CHST8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the sulfotransferase 2 family. It is predominantly expressed in the pituitary gland, and is localized to the golgi membrane. This protein catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. It is responsible for sulfation of GalNAc on luteinizing hormone (LH), which is required for production of the sex hormones. Mice lacking this enzyme, exhibit increased levels of circulating LH, and precocious sexual maturation of both male and female mice. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)7.83704027
2nucleobase catabolic process (GO:0046113)6.21565932
3cerebellar Purkinje cell layer development (GO:0021680)5.97074064
4vocalization behavior (GO:0071625)5.89347645
5neuron cell-cell adhesion (GO:0007158)5.61635733
6neurofilament cytoskeleton organization (GO:0060052)5.53715707
7transmission of nerve impulse (GO:0019226)5.45626341
8positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.94612152
9layer formation in cerebral cortex (GO:0021819)4.79522553
10regulation of short-term neuronal synaptic plasticity (GO:0048172)4.74744584
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.68558824
12neuron recognition (GO:0008038)4.58448681
13neuronal ion channel clustering (GO:0045161)4.56945662
14establishment of mitochondrion localization (GO:0051654)4.40741650
15central nervous system projection neuron axonogenesis (GO:0021952)4.36720285
16cell migration in hindbrain (GO:0021535)4.29280746
17mitochondrion transport along microtubule (GO:0047497)4.00352087
18establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.00352087
19cell communication by electrical coupling (GO:0010644)3.99775283
20circadian sleep/wake cycle process (GO:0022410)3.95328796
21adult walking behavior (GO:0007628)3.90844445
22axonal fasciculation (GO:0007413)3.85886761
23synaptic vesicle maturation (GO:0016188)3.78732351
24regulation of catecholamine metabolic process (GO:0042069)3.75595384
25regulation of dopamine metabolic process (GO:0042053)3.75595384
26mechanosensory behavior (GO:0007638)3.73116109
27behavioral response to nicotine (GO:0035095)3.63717824
28regulation of synaptic vesicle exocytosis (GO:2000300)3.57989196
29generation of neurons (GO:0048699)3.56670996
30serotonin receptor signaling pathway (GO:0007210)3.50345978
31protein localization to synapse (GO:0035418)3.48626479
32dendrite development (GO:0016358)3.48007424
33mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.47853025
34regulation of neuronal synaptic plasticity (GO:0048168)3.46082255
35dendrite morphogenesis (GO:0048813)3.45107941
36neuronal action potential propagation (GO:0019227)3.44204104
37regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.43968525
38synaptic vesicle endocytosis (GO:0048488)3.42742941
39glutamate secretion (GO:0014047)3.42331956
40locomotory exploration behavior (GO:0035641)3.42145074
41substrate-independent telencephalic tangential migration (GO:0021826)3.40047114
42substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.40047114
43negative regulation of microtubule polymerization (GO:0031115)3.39925859
44neuromuscular synaptic transmission (GO:0007274)3.37169162
45regulation of synapse structural plasticity (GO:0051823)3.35824216
46regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.35314428
47positive regulation of catecholamine secretion (GO:0033605)3.32151652
48central nervous system neuron axonogenesis (GO:0021955)3.32112098
49cerebellar Purkinje cell differentiation (GO:0021702)3.31083694
50adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.27680202
51protein polyglutamylation (GO:0018095)3.25546185
52postsynaptic membrane organization (GO:0001941)3.24825250
53striatum development (GO:0021756)3.24060615
54regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.23511419
55regulation of synaptic vesicle transport (GO:1902803)3.22673811
56mesenchymal to epithelial transition (GO:0060231)3.21842350
57ionotropic glutamate receptor signaling pathway (GO:0035235)3.20693167
58axon ensheathment in central nervous system (GO:0032291)3.20508919
59central nervous system myelination (GO:0022010)3.20508919
60synaptic vesicle exocytosis (GO:0016079)3.19680683
61synapse assembly (GO:0007416)3.17895146
62synaptic transmission, cholinergic (GO:0007271)3.17869152
63dopamine biosynthetic process (GO:0042416)3.13527314
64regulation of glutamate receptor signaling pathway (GO:1900449)3.13047274
65negative regulation of synaptic transmission, GABAergic (GO:0032229)3.12706591
66membrane repolarization during action potential (GO:0086011)3.11947183
67positive regulation of mitochondrial fission (GO:0090141)3.10993457
68positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.10962356
69social behavior (GO:0035176)3.09259683
70intraspecies interaction between organisms (GO:0051703)3.09259683
71positive regulation of synapse maturation (GO:0090129)3.08757151
72cranial nerve morphogenesis (GO:0021602)3.08514782
73tooth mineralization (GO:0034505)3.08340257
74axon extension (GO:0048675)3.08051410
75dendritic spine morphogenesis (GO:0060997)3.07252493
76negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.06611045
77olfactory bulb development (GO:0021772)3.01449961
78multicellular organismal signaling (GO:0035637)2.98071798
79negative regulation of transcription regulatory region DNA binding (GO:2000678)2.97596945
80regulation of early endosome to late endosome transport (GO:2000641)2.94660243
81negative regulation of catecholamine secretion (GO:0033604)2.93641035
82gamma-aminobutyric acid signaling pathway (GO:0007214)2.92730332
83exploration behavior (GO:0035640)2.91318865
84response to pheromone (GO:0019236)2.90462421
85membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.88975171
86cochlea development (GO:0090102)2.88859449
87neurotransmitter secretion (GO:0007269)2.87665699
88detection of temperature stimulus involved in sensory perception (GO:0050961)2.86881292
89detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.86881292
90gamma-aminobutyric acid transport (GO:0015812)2.86676037
91synaptic vesicle docking involved in exocytosis (GO:0016081)2.85859694
92adult locomotory behavior (GO:0008344)2.82873378
93positive regulation of synapse assembly (GO:0051965)2.82815703
94adult behavior (GO:0030534)2.81862561
95regulation of synapse assembly (GO:0051963)2.79929242
96sensory perception of pain (GO:0019233)2.79584001
97establishment of nucleus localization (GO:0040023)2.76333090
98axonogenesis (GO:0007409)2.74954463
99spinal cord association neuron differentiation (GO:0021527)2.74854101
100detection of temperature stimulus (GO:0016048)2.74786421
101membrane repolarization (GO:0086009)2.74060813
102negative regulation of axon extension involved in axon guidance (GO:0048843)2.73038885
103regulation of membrane repolarization (GO:0060306)2.72656614
104synapse organization (GO:0050808)2.71277645
105protein neddylation (GO:0045116)2.71167353
106glutamate receptor signaling pathway (GO:0007215)2.71099283
107inner ear receptor cell development (GO:0060119)2.70950054
108positive regulation of gastrulation (GO:2000543)2.69854779
109auditory behavior (GO:0031223)2.68418631
110neurotransmitter-gated ion channel clustering (GO:0072578)2.67944841
111regulation of synapse maturation (GO:0090128)2.66998161
112response to auditory stimulus (GO:0010996)2.66116670
113chaperone-mediated protein transport (GO:0072321)2.65310374
114dendritic spine organization (GO:0097061)2.65291822
115growth hormone secretion (GO:0030252)2.65020857
116circadian behavior (GO:0048512)2.64924262
117regulation of dendrite morphogenesis (GO:0048814)2.64765514
118mesenchymal cell differentiation involved in kidney development (GO:0072161)2.64728274
119mesenchymal cell differentiation involved in renal system development (GO:2001012)2.64728274
120regulation of long-term neuronal synaptic plasticity (GO:0048169)2.64667052
121neuron projection morphogenesis (GO:0048812)2.64243120
122synaptic transmission, glutamatergic (GO:0035249)2.62779320
123peristalsis (GO:0030432)2.60927811
124neuron projection extension (GO:1990138)2.60895247
125innervation (GO:0060384)2.60127152
126ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.59570461
127presynaptic membrane assembly (GO:0097105)2.59060516
128negative regulation of axon guidance (GO:1902668)2.58252403
129regulation of respiratory gaseous exchange (GO:0043576)2.58075215
130presynaptic membrane organization (GO:0097090)2.57717436
131neuron-neuron synaptic transmission (GO:0007270)2.57574386
132regulation of dendrite development (GO:0050773)2.57528084
133prepulse inhibition (GO:0060134)2.57416696
134righting reflex (GO:0060013)2.57383905
135genetic imprinting (GO:0071514)2.56970262
136neural nucleus development (GO:0048857)2.56926568
137regulation of dopamine secretion (GO:0014059)2.56308853
138hippocampus development (GO:0021766)2.55798249
139response to misfolded protein (GO:0051788)2.55622767
140dopamine receptor signaling pathway (GO:0007212)2.54905655
141regulation of synaptic transmission, dopaminergic (GO:0032225)2.54869283
142rhythmic behavior (GO:0007622)2.54532107
143neurotransmitter transport (GO:0006836)2.53960801
144positive regulation of synaptic transmission, GABAergic (GO:0032230)2.53490952
145behavioral defense response (GO:0002209)2.52905175
146behavioral fear response (GO:0001662)2.52905175
147learning (GO:0007612)2.52479141
148positive regulation of exocytosis (GO:0045921)2.52007141
149microtubule bundle formation (GO:0001578)2.51924625
150homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.51889522
151spinal cord development (GO:0021510)2.51122416
152regulation of extent of cell growth (GO:0061387)2.46764916
153regulation of axon extension (GO:0030516)2.45903821
154neuron migration (GO:0001764)2.45722806

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EZH2_22144423_ChIP-Seq_EOC_Human6.17354695
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.32445514
3GBX2_23144817_ChIP-Seq_PC3_Human3.36463738
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12403991
5IGF1R_20145208_ChIP-Seq_DFB_Human3.02845349
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.93732090
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.93263047
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.80219750
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.80219750
10SUZ12_27294783_Chip-Seq_ESCs_Mouse2.73572073
11* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.70525912
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62593648
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.60453040
14TAF15_26573619_Chip-Seq_HEK293_Human2.56470923
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51050629
16* EZH2_27304074_Chip-Seq_ESCs_Mouse2.49941775
17EZH2_27294783_Chip-Seq_ESCs_Mouse2.44331222
18* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38337110
19* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.35626811
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.31177348
21* EED_16625203_ChIP-ChIP_MESCs_Mouse2.28296349
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.27191913
23* REST_21632747_ChIP-Seq_MESCs_Mouse2.26843517
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.24533187
25* RNF2_27304074_Chip-Seq_ESCs_Mouse2.19566271
26DROSHA_22980978_ChIP-Seq_HELA_Human2.04528326
27* REST_18959480_ChIP-ChIP_MESCs_Mouse1.86411964
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84425680
29RARB_27405468_Chip-Seq_BRAIN_Mouse1.82538453
30RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.79323982
31* CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.78184559
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74820569
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.70390376
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.69305878
35* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.67143527
36* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.66495041
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65403677
38* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62190859
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59962121
40RNF2_27304074_Chip-Seq_NSC_Mouse1.51651841
41RING1B_27294783_Chip-Seq_ESCs_Mouse1.50539193
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.49014947
43* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44798128
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44670430
45SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.42902153
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39793450
47GATA1_26923725_Chip-Seq_HPCs_Mouse1.39362033
48RING1B_27294783_Chip-Seq_NPCs_Mouse1.28082623
49TET1_21451524_ChIP-Seq_MESCs_Mouse1.27071935
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26878834
51AR_21572438_ChIP-Seq_LNCaP_Human1.26118215
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24436660
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24224632
54ZNF274_21170338_ChIP-Seq_K562_Hela1.23710526
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23563013
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21901072
57ZFP281_18757296_ChIP-ChIP_E14_Mouse1.21402817
58WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19736406
59SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.18774148
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.18041387
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17380478
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.17301889
63P300_19829295_ChIP-Seq_ESCs_Human1.16924102
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.16427487
65P68_20966046_ChIP-Seq_HELA_Human1.16347016
66* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15414741
67DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13922891
68ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13217032
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12403124
70AR_25329375_ChIP-Seq_VCAP_Human1.12084831
71* AR_19668381_ChIP-Seq_PC3_Human1.11331140
72STAT3_23295773_ChIP-Seq_U87_Human1.10168836
73OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.10140012
74SOX2_21211035_ChIP-Seq_LN229_Gbm1.10108515
75IRF1_19129219_ChIP-ChIP_H3396_Human1.09938094
76LXR_22292898_ChIP-Seq_THP-1_Human1.09548813
77BCAT_22108803_ChIP-Seq_LS180_Human1.08635421
78* SMAD4_21799915_ChIP-Seq_A2780_Human1.08585405
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.07944594
80MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.06935741
81ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04832855
82WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02599862
83NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02451622
84AHR_22903824_ChIP-Seq_MCF-7_Human1.01973137
85SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01924255
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01220177
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01220177
88SMAD4_21741376_ChIP-Seq_HESCs_Human1.01120240
89SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00660412
90VDR_22108803_ChIP-Seq_LS180_Human1.00636916
91TP53_20018659_ChIP-ChIP_R1E_Mouse1.00293410
92* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00219918
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99833343
94OCT4_19829295_ChIP-Seq_ESCs_Human0.99574860
95RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99420515
96ARNT_22903824_ChIP-Seq_MCF-7_Human0.99081072
97CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99056771
98KDM2B_26808549_Chip-Seq_K562_Human0.98344289
99SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96156267
100ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95835296
101SMAD3_21741376_ChIP-Seq_ESCs_Human0.94638107
102* RUNX2_22187159_ChIP-Seq_PCA_Human0.94594048
103STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94487164
104TET1_21490601_ChIP-Seq_MESCs_Mouse0.94399089
105JUN_21703547_ChIP-Seq_K562_Human0.93319134
106CTCF_27219007_Chip-Seq_Bcells_Human0.93053171
107SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92805980
108TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92789848
109ERA_21632823_ChIP-Seq_H3396_Human0.92515931
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91499327
111E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.91320301
112EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90843591
113NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.90611691
114TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90397730
115ZFP281_27345836_Chip-Seq_ESCs_Mouse0.90329350
116CTCF_20526341_ChIP-Seq_ESCs_Human0.90317156
117YY1_22570637_ChIP-Seq_MALME-3M_Human0.89880757
118YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89718966
119* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89559190
120* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88362046
121POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87656649
122TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87594390
123TCF4_23295773_ChIP-Seq_U87_Human0.87291382
124CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87000544
125E2F1_20622854_ChIP-Seq_HELA_Human0.86961558
126PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86846132
127SMC4_20622854_ChIP-Seq_HELA_Human0.86658205
128CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86290137
129VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.85865736
130* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85811968
131NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85745026
132PHF8_20622854_ChIP-Seq_HELA_Human0.85721856
133ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83206095
134EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.81265990
135SA1_27219007_Chip-Seq_Bcells_Human0.79646019
136STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.77202043
137* SMAD4_21741376_ChIP-Seq_ESCs_Human0.75720411
138SOX2_16153702_ChIP-ChIP_HESCs_Human0.74700071
139POU5F1_16153702_ChIP-ChIP_HESCs_Human0.72652392
140POU5F1_16518401_ChIP-PET_MESCs_Mouse0.72482340
141SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.72416367
142FOXP1_21924763_ChIP-Seq_HESCs_Human0.71126991
143TAF2_19829295_ChIP-Seq_ESCs_Human0.70959474
144DPY_21335234_ChIP-Seq_ESCs_Mouse0.70698512
145SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.70081495

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.69064516
2MP0004859_abnormal_synaptic_plasticity4.19851390
3MP0002822_catalepsy3.84451062
4MP0006276_abnormal_autonomic_nervous3.63102350
5MP0004270_analgesia3.43083285
6MP0001501_abnormal_sleep_pattern3.27878210
7MP0003635_abnormal_synaptic_transmissio3.18775939
8MP0003123_paternal_imprinting3.07792444
9MP0009745_abnormal_behavioral_response2.76655526
10MP0002063_abnormal_learning/memory/cond2.75506136
11MP0010386_abnormal_urinary_bladder2.75112449
12MP0001968_abnormal_touch/_nociception2.44559509
13MP0002734_abnormal_mechanical_nocicepti2.39009814
14MP0002064_seizures2.35268546
15MP0002733_abnormal_thermal_nociception2.26656638
16MP0000778_abnormal_nervous_system2.26370688
17MP0005423_abnormal_somatic_nervous2.25079648
18MP0002735_abnormal_chemical_nociception2.23994035
19MP0001486_abnormal_startle_reflex2.22454139
20MP0002572_abnormal_emotion/affect_behav2.20126662
21MP0002272_abnormal_nervous_system2.18609405
22MP0002638_abnormal_pupillary_reflex2.14576190
23MP0001970_abnormal_pain_threshold2.13622364
24* MP0001440_abnormal_grooming_behavior2.11745165
25MP0002184_abnormal_innervation2.04942402
26MP0003122_maternal_imprinting2.01812823
27MP0004742_abnormal_vestibular_system2.00925626
28MP0003329_amyloid_beta_deposits1.98959016
29MP0005645_abnormal_hypothalamus_physiol1.98760444
30MP0004858_abnormal_nervous_system1.85745491
31MP0002736_abnormal_nociception_after1.83796113
32MP0003183_abnormal_peptide_metabolism1.83708240
33MP0002067_abnormal_sensory_capabilities1.81236689
34MP0003890_abnormal_embryonic-extraembry1.75548869
35MP0004885_abnormal_endolymph1.73375970
36MP0000569_abnormal_digit_pigmentation1.72843976
37MP0002653_abnormal_ependyma_morphology1.70595308
38MP0002163_abnormal_gland_morphology1.70129015
39MP0004811_abnormal_neuron_physiology1.67813688
40MP0001502_abnormal_circadian_rhythm1.67064989
41MP0003011_delayed_dark_adaptation1.61859367
42MP0000955_abnormal_spinal_cord1.59460405
43MP0008877_abnormal_DNA_methylation1.59219649
44MP0009046_muscle_twitch1.58452935
45* MP0002557_abnormal_social/conspecific_i1.58179573
46MP0001984_abnormal_olfaction1.55525816
47MP0004233_abnormal_muscle_weight1.53043823
48MP0001529_abnormal_vocalization1.50629795
49MP0002882_abnormal_neuron_morphology1.50437152
50MP0010030_abnormal_orbit_morphology1.41462817
51MP0001905_abnormal_dopamine_level1.41404654
52MP0005499_abnormal_olfactory_system1.37572703
53MP0005394_taste/olfaction_phenotype1.37572703
54MP0001299_abnormal_eye_distance/1.33635304
55MP0000538_abnormal_urinary_bladder1.31730885
56MP0001348_abnormal_lacrimal_gland1.30711780
57MP0004145_abnormal_muscle_electrophysio1.30685594
58MP0002066_abnormal_motor_capabilities/c1.29503540
59MP0003942_abnormal_urinary_system1.28928030
60MP0004142_abnormal_muscle_tone1.26197706
61MP0003646_muscle_fatigue1.25318436
62MP0000920_abnormal_myelination1.23835006
63MP0004133_heterotaxia1.23355050
64* MP0002160_abnormal_reproductive_system1.21909799
65MP0002152_abnormal_brain_morphology1.17853521
66MP0002928_abnormal_bile_duct1.16117784
67MP0008872_abnormal_physiological_respon1.16097609
68MP0000751_myopathy1.14844844
69MP0008961_abnormal_basal_metabolism1.11311210
70MP0003119_abnormal_digestive_system1.08978213
71MP0002102_abnormal_ear_morphology1.08691094
72MP0001177_atelectasis1.08437428
73MP0005083_abnormal_biliary_tract1.05390153
74MP0001986_abnormal_taste_sensitivity1.03268908
75MP0001188_hyperpigmentation1.02933697
76MP0001727_abnormal_embryo_implantation1.02282816
77MP0005646_abnormal_pituitary_gland1.01673133
78MP0001963_abnormal_hearing_physiology1.01563635
79MP0002752_abnormal_somatic_nervous1.01359060
80MP0006292_abnormal_olfactory_placode1.00512273
81MP0004924_abnormal_behavior1.00121089
82MP0005386_behavior/neurological_phenoty1.00121089
83MP0005409_darkened_coat_color0.99981023
84MP0001485_abnormal_pinna_reflex0.99383008
85MP0008569_lethality_at_weaning0.98497394
86MP0002229_neurodegeneration0.96833323
87MP0003861_abnormal_nervous_system0.96779931
88MP0009379_abnormal_foot_pigmentation0.96579824
89MP0003283_abnormal_digestive_organ0.96386486
90MP0002751_abnormal_autonomic_nervous0.94150920
91MP0000049_abnormal_middle_ear0.94020245
92MP0003634_abnormal_glial_cell0.93667278
93MP0005195_abnormal_posterior_eye0.90722930
94MP0005379_endocrine/exocrine_gland_phen0.89123052
95MP0001664_abnormal_digestion0.89082710
96MP0003879_abnormal_hair_cell0.87841598
97MP0005197_abnormal_uvea_morphology0.86281864
98MP0002069_abnormal_eating/drinking_beha0.86084369
99MP0000534_abnormal_ureter_morphology0.85913866
100MP0006072_abnormal_retinal_apoptosis0.85679500
101MP0000026_abnormal_inner_ear0.85629528
102MP0000631_abnormal_neuroendocrine_gland0.84947982
103MP0002909_abnormal_adrenal_gland0.84691183
104MP0000604_amyloidosis0.83524224
105MP0003137_abnormal_impulse_conducting0.83314406
106MP0005623_abnormal_meninges_morphology0.83177282
107MP0000462_abnormal_digestive_system0.82448802
108MP0003121_genomic_imprinting0.81163226
109MP0005551_abnormal_eye_electrophysiolog0.80558626
110MP0004130_abnormal_muscle_cell0.79787791
111MP0002876_abnormal_thyroid_physiology0.78867355
112MP0004085_abnormal_heartbeat0.78024335
113MP0009780_abnormal_chondrocyte_physiolo0.76495994
114MP0002938_white_spotting0.76026487
115MP0003385_abnormal_body_wall0.71485790
116MP0004147_increased_porphyrin_level0.70839353
117MP0003633_abnormal_nervous_system0.70614701
118MP0005670_abnormal_white_adipose0.70167801
119MP0003787_abnormal_imprinting0.68526007
120* MP0005389_reproductive_system_phenotype0.68148347
121MP0009250_abnormal_appendicular_skeleto0.66074093
122MP0003938_abnormal_ear_development0.65658901
123MP0003631_nervous_system_phenotype0.65587847
124MP0003315_abnormal_perineum_morphology0.64803931
125MP0003690_abnormal_glial_cell0.63810022
126MP0005535_abnormal_body_temperature0.63623105
127MP0002081_perinatal_lethality0.63142115
128MP0005187_abnormal_penis_morphology0.63044298
129MP0001293_anophthalmia0.62110710

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.88134924
2Focal motor seizures (HP:0011153)6.59960418
3Febrile seizures (HP:0002373)4.44357074
4Focal seizures (HP:0007359)4.23552212
5Split foot (HP:0001839)3.60307698
6Neoplasm of the heart (HP:0100544)3.57003109
7Epileptic encephalopathy (HP:0200134)3.33645987
8Failure to thrive in infancy (HP:0001531)3.13025960
9Generalized tonic-clonic seizures (HP:0002069)3.12551935
10Supranuclear gaze palsy (HP:0000605)3.09896867
11Agitation (HP:0000713)3.07485435
12Atonic seizures (HP:0010819)3.07307323
13Hepatoblastoma (HP:0002884)3.05999061
14Polyphagia (HP:0002591)3.03087884
15Abnormal pancreas size (HP:0012094)2.96533535
16Hypoplasia of the brainstem (HP:0002365)2.94228215
17Aplasia/Hypoplasia of the brainstem (HP:0007362)2.94228215
18Spastic tetraparesis (HP:0001285)2.93079907
19Ankle clonus (HP:0011448)2.92402875
20Anomalous pulmonary venous return (HP:0010772)2.84953241
21Limb dystonia (HP:0002451)2.80389999
22Sleep apnea (HP:0010535)2.80091209
23Hemiparesis (HP:0001269)2.77105110
24Excessive salivation (HP:0003781)2.76841927
25Drooling (HP:0002307)2.76841927
26Abnormality of the lower motor neuron (HP:0002366)2.75477867
27Abnormal social behavior (HP:0012433)2.74927234
28Impaired social interactions (HP:0000735)2.74927234
29Abnormal eating behavior (HP:0100738)2.73814701
30Congenital malformation of the right heart (HP:0011723)2.73795121
31Double outlet right ventricle (HP:0001719)2.73795121
32Rib fusion (HP:0000902)2.65701200
33Esotropia (HP:0000565)2.63583160
34Pheochromocytoma (HP:0002666)2.57374426
35Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.55473555
36Abnormality of alanine metabolism (HP:0010916)2.55473555
37Hyperalaninemia (HP:0003348)2.55473555
38Visual hallucinations (HP:0002367)2.53309439
39Oligodactyly (hands) (HP:0001180)2.53062551
40Abnormality of the aortic arch (HP:0012303)2.52244658
41Partial agenesis of the corpus callosum (HP:0001338)2.46556158
42Abnormality of the corticospinal tract (HP:0002492)2.44730932
43Hyperthyroidism (HP:0000836)2.41176640
44Neoplasm of the adrenal cortex (HP:0100641)2.38551343
45Nephronophthisis (HP:0000090)2.37765013
46Akinesia (HP:0002304)2.37694825
47Abnormality of the pulmonary veins (HP:0011718)2.34488437
48Action tremor (HP:0002345)2.33711212
49Abnormality of midbrain morphology (HP:0002418)2.32299339
50Molar tooth sign on MRI (HP:0002419)2.32299339
51Progressive cerebellar ataxia (HP:0002073)2.32249471
52Type II lissencephaly (HP:0007260)2.32195472
53Spastic gait (HP:0002064)2.26163294
54Dysmetria (HP:0001310)2.25716454
55Bilateral microphthalmos (HP:0007633)2.25533629
56Anterior segment dysgenesis (HP:0007700)2.25405194
57Thoracic kyphosis (HP:0002942)2.24338016
58Anteriorly placed anus (HP:0001545)2.23690900
59Peripheral hypomyelination (HP:0007182)2.23569116
60Deep palmar crease (HP:0006191)2.23402079
61Neonatal hypoglycemia (HP:0001998)2.21508762
62Mixed hearing impairment (HP:0000410)2.21307898
63Retinal dysplasia (HP:0007973)2.20514040
64Fibular aplasia (HP:0002990)2.20394761
65Optic nerve coloboma (HP:0000588)2.19525558
66Chronic hepatic failure (HP:0100626)2.18294961
67Lissencephaly (HP:0001339)2.17982708
68Depression (HP:0000716)2.17911576
69Amyotrophic lateral sclerosis (HP:0007354)2.17372910
70Hypomagnesemia (HP:0002917)2.17357844
71Hypogonadotrophic hypogonadism (HP:0000044)2.16677097
72Absence seizures (HP:0002121)2.14034006
73Anal stenosis (HP:0002025)2.13895740
74Cortical dysplasia (HP:0002539)2.13728876
75Dialeptic seizures (HP:0011146)2.12818656
76Abnormal hair whorl (HP:0010721)2.12570436
77Bony spicule pigmentary retinopathy (HP:0007737)2.12299235
78Chorioretinal atrophy (HP:0000533)2.10514803
79Shawl scrotum (HP:0000049)2.07304882
80Broad-based gait (HP:0002136)2.07108742
81Neuroendocrine neoplasm (HP:0100634)2.05028625
82Abnormality of the labia minora (HP:0012880)2.04974450
83Neurofibrillary tangles (HP:0002185)2.04935224
84Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.03666091
85Degeneration of the lateral corticospinal tracts (HP:0002314)2.03666091
86Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.02473662
87Abnormality of magnesium homeostasis (HP:0004921)2.02268376
88Amblyopia (HP:0000646)2.01830822
89Torticollis (HP:0000473)2.01240568
90Morphological abnormality of the pyramidal tract (HP:0002062)2.00878923
91Megalencephaly (HP:0001355)2.00450827
92Aplasia involving bones of the upper limbs (HP:0009823)1.99974711
93Aplasia of the phalanges of the hand (HP:0009802)1.99974711
94Aplasia involving bones of the extremities (HP:0009825)1.99974711
95Sclerocornea (HP:0000647)1.99477398
96Exotropia (HP:0000577)1.99230929
97Poor suck (HP:0002033)1.99088928
98Unilateral renal agenesis (HP:0000122)1.99084346
99Hypercalciuria (HP:0002150)1.98604192
100Dysdiadochokinesis (HP:0002075)1.97256703
101Asymmetry of the thorax (HP:0001555)1.96543010
102Abnormality of salivation (HP:0100755)1.96309032
103Birth length less than 3rd percentile (HP:0003561)1.95039485
104Oligodactyly (HP:0012165)1.93987359
105Termporal pattern (HP:0011008)1.93691413
106Insidious onset (HP:0003587)1.93691413
107Truncus arteriosus (HP:0001660)1.93631661
108Status epilepticus (HP:0002133)1.93324454
109Impaired vibration sensation in the lower limbs (HP:0002166)1.92892600
110Spinal canal stenosis (HP:0003416)1.92341086
111Spastic tetraplegia (HP:0002510)1.91796318
112Diastasis recti (HP:0001540)1.91616708
113Gait imbalance (HP:0002141)1.91452740
114Microvesicular hepatic steatosis (HP:0001414)1.90566340
115Growth hormone deficiency (HP:0000824)1.90275397
116Polymicrogyria (HP:0002126)1.89953628
117Hypoplastic nipples (HP:0002557)1.89852624
118Specific learning disability (HP:0001328)1.89608243
119Anxiety (HP:0000739)1.89264375
120Anosmia (HP:0000458)1.85514315
121Truncal ataxia (HP:0002078)1.85482615
122Inability to walk (HP:0002540)1.85470463
123Progressive neurologic deterioration (HP:0002344)1.84797340
124Lower limb muscle weakness (HP:0007340)1.84732974
125Abnormality of cells of the erythroid lineage (HP:0012130)1.84603189
126Omphalocele (HP:0001539)1.83919278
127Elfin facies (HP:0004428)1.83675150
128Hypoventilation (HP:0002791)1.83618748
129Aqueductal stenosis (HP:0002410)1.82795287
130Epileptiform EEG discharges (HP:0011182)1.82780185
131Abnormality of the costochondral junction (HP:0000919)1.82748624
132Pancreatic fibrosis (HP:0100732)1.82736905
133EEG with generalized epileptiform discharges (HP:0011198)1.82655607
134Insomnia (HP:0100785)1.81748421
135Narrow nasal bridge (HP:0000446)1.81431206
136Hypsarrhythmia (HP:0002521)1.81143353
137Reticulocytopenia (HP:0001896)1.79410505
138Horseshoe kidney (HP:0000085)1.78728844
139Labial hypoplasia (HP:0000066)1.78191669
140Concave nail (HP:0001598)1.76758374
141Urinary urgency (HP:0000012)1.76509782
142Fetal akinesia sequence (HP:0001989)1.76445777
143Congenital glaucoma (HP:0001087)1.76249200
144Cerebral inclusion bodies (HP:0100314)1.76202285
145Hypoplasia of the corpus callosum (HP:0002079)1.76049914
146Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.75940882
147Focal dystonia (HP:0004373)1.75156980
148Turricephaly (HP:0000262)1.74759904
149Anencephaly (HP:0002323)1.74748796
150Abnormal respiratory motile cilium morphology (HP:0005938)1.74677869
151Abnormal respiratory epithelium morphology (HP:0012253)1.74677869
152Abnormality of the renal medulla (HP:0100957)1.74407649
153Pendular nystagmus (HP:0012043)1.74070702
154Pachygyria (HP:0001302)1.73506207
155Urinary bladder sphincter dysfunction (HP:0002839)1.71899723
156Hyperglycinemia (HP:0002154)1.71218872
157Metaphyseal dysplasia (HP:0100255)1.70170114
158CNS hypomyelination (HP:0003429)1.70150339
159Oligomenorrhea (HP:0000876)1.69969891
160Renovascular hypertension (HP:0100817)1.67636053
161Constricted visual fields (HP:0001133)1.65537608

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK36.78707287
2BCR3.78846348
3SIK23.01451245
4MAP3K92.99818208
5MINK12.82675724
6MARK12.75280456
7NTRK22.64948092
8IRAK22.41209141
9UHMK12.31787967
10NTRK32.22949220
11KSR12.20366575
12FGFR22.14958242
13PNCK2.10019912
14MAP3K42.08146187
15IRAK11.86529455
16CAMKK11.85066754
17DYRK21.69683985
18MAP3K111.68625662
19CASK1.68326070
20EPHA41.58974122
21DYRK31.57524772
22MAP3K121.48501466
23TAF11.47282306
24PAK61.47251251
25BMPR1B1.44382421
26STK111.43033811
27RPS6KA21.42417337
28MAP2K71.39914963
29DYRK1B1.38181487
30ICK1.35086648
31NTRK11.33185464
32TYRO31.32710245
33STK391.31394333
34LIMK11.30681864
35CAMK1D1.30071367
36IRAK41.26600494
37CDK51.26004270
38OXSR11.25684539
39MAPK131.20401382
40TNIK1.18490853
41PAK31.15333929
42MAP2K41.14250230
43PHKG21.07775837
44PHKG11.07775837
45ADRBK21.03093605
46DDR20.98830004
47AURKA0.98651751
48CDK190.94019488
49CAMK1G0.93111258
50CAMK2B0.92867295
51CAMK40.92546732
52PRKCG0.92103687
53KSR20.88722440
54EEF2K0.85086016
55GRK50.84781118
56CDK180.83469333
57SGK20.82766314
58PRKD30.80887731
59SIK10.79510971
60DAPK30.79057961
61ERBB20.77032254
62PRKCI0.76314832
63CAMK2A0.76047782
64DAPK20.75806257
65ABL20.75097901
66EPHB20.75076768
67ILK0.70506064
68PRKAA10.69199745
69ZAP700.68503575
70SGK4940.66286016
71SGK2230.66286016
72FER0.66184188
73SGK30.65932009
74DAPK10.65699130
75BLK0.65386609
76CDK140.64447134
77NME10.64090883
78RPS6KA60.63822874
79MAPK150.63401931
80PRKCE0.61359448
81WNK30.61333096
82PRPF4B0.59331061
83WNK40.58900340
84FYN0.57828697
85CSNK1G10.57141037
86RET0.57129949
87BCKDK0.56438480
88RPS6KC10.56271274
89RPS6KL10.56271274
90CDK150.56044514
91CAMK2D0.55319041
92PRKCZ0.55303722
93ADRBK10.54743629
94TRIM280.54457108
95WNK10.53827185
96MARK20.53524508
97LATS20.52421305
98CSNK1G20.51654743
99CSNK1G30.51584730
100STK380.51570167
101PKN10.49578454
102ROCK20.49491681
103INSRR0.49154007
104CSNK1A1L0.48989845
105CSNK1A10.48487504
106PRKACA0.48014515
107DYRK1A0.47722393
108CAMK2G0.47137497
109FGFR40.47098688
110PINK10.46882043
111ARAF0.46363167
112MAPK120.45360655
113CDK11A0.44466917
114PRKCH0.44211158
115TNK20.42963577
116FES0.42201767
117RIPK40.41579845
118CSNK1E0.41384271
119CHEK20.39700269
120TLK10.39681769
121MAP3K130.39666371
122SGK10.38232024
123PDGFRA0.38099890
124CAMK10.37191134
125PRKCA0.36878240
126RPS6KA10.36769380
127PRKCD0.36714009
128PLK20.36306028
129TRIB30.35221833
130BRAF0.34486444
131LMTK20.34404738
132SRC0.33650546
133CSNK1D0.33616407
134MAPKAPK50.32995716
135MAPK80.32819914
136CDK60.32544651
137PTK20.31903898
138MAP3K10.30664999
139RPS6KA30.29854702
140CAMKK20.27998402

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.37576157
2Synaptic vesicle cycle_Homo sapiens_hsa047212.77195919
3Dopaminergic synapse_Homo sapiens_hsa047282.16181047
4GABAergic synapse_Homo sapiens_hsa047272.14208426
5Sulfur relay system_Homo sapiens_hsa041222.09911449
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.09794055
7Axon guidance_Homo sapiens_hsa043602.07662761
8Glutamatergic synapse_Homo sapiens_hsa047242.03033583
9Cholinergic synapse_Homo sapiens_hsa047252.02358527
10Serotonergic synapse_Homo sapiens_hsa047262.01360020
11Insulin secretion_Homo sapiens_hsa049112.00762673
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.99258533
13Circadian entrainment_Homo sapiens_hsa047131.96937591
14Olfactory transduction_Homo sapiens_hsa047401.95490519
15Morphine addiction_Homo sapiens_hsa050321.87569512
16Long-term potentiation_Homo sapiens_hsa047201.84152920
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.81624221
18Amphetamine addiction_Homo sapiens_hsa050311.78841878
19Taste transduction_Homo sapiens_hsa047421.74777746
20Cocaine addiction_Homo sapiens_hsa050301.71921460
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.64077606
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.61397916
23Long-term depression_Homo sapiens_hsa047301.57349863
24Salivary secretion_Homo sapiens_hsa049701.52803732
25Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.47529374
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.46876038
27Gap junction_Homo sapiens_hsa045401.41869969
28Collecting duct acid secretion_Homo sapiens_hsa049661.39097250
29Huntingtons disease_Homo sapiens_hsa050161.38337101
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34443086
31Gastric acid secretion_Homo sapiens_hsa049711.33511510
32GnRH signaling pathway_Homo sapiens_hsa049121.30285631
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27637415
34Selenocompound metabolism_Homo sapiens_hsa004501.24250477
35Steroid biosynthesis_Homo sapiens_hsa001001.23451468
36Calcium signaling pathway_Homo sapiens_hsa040201.20316776
37Vibrio cholerae infection_Homo sapiens_hsa051101.17675166
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.17486190
39Renin secretion_Homo sapiens_hsa049241.16909906
40cAMP signaling pathway_Homo sapiens_hsa040241.16055883
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15978652
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12477409
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12331024
44ErbB signaling pathway_Homo sapiens_hsa040121.11798642
45Regulation of autophagy_Homo sapiens_hsa041401.11495869
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11172758
47Estrogen signaling pathway_Homo sapiens_hsa049151.08130965
48Melanogenesis_Homo sapiens_hsa049161.07332834
49Type II diabetes mellitus_Homo sapiens_hsa049301.05813819
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04034031
51Oxytocin signaling pathway_Homo sapiens_hsa049211.03113002
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02458704
53Cardiac muscle contraction_Homo sapiens_hsa042600.98074620
54Basal cell carcinoma_Homo sapiens_hsa052170.96120609
55Choline metabolism in cancer_Homo sapiens_hsa052310.95388699
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.95201741
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94318254
58Hedgehog signaling pathway_Homo sapiens_hsa043400.93576935
59Ribosome_Homo sapiens_hsa030100.92758240
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91846912
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.91735010
62Arginine and proline metabolism_Homo sapiens_hsa003300.91686779
63Linoleic acid metabolism_Homo sapiens_hsa005910.91108518
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89538461
65Glioma_Homo sapiens_hsa052140.89035831
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84827327
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84539159
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82737065
69Ras signaling pathway_Homo sapiens_hsa040140.79181687
70Thyroid hormone synthesis_Homo sapiens_hsa049180.78597189
71Hippo signaling pathway_Homo sapiens_hsa043900.78182423
72Phototransduction_Homo sapiens_hsa047440.77522711
73Endocytosis_Homo sapiens_hsa041440.74155920
74Wnt signaling pathway_Homo sapiens_hsa043100.72638811
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70764210
76VEGF signaling pathway_Homo sapiens_hsa043700.70340135
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70115145
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69764783
79Renal cell carcinoma_Homo sapiens_hsa052110.68855134
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.68675598
81Sulfur metabolism_Homo sapiens_hsa009200.67576940
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67355602
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67331146
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66929070
85Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66833798
86MAPK signaling pathway_Homo sapiens_hsa040100.65687536
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65172636
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64177330
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61031463
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59247979
91Nitrogen metabolism_Homo sapiens_hsa009100.58883012
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58363046
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.58302600
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57761919
95Pancreatic secretion_Homo sapiens_hsa049720.57338534
96Ether lipid metabolism_Homo sapiens_hsa005650.57024407
97Phagosome_Homo sapiens_hsa041450.54670362
98Alzheimers disease_Homo sapiens_hsa050100.54476799
99Colorectal cancer_Homo sapiens_hsa052100.54222211
100Dilated cardiomyopathy_Homo sapiens_hsa054140.51987071
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51983886
102Oxidative phosphorylation_Homo sapiens_hsa001900.51557963
103Arginine biosynthesis_Homo sapiens_hsa002200.51397313
104Notch signaling pathway_Homo sapiens_hsa043300.50948985
105Oocyte meiosis_Homo sapiens_hsa041140.50156301
106Rap1 signaling pathway_Homo sapiens_hsa040150.49747594
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49001516
108AMPK signaling pathway_Homo sapiens_hsa041520.48571676
109RNA polymerase_Homo sapiens_hsa030200.47500145
110Fatty acid elongation_Homo sapiens_hsa000620.46542300
111Glucagon signaling pathway_Homo sapiens_hsa049220.46458859
112Alcoholism_Homo sapiens_hsa050340.45650741
113Butanoate metabolism_Homo sapiens_hsa006500.45527344
114Dorso-ventral axis formation_Homo sapiens_hsa043200.45506386
115Fatty acid biosynthesis_Homo sapiens_hsa000610.45362455
116Parkinsons disease_Homo sapiens_hsa050120.44856876
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.44299582
118Insulin signaling pathway_Homo sapiens_hsa049100.44290240
119Inositol phosphate metabolism_Homo sapiens_hsa005620.41944393
120Fat digestion and absorption_Homo sapiens_hsa049750.41391326
121Prion diseases_Homo sapiens_hsa050200.40312512
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40228193
123Cyanoamino acid metabolism_Homo sapiens_hsa004600.39570697
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38764655
125Metabolic pathways_Homo sapiens_hsa011000.35972441
126Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33404681
127Basal transcription factors_Homo sapiens_hsa030220.33196335
128Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32002171
129Peroxisome_Homo sapiens_hsa041460.31980643

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