CHST4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an N-acetylglucosamine 6-O sulfotransferase. The encoded enzyme transfers sulfate from 3'phosphoadenosine 5'phospho-sulfate to the 6-hydroxyl group of N-acetylglucosamine on glycoproteins. This protein is localized to the Golgi and is involved in the modification of glycan structures on ligands of the lymphocyte homing receptor L-selectin. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)7.75683110
2maintenance of gastrointestinal epithelium (GO:0030277)7.51778675
3intestinal epithelial cell development (GO:0060576)7.08567930
4negative regulation of catenin import into nucleus (GO:0035414)6.53415215
5bundle of His cell to Purkinje myocyte communication (GO:0086069)5.97542741
6UDP-N-acetylglucosamine metabolic process (GO:0006047)5.96611978
7regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)5.78012898
8epithelial structure maintenance (GO:0010669)5.63001146
9bile acid and bile salt transport (GO:0015721)5.62263935
10digestive tract morphogenesis (GO:0048546)5.51028586
11negative regulation of JUN kinase activity (GO:0043508)5.50655286
12intestinal cholesterol absorption (GO:0030299)5.45542469
13flavonoid metabolic process (GO:0009812)5.39795035
14O-glycan processing (GO:0016266)5.32547000
15regulation of posttranscriptional gene silencing (GO:0060147)5.20489277
16regulation of gene silencing by miRNA (GO:0060964)5.20489277
17regulation of gene silencing by RNA (GO:0060966)5.20489277
18lung secretory cell differentiation (GO:0061140)5.10299182
19planar cell polarity pathway involved in neural tube closure (GO:0090179)5.03620745
20digestive system process (GO:0022600)4.99362891
21actin filament depolymerization (GO:0030042)4.94687844
22angiotensin maturation (GO:0002003)4.73905802
23convergent extension (GO:0060026)4.70597404
24low-density lipoprotein particle remodeling (GO:0034374)4.66803578
25lung-associated mesenchyme development (GO:0060484)4.58590956
26regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.58515212
27establishment of integrated proviral latency (GO:0075713)4.51355792
28vitamin A metabolic process (GO:0006776)4.44116093
29purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.43306817
303-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.43306817
31regulation of non-canonical Wnt signaling pathway (GO:2000050)4.40998230
32otic vesicle formation (GO:0030916)4.36972516
33phosphatidylserine acyl-chain remodeling (GO:0036150)4.33497483
34hyperosmotic salinity response (GO:0042538)4.27351151
35calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.18386621
36virion attachment to host cell (GO:0019062)4.14347674
37adhesion of symbiont to host cell (GO:0044650)4.14347674
38hepatocyte apoptotic process (GO:0097284)4.11676564
39lung lobe morphogenesis (GO:0060463)4.09183155
40auditory receptor cell differentiation (GO:0042491)4.06219571
41regulation of bile acid biosynthetic process (GO:0070857)4.05127629
42phosphatidylinositol acyl-chain remodeling (GO:0036149)4.03673492
43glandular epithelial cell differentiation (GO:0002067)4.02096985
44regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.00226205
45post-anal tail morphogenesis (GO:0036342)3.86319429
46L-serine metabolic process (GO:0006563)3.85613808
47prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.80775414
48regulation of respiratory burst (GO:0060263)3.79736273
49regulation of catenin import into nucleus (GO:0035412)3.78806445
50positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.72834198
51pyrimidine-containing compound transmembrane transport (GO:0072531)3.71729717
52sulfate transmembrane transport (GO:1902358)3.70265782
53digestion (GO:0007586)3.63440015
54IMP biosynthetic process (GO:0006188)3.63144479
55negative regulation of protein kinase B signaling (GO:0051898)3.60972096
56protein complex localization (GO:0031503)3.59697039
57branching involved in labyrinthine layer morphogenesis (GO:0060670)3.58746746
58artery smooth muscle contraction (GO:0014824)3.55956570
59notochord development (GO:0030903)3.54120237
60mitotic metaphase plate congression (GO:0007080)3.53198752
61phosphatidylserine metabolic process (GO:0006658)3.50348237
62cellular response to hepatocyte growth factor stimulus (GO:0035729)3.45639589
63response to hepatocyte growth factor (GO:0035728)3.45639589
64lateral sprouting from an epithelium (GO:0060601)3.45424728
65protein localization to kinetochore (GO:0034501)3.45233866
66regulation of helicase activity (GO:0051095)3.44486174
67sulfur amino acid catabolic process (GO:0000098)3.42768765
68paraxial mesoderm development (GO:0048339)3.41524102
69phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.39998436
70ribosome assembly (GO:0042255)3.39574500
71plasma lipoprotein particle remodeling (GO:0034369)3.38369200
72protein-lipid complex remodeling (GO:0034368)3.38369200
73macromolecular complex remodeling (GO:0034367)3.38369200
74establishment of viral latency (GO:0019043)3.37543767
75phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.37194981
76mucosal immune response (GO:0002385)3.36117983
77regulation of cell fate specification (GO:0042659)3.35030530
78transcytosis (GO:0045056)3.34309509
79cellular glucuronidation (GO:0052695)3.33355878
80glutathione derivative biosynthetic process (GO:1901687)3.32542080
81glutathione derivative metabolic process (GO:1901685)3.32542080
82L-alpha-amino acid transmembrane transport (GO:1902475)3.30472666
83IMP metabolic process (GO:0046040)3.29236263
84regulation of hydrogen peroxide metabolic process (GO:0010310)3.28781356
85protein O-linked glycosylation (GO:0006493)3.27801715
86regulation of cell fate commitment (GO:0010453)3.27203413
87regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.24973215
88regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.24660937
89bicarbonate transport (GO:0015701)3.23065782
90positive regulation of lipoprotein lipase activity (GO:0051006)3.21888413
91positive regulation of triglyceride lipase activity (GO:0061365)3.21888413
92adhesion of symbiont to host (GO:0044406)3.21869492
93drug catabolic process (GO:0042737)3.21278679
94pre-miRNA processing (GO:0031054)3.21108583
95sperm capacitation (GO:0048240)3.19818002
96uronic acid metabolic process (GO:0006063)3.19091539
97glucuronate metabolic process (GO:0019585)3.19091539
98organ or tissue specific immune response (GO:0002251)3.17980105
99serine family amino acid biosynthetic process (GO:0009070)3.17236859
100heterochromatin organization (GO:0070828)3.15139006
101phenylpropanoid metabolic process (GO:0009698)3.14493024
102lactate metabolic process (GO:0006089)3.14422601
103ventricular cardiac muscle cell action potential (GO:0086005)3.13976037
104branching involved in salivary gland morphogenesis (GO:0060445)3.11345687
105hemidesmosome assembly (GO:0031581)3.09835026
106regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.08399012
107regulation of mitotic spindle checkpoint (GO:1903504)3.08399012
108regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.07229089
109positive regulation of epidermal cell differentiation (GO:0045606)3.03984180
110negative regulation of keratinocyte proliferation (GO:0010839)3.03349643
111tonic smooth muscle contraction (GO:0014820)3.02886704
112chromatin remodeling at centromere (GO:0031055)3.00825097
113negative regulation of transcription by competitive promoter binding (GO:0010944)2.98438336
114alditol phosphate metabolic process (GO:0052646)2.98321791
115plasma lipoprotein particle organization (GO:0071827)2.97637772
116protein-lipid complex subunit organization (GO:0071825)2.96745207
117DNA strand elongation involved in DNA replication (GO:0006271)2.96011043
118regulation of cholesterol homeostasis (GO:2000188)2.95565700
119regulation of triglyceride catabolic process (GO:0010896)2.94224567
120metaphase plate congression (GO:0051310)2.94205593
121erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.94194445
122L-phenylalanine metabolic process (GO:0006558)2.94194445
123diacylglycerol metabolic process (GO:0046339)2.92782312
124ethanol metabolic process (GO:0006067)2.91668421
125CENP-A containing nucleosome assembly (GO:0034080)2.90786214
126purine nucleobase biosynthetic process (GO:0009113)2.88184430
127positive regulation of SMAD protein import into nucleus (GO:0060391)2.87391542
128triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.86484214
129cysteine metabolic process (GO:0006534)2.85304866
130sulfate transport (GO:0008272)2.85293983
131nucleotide transmembrane transport (GO:1901679)2.84634468
132regulation of stem cell maintenance (GO:2000036)2.84309410
133desmosome organization (GO:0002934)2.82130420
134negative regulation of mitosis (GO:0045839)2.81879442
135cellular ketone body metabolic process (GO:0046950)2.81342635
136negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.80426310
137negative regulation of translation, ncRNA-mediated (GO:0040033)2.80426310
138regulation of translation, ncRNA-mediated (GO:0045974)2.80426310
139tight junction assembly (GO:0070830)2.80369835
140mesenchymal cell proliferation (GO:0010463)2.80205930
141phosphatidic acid biosynthetic process (GO:0006654)2.79976516
142phosphatidic acid metabolic process (GO:0046473)2.79976516
143DNA strand elongation (GO:0022616)2.79828787
144mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.79311879
145organ growth (GO:0035265)2.79018502
146galactose metabolic process (GO:0006012)2.77594309
147negative regulation of cell fate commitment (GO:0010454)2.77199631
148telomere maintenance via telomerase (GO:0007004)2.76107489
149bile acid metabolic process (GO:0008206)2.75806988
150galactose catabolic process (GO:0019388)2.75357614
151protein-lipid complex assembly (GO:0065005)2.75002996
152glycine metabolic process (GO:0006544)2.74477961
153negative regulation of protein tyrosine kinase activity (GO:0061099)2.74045513
154plasma lipoprotein particle assembly (GO:0034377)2.73902994
155hair cell differentiation (GO:0035315)2.73046895
156transepithelial transport (GO:0070633)2.71433512
157regulation of viral entry into host cell (GO:0046596)2.71157821
158nucleotide-sugar metabolic process (GO:0009225)2.70186525
159nucleobase biosynthetic process (GO:0046112)2.69146366
160omega-hydroxylase P450 pathway (GO:0097267)2.69071233
161serine family amino acid metabolic process (GO:0009069)2.68713901
162protein localization to chromosome, centromeric region (GO:0071459)2.67728133
163blastocyst development (GO:0001824)2.66342551
164drug metabolic process (GO:0017144)2.66214588
165regulation of actin nucleation (GO:0051125)2.66095017
166nuclear pore complex assembly (GO:0051292)2.65499586
167cholesterol homeostasis (GO:0042632)2.65295107
168nucleotide-sugar biosynthetic process (GO:0009226)2.65158565
169regulation of cholesterol esterification (GO:0010872)2.64341225
170phospholipid efflux (GO:0033700)2.63244734
171primary alcohol catabolic process (GO:0034310)2.63037627
172sterol homeostasis (GO:0055092)2.62732790
173regulation of gene silencing (GO:0060968)2.62503217
174nodal signaling pathway (GO:0038092)2.61144493
175lipoprotein metabolic process (GO:0042157)2.59750555
176ATP synthesis coupled proton transport (GO:0015986)2.59443416
177histone exchange (GO:0043486)2.59432520
178negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.59294607
179negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.59294607
180negative regulation of mitotic sister chromatid segregation (GO:0033048)2.59294607
181negative regulation of mitotic sister chromatid separation (GO:2000816)2.59294607
182negative regulation of sister chromatid segregation (GO:0033046)2.59294607
183negative regulation of gene silencing (GO:0060969)2.58797237
184cell fate commitment involved in formation of primary germ layer (GO:0060795)2.58338994
185negative regulation of nuclear division (GO:0051784)2.58096292
186Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.57473910
187negative regulation of chromosome segregation (GO:0051985)2.57250989
188erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.55312289
189L-phenylalanine catabolic process (GO:0006559)2.55312289
190negative regulation of telomerase activity (GO:0051974)2.55053636
191diterpenoid biosynthetic process (GO:0016102)2.54641360
192rRNA modification (GO:0000154)2.54079494
193negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.53504597
194energy homeostasis (GO:0097009)2.53204295

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.39435410
2E2F7_22180533_ChIP-Seq_HELA_Human6.12624372
3CDX2_20551321_ChIP-Seq_CACO-2_Human4.70362064
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.85494250
5* SOX2_27498859_Chip-Seq_STOMACH_Mouse3.52521646
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.51405105
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.47440100
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.36488988
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.14848393
10TRIM28_21343339_ChIP-Seq_HEK293_Human3.12243476
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.09267855
12CDX2_19796622_ChIP-Seq_MESCs_Mouse3.06928838
13GATA4_25053715_ChIP-Seq_YYC3_Human2.87552042
14* SOX2_20726797_ChIP-Seq_SW620_Human2.77928394
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.73107254
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.71237224
17ESR1_20079471_ChIP-ChIP_T-47D_Human2.61119046
18AR_21909140_ChIP-Seq_LNCAP_Human2.60914036
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.55858205
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.53115883
21PPARA_22158963_ChIP-Seq_LIVER_Mouse2.50213207
22GATA6_25053715_ChIP-Seq_YYC3_Human2.45108876
23TCF3_18692474_ChIP-Seq_MEFs_Mouse2.41268069
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.40439721
25E2F4_17652178_ChIP-ChIP_JURKAT_Human2.28566872
26SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.27886974
27FOXM1_23109430_ChIP-Seq_U2OS_Human2.27410168
28RXR_22158963_ChIP-Seq_LIVER_Mouse2.26192924
29HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.19123209
30ESR2_21235772_ChIP-Seq_MCF-7_Human2.13735416
31KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.12767025
32KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.12767025
33KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.12767025
34FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.11118122
35LXR_22158963_ChIP-Seq_LIVER_Mouse2.10709556
36NANOG_18555785_ChIP-Seq_MESCs_Mouse2.05485165
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.03442202
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.03186528
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97985287
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.97383974
41PPAR_26484153_Chip-Seq_NCI-H1993_Human1.96752983
42NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94336041
43SOX2_18555785_ChIP-Seq_MESCs_Mouse1.93135638
44MYC_18358816_ChIP-ChIP_MESCs_Mouse1.93121256
45GABP_17652178_ChIP-ChIP_JURKAT_Human1.92628323
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.90802201
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.87632766
48NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.84566069
49EST1_17652178_ChIP-ChIP_JURKAT_Human1.83815859
50ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.83687198
51DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.81996112
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81923248
53STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.79901939
54JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.74652751
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.70498055
56* NANOG_16153702_ChIP-ChIP_HESCs_Human1.70376163
57TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68486813
58ESR1_21235772_ChIP-Seq_MCF-7_Human1.66998066
59CREB1_15753290_ChIP-ChIP_HEK293T_Human1.65532676
60TCF3_18692474_ChIP-Seq_MESCs_Mouse1.62677992
61KLF5_25053715_ChIP-Seq_YYC3_Human1.62280122
62ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.61283460
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.59217978
64RUNX1_27514584_Chip-Seq_MCF-7_Human1.54705537
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54335676
66BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.54296003
67RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.54230114
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.50323223
69VDR_22108803_ChIP-Seq_LS180_Human1.48662807
70KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48636830
71NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.45444041
72SOX2_16153702_ChIP-ChIP_HESCs_Human1.44951177
73SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.43970749
74CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.43355328
75SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.42590263
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.41974179
77MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41689529
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.41433970
79SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.40834403
80RACK7_27058665_Chip-Seq_MCF-7_Human1.40771608
81E2F1_21310950_ChIP-Seq_MCF-7_Human1.40671037
82ETS1_20019798_ChIP-Seq_JURKAT_Human1.39549553
83SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.38782164
84TCF4_18268006_ChIP-ChIP_LS174T_Human1.38121404
85CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37683844
86KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34629072
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33042801
88MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.32973463
89EGR1_19374776_ChIP-ChIP_THP-1_Human1.32605327
90ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30980680
91EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.28780743
92ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.27729631
93BCAT_22108803_ChIP-Seq_LS180_Human1.27708141
94NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27574168
95NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.23092456
96DCP1A_22483619_ChIP-Seq_HELA_Human1.22663811
97NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.21421427
98STAT1_20625510_ChIP-Seq_HELA_Human1.21020652
99DROSHA_22980978_ChIP-Seq_HELA_Human1.20097622
100POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18451487
101STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18279518
102SOX2_18692474_ChIP-Seq_MEFs_Mouse1.18105231
103SALL1_21062744_ChIP-ChIP_HESCs_Human1.17914240
104CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15044978
105ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14202002
106ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12055857
107GATA2_19941826_ChIP-Seq_K562_Human1.11625698
108SOX17_20123909_ChIP-Seq_XEN_Mouse1.11557777
109GATA3_24758297_ChIP-Seq_MCF-7_Human1.11207887
110SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10680201
111AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.10390949
112CLOCK_20551151_ChIP-Seq_293T_Human1.09969959
113STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09757761
114SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.09337942
115FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.09125437
116NANOG_18692474_ChIP-Seq_MEFs_Mouse1.08870290
117PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08515434
118ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07433464
119ATF3_27146783_Chip-Seq_COLON_Human1.07276701
120PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.06762425
121THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06648946
122ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.06596169
123NANOG_21062744_ChIP-ChIP_HESCs_Human1.05992579
124KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05988044
125P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05782072
126GATA2_21666600_ChIP-Seq_HMVEC_Human1.05614797
127OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03473166
128YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03332902
129NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.02798319
130ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.02562921
131EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02358850
132PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02199375
133TTF2_22483619_ChIP-Seq_HELA_Human1.02045495
134HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.01810091
135ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01249780
136HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00963352
137ELK1_19687146_ChIP-ChIP_HELA_Human1.00711484
138PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00690240
139SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99252962
140SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99252962
141XRN2_22483619_ChIP-Seq_HELA_Human0.98534945
142FOXA1_25552417_ChIP-Seq_VCAP_Human0.97892030
143FOXP3_21729870_ChIP-Seq_TREG_Human0.96978797
144FOXA2_19822575_ChIP-Seq_HepG2_Human0.96816380
145GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96482666
146CTCF_27219007_Chip-Seq_Bcells_Human0.96451870
147FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95748577
148FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.94429186
149GATA1_19941826_ChIP-Seq_K562_Human0.94079194
150BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.91782952
151RAD21_21589869_ChIP-Seq_MESCs_Mouse0.90640888
152FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89457562
153TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89271457
154EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89105831
155HNF4A_19822575_ChIP-Seq_HepG2_Human0.88989869
156IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.88367075
157LXR_22292898_ChIP-Seq_THP-1_Human0.88248102
158KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88222954
159CDX2_22108803_ChIP-Seq_LS180_Human0.88088839
160CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87938553
161JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87344141
162GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84945635
163CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.84018287
164SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.82290918
165ZNF263_19887448_ChIP-Seq_K562_Human0.82255960
166SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.80752876
167UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.80232214
168NANOG_20526341_ChIP-Seq_ESCs_Human0.79543443
169RARG_19884340_ChIP-ChIP_MEFs_Mouse0.78907942
170TP63_22573176_ChIP-Seq_HFKS_Human0.78153192
171NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.77909041
172AHR_22903824_ChIP-Seq_MCF-7_Human0.77355185
173EP300_21415370_ChIP-Seq_HL-1_Mouse0.76624568
174CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.76517583
175CJUN_26792858_Chip-Seq_BT549_Human0.75984208
176SALL4_18804426_ChIP-ChIP_XEN_Mouse0.75625394
177RXR_22108803_ChIP-Seq_LS180_Human0.75534424
178* ELF5_23300383_ChIP-Seq_T47D_Human0.74240892
179CTCF_20526341_ChIP-Seq_ESCs_Human0.72526477
180Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.72204698

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis5.88667404
2MP0005360_urolithiasis5.72887410
3MP0001666_abnormal_nutrient_absorption4.50898366
4MP0010234_abnormal_vibrissa_follicle4.45405129
5MP0003941_abnormal_skin_development4.29543955
6MP0003866_abnormal_defecation3.62867317
7MP0000462_abnormal_digestive_system3.55396617
8MP0010386_abnormal_urinary_bladder3.44039059
9MP0010030_abnormal_orbit_morphology3.23941074
10MP0001663_abnormal_digestive_system3.22278149
11MP0010155_abnormal_intestine_physiology3.20601057
12MP0001873_stomach_inflammation3.20289776
13MP0005085_abnormal_gallbladder_physiolo3.20241509
14MP0004264_abnormal_extraembryonic_tissu3.19012460
15MP0002139_abnormal_hepatobiliary_system3.08639749
16MP0003693_abnormal_embryo_hatching3.03508322
17MP0004957_abnormal_blastocyst_morpholog3.02238138
18MP0005381_digestive/alimentary_phenotyp2.99158806
19MP0002254_reproductive_system_inflammat2.97095459
20MP0008875_abnormal_xenobiotic_pharmacok2.95574988
21MP0001664_abnormal_digestion2.72552560
22MP0003868_abnormal_feces_composition2.71974958
23MP0008004_abnormal_stomach_pH2.62306658
24MP0000490_abnormal_crypts_of2.62203891
25MP0003252_abnormal_bile_duct2.56100541
26MP0003718_maternal_effect2.40997274
27MP0000477_abnormal_intestine_morphology2.39452838
28MP0000537_abnormal_urethra_morphology2.21406226
29MP0002928_abnormal_bile_duct2.17752529
30MP0005365_abnormal_bile_salt2.11076141
31MP0001346_abnormal_lacrimal_gland2.10577364
32MP0003705_abnormal_hypodermis_morpholog2.09188409
33MP0003111_abnormal_nucleus_morphology2.05394690
34MP0009672_abnormal_birth_weight2.02111020
35MP0005451_abnormal_body_composition1.98567598
36MP0010352_gastrointestinal_tract_polyps1.95552914
37MP0002277_abnormal_respiratory_mucosa1.92105566
38MP0009840_abnormal_foam_cell1.90583831
39MP0005083_abnormal_biliary_tract1.87614665
40MP0008058_abnormal_DNA_repair1.83020963
41MP0010094_abnormal_chromosome_stability1.81976674
42MP0005220_abnormal_exocrine_pancreas1.74273667
43MP0008877_abnormal_DNA_methylation1.72089478
44MP0005666_abnormal_adipose_tissue1.70094237
45MP0010329_abnormal_lipoprotein_level1.69838356
46MP0002796_impaired_skin_barrier1.69179529
47MP0003077_abnormal_cell_cycle1.67800867
48MP0003806_abnormal_nucleotide_metabolis1.67064612
49MP0003890_abnormal_embryonic-extraembry1.66319931
50MP0000465_gastrointestinal_hemorrhage1.58998278
51MP0002822_catalepsy1.57396430
52MP0004019_abnormal_vitamin_homeostasis1.56344140
53MP0003300_gastrointestinal_ulcer1.54469514
54MP0000579_abnormal_nail_morphology1.54007998
55MP0008932_abnormal_embryonic_tissue1.53525283
56MP0003878_abnormal_ear_physiology1.52017491
57MP0005377_hearing/vestibular/ear_phenot1.52017491
58MP0002089_abnormal_postnatal_growth/wei1.49985197
59MP0003191_abnormal_cellular_cholesterol1.49837171
60MP0001730_embryonic_growth_arrest1.47930079
61MP0003183_abnormal_peptide_metabolism1.46916603
62MP0005167_abnormal_blood-brain_barrier1.43891240
63MP0010678_abnormal_skin_adnexa1.43113794
64MP0003943_abnormal_hepatobiliary_system1.43074669
65MP0002163_abnormal_gland_morphology1.42105434
66MP0008007_abnormal_cellular_replicative1.39518384
67MP0001188_hyperpigmentation1.38750573
68MP0006054_spinal_hemorrhage1.37294523
69MP0004043_abnormal_pH_regulation1.34642476
70MP0002233_abnormal_nose_morphology1.32850544
71MP0000470_abnormal_stomach_morphology1.30435209
72MP0005165_increased_susceptibility_to1.28961408
73MP0008057_abnormal_DNA_replication1.27786213
74MP0001765_abnormal_ion_homeostasis1.25195714
75MP0004185_abnormal_adipocyte_glucose1.24820066
76MP0000467_abnormal_esophagus_morphology1.23740629
77MP0001849_ear_inflammation1.23167347
78MP0000538_abnormal_urinary_bladder1.21854865
79MP0004147_increased_porphyrin_level1.21605850
80MP0005395_other_phenotype1.19177878
81MP0005166_decreased_susceptibility_to1.17604427
82MP0009379_abnormal_foot_pigmentation1.16730005
83MP0009643_abnormal_urine_homeostasis1.14688715
84MP0003950_abnormal_plasma_membrane1.12281323
85MP0009780_abnormal_chondrocyte_physiolo1.10453214
86MP0000350_abnormal_cell_proliferation1.10001656
87MP0005448_abnormal_energy_balance1.08948698
88MP0001299_abnormal_eye_distance/1.08916628
89MP0003283_abnormal_digestive_organ1.08447186
90MP0009703_decreased_birth_body1.08076284
91MP0005380_embryogenesis_phenotype1.07065048
92MP0001672_abnormal_embryogenesis/_devel1.07065048
93MP0004272_abnormal_basement_membrane1.06734669
94MP0002118_abnormal_lipid_homeostasis1.06630614
95MP0002084_abnormal_developmental_patter1.03803526
96MP0003566_abnormal_cell_adhesion1.01603658
97MP0003937_abnormal_limbs/digits/tail_de0.99850868
98MP0005375_adipose_tissue_phenotype0.98872981
99MP0002085_abnormal_embryonic_tissue0.98340925
100MP0000762_abnormal_tongue_morphology0.97765510
101MP0005636_abnormal_mineral_homeostasis0.93288022
102MP0004947_skin_inflammation0.92566949
103MP0003984_embryonic_growth_retardation0.86424001
104MP0002088_abnormal_embryonic_growth/wei0.85046566
105MP0003453_abnormal_keratinocyte_physiol0.84616104
106MP0005501_abnormal_skin_physiology0.84544727
107MP0009697_abnormal_copulation0.84116547
108MP0001697_abnormal_embryo_size0.83066047
109MP0000647_abnormal_sebaceous_gland0.83017641
110MP0008872_abnormal_physiological_respon0.82294642
111MP0002697_abnormal_eye_size0.81588527
112MP0002080_prenatal_lethality0.81098335
113MP0003119_abnormal_digestive_system0.78909606
114MP0004484_altered_response_of0.78309792
115MP0000609_abnormal_liver_physiology0.75111819
116MP0005332_abnormal_amino_acid0.75063680
117MP0002098_abnormal_vibrissa_morphology0.73331839
118MP0002111_abnormal_tail_morphology0.72781186
119MP0006035_abnormal_mitochondrial_morpho0.72570629
120MP0002086_abnormal_extraembryonic_tissu0.72114318
121MP0001216_abnormal_epidermal_layer0.70095667
122MP0002138_abnormal_hepatobiliary_system0.69829552
123MP0006036_abnormal_mitochondrial_physio0.69672034
124MP0005084_abnormal_gallbladder_morpholo0.68904357
125MP0001845_abnormal_inflammatory_respons0.67317297
126MP0001944_abnormal_pancreas_morphology0.66393573
127MP0004133_heterotaxia0.66021636
128MP0005319_abnormal_enzyme/_coenzyme0.65113852
129MP0001293_anophthalmia0.63288686
130MP0004197_abnormal_fetal_growth/weight/0.63094885
131MP0004858_abnormal_nervous_system0.62431668
132MP0002136_abnormal_kidney_physiology0.62220410
133MP0001177_atelectasis0.62204044
134MP0000383_abnormal_hair_follicle0.61850734
135MP0008789_abnormal_olfactory_epithelium0.61724355
136MP0003567_abnormal_fetal_cardiomyocyte0.61697730
137MP0000013_abnormal_adipose_tissue0.61291139
138MP0005379_endocrine/exocrine_gland_phen0.59977951
139MP0001485_abnormal_pinna_reflex0.59871130
140MP0005310_abnormal_salivary_gland0.59463194
141MP0004782_abnormal_surfactant_physiolog0.59440226
142MP0009764_decreased_sensitivity_to0.58218003
143MP0003938_abnormal_ear_development0.58135767
144MP0002060_abnormal_skin_morphology0.57100778
145MP0001286_abnormal_eye_development0.56689770
146MP0000613_abnormal_salivary_gland0.55989954
147MP0002876_abnormal_thyroid_physiology0.55892739
148MP0008873_increased_physiological_sensi0.55800430
149MP0002282_abnormal_trachea_morphology0.55598438
150MP0001756_abnormal_urination0.55325649
151MP0005367_renal/urinary_system_phenotyp0.55216441
152MP0000516_abnormal_urinary_system0.55216441
153MP0000678_abnormal_parathyroid_gland0.54162051
154MP0005394_taste/olfaction_phenotype0.53368638
155MP0005499_abnormal_olfactory_system0.53368638
156MP0003075_altered_response_to0.51608413
157MP0003724_increased_susceptibility_to0.50386879
158MP0009053_abnormal_anal_canal0.49468688
159MP0005334_abnormal_fat_pad0.49237162
160MP0010771_integument_phenotype0.48894924
161MP0009785_altered_susceptibility_to0.47715199
162MP0002132_abnormal_respiratory_system0.47032513
163MP0005248_abnormal_Harderian_gland0.46626636
164MP0000230_abnormal_systemic_arterial0.46488882
165MP0003879_abnormal_hair_cell0.44958306
166MP0004742_abnormal_vestibular_system0.44007633

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)7.91234830
2Right ventricular cardiomyopathy (HP:0011663)6.86823575
3Abnormality of the labia minora (HP:0012880)6.05071525
4Stenosis of the external auditory canal (HP:0000402)4.71949034
5Hyperactive renin-angiotensin system (HP:0000841)4.68488547
6Malnutrition (HP:0004395)4.59097801
7Aplasia involving bones of the upper limbs (HP:0009823)4.41972470
8Aplasia of the phalanges of the hand (HP:0009802)4.41972470
9Aplasia involving bones of the extremities (HP:0009825)4.41972470
10Abdominal distention (HP:0003270)4.41860907
11Gout (HP:0001997)4.41638613
12Partial duplication of thumb phalanx (HP:0009944)4.32134917
13Metabolic alkalosis (HP:0200114)4.05107406
14Micronodular cirrhosis (HP:0001413)3.71287617
15Abnormality of the middle phalanges of the toes (HP:0010183)3.69891687
16Abnormality of glutamine family amino acid metabolism (HP:0010902)3.69513662
17Partial duplication of the phalanx of hand (HP:0009999)3.58009924
18Conjugated hyperbilirubinemia (HP:0002908)3.53569902
19Syncope (HP:0001279)3.41728629
20Bronchomalacia (HP:0002780)3.35334626
21Abnormality of renin-angiotensin system (HP:0000847)3.32909599
22Chronic diarrhea (HP:0002028)3.31763454
23Abnormality of chloride homeostasis (HP:0011422)3.29123139
24Choanal stenosis (HP:0000452)3.27304203
25Bundle branch block (HP:0011710)3.26781762
26Hypoplastic labia majora (HP:0000059)3.25465246
27Intrahepatic cholestasis (HP:0001406)3.19752682
28Ventricular fibrillation (HP:0001663)3.18338343
29Abnormality of the salivary glands (HP:0010286)3.16613609
30Decreased circulating renin level (HP:0003351)3.15848154
31Palpitations (HP:0001962)3.13223022
32Woolly hair (HP:0002224)3.12859997
33Fat malabsorption (HP:0002630)3.08304502
34Hypobetalipoproteinemia (HP:0003563)3.07703917
35Hypoplastic female external genitalia (HP:0012815)3.02062136
36Labial hypoplasia (HP:0000066)2.96908935
37Coronal craniosynostosis (HP:0004440)2.96622395
38Abnormality of the vitamin B12 metabolism (HP:0004341)2.96057919
39Thickened helices (HP:0000391)2.95636107
40Acanthocytosis (HP:0001927)2.94424792
41Gastrointestinal dysmotility (HP:0002579)2.92793439
42Abnormality of the dental root (HP:0006486)2.91180592
43Taurodontia (HP:0000679)2.91180592
44Abnormality of permanent molar morphology (HP:0011071)2.91180592
45Rectal prolapse (HP:0002035)2.91069711
46Abnormality of the labia majora (HP:0012881)2.89391852
47Stomach cancer (HP:0012126)2.87559539
48Abnormal pancreas size (HP:0012094)2.86168540
49Humeroradial synostosis (HP:0003041)2.84945526
50Synostosis involving the elbow (HP:0003938)2.84945526
51Abnormality of aromatic amino acid family metabolism (HP:0004338)2.83858663
52Glycosuria (HP:0003076)2.82230699
53Abnormality of urine glucose concentration (HP:0011016)2.82230699
54Potter facies (HP:0002009)2.81696459
55Facial shape deformation (HP:0011334)2.81696459
56Alacrima (HP:0000522)2.80622011
57Broad metatarsal (HP:0001783)2.79201909
58Fused cervical vertebrae (HP:0002949)2.78467193
59Hyperparathyroidism (HP:0000843)2.77838218
60Abnormality of the phalanges of the 2nd finger (HP:0009541)2.76745606
61Congenital sensorineural hearing impairment (HP:0008527)2.76634380
62Mildly elevated creatine phosphokinase (HP:0008180)2.74795400
63Abnormality of vitamin B metabolism (HP:0004340)2.73575757
64Ventricular tachycardia (HP:0004756)2.71253048
65Turricephaly (HP:0000262)2.71016805
66Clitoromegaly (HP:0000057)2.68267711
67Dehydration (HP:0001944)2.67556559
68Bifid scrotum (HP:0000048)2.67043601
69Esophageal varix (HP:0002040)2.66392121
70Abnormality of monocarboxylic acid metabolism (HP:0010996)2.65914337
71Abnormality of the lacrimal duct (HP:0011481)2.65217237
72Absent radius (HP:0003974)2.64758739
73Flat acetabular roof (HP:0003180)2.64087791
74Cupped ribs (HP:0000887)2.63385036
75Abnormality of molar morphology (HP:0011070)2.63092143
76Abnormality of molar (HP:0011077)2.63092143
77Autoimmune thrombocytopenia (HP:0001973)2.62639205
78Aqueductal stenosis (HP:0002410)2.62403080
79Enlarged kidneys (HP:0000105)2.62032052
80Abnormality of the dental pulp (HP:0006479)2.59195736
81Duplication of thumb phalanx (HP:0009942)2.58080599
82Facial cleft (HP:0002006)2.54374197
83Abnormality of the labia (HP:0000058)2.54146996
84Chronic bronchitis (HP:0004469)2.53943967
85Abnormality of vitamin metabolism (HP:0100508)2.50138147
86Absent forearm bone (HP:0003953)2.47623530
87Aplasia involving forearm bones (HP:0009822)2.47623530
88Hypoplasia of the uterus (HP:0000013)2.47386887
89Prolonged QT interval (HP:0001657)2.45198886
90Xanthomatosis (HP:0000991)2.45013863
91Abnormality of proline metabolism (HP:0010907)2.44304509
92Hydroxyprolinuria (HP:0003080)2.44304509
93Nasolacrimal duct obstruction (HP:0000579)2.44211716
94Short hallux (HP:0010109)2.42994581
95Abnormality of the 1st metacarpal (HP:0010009)2.41563712
96Hyperglycinemia (HP:0002154)2.40665875
97Chronic otitis media (HP:0000389)2.40319651
98Onycholysis (HP:0001806)2.39983592
99Abnormality of glycine metabolism (HP:0010895)2.36844130
100Abnormality of serine family amino acid metabolism (HP:0010894)2.36844130
101Milia (HP:0001056)2.36641200
102Atrophic scars (HP:0001075)2.35493610
103Pustule (HP:0200039)2.32622652
104Broad distal phalanx of finger (HP:0009836)2.31919024
105Decreased lacrimation (HP:0000633)2.31884631
106Abnormal biliary tract morphology (HP:0012440)2.28373120
107Conical tooth (HP:0000698)2.26051074
108Mesangial abnormality (HP:0001966)2.24970357
109Abnormality of the gastric mucosa (HP:0004295)2.24422885
110Split foot (HP:0001839)2.24197380
111Hyperaldosteronism (HP:0000859)2.23895427
112Hypoglycemic coma (HP:0001325)2.22850349
113Male infertility (HP:0003251)2.22495901
114Abnormality of small intestinal villus morphology (HP:0011472)2.22269331
115Villous atrophy (HP:0011473)2.22269331
116Aplasia/Hypoplasia of the hallux (HP:0008362)2.20045642
117Hypolipoproteinemia (HP:0010981)2.19448105
118Hyperuricemia (HP:0002149)2.18344481
119Increased purine levels (HP:0004368)2.18344481
120Alkalosis (HP:0001948)2.17205023
121Abnormal tarsal ossification (HP:0008369)2.16972763
122Fragile nails (HP:0001808)2.15433855
123Proximal tubulopathy (HP:0000114)2.15105380
124Abnormality of the nasolacrimal system (HP:0000614)2.15032201
125Abnormal foot bone ossification (HP:0010675)2.14875234
126Absent septum pellucidum (HP:0001331)2.13961079
127Ventricular arrhythmia (HP:0004308)2.13694733
128Reduced antithrombin III activity (HP:0001976)2.13431172
129Widely patent fontanelles and sutures (HP:0004492)2.12852678
130Carpal bone hypoplasia (HP:0001498)2.12083869
131Cupped ear (HP:0000378)2.11954602
132Cone-rod dystrophy (HP:0000548)2.11799267
133Increased muscle lipid content (HP:0009058)2.11273285
134Heart block (HP:0012722)2.09577184
135Overriding aorta (HP:0002623)2.09183639
136Recurrent corneal erosions (HP:0000495)2.06891123
137Abnormal atrioventricular conduction (HP:0005150)2.05422190
138Nausea (HP:0002018)2.04576615
139Abnormality of the clitoris (HP:0000056)2.03168665
140Dicarboxylic aciduria (HP:0003215)2.03084646
141Abnormality of dicarboxylic acid metabolism (HP:0010995)2.03084646
142Gastrointestinal atresia (HP:0002589)2.02814089
143Birth length less than 3rd percentile (HP:0003561)2.02546684
144Esophageal atresia (HP:0002032)2.02003784
145Hyperglycinuria (HP:0003108)2.01980681
146Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.01894260
147Breast carcinoma (HP:0003002)2.01202573
148Spastic diplegia (HP:0001264)2.01190712
149Abnormality of serum amino acid levels (HP:0003112)2.00653837
150Protuberant abdomen (HP:0001538)1.98452073
151Shallow orbits (HP:0000586)1.96349378
152Abnormality of purine metabolism (HP:0004352)1.95655784
153Abnormality of the septum pellucidum (HP:0007375)1.93719372
154Hypoglycemic seizures (HP:0002173)1.93714846
155Bone cyst (HP:0012062)1.93427130
156Autoimmune hemolytic anemia (HP:0001890)1.92976619
157Abnormal lung lobation (HP:0002101)1.92961859
158Goiter (HP:0000853)1.92591061
159Megalencephaly (HP:0001355)1.92438593
160Curly hair (HP:0002212)1.92090057
161Biliary tract neoplasm (HP:0100574)1.91525820
162Multiple enchondromatosis (HP:0005701)1.90819102
163Hyperphosphaturia (HP:0003109)1.90633669
164Increased intramyocellular lipid droplets (HP:0012240)1.90453344
165Acanthosis nigricans (HP:0000956)1.90122049
166Late onset (HP:0003584)1.89765538
167Abnormality of incisor morphology (HP:0011063)1.89755676
168Abnormality of aspartate family amino acid metabolism (HP:0010899)1.89486981
169Abnormal cartilage morphology (HP:0002763)1.89470922
170Conjunctival hamartoma (HP:0100780)1.88829773
171Colon cancer (HP:0003003)1.88460363
172Popliteal pterygium (HP:0009756)1.87945993
173Myopathic facies (HP:0002058)1.87945942
174Plantar hyperkeratosis (HP:0007556)1.87673736
175Pili torti (HP:0003777)1.87361910
176Hypokalemia (HP:0002900)1.87337584
177Preaxial foot polydactyly (HP:0001841)1.85539148
178Abnormality of glycolysis (HP:0004366)1.85271551
179Increased serum pyruvate (HP:0003542)1.85271551
180Median cleft lip (HP:0000161)1.84928577
181Symphalangism affecting the phalanges of the hand (HP:0009773)1.84627201
182Vascular calcification (HP:0004934)1.84336782
183Abnormality of sulfur amino acid metabolism (HP:0004339)1.83945321
184Neonatal death (HP:0003811)1.83111598
185Abnormality of fatty-acid metabolism (HP:0004359)1.82739473
186Pigmentary retinal degeneration (HP:0001146)1.80594870
187Aplasia/hypoplasia of the uterus (HP:0008684)1.80497725
188Bell-shaped thorax (HP:0001591)1.80003018
189Fragile skin (HP:0001030)1.79840566
190Generalized aminoaciduria (HP:0002909)1.79018081
191Hyperammonemia (HP:0001987)1.79008870
192Absent eyebrow (HP:0002223)1.77349613
193Mixed hearing impairment (HP:0000410)1.76863588
194Abnormality of the distal phalanx of the thumb (HP:0009617)1.76511431
195Hypoplasia of dental enamel (HP:0006297)1.75904872

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.67896175
2MST45.06748543
3LMTK24.88018767
4FGFR24.53339573
5NME14.22102171
6MST1R3.90011835
7TSSK62.87659737
8MAP2K22.86945291
9BUB12.80011774
10PRKG22.66200845
11VRK22.46415965
12MAPK152.45646206
13EPHB22.39299751
14ZAK2.19029110
15ERN12.12665908
16MYLK2.07815884
17STK38L2.06593263
18MAP3K22.04924827
19PIK3CA2.03482203
20PLK31.99233551
21RIPK11.98063134
22PTK61.91132649
23BRSK21.81421244
24EPHA21.79578891
25TESK11.74202139
26CDC71.73391557
27TAF11.71025097
28KSR21.69849669
29TAOK11.69094762
30VRK11.62922232
31MKNK21.61710607
32TNIK1.61029719
33MET1.60249105
34FGFR11.56415453
35SMG11.55874793
36RPS6KB21.50435753
37STK391.50431358
38SRPK11.46468585
39BLK1.44261719
40NUAK11.40864618
41LATS21.38056609
42MKNK11.34596345
43GRK61.30774824
44ERBB41.29625970
45STK241.26886156
46NEK11.26310082
47PLK11.24280872
48MAP2K11.22066617
49MAP3K71.14417026
50CAMK2D1.12730834
51NEK21.10276935
52FER1.09928215
53WEE11.09551377
54LATS11.08961465
55TRIM280.97121896
56MAP2K60.96928645
57CDK190.96327292
58ALK0.93812038
59LRRK20.93426135
60NME20.92234484
61STK100.91956159
62TTN0.91814758
63LIMK10.91554010
64PRKAA20.89204703
65EPHB10.88275199
66CAMK2B0.86418378
67STK30.86305973
68MAP3K10.86231638
69BRSK10.85833222
70MAP3K80.84968843
71PTK20.82304794
72DDR20.80950067
73DYRK30.80662646
74MAP3K90.78730867
75CAMK2G0.78646229
76PAK40.78146470
77DAPK10.75898555
78ARAF0.75627171
79WNK40.75122538
80NLK0.72899431
81PASK0.72880275
82PBK0.72811259
83STK160.72679264
84MAP3K100.72611193
85PAK30.72003466
86ERBB20.71206765
87TESK20.69719712
88CSK0.69079578
89FGFR40.68929342
90AURKB0.68891453
91PIK3CG0.67867953
92TRIB30.65745809
93PRKCI0.65682199
94EIF2AK30.63574258
95DYRK20.62514514
96AKT30.59882847
97OXSR10.59830532
98ATM0.57693511
99CSNK1G10.57393640
100PLK40.56823333
101MAP3K110.56293313
102MAPK110.55591626
103TEC0.52794133
104CHEK20.52506066
105RIPK40.52044381
106PKN20.51805208
107GRK10.50647891
108ATR0.49778822
109INSRR0.49370928
110CDK30.48869761
111PDK30.48351117
112PDK40.48351117
113STK40.47778341
114PRKAA10.45417450
115DAPK30.45347867
116EEF2K0.45218156
117MAP3K30.44289742
118TTK0.43496730
119TAOK30.43442098
120CHEK10.42531990
121CSNK1E0.42447836
122MATK0.41841294
123MAP3K120.41599746
124AURKA0.40670394
125CDK70.40163717
126PAK10.40034851
127FYN0.40017681
128CDK90.39072139
129MAP3K130.38755266
130TBK10.38493932
131PDPK10.38197847
132SRC0.37727501
133CSNK2A10.37314876
134PRKCA0.36848593
135CDK80.35405608
136PRKCQ0.34411121
137PIM20.34310564
138MELK0.34148030
139GSK3A0.33318496
140EGFR0.32305698
141ITK0.31597829
142WNK30.31187992
143CSNK1A10.30904328
144PDK20.30349218
145DMPK0.30101307
146BMX0.29063760
147BMPR1B0.28931176
148PRKDC0.28794718
149CSNK2A20.28249061
150RPS6KA40.28014000
151BCR0.27826312
152DYRK1B0.26529748
153ROCK10.25677652
154MAPKAPK20.25242191
155PRKACG0.24973603
156CSNK1G30.24882635
157CDK10.24153699
158CLK10.23895903
159PRKCE0.23440632
160FGR0.23386536
161PAK20.22871642
162PINK10.22543331
163TIE10.22197801
164CAMK2A0.22008201
165ROCK20.19782941
166PRKD10.18118205

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049754.59892735
2Sulfur metabolism_Homo sapiens_hsa009204.54452088
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.48305085
4Mineral absorption_Homo sapiens_hsa049783.30540678
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.85580863
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.74750683
7Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.66847521
8Proteasome_Homo sapiens_hsa030502.54877312
9DNA replication_Homo sapiens_hsa030302.45090923
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.44848850
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.40244136
12Mismatch repair_Homo sapiens_hsa034302.29948905
13Linoleic acid metabolism_Homo sapiens_hsa005912.28691029
14Cysteine and methionine metabolism_Homo sapiens_hsa002702.25968631
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.19493546
16Renin-angiotensin system_Homo sapiens_hsa046142.14014862
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.13526092
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.09421684
19Non-homologous end-joining_Homo sapiens_hsa034502.06132734
20Bile secretion_Homo sapiens_hsa049761.98452524
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.93124642
22One carbon pool by folate_Homo sapiens_hsa006701.88018823
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.83291128
24Histidine metabolism_Homo sapiens_hsa003401.74934344
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.74151839
26PPAR signaling pathway_Homo sapiens_hsa033201.72543153
27Glutathione metabolism_Homo sapiens_hsa004801.67587785
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.66988142
29Vitamin B6 metabolism_Homo sapiens_hsa007501.65278373
30Starch and sucrose metabolism_Homo sapiens_hsa005001.64675460
31Vitamin digestion and absorption_Homo sapiens_hsa049771.63504916
32Fructose and mannose metabolism_Homo sapiens_hsa000511.61493767
33Caffeine metabolism_Homo sapiens_hsa002321.59783346
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.58904071
35Galactose metabolism_Homo sapiens_hsa000521.57540368
36Ether lipid metabolism_Homo sapiens_hsa005651.54247346
37RNA transport_Homo sapiens_hsa030131.50397936
38Fatty acid degradation_Homo sapiens_hsa000711.49538392
39RNA polymerase_Homo sapiens_hsa030201.49282625
40Base excision repair_Homo sapiens_hsa034101.47910634
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.47907231
42Biosynthesis of amino acids_Homo sapiens_hsa012301.47805546
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.47477107
44Butanoate metabolism_Homo sapiens_hsa006501.39219132
45Cell cycle_Homo sapiens_hsa041101.36192998
46Chemical carcinogenesis_Homo sapiens_hsa052041.35572265
47Arachidonic acid metabolism_Homo sapiens_hsa005901.33429586
48Pancreatic secretion_Homo sapiens_hsa049721.33063419
49Protein digestion and absorption_Homo sapiens_hsa049741.28365640
50Homologous recombination_Homo sapiens_hsa034401.28101618
51Glycerolipid metabolism_Homo sapiens_hsa005611.25016431
52Spliceosome_Homo sapiens_hsa030401.18038199
53Tryptophan metabolism_Homo sapiens_hsa003801.16641381
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13775938
55Folate biosynthesis_Homo sapiens_hsa007901.13397458
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.13095036
57Tight junction_Homo sapiens_hsa045301.09240489
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08036568
59Carbohydrate digestion and absorption_Homo sapiens_hsa049731.05390034
60RNA degradation_Homo sapiens_hsa030181.04994144
61Pentose phosphate pathway_Homo sapiens_hsa000301.03849617
62Basal transcription factors_Homo sapiens_hsa030221.00138310
63Pyruvate metabolism_Homo sapiens_hsa006201.00030544
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98738815
65Oxidative phosphorylation_Homo sapiens_hsa001900.96813758
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.95689888
67Pyrimidine metabolism_Homo sapiens_hsa002400.94422151
68Ribosome_Homo sapiens_hsa030100.94004124
69mRNA surveillance pathway_Homo sapiens_hsa030150.91589370
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87002732
71Sulfur relay system_Homo sapiens_hsa041220.86931358
72Nucleotide excision repair_Homo sapiens_hsa034200.85788712
73Alzheimers disease_Homo sapiens_hsa050100.84219504
74Carbon metabolism_Homo sapiens_hsa012000.83592996
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.82601724
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82161327
77Complement and coagulation cascades_Homo sapiens_hsa046100.80494369
78Parkinsons disease_Homo sapiens_hsa050120.79910006
79Nitrogen metabolism_Homo sapiens_hsa009100.78125837
80Arginine and proline metabolism_Homo sapiens_hsa003300.75842915
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.75268835
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75072967
83Fatty acid metabolism_Homo sapiens_hsa012120.74091218
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72540484
85beta-Alanine metabolism_Homo sapiens_hsa004100.72138367
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71704480
87Arginine biosynthesis_Homo sapiens_hsa002200.71506658
88Purine metabolism_Homo sapiens_hsa002300.70205171
89Steroid biosynthesis_Homo sapiens_hsa001000.68853615
90Retinol metabolism_Homo sapiens_hsa008300.66323631
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65521767
92Fatty acid elongation_Homo sapiens_hsa000620.64872544
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.64862432
94Wnt signaling pathway_Homo sapiens_hsa043100.64232897
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.62456285
96Propanoate metabolism_Homo sapiens_hsa006400.62034498
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61625244
98Vibrio cholerae infection_Homo sapiens_hsa051100.61327785
99Hippo signaling pathway_Homo sapiens_hsa043900.59689557
100Thyroid hormone synthesis_Homo sapiens_hsa049180.59006477
101Gastric acid secretion_Homo sapiens_hsa049710.57150408
102p53 signaling pathway_Homo sapiens_hsa041150.55624996
103ABC transporters_Homo sapiens_hsa020100.54271742
104Hepatitis C_Homo sapiens_hsa051600.52157096
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51638957
106Oocyte meiosis_Homo sapiens_hsa041140.50525033
107Salivary secretion_Homo sapiens_hsa049700.50351179
108Circadian rhythm_Homo sapiens_hsa047100.50036440
109Cardiac muscle contraction_Homo sapiens_hsa042600.49814380
110Lysine degradation_Homo sapiens_hsa003100.48297983
111* Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47630278
112Fanconi anemia pathway_Homo sapiens_hsa034600.47214338
113Thyroid cancer_Homo sapiens_hsa052160.46043464
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.43742029
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43532292
116Sphingolipid metabolism_Homo sapiens_hsa006000.42849428
117Huntingtons disease_Homo sapiens_hsa050160.42785679
118Fatty acid biosynthesis_Homo sapiens_hsa000610.39982972
119Peroxisome_Homo sapiens_hsa041460.39543589
120Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39506115
121Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39475053
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.39020831
123Phenylalanine metabolism_Homo sapiens_hsa003600.38116114
124Metabolic pathways_Homo sapiens_hsa011000.37512269
125Salmonella infection_Homo sapiens_hsa051320.37354460
126Renin secretion_Homo sapiens_hsa049240.34141412
127Selenocompound metabolism_Homo sapiens_hsa004500.34107387
128Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33433319
129Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32064844
130Amoebiasis_Homo sapiens_hsa051460.31550796
131Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30989048
132Drug metabolism - other enzymes_Homo sapiens_hsa009830.27322063
133Adherens junction_Homo sapiens_hsa045200.25650180
134Bladder cancer_Homo sapiens_hsa052190.21543854
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.21539002
136Pertussis_Homo sapiens_hsa051330.19868087
137Dorso-ventral axis formation_Homo sapiens_hsa043200.19089027
138Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.19069032
139Intestinal immune network for IgA production_Homo sapiens_hsa046720.14219730
140Tyrosine metabolism_Homo sapiens_hsa003500.13854981
141VEGF signaling pathway_Homo sapiens_hsa043700.12084535
142Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.10941891

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