CHST9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Sulfate groups on carbohydrates confer highly specific functions to glycoproteins, glycolipids, and proteoglycans, and are critical for cell-cell interaction, signal transduction, and embryonic development. Alternatively spliced transcript variants have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)9.00518448
2regulation of cilium movement (GO:0003352)7.34297631
3left/right pattern formation (GO:0060972)6.85114748
4primary alcohol catabolic process (GO:0034310)6.16791480
5left/right axis specification (GO:0070986)6.06522661
6intraciliary transport (GO:0042073)5.68763134
7ethanol metabolic process (GO:0006067)5.48433798
8microtubule bundle formation (GO:0001578)5.41978088
9protein localization to cilium (GO:0061512)5.41257560
10cilium organization (GO:0044782)5.40385484
11vitamin transmembrane transport (GO:0035461)5.28680363
12cilium assembly (GO:0042384)5.25718249
13ventricular system development (GO:0021591)5.08967583
14positive regulation of vesicle fusion (GO:0031340)5.05080720
15neurofilament cytoskeleton organization (GO:0060052)5.03208857
16diterpenoid biosynthetic process (GO:0016102)4.73629854
17cellular potassium ion homeostasis (GO:0030007)4.56897767
18ethanol oxidation (GO:0006069)4.54441182
19protein localization to synapse (GO:0035418)4.38165248
20regulation of microtubule-based movement (GO:0060632)4.36050996
21one-carbon compound transport (GO:0019755)4.26948346
22exogenous drug catabolic process (GO:0042738)4.26700630
23cellular component assembly involved in morphogenesis (GO:0010927)4.21503663
24cilium morphogenesis (GO:0060271)4.18398494
25positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.16224841
26synaptic vesicle endocytosis (GO:0048488)4.10511312
27negative regulation of homotypic cell-cell adhesion (GO:0034111)4.09776906
28regulation of corticosteroid hormone secretion (GO:2000846)4.09555658
29potassium ion homeostasis (GO:0055075)4.09462806
30response to xenobiotic stimulus (GO:0009410)4.08079675
31regulation of type B pancreatic cell apoptotic process (GO:2000674)3.99376055
32pyrimidine-containing compound transmembrane transport (GO:0072531)3.98848125
33endocardial cushion morphogenesis (GO:0003203)3.93227073
34regulation of short-term neuronal synaptic plasticity (GO:0048172)3.90146735
35lung epithelium development (GO:0060428)3.81429362
36urinary tract smooth muscle contraction (GO:0014848)3.77139918
37negative regulation of humoral immune response (GO:0002921)3.76500984
38microtubule-based movement (GO:0007018)3.74597786
39centriole assembly (GO:0098534)3.71311375
40retinoic acid metabolic process (GO:0042573)3.70732806
41regulation of secondary heart field cardioblast proliferation (GO:0003266)3.69891773
42regulation of cardioblast proliferation (GO:0003264)3.69891773
43cell projection assembly (GO:0030031)3.67420639
44establishment of apical/basal cell polarity (GO:0035089)3.66146055
45G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.64570717
46drug catabolic process (GO:0042737)3.61214611
47retinol metabolic process (GO:0042572)3.59286971
48terpenoid biosynthetic process (GO:0016114)3.58778672
49glutamate secretion (GO:0014047)3.53344344
50regulation of vesicle fusion (GO:0031338)3.51766636
51innervation (GO:0060384)3.51589690
52detection of light stimulus involved in visual perception (GO:0050908)3.50776345
53detection of light stimulus involved in sensory perception (GO:0050962)3.50776345
54metanephric mesenchyme development (GO:0072075)3.48354362
55positive regulation of steroid hormone secretion (GO:2000833)3.44477466
56primary alcohol metabolic process (GO:0034308)3.43111236
57negative regulation of T cell differentiation in thymus (GO:0033085)3.41913088
58membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.41571781
59embryonic retina morphogenesis in camera-type eye (GO:0060059)3.36877739
60regulation of glucocorticoid secretion (GO:2000849)3.32934813
61positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.30717308
62glomerular epithelial cell development (GO:0072310)3.30318835
63negative regulation of immunoglobulin mediated immune response (GO:0002890)3.29432338
64negative regulation of B cell mediated immunity (GO:0002713)3.29432338
65pharyngeal system development (GO:0060037)3.29294236
66lateral ventricle development (GO:0021670)3.27304488
67determination of left/right symmetry (GO:0007368)3.25709480
68establishment of monopolar cell polarity (GO:0061162)3.25071536
69establishment or maintenance of monopolar cell polarity (GO:0061339)3.25071536
70glutathione derivative biosynthetic process (GO:1901687)3.22852569
71glutathione derivative metabolic process (GO:1901685)3.22852569
72synaptic vesicle maturation (GO:0016188)3.22818251
73potassium ion export (GO:0071435)3.22553882
74neuromuscular process controlling posture (GO:0050884)3.21723539
75membrane repolarization during action potential (GO:0086011)3.17408695
76nucleoside diphosphate phosphorylation (GO:0006165)3.16428361
77aldehyde catabolic process (GO:0046185)3.16277311
78determination of bilateral symmetry (GO:0009855)3.12459601
79retinal rod cell development (GO:0046548)3.09036656
80regulation of interleukin-5 production (GO:0032674)3.08840453
81regulation of Golgi to plasma membrane protein transport (GO:0042996)3.08001987
82regulation of synaptic vesicle exocytosis (GO:2000300)3.07204805
83sperm capacitation (GO:0048240)3.04660987
84regulation of synaptic vesicle transport (GO:1902803)3.04450524
85specification of symmetry (GO:0009799)3.03378019
86tolerance induction (GO:0002507)3.00899837
87kidney mesenchyme development (GO:0072074)3.00028799
88positive regulation of dendritic spine morphogenesis (GO:0061003)2.98109526
89mesenchyme morphogenesis (GO:0072132)2.96049036
90positive regulation of glycolytic process (GO:0045821)2.95727078
91cytoplasmic microtubule organization (GO:0031122)2.93978639
92positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.93973251
93regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.92884655
94neurotransmitter-gated ion channel clustering (GO:0072578)2.92348942
95L-ascorbic acid metabolic process (GO:0019852)2.91502601
96regulation of steroid hormone secretion (GO:2000831)2.90887714
97phosphatidylcholine biosynthetic process (GO:0006656)2.89756842
98detection of calcium ion (GO:0005513)2.87336850
99calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.85372735
100smoothened signaling pathway (GO:0007224)2.85048768
101regulation of heart rate by cardiac conduction (GO:0086091)2.84308719
102regulation of platelet aggregation (GO:0090330)2.83208387
103cellular ketone body metabolic process (GO:0046950)2.82451269
104negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.81579561
105photoreceptor cell maintenance (GO:0045494)2.81041698
106synaptic vesicle exocytosis (GO:0016079)2.80503049
107O-glycan processing (GO:0016266)2.80434393
108positive regulation of insulin secretion (GO:0032024)2.79829328
109carnitine metabolic process (GO:0009437)2.76010919
110membrane repolarization (GO:0086009)2.74500130
111glandular epithelial cell differentiation (GO:0002067)2.74237180
112glutamate receptor signaling pathway (GO:0007215)2.73090867
113pancreas development (GO:0031016)2.72458573
114glycine transport (GO:0015816)2.69039246
115sperm motility (GO:0030317)2.67628537
116nonmotile primary cilium assembly (GO:0035058)2.67339633
117organic cation transport (GO:0015695)2.66469601
118retinal ganglion cell axon guidance (GO:0031290)2.65731839
119positive regulation of synapse maturation (GO:0090129)2.65701182
120long-term synaptic potentiation (GO:0060291)2.64771858
121regulation of membrane repolarization (GO:0060306)2.64586036
122regulation of neuronal synaptic plasticity (GO:0048168)2.64400826
123amino-acid betaine metabolic process (GO:0006577)2.64392289
124glomerulus development (GO:0032835)2.64366531
125regulation of calcium ion-dependent exocytosis (GO:0017158)2.63841159
126gamma-aminobutyric acid signaling pathway (GO:0007214)2.62331175
127regulation of germinal center formation (GO:0002634)2.62195436
128outflow tract septum morphogenesis (GO:0003148)2.59586734
129excretion (GO:0007588)2.59031656
130regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.58809584
131regulation of female gonad development (GO:2000194)2.57227362
132negative regulation of JUN kinase activity (GO:0043508)2.55835615
133negative regulation of cytosolic calcium ion concentration (GO:0051481)2.55700334
134positive regulation of potassium ion transmembrane transport (GO:1901381)2.55420189
135phosphatidylethanolamine biosynthetic process (GO:0006646)2.54431705
136phosphorelay signal transduction system (GO:0000160)2.54125285
137cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.54092112
138mechanoreceptor differentiation (GO:0042490)2.53750502
139positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.53553949
140benzene-containing compound metabolic process (GO:0042537)2.53217373
141ketone body metabolic process (GO:1902224)2.53173214
142synaptic vesicle docking involved in exocytosis (GO:0016081)2.53161062
143regulation of autophagic vacuole assembly (GO:2000785)2.52992955
144nephron tubule morphogenesis (GO:0072078)2.52436704
145nephron epithelium morphogenesis (GO:0072088)2.52436704
146positive regulation of gastrulation (GO:2000543)2.52137086
147neuron fate specification (GO:0048665)2.51777615
148multicellular organismal water homeostasis (GO:0050891)2.51503498
149negative regulation of calcium ion transmembrane transport (GO:1903170)2.51168532
150negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.51168532
151regulation of interleukin-13 production (GO:0032656)2.50252179
152negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.49424805
153cardiac conduction (GO:0061337)2.49039799
154negative regulation of cation channel activity (GO:2001258)2.48863754
155anterograde axon cargo transport (GO:0008089)2.47957375
156relaxation of cardiac muscle (GO:0055119)2.47614337
157phenylpropanoid metabolic process (GO:0009698)2.47013488
158axon cargo transport (GO:0008088)2.46899740
159endocrine pancreas development (GO:0031018)2.46001941
160positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.45952013
161negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.45303748
162thyroid hormone metabolic process (GO:0042403)2.45075707
163Golgi transport vesicle coating (GO:0048200)2.44454127
164COPI coating of Golgi vesicle (GO:0048205)2.44454127
165axon regeneration (GO:0031103)2.44285457
166positive regulation of synaptic transmission, GABAergic (GO:0032230)2.44042377
167synaptic vesicle transport (GO:0048489)2.43714185
168establishment of synaptic vesicle localization (GO:0097480)2.43714185
169regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.43028820
170synaptic transmission, glutamatergic (GO:0035249)2.42945887
171hydrogen peroxide catabolic process (GO:0042744)2.42242255
172retinal cone cell development (GO:0046549)2.41804723
173protein localization to Golgi apparatus (GO:0034067)2.40181943
174atrial cardiac muscle cell action potential (GO:0086014)2.39924101
175quaternary ammonium group transport (GO:0015697)2.39820934
176cell communication by electrical coupling (GO:0010644)2.39250828
177regulation of bile acid biosynthetic process (GO:0070857)2.39153823
178phosphatidylethanolamine metabolic process (GO:0046337)2.38671668
179amino-acid betaine transport (GO:0015838)2.38253411
180carnitine transport (GO:0015879)2.38253411
181hydrogen peroxide biosynthetic process (GO:0050665)2.37751988
182neurotransmitter biosynthetic process (GO:0042136)2.37328209
183regulation of neuron projection regeneration (GO:0070570)2.37142397
184regulation of axon regeneration (GO:0048679)2.37142397
185negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.35782292
186protein polyglutamylation (GO:0018095)2.34419734
187positive regulation of smoothened signaling pathway (GO:0045880)2.33271136
188water homeostasis (GO:0030104)2.31527349
189carnitine transmembrane transport (GO:1902603)2.31287779
190regulation of vacuole organization (GO:0044088)2.28267320
191positive regulation of protein autophosphorylation (GO:0031954)2.26868398
192axonemal dynein complex assembly (GO:0070286)16.3109980
193cilium or flagellum-dependent cell motility (GO:0001539)14.3610263
194cilium movement (GO:0003341)12.7679796
195epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)11.8423969
196epithelial cilium movement (GO:0003351)10.9613323
197motile cilium assembly (GO:0044458)10.5482011

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.31337807
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.37652047
3EZH2_22144423_ChIP-Seq_EOC_Human3.32666971
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.31687170
5FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.73335099
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.72585602
7* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.60011075
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.44373586
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.41083157
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.40438201
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.25550799
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.20147979
13DROSHA_22980978_ChIP-Seq_HELA_Human2.18453819
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.16584723
15EZH2_27294783_Chip-Seq_ESCs_Mouse2.12387114
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.11522669
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.09287114
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07966777
19* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.06162677
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.05180581
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.04295339
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.04295339
23MTF2_20144788_ChIP-Seq_MESCs_Mouse1.99309965
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.97166789
25* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.95045073
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92225718
27* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91398584
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87426709
29SMAD4_21799915_ChIP-Seq_A2780_Human1.80242601
30PIAS1_25552417_ChIP-Seq_VCAP_Human1.75717425
31FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.75520164
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.75099171
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.72027769
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70402662
35FOXM1_26456572_ChIP-Seq_MCF-7_Human1.66972741
36REST_21632747_ChIP-Seq_MESCs_Mouse1.65668327
37* P300_19829295_ChIP-Seq_ESCs_Human1.64482486
38AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.64216482
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.64121221
40VDR_22108803_ChIP-Seq_LS180_Human1.63790622
41* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.63598402
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.60426651
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59288804
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57320507
45AR_25329375_ChIP-Seq_VCAP_Human1.56988046
46TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.56946141
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54950700
48* SMAD3_21741376_ChIP-Seq_EPCs_Human1.53640007
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.51853711
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51419804
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51176250
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.50700055
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43967461
54* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43762808
55FOXA1_25552417_ChIP-Seq_VCAP_Human1.43203298
56REST_18959480_ChIP-ChIP_MESCs_Mouse1.41653297
57RARB_27405468_Chip-Seq_BRAIN_Mouse1.41374246
58STAT3_23295773_ChIP-Seq_U87_Human1.40854643
59IGF1R_20145208_ChIP-Seq_DFB_Human1.40467062
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.38648943
61AHR_22903824_ChIP-Seq_MCF-7_Human1.37660603
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.37265146
63TCF4_22108803_ChIP-Seq_LS180_Human1.36447015
64PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.34775690
65BCAT_22108803_ChIP-Seq_LS180_Human1.34755320
66P53_22127205_ChIP-Seq_FIBROBLAST_Human1.34466994
67PHF8_20622853_ChIP-Seq_HELA_Human1.34066931
68FOXA1_25329375_ChIP-Seq_VCAP_Human1.33993970
69FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33993970
70ER_23166858_ChIP-Seq_MCF-7_Human1.33894874
71ETV1_20927104_ChIP-Seq_GIST48_Human1.33259033
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30262776
73RNF2_27304074_Chip-Seq_NSC_Mouse1.30088331
74NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30047219
75* TP63_23658742_ChIP-Seq_EP156T_Human1.29463210
76* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27958409
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27472263
78RING1B_27294783_Chip-Seq_ESCs_Mouse1.26452251
79* TP53_18474530_ChIP-ChIP_U2OS_Human1.24807942
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24684251
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.24645186
82HNFA_21074721_ChIP-Seq_CACO-2_Human1.24207153
83EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24184539
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23429359
85EGR1_23403033_ChIP-Seq_LIVER_Mouse1.22888654
86* FUS_26573619_Chip-Seq_HEK293_Human1.22865490
87ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22393453
88CDX2_22108803_ChIP-Seq_LS180_Human1.22372037
89TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.21609462
90* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20087093
91CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.19604093
92* SMAD4_21741376_ChIP-Seq_EPCs_Human1.19430553
93RBPJ_21746931_ChIP-Seq_IB4_Human1.18898510
94SOX2_20726797_ChIP-Seq_SW620_Human1.18361169
95TCF4_23295773_ChIP-Seq_U87_Human1.18149050
96STAT3_18555785_Chip-Seq_ESCs_Mouse1.17478917
97ZNF274_21170338_ChIP-Seq_K562_Hela1.17397075
98* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17390807
99P53_22387025_ChIP-Seq_ESCs_Mouse1.16795404
100LXR_22158963_ChIP-Seq_LIVER_Mouse1.16757933
101GATA4_25053715_ChIP-Seq_YYC3_Human1.15651208
102NFYA_21822215_ChIP-Seq_K562_Human1.14278306
103P300_18555785_Chip-Seq_ESCs_Mouse1.13445123
104NFYB_21822215_ChIP-Seq_K562_Human1.13414571
105EZH2_27294783_Chip-Seq_NPCs_Mouse1.13029530
106EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12909706
107SOX2_18555785_Chip-Seq_ESCs_Mouse1.12710167
108CBX2_22325352_ChIP-Seq_293T-Rex_Human1.12022357
109FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11825174
110EP300_21415370_ChIP-Seq_HL-1_Mouse1.11652976
111TAF15_26573619_Chip-Seq_HEK293_Human1.10965686
112ESR1_21235772_ChIP-Seq_MCF-7_Human1.10117535
113RING1B_27294783_Chip-Seq_NPCs_Mouse1.09677658
114FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.09557666
115* FOXA2_19822575_ChIP-Seq_HepG2_Human1.09150892
116SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09034843
117NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08282080
118TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08276262
119AR_20517297_ChIP-Seq_VCAP_Human1.07994530
120TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07508637
121NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07026515
122NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07026515
123SMRT_27268052_Chip-Seq_Bcells_Human1.06462660
124ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06230142
125IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05915126
126SOX2_21211035_ChIP-Seq_LN229_Gbm1.05834079
127E2F1_18555785_Chip-Seq_ESCs_Mouse1.05234487
128CTCF_18555785_Chip-Seq_ESCs_Mouse1.05069977
129ESR1_20079471_ChIP-ChIP_T-47D_Human1.04481322
130SOX2_19829295_ChIP-Seq_ESCs_Human1.04479974
131NANOG_19829295_ChIP-Seq_ESCs_Human1.04479974
132* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03661974
133* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03550227
134TP53_16413492_ChIP-PET_HCT116_Human1.03057102
135* AR_19668381_ChIP-Seq_PC3_Human1.02321446
136NANOG_18555785_Chip-Seq_ESCs_Mouse1.02065465
137CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00541121
138SMAD4_21741376_ChIP-Seq_HESCs_Human0.99604753
139CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99103917
140* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98195007
141YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97549780
142SMAD3_21741376_ChIP-Seq_HESCs_Human0.97062914
143* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96692768
144RUNX2_22187159_ChIP-Seq_PCA_Human0.96481619
145TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94578271
146OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92429302
147RBPJ_22232070_ChIP-Seq_NCS_Mouse0.91272628
148TBL1_22424771_ChIP-Seq_293T_Human0.90223074
149SMAD3_21741376_ChIP-Seq_ESCs_Human0.88575906
150LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87405460
151EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87150919
152TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87049087
153CBP_20019798_ChIP-Seq_JUKART_Human0.86017351

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.36087478
2MP0002653_abnormal_ependyma_morphology4.02376807
3MP0004133_heterotaxia3.46781220
4MP0002277_abnormal_respiratory_mucosa3.25069248
5MP0004859_abnormal_synaptic_plasticity3.24551518
6MP0002132_abnormal_respiratory_system3.07185908
7MP0003941_abnormal_skin_development2.86267773
8MP0010386_abnormal_urinary_bladder2.81194644
9MP0002139_abnormal_hepatobiliary_system2.71770013
10MP0006292_abnormal_olfactory_placode2.64196518
11MP0001984_abnormal_olfaction2.56657466
12MP0003195_calcinosis2.52586973
13MP0006072_abnormal_retinal_apoptosis2.41975073
14MP0004043_abnormal_pH_regulation2.41967360
15MP0004270_analgesia2.37528970
16MP0005365_abnormal_bile_salt2.31518083
17MP0005551_abnormal_eye_electrophysiolog2.24962914
18MP0000678_abnormal_parathyroid_gland2.21189621
19MP0001502_abnormal_circadian_rhythm2.17342193
20MP0004019_abnormal_vitamin_homeostasis2.14478004
21MP0003283_abnormal_digestive_organ2.08487987
22MP0005394_taste/olfaction_phenotype2.07989331
23MP0005499_abnormal_olfactory_system2.07989331
24MP0003635_abnormal_synaptic_transmissio2.06432290
25MP0002638_abnormal_pupillary_reflex1.93727093
26MP0003183_abnormal_peptide_metabolism1.91605566
27MP0005085_abnormal_gallbladder_physiolo1.89541394
28MP0000013_abnormal_adipose_tissue1.86550350
29MP0010678_abnormal_skin_adnexa1.84656534
30MP0003879_abnormal_hair_cell1.84488661
31MP0008789_abnormal_olfactory_epithelium1.79269407
32MP0000383_abnormal_hair_follicle1.78378557
33MP0002063_abnormal_learning/memory/cond1.74388638
34MP0005253_abnormal_eye_physiology1.73026475
35MP0002735_abnormal_chemical_nociception1.69782607
36MP0002272_abnormal_nervous_system1.67002676
37MP0005646_abnormal_pituitary_gland1.66728851
38MP0002751_abnormal_autonomic_nervous1.66214422
39MP0005084_abnormal_gallbladder_morpholo1.61621336
40MP0002168_other_aberrant_phenotype1.58650743
41MP0009745_abnormal_behavioral_response1.58309109
42MP0002184_abnormal_innervation1.55441187
43MP0005636_abnormal_mineral_homeostasis1.54961256
44MP0002734_abnormal_mechanical_nocicepti1.54448146
45MP0010329_abnormal_lipoprotein_level1.54280669
46MP0002693_abnormal_pancreas_physiology1.54239530
47MP0002160_abnormal_reproductive_system1.52166620
48MP0002909_abnormal_adrenal_gland1.51454916
49MP0001485_abnormal_pinna_reflex1.51432527
50MP0005379_endocrine/exocrine_gland_phen1.50049681
51MP0002138_abnormal_hepatobiliary_system1.49742322
52MP0005423_abnormal_somatic_nervous1.47924447
53MP0002064_seizures1.45448372
54MP0001188_hyperpigmentation1.40760595
55MP0010234_abnormal_vibrissa_follicle1.39072538
56MP0002090_abnormal_vision1.38522987
57MP0006276_abnormal_autonomic_nervous1.38231736
58MP0002928_abnormal_bile_duct1.37202407
59MP0003136_yellow_coat_color1.36747763
60MP0004885_abnormal_endolymph1.35856307
61MP0000778_abnormal_nervous_system1.34487504
62MP0002572_abnormal_emotion/affect_behav1.34271103
63MP0005623_abnormal_meninges_morphology1.33556399
64MP0000955_abnormal_spinal_cord1.33317238
65MP0001501_abnormal_sleep_pattern1.28091470
66MP0004145_abnormal_muscle_electrophysio1.26993913
67MP0009780_abnormal_chondrocyte_physiolo1.26804761
68MP0002822_catalepsy1.23818333
69MP0002557_abnormal_social/conspecific_i1.21387152
70MP0003252_abnormal_bile_duct1.21322582
71MP0010368_abnormal_lymphatic_system1.21094676
72MP0005220_abnormal_exocrine_pancreas1.20359062
73MP0008872_abnormal_physiological_respon1.19949686
74MP0009643_abnormal_urine_homeostasis1.18614244
75MP0000534_abnormal_ureter_morphology1.18605066
76MP0003890_abnormal_embryonic-extraembry1.16297258
77MP0001666_abnormal_nutrient_absorption1.16269825
78MP0002876_abnormal_thyroid_physiology1.15791972
79MP0003656_abnormal_erythrocyte_physiolo1.14393618
80MP0005645_abnormal_hypothalamus_physiol1.14168313
81MP0002882_abnormal_neuron_morphology1.14072557
82MP0003942_abnormal_urinary_system1.13705813
83MP0000566_synostosis1.12305087
84MP0001968_abnormal_touch/_nociception1.11725365
85MP0002067_abnormal_sensory_capabilities1.11705589
86MP0003950_abnormal_plasma_membrane1.11165022
87MP0008260_abnormal_autophagy1.10361498
88MP0001346_abnormal_lacrimal_gland1.09971186
89MP0010030_abnormal_orbit_morphology1.09270441
90MP0001486_abnormal_startle_reflex1.08937518
91MP0000631_abnormal_neuroendocrine_gland1.08768002
92MP0005408_hypopigmentation1.08602402
93MP0001944_abnormal_pancreas_morphology1.08231922
94MP0002163_abnormal_gland_morphology1.07648428
95MP0002078_abnormal_glucose_homeostasis1.07278800
96MP0005395_other_phenotype1.07133602
97MP0002234_abnormal_pharynx_morphology1.06736574
98MP0003878_abnormal_ear_physiology1.04080222
99MP0005377_hearing/vestibular/ear_phenot1.04080222
100MP0004858_abnormal_nervous_system1.04073239
101MP0005332_abnormal_amino_acid1.03793672
102MP0008875_abnormal_xenobiotic_pharmacok1.02423635
103MP0001765_abnormal_ion_homeostasis1.01912928
104MP0005257_abnormal_intraocular_pressure0.99504941
105MP0005389_reproductive_system_phenotype0.98232054
106MP0003122_maternal_imprinting0.97881844
107MP0002752_abnormal_somatic_nervous0.97593205
108MP0005083_abnormal_biliary_tract0.96109460
109MP0008961_abnormal_basal_metabolism0.95940323
110MP0002282_abnormal_trachea_morphology0.92709986
111MP0001963_abnormal_hearing_physiology0.91863660
112MP0005248_abnormal_Harderian_gland0.91658776
113MP0004215_abnormal_myocardial_fiber0.91604903
114MP0003011_delayed_dark_adaptation0.90580698
115MP0002877_abnormal_melanocyte_morpholog0.89875619
116MP0003943_abnormal_hepatobiliary_system0.89586903
117MP0003953_abnormal_hormone_level0.89539566
118MP0001756_abnormal_urination0.88098136
119MP0002733_abnormal_thermal_nociception0.87273867
120MP0002229_neurodegeneration0.86124408
121MP0003329_amyloid_beta_deposits0.85372396
122MP0004811_abnormal_neuron_physiology0.85167660
123MP0009046_muscle_twitch0.84789564
124MP0002118_abnormal_lipid_homeostasis0.83681878
125MP0001970_abnormal_pain_threshold0.83057800
126MP0003938_abnormal_ear_development0.82246305
127MP0008877_abnormal_DNA_methylation0.81966256
128MP0000003_abnormal_adipose_tissue0.81676145
129MP0005195_abnormal_posterior_eye0.81498320
130MP0002233_abnormal_nose_morphology0.81450140
131MP0008569_lethality_at_weaning0.79900594
132MP0004036_abnormal_muscle_relaxation0.79650923
133MP0002837_dystrophic_cardiac_calcinosis0.79362268
134MP0000639_abnormal_adrenal_gland0.78589318
135MP0003172_abnormal_lysosome_physiology0.77729641
136MP0002254_reproductive_system_inflammat0.77223223
137MP0000026_abnormal_inner_ear0.76594334
138MP0003633_abnormal_nervous_system0.76499995
139MP0000751_myopathy0.74743165
140MP0001324_abnormal_eye_pigmentation0.73763462
141MP0005391_vision/eye_phenotype0.73676540
142MP0002938_white_spotting0.72594789
143MP0002136_abnormal_kidney_physiology0.71154883
144MP0005075_abnormal_melanosome_morpholog0.68340349
145MP0001270_distended_abdomen0.65558585
146MP0006036_abnormal_mitochondrial_physio0.64121745
147MP0001986_abnormal_taste_sensitivity0.63833288
148MP0004142_abnormal_muscle_tone0.63000178
149MP0001929_abnormal_gametogenesis0.62955115
150MP0003698_abnormal_male_reproductive0.60576505
151MP0001664_abnormal_digestion0.58376149
152MP0000427_abnormal_hair_cycle0.56828875

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.84417381
2Absent/shortened dynein arms (HP:0200106)9.80877731
3Dynein arm defect of respiratory motile cilia (HP:0012255)9.80877731
4Abnormal ciliary motility (HP:0012262)9.74234859
5Rhinitis (HP:0012384)9.11640981
6Chronic bronchitis (HP:0004469)7.14180210
7Bronchiectasis (HP:0002110)6.75730347
8Nasal polyposis (HP:0100582)5.40959049
9Congenital stationary night blindness (HP:0007642)4.56487031
10Abnormality of the nasal mucosa (HP:0000433)4.33584559
11Increased circulating renin level (HP:0000848)4.33074722
12Pancreatic fibrosis (HP:0100732)3.90270345
13Bronchitis (HP:0012387)3.84193682
14Infertility (HP:0000789)3.82015914
15True hermaphroditism (HP:0010459)3.75621207
16Recurrent sinusitis (HP:0011108)3.73164470
17Occipital encephalocele (HP:0002085)3.59498706
18Chronic sinusitis (HP:0011109)3.48408320
19Pancreatic cysts (HP:0001737)3.46014109
20Hypoglycemic seizures (HP:0002173)3.39955928
21Male infertility (HP:0003251)3.30464167
22Nephronophthisis (HP:0000090)3.20669985
23Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.19978436
24Abnormality of midbrain morphology (HP:0002418)3.17756530
25Molar tooth sign on MRI (HP:0002419)3.17756530
26Recurrent otitis media (HP:0000403)3.13440095
27Cystic liver disease (HP:0006706)3.09512749
28Prolonged QT interval (HP:0001657)3.01956694
29Turricephaly (HP:0000262)2.99872319
30Absence seizures (HP:0002121)2.97789664
31Congenital sensorineural hearing impairment (HP:0008527)2.97643788
32Osteomalacia (HP:0002749)2.93791469
33Aplasia/Hypoplasia of the tibia (HP:0005772)2.93431293
34Syncope (HP:0001279)2.88903314
35Decreased central vision (HP:0007663)2.87860534
36Ventricular fibrillation (HP:0001663)2.84447754
37Absent eyebrow (HP:0002223)2.74322379
38Papillary thyroid carcinoma (HP:0002895)2.72334593
39Hypothermia (HP:0002045)2.69276481
40Focal motor seizures (HP:0011153)2.68698505
41Cutaneous finger syndactyly (HP:0010554)2.67108090
42Retinal atrophy (HP:0001105)2.65633311
43Hyperkalemia (HP:0002153)2.63962209
44Chronic hepatic failure (HP:0100626)2.63715080
45Pheochromocytoma (HP:0002666)2.62531206
46Abnormality of the renal medulla (HP:0100957)2.61848337
47Dialeptic seizures (HP:0011146)2.59040051
48Ketoacidosis (HP:0001993)2.54401968
49Febrile seizures (HP:0002373)2.53497132
50Hyperactive renin-angiotensin system (HP:0000841)2.52805054
51Chronic otitis media (HP:0000389)2.49660336
52Bundle branch block (HP:0011710)2.47165541
53Medial flaring of the eyebrow (HP:0010747)2.46855702
54Abnormality of macular pigmentation (HP:0008002)2.46250756
55Epileptic encephalopathy (HP:0200134)2.46178314
56Abnormality of renin-angiotensin system (HP:0000847)2.44951233
57Postaxial foot polydactyly (HP:0001830)2.43931725
58Symptomatic seizures (HP:0011145)2.43543285
59Hyperinsulinemic hypoglycemia (HP:0000825)2.41264526
60Stomach cancer (HP:0012126)2.37464965
61Myokymia (HP:0002411)2.36416815
62Abnormality of calcium-phosphate metabolism (HP:0100530)2.36042234
63Palpitations (HP:0001962)2.35680652
64Cutaneous syndactyly (HP:0012725)2.33872465
65Epileptiform EEG discharges (HP:0011182)2.32474082
66Hyperglycemia (HP:0003074)2.31195173
67Hypoglycemic coma (HP:0001325)2.30693668
68Abnormal pancreas size (HP:0012094)2.30128543
69Bony spicule pigmentary retinopathy (HP:0007737)2.30058302
70Vaginal atresia (HP:0000148)2.28887931
71Male pseudohermaphroditism (HP:0000037)2.28361704
72Neuroendocrine neoplasm (HP:0100634)2.27627597
73Aplasia/Hypoplasia of the fovea (HP:0008060)2.26853043
74Hypoplasia of the fovea (HP:0007750)2.26853043
75Ulnar claw (HP:0001178)2.26741543
76Severe visual impairment (HP:0001141)2.26314337
77EEG with generalized epileptiform discharges (HP:0011198)2.26021172
78Tubulointerstitial nephritis (HP:0001970)2.25955002
79Congenital hepatic fibrosis (HP:0002612)2.23957642
80Diastasis recti (HP:0001540)2.23382963
81Genital tract atresia (HP:0001827)2.21614533
82Atonic seizures (HP:0010819)2.21358502
83Bifid tongue (HP:0010297)2.20617114
84Short tibia (HP:0005736)2.19232967
85Morphological abnormality of the middle ear (HP:0008609)2.17544559
86Thyroid carcinoma (HP:0002890)2.17123681
87Tubular atrophy (HP:0000092)2.16320757
88Abnormality of the fovea (HP:0000493)2.15734248
89Humeroradial synostosis (HP:0003041)2.15291377
90Synostosis involving the elbow (HP:0003938)2.15291377
91Atelectasis (HP:0100750)2.14739731
92Choanal stenosis (HP:0000452)2.14097103
93Dysautonomia (HP:0002459)2.12445314
94Congenital primary aphakia (HP:0007707)2.12351498
95Gait imbalance (HP:0002141)2.11781970
96Keratoconus (HP:0000563)2.10385544
97Increased corneal curvature (HP:0100692)2.10385544
98Abnormality of chloride homeostasis (HP:0011422)2.10333146
99Supranuclear gaze palsy (HP:0000605)2.09897845
100Generalized tonic-clonic seizures (HP:0002069)2.09795543
101Knee flexion contracture (HP:0006380)2.09605616
102Furrowed tongue (HP:0000221)2.09394805
103Abnormal EKG (HP:0003115)2.05034802
104Labial hypoplasia (HP:0000066)2.04028223
105Gout (HP:0001997)2.03806995
106Myelomeningocele (HP:0002475)2.03442666
107Abnormality of potassium homeostasis (HP:0011042)2.01303720
108Anencephaly (HP:0002323)2.00987483
109Aplasia involving bones of the upper limbs (HP:0009823)2.00516929
110Aplasia of the phalanges of the hand (HP:0009802)2.00516929
111Aplasia involving bones of the extremities (HP:0009825)2.00516929
112Aplasia/Hypoplasia of the tongue (HP:0010295)2.00456988
113Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.0626752
114Abnormal respiratory epithelium morphology (HP:0012253)10.0952986
115Abnormal respiratory motile cilium morphology (HP:0005938)10.0952986
116Polydipsia (HP:0001959)1.99586533
117Abnormal drinking behavior (HP:0030082)1.99586533
118Metabolic alkalosis (HP:0200114)1.96975018
119Nephrogenic diabetes insipidus (HP:0009806)1.94410472
120Abnormality of the lacrimal duct (HP:0011481)1.93959129
121Septo-optic dysplasia (HP:0100842)1.92814741
122Agitation (HP:0000713)1.90719054
123Renal salt wasting (HP:0000127)1.90443402
124Hypomagnesemia (HP:0002917)1.89770184
125Chorioretinal atrophy (HP:0000533)1.88424654
126Enlarged kidneys (HP:0000105)1.87665292
127Abnormal rod and cone electroretinograms (HP:0008323)1.87268582
128Tetany (HP:0001281)1.86099431
129Polyuria (HP:0000103)1.85636263
130Split foot (HP:0001839)1.85612014
131Shawl scrotum (HP:0000049)1.84490105
132Hyperaldosteronism (HP:0000859)1.84239233
133Decreased circulating renin level (HP:0003351)1.83708906
134Lip pit (HP:0100267)1.83358460
135Bicornuate uterus (HP:0000813)1.82041565
136Testicular neoplasm (HP:0010788)1.81499504
137Long toe (HP:0010511)1.81471327
138Sclerocornea (HP:0000647)1.80953908
139Focal seizures (HP:0007359)1.80157669
140Aplasia/Hypoplasia of the spleen (HP:0010451)1.79176969
141Anteriorly placed anus (HP:0001545)1.78207337
142Hypoplastic female external genitalia (HP:0012815)1.77360821
143Abnormality of magnesium homeostasis (HP:0004921)1.77286379
144Progressive cerebellar ataxia (HP:0002073)1.76568122
145Asplenia (HP:0001746)1.75835993
146Postaxial hand polydactyly (HP:0001162)1.75662579
147Late onset (HP:0003584)1.75446374
148Nephropathy (HP:0000112)1.72972499
149Oculomotor apraxia (HP:0000657)1.71049940
150Abnormality of the renal cortex (HP:0011035)1.69258865
151Recurrent bronchitis (HP:0002837)1.57327944
152Median cleft lip (HP:0000161)1.45615345
153Bell-shaped thorax (HP:0001591)1.45439845
154Bile duct proliferation (HP:0001408)1.44342267
155Abnormal biliary tract physiology (HP:0012439)1.44342267
156Hypokalemic alkalosis (HP:0001949)1.41980496
157Tubulointerstitial abnormality (HP:0001969)1.40360461
158Absent rod-and cone-mediated responses on ERG (HP:0007688)1.38237483
159Poor coordination (HP:0002370)1.36535819
160Abnormality of monocarboxylic acid metabolism (HP:0010996)1.36143994
161Vascular calcification (HP:0004934)1.35420432
162Stage 5 chronic kidney disease (HP:0003774)1.33293867
163Abnormality of the pancreatic islet cells (HP:0006476)1.31382968
164Abnormality of endocrine pancreas physiology (HP:0012093)1.31382968
165Preaxial hand polydactyly (HP:0001177)1.31290447
166Bifid scrotum (HP:0000048)1.30121033
167Abnormality of renal excretion (HP:0011036)1.25151890
168Large for gestational age (HP:0001520)1.23531477
169Abnormality of vitamin metabolism (HP:0100508)1.23356387
170Retinitis pigmentosa (HP:0000510)1.22882338
171Abnormality of permanent molar morphology (HP:0011071)1.21123585
172Abnormality of the dental root (HP:0006486)1.21123585
173Taurodontia (HP:0000679)1.21123585
174Disproportionate short-trunk short stature (HP:0003521)1.20772554
175Short thorax (HP:0010306)1.20470950
176Insulin-resistant diabetes mellitus (HP:0000831)1.20257189
177Intestinal atresia (HP:0011100)1.19483640
178Supernumerary spleens (HP:0009799)1.18667208

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK6.67113840
2NTRK36.02875740
3MST45.93878511
4WNK34.45665607
5EPHA22.92899567
6MAPK152.92483190
7WNK42.84124603
8FER2.76841244
9EPHA42.32957561
10FGFR21.99581662
11MAP4K21.96699941
12MAP3K91.96499107
13MINK11.84943818
14FRK1.74479907
15KSR21.73709544
16NME11.73245678
17GRK11.68450068
18MAP2K71.67857591
19IRAK31.66896914
20MAPKAPK31.61323828
21STK241.61279489
22STK381.61158581
23WNK11.58805973
24SIK31.55792713
25PAK31.48744967
26MAP3K21.44979366
27FGFR31.44293959
28STK391.43469877
29SGK4941.34060719
30SGK2231.34060719
31TRPM71.33225891
32INSRR1.31644593
33SGK21.31088827
34PNCK1.26469874
35HIPK21.23789741
36ACVR1B1.22620660
37PRPF4B1.19682217
38MAP2K61.16605334
39LMTK21.15583375
40PTK2B1.12482595
41ERBB31.10256406
42ZAK1.10075555
43STK38L1.09947389
44IRAK21.03768722
45MAPK131.03356624
46STK31.03098242
47TTK1.03023755
48LATS21.00266852
49MAP3K130.99566200
50PAK60.95865482
51MAP3K120.94559991
52NLK0.94397182
53STK160.94047653
54UHMK10.92808152
55CAMK2A0.92674718
56PRKCI0.91132658
57PRKAA20.89060847
58CAMK40.88642066
59FES0.86693712
60PLK20.84869681
61TLK10.84528277
62MARK20.83992229
63MAP3K10.83179309
64CAMK10.82834180
65CAMK2D0.81424903
66MAP3K40.80810609
67SCYL20.79839907
68BRSK20.79470344
69CDC42BPA0.78815226
70NEK60.78216720
71EPHA30.75661575
72DYRK1A0.75270384
73PHKG20.73718757
74PHKG10.73718757
75MARK10.71093269
76PINK10.65406133
77NEK10.64033032
78SIK20.63499174
79PRKCG0.61150883
80PRKD30.60373025
81SGK30.58523135
82MAP2K10.57321982
83LATS10.56813809
84MAP3K30.55563674
85CAMK2B0.54859973
86KSR10.51815176
87ERBB40.51779137
88MKNK20.50784562
89DMPK0.50093555
90SGK10.49961273
91BRAF0.49512672
92STK110.48854050
93PRKACA0.47084329
94CDK50.46479854
95CSNK1G20.46399269
96CSNK1G10.45510259
97CSK0.45308567
98FGFR10.44907843
99EIF2AK30.43992693
100PRKCE0.43906624
101DAPK20.43767442
102PRKCA0.43280655
103BMPR1B0.42169713
104AKT30.41972490
105EEF2K0.41840256
106BCR0.41840017
107IRAK10.41412505
108ARAF0.40898698
109PRKCQ0.40279649
110NEK90.39324857
111ADRBK10.38996684
112OXSR10.38700318
113CAMK2G0.38325081
114ADRBK20.36798145
115CSNK1E0.36703143
116CSNK1A10.36226038
117NTRK10.36216415
118CASK0.35977109
119STK100.35659325
120PTK20.34067756
121MAP3K70.33653318
122PRKDC0.33267694
123EPHB10.32842899
124CDK30.32538486
125TRIM280.32382953
126STK40.32208569
127CAMKK20.32138821
128CAMKK10.29987524
129ROCK10.29894659
130DYRK1B0.29458627
131TSSK60.29443570
132PRKCZ0.28900948
133TAOK20.28751064
134PLK30.28199011
135PRKCH0.27971547
136PLK10.27404515
137ABL10.27296880
138PRKAA10.27104570
139DAPK10.27049485
140ERBB20.25930970
141RPS6KA20.25914881
142PASK0.25431505
143PRKG10.25391986
144LRRK20.23525543
145ATM0.23223926

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.60487851
2Nicotine addiction_Homo sapiens_hsa050333.36780145
3Caffeine metabolism_Homo sapiens_hsa002323.00175055
4Histidine metabolism_Homo sapiens_hsa003402.99831794
5Circadian rhythm_Homo sapiens_hsa047102.90344679
6Synaptic vesicle cycle_Homo sapiens_hsa047212.73894518
7GABAergic synapse_Homo sapiens_hsa047272.66747876
8Insulin secretion_Homo sapiens_hsa049112.66127148
9beta-Alanine metabolism_Homo sapiens_hsa004102.48037509
10Retinol metabolism_Homo sapiens_hsa008302.45011466
11Circadian entrainment_Homo sapiens_hsa047132.42369629
12Tyrosine metabolism_Homo sapiens_hsa003502.37242801
13Amphetamine addiction_Homo sapiens_hsa050312.24972216
14Morphine addiction_Homo sapiens_hsa050322.21121175
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.10998419
16Long-term potentiation_Homo sapiens_hsa047202.03602429
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.03030932
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.94580128
19Glutamatergic synapse_Homo sapiens_hsa047241.84551561
20Glutathione metabolism_Homo sapiens_hsa004801.78954822
21Taste transduction_Homo sapiens_hsa047421.74738604
22Olfactory transduction_Homo sapiens_hsa047401.71293849
23Phototransduction_Homo sapiens_hsa047441.70489954
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.64772528
25Peroxisome_Homo sapiens_hsa041461.61713462
26Serotonergic synapse_Homo sapiens_hsa047261.57634303
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.56056104
28Cholinergic synapse_Homo sapiens_hsa047251.55523706
29Sphingolipid metabolism_Homo sapiens_hsa006001.54038086
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.53390728
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53226701
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49173843
33Dopaminergic synapse_Homo sapiens_hsa047281.45860651
34Cocaine addiction_Homo sapiens_hsa050301.45447166
35Tryptophan metabolism_Homo sapiens_hsa003801.45081675
36Collecting duct acid secretion_Homo sapiens_hsa049661.45015105
37Renin secretion_Homo sapiens_hsa049241.38766348
38Sulfur metabolism_Homo sapiens_hsa009201.36341512
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35116445
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33333557
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.31928361
42Type II diabetes mellitus_Homo sapiens_hsa049301.31907608
43Vibrio cholerae infection_Homo sapiens_hsa051101.22896151
44cAMP signaling pathway_Homo sapiens_hsa040241.21133354
45Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.20474943
46Salivary secretion_Homo sapiens_hsa049701.20153233
47Oxytocin signaling pathway_Homo sapiens_hsa049211.19980549
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18435919
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.14675883
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11182172
51Propanoate metabolism_Homo sapiens_hsa006401.08540435
52Gastric acid secretion_Homo sapiens_hsa049711.05669748
53Arachidonic acid metabolism_Homo sapiens_hsa005901.04213882
54Thyroid cancer_Homo sapiens_hsa052161.03936196
55Vitamin B6 metabolism_Homo sapiens_hsa007501.01021652
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.99229448
57Selenocompound metabolism_Homo sapiens_hsa004500.98816287
58Complement and coagulation cascades_Homo sapiens_hsa046100.93462609
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93179667
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.92699055
61Cardiac muscle contraction_Homo sapiens_hsa042600.88351768
62Calcium signaling pathway_Homo sapiens_hsa040200.88196767
63Glucagon signaling pathway_Homo sapiens_hsa049220.87704774
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87011664
65Dilated cardiomyopathy_Homo sapiens_hsa054140.87011651
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.85644007
67Estrogen signaling pathway_Homo sapiens_hsa049150.84537513
68Melanogenesis_Homo sapiens_hsa049160.83671572
69GnRH signaling pathway_Homo sapiens_hsa049120.83623178
70Axon guidance_Homo sapiens_hsa043600.82967387
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82840327
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82046215
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.81227760
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79445718
75Nitrogen metabolism_Homo sapiens_hsa009100.78438469
76Long-term depression_Homo sapiens_hsa047300.76909045
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76516798
78Tight junction_Homo sapiens_hsa045300.76463327
79Thyroid hormone synthesis_Homo sapiens_hsa049180.75540958
80Prion diseases_Homo sapiens_hsa050200.74726726
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72378821
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72291326
83Fatty acid metabolism_Homo sapiens_hsa012120.71079454
84Alzheimers disease_Homo sapiens_hsa050100.70696477
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70542569
86Oxidative phosphorylation_Homo sapiens_hsa001900.70521596
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69751292
88Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68489105
89Ether lipid metabolism_Homo sapiens_hsa005650.68385760
90PPAR signaling pathway_Homo sapiens_hsa033200.67751102
91Bile secretion_Homo sapiens_hsa049760.66685751
92Folate biosynthesis_Homo sapiens_hsa007900.66519583
93Type I diabetes mellitus_Homo sapiens_hsa049400.64851464
94Gap junction_Homo sapiens_hsa045400.64275998
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64240401
96Metabolic pathways_Homo sapiens_hsa011000.64093594
97ErbB signaling pathway_Homo sapiens_hsa040120.63720758
98ABC transporters_Homo sapiens_hsa020100.63354536
99Glioma_Homo sapiens_hsa052140.58297098
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57804262
101Pancreatic secretion_Homo sapiens_hsa049720.57565095
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57001572
103Adherens junction_Homo sapiens_hsa045200.56953244
104Steroid biosynthesis_Homo sapiens_hsa001000.56240217
105Butanoate metabolism_Homo sapiens_hsa006500.56106902
106Vitamin digestion and absorption_Homo sapiens_hsa049770.55555422
107Phenylalanine metabolism_Homo sapiens_hsa003600.55405630
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55355628
109Fat digestion and absorption_Homo sapiens_hsa049750.54424647
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53807227
111Protein export_Homo sapiens_hsa030600.52313996
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.50611202
113Endometrial cancer_Homo sapiens_hsa052130.50309454
114Chemical carcinogenesis_Homo sapiens_hsa052040.47001768
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46771109
116Regulation of autophagy_Homo sapiens_hsa041400.46714106
117Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45832039
118Ovarian steroidogenesis_Homo sapiens_hsa049130.45256947
119Fatty acid elongation_Homo sapiens_hsa000620.45048025
120Arginine biosynthesis_Homo sapiens_hsa002200.44927068
121Lysine degradation_Homo sapiens_hsa003100.43816075
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42513836
123Ras signaling pathway_Homo sapiens_hsa040140.41337098
124Wnt signaling pathway_Homo sapiens_hsa043100.40897236
125Linoleic acid metabolism_Homo sapiens_hsa005910.40753472
126Choline metabolism in cancer_Homo sapiens_hsa052310.40087768
127N-Glycan biosynthesis_Homo sapiens_hsa005100.39372050
128Arginine and proline metabolism_Homo sapiens_hsa003300.39269264
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38859177
130Starch and sucrose metabolism_Homo sapiens_hsa005000.38837074
131Mineral absorption_Homo sapiens_hsa049780.38297352
132Alcoholism_Homo sapiens_hsa050340.38251494
133alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37754628
134Huntingtons disease_Homo sapiens_hsa050160.37202115
135Fatty acid degradation_Homo sapiens_hsa000710.37080528
136Dorso-ventral axis formation_Homo sapiens_hsa043200.36587980
137Glycerolipid metabolism_Homo sapiens_hsa005610.36385479
138Parkinsons disease_Homo sapiens_hsa050120.36276297
139Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33850410
140Central carbon metabolism in cancer_Homo sapiens_hsa052300.33827815
141Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32126456
142Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31525019
143Cyanoamino acid metabolism_Homo sapiens_hsa004600.31044360
144Oocyte meiosis_Homo sapiens_hsa041140.30863473
145Steroid hormone biosynthesis_Homo sapiens_hsa001400.29968662
146Fatty acid biosynthesis_Homo sapiens_hsa000610.29728236
147Pyruvate metabolism_Homo sapiens_hsa006200.29294841
148Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28672804
149Melanoma_Homo sapiens_hsa052180.28650255
150Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25950009
151Insulin resistance_Homo sapiens_hsa049310.24233888
152Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.18900172

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »