CHTF8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a short protein that forms part of the Ctf18 replication factor C (RFC) complex that occurs in both yeast and mammals. The heteroheptameric RFC complex plays a role in sister chromatid cohesion and may load the replication clamp PCNA (proliferating cell nuclear antigen) onto DNA during DNA replication and repair. This gene is ubiquitously expressed and has been shown to have reduced expression in renal and prostate tumors. Alternatively spliced transcript variants have been described. This gene has a pseudogene on chromosome X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.01996396
2folic acid-containing compound biosynthetic process (GO:0009396)4.42233735
3regulation of translational fidelity (GO:0006450)4.41451834
4protein localization to kinetochore (GO:0034501)3.99361757
5nuclear pore organization (GO:0006999)3.95242865
6nuclear pore complex assembly (GO:0051292)3.89650614
7pre-miRNA processing (GO:0031054)3.81441765
8negative regulation of erythrocyte differentiation (GO:0045647)3.74284947
9heterochromatin organization (GO:0070828)3.73339741
10protein localization to endosome (GO:0036010)3.72573229
11negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.68473074
12peptidyl-lysine dimethylation (GO:0018027)3.63377167
13regulation of translational termination (GO:0006449)3.61076521
14mitotic nuclear envelope disassembly (GO:0007077)3.57629149
15pentose-phosphate shunt (GO:0006098)3.57596987
16protein retention in ER lumen (GO:0006621)3.47513483
17retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.47395090
18dosage compensation (GO:0007549)3.45293953
19DNA duplex unwinding (GO:0032508)3.42993391
20negative regulation of RNA splicing (GO:0033119)3.40348244
21membrane disassembly (GO:0030397)3.40066776
22nuclear envelope disassembly (GO:0051081)3.40066776
23maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.38977668
24DNA geometric change (GO:0032392)3.38509500
25pinocytosis (GO:0006907)3.37839391
26DNA replication-dependent nucleosome assembly (GO:0006335)3.34732833
27DNA replication-dependent nucleosome organization (GO:0034723)3.34732833
28mRNA stabilization (GO:0048255)3.33434254
29RNA stabilization (GO:0043489)3.33434254
30protein localization to chromosome, centromeric region (GO:0071459)3.31881854
31proline biosynthetic process (GO:0006561)3.30512675
32maternal placenta development (GO:0001893)3.27538686
33positive regulation of Cdc42 GTPase activity (GO:0043089)3.22254965
34regulation of mammary gland epithelial cell proliferation (GO:0033599)3.21783307
35positive regulation of histone deacetylation (GO:0031065)3.21504411
36IMP biosynthetic process (GO:0006188)3.19688809
37barbed-end actin filament capping (GO:0051016)3.19134512
38regulation of early endosome to late endosome transport (GO:2000641)3.16981715
39antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.16394410
40antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.16394410
41chromatin assembly (GO:0031497)3.15127049
423-UTR-mediated mRNA stabilization (GO:0070935)3.15053198
43Golgi transport vesicle coating (GO:0048200)3.14445753
44COPI coating of Golgi vesicle (GO:0048205)3.14445753
45spliceosomal tri-snRNP complex assembly (GO:0000244)3.12346452
46negative regulation of histone methylation (GO:0031061)3.11599907
47glucose catabolic process (GO:0006007)3.11332065
48regulation of sister chromatid cohesion (GO:0007063)3.08357389
49mitotic chromosome condensation (GO:0007076)3.07785490
50NADPH regeneration (GO:0006740)3.06764371
51glucocorticoid receptor signaling pathway (GO:0042921)3.06705430
52negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.04497470
53mitotic G1 DNA damage checkpoint (GO:0031571)3.04093946
54translesion synthesis (GO:0019985)3.03942266
55activation of Rac GTPase activity (GO:0032863)3.02698827
56sister chromatid segregation (GO:0000819)3.02053601
57embryonic process involved in female pregnancy (GO:0060136)2.97265264
58negative regulation of mRNA processing (GO:0050686)2.96444350
59cell-substrate adherens junction assembly (GO:0007045)2.94657955
60focal adhesion assembly (GO:0048041)2.94657955
61mitotic sister chromatid cohesion (GO:0007064)2.93715348
62stress fiber assembly (GO:0043149)2.92556448
63negative regulation of cell size (GO:0045792)2.92552632
64DNA strand elongation involved in DNA replication (GO:0006271)2.91768579
65epithelial cell differentiation involved in prostate gland development (GO:0060742)2.90958818
66modulation by symbiont of host cellular process (GO:0044068)2.90782621
67negative regulation of mRNA metabolic process (GO:1903312)2.90257196
68positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.89903425
69peptidyl-arginine omega-N-methylation (GO:0035247)2.87386296
70nuclear envelope organization (GO:0006998)2.86598862
71regulation of histone H3-K9 methylation (GO:0051570)2.83075554
72NLS-bearing protein import into nucleus (GO:0006607)2.81448321
73regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.79495040
74glucose 6-phosphate metabolic process (GO:0051156)2.79326498
75regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.79295979
76IMP metabolic process (GO:0046040)2.76980516
77histone H2A monoubiquitination (GO:0035518)2.76334509
78positive regulation of SMAD protein import into nucleus (GO:0060391)2.74781347
79NIK/NF-kappaB signaling (GO:0038061)2.74601168
80cell-substrate junction assembly (GO:0007044)2.73760722
81regulation of protein heterodimerization activity (GO:0043497)2.73597886
82DNA strand elongation (GO:0022616)2.73225320
83regulation of RNA export from nucleus (GO:0046831)2.72052879
84establishment of apical/basal cell polarity (GO:0035089)2.71877459
85paraxial mesoderm development (GO:0048339)2.69146870
86regulation of posttranscriptional gene silencing (GO:0060147)2.69021144
87regulation of gene silencing by miRNA (GO:0060964)2.69021144
88regulation of gene silencing by RNA (GO:0060966)2.69021144
89T cell apoptotic process (GO:0070231)2.66587243
90modulation by virus of host process (GO:0019054)2.66464754
91pore complex assembly (GO:0046931)2.65284388
92cellular response to epidermal growth factor stimulus (GO:0071364)2.65211107
93viral transcription (GO:0019083)2.65138235
94cellular response to virus (GO:0098586)2.64367005
95response to laminar fluid shear stress (GO:0034616)2.64072005
96regulation of hippo signaling (GO:0035330)2.63582702
97alternative mRNA splicing, via spliceosome (GO:0000380)2.62065083
98antigen processing and presentation of endogenous antigen (GO:0019883)2.61522807
99mitotic sister chromatid segregation (GO:0000070)2.61157295
100tetrahydrofolate metabolic process (GO:0046653)2.60723543
101regulation of type I interferon-mediated signaling pathway (GO:0060338)2.60459491
102regulation of spindle organization (GO:0090224)2.60257572
103regulation of glucose import in response to insulin stimulus (GO:2001273)2.59209601
104apoptotic process involved in morphogenesis (GO:0060561)2.58790646
105regulation of defense response to virus by virus (GO:0050690)2.58574161
106translational termination (GO:0006415)2.57982169
107positive regulation of nuclease activity (GO:0032075)2.57851005
108positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.57112077
109formation of translation preinitiation complex (GO:0001731)2.55371987
110regulation of mRNA stability (GO:0043488)2.55317117
111mitotic G1/S transition checkpoint (GO:0044819)2.53851566
112DNA replication initiation (GO:0006270)2.53669226
113basement membrane organization (GO:0071711)2.53405390
114positive regulation by symbiont of host defense response (GO:0052509)2.53338068
115modulation by symbiont of host defense response (GO:0052031)2.53338068
116modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.53338068
117modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.53338068
118positive regulation by organism of defense response of other organism involved in symbiotic interact2.53338068
119modulation by symbiont of host immune response (GO:0052553)2.53338068
120embryonic foregut morphogenesis (GO:0048617)2.53145638
121intracellular estrogen receptor signaling pathway (GO:0030520)2.52636224
122DNA conformation change (GO:0071103)2.52315117
123regulation of chromatin binding (GO:0035561)2.51847634
124mannose metabolic process (GO:0006013)2.51637127
125nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.51484852
126translational elongation (GO:0006414)2.50824987
127peptidyl-arginine N-methylation (GO:0035246)2.49869814
128peptidyl-arginine methylation (GO:0018216)2.49869814
129activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.48735740
130regulation of SMAD protein import into nucleus (GO:0060390)2.48130150
131modulation by virus of host morphology or physiology (GO:0019048)2.47896590
132corticosteroid receptor signaling pathway (GO:0031958)2.47646550
133chromatin assembly or disassembly (GO:0006333)2.46965985
134positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.46429244
135regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.46429244
136response to UV-C (GO:0010225)2.46379758
137morphogenesis of an endothelium (GO:0003159)2.45870267
138endothelial tube morphogenesis (GO:0061154)2.45870267
139protein-DNA complex disassembly (GO:0032986)2.44535639
140nucleosome disassembly (GO:0006337)2.44535639
141positive regulation of RNA splicing (GO:0033120)2.44251056
142planar cell polarity pathway involved in neural tube closure (GO:0090179)2.43962756
143negative regulation of viral release from host cell (GO:1902187)2.42929522
144adherens junction assembly (GO:0034333)2.41484300
145vesicle coating (GO:0006901)2.36358129
146regulation of NFAT protein import into nucleus (GO:0051532)2.36157931
147endoplasmic reticulum unfolded protein response (GO:0030968)2.35849234
148regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.35648770
149regulation of nuclease activity (GO:0032069)2.35519977
150protein maturation by protein folding (GO:0022417)2.35345796
151amyloid precursor protein catabolic process (GO:0042987)2.35307191
152histone arginine methylation (GO:0034969)2.31026713
153hyaluronan catabolic process (GO:0030214)2.30411767
154response to peptidoglycan (GO:0032494)2.29555585
155regulation of cholesterol homeostasis (GO:2000188)2.27664730
156epithelial cell-cell adhesion (GO:0090136)2.27649383
157ER-nucleus signaling pathway (GO:0006984)2.27620384
158hemidesmosome assembly (GO:0031581)2.27471767
159regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.27325280
160activation of MAPKKK activity (GO:0000185)2.27093394
161cellular hyperosmotic response (GO:0071474)2.25989423
162NADH metabolic process (GO:0006734)2.24937307
163cellular response to interleukin-4 (GO:0071353)2.23801058
164detection of bacterium (GO:0016045)2.22440047
165trophectodermal cell differentiation (GO:0001829)2.22432783
166protein export from nucleus (GO:0006611)2.20180272
167cytoskeletal anchoring at plasma membrane (GO:0007016)2.18840018
168response to muramyl dipeptide (GO:0032495)2.17047260
169cellular response to unfolded protein (GO:0034620)2.16515470
170detection of other organism (GO:0098543)2.16043303

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.19031624
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.30329798
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.78243999
4MYC_22102868_ChIP-Seq_BL_Human3.49369834
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.20476587
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.15613087
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.57731463
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.42482740
9VDR_21846776_ChIP-Seq_THP-1_Human2.35750511
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.13615097
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.09019001
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.06220811
13TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99264690
14TCF7_22412390_ChIP-Seq_EML_Mouse1.88535129
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.79935180
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.79640625
17AR_21909140_ChIP-Seq_LNCAP_Human1.79399356
18ELK3_25401928_ChIP-Seq_HUVEC_Human1.78170558
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.77016384
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.73875995
21KDM2B_26808549_Chip-Seq_DND41_Human1.73092077
22CLOCK_20551151_ChIP-Seq_293T_Human1.67479546
23KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.66623959
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.62219916
25XRN2_22483619_ChIP-Seq_HELA_Human1.61423952
26E2F1_21310950_ChIP-Seq_MCF-7_Human1.60445980
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.56985749
28CIITA_25753668_ChIP-Seq_RAJI_Human1.56145464
29MYC_19030024_ChIP-ChIP_MESCs_Mouse1.54629182
30ZNF263_19887448_ChIP-Seq_K562_Human1.54249584
31MAF_26560356_Chip-Seq_TH1_Human1.54082022
32UTX_26944678_Chip-Seq_JUKART_Human1.49705268
33* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.47802307
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47399391
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.44947514
36ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44837952
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.43342981
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.43119681
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37293601
40STAT3_1855785_ChIP-Seq_MESCs_Mouse1.36478128
41ESR1_15608294_ChIP-ChIP_MCF-7_Human1.35900319
42POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.35581037
43SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.35055071
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34721484
45CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34400178
46DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.33490539
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.32683199
48CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.32402393
49ATF3_27146783_Chip-Seq_COLON_Human1.31776007
50* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.31701953
51TET1_21451524_ChIP-Seq_MESCs_Mouse1.29424664
52LXR_22292898_ChIP-Seq_THP-1_Human1.29135677
53NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28970689
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28922439
55KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28891854
56ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.28154893
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25469792
58KDM5A_27292631_Chip-Seq_BREAST_Human1.24298097
59P68_20966046_ChIP-Seq_HELA_Human1.23279874
60BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22934046
61CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21217271
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20623559
63KDM2B_26808549_Chip-Seq_K562_Human1.20466762
64RACK7_27058665_Chip-Seq_MCF-7_Human1.19903344
65P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19427427
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18358479
67* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18096676
68HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17997482
69NCOR1_26117541_ChIP-Seq_K562_Human1.17756615
70HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17678621
71RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17104229
72SA1_27219007_Chip-Seq_ERYTHROID_Human1.16383663
73VDR_24763502_ChIP-Seq_THP-1_Human1.15478571
74MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14579587
75RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13372637
76ZFP281_27345836_Chip-Seq_ESCs_Mouse1.13278666
77TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12042588
78MYCN_18555785_ChIP-Seq_MESCs_Mouse1.11999825
79EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11161077
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10606187
81TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10498545
82NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10269014
83RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09312540
84KDM2B_26808549_Chip-Seq_JURKAT_Human1.08657499
85CHD1_26751641_Chip-Seq_LNCaP_Human1.08215357
86SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08117142
87TFEB_21752829_ChIP-Seq_HELA_Human1.06577404
88E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06559302
89NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.05823647
90SMC4_20622854_ChIP-Seq_HELA_Human1.05577296
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05407528
92TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05242583
93EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05132584
94TP53_22127205_ChIP-Seq_IMR90_Human1.05126532
95PPARA_22158963_ChIP-Seq_LIVER_Mouse1.04361702
96RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04026925
97MYB_26560356_Chip-Seq_TH2_Human1.03864158
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03774450
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03025814
100WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02929766
101ESR2_21235772_ChIP-Seq_MCF-7_Human1.02359840
102NANOG_21062744_ChIP-ChIP_HESCs_Human1.02268048
103STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02130981
104MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.01366698
105MAF_26560356_Chip-Seq_TH2_Human1.01285647
106MYB_26560356_Chip-Seq_TH1_Human1.01203140
107STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.01145506
108ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00691819
109POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99880969
110SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99741093
111CREB1_26743006_Chip-Seq_LNCaP_Human0.99385302
112STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98975537
113ELF1_20517297_ChIP-Seq_JURKAT_Human0.98585402
114ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98522206
115SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98104963
116DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98050309
117RUNX1_22412390_ChIP-Seq_EML_Mouse0.97505282
118NANOG_18555785_ChIP-Seq_MESCs_Mouse0.96228068
119SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96118024
120FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.95532862
121MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94822184
122SCL_19346495_ChIP-Seq_HPC-7_Human0.94111562
123SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91962433
124TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90362593
125* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.89501051
126GATA6_25053715_ChIP-Seq_YYC3_Human0.86550346
127GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86416509
128GABP_19822575_ChIP-Seq_HepG2_Human0.85376794
129E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85345698
130CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84927089

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.79497308
2MP0010352_gastrointestinal_tract_polyps3.39054206
3MP0005451_abnormal_body_composition3.14972358
4MP0005058_abnormal_lysosome_morphology2.95947162
5MP0005076_abnormal_cell_differentiation2.68739410
6MP0003300_gastrointestinal_ulcer2.49702023
7MP0008260_abnormal_autophagy2.45620328
8MP0010234_abnormal_vibrissa_follicle2.38692222
9MP0010307_abnormal_tumor_latency2.30572028
10MP0003111_abnormal_nucleus_morphology2.26371436
11MP0003191_abnormal_cellular_cholesterol2.19337999
12MP0003436_decreased_susceptibility_to2.15075281
13MP0000537_abnormal_urethra_morphology2.14032209
14MP0004957_abnormal_blastocyst_morpholog2.13809057
15MP0006054_spinal_hemorrhage2.11328975
16MP0003077_abnormal_cell_cycle2.08755584
17MP0010094_abnormal_chromosome_stability2.06760138
18MP0003693_abnormal_embryo_hatching2.00704506
19MP0002396_abnormal_hematopoietic_system2.00003647
20MP0001730_embryonic_growth_arrest1.97331257
21MP0003566_abnormal_cell_adhesion1.92473577
22MP0004858_abnormal_nervous_system1.90748460
23MP0009278_abnormal_bone_marrow1.83825165
24MP0002796_impaired_skin_barrier1.80420864
25MP0004808_abnormal_hematopoietic_stem1.78919636
26MP0009053_abnormal_anal_canal1.78659122
27MP0004197_abnormal_fetal_growth/weight/1.77333688
28MP0000350_abnormal_cell_proliferation1.77017216
29MP0005257_abnormal_intraocular_pressure1.73592223
30MP0002877_abnormal_melanocyte_morpholog1.72855536
31MP0001849_ear_inflammation1.65414315
32MP0003123_paternal_imprinting1.61818660
33MP0003283_abnormal_digestive_organ1.61270137
34MP0000733_abnormal_muscle_development1.58160310
35MP0003303_peritoneal_inflammation1.56795483
36MP0001672_abnormal_embryogenesis/_devel1.53373789
37MP0005380_embryogenesis_phenotype1.53373789
38MP0003984_embryonic_growth_retardation1.51358329
39MP0008007_abnormal_cellular_replicative1.51236473
40MP0005023_abnormal_wound_healing1.50641688
41MP0002088_abnormal_embryonic_growth/wei1.50093487
42MP0002086_abnormal_extraembryonic_tissu1.49091259
43MP0002084_abnormal_developmental_patter1.48757327
44MP0005501_abnormal_skin_physiology1.44841254
45MP0005464_abnormal_platelet_physiology1.44570698
46MP0001697_abnormal_embryo_size1.44241971
47MP0008438_abnormal_cutaneous_collagen1.39583667
48MP0002080_prenatal_lethality1.38814058
49MP0002085_abnormal_embryonic_tissue1.36520252
50MP0009840_abnormal_foam_cell1.36228865
51MP0000490_abnormal_crypts_of1.33030160
52MP0010030_abnormal_orbit_morphology1.31983700
53MP0008961_abnormal_basal_metabolism1.26734682
54MP0001348_abnormal_lacrimal_gland1.26733605
55MP0001835_abnormal_antigen_presentation1.25689272
56MP0003567_abnormal_fetal_cardiomyocyte1.24382504
57MP0004185_abnormal_adipocyte_glucose1.24379498
58MP0003115_abnormal_respiratory_system1.21175944
59MP0003172_abnormal_lysosome_physiology1.20264009
60MP0005397_hematopoietic_system_phenotyp1.16745844
61MP0001545_abnormal_hematopoietic_system1.16745844
62MP0005025_abnormal_response_to1.15868406
63MP0005409_darkened_coat_color1.13785180
64MP0001915_intracranial_hemorrhage1.13697725
65MP0008057_abnormal_DNA_replication1.13568421
66MP0004272_abnormal_basement_membrane1.13354112
67MP0000428_abnormal_craniofacial_morphol1.11382572
68MP0009672_abnormal_birth_weight1.11013442
69MP0000703_abnormal_thymus_morphology1.09974631
70MP0002419_abnormal_innate_immunity1.09200084
71MP0002019_abnormal_tumor_incidence1.09064625
72MP0001216_abnormal_epidermal_layer1.08742342
73MP0005387_immune_system_phenotype1.08414192
74MP0001790_abnormal_immune_system1.08414192
75MP0005000_abnormal_immune_tolerance1.08233168
76MP0000685_abnormal_immune_system1.07387797
77MP0003091_abnormal_cell_migration1.06581496
78MP0002060_abnormal_skin_morphology1.04856149
79MP0002092_abnormal_eye_morphology1.04524674
80MP0000678_abnormal_parathyroid_gland1.04016439
81MP0002166_altered_tumor_susceptibility1.03904836
82MP0001533_abnormal_skeleton_physiology1.03357406
83MP0003119_abnormal_digestive_system1.00775789
84MP0004264_abnormal_extraembryonic_tissu1.00684222
85MP0004233_abnormal_muscle_weight1.00594234
86MP0002452_abnormal_antigen_presenting0.95000220
87MP0001800_abnormal_humoral_immune0.94657721
88MP0000477_abnormal_intestine_morphology0.93592090
89MP0002398_abnormal_bone_marrow0.93157489
90MP0000858_altered_metastatic_potential0.93142030
91MP0001819_abnormal_immune_cell0.93076951
92MP0002420_abnormal_adaptive_immunity0.92742653
93MP0002925_abnormal_cardiovascular_devel0.92115458
94MP0005666_abnormal_adipose_tissue0.91993826
95MP0003329_amyloid_beta_deposits0.90793235
96MP0001293_anophthalmia0.90252620
97MP0009931_abnormal_skin_appearance0.89811934
98MP0000003_abnormal_adipose_tissue0.89663966
99MP0000313_abnormal_cell_death0.89626517
100MP0003221_abnormal_cardiomyocyte_apopto0.89626109
101MP0009703_decreased_birth_body0.88675283
102MP0003763_abnormal_thymus_physiology0.88334263
103MP0002722_abnormal_immune_system0.87787964
104MP0002723_abnormal_immune_serum0.87675634
105MP0002089_abnormal_postnatal_growth/wei0.87093917
106MP0008932_abnormal_embryonic_tissue0.87080317
107MP0010630_abnormal_cardiac_muscle0.86305654
108MP0009333_abnormal_splenocyte_physiolog0.85550607
109MP0004947_skin_inflammation0.85310386
110MP0003279_aneurysm0.84261864
111MP0008004_abnormal_stomach_pH0.83952211
112MP0005623_abnormal_meninges_morphology0.83610331
113MP0002111_abnormal_tail_morphology0.82893357
114MP0000716_abnormal_immune_system0.82637590
115MP0002697_abnormal_eye_size0.82117116
116MP0003890_abnormal_embryonic-extraembry0.82050095
117MP0004782_abnormal_surfactant_physiolog0.81001584
118MP0003828_pulmonary_edema0.80536334
119MP0000465_gastrointestinal_hemorrhage0.80498182
120MP0002998_abnormal_bone_remodeling0.80290439
121MP0008770_decreased_survivor_rate0.79014415
122MP0000598_abnormal_liver_morphology0.78602113
123MP0003075_altered_response_to0.78400655
124MP0000689_abnormal_spleen_morphology0.78023405
125MP0002405_respiratory_system_inflammati0.77938762
126MP0001851_eye_inflammation0.76290082
127MP0001853_heart_inflammation0.75966562
128MP0005621_abnormal_cell_physiology0.75152016
129MP0003121_genomic_imprinting0.74994471
130MP0000266_abnormal_heart_morphology0.74419768
131MP0005375_adipose_tissue_phenotype0.73588187
132MP0002932_abnormal_joint_morphology0.72194004
133MP0002234_abnormal_pharynx_morphology0.71407410
134MP0005275_abnormal_skin_tensile0.70676843
135MP0003453_abnormal_keratinocyte_physiol0.70078049
136MP0000534_abnormal_ureter_morphology0.70063206
137MP0001958_emphysema0.69437865
138MP0003935_abnormal_craniofacial_develop0.69206585
139MP0000609_abnormal_liver_physiology0.68828901
140MP0002429_abnormal_blood_cell0.68802863
141MP0010155_abnormal_intestine_physiology0.67874989
142MP0005384_cellular_phenotype0.65284095

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.47316737
2Protrusio acetabuli (HP:0003179)3.28067875
3Ependymoma (HP:0002888)3.16764113
4Cerebral aneurysm (HP:0004944)3.13417162
5Short 4th metacarpal (HP:0010044)3.12461542
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.12461542
7Vertebral compression fractures (HP:0002953)2.97562972
8Increased density of long bones (HP:0006392)2.75057963
9Shallow orbits (HP:0000586)2.70684605
10Abnormality of the 4th metacarpal (HP:0010012)2.62766165
11Renal duplication (HP:0000075)2.61309561
12Ankle contracture (HP:0006466)2.60324055
13Cellulitis (HP:0100658)2.56199351
14Centrally nucleated skeletal muscle fibers (HP:0003687)2.56043103
15Spastic diplegia (HP:0001264)2.52672389
16Abnormality of the astrocytes (HP:0100707)2.51908697
17Astrocytoma (HP:0009592)2.51908697
18Ulnar bowing (HP:0003031)2.50447771
19Eczematoid dermatitis (HP:0000976)2.49576428
20Increased nuchal translucency (HP:0010880)2.47991931
21Elfin facies (HP:0004428)2.44110394
22Selective tooth agenesis (HP:0001592)2.40945752
23Bowel diverticulosis (HP:0005222)2.40722253
24Subacute progressive viral hepatitis (HP:0006572)2.39060766
25Aortic aneurysm (HP:0004942)2.38443955
26Renovascular hypertension (HP:0100817)2.33520151
27Deviation of the thumb (HP:0009603)2.31843395
28Pseudobulbar signs (HP:0002200)2.31623404
29Long palpebral fissure (HP:0000637)2.31307552
30Flat acetabular roof (HP:0003180)2.30775714
31Distal lower limb amyotrophy (HP:0008944)2.30265277
32Medulloblastoma (HP:0002885)2.26801642
33Basal cell carcinoma (HP:0002671)2.26727495
34Hand muscle atrophy (HP:0009130)2.25094347
35Proximal placement of thumb (HP:0009623)2.24852297
36Cholecystitis (HP:0001082)2.24518199
37Abnormal gallbladder physiology (HP:0012438)2.24518199
38Increased connective tissue (HP:0009025)2.23477951
39Hemorrhage of the eye (HP:0011885)2.23437473
40Broad face (HP:0000283)2.22210815
41Colon cancer (HP:0003003)2.22020025
42Mitral valve prolapse (HP:0001634)2.21635249
43Abnormality of the thoracic spine (HP:0100711)2.20480990
44Dilatation of the ascending aorta (HP:0005111)2.19008923
45Rectal prolapse (HP:0002035)2.17612045
46Upper limb amyotrophy (HP:0009129)2.16987383
47Distal upper limb amyotrophy (HP:0007149)2.16987383
48Cutaneous melanoma (HP:0012056)2.15066940
49Disproportionate tall stature (HP:0001519)2.12987078
50Lymphangioma (HP:0100764)2.12332524
51Thoracic kyphosis (HP:0002942)2.09112080
52Increased IgE level (HP:0003212)2.08953457
53Abnormality of oral frenula (HP:0000190)2.08476665
54Enlarged penis (HP:0000040)2.08392894
55Aneurysm (HP:0002617)2.07582649
56High pitched voice (HP:0001620)2.07306492
57Gastrointestinal carcinoma (HP:0002672)2.06830856
58Malignant gastrointestinal tract tumors (HP:0006749)2.06830856
59Short nail (HP:0001799)2.06057476
60Insomnia (HP:0100785)2.02489154
61Pointed chin (HP:0000307)2.02019799
62Distal lower limb muscle weakness (HP:0009053)2.01702275
63Genu recurvatum (HP:0002816)2.01340719
64Fibroma (HP:0010614)2.01076163
65Asymmetry of the thorax (HP:0001555)2.00990814
66Radial bowing (HP:0002986)2.00672325
67Adenoma sebaceum (HP:0009720)2.00240137
68Angiofibromas (HP:0010615)2.00240137
69Overriding aorta (HP:0002623)1.99539854
70Ankyloglossia (HP:0010296)1.99445845
71Hypertensive crisis (HP:0100735)1.99444375
72Fibrous tissue neoplasm (HP:0012316)1.98865891
73Bladder diverticulum (HP:0000015)1.97885577
74Abnormality of macrophages (HP:0004311)1.96913658
75Bicuspid aortic valve (HP:0001647)1.96472928
76Reticulocytosis (HP:0001923)1.95555956
77Hallux valgus (HP:0001822)1.94845247
78Glioma (HP:0009733)1.94155155
79Abnormality of the distal phalanges of the toes (HP:0010182)1.93933597
80Abnormality of the calcaneus (HP:0008364)1.93322062
81Biliary tract neoplasm (HP:0100574)1.92747689
82Deviation of the hallux (HP:0010051)1.92220602
83Polygenic inheritance (HP:0010982)1.89610697
84Hyperparathyroidism (HP:0000843)1.86860900
85Thrombocytosis (HP:0001894)1.86146100
86Cervical subluxation (HP:0003308)1.84664546
87Bowed forearm bones (HP:0003956)1.84563422
88Bowing of the arm (HP:0006488)1.84563422
89Trismus (HP:0000211)1.84028377
90Abnormality of the peritoneum (HP:0002585)1.83849632
91Progressive muscle weakness (HP:0003323)1.83725689
92Loss of speech (HP:0002371)1.83491614
93Colitis (HP:0002583)1.82978234
94Heterotopia (HP:0002282)1.82238706
95Neoplasm of striated muscle (HP:0009728)1.81402217
96Back pain (HP:0003418)1.80914755
97Progressive external ophthalmoplegia (HP:0000590)1.80535013
98Skin tags (HP:0010609)1.80441700
99Gastrointestinal stroma tumor (HP:0100723)1.80201960
100Abnormality of the fingertips (HP:0001211)1.79715723
101Long toe (HP:0010511)1.79353006
102Broad palm (HP:0001169)1.79339060
103Ragged-red muscle fibers (HP:0003200)1.79103651
104Abnormality of liposaccharide metabolism (HP:0010968)1.77867510
105Abnormality of glycosphingolipid metabolism (HP:0004343)1.77867510
106Abnormality of glycolipid metabolism (HP:0010969)1.77867510
107Segmental peripheral demyelination/remyelination (HP:0003481)1.76944544
108Interstitial pulmonary disease (HP:0006530)1.76891964
109Dysostosis multiplex (HP:0000943)1.75942457
110Thin bony cortex (HP:0002753)1.75314597
111Increased cerebral lipofuscin (HP:0011813)1.74847397
112Gastrointestinal inflammation (HP:0004386)1.74350497
113Rhabdomyosarcoma (HP:0002859)1.74098866
114Multiple enchondromatosis (HP:0005701)1.73917643
115Intestinal polyp (HP:0005266)1.73539852
116Spinal cord lesions (HP:0100561)1.73386564
117Syringomyelia (HP:0003396)1.73386564
118Increased variability in muscle fiber diameter (HP:0003557)1.73322737
119Macroorchidism (HP:0000053)1.72282399
120Deep venous thrombosis (HP:0002625)1.72274341
121Purpura (HP:0000979)1.71568988
122Orthostatic hypotension (HP:0001278)1.70903529
123Abnormality of skeletal muscle fiber size (HP:0012084)1.70491076
124Blue sclerae (HP:0000592)1.69817698
125Natal tooth (HP:0000695)1.68232739
126Osteolytic defects of the hand bones (HP:0009699)1.68097343
127Osteolytic defects of the phalanges of the hand (HP:0009771)1.68097343
128Fragile skin (HP:0001030)1.67841047
129Abnormal platelet volume (HP:0011876)1.67516896
130Broad thumb (HP:0011304)1.66710971
131Abnormality of the distal phalanx of the thumb (HP:0009617)1.65541678
132Recurrent abscess formation (HP:0002722)1.65362773
133Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.64690389
134Persistence of primary teeth (HP:0006335)1.64213210
135Intestinal polyposis (HP:0200008)1.64168241
136Premature rupture of membranes (HP:0001788)1.63898528
137Long eyelashes (HP:0000527)1.63640728
138Achilles tendon contracture (HP:0001771)1.63516597
139Trigonocephaly (HP:0000243)1.63307581
140Fatigue (HP:0012378)1.62544208
141Spinal rigidity (HP:0003306)1.61878751
142Abnormality of the lower motor neuron (HP:0002366)1.61672008
143Biconcave vertebral bodies (HP:0004586)1.61526399
144Hematochezia (HP:0002573)1.61410477
145Severe short stature (HP:0003510)1.60896530
146Advanced eruption of teeth (HP:0006288)1.60255074
147Recurrent viral infections (HP:0004429)1.60148270
148Missing ribs (HP:0000921)1.60040062
149Papilloma (HP:0012740)1.59597901
150Verrucae (HP:0200043)1.59597901
151Cutis marmorata (HP:0000965)1.59513902
152Ridged nail (HP:0001807)1.59361604
153Viral hepatitis (HP:0006562)1.59063283
154Bone pain (HP:0002653)1.59036558
155Abnormality of the Achilles tendon (HP:0005109)1.59022149
156Prominent nose (HP:0000448)1.58884567
157Emphysema (HP:0002097)1.58725737
158Sandal gap (HP:0001852)1.57950230
159Flat cornea (HP:0007720)1.57456687
160Mitral regurgitation (HP:0001653)1.57244541
161Striae distensae (HP:0001065)1.57203438
162Abnormal ossification of hand bones (HP:0005921)1.56604362
163Upper motor neuron abnormality (HP:0002127)1.56472670
164Metaphyseal cupping (HP:0003021)1.56219143
165Chronic obstructive pulmonary disease (HP:0006510)1.55724186
166Obstructive lung disease (HP:0006536)1.55724186
167Aortic dissection (HP:0002647)1.55575192
168Uterine neoplasm (HP:0010784)1.55537768
169Micronodular cirrhosis (HP:0001413)1.55494278
170Neoplasm of the oral cavity (HP:0100649)1.54520340
171Patellar dislocation (HP:0002999)1.54161575
172Polycythemia (HP:0001901)1.53944460
173Neuronal loss in central nervous system (HP:0002529)1.51739189
174Myocardial infarction (HP:0001658)1.51123304
175Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.50297270
176Gingivitis (HP:0000230)1.49783880
177Atrophic scars (HP:0001075)1.49627867

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.69846912
2TRIB34.47984167
3PKN24.01904954
4SMG13.86106757
5MAP3K103.64626635
6PRPF4B3.25961068
7CDK122.51066448
8IRAK32.32896646
9SCYL22.18409572
10NEK22.09193775
11CDC72.05913881
12ERN12.01177340
13NME22.00905475
14TTN1.96038035
15LRRK21.93913272
16PTK61.85822646
17NEK11.85506853
18RPS6KB21.82686520
19PASK1.75201639
20PAK41.63481215
21ARAF1.62265181
22PDGFRA1.61967199
23SIK11.58139901
24FLT31.55932923
25TAOK21.53392514
26STK101.53123787
27ALK1.48359325
28MAP3K131.47856822
29RIPK11.47513881
30CDK41.44848522
31MAP4K11.44564394
32CDK61.39530563
33MAP3K81.33087448
34TGFBR11.29220900
35MTOR1.24393812
36FGFR41.16916558
37PIM21.15875600
38RIPK41.13689098
39MST1R1.13405004
40RPS6KA41.13144052
41WEE11.12391580
42LATS11.12306058
43ICK1.11838370
44GRK61.09781056
45MAP3K141.06819641
46BMX1.06047142
47TESK21.05718488
48PAK21.03491264
49MAP3K30.99903083
50MAP2K30.98296840
51TSSK60.97117367
52CAMK1D0.94117805
53TBK10.93554595
54MAP3K10.90221186
55MAPKAPK30.89436719
56TTK0.88950640
57SIK30.86522622
58CDC42BPA0.84213096
59FGFR10.83466535
60ATR0.82165704
61IRAK40.81646604
62CDK70.81089026
63BUB10.80212229
64MAP3K90.78429610
65BRAF0.77725914
66EPHA20.76922822
67LMTK20.73307979
68STK40.72409123
69CHEK10.71828146
70AURKB0.71777113
71TAOK10.71694539
72FGFR30.71299394
73STK30.71067801
74ILK0.70704431
75PRKD20.70485743
76RET0.69123518
77MARK20.67412636
78PDPK10.67040277
79TESK10.66846114
80ZAP700.66185310
81JAK30.66062480
82LATS20.65599550
83KSR20.64380276
84PTK20.64115237
85KSR10.62270011
86BRD40.61868629
87BTK0.60880921
88PDGFRB0.60478122
89CSK0.60447758
90RPS6KA20.59942042
91PRKD30.59553126
92CSF1R0.58516941
93NTRK10.58272726
94PIM10.57304780
95DDR20.56430214
96MOS0.56024181
97TYRO30.54624258
98MET0.53917414
99CAMK1G0.53702913
100MAP3K70.53695958
101IRAK20.52602535
102TGFBR20.52364462
103CDK20.51039414
104MAP3K60.51032766
105CDK90.50947377
106DYRK1B0.50345789
107SIK20.50301291
108RAF10.49523322
109CDK80.49037624
110DYRK30.48985464
111PLK10.48630246
112HIPK20.48318712
113MAP2K20.46961646
114RPS6KL10.46916953
115RPS6KC10.46916953
116MAPK110.46581292
117AKT20.46486851
118CLK10.45735359
119FGR0.44434086
120NEK90.42074107
121KDR0.41691619
122ITK0.41510116
123TYK20.41244045
124AURKA0.40380762
125EPHB20.39320936
126ERBB20.38901401
127FGFR20.38606617
128VRK20.38435468
129RPS6KA10.37406949
130JAK20.37235542
131ATM0.36854571
132MAPKAPK20.35623245
133HCK0.35568825
134ACVR1B0.34830276
135DMPK0.34268078
136EPHB10.33532457
137PAK10.33495681
138BRSK20.33058504
139CHEK20.32864754
140PDK10.32004218
141CDK11A0.31905376
142BRSK10.31848110
143PRKG20.31847053
144LIMK10.31738099
145CDK140.31489671
146MAP3K110.31233439
147BCKDK0.30983454
148BLK0.30817528
149CHUK0.30784321
150CDK150.29579588

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.93056039
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.58321837
3One carbon pool by folate_Homo sapiens_hsa006702.42133153
4Other glycan degradation_Homo sapiens_hsa005112.41395042
5Chronic myeloid leukemia_Homo sapiens_hsa052202.06148896
6Mismatch repair_Homo sapiens_hsa034302.01877880
7Cell cycle_Homo sapiens_hsa041101.84123627
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.80780496
9RNA transport_Homo sapiens_hsa030131.75178030
10Spliceosome_Homo sapiens_hsa030401.71895625
11Viral carcinogenesis_Homo sapiens_hsa052031.54905284
12Small cell lung cancer_Homo sapiens_hsa052221.53912419
13Systemic lupus erythematosus_Homo sapiens_hsa053221.52277817
14Fructose and mannose metabolism_Homo sapiens_hsa000511.50795873
15Central carbon metabolism in cancer_Homo sapiens_hsa052301.50417744
16Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.49856724
17Base excision repair_Homo sapiens_hsa034101.49434164
18Selenocompound metabolism_Homo sapiens_hsa004501.47313121
19Biosynthesis of amino acids_Homo sapiens_hsa012301.44975172
20mTOR signaling pathway_Homo sapiens_hsa041501.44723911
21Lysine degradation_Homo sapiens_hsa003101.44127771
22Nitrogen metabolism_Homo sapiens_hsa009101.43670514
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.41876896
24MicroRNAs in cancer_Homo sapiens_hsa052061.41300146
25Bladder cancer_Homo sapiens_hsa052191.39597689
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.37626789
27Galactose metabolism_Homo sapiens_hsa000521.34854773
28Non-small cell lung cancer_Homo sapiens_hsa052231.33748131
29mRNA surveillance pathway_Homo sapiens_hsa030151.30737736
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.25970658
31HTLV-I infection_Homo sapiens_hsa051661.24757703
32Proteoglycans in cancer_Homo sapiens_hsa052051.24518697
33Colorectal cancer_Homo sapiens_hsa052101.24329812
34Leishmaniasis_Homo sapiens_hsa051401.22549036
35Notch signaling pathway_Homo sapiens_hsa043301.22251193
36Antigen processing and presentation_Homo sapiens_hsa046121.21703000
37Hepatitis C_Homo sapiens_hsa051601.21056995
38Prion diseases_Homo sapiens_hsa050201.20035720
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.19663641
40Influenza A_Homo sapiens_hsa051641.19206386
41Adherens junction_Homo sapiens_hsa045201.15646511
42Pancreatic cancer_Homo sapiens_hsa052121.14385594
43Acute myeloid leukemia_Homo sapiens_hsa052211.14191914
44p53 signaling pathway_Homo sapiens_hsa041151.11949390
45Thyroid cancer_Homo sapiens_hsa052161.11786340
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.10599595
47Endometrial cancer_Homo sapiens_hsa052131.10445114
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.09909904
49Pentose phosphate pathway_Homo sapiens_hsa000301.05377997
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.02148367
51Focal adhesion_Homo sapiens_hsa045101.01957752
52Neurotrophin signaling pathway_Homo sapiens_hsa047221.01534138
53Viral myocarditis_Homo sapiens_hsa054161.01024538
54Basal cell carcinoma_Homo sapiens_hsa052171.00396613
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.00023399
56Carbon metabolism_Homo sapiens_hsa012000.98439309
57Hippo signaling pathway_Homo sapiens_hsa043900.97605149
58B cell receptor signaling pathway_Homo sapiens_hsa046620.95989806
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95638918
60Salmonella infection_Homo sapiens_hsa051320.95538678
61Insulin resistance_Homo sapiens_hsa049310.95150106
62Lysosome_Homo sapiens_hsa041420.94796594
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.92208176
64Nucleotide excision repair_Homo sapiens_hsa034200.92073689
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.91177466
66Hepatitis B_Homo sapiens_hsa051610.90667013
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90105134
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89043940
69Measles_Homo sapiens_hsa051620.88918131
70Glioma_Homo sapiens_hsa052140.88598087
71Apoptosis_Homo sapiens_hsa042100.88596472
72VEGF signaling pathway_Homo sapiens_hsa043700.87294939
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87169607
74Tuberculosis_Homo sapiens_hsa051520.85892403
75ErbB signaling pathway_Homo sapiens_hsa040120.85143196
76Endocytosis_Homo sapiens_hsa041440.84426073
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84424103
78Shigellosis_Homo sapiens_hsa051310.81531269
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81479226
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81421526
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79710256
82AMPK signaling pathway_Homo sapiens_hsa041520.78985943
83TNF signaling pathway_Homo sapiens_hsa046680.78610951
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77864382
85HIF-1 signaling pathway_Homo sapiens_hsa040660.77320144
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76307877
87Vibrio cholerae infection_Homo sapiens_hsa051100.73305361
88Toxoplasmosis_Homo sapiens_hsa051450.72475313
89Insulin signaling pathway_Homo sapiens_hsa049100.71283221
90N-Glycan biosynthesis_Homo sapiens_hsa005100.69024101
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68031890
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68008441
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67542882
94Herpes simplex infection_Homo sapiens_hsa051680.67439352
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.67289462
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66810481
97Renal cell carcinoma_Homo sapiens_hsa052110.66183900
98Legionellosis_Homo sapiens_hsa051340.66134768
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65916049
100Epstein-Barr virus infection_Homo sapiens_hsa051690.65132998
101Sulfur relay system_Homo sapiens_hsa041220.65108737
102Pathways in cancer_Homo sapiens_hsa052000.64552554
103Prostate cancer_Homo sapiens_hsa052150.61997330
104T cell receptor signaling pathway_Homo sapiens_hsa046600.61534754
105Ribosome_Homo sapiens_hsa030100.61395491
106Alcoholism_Homo sapiens_hsa050340.59626060
107Platelet activation_Homo sapiens_hsa046110.59194865
108Phagosome_Homo sapiens_hsa041450.58974128
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.58438059
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58171229
111Arginine biosynthesis_Homo sapiens_hsa002200.58062459
112Prolactin signaling pathway_Homo sapiens_hsa049170.57864929
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.57857747
114Phenylalanine metabolism_Homo sapiens_hsa003600.57447044
115Staphylococcus aureus infection_Homo sapiens_hsa051500.55693978
116Choline metabolism in cancer_Homo sapiens_hsa052310.55416957
117Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55110941
118Amoebiasis_Homo sapiens_hsa051460.55045118
119Pertussis_Homo sapiens_hsa051330.55043718
120Oocyte meiosis_Homo sapiens_hsa041140.54872449
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54775823
122Primary immunodeficiency_Homo sapiens_hsa053400.54538187
123Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53518682
124TGF-beta signaling pathway_Homo sapiens_hsa043500.53009374
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52690494
126Drug metabolism - other enzymes_Homo sapiens_hsa009830.51513269
127Chemokine signaling pathway_Homo sapiens_hsa040620.51473162
128Hedgehog signaling pathway_Homo sapiens_hsa043400.51450191
129FoxO signaling pathway_Homo sapiens_hsa040680.51413472
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.51254575
131ECM-receptor interaction_Homo sapiens_hsa045120.51247135
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50926963
133Osteoclast differentiation_Homo sapiens_hsa043800.50260777

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »