CHSY3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CSS3 is a glycosyltransferase that has both glucuronyltransferase and N-acetylgalactosaminyltransferase activities (Yada et al., 2003 [PubMed 12907687]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ketone body metabolic process (GO:1902224)7.16959480
2phenol-containing compound biosynthetic process (GO:0046189)7.11909242
3developmental pigmentation (GO:0048066)7.01135725
4secondary metabolic process (GO:0019748)6.94638034
5endodermal cell differentiation (GO:0035987)5.84508853
6retina vasculature morphogenesis in camera-type eye (GO:0061299)4.70131781
7cell adhesion mediated by integrin (GO:0033627)4.49357263
8melanocyte differentiation (GO:0030318)4.44420538
9wound healing, spreading of epidermal cells (GO:0035313)4.42463603
10sequestering of extracellular ligand from receptor (GO:0035581)4.38170507
11pigment biosynthetic process (GO:0046148)4.38049996
12chondrocyte proliferation (GO:0035988)4.37675373
13substrate-dependent cell migration (GO:0006929)4.35493732
14negative regulation of chondrocyte differentiation (GO:0032331)4.34950194
15protein heterotrimerization (GO:0070208)4.28977265
16aromatic amino acid family metabolic process (GO:0009072)4.23360922
17positive regulation of macrophage activation (GO:0043032)4.22621110
18collagen metabolic process (GO:0032963)4.05092037
19extracellular fibril organization (GO:0043206)4.01516803
20cell migration involved in heart development (GO:0060973)3.99996575
21pigment cell differentiation (GO:0050931)3.98949813
22basement membrane organization (GO:0071711)3.94982868
23collagen catabolic process (GO:0030574)3.93631828
24myotube differentiation (GO:0014902)3.92077754
25mesodermal cell differentiation (GO:0048333)3.89970365
26vascular endothelial growth factor signaling pathway (GO:0038084)3.80227700
27skin morphogenesis (GO:0043589)3.79104902
28multicellular organismal macromolecule metabolic process (GO:0044259)3.75023090
29regulation of gonadotropin secretion (GO:0032276)3.73924728
30short-chain fatty acid metabolic process (GO:0046459)3.73561902
31regulation of endothelial cell chemotaxis (GO:2001026)3.73120406
32mesenchymal-epithelial cell signaling (GO:0060638)3.68793391
33endothelial cell morphogenesis (GO:0001886)3.67810631
34regulation of short-term neuronal synaptic plasticity (GO:0048172)3.66957901
35lymphangiogenesis (GO:0001946)3.63600985
36melanosome organization (GO:0032438)3.59984097
37multicellular organismal metabolic process (GO:0044236)3.56814791
38multicellular organismal catabolic process (GO:0044243)3.56565843
39substrate adhesion-dependent cell spreading (GO:0034446)3.56236907
40pigment metabolic process (GO:0042440)3.55990438
41cellular glucuronidation (GO:0052695)3.55316669
42glomerular basement membrane development (GO:0032836)3.53965965
43extracellular matrix disassembly (GO:0022617)3.51408530
44bone trabecula formation (GO:0060346)3.39255811
45pigment granule organization (GO:0048753)3.36678249
46endocrine hormone secretion (GO:0060986)3.35504021
47chondrocyte development (GO:0002063)3.34087931
48endothelium development (GO:0003158)3.30466801
49fibril organization (GO:0097435)3.29232745
50vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.27886154
51negative regulation of axon extension involved in axon guidance (GO:0048843)3.24898147
52neuron remodeling (GO:0016322)3.21055137
53axon extension involved in axon guidance (GO:0048846)3.18151169
54neuron projection extension involved in neuron projection guidance (GO:1902284)3.18151169
55glucuronate metabolic process (GO:0019585)3.18132998
56uronic acid metabolic process (GO:0006063)3.18132998
57cell migration involved in sprouting angiogenesis (GO:0002042)3.17306038
58negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.17109442
59negative regulation of cartilage development (GO:0061037)3.14966047
60kidney mesenchyme development (GO:0072074)3.12096154
61COPII vesicle coating (GO:0048208)3.11772213
62cell-substrate junction assembly (GO:0007044)3.11390527
63positive regulation of neuroblast proliferation (GO:0002052)3.09380425
64regulation of axon extension involved in axon guidance (GO:0048841)3.08636909
65negative regulation of response to reactive oxygen species (GO:1901032)3.08031851
66positive regulation of chemokine secretion (GO:0090197)3.07199526
67regulation of transforming growth factor beta2 production (GO:0032909)3.07193794
68cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.07107903
69positive regulation of blood vessel endothelial cell migration (GO:0043536)3.03645565
70peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.03636538
71positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)3.02629209
72wound healing, spreading of cells (GO:0044319)3.02375189
73cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.01081041
74extracellular matrix organization (GO:0030198)3.00477520
75melanin biosynthetic process (GO:0042438)21.1904056
76extracellular structure organization (GO:0043062)2.99587652
77positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.98632308
78patterning of blood vessels (GO:0001569)2.97081070
79sprouting angiogenesis (GO:0002040)2.96307070
80regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.94955105
81pathway-restricted SMAD protein phosphorylation (GO:0060389)2.94416291
82dermatan sulfate biosynthetic process (GO:0030208)2.94350876
83response to follicle-stimulating hormone (GO:0032354)2.92492864
84lymph vessel development (GO:0001945)2.91603247
85negative regulation of fibrinolysis (GO:0051918)2.91195397
86nerve growth factor signaling pathway (GO:0038180)2.90528516
87pigmentation (GO:0043473)2.89435888
88stress fiber assembly (GO:0043149)2.89336063
89collagen fibril organization (GO:0030199)2.89036603
90barbed-end actin filament capping (GO:0051016)2.88926338
91regulation of chemokine secretion (GO:0090196)2.88672644
92positive regulation of endothelial cell migration (GO:0010595)2.87309333
93neuroepithelial cell differentiation (GO:0060563)2.86986366
94hemoglobin metabolic process (GO:0020027)2.86698086
95semaphorin-plexin signaling pathway (GO:0071526)2.85072679
96protein retention in ER lumen (GO:0006621)2.84717725
97erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.84713765
98L-phenylalanine catabolic process (GO:0006559)2.84713765
99phenol-containing compound metabolic process (GO:0018958)2.84446716
100negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.84179833
101positive regulation of axon extension (GO:0045773)2.81829851
102protein localization to cell surface (GO:0034394)2.80169648
103L-phenylalanine metabolic process (GO:0006558)2.79509638
104erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.79509638
105regulation of hydrogen peroxide-induced cell death (GO:1903205)2.78951805
106apoptotic cell clearance (GO:0043277)2.76929482
107Notch signaling involved in heart development (GO:0061314)2.75661155
108metanephric mesenchyme development (GO:0072075)2.75208745
109regulation of chondrocyte differentiation (GO:0032330)2.74328328
110maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.73388170
111adherens junction assembly (GO:0034333)2.72779106
112neuronal action potential propagation (GO:0019227)2.71378447
113negative regulation of macrophage differentiation (GO:0045650)2.70566488
114heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.69963506
115cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.69438112
116dermatan sulfate metabolic process (GO:0030205)2.68294258
117regulation of endothelial cell differentiation (GO:0045601)2.67678177
118cellular ketone body metabolic process (GO:0046950)2.67546497
119regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.67331588
120protein localization to endosome (GO:0036010)2.66975077
121establishment of nucleus localization (GO:0040023)2.66902296
122paraxial mesoderm development (GO:0048339)2.65800981
123cell-substrate adherens junction assembly (GO:0007045)2.64792444
124focal adhesion assembly (GO:0048041)2.64792444
125synaptic vesicle exocytosis (GO:0016079)2.63789054
126regulation of fibrinolysis (GO:0051917)2.63560084
127regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.63460349
128COPI coating of Golgi vesicle (GO:0048205)2.63137780
129Golgi transport vesicle coating (GO:0048200)2.63137780
130regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.62537429
131hemidesmosome assembly (GO:0031581)2.61217665
132activin receptor signaling pathway (GO:0032924)2.60297770
133regulation of axon guidance (GO:1902667)2.60187210
134blood vessel remodeling (GO:0001974)2.59363738
135regulation of plasminogen activation (GO:0010755)2.56638120
136axonal fasciculation (GO:0007413)2.55028832
137positive regulation of osteoblast proliferation (GO:0033690)2.54517038
138insulin-like growth factor receptor signaling pathway (GO:0048009)2.52142547
139regulation of protein activation cascade (GO:2000257)2.42958343
140dicarboxylic acid biosynthetic process (GO:0043650)2.42066623
141bile acid biosynthetic process (GO:0006699)2.39823217
142glutamate secretion (GO:0014047)2.35791697
143regulation of neuroblast proliferation (GO:1902692)2.31405818
144peptidyl-glutamic acid carboxylation (GO:0017187)2.30684380
145protein carboxylation (GO:0018214)2.30684380
146aromatic amino acid family catabolic process (GO:0009074)2.29873209
147regulation of complement activation (GO:0030449)2.28732748
1484-hydroxyproline metabolic process (GO:0019471)2.25230879
149dendritic spine organization (GO:0097061)2.25055883
150layer formation in cerebral cortex (GO:0021819)2.24232200
151negative regulation of fatty acid biosynthetic process (GO:0045717)2.24189140
152triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.23306018
153synaptic vesicle maturation (GO:0016188)2.17054141
154regulation of long-term neuronal synaptic plasticity (GO:0048169)2.16341398
155positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.16140530
156cell aggregation (GO:0098743)2.14251914
157cartilage condensation (GO:0001502)2.14251914
158regulation of neuronal synaptic plasticity (GO:0048168)2.14230995
159kynurenine metabolic process (GO:0070189)2.14027724
160urea cycle (GO:0000050)2.13541325
161urea metabolic process (GO:0019627)2.13541325
162vocalization behavior (GO:0071625)2.11781705
163dendritic spine morphogenesis (GO:0060997)2.11387547
164glyoxylate metabolic process (GO:0046487)2.11149024
165tryptophan metabolic process (GO:0006568)2.11027898
166complement activation, alternative pathway (GO:0006957)2.10433285
167fibrinolysis (GO:0042730)2.09934956
168keratan sulfate catabolic process (GO:0042340)2.09164055
169Rap protein signal transduction (GO:0032486)2.08948793
170midgut development (GO:0007494)2.08479413
171synaptic vesicle docking involved in exocytosis (GO:0016081)2.07824033
172glutamate metabolic process (GO:0006536)2.07491824
173positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.07151913
174alpha-linolenic acid metabolic process (GO:0036109)2.05733521
175coenzyme catabolic process (GO:0009109)2.05681792
176high-density lipoprotein particle remodeling (GO:0034375)2.04575744
177neuron recognition (GO:0008038)2.03388236
178melanin metabolic process (GO:0006582)19.1463335
179secondary metabolite biosynthetic process (GO:0044550)17.7394951
180tyrosine metabolic process (GO:0006570)10.1934165
181cochlea development (GO:0090102)1.99021564
182locomotory exploration behavior (GO:0035641)1.98264924
183plasma lipoprotein particle clearance (GO:0034381)1.97265672
184regulation of cholesterol homeostasis (GO:2000188)1.97195627
185negative regulation of dendrite morphogenesis (GO:0050774)1.95182609
186positive regulation of glucose transport (GO:0010828)1.94652715
187cell-cell junction maintenance (GO:0045217)1.94648587
188neuronal ion channel clustering (GO:0045161)1.93419658

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.42871660
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.38342739
3TRIM28_21343339_ChIP-Seq_HEK293_Human2.94298169
4GBX2_23144817_ChIP-Seq_PC3_Human2.88742956
5EZH2_22144423_ChIP-Seq_EOC_Human2.61364261
6BRD4_25478319_ChIP-Seq_HGPS_Human2.51377597
7AR_21572438_ChIP-Seq_LNCaP_Human2.38889999
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.35771288
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.31844910
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.22718236
11RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.17481760
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.15048008
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.15048008
14* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.09325978
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.04216596
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.03168464
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.00182166
18LXR_22158963_ChIP-Seq_LIVER_Mouse2.00058520
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97517318
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.97205851
21TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.96010745
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.93247041
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.92847837
24CLOCK_20551151_ChIP-Seq_293T_Human1.91516228
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.89558068
26* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.88984386
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.88451020
28CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.87577780
29* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.83896266
30FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.81543021
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76235339
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.75949075
33SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.75270063
34DROSHA_22980978_ChIP-Seq_HELA_Human1.69352705
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.68415380
36PPARA_22158963_ChIP-Seq_LIVER_Mouse1.68218413
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.66520085
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.65588156
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64685975
40NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.63805076
41MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.63773530
42* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63598856
43* RNF2_27304074_Chip-Seq_ESCs_Mouse1.60734523
44HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.58452845
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.57540900
46ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.55985118
47SOX9_24532713_ChIP-Seq_HFSC_Mouse1.55197020
48EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.52963255
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52859953
50* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.51585413
51TP53_18474530_ChIP-ChIP_U2OS_Human1.51080240
52SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50555486
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.48112317
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.46413601
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42663932
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40975068
57TBX20_22080862_ChIP-Seq_HEART_Mouse1.40948779
58TBX20_22328084_ChIP-Seq_HEART_Mouse1.40948779
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.40375794
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.39732684
61RARB_27405468_Chip-Seq_BRAIN_Mouse1.39151398
62SALL4_18804426_ChIP-ChIP_XEN_Mouse1.38163870
63* SMAD4_21799915_ChIP-Seq_A2780_Human1.37890362
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37762434
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35779238
66SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.35131461
67SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.35131461
68NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.33522830
69NRF2_20460467_ChIP-Seq_MEFs_Mouse1.33522830
70TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.33228289
71ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32941295
72SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.32534701
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30013853
74P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29509536
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28563396
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.27697741
77SA1_22415368_ChIP-Seq_MEFs_Mouse1.27216366
78* P300_19829295_ChIP-Seq_ESCs_Human1.26988361
79* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25879888
80PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.23884672
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23004992
82NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22667473
83* ISL1_27105846_Chip-Seq_CPCs_Mouse1.21981886
84TAF15_26573619_Chip-Seq_HEK293_Human1.19889967
85CTNNB1_20460455_ChIP-Seq_HCT116_Human1.18943137
86ESR2_21235772_ChIP-Seq_MCF-7_Human1.18930621
87UBF1/2_26484160_Chip-Seq_HMECs_Human1.17743365
88* CJUN_26792858_Chip-Seq_BT549_Human1.16985175
89EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16218914
90WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14291985
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14170610
92TP53_16413492_ChIP-PET_HCT116_Human1.13897799
93SMC1_22415368_ChIP-Seq_MEFs_Mouse1.13702786
94RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13608846
95SMAD3_21741376_ChIP-Seq_HESCs_Human1.13098355
96EGR1_23403033_ChIP-Seq_LIVER_Mouse1.12275628
97FOXA2_19822575_ChIP-Seq_HepG2_Human1.11937651
98AR_25329375_ChIP-Seq_VCAP_Human1.09535626
99JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09293175
100HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09089977
101RING1B_27294783_Chip-Seq_ESCs_Mouse1.09078604
102GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08802512
103JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08729714
104TCF4_18268006_ChIP-ChIP_LS174T_Human1.08524205
105* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08472979
106NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08327844
107HTT_18923047_ChIP-ChIP_STHdh_Human1.07146291
108REST_21632747_ChIP-Seq_MESCs_Mouse1.05990157
109STAT3_23295773_ChIP-Seq_U87_Human1.05892394
110SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05404894
111BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03922578
112BCAT_22108803_ChIP-Seq_LS180_Human1.03008754
113AR_21909140_ChIP-Seq_LNCAP_Human1.02614464
114TP53_23651856_ChIP-Seq_MEFs_Mouse1.02421373
115TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02384181
116DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01977948
117YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01363367
118ARNT_22903824_ChIP-Seq_MCF-7_Human1.01335903
119WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00530552
120TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00360027
121TBX3_20139965_ChIP-Seq_MESCs_Mouse1.00178639
122TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99381110
123EGR1_19032775_ChIP-ChIP_M12_Human0.98861382
124ELK3_25401928_ChIP-Seq_HUVEC_Human0.98405526
125TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97625223
126TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97056259
127BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96036209
128JUN_21703547_ChIP-Seq_K562_Human0.95858650
129SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95159500
130ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.94076849
131SMC3_22415368_ChIP-Seq_MEFs_Mouse0.93580133
132GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93486022
133AR_19668381_ChIP-Seq_PC3_Human0.92982256
134AHR_22903824_ChIP-Seq_MCF-7_Human0.92210477
135WT1_19549856_ChIP-ChIP_CCG9911_Human0.91926877
136ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91786402
137PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.91489551
138TP53_22127205_ChIP-Seq_IMR90_Human0.90509334
139KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.90465558
140EP300_21415370_ChIP-Seq_HL-1_Mouse0.89852844
141RING1B_27294783_Chip-Seq_NPCs_Mouse0.89580358
142NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.89533601
143TP53_20018659_ChIP-ChIP_R1E_Mouse0.89254695
144REST_18959480_ChIP-ChIP_MESCs_Mouse0.89000428
145CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.88613996
146PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88417558
147MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.88306075
148PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88262467

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation9.81651587
2MP0005171_absent_coat_pigmentation8.97065848
3MP0005408_hypopigmentation5.25218490
4MP0003136_yellow_coat_color4.19903422
5MP0000371_diluted_coat_color3.73599687
6MP0010368_abnormal_lymphatic_system3.64453590
7MP0005257_abnormal_intraocular_pressure3.62411884
8MP0004381_abnormal_hair_follicle3.43369768
9MP0003279_aneurysm3.36911289
10MP0002877_abnormal_melanocyte_morpholog2.86251490
11MP0002095_abnormal_skin_pigmentation2.41613869
12MP0000015_abnormal_ear_pigmentation2.33382239
13MP0001324_abnormal_eye_pigmentation2.33346250
14MP0002102_abnormal_ear_morphology2.23637503
15MP0005377_hearing/vestibular/ear_phenot2.22222058
16MP0003878_abnormal_ear_physiology2.22222058
17MP0002139_abnormal_hepatobiliary_system2.10211337
18MP0000767_abnormal_smooth_muscle2.04597254
19MP0000013_abnormal_adipose_tissue2.02742830
20MP0005248_abnormal_Harderian_gland2.02254260
21MP0005187_abnormal_penis_morphology1.99594350
22MP0001879_abnormal_lymphatic_vessel1.98785670
23MP0002075_abnormal_coat/hair_pigmentati1.98677051
24MP0000569_abnormal_digit_pigmentation1.96992817
25MP0010030_abnormal_orbit_morphology1.93743311
26MP0006054_spinal_hemorrhage1.87382565
27MP0003950_abnormal_plasma_membrane1.84272451
28MP0003705_abnormal_hypodermis_morpholog1.75866780
29MP0008438_abnormal_cutaneous_collagen1.70152613
30MP0004859_abnormal_synaptic_plasticity1.67139856
31MP0005503_abnormal_tendon_morphology1.61256922
32MP0002060_abnormal_skin_morphology1.59405279
33MP0005075_abnormal_melanosome_morpholog1.55389257
34MP0001186_pigmentation_phenotype1.52952856
35MP0003941_abnormal_skin_development1.52001252
36MP0001542_abnormal_bone_strength1.50998994
37MP0000534_abnormal_ureter_morphology1.48946550
38MP0004885_abnormal_endolymph1.43550643
39MP0005360_urolithiasis1.41174646
40MP0004084_abnormal_cardiac_muscle1.40516392
41MP0002938_white_spotting1.36154962
42MP0005670_abnormal_white_adipose1.35552144
43MP0000749_muscle_degeneration1.32048085
44MP0005595_abnormal_vascular_smooth1.27221024
45MP0005197_abnormal_uvea_morphology1.25588736
46MP0005174_abnormal_tail_pigmentation1.21127350
47MP0005085_abnormal_gallbladder_physiolo1.20095601
48MP0010352_gastrointestinal_tract_polyps1.16133441
49MP0002090_abnormal_vision1.15895783
50MP0009384_cardiac_valve_regurgitation1.15217939
51MP0001915_intracranial_hemorrhage1.10999004
52MP0009053_abnormal_anal_canal1.07361677
53MP0002089_abnormal_postnatal_growth/wei1.05492695
54MP0005083_abnormal_biliary_tract1.02435821
55MP0001661_extended_life_span1.01121335
56MP0001243_abnormal_dermal_layer0.97548380
57MP0000003_abnormal_adipose_tissue0.97181926
58MP0003942_abnormal_urinary_system0.97175451
59MP0003315_abnormal_perineum_morphology0.96897053
60MP0003329_amyloid_beta_deposits0.95495521
61MP0002128_abnormal_blood_circulation0.92868174
62MP0000537_abnormal_urethra_morphology0.92458203
63MP0004036_abnormal_muscle_relaxation0.91856740
64MP0009780_abnormal_chondrocyte_physiolo0.91653675
65MP0003755_abnormal_palate_morphology0.91522784
66MP0005275_abnormal_skin_tensile0.90441160
67MP0003300_gastrointestinal_ulcer0.90405483
68MP0001614_abnormal_blood_vessel0.89819997
69MP0003935_abnormal_craniofacial_develop0.87449014
70MP0005365_abnormal_bile_salt0.87365073
71MP0000759_abnormal_skeletal_muscle0.86944504
72MP0003283_abnormal_digestive_organ0.86089114
73MP0003635_abnormal_synaptic_transmissio0.85961901
74MP0009046_muscle_twitch0.85151139
75MP0010234_abnormal_vibrissa_follicle0.82141163
76MP0000432_abnormal_head_morphology0.81238124
77MP0000428_abnormal_craniofacial_morphol0.80886491
78MP0005165_increased_susceptibility_to0.80403451
79MP0003828_pulmonary_edema0.77137950
80MP0002925_abnormal_cardiovascular_devel0.76107978
81MP0002932_abnormal_joint_morphology0.75917567
82MP0000049_abnormal_middle_ear0.75541448
83MP0005023_abnormal_wound_healing0.75134654
84MP0000462_abnormal_digestive_system0.73971323
85MP0002282_abnormal_trachea_morphology0.72576854
86MP0002113_abnormal_skeleton_development0.72489250
87MP0002063_abnormal_learning/memory/cond0.72432893
88MP0004087_abnormal_muscle_fiber0.71906894
89MP0000762_abnormal_tongue_morphology0.71902537
90MP0002697_abnormal_eye_size0.71880597
91MP0005390_skeleton_phenotype0.71796053
92MP0002638_abnormal_pupillary_reflex0.71570447
93MP0005409_darkened_coat_color0.71445732
94MP0009697_abnormal_copulation0.71204114
95MP0005623_abnormal_meninges_morphology0.70126297
96MP0001849_ear_inflammation0.69987143
97MP0009745_abnormal_behavioral_response0.69633279
98MP0004134_abnormal_chest_morphology0.68325546
99MP0010386_abnormal_urinary_bladder0.68182264
100MP0001299_abnormal_eye_distance/0.67933858
101MP0003252_abnormal_bile_duct0.66739407
102MP0002064_seizures0.65293245
103MP0000750_abnormal_muscle_regeneration0.65224170
104MP0005388_respiratory_system_phenotype0.65048847
105MP0002133_abnormal_respiratory_system0.65048847
106MP0005620_abnormal_muscle_contractility0.64979254
107MP0002114_abnormal_axial_skeleton0.63551436
108MP0000343_altered_response_to0.63479492
109MP0002116_abnormal_craniofacial_bone0.62382502
110MP0003566_abnormal_cell_adhesion0.61019783
111MP0003091_abnormal_cell_migration0.61003387
112MP0010329_abnormal_lipoprotein_level0.60792730
113MP0009840_abnormal_foam_cell0.59681790
114MP0008875_abnormal_xenobiotic_pharmacok0.59440725
115MP0003937_abnormal_limbs/digits/tail_de0.59026268
116MP0000163_abnormal_cartilage_morphology0.58815469
117MP0001958_emphysema0.58506664
118MP0000751_myopathy0.58351548
119MP0005369_muscle_phenotype0.57204224
120MP0004858_abnormal_nervous_system0.57057965
121MP0004270_analgesia0.56210714
122MP0000747_muscle_weakness0.56171332
123MP0002168_other_aberrant_phenotype0.56095651
124MP0004272_abnormal_basement_membrane0.55757591
125MP0002109_abnormal_limb_morphology0.55619871
126MP0001177_atelectasis0.55272648
127MP0003448_altered_tumor_morphology0.55166652
128MP0005508_abnormal_skeleton_morphology0.54843609
129MP0010630_abnormal_cardiac_muscle0.54808791
130MP0006138_congestive_heart_failure0.51887718
131MP0002295_abnormal_pulmonary_circulatio0.51185214
132MP0009250_abnormal_appendicular_skeleto0.50707917
133MP0005386_behavior/neurological_phenoty0.50204585
134MP0004924_abnormal_behavior0.50204585
135MP0000955_abnormal_spinal_cord0.50016620
136MP0002115_abnormal_skeleton_extremities0.48889750
137MP0003880_abnormal_central_pattern0.46344701
138MP0002108_abnormal_muscle_morphology0.46105059
139MP0000733_abnormal_muscle_development0.46090466
140MP0001486_abnormal_startle_reflex0.43859781
141MP0000604_amyloidosis0.43722005
142MP0002896_abnormal_bone_mineralization0.43483610
143MP0001293_anophthalmia0.42523142
144MP0003646_muscle_fatigue0.42348299
145MP0003690_abnormal_glial_cell0.42338031
146MP0002572_abnormal_emotion/affect_behav0.42057461
147MP0001666_abnormal_nutrient_absorption0.40308284
148MP0003385_abnormal_body_wall0.38551192
149MP0000367_abnormal_coat/_hair0.38046448
150MP0000920_abnormal_myelination0.38042238
151MP0001968_abnormal_touch/_nociception0.37853800
152MP0002184_abnormal_innervation0.37571598
153MP0003453_abnormal_keratinocyte_physiol0.36576309
154MP0002272_abnormal_nervous_system0.35992381
155MP0003191_abnormal_cellular_cholesterol0.35839715
156MP0004233_abnormal_muscle_weight0.33985797
157MP0005193_abnormal_anterior_eye0.33961198
158MP0002092_abnormal_eye_morphology0.32625509
159MP0003868_abnormal_feces_composition0.31980673
160MP0002933_joint_inflammation0.30592089
161MP0003195_calcinosis0.30537790
162MP0001485_abnormal_pinna_reflex0.30475624
163MP0002177_abnormal_outer_ear0.29893663

Predicted human phenotypes

RankGene SetZ-score
1Blue irides (HP:0000635)8.72485256
2Aplasia/Hypoplasia of the macula (HP:0008059)8.29479199
3Aplasia/Hypoplasia affecting the retina (HP:0008061)7.77644527
4Hypoplasia of the fovea (HP:0007750)7.19347916
5Aplasia/Hypoplasia of the fovea (HP:0008060)7.19347916
6Aortic dissection (HP:0002647)6.21602263
7Ocular albinism (HP:0001107)6.18328472
8Abnormality of the fovea (HP:0000493)5.90443745
9Iris hypopigmentation (HP:0007730)5.51355248
10Soft skin (HP:0000977)5.07235154
11Hypopigmentation of the fundus (HP:0007894)4.92004993
12Generalized hypopigmentation (HP:0007513)4.78932573
13Subacute progressive viral hepatitis (HP:0006572)4.78846851
14Epiphyseal dysplasia (HP:0002656)4.56289732
15Atrophic scars (HP:0001075)4.49094265
16Cerebral aneurysm (HP:0004944)4.31033101
17Hypoplasia of the iris (HP:0007676)4.27005346
18Arterial tortuosity (HP:0005116)4.22456928
19Fragile skin (HP:0001030)4.15046210
20Bladder diverticulum (HP:0000015)4.04513452
21White forelock (HP:0002211)3.96173550
22Congenital sensorineural hearing impairment (HP:0008527)3.93904456
23Abnormality of dentin (HP:0010299)3.93146802
24Follicular hyperkeratosis (HP:0007502)3.85022915
25Peritonitis (HP:0002586)3.73836034
26Genu recurvatum (HP:0002816)3.70420649
27Mitral valve prolapse (HP:0001634)3.64063831
28Small epiphyses (HP:0010585)3.63110912
29Generalized hypopigmentation of hair (HP:0011358)3.61926486
30Blue sclerae (HP:0000592)3.45480913
31Dilatation of the ascending aorta (HP:0005111)3.42978458
32Patchy hypopigmentation of hair (HP:0011365)3.40534584
33Bilateral sensorineural hearing impairment (HP:0008619)3.33616792
34Deep venous thrombosis (HP:0002625)3.26983851
35Mild short stature (HP:0003502)3.26356775
36Shallow orbits (HP:0000586)3.23172478
37Wormian bones (HP:0002645)3.21840405
38Spinal rigidity (HP:0003306)3.15995357
39Irregular epiphyses (HP:0010582)3.15735618
40Spondylolisthesis (HP:0003302)3.11060099
41Heterochromia iridis (HP:0001100)3.10918164
42Broad metatarsal (HP:0001783)3.07943823
43Ankle contracture (HP:0006466)3.06129422
44Vitreoretinal degeneration (HP:0000655)2.99712524
45Hyperextensible skin (HP:0000974)2.97043632
46Type 1 muscle fiber predominance (HP:0003803)2.92608310
47Osteolytic defects of the phalanges of the hand (HP:0009771)2.92146334
48Osteolytic defects of the hand bones (HP:0009699)2.92146334
49Abnormal tarsal ossification (HP:0008369)2.89629081
50Hepatocellular carcinoma (HP:0001402)2.88501980
51Abnormal delivery (HP:0001787)2.87704249
52Overgrowth (HP:0001548)2.87533899
53Cutaneous melanoma (HP:0012056)2.85656063
54Bowel diverticulosis (HP:0005222)2.76607426
55Mitral stenosis (HP:0001718)2.75816386
56Premature rupture of membranes (HP:0001788)2.70484550
57Joint laxity (HP:0001388)2.65461549
58Ulnar bowing (HP:0003031)2.65146403
59Biconcave vertebral bodies (HP:0004586)2.64707304
60Freckling (HP:0001480)2.60356831
61Viral hepatitis (HP:0006562)2.58733672
62Abnormal gallbladder physiology (HP:0012438)2.57006323
63Cholecystitis (HP:0001082)2.57006323
64Metaphyseal cupping (HP:0003021)2.56811536
65Neonatal short-limb short stature (HP:0008921)2.54937481
66Aortic regurgitation (HP:0001659)2.54537728
67Wide anterior fontanel (HP:0000260)2.48366017
68Hypoplastic ischia (HP:0003175)2.47697578
69Cupped ribs (HP:0000887)2.47115205
70Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.39288137
71Xanthomatosis (HP:0000991)2.37167695
72Aneurysm (HP:0002617)2.34599131
73Abnormality of the acetabulum (HP:0003170)2.31675378
74Delayed epiphyseal ossification (HP:0002663)2.29818654
75Increased variability in muscle fiber diameter (HP:0003557)2.28233468
76Disproportionate tall stature (HP:0001519)2.23902868
77Abnormality of the ischium (HP:0003174)2.22541065
78Abnormality of the vertebral endplates (HP:0005106)2.22419087
79Micronodular cirrhosis (HP:0001413)2.22058736
80Intrahepatic cholestasis (HP:0001406)2.21717429
81Protrusio acetabuli (HP:0003179)2.21602258
82Irregular vertebral endplates (HP:0003301)2.20926623
83Vertebral compression fractures (HP:0002953)2.16314613
84Metaphyseal dysplasia (HP:0100255)2.15483833
85Infantile muscular hypotonia (HP:0008947)2.15010099
86Cardiovascular calcification (HP:0011915)2.14182678
87Spinal cord compression (HP:0002176)2.13781818
88Short nail (HP:0001799)2.12521130
89Venous insufficiency (HP:0005293)2.08241564
90Osteoarthritis (HP:0002758)2.08057593
91Ovoid vertebral bodies (HP:0003300)2.07923489
92Venous abnormality (HP:0002624)2.06941624
93Round ear (HP:0100830)2.06262938
94Mitral regurgitation (HP:0001653)2.06160954
95Abnormal foot bone ossification (HP:0010675)2.05284408
96Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.04934301
97Elbow flexion contracture (HP:0002987)2.03999879
98Flat capital femoral epiphysis (HP:0003370)2.03255339
99Limited hip movement (HP:0008800)2.02440731
100Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.00483580
101Slender build (HP:0001533)2.00052219
102Knee flexion contracture (HP:0006380)1.98939840
103Flat cornea (HP:0007720)1.97575934
104Genu varum (HP:0002970)1.97316894
105Nonimmune hydrops fetalis (HP:0001790)1.96629984
106Wrist flexion contracture (HP:0001239)1.94572098
107Relative macrocephaly (HP:0004482)1.93873107
108Mesomelia (HP:0003027)1.93786103
109Abnormality of skeletal muscle fiber size (HP:0012084)1.93128862
110Alopecia of scalp (HP:0002293)1.92877544
111Focal motor seizures (HP:0011153)1.91426304
112Focal seizures (HP:0007359)1.89849841
113Coxa vara (HP:0002812)1.89043498
114Hand muscle atrophy (HP:0009130)1.88264380
115Exostoses (HP:0100777)1.86717371
116Spastic diplegia (HP:0001264)1.86710040
117Aortic aneurysm (HP:0004942)1.86224063
118Myokymia (HP:0002411)1.85509257
119Inguinal hernia (HP:0000023)1.84989727
120Syringomyelia (HP:0003396)1.84067101
121Spinal cord lesions (HP:0100561)1.84067101
122Mildly elevated creatine phosphokinase (HP:0008180)1.81477804
123Breech presentation (HP:0001623)1.81399357
124Striae distensae (HP:0001065)1.80739044
125Distal upper limb amyotrophy (HP:0007149)1.80120403
126Upper limb amyotrophy (HP:0009129)1.80120403
127Protuberant abdomen (HP:0001538)1.80018788
128Flattened epiphyses (HP:0003071)1.78048556
129Thin skin (HP:0000963)1.77363003
130Delayed closure of the anterior fontanelle (HP:0001476)1.76196633
131Retinal detachment (HP:0000541)1.76066579
132Renal duplication (HP:0000075)1.75527052
133Aortic valve stenosis (HP:0001650)1.75392325
134Tetraparesis (HP:0002273)1.74857327
135Hypobetalipoproteinemia (HP:0003563)1.73997442
136Hallux valgus (HP:0001822)1.73415039
137Camptodactyly of toe (HP:0001836)1.73339019
138Vascular tortuosity (HP:0004948)1.72715359
139Narrow nasal bridge (HP:0000446)1.72601647
140Broad long bones (HP:0005622)1.72464883
141Arachnodactyly (HP:0001166)1.71728442
142Arthropathy (HP:0003040)1.70660658
143Enlarged epiphyses (HP:0010580)1.70303281
144Hip contracture (HP:0003273)1.69789681
145Deviation of the hallux (HP:0010051)1.69728581
146Keratoconus (HP:0000563)1.69513507
147Increased corneal curvature (HP:0100692)1.69513507
148Abnormality of aromatic amino acid family metabolism (HP:0004338)1.69000163
149Pulmonary artery stenosis (HP:0004415)1.68531066
150Scapular winging (HP:0003691)1.67910179
151Congenital glaucoma (HP:0001087)1.67791694
152Abnormality of femoral epiphyses (HP:0006499)1.66806488
153Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.66806488
154Increased connective tissue (HP:0009025)1.66480227
155Absent frontal sinuses (HP:0002688)1.66235823
156Bowed forearm bones (HP:0003956)1.66233176
157Bowing of the arm (HP:0006488)1.66233176
158Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.66161126
159Hypoalphalipoproteinemia (HP:0003233)1.65672316
160Flat acetabular roof (HP:0003180)1.65236932
161Platyspondyly (HP:0000926)1.64405597
162Lower limb asymmetry (HP:0100559)1.63462413
163Abnormality of the anterior chamber (HP:0000593)1.61659113
164Hyperlipoproteinemia (HP:0010980)1.61317928
165Prolonged partial thromboplastin time (HP:0003645)1.60626130
166Broad ribs (HP:0000885)1.60460530
167Albinism (HP:0001022)1.59853827
168Hypolipoproteinemia (HP:0010981)1.58556573
169Abnormality of glutamine family amino acid metabolism (HP:0010902)1.57140965
170Joint stiffness (HP:0001387)1.54989595
171Waddling gait (HP:0002515)1.54977065
172Hypoplasia of the odontoid process (HP:0003311)1.52866403
173Abnormality of proline metabolism (HP:0010907)1.52452325
174Hydroxyprolinuria (HP:0003080)1.52452325
175Abnormality of vision evoked potentials (HP:0000649)1.52359584
176Torticollis (HP:0000473)1.50235569
177Premature graying of hair (HP:0002216)1.49984061
178Abnormality of the epiphysis of the femoral head (HP:0010574)1.49152775
179Abnormality of monocarboxylic acid metabolism (HP:0010996)1.49109650
180Synostosis of carpal bones (HP:0005048)1.48950910
181Cervical subluxation (HP:0003308)1.48117990
182Ectopia lentis (HP:0001083)1.47378257

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MET4.94854924
2MYLK3.69840959
3TIE13.68949667
4BMX3.47644519
5TGFBR22.92051196
6CLK12.86892134
7MARK32.66132665
8NEK92.64389539
9PKN22.62519355
10DDR22.41916974
11PAK22.41395220
12EPHA42.33541475
13KSR12.17803031
14LIMK12.07411453
15TRIB32.04585940
16MST1R10.7524186
17NTRK11.93686875
18EPHA31.82090522
19MAP3K91.73709121
20KDR1.66331306
21TESK11.58693737
22PAK41.57198943
23PAK61.51677816
24STK381.43938346
25MARK11.42886284
26KSR21.39647323
27PLK21.39601316
28CAMKK11.34895209
29MOS1.33116933
30DAPK21.25592133
31LATS11.23765285
32NTRK31.18088343
33TRPM71.17864665
34ILK1.10230380
35STK31.09466002
36PIK3CG1.08949705
37SCYL21.08636518
38ICK1.04152678
39LATS21.03924982
40PNCK1.02948602
41MTOR1.02831196
42WEE11.02307868
43PRPF4B0.99510352
44SIK10.99331372
45STK38L0.95521687
46OBSCN0.94409618
47MINK10.93231221
48MAP3K40.92481552
49ROCK20.89630788
50NTRK20.89257066
51PAK30.88656590
52BCR0.87512362
53PINK10.84998911
54CDK30.84150874
55RET0.84007380
56CSNK1G20.76702095
57FER0.75247188
58MAP3K60.72940103
59FLT30.72618790
60PRKG20.72520453
61EEF2K0.71562744
62CDC42BPA0.69124597
63CAMKK20.68144612
64CDK60.67599821
65GSK3A0.65997913
66DAPK30.65810276
67EPHB20.65177749
68ERBB40.64519246
69MAP2K40.64440685
70LMTK20.64185488
71MAP3K20.64139538
72TTN0.62556942
73CDK50.62221534
74PTK2B0.59732240
75MAP2K10.59728850
76PRKD30.59331733
77PTK60.59046872
78MAP3K120.58895486
79PRKD20.56675752
80PRKCE0.56631121
81FRK0.56470747
82CASK0.56368797
83MAPKAPK50.56212413
84CDK90.56024179
85CSNK1A1L0.54755374
86PRKCZ0.52601959
87MAPK70.52393762
88RAF10.52297476
89DMPK0.51423076
90ABL20.51265861
91PDGFRA0.51185456
92ERBB20.49243030
93CDK190.49118609
94RIPK10.49084479
95CSNK1G30.48796229
96PTK20.48071366
97MAP3K130.47168320
98STK240.46602165
99MAP3K30.46141742
100SIK20.46067097
101CDK120.45095745
102CSNK1G10.44825527
103CAMK2G0.43316149
104PIK3CA0.42777159
105MELK0.42382173
106CDK11A0.41337559
107SGK30.40209051
108MAPK120.40062598
109CDK180.38983702
110SGK20.38691538
111EIF2AK30.38607852
112TAOK20.38073448
113MAP2K70.37266656
114RPS6KA20.37103127
115ARAF0.36713534
116CAMK2A0.35945621
117FGFR10.35888832
118EPHB10.35209682
119FGR0.35089053
120TGFBR10.34160305
121CAMK2D0.34134422
122OXSR10.33988583
123CDK150.33457113
124DAPK10.33180772
125ADRBK10.32710033
126SGK2230.32618317
127SGK4940.32618317
128SIK30.32517998
129CAMK1G0.32357428
130INSR0.31950063
131PBK0.31741301
132MAP2K30.31641037
133PHKG20.31561591
134PHKG10.31561591
135ROCK10.31136917
136AKT20.30779020
137TYRO30.30733594
138ERBB30.30662010
139FYN0.30065711
140FGFR40.29894269
141WNK10.28898229
142TESK20.28245477
143CAMK2B0.27976820
144NEK60.27595595
145CCNB10.27216221
146CDK140.26573293
147PDPK10.26026079
148SRC0.25611432
149PDGFRB0.24877548
150PRKCH0.24698601
151SGK10.24356819
152PDK10.23824356
153GRK50.23365512
154ADRBK20.22735681
155STK110.22040278

Predicted pathways (KEGG)

RankGene SetZ-score
1Tyrosine metabolism_Homo sapiens_hsa003504.60921490
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.97797951
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.83184313
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.72819195
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.59491429
6Dilated cardiomyopathy_Homo sapiens_hsa054142.57012573
7Nitrogen metabolism_Homo sapiens_hsa009102.50220611
8Amoebiasis_Homo sapiens_hsa051462.20083017
9Melanogenesis_Homo sapiens_hsa049162.12014307
10TGF-beta signaling pathway_Homo sapiens_hsa043502.06379991
11Small cell lung cancer_Homo sapiens_hsa052222.04559761
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.99236194
13AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.96523300
14Arginine biosynthesis_Homo sapiens_hsa002201.96493591
15Hippo signaling pathway_Homo sapiens_hsa043901.73918462
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.72033405
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.71415896
18Complement and coagulation cascades_Homo sapiens_hsa046101.70954063
19Butanoate metabolism_Homo sapiens_hsa006501.65511110
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.55826903
21Starch and sucrose metabolism_Homo sapiens_hsa005001.54903542
22PI3K-Akt signaling pathway_Homo sapiens_hsa041511.50842121
23Synaptic vesicle cycle_Homo sapiens_hsa047211.43937931
24Regulation of actin cytoskeleton_Homo sapiens_hsa048101.40672168
25Bile secretion_Homo sapiens_hsa049761.35879900
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.32226218
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.32016516
28Olfactory transduction_Homo sapiens_hsa047401.31981847
29Axon guidance_Homo sapiens_hsa043601.31241659
30Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.30781196
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.27665960
32ECM-receptor interaction_Homo sapiens_hsa045121.24997317
33Hedgehog signaling pathway_Homo sapiens_hsa043401.22436344
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.19302416
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.17258422
36Circadian entrainment_Homo sapiens_hsa047131.15810819
37Basal cell carcinoma_Homo sapiens_hsa052171.12274709
38Nicotine addiction_Homo sapiens_hsa050331.10816122
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.09263133
40Wnt signaling pathway_Homo sapiens_hsa043101.09057617
41Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.08767907
42Steroid biosynthesis_Homo sapiens_hsa001001.08613478
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08049494
44Renal cell carcinoma_Homo sapiens_hsa052111.06008001
45Salivary secretion_Homo sapiens_hsa049701.05986019
46GABAergic synapse_Homo sapiens_hsa047271.05466987
47Pathways in cancer_Homo sapiens_hsa052001.04719091
48Aldosterone synthesis and secretion_Homo sapiens_hsa049251.02677125
49Galactose metabolism_Homo sapiens_hsa000521.02284312
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01741020
51Focal adhesion_Homo sapiens_hsa045100.97482767
52Tryptophan metabolism_Homo sapiens_hsa003800.96336993
53MicroRNAs in cancer_Homo sapiens_hsa052060.96111570
54Bladder cancer_Homo sapiens_hsa052190.93966922
55Melanoma_Homo sapiens_hsa052180.92940356
56Tight junction_Homo sapiens_hsa045300.91969337
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88806583
58Biosynthesis of amino acids_Homo sapiens_hsa012300.87966238
59Glioma_Homo sapiens_hsa052140.87102209
60Long-term potentiation_Homo sapiens_hsa047200.87096310
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86421772
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85124143
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.83854738
64Chronic myeloid leukemia_Homo sapiens_hsa052200.83530538
65Fatty acid metabolism_Homo sapiens_hsa012120.83221432
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83018858
67Glutamatergic synapse_Homo sapiens_hsa047240.81881480
68Sulfur metabolism_Homo sapiens_hsa009200.81542676
69* Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81240925
70ErbB signaling pathway_Homo sapiens_hsa040120.81229855
71Fatty acid degradation_Homo sapiens_hsa000710.79812837
72PPAR signaling pathway_Homo sapiens_hsa033200.79291990
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79270166
74Morphine addiction_Homo sapiens_hsa050320.78523518
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76297851
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76222136
77Amphetamine addiction_Homo sapiens_hsa050310.75899159
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.74450863
79Cholinergic synapse_Homo sapiens_hsa047250.72901996
80Malaria_Homo sapiens_hsa051440.72214473
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72002350
82Estrogen signaling pathway_Homo sapiens_hsa049150.71311444
83Insulin secretion_Homo sapiens_hsa049110.70073395
84Phenylalanine metabolism_Homo sapiens_hsa003600.69784835
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.69370477
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67851833
87Pancreatic cancer_Homo sapiens_hsa052120.67024359
88Dopaminergic synapse_Homo sapiens_hsa047280.66810636
89Fatty acid biosynthesis_Homo sapiens_hsa000610.66170357
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66117964
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66111984
92Long-term depression_Homo sapiens_hsa047300.65843396
93Platelet activation_Homo sapiens_hsa046110.64883522
94Proteoglycans in cancer_Homo sapiens_hsa052050.64739564
95Chemical carcinogenesis_Homo sapiens_hsa052040.64579219
96Protein digestion and absorption_Homo sapiens_hsa049740.63899094
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62684936
98Oxytocin signaling pathway_Homo sapiens_hsa049210.62599427
99Calcium signaling pathway_Homo sapiens_hsa040200.62554606
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62160613
101Gap junction_Homo sapiens_hsa045400.61259741
102Sulfur relay system_Homo sapiens_hsa041220.61045968
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60905999
104Adherens junction_Homo sapiens_hsa045200.59994534
105Staphylococcus aureus infection_Homo sapiens_hsa051500.59884367
106Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58368952
107Prostate cancer_Homo sapiens_hsa052150.58190633
108Cocaine addiction_Homo sapiens_hsa050300.55914441
109Vibrio cholerae infection_Homo sapiens_hsa051100.55420373
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55355019
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55284774
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54246761
113Glucagon signaling pathway_Homo sapiens_hsa049220.51966200
114Carbon metabolism_Homo sapiens_hsa012000.51955276
115Selenocompound metabolism_Homo sapiens_hsa004500.51085418
116Dorso-ventral axis formation_Homo sapiens_hsa043200.50810423
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.49781344
118Type II diabetes mellitus_Homo sapiens_hsa049300.49625888
119Thyroid cancer_Homo sapiens_hsa052160.48759119
120Fatty acid elongation_Homo sapiens_hsa000620.48426487
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47922179
122Propanoate metabolism_Homo sapiens_hsa006400.47535431
123Thyroid hormone synthesis_Homo sapiens_hsa049180.47214348
124Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46796401
125MAPK signaling pathway_Homo sapiens_hsa040100.45821143
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.45555556
127Prion diseases_Homo sapiens_hsa050200.45355635
128Sphingolipid metabolism_Homo sapiens_hsa006000.44920006
129Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44633125
130N-Glycan biosynthesis_Homo sapiens_hsa005100.44410434
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44387594
132Collecting duct acid secretion_Homo sapiens_hsa049660.43969846
133Endocytosis_Homo sapiens_hsa041440.43801234
134cAMP signaling pathway_Homo sapiens_hsa040240.43762609
135Rap1 signaling pathway_Homo sapiens_hsa040150.43620029
136Gastric acid secretion_Homo sapiens_hsa049710.43535290
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41940681
138Endometrial cancer_Homo sapiens_hsa052130.41103499
139Renin secretion_Homo sapiens_hsa049240.40117054
140GnRH signaling pathway_Homo sapiens_hsa049120.39887057
141Fat digestion and absorption_Homo sapiens_hsa049750.39361560
142Retinol metabolism_Homo sapiens_hsa008300.39294286
143Neurotrophin signaling pathway_Homo sapiens_hsa047220.39268869
144AMPK signaling pathway_Homo sapiens_hsa041520.37653244
145Circadian rhythm_Homo sapiens_hsa047100.37585754
146Ras signaling pathway_Homo sapiens_hsa040140.36956375
147Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35717852
148Peroxisome_Homo sapiens_hsa041460.35643245
149Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34688036
150Colorectal cancer_Homo sapiens_hsa052100.34381104
151Vitamin B6 metabolism_Homo sapiens_hsa007500.32190659
152Arginine and proline metabolism_Homo sapiens_hsa003300.30619276

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