.84577139
124MP0005076_abnormal_cell_differentiation0.84311390
125MP0000569_abnormal_digit_pigmentation0.84004410
126MP0000750_abnormal_muscle_regeneration0.82877321
127MP0004742_abnormal_vestibular_system0.81809190
128MP0002282_abnormal_trachea_morphology0.81095163
129MP0004885_abnormal_endolymph0.79996088
130MP0005193_abnormal_anterior_eye0.79888192
131MP0000163_abnormal_cartilage_morphology0.79763892
132MP0000747_muscle_weakness0.78893745
133MP0003091_abnormal_cell_migration0.78839917
134MP0002116_abnormal_craniofacial_bone0.78787971
135MP0001243_abnormal_dermal_layer0.78198602
136MP0002928_abnormal_bile_duct0.77707644
137MP0009333_abnormal_splenocyte_physiolog0.76816947
138MP0003634_abnormal_glial_cell0.76688501
139MP0002234_abnormal_pharynx_morphology0.76321464
140MP0005330_cardiomyopathy0.76034490
141MP0002932_abnormal_joint_morphology0.75545365
142MP0001614_abnormal_blood_vessel0.75241162
143MP0001661_extended_life_span0.74762630
144MP0002128_abnormal_blood_circulation0.74455906
145MP0002092_abnormal_eye_morphology0.73877997
146MP0002925_abnormal_cardiovascular_devel0.71888045
147MP0005620_abnormal_muscle_contractility0.71715713
148MP0006292_abnormal_olfactory_placode0.71683287
149MP0010771_integument_phenotype0.71149987
150MP0002136_abnormal_kidney_physiology0.70495482
151MP0003646_muscle_fatigue0.69132600
152MP0008058_abnormal_DNA_repair0.69073059
153MP0002114_abnormal_axial_skeleton0.68888710
154MP0000015_abnormal_ear_pigmentation0.68783997
155MP0002249_abnormal_larynx_morphology0.67085690
156MP0008877_abnormal_DNA_methylation0.66944491
157MP0003329_amyloid_beta_deposits0.66505483
158MP0001348_abnormal_lacrimal_gland0.65623746
159MP0000733_abnormal_muscle_development0.65578432
160MP0002163_abnormal_gland_morphology0.65351533
161MP0005248_abnormal_Harderian_gland0.64908381
162MP0000566_synostosis0.64637360
163MP0003878_abnormal_ear_physiology0.64459310
164MP0005377_hearing/vestibular/ear_phenot0.64459310
165MP0001340_abnormal_eyelid_morphology0.64378262
166MP0000350_abnormal_cell_proliferation0.64344369
167MP0000490_abnormal_crypts_of0.63853091
168MP0002132_abnormal_respiratory_system0.63168077
169MP0001784_abnormal_fluid_regulation0.62896075
170MP0002115_abnormal_skeleton_extremities0.62781754
171MP0005409_darkened_coat_color0.60459314
172MP0000383_abnormal_hair_follicle0.60288311
173MP0008004_abnormal_stomach_pH0.54739234
174MP0002998_abnormal_bone_remodeling0.52869016
175MP0005621_abnormal_cell_physiology0.51432002
176MP0003453_abnormal_keratinocyte_physiol0.51042306
177MP0006082_CNS_inflammation0.50105665
178MP0008260_abnormal_autophagy0.49679329
179MP0001853_heart_inflammation0.48997682
180MP0010678_abnormal_skin_adnexa0.48051229
181MP0000470_abnormal_stomach_morphology0.47363310
182MP0000767_abnormal_smooth_muscle0.47344628
183MP0000313_abnormal_cell_death0.46938530
184MP0003690_abnormal_glial_cell0.46385817
185MP0005501_abnormal_skin_physiology0.46193226
186MP0003943_abnormal_hepatobiliary_system0.45836194
187MP0005174_abnormal_tail_pigmentation0.43815013
188MP0001346_abnormal_lacrimal_gland0.43342724

Predicted human phenotypes

RankGene SetZ-score
1Cellulitis (HP:0100658)7.64852771
2Verrucae (HP:0200043)6.73546176
3Papilloma (HP:0012740)6.73546176
4Gastrointestinal stroma tumor (HP:0100723)5.98165717
5Premature rupture of membranes (HP:0001788)5.80330811
6Protrusio acetabuli (HP:0003179)5.71371353
7Recurrent sinusitis (HP:0011108)5.48774047
8Recurrent bronchitis (HP:0002837)5.46019616
9Chronic sinusitis (HP:0011109)5.40350452
10Colitis (HP:0002583)5.10517414
11Thyroiditis (HP:0100646)4.96973403
12Meningitis (HP:0001287)4.96891960
13Atrophic scars (HP:0001075)4.86939639
14B lymphocytopenia (HP:0010976)4.85522584
15Abnormality of B cell number (HP:0010975)4.85522584
16Panhypogammaglobulinemia (HP:0003139)4.84359632
17Recurrent pneumonia (HP:0006532)4.73397282
18Recurrent viral infections (HP:0004429)4.69642464
19Osteomyelitis (HP:0002754)4.61132580
20Inflammation of the large intestine (HP:0002037)4.46959656
21Chronic otitis media (HP:0000389)4.45896475
22Lymphopenia (HP:0001888)4.39123141
23Gastrointestinal inflammation (HP:0004386)4.29335961
24Abnormality of cells of the lymphoid lineage (HP:0012140)4.16419397
25Recurrent lower respiratory tract infections (HP:0002783)4.12541915
26Sepsis (HP:0100806)4.08716836
27Recurrent otitis media (HP:0000403)3.93207264
28IgM deficiency (HP:0002850)3.87524866
29Vascular tortuosity (HP:0004948)3.83640059
30Arterial tortuosity (HP:0005116)3.75232642
31Aortic dissection (HP:0002647)3.71908575
32Abnormal delayed hypersensitivity skin test (HP:0002963)3.57310814
33Fragile skin (HP:0001030)3.49341838
34Emphysema (HP:0002097)3.47731669
35Neonatal short-limb short stature (HP:0008921)3.36230794
36Ankle contracture (HP:0006466)3.35225986
37Shallow orbits (HP:0000586)3.33559093
38Bladder diverticulum (HP:0000015)3.25032185
39Aortic aneurysm (HP:0004942)3.24857550
40Recurrent fungal infections (HP:0002841)3.24325643
41Abnormality of the fingertips (HP:0001211)3.23841216
42Abnormality of dentin (HP:0010299)3.13270962
43Spinal rigidity (HP:0003306)3.11395495
44Vasculitis (HP:0002633)3.09598760
45Chronic mucocutaneous candidiasis (HP:0002728)3.05079880
46Recurrent cutaneous fungal infections (HP:0011370)3.05079880
47Wormian bones (HP:0002645)3.03705305
48Soft skin (HP:0000977)3.02646636
49Bronchitis (HP:0012387)2.94412647
50Restrictive lung disease (HP:0002091)2.92865503
51Cervical subluxation (HP:0003308)2.85083835
52IgG deficiency (HP:0004315)2.82044246
53Severe combined immunodeficiency (HP:0004430)2.78868022
54Parakeratosis (HP:0001036)2.74787761
55Short nail (HP:0001799)2.74706750
56Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.70977399
57T lymphocytopenia (HP:0005403)2.69481132
58Follicular hyperkeratosis (HP:0007502)2.65347714
59Skin rash (HP:0000988)2.58505075
60Abnormality of T cell number (HP:0011839)2.55914788
61Vertebral compression fractures (HP:0002953)2.51610430
62Combined immunodeficiency (HP:0005387)2.51366899
63Type 1 muscle fiber predominance (HP:0003803)2.49491254
64IgA deficiency (HP:0002720)2.48863542
65Genu recurvatum (HP:0002816)2.46602968
66Broad metatarsal (HP:0001783)2.45248221
67Recurrent abscess formation (HP:0002722)2.45205511
68Recurrent bacterial skin infections (HP:0005406)2.43113582
69Cerebral aneurysm (HP:0004944)2.40171627
70Recurrent skin infections (HP:0001581)2.39845564
71Long eyelashes (HP:0000527)2.39185881
72Mitral valve prolapse (HP:0001634)2.34923597
73Lymphoma (HP:0002665)2.34362793
74Neutropenia (HP:0001875)2.33185708
75Blue sclerae (HP:0000592)2.32776638
76Leukopenia (HP:0001882)2.30205425
77Natal tooth (HP:0000695)2.29907525
78Coronal craniosynostosis (HP:0004440)2.29448558
79Hyperacusis (HP:0010780)2.28956137
80* Mitral regurgitation (HP:0001653)2.28665678
81Pterygium (HP:0001059)2.27810139
82Hypoplasia of the thymus (HP:0000778)2.26266299
83* Abnormality of the intervertebral disk (HP:0005108)2.24562009
84Milia (HP:0001056)2.24053970
85Osteolytic defects of the hand bones (HP:0009699)2.21877045
86Osteolytic defects of the phalanges of the hand (HP:0009771)2.21877045
87* Ulnar bowing (HP:0003031)2.20429877
88Aqueductal stenosis (HP:0002410)2.19027119
89Bowel diverticulosis (HP:0005222)2.16387877
90Increased variability in muscle fiber diameter (HP:0003557)2.15692232
91Viral hepatitis (HP:0006562)2.15564094
92Hyperextensible skin (HP:0000974)2.14342469
93Joint laxity (HP:0001388)2.14314452
94Skin ulcer (HP:0200042)2.13346966
95Dehydration (HP:0001944)2.13094035
96Abnormality of T cells (HP:0002843)2.12036770
97Ectopic kidney (HP:0000086)2.11421718
98Eosinophilia (HP:0001880)2.10198089
99Mediastinal lymphadenopathy (HP:0100721)2.10090651
100Wide anterior fontanel (HP:0000260)2.09701766
101Elbow flexion contracture (HP:0002987)2.07776879
102External ear malformation (HP:0008572)2.07763610
103Obstructive lung disease (HP:0006536)2.06247884
104Chronic obstructive pulmonary disease (HP:0006510)2.06247884
105Biconcave vertebral bodies (HP:0004586)2.05458343
106Broad face (HP:0000283)2.01896632
107Spondylolisthesis (HP:0003302)2.01453827
108Renal duplication (HP:0000075)2.00744028
109Agammaglobulinemia (HP:0004432)10.8868150
110Mildly elevated creatine phosphokinase (HP:0008180)1.99425714
111Erythroderma (HP:0001019)1.97168945
112Increased connective tissue (HP:0009025)1.96881568
113Aplasia involving bones of the upper limbs (HP:0009823)1.96222377
114Aplasia of the phalanges of the hand (HP:0009802)1.96222377
115Aplasia involving bones of the extremities (HP:0009825)1.96222377
116Wrist flexion contracture (HP:0001239)1.95795736
117Dilatation of the ascending aorta (HP:0005111)1.95533896
118Cheilitis (HP:0100825)1.94067997
119Hypoplasia of the iris (HP:0007676)1.93782942
120* Small epiphyses (HP:0010585)1.93260047
121Absent frontal sinuses (HP:0002688)1.92023323
122Overgrowth (HP:0001548)1.91504614
123Turricephaly (HP:0000262)1.90205900
124Chronic diarrhea (HP:0002028)1.88780766
125Abnormality of the acetabulum (HP:0003170)1.86729939
126Spontaneous hematomas (HP:0007420)1.84657590
127Encephalitis (HP:0002383)1.84198202
128Volvulus (HP:0002580)1.83904038
129Abnormality of eosinophils (HP:0001879)1.82950474
130Arnold-Chiari malformation (HP:0002308)1.82536011
131Distal upper limb amyotrophy (HP:0007149)1.81639425
132Upper limb amyotrophy (HP:0009129)1.81639425
133Thin ribs (HP:0000883)1.80680877
134Round ear (HP:0100830)1.80551785
135Abnormality of skeletal muscle fiber size (HP:0012084)1.76451816
136Right ventricular cardiomyopathy (HP:0011663)1.76401463
137Fragile nails (HP:0001808)1.75840183
138Abnormal delivery (HP:0001787)1.75693010
139Hallux valgus (HP:0001822)1.75114579
140Knee flexion contracture (HP:0006380)1.74974217
141Deviation of the hallux (HP:0010051)1.74972596
142Pulmonary artery stenosis (HP:0004415)1.74753418
143Autoimmune thrombocytopenia (HP:0001973)1.73614439
144Ectopia lentis (HP:0001083)1.71508957
145Abnormality of T cell physiology (HP:0011840)1.70695425
146Ectropion (HP:0000656)1.70533957
147* Aortic regurgitation (HP:0001659)1.69762211
148Insomnia (HP:0100785)1.69543513
149Breech presentation (HP:0001623)1.68406871
150Back pain (HP:0003418)1.68029855
151Coxa vara (HP:0002812)1.67162482
152Mild short stature (HP:0003502)1.66965760
153Generalized amyotrophy (HP:0003700)1.66235319
154Granulocytopenia (HP:0001913)1.65931994
155Popliteal pterygium (HP:0009756)1.65261366
156Xerostomia (HP:0000217)1.65066944
157Abnormality of the distal phalanx of the thumb (HP:0009617)1.64435654
158Peritonitis (HP:0002586)1.64155305
159Advanced eruption of teeth (HP:0006288)1.63888503
160Protruding ear (HP:0000411)1.63198161
161Limb-girdle muscle weakness (HP:0003325)1.63154611
162Aplasia/Hypoplasia of the thymus (HP:0010515)1.62563623
163Slender build (HP:0001533)1.62431807
164Abnormality of the calcaneus (HP:0008364)1.62221990
165Aneurysm (HP:0002617)1.62128062
166Disproportionate tall stature (HP:0001519)1.60898545
167Flat cornea (HP:0007720)1.60794128
168Camptodactyly of toe (HP:0001836)1.59403706
169* Tibial bowing (HP:0002982)1.58814794
170Onycholysis (HP:0001806)1.58586519
171Cutis marmorata (HP:0000965)1.56971382
172Elfin facies (HP:0004428)1.56008640
173Hypoventilation (HP:0002791)1.54931941
174Spinal cord lesions (HP:0100561)1.54859902
175Syringomyelia (HP:0003396)1.54859902
176Venous abnormality (HP:0002624)1.54040280
177Congenital glaucoma (HP:0001087)1.54026421
178Dislocated radial head (HP:0003083)1.53674685
179Inguinal hernia (HP:0000023)1.53286608
180Increased IgE level (HP:0003212)1.52429396
181Chromosomal breakage induced by crosslinking agents (HP:0003221)1.51602157
182Tented upper lip vermilion (HP:0010804)1.51280652
183Chromsome breakage (HP:0040012)1.49496887
184Unilateral renal agenesis (HP:0000122)1.49000131
185Fatigue (HP:0012378)1.48837447
186Abnormality of the thymus (HP:0000777)1.47424072
187Hematochezia (HP:0002573)1.47254153
188Interstitial pulmonary disease (HP:0006530)1.43486067
189Abnormality of incisor morphology (HP:0011063)1.43252737
190Pustule (HP:0200039)1.42611778
191Macroorchidism (HP:0000053)1.42358542
192Duplicated collecting system (HP:0000081)1.41474090
193Abnormality of chromosome segregation (HP:0002916)1.40117474
194Acute lymphatic leukemia (HP:0006721)1.39607552
195Congenital stationary night blindness (HP:0007642)1.38783996
196Hypoproteinemia (HP:0003075)1.35340427
197Blepharitis (HP:0000498)1.34977411
198Bronchiectasis (HP:0002110)1.34058156
199Clubbing of toes (HP:0100760)1.33838397
200Eczematoid dermatitis (HP:0000976)1.33662300

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K106.34070158
2MAP4K14.61983471
3LMTK23.78472312
4SIK23.64527735
5PDGFRA3.46019045
6EPHB23.40439502
7TTN3.34884806
8GRK63.26899964
9NTRK13.11859466
10SIK32.93912796
11LATS22.78217434
12MET2.62838827
13PTK22.48467047
14MYLK2.45720356
15CDK122.44025603
16DDR22.34826314
17SYK2.34464879
18ERN12.31465388
19EEF2K2.29784625
20BLK2.27689943
21CSF1R2.26355176
22RIPK12.21719414
23LATS12.20397859
24EPHA22.20150948
25RIPK42.16702237
26BTK2.14256013
27TRIB32.13690640
28MST1R2.03884181
29SIK11.98883945
30STK101.93047797
31MARK31.83673294
32CLK11.80710645
33PAK21.80255766
34LIMK11.74416434
35NEK91.70064127
36MOS1.68827434
37ERBB41.55613489
38MAP3K141.54018881
39PAK41.54005068
40LYN1.53471177
41WNK11.49894500
42STK41.44675314
43FES1.42764474
44TESK11.42761812
45PDGFRB1.42448102
46MAP3K131.41693501
47PRKD31.34624523
48PAK61.33352019
49LRRK21.31842644
50TNK21.30981672
51DMPK1.29881726
52BRD41.28114353
53HCK1.27890724
54ROCK11.25012282
55FGFR21.23682599
56MARK11.20201202
57STK381.19931269
58ARAF1.19547422
59NEK21.13933111
60CSK1.12598472
61CAMK1G1.11546514
62GRK11.10946495
63MTOR1.10275612
64JAK11.08577065
65PKN11.06747644
66STK38L1.06035054
67CDK81.03416750
68EPHB10.99975887
69MAPK70.99875187
70TYK20.99730808
71TLK10.99267388
72PIM10.98461058
73PRPF4B0.98148697
74CDK40.97428662
75PIM20.96266835
76MUSK0.92960997
77MARK20.92600177
78IKBKB0.88460790
79ITK0.87995435
80LCK0.87341888
81PRKD20.86074685
82MST40.85769780
83CDK90.85708306
84PRKCQ0.85265051
85PNCK0.83675595
86CAMK1D0.82679233
87ILK0.81146364
88MAPK120.77670689
89EIF2AK30.77128361
90MELK0.76586750
91PRKG20.76203206
92CASK0.75553669
93RPS6KA20.72829980
94ABL20.72570849
95HIPK20.71830821
96TEC0.71174610
97STK30.71085803
98CSNK1D0.70467794
99MAPK130.70362070
100FGR0.70332964
101IRAK30.69817763
102FLT30.69515346
103FGFR30.67014358
104MAPK110.66176827
105KSR10.63805092
106PRKD10.63546305
107IRAK40.62448474
108NLK0.62024300
109PKN20.61619762
110GSK3A0.61310285
111PRKCH0.61183031
112TYRO30.60856555
113CAMK2G0.60631750
114TRPM70.60032363
115CAMK2D0.58688243
116MAP3K60.58444361
117SMG10.58250374
118RPS6KB20.57846075
119MAPK40.56932138
120AKT30.56781342
121FYN0.55261190
122CAMK2B0.54420354
123KSR20.54259897
124ABL10.54187749
125BMX0.51329532
126MAP3K70.50536122
127PHKG10.50191535
128PHKG20.50191535
129SGK30.49228423
130INSR0.49220782
131FRK0.48753420
132CHEK10.48726872
133ALK0.48083085
134CSNK1A1L0.47664017
135BCR0.47070864
136FGFR10.46076967
137PTK60.45654222
138CHUK0.45500816
139JAK30.44876783
140ZAK0.44768583
141IKBKE0.44391810
142CHEK20.44050774
143MAP3K30.43996370
144FER0.42159232
145MAP3K90.41525033
146TBK10.41441391
147AKT20.40417858
148CDC42BPA0.40188808
149KIT0.39827537
150CDC70.38758533
151FGFR40.38497202
152NTRK20.38477751
153TAOK20.37518970
154DYRK1B0.37349303
155RPS6KA50.36907113
156PBK0.36210589
157TGFBR20.36118242
158MKNK20.36107819
159CSNK1G10.35694070
160DAPK30.35108701
161MAP2K10.35082380
162PRKCE0.34297209
163YES10.34059522
164ATR0.33370312
165EPHA30.30564388
166SGK20.30537824
167CDK150.30400127
168TGFBR10.30172421
169CDK180.29109988
170RPS6KB10.28091025
171RET0.26817458
172ICK0.26637053
173SRC0.26320887
174CDK11A0.26131823
175MAP3K80.26116575
176MATK0.26026836
177CDK20.25733447
178PRKAA10.25691684
179PDK10.24713593
180ROCK20.24308094
181CDK30.22744676

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.11852830
2B cell receptor signaling pathway_Homo sapiens_hsa046625.48832434
3ECM-receptor interaction_Homo sapiens_hsa045123.89055475
4Focal adhesion_Homo sapiens_hsa045102.81123151
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.77312923
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.71429998
7Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.60186588
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.50164016
9Non-homologous end-joining_Homo sapiens_hsa034502.42171458
10* Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.34305110
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.31434625
12Dilated cardiomyopathy_Homo sapiens_hsa054142.30434009
13Hematopoietic cell lineage_Homo sapiens_hsa046402.26952810
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.18462579
15Adherens junction_Homo sapiens_hsa045202.05919022
16Hippo signaling pathway_Homo sapiens_hsa043901.97744497
17Osteoclast differentiation_Homo sapiens_hsa043801.90824709
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.82237160
19Protein digestion and absorption_Homo sapiens_hsa049741.65927773
20Basal cell carcinoma_Homo sapiens_hsa052171.60756248
21T cell receptor signaling pathway_Homo sapiens_hsa046601.49324449
22TGF-beta signaling pathway_Homo sapiens_hsa043501.48135557
23Amoebiasis_Homo sapiens_hsa051461.47690497
24Hedgehog signaling pathway_Homo sapiens_hsa043401.45636871
25Non-small cell lung cancer_Homo sapiens_hsa052231.42970859
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.42802406
27Chemokine signaling pathway_Homo sapiens_hsa040621.39403017
28Measles_Homo sapiens_hsa051621.37606659
29Central carbon metabolism in cancer_Homo sapiens_hsa052301.35771714
30Transcriptional misregulation in cancer_Homo sapiens_hsa052021.35730530
31Systemic lupus erythematosus_Homo sapiens_hsa053221.34218676
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.33710192
33Base excision repair_Homo sapiens_hsa034101.32418448
34Tight junction_Homo sapiens_hsa045301.29504951
35Leishmaniasis_Homo sapiens_hsa051401.27705898
36Chronic myeloid leukemia_Homo sapiens_hsa052201.26615275
37Bladder cancer_Homo sapiens_hsa052191.24495886
38Prion diseases_Homo sapiens_hsa050201.22695344
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.20739081
40Pancreatic cancer_Homo sapiens_hsa052121.20280810
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.17673197
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16318326
43Melanogenesis_Homo sapiens_hsa049161.15031214
44Herpes simplex infection_Homo sapiens_hsa051681.14587651
45Tuberculosis_Homo sapiens_hsa051521.12381388
46Viral carcinogenesis_Homo sapiens_hsa052031.11497546
47MicroRNAs in cancer_Homo sapiens_hsa052061.11219890
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.11175613
49Leukocyte transendothelial migration_Homo sapiens_hsa046701.09914377
50Gap junction_Homo sapiens_hsa045401.08447215
51Melanoma_Homo sapiens_hsa052181.07801302
52Epstein-Barr virus infection_Homo sapiens_hsa051691.05260808
53Wnt signaling pathway_Homo sapiens_hsa043101.04640003
54Platelet activation_Homo sapiens_hsa046111.04078711
55Antigen processing and presentation_Homo sapiens_hsa046121.03194193
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.01979334
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.00918048
58Glioma_Homo sapiens_hsa052140.98031466
59Hepatitis B_Homo sapiens_hsa051610.97254289
60Renal cell carcinoma_Homo sapiens_hsa052110.96825047
61Steroid biosynthesis_Homo sapiens_hsa001000.95354325
62NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94542277
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.94236476
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.93664663
65Lysine degradation_Homo sapiens_hsa003100.92298280
66Endometrial cancer_Homo sapiens_hsa052130.89275215
67Acute myeloid leukemia_Homo sapiens_hsa052210.89213385
68Prostate cancer_Homo sapiens_hsa052150.87288724
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85782513
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.85439182
71Alcoholism_Homo sapiens_hsa050340.84767156
72FoxO signaling pathway_Homo sapiens_hsa040680.84607571
73HTLV-I infection_Homo sapiens_hsa051660.83813386
74Choline metabolism in cancer_Homo sapiens_hsa052310.82951317
75Rap1 signaling pathway_Homo sapiens_hsa040150.82802477
76Inositol phosphate metabolism_Homo sapiens_hsa005620.81910605
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81587925
78Shigellosis_Homo sapiens_hsa051310.80456623
79ErbB signaling pathway_Homo sapiens_hsa040120.78497537
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78202948
81Estrogen signaling pathway_Homo sapiens_hsa049150.77674014
82Small cell lung cancer_Homo sapiens_hsa052220.77644820
83Toxoplasmosis_Homo sapiens_hsa051450.76594991
84Thyroid hormone synthesis_Homo sapiens_hsa049180.76427042
85Homologous recombination_Homo sapiens_hsa034400.75964574
86Notch signaling pathway_Homo sapiens_hsa043300.75286896
87Vitamin B6 metabolism_Homo sapiens_hsa007500.74735852
88Vibrio cholerae infection_Homo sapiens_hsa051100.74431694
89Influenza A_Homo sapiens_hsa051640.74156921
90Fanconi anemia pathway_Homo sapiens_hsa034600.74146523
91Bile secretion_Homo sapiens_hsa049760.73983010
92Apoptosis_Homo sapiens_hsa042100.73861010
93Thyroid cancer_Homo sapiens_hsa052160.73598035
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.72003771
95MAPK signaling pathway_Homo sapiens_hsa040100.71996120
96AMPK signaling pathway_Homo sapiens_hsa041520.71444495
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71187957
98Phototransduction_Homo sapiens_hsa047440.69418930
99Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.69085550
100Circadian rhythm_Homo sapiens_hsa047100.68225120
101mRNA surveillance pathway_Homo sapiens_hsa030150.67988045
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67771698
103Gastric acid secretion_Homo sapiens_hsa049710.67625668
104N-Glycan biosynthesis_Homo sapiens_hsa005100.66912756
105Galactose metabolism_Homo sapiens_hsa000520.64253708
106Malaria_Homo sapiens_hsa051440.63835607
107Dorso-ventral axis formation_Homo sapiens_hsa043200.62570596
108African trypanosomiasis_Homo sapiens_hsa051430.62480002
109Insulin signaling pathway_Homo sapiens_hsa049100.62270377
110Spliceosome_Homo sapiens_hsa030400.61800479
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61578069
112Ovarian steroidogenesis_Homo sapiens_hsa049130.61282462
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60816683
114Axon guidance_Homo sapiens_hsa043600.60743893
115mTOR signaling pathway_Homo sapiens_hsa041500.60397897
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.60385623
117Morphine addiction_Homo sapiens_hsa050320.60278011
118Type II diabetes mellitus_Homo sapiens_hsa049300.59620555
119Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59587295
120Hepatitis C_Homo sapiens_hsa051600.58439065
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58173938
122Cell cycle_Homo sapiens_hsa041100.57552293
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57287584
124Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56941073
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56538443
126Mismatch repair_Homo sapiens_hsa034300.56428429
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56408609
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56291939
129GnRH signaling pathway_Homo sapiens_hsa049120.56275827
130Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55702766
131Glucagon signaling pathway_Homo sapiens_hsa049220.55310583
132Colorectal cancer_Homo sapiens_hsa052100.54837316
133VEGF signaling pathway_Homo sapiens_hsa043700.54056513
134TNF signaling pathway_Homo sapiens_hsa046680.53329684
135Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53041464
136Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52190538
137p53 signaling pathway_Homo sapiens_hsa041150.51021678
138Cocaine addiction_Homo sapiens_hsa050300.50669412
139Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50328708
140cAMP signaling pathway_Homo sapiens_hsa040240.50303226
141Ras signaling pathway_Homo sapiens_hsa040140.50201989
142Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49461251
143Renin secretion_Homo sapiens_hsa049240.49390251
144Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48529845
145Sphingolipid signaling pathway_Homo sapiens_hsa040710.48070180
146Endocytosis_Homo sapiens_hsa041440.46767364
147Viral myocarditis_Homo sapiens_hsa054160.45645034
148Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44159363
149Olfactory transduction_Homo sapiens_hsa047400.43544844
150Pathways in cancer_Homo sapiens_hsa052000.42832761
151Basal transcription factors_Homo sapiens_hsa030220.42390039
152Biosynthesis of amino acids_Homo sapiens_hsa012300.41818985
153Proteoglycans in cancer_Homo sapiens_hsa052050.41669829
154Oxytocin signaling pathway_Homo sapiens_hsa049210.40307397
155Sphingolipid metabolism_Homo sapiens_hsa006000.39041377
156Glutamatergic synapse_Homo sapiens_hsa047240.38013952
157Long-term potentiation_Homo sapiens_hsa047200.37962160
158Long-term depression_Homo sapiens_hsa047300.37836812
159Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37760051
160cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37525521
161PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37499300
162Insulin resistance_Homo sapiens_hsa049310.36546438
163Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36539516
164Circadian entrainment_Homo sapiens_hsa047130.35866772
165Prolactin signaling pathway_Homo sapiens_hsa049170.34980894
166Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31914174

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