CHST6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an enzyme that catalyzes the transfer of a sulfate group to the GlcNAc residues of keratan. Keratan sulfate helps maintain corneal transparency. Defects in this gene are a cause of macular corneal dystrophy (MCD). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.25774649
2cilium or flagellum-dependent cell motility (GO:0001539)8.36112392
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.79929104
4cilium movement (GO:0003341)7.61031687
5epithelial cilium movement (GO:0003351)7.25314588
6motile cilium assembly (GO:0044458)6.28283810
7axoneme assembly (GO:0035082)5.83023108
8behavioral response to nicotine (GO:0035095)5.14309750
9regulation of cilium movement (GO:0003352)4.57430333
10cilium organization (GO:0044782)4.11590960
11L-fucose catabolic process (GO:0042355)4.07164723
12fucose catabolic process (GO:0019317)4.07164723
13L-fucose metabolic process (GO:0042354)4.07164723
14left/right pattern formation (GO:0060972)3.97394383
15cilium assembly (GO:0042384)3.94464863
16cornea development in camera-type eye (GO:0061303)3.77302373
17left/right axis specification (GO:0070986)3.75463200
18intraciliary transport (GO:0042073)3.71394972
19cilium morphogenesis (GO:0060271)3.50643266
20protein localization to cilium (GO:0061512)3.49272435
21microtubule bundle formation (GO:0001578)3.44336360
22negative regulation of T cell differentiation in thymus (GO:0033085)3.40389941
23vitamin transmembrane transport (GO:0035461)3.39127246
24lateral sprouting from an epithelium (GO:0060601)3.38842135
25protein polyglutamylation (GO:0018095)3.38784111
26nonmotile primary cilium assembly (GO:0035058)3.33362873
27regulation of microtubule-based movement (GO:0060632)3.28901308
28primary alcohol catabolic process (GO:0034310)3.28792859
29lung epithelium development (GO:0060428)3.13994469
30one-carbon compound transport (GO:0019755)3.06071695
31detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.06057218
32cellular component assembly involved in morphogenesis (GO:0010927)3.05912127
33somite development (GO:0061053)2.97826418
34regulation of posttranscriptional gene silencing (GO:0060147)2.97535684
35regulation of gene silencing by miRNA (GO:0060964)2.97535684
36regulation of gene silencing by RNA (GO:0060966)2.97535684
37determination of left/right symmetry (GO:0007368)2.97266087
38response to pheromone (GO:0019236)2.97027909
39water-soluble vitamin biosynthetic process (GO:0042364)2.96367278
40kidney morphogenesis (GO:0060993)2.92790106
41sulfation (GO:0051923)2.90201855
42exogenous drug catabolic process (GO:0042738)2.89791501
43regulation of collateral sprouting (GO:0048670)2.88719148
44positive regulation of oligodendrocyte differentiation (GO:0048714)2.86001357
45retinal cone cell development (GO:0046549)2.85936061
46response to xenobiotic stimulus (GO:0009410)2.82380970
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.81255727
48DNA deamination (GO:0045006)2.80478965
49ventricular system development (GO:0021591)2.78108350
50determination of bilateral symmetry (GO:0009855)2.77235475
51spinal cord motor neuron differentiation (GO:0021522)2.76591709
52regulation of mesoderm development (GO:2000380)2.74320393
53kynurenine metabolic process (GO:0070189)2.73530289
54indolalkylamine metabolic process (GO:0006586)2.72044241
55photoreceptor cell maintenance (GO:0045494)2.71335394
56smoothened signaling pathway (GO:0007224)2.70085550
57specification of symmetry (GO:0009799)2.69410817
58negative regulation of telomere maintenance (GO:0032205)2.67507253
59behavioral response to ethanol (GO:0048149)2.67130393
60negative regulation of cytosolic calcium ion concentration (GO:0051481)2.66549436
61negative regulation of synaptic transmission, GABAergic (GO:0032229)2.66537549
62drug catabolic process (GO:0042737)2.66518713
63rRNA catabolic process (GO:0016075)2.66030916
64tryptophan catabolic process (GO:0006569)2.65907942
65indole-containing compound catabolic process (GO:0042436)2.65907942
66indolalkylamine catabolic process (GO:0046218)2.65907942
67sperm motility (GO:0030317)2.65781383
68gamma-aminobutyric acid transport (GO:0015812)2.64998897
69centriole assembly (GO:0098534)2.63893982
70retinoic acid metabolic process (GO:0042573)2.63109451
71diterpenoid biosynthetic process (GO:0016102)2.60845767
72transmission of nerve impulse (GO:0019226)2.59910114
73cell projection assembly (GO:0030031)2.58857157
74regulation of hippo signaling (GO:0035330)2.55933501
75cellular ketone body metabolic process (GO:0046950)2.53417512
76centriole replication (GO:0007099)2.46855844
77ethanol metabolic process (GO:0006067)2.46832125
78otic vesicle formation (GO:0030916)2.45750127
79mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.44760692
80mitochondrial respiratory chain complex I assembly (GO:0032981)2.44760692
81NADH dehydrogenase complex assembly (GO:0010257)2.44760692
82limb development (GO:0060173)2.44491626
83appendage development (GO:0048736)2.44491626
84negative regulation of transcription regulatory region DNA binding (GO:2000678)2.43431362
85pyrimidine-containing compound transmembrane transport (GO:0072531)2.42978839
86cellular response to ATP (GO:0071318)2.41361381
87terpenoid biosynthetic process (GO:0016114)2.38227785
88nephron epithelium morphogenesis (GO:0072088)2.36421896
89nephron tubule morphogenesis (GO:0072078)2.36421896
90detection of light stimulus involved in visual perception (GO:0050908)2.36082070
91detection of light stimulus involved in sensory perception (GO:0050962)2.36082070
92protein complex biogenesis (GO:0070271)2.35196629
93benzene-containing compound metabolic process (GO:0042537)2.35056097
94reflex (GO:0060004)2.34901967
95neuronal action potential (GO:0019228)2.34643493
96nucleoside diphosphate phosphorylation (GO:0006165)2.34146172
97cell proliferation in forebrain (GO:0021846)2.33735235
98photoreceptor cell development (GO:0042461)2.33598741
99piRNA metabolic process (GO:0034587)2.32032300
100ketone body metabolic process (GO:1902224)2.29411814

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.49288025
2VDR_22108803_ChIP-Seq_LS180_Human3.11700955
3EZH2_22144423_ChIP-Seq_EOC_Human2.68116576
4GBX2_23144817_ChIP-Seq_PC3_Human2.65303919
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.42875918
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.16947026
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.13267337
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08825734
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01378582
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.00045196
11IGF1R_20145208_ChIP-Seq_DFB_Human1.79465441
12FUS_26573619_Chip-Seq_HEK293_Human1.78791581
13FLI1_27457419_Chip-Seq_LIVER_Mouse1.78756977
14PIAS1_25552417_ChIP-Seq_VCAP_Human1.74099464
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.72000755
16P300_19829295_ChIP-Seq_ESCs_Human1.70132582
17EWS_26573619_Chip-Seq_HEK293_Human1.69843189
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67756391
19DROSHA_22980978_ChIP-Seq_HELA_Human1.67213404
20BMI1_23680149_ChIP-Seq_NPCS_Mouse1.63850815
21NR3C1_21868756_ChIP-Seq_MCF10A_Human1.62584709
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.61064710
23TAF15_26573619_Chip-Seq_HEK293_Human1.59710598
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.58995790
25REST_21632747_ChIP-Seq_MESCs_Mouse1.58890156
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54145368
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53202231
28ER_23166858_ChIP-Seq_MCF-7_Human1.51376855
29* STAT3_23295773_ChIP-Seq_U87_Human1.50776272
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50690250
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50664093
32IRF1_19129219_ChIP-ChIP_H3396_Human1.49002032
33SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48162026
34SMAD4_21799915_ChIP-Seq_A2780_Human1.47120728
35BCAT_22108803_ChIP-Seq_LS180_Human1.46288364
36TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43487681
37POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43339243
38TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43339243
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.42548309
40AR_21572438_ChIP-Seq_LNCaP_Human1.41682651
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.40796871
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40038419
43TCF4_23295773_ChIP-Seq_U87_Human1.37938397
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36192241
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.35352857
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34511121
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.32504852
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32504852
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.32100360
50EED_16625203_ChIP-ChIP_MESCs_Mouse1.30911671
51AR_25329375_ChIP-Seq_VCAP_Human1.29845101
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29280786
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28916952
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28473146
55SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.28459827
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.28201207
57TCF4_22108803_ChIP-Seq_LS180_Human1.27962554
58MYC_18940864_ChIP-ChIP_HL60_Human1.27915097
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26932598
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26831123
61SMAD4_21741376_ChIP-Seq_EPCs_Human1.25717212
62GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24411030
63CBP_20019798_ChIP-Seq_JUKART_Human1.24373704
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24373704
65JARID2_20064375_ChIP-Seq_MESCs_Mouse1.20928354
66TP53_22573176_ChIP-Seq_HFKS_Human1.19574497
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19357183
68NANOG_19829295_ChIP-Seq_ESCs_Human1.18398746
69SOX2_19829295_ChIP-Seq_ESCs_Human1.18398746
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.18277120
71JARID2_20075857_ChIP-Seq_MESCs_Mouse1.17722911
72RUNX2_22187159_ChIP-Seq_PCA_Human1.17039911
73GATA3_21878914_ChIP-Seq_MCF-7_Human1.16233512
74NCOR_22424771_ChIP-Seq_293T_Human1.15995810
75SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.15926317
76RNF2_27304074_Chip-Seq_NSC_Mouse1.15461418
77EZH2_27304074_Chip-Seq_ESCs_Mouse1.13795553
78SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12385823
79AR_20517297_ChIP-Seq_VCAP_Human1.09218158
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09213710
81TDRD3_21172665_ChIP-Seq_MCF-7_Human1.08960453
82SMAD3_21741376_ChIP-Seq_ESCs_Human1.08958090
83HOXB7_26014856_ChIP-Seq_BT474_Human1.07620725
84PRDM14_20953172_ChIP-Seq_ESCs_Human1.06861257
85SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06726349
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.05528994
87FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05522165
88SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.05129939
89PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04561398
90TP53_16413492_ChIP-PET_HCT116_Human1.04422194
91SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03782008
92MYC_19829295_ChIP-Seq_ESCs_Human1.03289547
93FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02858718
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02418446
95RNF2_27304074_Chip-Seq_ESCs_Mouse1.02279547
96RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02251786
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02237926
98ETV1_20927104_ChIP-Seq_GIST48_Human1.00958563
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99523993
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98948586

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok3.64612040
2MP0002653_abnormal_ependyma_morphology3.35326079
3MP0004133_heterotaxia2.82040004
4MP0005377_hearing/vestibular/ear_phenot2.54405185
5MP0003878_abnormal_ear_physiology2.54405185
6MP0001485_abnormal_pinna_reflex2.53019846
7MP0002102_abnormal_ear_morphology2.51746702
8MP0004885_abnormal_endolymph2.51500997
9MP0004043_abnormal_pH_regulation2.42650444
10MP0003136_yellow_coat_color2.33799446
11MP0005551_abnormal_eye_electrophysiolog2.23085569
12MP0005646_abnormal_pituitary_gland2.22515582
13MP0001984_abnormal_olfaction2.21812443
14MP0003195_calcinosis2.01574134
15MP0006292_abnormal_olfactory_placode2.01350106
16MP0009046_muscle_twitch1.97738122
17MP0002876_abnormal_thyroid_physiology1.92022697
18MP0009745_abnormal_behavioral_response1.88800508
19MP0001968_abnormal_touch/_nociception1.84067519
20MP0008877_abnormal_DNA_methylation1.80390586
21MP0002277_abnormal_respiratory_mucosa1.75440812
22MP0003646_muscle_fatigue1.74538043
23MP0002837_dystrophic_cardiac_calcinosis1.70059546
24MP0000631_abnormal_neuroendocrine_gland1.68016510
25MP0002272_abnormal_nervous_system1.66543169
26MP0002160_abnormal_reproductive_system1.64971143
27MP0003283_abnormal_digestive_organ1.62338336
28MP0002736_abnormal_nociception_after1.57810352
29MP0005253_abnormal_eye_physiology1.56694254
30MP0008872_abnormal_physiological_respon1.55934792
31MP0006072_abnormal_retinal_apoptosis1.54859572
32MP0001486_abnormal_startle_reflex1.51345791
33MP0000383_abnormal_hair_follicle1.49879869
34MP0002735_abnormal_chemical_nociception1.44661252
35MP0000566_synostosis1.42821917
36MP0000049_abnormal_middle_ear1.41748511
37MP0008789_abnormal_olfactory_epithelium1.41398710
38MP0003119_abnormal_digestive_system1.40704017
39MP0004742_abnormal_vestibular_system1.40429454
40MP0002064_seizures1.39569884
41MP0004019_abnormal_vitamin_homeostasis1.37567542
42MP0003890_abnormal_embryonic-extraembry1.35692945
43MP0009780_abnormal_chondrocyte_physiolo1.35219978
44MP0003937_abnormal_limbs/digits/tail_de1.35073010
45MP0002572_abnormal_emotion/affect_behav1.32556043
46MP0002638_abnormal_pupillary_reflex1.30437878
47MP0002734_abnormal_mechanical_nocicepti1.29538840
48MP0004142_abnormal_muscle_tone1.28801481
49MP0003938_abnormal_ear_development1.24966846
50MP0002938_white_spotting1.24635788
51MP0000026_abnormal_inner_ear1.23355812
52MP0001970_abnormal_pain_threshold1.22390893
53MP0002557_abnormal_social/conspecific_i1.21802859
54MP0001963_abnormal_hearing_physiology1.20491518
55MP0001293_anophthalmia1.19327529
56MP0005389_reproductive_system_phenotype1.18382545
57MP0004147_increased_porphyrin_level1.17667899
58MP0001501_abnormal_sleep_pattern1.17445782
59MP0006276_abnormal_autonomic_nervous1.15541378
60MP0003635_abnormal_synaptic_transmissio1.15077840
61MP0005195_abnormal_posterior_eye1.14841509
62MP0002909_abnormal_adrenal_gland1.12278772
63MP0003011_delayed_dark_adaptation1.12146195
64MP0002063_abnormal_learning/memory/cond1.10784565
65MP0003880_abnormal_central_pattern1.08864560
66MP0002733_abnormal_thermal_nociception1.07995534
67MP0005645_abnormal_hypothalamus_physiol1.06838644
68MP0001502_abnormal_circadian_rhythm1.06097512
69MP0009379_abnormal_foot_pigmentation1.05059305
70MP0000778_abnormal_nervous_system1.02935309
71MP0000427_abnormal_hair_cycle0.99578418
72MP0001986_abnormal_taste_sensitivity0.98280299
73MP0010030_abnormal_orbit_morphology0.97167224
74MP0002282_abnormal_trachea_morphology0.96756148
75MP0003718_maternal_effect0.94918634
76MP0003787_abnormal_imprinting0.94917086
77MP0000569_abnormal_digit_pigmentation0.94810594
78MP0004145_abnormal_muscle_electrophysio0.94633545
79MP0002752_abnormal_somatic_nervous0.94043091
80MP0002067_abnormal_sensory_capabilities0.90279154
81MP0001905_abnormal_dopamine_level0.88034648
82MP0005394_taste/olfaction_phenotype0.84749991
83MP0005499_abnormal_olfactory_system0.84749991
84MP0002229_neurodegeneration0.84601897
85MP0005174_abnormal_tail_pigmentation0.84266804
86MP0000955_abnormal_spinal_cord0.82450910
87MP0005391_vision/eye_phenotype0.82320250
88MP0003698_abnormal_male_reproductive0.81834928
89MP0001324_abnormal_eye_pigmentation0.80658303
90MP0001765_abnormal_ion_homeostasis0.80488656
91MP0004924_abnormal_behavior0.79579356
92MP0005386_behavior/neurological_phenoty0.79579356
93MP0000372_irregular_coat_pigmentation0.79120137
94MP0002882_abnormal_neuron_morphology0.78277750
95MP0001188_hyperpigmentation0.77942901
96MP0010678_abnormal_skin_adnexa0.77746025
97MP0001529_abnormal_vocalization0.77631721
98MP0004215_abnormal_myocardial_fiber0.76031907
99MP0002184_abnormal_innervation0.72983491
100MP0000230_abnormal_systemic_arterial0.72850904

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)6.98095531
2Absent/shortened dynein arms (HP:0200106)6.98095531
3Abnormal respiratory motile cilium morphology (HP:0005938)6.92007557
4Abnormal respiratory epithelium morphology (HP:0012253)6.92007557
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.76849650
6Abnormal ciliary motility (HP:0012262)6.55227721
7Abnormal respiratory motile cilium physiology (HP:0012261)6.41072141
8Rhinitis (HP:0012384)5.74676432
9Chronic bronchitis (HP:0004469)4.61764790
10Pancreatic fibrosis (HP:0100732)4.59580077
11True hermaphroditism (HP:0010459)4.54098707
12Pancreatic cysts (HP:0001737)4.54008281
13Molar tooth sign on MRI (HP:0002419)4.32550971
14Abnormality of midbrain morphology (HP:0002418)4.32550971
15Bronchiectasis (HP:0002110)4.20140318
16Nephronophthisis (HP:0000090)4.02202036
17Cystic liver disease (HP:0006706)3.43147659
18Abnormality of the renal medulla (HP:0100957)3.36864512
19Chronic hepatic failure (HP:0100626)3.09108346
20Occipital encephalocele (HP:0002085)2.91449849
21Congenital stationary night blindness (HP:0007642)2.83300238
22Tubular atrophy (HP:0000092)2.82345848
23Abnormality of the renal cortex (HP:0011035)2.68752672
24Decreased circulating renin level (HP:0003351)2.67985082
25Medial flaring of the eyebrow (HP:0010747)2.67044113
26Anencephaly (HP:0002323)2.62963175
27Postaxial foot polydactyly (HP:0001830)2.60929618
28Sclerocornea (HP:0000647)2.59829339
29Pendular nystagmus (HP:0012043)2.58822559
30Nasal polyposis (HP:0100582)2.56666903
31Abolished electroretinogram (ERG) (HP:0000550)2.43837801
32Aplasia/Hypoplasia of the tongue (HP:0010295)2.40751276
33Male pseudohermaphroditism (HP:0000037)2.39324486
34Attenuation of retinal blood vessels (HP:0007843)2.38231673
35Infertility (HP:0000789)2.37174111
36Chronic sinusitis (HP:0011109)2.37026308
37Congenital hepatic fibrosis (HP:0002612)2.34311199
38Aplasia/Hypoplasia of the spleen (HP:0010451)2.32027444
39Gait imbalance (HP:0002141)2.25872546
40Furrowed tongue (HP:0000221)2.25856127
41Type II lissencephaly (HP:0007260)2.24173553
42Abnormal drinking behavior (HP:0030082)2.24086878
43Polydipsia (HP:0001959)2.24086878
44Decreased central vision (HP:0007663)2.24062265
45Bronchitis (HP:0012387)2.19375831
46Congenital primary aphakia (HP:0007707)2.17256462
47Asplenia (HP:0001746)2.16079157
48Recurrent sinusitis (HP:0011108)2.15480704
49Absent rod-and cone-mediated responses on ERG (HP:0007688)2.08287714
50Abnormal rod and cone electroretinograms (HP:0008323)2.04432951
51Increased corneal curvature (HP:0100692)2.03420023
52Keratoconus (HP:0000563)2.03420023
53Nephrogenic diabetes insipidus (HP:0009806)1.99235982
54Preaxial hand polydactyly (HP:0001177)1.98457540
55Abnormality of alanine metabolism (HP:0010916)1.97432628
56Hyperalaninemia (HP:0003348)1.97432628
57Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.97432628
58Abnormality of renin-angiotensin system (HP:0000847)1.95890682
59Postaxial hand polydactyly (HP:0001162)1.90646667
60Abnormality of the nasal mucosa (HP:0000433)1.87174621
61Hyperventilation (HP:0002883)1.85994031
62Genital tract atresia (HP:0001827)1.85559480
63Vaginal atresia (HP:0000148)1.84606012
64Hyperactive renin-angiotensin system (HP:0000841)1.83450660
65Broad-based gait (HP:0002136)1.82123532
66Genetic anticipation (HP:0003743)1.80713790
67Bile duct proliferation (HP:0001408)1.80386423
68Abnormal biliary tract physiology (HP:0012439)1.80386423
69Bilateral microphthalmos (HP:0007633)1.79967902
70Abnormality of the middle phalanges of the toes (HP:0010183)1.78495252
71Progressive cerebellar ataxia (HP:0002073)1.75743966
72Carpal bone hypoplasia (HP:0001498)1.73995631
73Renal salt wasting (HP:0000127)1.73710940
74Polyuria (HP:0000103)1.73311091
75Chronic otitis media (HP:0000389)1.71377846
76Hyperaldosteronism (HP:0000859)1.70580795
77Concave nail (HP:0001598)1.70056549
78Anophthalmia (HP:0000528)1.69850487
79Supernumerary spleens (HP:0009799)1.65520522
80Congenital, generalized hypertrichosis (HP:0004540)1.62483564
81Retinitis pigmentosa (HP:0000510)1.58279218
82Oculomotor apraxia (HP:0000657)1.58044921
83Congenital sensorineural hearing impairment (HP:0008527)1.57779376
84Gaze-evoked nystagmus (HP:0000640)1.57496599
85Aplasia/hypoplasia of the uterus (HP:0008684)1.56851096
86Protruding tongue (HP:0010808)1.56849583
87Patellar aplasia (HP:0006443)1.55851480
88Aplasia/Hypoplasia of the patella (HP:0006498)1.54935093
893-Methylglutaconic aciduria (HP:0003535)1.54642967
90Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.54547081
91Hypoplasia of the uterus (HP:0000013)1.53452024
92Abnormality of the labia minora (HP:0012880)1.53195005
93Poor coordination (HP:0002370)1.52871750
94Tubulointerstitial nephritis (HP:0001970)1.52560888
95Bony spicule pigmentary retinopathy (HP:0007737)1.51586341
96Short hallux (HP:0010109)1.49999718
97Chorioretinal atrophy (HP:0000533)1.49028098
98Stage 5 chronic kidney disease (HP:0003774)1.48097373
99Focal motor seizures (HP:0011153)1.46416577
100Abnormality of macular pigmentation (HP:0008002)1.46182455

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.00191655
2MAPK154.47872969
3INSRR4.02892370
4ADRBK23.20028524
5BMPR1B2.70754698
6GRK12.64269864
7TLK12.53514662
8WNK42.46071153
9ZAK2.31519540
10ACVR1B2.28967061
11WNK32.12435437
12MAP4K22.07865146
13PINK11.99166757
14OXSR11.73250367
15MST41.71774554
16CASK1.69803864
17NUAK11.64823466
18STK391.64142911
19MAPK131.54917209
20MKNK21.53791176
21DAPK21.41752607
22MAP3K41.35632154
23STK38L1.30296763
24DYRK21.28127954
25PNCK1.22087091
26ADRBK11.22023361
27MAPKAPK31.18281176
28FGFR21.08815474
29NME11.08151933
30TNIK1.04914134
31PRKCG1.00372412
32STK160.94787823
33EPHA40.94295845
34LATS10.93608682
35PHKG10.91596142
36PHKG20.91596142
37PTK2B0.88291253
38MARK10.85814003
39BRSK20.83963189
40TAOK30.82150317
41NTRK30.81013549
42TXK0.80669541
43CAMKK20.80312106
44PRKCE0.80265380
45TGFBR10.79543341
46MKNK10.79137870
47NTRK20.76650115
48CSNK1G20.75337401
49PLK20.74057507
50PAK30.73705010
51MAPKAPK50.73267514
52TIE10.72824935
53NLK0.72637661
54WEE10.69995856
55PRKCI0.68496965
56MAP2K70.67596860
57CSNK1G10.67041325
58PRKCQ0.66772231
59VRK10.66445439
60MUSK0.65513591
61STK30.65481250
62STK110.63096835
63EPHA20.61887360
64CAMK2A0.58807001
65NEK20.58377714
66CDK190.58113256
67IRAK10.57681532
68ERBB20.55340282
69PRKACA0.55169610
70PLK10.54902344
71TTK0.54216415
72CSNK1G30.53496251
73MAP2K20.52846952
74CSNK1A10.49670209
75BCR0.49445881
76CAMKK10.47931839
77RPS6KA50.47907777
78PIK3CA0.47272456
79TSSK60.46841113
80CSNK1A1L0.46360080
81PRKCA0.46325516
82CAMK10.45412345
83CHEK20.43007067
84PLK30.40404051
85PRKCZ0.39974891
86VRK20.39507909
87PKN10.38800288
88DYRK1A0.38210189
89PRKAA20.36208947
90SGK10.35847026
91MAP2K60.35594636
92CSNK1D0.35475133
93CDC70.35068615
94PLK40.33674626
95EPHA30.33555615
96BCKDK0.33063641
97CAMK1D0.30949976
98ATR0.30349931
99KIT0.30106491
100SGK2230.29462490

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.16425865
2Phototransduction_Homo sapiens_hsa047442.67381008
3Linoleic acid metabolism_Homo sapiens_hsa005912.63383123
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.53561690
5Histidine metabolism_Homo sapiens_hsa003402.41814074
6Nicotine addiction_Homo sapiens_hsa050332.38902408
7Nitrogen metabolism_Homo sapiens_hsa009102.38420178
8Chemical carcinogenesis_Homo sapiens_hsa052042.30321465
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.28133963
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.14482752
11Caffeine metabolism_Homo sapiens_hsa002322.13986635
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.12548499
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.12081576
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.88233472
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.87122433
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82258169
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.78021837
18Tryptophan metabolism_Homo sapiens_hsa003801.74435144
19beta-Alanine metabolism_Homo sapiens_hsa004101.70559279
20Selenocompound metabolism_Homo sapiens_hsa004501.68503269
21Butanoate metabolism_Homo sapiens_hsa006501.67319777
22Ether lipid metabolism_Homo sapiens_hsa005651.60212093
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.58113397
24Retinol metabolism_Homo sapiens_hsa008301.57621421
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.54211975
26Huntingtons disease_Homo sapiens_hsa050161.53641354
27Oxidative phosphorylation_Homo sapiens_hsa001901.45232718
28Taste transduction_Homo sapiens_hsa047421.44498198
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.43863182
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.37152187
31Tyrosine metabolism_Homo sapiens_hsa003501.30230570
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.28974612
33Olfactory transduction_Homo sapiens_hsa047401.25859544
34Homologous recombination_Homo sapiens_hsa034401.21422713
35Morphine addiction_Homo sapiens_hsa050321.21044718
36RNA polymerase_Homo sapiens_hsa030201.16183277
37Arachidonic acid metabolism_Homo sapiens_hsa005901.11722453
38ABC transporters_Homo sapiens_hsa020101.11484710
39Peroxisome_Homo sapiens_hsa041461.09107959
40Phenylalanine metabolism_Homo sapiens_hsa003601.07127226
41Basal transcription factors_Homo sapiens_hsa030221.07106137
42Fanconi anemia pathway_Homo sapiens_hsa034601.04556994
43* Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03289091
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02042000
45Insulin secretion_Homo sapiens_hsa049111.01862445
46Glutamatergic synapse_Homo sapiens_hsa047241.01065194
47Cardiac muscle contraction_Homo sapiens_hsa042600.98463583
48Basal cell carcinoma_Homo sapiens_hsa052170.97210562
49Salivary secretion_Homo sapiens_hsa049700.96663291
50Circadian entrainment_Homo sapiens_hsa047130.95914198
51Serotonergic synapse_Homo sapiens_hsa047260.92168935
52GABAergic synapse_Homo sapiens_hsa047270.91108368
53Parkinsons disease_Homo sapiens_hsa050120.89875808
54Ovarian steroidogenesis_Homo sapiens_hsa049130.85426896
55Hedgehog signaling pathway_Homo sapiens_hsa043400.84365595
56Glycerolipid metabolism_Homo sapiens_hsa005610.82962868
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.82887898
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.82730260
59Protein export_Homo sapiens_hsa030600.77700469
60Calcium signaling pathway_Homo sapiens_hsa040200.77449181
61Propanoate metabolism_Homo sapiens_hsa006400.77318515
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77201332
63One carbon pool by folate_Homo sapiens_hsa006700.74970658
64Alzheimers disease_Homo sapiens_hsa050100.72387204
65Fatty acid degradation_Homo sapiens_hsa000710.70292419
66Vitamin digestion and absorption_Homo sapiens_hsa049770.68155756
67RNA degradation_Homo sapiens_hsa030180.67027414
68Glutathione metabolism_Homo sapiens_hsa004800.66705561
69Fat digestion and absorption_Homo sapiens_hsa049750.64823162
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.64391593
71Metabolic pathways_Homo sapiens_hsa011000.64240843
72Purine metabolism_Homo sapiens_hsa002300.61281698
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60768063
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59649966
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.56518867
76Cocaine addiction_Homo sapiens_hsa050300.55695158
77Arginine and proline metabolism_Homo sapiens_hsa003300.55014023
78Fatty acid biosynthesis_Homo sapiens_hsa000610.54359032
79Sulfur metabolism_Homo sapiens_hsa009200.53722842
80cAMP signaling pathway_Homo sapiens_hsa040240.50042006
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.50020623
82Collecting duct acid secretion_Homo sapiens_hsa049660.48988496
83Mineral absorption_Homo sapiens_hsa049780.48620032
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48123842
85Sulfur relay system_Homo sapiens_hsa041220.46705743
86Amphetamine addiction_Homo sapiens_hsa050310.45769448
87Hippo signaling pathway_Homo sapiens_hsa043900.45504003
88Sphingolipid metabolism_Homo sapiens_hsa006000.44862770
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.44130058
90Regulation of autophagy_Homo sapiens_hsa041400.42942423
91Gastric acid secretion_Homo sapiens_hsa049710.42679470
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.41653379
93Ribosome_Homo sapiens_hsa030100.40504512
94Bile secretion_Homo sapiens_hsa049760.40189129
95Long-term depression_Homo sapiens_hsa047300.40003887
96Dopaminergic synapse_Homo sapiens_hsa047280.38463096
97Axon guidance_Homo sapiens_hsa043600.36603042
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33909264
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33122473
100Pyrimidine metabolism_Homo sapiens_hsa002400.32357162

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