CHST7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the Gal/GalNAc/GlcNAc (galactose/N-acetylgalactosamine/N-acetylglucosamine) 6-O-sulfotransferase (GST) family. Members of this family encode enzymes that catalyze the specific addition of sulfate groups to distinct hydroxyl and amino groups of carbohydrates. The encoded protein catalyzes the sulfation of 6-hydroxyl group of GalNAc in chondroitin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of interleukin-12 production (GO:0032695)5.12687268
2response to peptidoglycan (GO:0032494)5.04260339
3vascular endothelial growth factor signaling pathway (GO:0038084)4.89963156
4regulation of vitamin D biosynthetic process (GO:0060556)4.88248211
5lipopolysaccharide-mediated signaling pathway (GO:0031663)4.47297174
6positive regulation of heat generation (GO:0031652)4.29390790
7regulation of fever generation (GO:0031620)4.18739989
8cellular response to vascular endothelial growth factor stimulus (GO:0035924)4.14166447
9lymphangiogenesis (GO:0001946)4.13879951
10lymph vessel development (GO:0001945)4.02134588
11NIK/NF-kappaB signaling (GO:0038061)4.00721658
12positive regulation of chemokine biosynthetic process (GO:0045080)4.00045887
13regulation of dendritic cell antigen processing and presentation (GO:0002604)3.94236532
14Notch signaling involved in heart development (GO:0061314)3.91492863
15microglial cell activation (GO:0001774)3.91010141
16detection of molecule of bacterial origin (GO:0032490)3.90101566
17positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.87333214
18T-helper 1 type immune response (GO:0042088)3.83751504
19regulation of mononuclear cell migration (GO:0071675)3.82929584
20regulation of cytokine secretion involved in immune response (GO:0002739)3.78840984
21positive regulation of astrocyte differentiation (GO:0048711)3.68299771
22negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.66947135
23regulation of podosome assembly (GO:0071801)3.66853943
24regulation of vitamin metabolic process (GO:0030656)3.63337054
25myeloid dendritic cell differentiation (GO:0043011)3.62460095
26regulation of chronic inflammatory response (GO:0002676)3.59837023
27regulation of chemokine biosynthetic process (GO:0045073)3.58119876
28neutrophil activation involved in immune response (GO:0002283)3.57275669
29endothelium development (GO:0003158)3.54083017
30negative regulation of nitric oxide biosynthetic process (GO:0045019)3.51400251
31negative regulation of cytokine production involved in immune response (GO:0002719)3.51264557
32regulation of membrane protein ectodomain proteolysis (GO:0051043)3.51122153
33leukocyte tethering or rolling (GO:0050901)3.47682064
34positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.46123233
35hyaluronan catabolic process (GO:0030214)3.44572643
36negative regulation of smooth muscle cell migration (GO:0014912)3.41602028
37basement membrane organization (GO:0071711)3.38391435
38keratan sulfate catabolic process (GO:0042340)3.37222384
39cell adhesion mediated by integrin (GO:0033627)3.36980402
40sexual reproduction (GO:0019953)3.34201778
41chondroitin sulfate catabolic process (GO:0030207)3.32247381
42monocyte chemotaxis (GO:0002548)3.32037895
43type I interferon signaling pathway (GO:0060337)3.31626409
44cellular response to type I interferon (GO:0071357)3.31626409
45positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.30545716
46positive regulation of NF-kappaB import into nucleus (GO:0042346)3.28579181
47positive regulation of interferon-alpha production (GO:0032727)3.28185092
48growth hormone receptor signaling pathway (GO:0060396)3.27771597
49cell migration involved in gastrulation (GO:0042074)3.27186926
50macrophage activation involved in immune response (GO:0002281)3.26135110
51response to type I interferon (GO:0034340)3.23808166
52regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.23299208
53endodermal cell differentiation (GO:0035987)3.23288618
54positive regulation of gamma-delta T cell activation (GO:0046645)3.23067997
55response to protozoan (GO:0001562)3.22200457
56regulation of interferon-beta biosynthetic process (GO:0045357)3.21723558
57positive regulation of antigen processing and presentation (GO:0002579)3.21529414
58germinal center formation (GO:0002467)3.21396190
59negative regulation of myeloid cell apoptotic process (GO:0033033)3.20600577
60morphogenesis of an endothelium (GO:0003159)3.20299525
61endothelial tube morphogenesis (GO:0061154)3.20299525
62ruffle organization (GO:0031529)3.18873354
63glycosphingolipid catabolic process (GO:0046479)3.18744121
64regulation of macrophage chemotaxis (GO:0010758)3.16770260
65low-density lipoprotein particle clearance (GO:0034383)3.16014708
66immunoglobulin mediated immune response (GO:0016064)3.14956377
67regulation of T-helper 1 cell differentiation (GO:0045625)3.14270137
68cellular response to lipopolysaccharide (GO:0071222)3.13001503
69dermatan sulfate metabolic process (GO:0030205)3.11886247
70positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.11395331
71regulation of interferon-alpha production (GO:0032647)3.09831071
72defense response to protozoan (GO:0042832)3.09215973
73wound healing, spreading of epidermal cells (GO:0035313)3.08822719
74regulation of heat generation (GO:0031650)3.08499055
75myeloid dendritic cell activation (GO:0001773)3.08342375
76regulation of nitric oxide biosynthetic process (GO:0045428)3.08278583
77regulation of T-helper 2 cell differentiation (GO:0045628)3.06782652
78cellular response to molecule of bacterial origin (GO:0071219)3.05820347
79regulation of cholesterol storage (GO:0010885)3.04110384
80adhesion of symbiont to host (GO:0044406)3.03769167
81positive regulation by symbiont of host defense response (GO:0052509)3.01601984
82modulation by symbiont of host defense response (GO:0052031)3.01601984
83modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.01601984
84modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.01601984
85positive regulation by organism of defense response of other organism involved in symbiotic interact3.01601984
86modulation by symbiont of host immune response (GO:0052553)3.01601984
87activation of MAPKKK activity (GO:0000185)3.00847396
88apoptotic cell clearance (GO:0043277)3.00506150
89positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.99704825
90cell migration involved in heart development (GO:0060973)2.98381645
91cellular response to thyroid hormone stimulus (GO:0097067)2.96797056
92negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.96220932
93negative regulation of cell killing (GO:0031342)2.96220932
94branching involved in salivary gland morphogenesis (GO:0060445)2.95653256
95oligosaccharide catabolic process (GO:0009313)2.95306185
96granulocyte activation (GO:0036230)2.95022274
97protein localization to endosome (GO:0036010)2.94733310
98branching involved in labyrinthine layer morphogenesis (GO:0060670)2.93434741
99positive regulation of epithelial to mesenchymal transition (GO:0010718)2.92932389
100positive regulation of interleukin-6 production (GO:0032755)2.92881041
101interferon-gamma-mediated signaling pathway (GO:0060333)2.92727078
102positive regulation of nitric oxide biosynthetic process (GO:0045429)2.91046715
103wound healing, spreading of cells (GO:0044319)2.90706719
104adhesion of symbiont to host cell (GO:0044650)2.90234375
105virion attachment to host cell (GO:0019062)2.90234375
106positive regulation of acute inflammatory response (GO:0002675)2.88783986
107detection of external biotic stimulus (GO:0098581)2.88396845
108regulation of interleukin-12 production (GO:0032655)2.87546526
109antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.86285316
110regulation of antigen processing and presentation (GO:0002577)2.85607006
111regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.84328116
112positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.83036049
113regulation of integrin-mediated signaling pathway (GO:2001044)2.82142519
114regulation of RIG-I signaling pathway (GO:0039535)2.79733504
115dendritic cell differentiation (GO:0097028)2.79522890
116negative regulation of production of molecular mediator of immune response (GO:0002701)2.79283792
117neuron projection extension involved in neuron projection guidance (GO:1902284)2.79137838
118axon extension involved in axon guidance (GO:0048846)2.79137838
119glycolipid catabolic process (GO:0019377)2.78626579
120positive regulation of type 2 immune response (GO:0002830)2.77289044
121regulation of NF-kappaB import into nucleus (GO:0042345)2.75890631
122response to muramyl dipeptide (GO:0032495)2.74969718
123amino sugar catabolic process (GO:0046348)2.74924237
124endothelial cell morphogenesis (GO:0001886)2.74688632
125retina vasculature morphogenesis in camera-type eye (GO:0061299)2.73722675
126dermatan sulfate biosynthetic process (GO:0030208)2.73459370
127negative regulation of lipid storage (GO:0010888)2.71227373
128regulation of interleukin-8 biosynthetic process (GO:0045414)2.71091027
129response to fluid shear stress (GO:0034405)2.70989194
130glial cell migration (GO:0008347)2.69587365
131detection of other organism (GO:0098543)2.69527949
132regulation of interleukin-6 production (GO:0032675)2.68941534
133regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.68014071
134positive regulation of natural killer cell differentiation (GO:0032825)2.67428106
135cellular response to biotic stimulus (GO:0071216)2.67137665
136regulation of tight junction assembly (GO:2000810)2.66504655
137urate metabolic process (GO:0046415)2.65868762
138vitamin catabolic process (GO:0009111)2.64611169
139fat-soluble vitamin catabolic process (GO:0042363)2.64611169
140regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.64372282
141regulation of interferon-gamma biosynthetic process (GO:0045072)2.63813961
142detection of biotic stimulus (GO:0009595)2.63477072
143positive regulation vascular endothelial growth factor production (GO:0010575)2.62711802
144cellular response to growth hormone stimulus (GO:0071378)2.62340874
145response to laminar fluid shear stress (GO:0034616)2.61360095
146vagina development (GO:0060068)2.60841143
147blood vessel endothelial cell migration (GO:0043534)2.59157761
148regulation of type I interferon-mediated signaling pathway (GO:0060338)2.58395819
149regulation of interleukin-2 biosynthetic process (GO:0045076)2.57862227
150antigen processing and presentation of endogenous antigen (GO:0019883)2.57577281
151positive regulation of interleukin-10 production (GO:0032733)2.57089246
152aorta morphogenesis (GO:0035909)2.56975964
153positive regulation of cellular amide metabolic process (GO:0034250)2.56924200
154positive regulation of interferon-beta production (GO:0032728)2.56863065
155regulation of type 2 immune response (GO:0002828)2.55891204
156positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.55640518
157regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.55170111
158positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.54834325
159regulation of chemokine-mediated signaling pathway (GO:0070099)2.53883443
160negative regulation of blood vessel endothelial cell migration (GO:0043537)2.51732053
161regulation of monocyte chemotaxis (GO:0090025)2.51048805
162vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.50206595
163macrophage chemotaxis (GO:0048246)2.48923578
164regulation of integrin activation (GO:0033623)2.48292741
165positive regulation of endothelial cell differentiation (GO:0045603)2.46106030
166cell migration involved in sprouting angiogenesis (GO:0002042)2.45482491
167substrate-dependent cell migration (GO:0006929)2.42447557
168regulation of interleukin-12 biosynthetic process (GO:0045075)2.41783966
169negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.37669798
170vasculogenesis (GO:0001570)2.36498558
171regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.36490692
172substrate adhesion-dependent cell spreading (GO:0034446)2.36417955
173surfactant homeostasis (GO:0043129)2.35786839
174regulation of endothelial cell differentiation (GO:0045601)2.34267542
175positive regulation of interleukin-12 production (GO:0032735)2.34246446
176regulation of macrophage cytokine production (GO:0010935)2.32606595
177macrophage activation (GO:0042116)2.32604865
178positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.32526576
179endothelial cell differentiation (GO:0045446)2.31873625
180positive regulation of adherens junction organization (GO:1903393)2.31139592
181positive regulation of cell junction assembly (GO:1901890)2.30338043
182positive regulation of focal adhesion assembly (GO:0051894)2.30338043
183patterning of blood vessels (GO:0001569)2.30211743

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.20359041
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.19209542
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.86066123
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.82021939
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.59659643
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.40017911
7RARG_19884340_ChIP-ChIP_MEFs_Mouse3.31285334
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.18103120
9CLOCK_20551151_ChIP-Seq_293T_Human2.98825575
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.95247015
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.86964944
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.85298498
13RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.75337101
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.49437199
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.47891959
16* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.38159496
17ELK3_25401928_ChIP-Seq_HUVEC_Human2.30627739
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.22142214
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.20530319
20ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.19554941
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.09654149
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.09443433
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.03963282
24RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.03842517
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.00910386
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98333264
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.98312843
28CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.87349396
29KDM2B_26808549_Chip-Seq_SUP-B15_Human1.84551342
30FOXM1_23109430_ChIP-Seq_U2OS_Human1.80527883
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.76240104
32SPI1_23547873_ChIP-Seq_NB4_Human1.74860923
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.71619990
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.65020625
35PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.64817261
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.59349364
37HIF1A_21447827_ChIP-Seq_MCF-7_Human1.58223091
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.56477212
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.54761327
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.53954751
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.52615649
42* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.51720137
43POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.50551351
44CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50170552
45CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.49914150
46TCF3_18692474_ChIP-Seq_MEFs_Mouse1.49358079
47VDR_24787735_ChIP-Seq_THP-1_Human1.47161821
48TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.45909705
49FOXO3_23340844_ChIP-Seq_DLD1_Human1.43813281
50ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.43711453
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.43406073
52CJUN_26792858_Chip-Seq_BT549_Human1.38776922
53KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.38312567
54KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.38312567
55KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.38312567
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.36743104
57JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36589943
58CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.34346280
59PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34259627
60TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33753681
61PU_27001747_Chip-Seq_BMDM_Mouse1.33210761
62SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32776508
63EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.32153090
64KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31810752
65RUNX_20019798_ChIP-Seq_JUKART_Human1.31683173
66WT1_19549856_ChIP-ChIP_CCG9911_Human1.31677614
67SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.31278513
68PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.31237577
69TBX20_22080862_ChIP-Seq_HEART_Mouse1.31080236
70TBX20_22328084_ChIP-Seq_HEART_Mouse1.31080236
71PPAR_26484153_Chip-Seq_NCI-H1993_Human1.30735344
72NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.28746760
73BRD4_27068464_Chip-Seq_AML-cells_Mouse1.28371484
74ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.28288511
75PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27942279
76ATF3_27146783_Chip-Seq_COLON_Human1.27096834
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.26345203
78UTX_26944678_Chip-Seq_JUKART_Human1.26045128
79SCL_19346495_ChIP-Seq_HPC-7_Human1.24739975
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24500716
81FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.24246742
82VDR_21846776_ChIP-Seq_THP-1_Human1.23372351
83P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21870838
84LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21694012
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21487622
86UBF1/2_26484160_Chip-Seq_HMECs_Human1.21456086
87RACK7_27058665_Chip-Seq_MCF-7_Human1.19384520
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18644270
89MAF_26560356_Chip-Seq_TH2_Human1.17766229
90KDM2B_26808549_Chip-Seq_DND41_Human1.17248184
91PPARA_22158963_ChIP-Seq_LIVER_Mouse1.14949590
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14792099
93JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14538564
94CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14453800
95TCF7_22412390_ChIP-Seq_EML_Mouse1.13639454
96SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13313398
97FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.12381213
98SALL4_18804426_ChIP-ChIP_XEN_Mouse1.12350737
99KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12149894
100SOX2_20726797_ChIP-Seq_SW620_Human1.11835665
101SMC1_22415368_ChIP-Seq_MEFs_Mouse1.10719113
102CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10640443
103LXR_22292898_ChIP-Seq_THP-1_Human1.09946926
104SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09766382
105SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09766382
106VDR_24763502_ChIP-Seq_THP-1_Human1.09307029
107STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.08896366
108LXR_22158963_ChIP-Seq_LIVER_Mouse1.08459953
109MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.07644946
110KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07586964
111RXR_22158963_ChIP-Seq_LIVER_Mouse1.07430671
112BRD4_25478319_ChIP-Seq_HGPS_Human1.07383772
113GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06268589
114TFEB_21752829_ChIP-Seq_HELA_Human1.05712469
115MYB_21317192_ChIP-Seq_ERMYB_Mouse1.05451437
116GATA1_19941827_ChIP-Seq_MEL_Mouse1.05312325
117MAF_26560356_Chip-Seq_TH1_Human1.04222727
118KDM2B_26808549_Chip-Seq_JURKAT_Human1.04146997
119* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03293284
120TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02616948
121MYC_22102868_ChIP-Seq_BL_Human1.02430455
122MYB_26560356_Chip-Seq_TH2_Human1.02030960
123TP53_22127205_ChIP-Seq_IMR90_Human1.01399630
124GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00964634
125WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00929430
126GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00481763
127SPI1_23127762_ChIP-Seq_K562_Human0.98116392
128PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97375748
129SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97071838
130NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96936968
131GATA1_19941826_ChIP-Seq_K562_Human0.96349671
132MYB_26560356_Chip-Seq_TH1_Human0.96324684
133TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95784041
134SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.95076172
135PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94554795
136NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94130396
137E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93874061
138SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92430804
139KDM2B_26808549_Chip-Seq_K562_Human0.88806300
140STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86406681
141STAT6_21828071_ChIP-Seq_BEAS2B_Human0.85848779
142STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.85796415
143ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.85384267
144SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.83707997

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system4.35321741
2MP0008438_abnormal_cutaneous_collagen3.81758223
3MP0003279_aneurysm3.18411271
4MP0001879_abnormal_lymphatic_vessel2.95483132
5MP0003705_abnormal_hypodermis_morpholog2.95380228
6MP0006054_spinal_hemorrhage2.94251514
7MP0004272_abnormal_basement_membrane2.55610275
8MP0003724_increased_susceptibility_to2.47808133
9MP0005451_abnormal_body_composition2.46583182
10MP0003300_gastrointestinal_ulcer2.38161591
11MP0001958_emphysema2.35184479
12MP0005025_abnormal_response_to2.22618220
13MP0003303_peritoneal_inflammation2.19097832
14MP0005058_abnormal_lysosome_morphology2.16295291
15MP0003091_abnormal_cell_migration2.15159958
16MP0002139_abnormal_hepatobiliary_system2.07761679
17MP0000767_abnormal_smooth_muscle2.07584919
18MP0001915_intracranial_hemorrhage2.03326648
19MP0009384_cardiac_valve_regurgitation2.03254665
20MP0001835_abnormal_antigen_presentation2.00443028
21MP0006082_CNS_inflammation1.99537784
22MP0002254_reproductive_system_inflammat1.95657401
23MP0003566_abnormal_cell_adhesion1.86448611
24MP0000604_amyloidosis1.85740103
25MP0004510_myositis1.84300325
26MP0002138_abnormal_hepatobiliary_system1.83134307
27MP0004947_skin_inflammation1.81205107
28MP0008004_abnormal_stomach_pH1.81201016
29MP0001853_heart_inflammation1.72544402
30MP0009278_abnormal_bone_marrow1.64217828
31MP0002420_abnormal_adaptive_immunity1.61288335
32MP0001819_abnormal_immune_cell1.60795243
33MP0001845_abnormal_inflammatory_respons1.60388869
34MP0000343_altered_response_to1.58593763
35MP0005670_abnormal_white_adipose1.50429711
36MP0005275_abnormal_skin_tensile1.49134933
37MP0005167_abnormal_blood-brain_barrier1.46740809
38MP0008260_abnormal_autophagy1.45783991
39MP0003191_abnormal_cellular_cholesterol1.45088328
40MP0010155_abnormal_intestine_physiology1.44224441
41MP0002405_respiratory_system_inflammati1.42005004
42MP0000685_abnormal_immune_system1.40462533
43MP0005166_decreased_susceptibility_to1.37918199
44MP0005623_abnormal_meninges_morphology1.36632084
45MP0000733_abnormal_muscle_development1.31953047
46MP0009840_abnormal_foam_cell1.31745343
47MP0005023_abnormal_wound_healing1.29445253
48MP0004858_abnormal_nervous_system1.29153995
49MP0009333_abnormal_splenocyte_physiolog1.27956745
50MP0001545_abnormal_hematopoietic_system1.27734351
51MP0005397_hematopoietic_system_phenotyp1.27734351
52MP0002295_abnormal_pulmonary_circulatio1.26135974
53MP0002332_abnormal_exercise_endurance1.23106406
54MP0005257_abnormal_intraocular_pressure1.22220509
55MP0001533_abnormal_skeleton_physiology1.22197225
56MP0002148_abnormal_hypersensitivity_rea1.22168750
57MP0002419_abnormal_innate_immunity1.20712445
58MP0003075_altered_response_to1.20639491
59MP0005310_abnormal_salivary_gland1.19324582
60MP0008007_abnormal_cellular_replicative1.18408748
61MP0004883_abnormal_blood_vessel1.17773176
62MP0000013_abnormal_adipose_tissue1.17340352
63MP0000716_abnormal_immune_system1.15329636
64MP0005164_abnormal_response_to1.15034817
65MP0004084_abnormal_cardiac_muscle1.13696042
66MP0001614_abnormal_blood_vessel1.12820587
67MP0005508_abnormal_skeleton_morphology1.12613909
68MP0003448_altered_tumor_morphology1.12025173
69MP0010352_gastrointestinal_tract_polyps1.11334126
70MP0000249_abnormal_blood_vessel1.09107411
71MP0005076_abnormal_cell_differentiation1.08660626
72MP0003045_fibrosis1.08061359
73MP0001851_eye_inflammation1.06889127
74MP0002925_abnormal_cardiovascular_devel1.03250678
75MP0003806_abnormal_nucleotide_metabolis1.02255690
76MP0003172_abnormal_lysosome_physiology1.02193747
77MP0002877_abnormal_melanocyte_morpholog1.01880846
78MP0005165_increased_susceptibility_to1.01498167
79MP0002128_abnormal_blood_circulation1.01456189
80MP0003385_abnormal_body_wall1.01169735
81MP0005390_skeleton_phenotype0.98845250
82MP0002452_abnormal_antigen_presenting0.98588574
83MP0003436_decreased_susceptibility_to0.98134127
84MP0002998_abnormal_bone_remodeling0.96452022
85MP0009763_increased_sensitivity_to0.95896746
86MP0002932_abnormal_joint_morphology0.94610566
87MP0003656_abnormal_erythrocyte_physiolo0.94015806
88MP0005503_abnormal_tendon_morphology0.93723776
89MP0002398_abnormal_bone_marrow0.93615212
90MP0000163_abnormal_cartilage_morphology0.92797412
91MP0006138_congestive_heart_failure0.92740312
92MP0000858_altered_metastatic_potential0.92573973
93MP0002089_abnormal_postnatal_growth/wei0.92045426
94MP0004808_abnormal_hematopoietic_stem0.91873559
95MP0002933_joint_inflammation0.91740101
96MP0005595_abnormal_vascular_smooth0.90216865
97MP0003329_amyloid_beta_deposits0.89759674
98MP0002429_abnormal_blood_cell0.88812743
99MP0001790_abnormal_immune_system0.86070626
100MP0005387_immune_system_phenotype0.86070626
101MP0003453_abnormal_keratinocyte_physiol0.85774326
102MP0008874_decreased_physiological_sensi0.84930166
103MP0000689_abnormal_spleen_morphology0.84075966
104MP0005000_abnormal_immune_tolerance0.81997742
105MP0003828_pulmonary_edema0.81584417
106MP0000920_abnormal_myelination0.81449814
107MP0001663_abnormal_digestive_system0.79840208
108MP0002113_abnormal_skeleton_development0.79381568
109MP0001542_abnormal_bone_strength0.78977874
110MP0002115_abnormal_skeleton_extremities0.78802824
111MP0002653_abnormal_ependyma_morphology0.78632495
112MP0008469_abnormal_protein_level0.78574714
113MP0002136_abnormal_kidney_physiology0.77510531
114MP0002722_abnormal_immune_system0.76993153
115MP0009785_altered_susceptibility_to0.76921107
116MP0009765_abnormal_xenobiotic_induced0.76284009
117MP0005464_abnormal_platelet_physiology0.76011748
118MP0005360_urolithiasis0.75283316
119MP0001849_ear_inflammation0.74256711
120MP0009764_decreased_sensitivity_to0.74182533
121MP0005197_abnormal_uvea_morphology0.73979106
122MP0010030_abnormal_orbit_morphology0.73950078
123MP0004185_abnormal_adipocyte_glucose0.73402002
124MP0002277_abnormal_respiratory_mucosa0.72192341
125MP0001873_stomach_inflammation0.72106194
126MP0002135_abnormal_kidney_morphology0.71946682
127MP0001800_abnormal_humoral_immune0.71904705
128MP0003795_abnormal_bone_structure0.71831713
129MP0003690_abnormal_glial_cell0.71656740
130MP0005671_abnormal_response_to0.71495914
131MP0002723_abnormal_immune_serum0.69691774
132MP0003221_abnormal_cardiomyocyte_apopto0.69540700
133MP0005666_abnormal_adipose_tissue0.69535107
134MP0000465_gastrointestinal_hemorrhage0.69183596
135MP0003763_abnormal_thymus_physiology0.64749572
136MP0003195_calcinosis0.63783856
137MP0000750_abnormal_muscle_regeneration0.63396670
138MP0005319_abnormal_enzyme/_coenzyme0.57295756
139MP0003634_abnormal_glial_cell0.57155929
140MP0005647_abnormal_sex_gland0.53773705

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.04380989
2Arterial tortuosity (HP:0005116)5.02391512
3Vascular tortuosity (HP:0004948)4.89760691
4Abnormality of macrophages (HP:0004311)4.87144456
5Systemic lupus erythematosus (HP:0002725)4.83307224
6Increased cerebral lipofuscin (HP:0011813)4.46318942
7Premature rupture of membranes (HP:0001788)4.43049908
8Optic neuritis (HP:0100653)4.32982179
9Retrobulbar optic neuritis (HP:0100654)4.32982179
10Cerebral aneurysm (HP:0004944)4.28219218
11Loss of speech (HP:0002371)4.25112104
12Cervical subluxation (HP:0003308)4.08024798
13Aortic aneurysm (HP:0004942)4.05608897
14Myositis (HP:0100614)3.98284254
15Recurrent abscess formation (HP:0002722)3.97529739
16Mediastinal lymphadenopathy (HP:0100721)3.95388765
17Aortic dissection (HP:0002647)3.88095612
18Disinhibition (HP:0000734)3.81002959
19Hematochezia (HP:0002573)3.76712914
20Stomatitis (HP:0010280)3.70972578
21Peritonitis (HP:0002586)3.66988522
22Recurrent gram-negative bacterial infections (HP:0005420)3.52033423
23Nuclear cataract (HP:0100018)3.46595079
24Nonimmune hydrops fetalis (HP:0001790)3.45693944
25Increased neuronal autofluorescent lipopigment (HP:0002074)3.43496233
26Neurofibrillary tangles (HP:0002185)3.35301653
27Abnormality of liposaccharide metabolism (HP:0010968)3.15201973
28Abnormality of glycosphingolipid metabolism (HP:0004343)3.15201973
29Abnormality of glycolipid metabolism (HP:0010969)3.15201973
30Glomerulonephritis (HP:0000099)3.10772972
31Shallow orbits (HP:0000586)3.07956482
32Mutism (HP:0002300)3.04179013
33Spondylolisthesis (HP:0003302)2.99835002
34Axonal loss (HP:0003447)2.98194019
35Keratoconjunctivitis sicca (HP:0001097)2.87139988
36Cortical dysplasia (HP:0002539)2.86921767
37Dysostosis multiplex (HP:0000943)2.80444283
38Aneurysm (HP:0002617)2.76707249
39Broad metatarsal (HP:0001783)2.76706275
40Soft skin (HP:0000977)2.69174481
41Amyloidosis (HP:0011034)2.67767207
42Polycythemia (HP:0001901)2.64160596
43Progressive neurologic deterioration (HP:0002344)2.63435371
44Dilatation of the ascending aorta (HP:0005111)2.62444611
45Apathy (HP:0000741)2.61023328
46Diminished motivation (HP:0000745)2.53589408
47Mitral valve prolapse (HP:0001634)2.51479581
48Keratoconjunctivitis (HP:0001096)2.50919518
49Increased serum ferritin (HP:0003281)2.48483746
50Pulmonary infiltrates (HP:0002113)2.48197093
51Short hallux (HP:0010109)2.45870120
52Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.44528232
53Complement deficiency (HP:0004431)2.43629264
54Cerebral inclusion bodies (HP:0100314)2.43133097
55Abnormality of the vasculature of the conjunctiva (HP:0008054)2.42732026
56Back pain (HP:0003418)2.41985868
57Purpura (HP:0000979)2.41169876
58Neuronal loss in central nervous system (HP:0002529)2.40977093
59Camptodactyly of toe (HP:0001836)2.39629548
60Vasculitis (HP:0002633)2.39613638
61Spinal muscular atrophy (HP:0007269)2.38620750
62Lymphangioma (HP:0100764)2.38194594
63Chronic obstructive pulmonary disease (HP:0006510)2.37521313
64Obstructive lung disease (HP:0006536)2.37521313
65Blue sclerae (HP:0000592)2.36948522
66Hepatosplenomegaly (HP:0001433)2.35809928
67Vertebral compression fractures (HP:0002953)2.35376154
68Upper motor neuron abnormality (HP:0002127)2.33675125
69Abnormality of the peritoneum (HP:0002585)2.33586224
70Vacuolated lymphocytes (HP:0001922)2.32095894
71Chondrocalcinosis (HP:0000934)2.30700781
72Increased IgM level (HP:0003496)2.27579168
73Bladder diverticulum (HP:0000015)2.27214679
74Striae distensae (HP:0001065)2.26407212
75Venous abnormality (HP:0002624)2.23844946
76Myocardial infarction (HP:0001658)2.21914662
77Mucopolysacchariduria (HP:0008155)2.21667424
78Urinary glycosaminoglycan excretion (HP:0003541)2.21667424
79Abnormality of glycosaminoglycan metabolism (HP:0004371)2.21409596
80Abnormality of mucopolysaccharide metabolism (HP:0011020)2.21409596
81Abnormality of polysaccharide metabolism (HP:0011012)2.21409596
82Esophageal varix (HP:0002040)2.20029789
83Recurrent skin infections (HP:0001581)2.19749682
84Nephritis (HP:0000123)2.19500039
85Gingivitis (HP:0000230)2.15743188
86Aplasia/Hypoplasia of the hallux (HP:0008362)2.15358951
87Hand muscle atrophy (HP:0009130)2.13587440
88Biconcave vertebral bodies (HP:0004586)2.13459078
89Asymmetric septal hypertrophy (HP:0001670)2.12509371
90Polyneuropathy (HP:0001271)2.12375054
91Inappropriate behavior (HP:0000719)2.11904141
92Gangrene (HP:0100758)2.11898016
93Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.11474500
94Agnosia (HP:0010524)2.10318832
95Joint stiffness (HP:0001387)2.10292275
96Parakeratosis (HP:0001036)2.09367910
97Interstitial pulmonary disease (HP:0006530)2.09122095
98Tetraparesis (HP:0002273)2.09071309
99Wormian bones (HP:0002645)2.07206484
100Genu recurvatum (HP:0002816)2.07117313
101Spontaneous hematomas (HP:0007420)2.06430786
102Basal ganglia calcification (HP:0002135)2.05436237
103Abnormality of Sharpey fibers (HP:0100685)2.04884966
104Venous insufficiency (HP:0005293)2.03950689
105Coxa vara (HP:0002812)2.03767378
106T lymphocytopenia (HP:0005403)2.03720402
107Ankle contracture (HP:0006466)2.03688318
108Urticaria (HP:0001025)2.02255330
109Dementia (HP:0000726)2.02241725
110Prolonged neonatal jaundice (HP:0006579)2.01419032
111Autoimmune thrombocytopenia (HP:0001973)2.00972225
112Hemoptysis (HP:0002105)2.00699268
113Pathologic fracture (HP:0002756)2.00537256
114Meningitis (HP:0001287)1.99623211
115Ovoid vertebral bodies (HP:0003300)1.97759139
116Osteolytic defects of the phalanges of the hand (HP:0009771)1.96661804
117Osteolytic defects of the hand bones (HP:0009699)1.96661804
118Coxa valga (HP:0002673)1.96342490
119Gastrointestinal stroma tumor (HP:0100723)1.94904520
120Glomerulopathy (HP:0100820)1.94681494
121Petechiae (HP:0000967)1.93156311
122Abnormality of complement system (HP:0005339)1.92759540
123Disproportionate tall stature (HP:0001519)1.92726394
124Absent toe (HP:0010760)1.92206527
125Peripheral demyelination (HP:0011096)1.91854164
126Flexion contracture of toe (HP:0005830)1.91004362
127Joint contractures involving the joints of the feet (HP:0100492)1.91004362
128Recurrent viral infections (HP:0004429)1.90797313
129Neonatal short-limb short stature (HP:0008921)1.90096313
130Distal upper limb amyotrophy (HP:0007149)1.90008386
131Upper limb amyotrophy (HP:0009129)1.90008386
132Bone pain (HP:0002653)1.88846340
133Anorexia (HP:0002039)1.88098299
134Platyspondyly (HP:0000926)1.87918526
135Abnormality of the acetabulum (HP:0003170)1.87454993
136Eczematoid dermatitis (HP:0000976)1.86949193
137Wrist flexion contracture (HP:0001239)1.86873543
138Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.86407821
139Global brain atrophy (HP:0002283)1.85241160
140Bicuspid aortic valve (HP:0001647)1.84723036
141Abnormality of iron homeostasis (HP:0011031)1.83653702
142Encephalitis (HP:0002383)1.83491534
143Personality changes (HP:0000751)1.82406325
144Abnormality of the odontoid process (HP:0003310)1.81821696
145Recurrent fungal infections (HP:0002841)1.81504733
146Hypoplasia of the odontoid process (HP:0003311)1.81339001
147Arthralgia (HP:0002829)1.79241842
148Cellulitis (HP:0100658)1.78698585
149Short nail (HP:0001799)1.78431519
150Premature loss of primary teeth (HP:0006323)1.77591585
151Acne (HP:0001061)1.77465788
152Episodic fever (HP:0001954)1.76411004
153Abnormality of the pleura (HP:0002103)1.75448316
154Vertigo (HP:0002321)1.74836340
155Polygenic inheritance (HP:0010982)1.74366125
156Abnormality of T cell number (HP:0011839)1.74364437
157Broad ribs (HP:0000885)1.73931153
158Hyperextensible skin (HP:0000974)1.73656161
159Short 4th metacarpal (HP:0010044)1.73238039
160Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.73238039
161Abnormality of the pericardium (HP:0001697)1.72290762
162Elevated erythrocyte sedimentation rate (HP:0003565)1.71880992
163Metaphyseal cupping (HP:0003021)1.71511993
164Pulmonary embolism (HP:0002204)1.71258469
165Severe short stature (HP:0003510)1.70535437
166Abnormality of the ischium (HP:0003174)1.70335493
167Abnormality of the nasal mucosa (HP:0000433)1.70203779
168Hypoplastic ischia (HP:0003175)1.68924036
169Cardiomegaly (HP:0001640)1.68598708
170Arterial thrombosis (HP:0004420)1.66254929
171Recurrent bacterial skin infections (HP:0005406)1.65523655
172Flat acetabular roof (HP:0003180)1.64822121
173Capillary hemangiomas (HP:0005306)1.64561641
174Orchitis (HP:0100796)1.64545266

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR5.66381059
2IRAK35.38014992
3TGFBR24.74533283
4LATS23.85132566
5TIE13.60972882
6TAOK23.56222243
7NME23.21358797
8PRPF4B3.13595034
9ERN13.07983602
10MOS2.88653955
11TRIB32.57908705
12IRAK42.57214535
13LATS12.48269973
14MAP3K32.19863395
15TAOK12.16843242
16RIPK42.06651005
17STK102.03201392
18TYK21.99069678
19ARAF1.95583015
20EEF2K1.86548770
21FGR1.86170082
22TGFBR11.84383767
23PAK41.71550575
24JAK11.64990609
25NEK91.60175164
26ERBB41.55007779
27TTN1.53462782
28STK38L1.52727046
29MAP3K131.48428209
30TBK11.48226854
31PKN21.42322925
32PIM21.41568326
33JAK31.38408928
34CSF1R1.38187700
35IRAK21.36666884
36GRK71.31995361
37PRKD31.31345689
38MAP3K141.26380982
39CDC42BPA1.25752292
40CHUK1.24577305
41BCKDK1.22104379
42PDGFRA1.17747980
43KSR21.16951349
44FGFR41.16947582
45ZAP701.12763066
46CDK81.11200304
47PTK61.05438825
48EPHB11.05309159
49RPS6KA41.05150499
50IKBKB1.04519300
51SIK31.02325782
52MAP3K50.99888307
53BMX0.99298505
54KIT0.98676329
55STK30.96198915
56IRAK10.93452853
57PTK2B0.93393619
58JAK20.90257473
59BRAF0.89766440
60MAPKAPK30.89137575
61MAP3K80.89128173
62DDR20.89010493
63MAP4K10.84975768
64TESK10.84756451
65TESK20.83213493
66MAP3K100.81993922
67LYN0.80970267
68MAP3K60.80245150
69TXK0.75462181
70LRRK20.72182514
71FES0.71666746
72INSRR0.71453401
73DYRK1B0.70821104
74CDK90.69681104
75MAPK150.69669858
76MAP2K30.68876698
77PAK20.67870847
78BLK0.67614837
79SYK0.67381222
80RAF10.67218516
81PTK20.66943247
82RET0.66447398
83DYRK30.65794113
84SCYL20.63084714
85ADRBK20.60246208
86TRPM70.59377948
87SIK10.58867666
88EPHA30.58793200
89DAPK30.58071938
90MARK30.57433769
91FER0.56446141
92CSK0.55270662
93SMG10.53675375
94LCK0.52593806
95ABL20.52517542
96MAP3K110.52456547
97RPS6KC10.52281462
98RPS6KL10.52281462
99MAPK120.49700694
100FGFR30.48825504
101DMPK0.48187969
102MAPK40.46433436
103TYRO30.46432409
104PAK10.45279630
105PDGFRB0.45123808
106IGF1R0.44764949
107BTK0.42463589
108TNK20.42213569
109DAPK20.42018236
110NEK10.41859116
111CAMKK20.41232153
112BMPR20.39349663
113PIM10.38738093
114MATK0.38682307
115PKN10.38098804
116PAK60.38031217
117EPHB20.37681745
118PRKD10.36837713
119MAP3K90.36796824
120RPS6KA60.35827892
121MAPK70.35349951
122PRKAA20.34815516
123MAP2K10.34721754
124RIPK10.34499726
125CDK60.33627117
126CAMK1D0.32581658
127ICK0.32308958
128EGFR0.32148444
129ILK0.31510702
130PRKG20.31244208
131MAPKAPK20.30178198
132PDK20.29748068
133MELK0.28671086
134INSR0.27747189
135PDPK10.26284013
136RPS6KA20.26254579
137PRKCD0.26102318
138MTOR0.26025398
139MAP3K10.25863189
140MARK20.25723854
141MAPK110.24676135
142IKBKE0.24507850
143GSK3A0.24496975
144HCK0.24256257
145HIPK20.23574290
146RPS6KA10.23417689
147PDK10.22352361
148STK160.21497595

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005313.14820968
2Other glycan degradation_Homo sapiens_hsa005112.92971579
3Staphylococcus aureus infection_Homo sapiens_hsa051502.65195388
4Malaria_Homo sapiens_hsa051442.19217498
5Allograft rejection_Homo sapiens_hsa053302.18563126
6Leishmaniasis_Homo sapiens_hsa051402.00428525
7AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.99724620
8Graft-versus-host disease_Homo sapiens_hsa053321.93612679
9* Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.83062341
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.80624398
11Asthma_Homo sapiens_hsa053101.78262447
12Prion diseases_Homo sapiens_hsa050201.76627826
13Lysosome_Homo sapiens_hsa041421.73966600
14Pancreatic cancer_Homo sapiens_hsa052121.68540050
15Focal adhesion_Homo sapiens_hsa045101.66068835
16Shigellosis_Homo sapiens_hsa051311.65509934
17Adherens junction_Homo sapiens_hsa045201.61128889
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.59479863
19Pertussis_Homo sapiens_hsa051331.56978835
20Autoimmune thyroid disease_Homo sapiens_hsa053201.56908572
21Osteoclast differentiation_Homo sapiens_hsa043801.55657037
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.55348024
23Toxoplasmosis_Homo sapiens_hsa051451.55007115
24Chronic myeloid leukemia_Homo sapiens_hsa052201.53151008
25TNF signaling pathway_Homo sapiens_hsa046681.52165722
26Small cell lung cancer_Homo sapiens_hsa052221.50693361
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.50627527
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47525375
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.47162206
30ECM-receptor interaction_Homo sapiens_hsa045121.47022239
31Viral myocarditis_Homo sapiens_hsa054161.45659324
32Type I diabetes mellitus_Homo sapiens_hsa049401.45150645
33Apoptosis_Homo sapiens_hsa042101.33650232
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32847957
35Complement and coagulation cascades_Homo sapiens_hsa046101.31325910
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.31013491
37Antigen processing and presentation_Homo sapiens_hsa046121.28954422
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.27828864
39Proteoglycans in cancer_Homo sapiens_hsa052051.26549116
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.26289820
41MicroRNAs in cancer_Homo sapiens_hsa052061.23090273
42Hematopoietic cell lineage_Homo sapiens_hsa046401.20986565
43Bladder cancer_Homo sapiens_hsa052191.20787700
44Legionellosis_Homo sapiens_hsa051341.19834657
45Notch signaling pathway_Homo sapiens_hsa043301.17677163
46TGF-beta signaling pathway_Homo sapiens_hsa043501.15365925
47African trypanosomiasis_Homo sapiens_hsa051431.12175416
48Hepatitis C_Homo sapiens_hsa051601.09655726
49Tuberculosis_Homo sapiens_hsa051521.07497710
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07054156
51Regulation of actin cytoskeleton_Homo sapiens_hsa048101.06759596
52p53 signaling pathway_Homo sapiens_hsa041151.04382613
53Collecting duct acid secretion_Homo sapiens_hsa049661.03445732
54Influenza A_Homo sapiens_hsa051641.03416950
55Melanoma_Homo sapiens_hsa052181.03082151
56B cell receptor signaling pathway_Homo sapiens_hsa046621.01068773
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.99308127
58Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.99266186
59Salmonella infection_Homo sapiens_hsa051320.94960140
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93085698
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.92751103
62HTLV-I infection_Homo sapiens_hsa051660.91757224
63Measles_Homo sapiens_hsa051620.90233303
64Hepatitis B_Homo sapiens_hsa051610.89565948
65Amoebiasis_Homo sapiens_hsa051460.89049267
66Dilated cardiomyopathy_Homo sapiens_hsa054140.88915656
67Hippo signaling pathway_Homo sapiens_hsa043900.88736230
68Rap1 signaling pathway_Homo sapiens_hsa040150.88334913
69Vibrio cholerae infection_Homo sapiens_hsa051100.85166400
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83757438
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82775696
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81935826
73Chemokine signaling pathway_Homo sapiens_hsa040620.81867798
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80209284
75Colorectal cancer_Homo sapiens_hsa052100.78890060
76PI3K-Akt signaling pathway_Homo sapiens_hsa041510.78368731
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.77260596
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76290812
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76025254
80T cell receptor signaling pathway_Homo sapiens_hsa046600.75964571
81Platelet activation_Homo sapiens_hsa046110.75150475
82Pathways in cancer_Homo sapiens_hsa052000.74974952
83Epstein-Barr virus infection_Homo sapiens_hsa051690.74914594
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74106346
85Rheumatoid arthritis_Homo sapiens_hsa053230.72579492
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71612667
87Phagosome_Homo sapiens_hsa041450.71358366
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.70374961
89Galactose metabolism_Homo sapiens_hsa000520.67545609
90Primary immunodeficiency_Homo sapiens_hsa053400.67169752
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.66645554
92Glioma_Homo sapiens_hsa052140.65501240
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.65461501
94VEGF signaling pathway_Homo sapiens_hsa043700.65386386
95Nitrogen metabolism_Homo sapiens_hsa009100.64690033
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63737628
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63344497
98Sphingolipid metabolism_Homo sapiens_hsa006000.60695415
99Systemic lupus erythematosus_Homo sapiens_hsa053220.60322131
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.60272832
101Prolactin signaling pathway_Homo sapiens_hsa049170.60255062
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60082835
103Renal cell carcinoma_Homo sapiens_hsa052110.59733593
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59554453
105HIF-1 signaling pathway_Homo sapiens_hsa040660.58840950
106PPAR signaling pathway_Homo sapiens_hsa033200.56724092
107Acute myeloid leukemia_Homo sapiens_hsa052210.55554860
108Viral carcinogenesis_Homo sapiens_hsa052030.54735138
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54359061
110Arginine and proline metabolism_Homo sapiens_hsa003300.52939795
111Dorso-ventral axis formation_Homo sapiens_hsa043200.52912116
112Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52479406
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51873588
114Endometrial cancer_Homo sapiens_hsa052130.50168219
115Arginine biosynthesis_Homo sapiens_hsa002200.50134426
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49050809
117One carbon pool by folate_Homo sapiens_hsa006700.48784938
118Ras signaling pathway_Homo sapiens_hsa040140.47761917
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47087360
120Prostate cancer_Homo sapiens_hsa052150.46995339
121Herpes simplex infection_Homo sapiens_hsa051680.46236892
122RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46011729
123Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45827150
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38668041
125Endocytosis_Homo sapiens_hsa041440.35203875
126Type II diabetes mellitus_Homo sapiens_hsa049300.35149803
127MAPK signaling pathway_Homo sapiens_hsa040100.34430722
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.27978908
129Pentose phosphate pathway_Homo sapiens_hsa000300.24502565
130Steroid biosynthesis_Homo sapiens_hsa001000.22498955
131FoxO signaling pathway_Homo sapiens_hsa040680.19312409
132Insulin resistance_Homo sapiens_hsa049310.19206604
133SNARE interactions in vesicular transport_Homo sapiens_hsa041300.18297851

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