CHUK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)7.59368764
2L-phenylalanine catabolic process (GO:0006559)7.10943141
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.10943141
4nuclear pore organization (GO:0006999)6.81526157
5L-phenylalanine metabolic process (GO:0006558)6.59446311
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.59446311
7aromatic amino acid family catabolic process (GO:0009074)6.48298754
8indole-containing compound catabolic process (GO:0042436)5.92839407
9indolalkylamine catabolic process (GO:0046218)5.92839407
10tryptophan catabolic process (GO:0006569)5.92839407
11cysteine metabolic process (GO:0006534)5.73435926
12tryptophan metabolic process (GO:0006568)5.65141497
13pore complex assembly (GO:0046931)5.59065054
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.55722784
15kynurenine metabolic process (GO:0070189)5.55139814
16glyoxylate metabolic process (GO:0046487)5.49119079
17bile acid biosynthetic process (GO:0006699)5.48646248
18mitotic sister chromatid cohesion (GO:0007064)5.25312455
19urea cycle (GO:0000050)5.11743957
20urea metabolic process (GO:0019627)5.11743957
21alpha-linolenic acid metabolic process (GO:0036109)5.09491310
22homocysteine metabolic process (GO:0050667)5.05361576
23sulfur amino acid catabolic process (GO:0000098)5.02240538
24negative regulation of fibrinolysis (GO:0051918)4.86789782
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.84299442
26mitotic chromosome condensation (GO:0007076)4.81052473
27lysine catabolic process (GO:0006554)4.75178653
28lysine metabolic process (GO:0006553)4.75178653
29high-density lipoprotein particle remodeling (GO:0034375)4.72898220
30bile acid metabolic process (GO:0008206)4.71996898
31regulation of protein activation cascade (GO:2000257)4.70210433
32complement activation, alternative pathway (GO:0006957)4.68913212
33regulation of fibrinolysis (GO:0051917)4.68328694
34peptidyl-glutamic acid carboxylation (GO:0017187)4.68119469
35protein carboxylation (GO:0018214)4.68119469
36nitrogen cycle metabolic process (GO:0071941)4.67299430
37serine family amino acid catabolic process (GO:0009071)4.66547901
38aromatic amino acid family metabolic process (GO:0009072)4.60888452
39tyrosine metabolic process (GO:0006570)4.49907394
40cellular glucuronidation (GO:0052695)4.46686600
41bile acid and bile salt transport (GO:0015721)4.42177229
42acylglycerol homeostasis (GO:0055090)4.40164405
43triglyceride homeostasis (GO:0070328)4.40164405
44regulation of complement activation (GO:0030449)4.38778225
45regulation of triglyceride catabolic process (GO:0010896)4.38271160
46drug transmembrane transport (GO:0006855)4.29286746
47alpha-amino acid catabolic process (GO:1901606)4.28572712
48indolalkylamine metabolic process (GO:0006586)4.23104304
49reverse cholesterol transport (GO:0043691)4.21594614
50amino-acid betaine metabolic process (GO:0006577)4.21559312
51cellular biogenic amine catabolic process (GO:0042402)4.13378291
52amine catabolic process (GO:0009310)4.13378291
53glutamate metabolic process (GO:0006536)4.07849218
54negative regulation of cholesterol transport (GO:0032375)4.07386702
55negative regulation of sterol transport (GO:0032372)4.07386702
56serine family amino acid metabolic process (GO:0009069)4.07348729
57plasma lipoprotein particle remodeling (GO:0034369)4.05996755
58protein-lipid complex remodeling (GO:0034368)4.05996755
59macromolecular complex remodeling (GO:0034367)4.05996755
60glucuronate metabolic process (GO:0019585)4.05759995
61uronic acid metabolic process (GO:0006063)4.05759995
62coenzyme catabolic process (GO:0009109)4.03563349
63drug catabolic process (GO:0042737)4.02790222
64plasma lipoprotein particle clearance (GO:0034381)3.99808534
65benzene-containing compound metabolic process (GO:0042537)3.99079416
66phospholipid efflux (GO:0033700)3.98211794
67imidazole-containing compound metabolic process (GO:0052803)3.97359188
68cellular amino acid catabolic process (GO:0009063)3.94879907
69dicarboxylic acid biosynthetic process (GO:0043650)3.91264073
70cellular modified amino acid catabolic process (GO:0042219)3.88642597
71serine family amino acid biosynthetic process (GO:0009070)3.86891776
72urate metabolic process (GO:0046415)3.86500977
73regulation of cholesterol esterification (GO:0010872)3.85369287
74response to nitrosative stress (GO:0051409)3.85201359
75cholesterol efflux (GO:0033344)3.84764302
76cellular ketone body metabolic process (GO:0046950)3.84470809
77glycine metabolic process (GO:0006544)3.84063034
78regulation of bile acid biosynthetic process (GO:0070857)3.80957224
79ethanol oxidation (GO:0006069)3.79117663
80positive regulation of triglyceride lipase activity (GO:0061365)3.78339729
81positive regulation of lipoprotein lipase activity (GO:0051006)3.78339729
82very-low-density lipoprotein particle assembly (GO:0034379)3.75195477
83ribosome assembly (GO:0042255)3.74252931
84plasma lipoprotein particle assembly (GO:0034377)3.70715342
85DNA unwinding involved in DNA replication (GO:0006268)3.66809392
86cholesterol homeostasis (GO:0042632)3.62896741
87positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.62291104
88positive regulation of mitotic sister chromatid separation (GO:1901970)3.62291104
89positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.62291104
90sterol homeostasis (GO:0055092)3.61043143
91short-chain fatty acid metabolic process (GO:0046459)3.60405402
92phospholipid homeostasis (GO:0055091)3.59357884
93fibrinolysis (GO:0042730)3.59169541
94intestinal cholesterol absorption (GO:0030299)3.58659608
95regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.57432368
96regulation of cholesterol homeostasis (GO:2000188)3.56816182
97exogenous drug catabolic process (GO:0042738)3.51859086
98mitotic metaphase plate congression (GO:0007080)3.51227921
99protein localization to chromosome, centromeric region (GO:0071459)3.50161166
100aldehyde catabolic process (GO:0046185)3.49619957
101NAD biosynthetic process (GO:0009435)3.48677516
102nicotinamide nucleotide biosynthetic process (GO:0019359)3.47733213
103pyridine nucleotide biosynthetic process (GO:0019363)3.47733213
104acetyl-CoA metabolic process (GO:0006084)3.46904809
105drug transport (GO:0015893)3.45327360
106carboxylic acid catabolic process (GO:0046395)3.45083224
107organic acid catabolic process (GO:0016054)3.45083224
108cofactor catabolic process (GO:0051187)3.43972601
109positive regulation of lipid catabolic process (GO:0050996)3.42573680
110lipoprotein metabolic process (GO:0042157)3.42323873
111blood coagulation, intrinsic pathway (GO:0007597)3.40631623
112protein-lipid complex assembly (GO:0065005)3.37134818
113aspartate family amino acid catabolic process (GO:0009068)3.35892609
114mitotic nuclear envelope disassembly (GO:0007077)3.35800922
115nuclear envelope disassembly (GO:0051081)3.34928341
116membrane disassembly (GO:0030397)3.34928341
117regulation of RNA export from nucleus (GO:0046831)3.33426715
118dosage compensation (GO:0007549)3.23033474
119DNA duplex unwinding (GO:0032508)3.12708489
120positive regulation of chromosome segregation (GO:0051984)3.10290701
121sister chromatid segregation (GO:0000819)3.09745393
122establishment of chromosome localization (GO:0051303)3.05317992
123positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.02499494
124metaphase plate congression (GO:0051310)3.01568729
125DNA geometric change (GO:0032392)3.01049225
126COPII vesicle coating (GO:0048208)3.01039405
127cellular protein complex localization (GO:0034629)2.98968133
128regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.98723124
129ER overload response (GO:0006983)2.96083594
130cellular response to ethanol (GO:0071361)2.95861634
131iron ion import (GO:0097286)2.90647548
132monoubiquitinated protein deubiquitination (GO:0035520)2.89740253
133cytoplasmic mRNA processing body assembly (GO:0033962)2.88806177
134mitotic sister chromatid segregation (GO:0000070)2.85858825
135folic acid-containing compound biosynthetic process (GO:0009396)2.85081571
136regulation of nucleobase-containing compound transport (GO:0032239)2.79429578
137regulation of translational fidelity (GO:0006450)2.77916534
138regulation of sister chromatid cohesion (GO:0007063)2.77218853
139hepatocyte apoptotic process (GO:0097284)2.75978188
140embryonic process involved in female pregnancy (GO:0060136)2.73840181
141protein export from nucleus (GO:0006611)2.72879276
142negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.72572182
143nuclear envelope organization (GO:0006998)2.71868136
144hypotonic response (GO:0006971)2.71783282
145response to peptidoglycan (GO:0032494)2.66086653
146chromosome condensation (GO:0030261)2.65255639
147histone phosphorylation (GO:0016572)2.64213306
148negative regulation of DNA repair (GO:0045738)2.63329962
149necroptotic process (GO:0070266)2.62495768
150regulation of DNA endoreduplication (GO:0032875)2.61732298
151non-recombinational repair (GO:0000726)2.59866398
152double-strand break repair via nonhomologous end joining (GO:0006303)2.59866398
153regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.59168232
154regulation of mitotic metaphase/anaphase transition (GO:0030071)2.59168232
155negative regulation of interleukin-12 production (GO:0032695)2.58628829
156RNA stabilization (GO:0043489)2.57569749
157mRNA stabilization (GO:0048255)2.57569749
158DNA conformation change (GO:0071103)2.57429828
159mRNA modification (GO:0016556)2.56699969
160regulation of centriole replication (GO:0046599)2.55123890
161protein localization to kinetochore (GO:0034501)2.54991356
162nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.54117676
163regulation of chromosome segregation (GO:0051983)2.53662610
164sister chromatid cohesion (GO:0007062)2.52139149
165oligosaccharide catabolic process (GO:0009313)2.51511474
166regulation of translational termination (GO:0006449)2.49440247
167cytoskeleton-dependent cytokinesis (GO:0061640)2.49198165
168protein localization to endosome (GO:0036010)2.48894123
169detection of molecule of bacterial origin (GO:0032490)2.46931224
170pre-miRNA processing (GO:0031054)2.45460120
171Golgi transport vesicle coating (GO:0048200)2.42276445
172COPI coating of Golgi vesicle (GO:0048205)2.42276445
173neutrophil activation involved in immune response (GO:0002283)2.42030372
174regulation of sister chromatid segregation (GO:0033045)2.41634792
175regulation of mitotic sister chromatid separation (GO:0010965)2.41634792
176regulation of mitotic sister chromatid segregation (GO:0033047)2.41634792
177protein complex localization (GO:0031503)2.38074116
178regulation of histone H3-K27 methylation (GO:0061085)2.35723666
179DNA packaging (GO:0006323)2.35586489
180histone mRNA catabolic process (GO:0071044)2.35307347
181negative regulation of protein localization to plasma membrane (GO:1903077)2.34081786
182protein localization to chromosome (GO:0034502)2.33864470
183DNA synthesis involved in DNA repair (GO:0000731)2.33257601
184mitotic cytokinesis (GO:0000281)2.30612438
185peptidyl-threonine dephosphorylation (GO:0035970)2.30138344
186negative regulation of chromosome segregation (GO:0051985)2.29820830
187spliceosomal tri-snRNP complex assembly (GO:0000244)2.29513481
188pteridine-containing compound biosynthetic process (GO:0042559)2.28990677
189meiotic chromosome segregation (GO:0045132)2.28699109
190regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.28586899
191cellular response to arsenic-containing substance (GO:0071243)2.27040608
192spindle checkpoint (GO:0031577)2.23526828
193negative regulation of mitotic sister chromatid separation (GO:2000816)2.23119614
194negative regulation of sister chromatid segregation (GO:0033046)2.23119614
195negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.23119614
196negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.23119614
197negative regulation of mitotic sister chromatid segregation (GO:0033048)2.23119614
198histone-serine phosphorylation (GO:0035404)2.22543666
199negative regulation of fibroblast apoptotic process (GO:2000270)2.22403457
200mitotic spindle checkpoint (GO:0071174)2.22099418

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.93247612
2* RXR_22158963_ChIP-Seq_LIVER_Mouse7.23484397
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.44605377
4PPARA_22158963_ChIP-Seq_LIVER_Mouse6.16186284
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.91465516
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.33571584
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.25533997
8EGR1_19374776_ChIP-ChIP_THP-1_Human4.20023332
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.94762916
10* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.66408588
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.45082173
12* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.24384151
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.03941323
14KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.74891889
15GATA1_22025678_ChIP-Seq_K562_Human2.65614579
16AR_21909140_ChIP-Seq_LNCAP_Human2.53948599
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.46971843
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.41936894
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.25991663
20TFEB_21752829_ChIP-Seq_HELA_Human2.11165478
21PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.10312088
22SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.06464206
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.01363359
24* ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.0637523
25* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.93493655
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.93183059
27TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.92316207
28CLOCK_20551151_ChIP-Seq_293T_Human1.86573191
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.84836233
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84165775
31* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.83326316
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.81283432
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.80369321
34FOXA2_19822575_ChIP-Seq_HepG2_Human1.72845912
35* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70979849
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.69786449
37* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60748840
38Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.59829127
39* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59026668
40* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.58796131
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.55010113
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53875264
43* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.50847481
44SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.49881786
45SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.49881786
46ELK1_19687146_ChIP-ChIP_HELA_Human1.48216792
47DCP1A_22483619_ChIP-Seq_HELA_Human1.47619252
48EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46899420
49ERG_20887958_ChIP-Seq_HPC-7_Mouse1.43287380
50MYC_22102868_ChIP-Seq_BL_Human1.42246153
51* HNF4A_19822575_ChIP-Seq_HepG2_Human1.41433266
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.41155094
53TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.40628384
54SOX2_27498859_Chip-Seq_STOMACH_Mouse1.40595200
55MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.40488937
56* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.40096979
57* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.38918997
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36575049
59PU_27001747_Chip-Seq_BMDM_Mouse1.35364516
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34693482
61SPI1_23547873_ChIP-Seq_NB4_Human1.33909595
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33586230
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.29595729
64KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.29060536
65* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25804854
66* HTT_18923047_ChIP-ChIP_STHdh_Human1.24673711
67NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24637363
68NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24637363
69GATA4_25053715_ChIP-Seq_YYC3_Human1.23999433
70CREB1_15753290_ChIP-ChIP_HEK293T_Human1.23642573
71MYC_19030024_ChIP-ChIP_MESCs_Mouse1.22909156
72KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21836110
73RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20742362
74MYB_26560356_Chip-Seq_TH1_Human1.19507889
75CHD1_26751641_Chip-Seq_LNCaP_Human1.19312429
76YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17507823
77SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16828345
78WT1_19549856_ChIP-ChIP_CCG9911_Human1.15647030
79TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.11922578
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11547007
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11105619
82MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.11098306
83HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.10533267
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10440398
85BRD4_25478319_ChIP-Seq_HGPS_Human1.09523678
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09323727
87SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.09224193
88* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.07391604
89* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06319830
90ELF1_17652178_ChIP-ChIP_JURKAT_Human1.06140578
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05927016
92SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05821194
93KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05612569
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05155662
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04037332
96FOXO3_23340844_ChIP-Seq_DLD1_Human1.02355467
97AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01566853
98* IRF8_27001747_Chip-Seq_BMDM_Mouse1.01193089
99SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00779443
100FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00265805
101* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98959159
102MYB_26560356_Chip-Seq_TH2_Human0.98496556
103STAT4_19710469_ChIP-ChIP_TH1__Mouse0.96074937
104FOXA1_25552417_ChIP-Seq_VCAP_Human0.94478784
105FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.93960807
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92034370
107CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91877193
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91659740
109NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.91642653
110FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.91270198
111VDR_23849224_ChIP-Seq_CD4+_Human0.91161585
112* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.90832656
113GATA4_21415370_ChIP-Seq_HL-1_Mouse0.88279089
114GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87836020
115KDM5A_27292631_Chip-Seq_BREAST_Human0.87101853
116PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86298707
117* RUNX1_22412390_ChIP-Seq_EML_Mouse0.86237571
118BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.85925438
119CDX2_20551321_ChIP-Seq_CACO-2_Human0.85615457
120AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84961013
121FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.83143590
122MYC_19079543_ChIP-ChIP_MESCs_Mouse0.83035537
123CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.82478970
124ESR1_21235772_ChIP-Seq_MCF-7_Human0.81818855
125TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.81519471
126MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.81043665
127CDX2_22108803_ChIP-Seq_LS180_Human0.80301721
128ATF3_27146783_Chip-Seq_COLON_Human0.79985261
129CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.79443757
130FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.79338895
131SOX2_20726797_ChIP-Seq_SW620_Human0.78313077
132PIAS1_25552417_ChIP-Seq_VCAP_Human0.76865552
133ESR2_21235772_ChIP-Seq_MCF-7_Human0.76613491
134ZNF217_24962896_ChIP-Seq_MCF-7_Human0.74306445
135RXRA_24833708_ChIP-Seq_LIVER_Mouse0.72861477
136TAF15_26573619_Chip-Seq_HEK293_Human0.72729731
137ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.72656513
138ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.72515690
139RUNX_20019798_ChIP-Seq_JUKART_Human0.71748256
140GATA2_21666600_ChIP-Seq_HMVEC_Human0.70170202
141IRF1_19129219_ChIP-ChIP_H3396_Human0.69720365
142EZH2_27294783_Chip-Seq_NPCs_Mouse0.69585683
143GATA6_25053715_ChIP-Seq_YYC3_Human0.67568115
144ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.67514082
145EGR1_19032775_ChIP-ChIP_M12_Human0.67139609
146IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.66241646
147PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.65658302
148THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.64348382
149AUTS2_25519132_ChIP-Seq_293T-REX_Human0.64217884
150GATA2_19941826_ChIP-Seq_K562_Human0.63837490
151FOXM1_26456572_ChIP-Seq_MCF-7_Human0.63538891
152CDX2_19796622_ChIP-Seq_MESCs_Mouse0.62154422
153SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.61808902
154TP63_23658742_ChIP-Seq_EP156T_Human0.61454119
155ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.61302875
156BCAT_22108803_ChIP-Seq_LS180_Human0.60844098
157ESR1_20079471_ChIP-ChIP_T-47D_Human0.60842454
158* CBP_21632823_ChIP-Seq_H3396_Human0.60154205
159CEBPB_22108803_ChIP-Seq_LS180_Human0.60123023
160OCT4_21477851_ChIP-Seq_ESCs_Mouse0.59948404
161BRD4_27068464_Chip-Seq_AML-cells_Mouse0.59943894
162PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.58972290
163TRIM28_21343339_ChIP-Seq_HEK293_Human0.58563346
164GATA1_19941826_ChIP-Seq_K562_Human0.57926134
165IRF8_21731497_ChIP-ChIP_J774_Mouse0.57124011
166ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.57039460
167SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.56659356
168RARG_19884340_ChIP-ChIP_MEFs_Mouse0.56297277
169* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.55815608
170KAP1_22055183_ChIP-Seq_ESCs_Mouse0.55635898
171NFE2_27457419_Chip-Seq_LIVER_Mouse0.55503416
172STAT1_17558387_ChIP-Seq_HELA_Human0.55357747
173CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.54754909
174STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.54665784
175POU3F2_20337985_ChIP-ChIP_501MEL_Human0.54649167
176EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.54250946

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.74200356
2MP0005360_urolithiasis7.41305285
3MP0005085_abnormal_gallbladder_physiolo5.93466025
4MP0005365_abnormal_bile_salt5.60787011
5MP0008875_abnormal_xenobiotic_pharmacok4.77821702
6MP0008057_abnormal_DNA_replication4.43603084
7* MP0003252_abnormal_bile_duct4.24017145
8MP0010352_gastrointestinal_tract_polyps4.05227849
9MP0003806_abnormal_nucleotide_metabolis3.88218132
10MP0010329_abnormal_lipoprotein_level3.21518527
11MP0003195_calcinosis3.20292281
12MP0002138_abnormal_hepatobiliary_system2.87551155
13MP0001666_abnormal_nutrient_absorption2.84950418
14MP0005332_abnormal_amino_acid2.74459142
15MP0003111_abnormal_nucleus_morphology2.61623119
16MP0010094_abnormal_chromosome_stability2.58980245
17MP0005083_abnormal_biliary_tract2.53442599
18MP0002009_preneoplasia2.40246497
19MP0004019_abnormal_vitamin_homeostasis2.39349701
20* MP0010234_abnormal_vibrissa_follicle2.32216742
21MP0009840_abnormal_foam_cell2.26392424
22MP0004957_abnormal_blastocyst_morpholog2.25299944
23MP0000569_abnormal_digit_pigmentation2.16208055
24MP0003868_abnormal_feces_composition2.11086014
25MP0005076_abnormal_cell_differentiation2.07081172
26* MP0000609_abnormal_liver_physiology2.05890126
27MP0003077_abnormal_cell_cycle2.01774801
28MP0003191_abnormal_cellular_cholesterol2.01027580
29* MP0002118_abnormal_lipid_homeostasis1.96481052
30MP0003693_abnormal_embryo_hatching1.93739685
31MP0010307_abnormal_tumor_latency1.93307605
32MP0003303_peritoneal_inflammation1.87081340
33MP0002396_abnormal_hematopoietic_system1.83844848
34MP0008007_abnormal_cellular_replicative1.80977620
35MP0003221_abnormal_cardiomyocyte_apopto1.75495876
36* MP0005319_abnormal_enzyme/_coenzyme1.64906081
37MP0004808_abnormal_hematopoietic_stem1.60360318
38MP0004233_abnormal_muscle_weight1.55995959
39* MP0009643_abnormal_urine_homeostasis1.54266520
40MP0001730_embryonic_growth_arrest1.52811293
41MP0005451_abnormal_body_composition1.51725639
42MP0001764_abnormal_homeostasis1.51431925
43MP0003950_abnormal_plasma_membrane1.48327925
44MP0008058_abnormal_DNA_repair1.45430810
45MP0003828_pulmonary_edema1.44290736
46MP0005584_abnormal_enzyme/coenzyme_acti1.43772945
47MP0009697_abnormal_copulation1.39695436
48MP0008260_abnormal_autophagy1.39077470
49MP0000350_abnormal_cell_proliferation1.32087176
50MP0002006_tumorigenesis1.30175365
51MP0003186_abnormal_redox_activity1.24678479
52MP0009764_decreased_sensitivity_to1.24171859
53MP0003763_abnormal_thymus_physiology1.21762085
54MP0003448_altered_tumor_morphology1.21343238
55MP0001915_intracranial_hemorrhage1.20923237
56* MP0000598_abnormal_liver_morphology1.19595774
57MP0005408_hypopigmentation1.18426549
58MP0003566_abnormal_cell_adhesion1.17547802
59* MP0002086_abnormal_extraembryonic_tissu1.14828238
60MP0000490_abnormal_crypts_of1.11652643
61MP0009763_increased_sensitivity_to1.10710890
62MP0005647_abnormal_sex_gland1.10619704
63MP0003656_abnormal_erythrocyte_physiolo1.08815881
64MP0005636_abnormal_mineral_homeostasis1.07692894
65MP0000858_altered_metastatic_potential1.07114042
66* MP0003091_abnormal_cell_migration1.06950810
67MP0001697_abnormal_embryo_size1.05378671
68* MP0008469_abnormal_protein_level1.04434310
69MP0005380_embryogenesis_phenotype1.04377862
70MP0001672_abnormal_embryogenesis/_devel1.04377862
71* MP0003453_abnormal_keratinocyte_physiol1.04211726
72* MP0001216_abnormal_epidermal_layer1.03219734
73MP0005310_abnormal_salivary_gland1.02838465
74* MP0005621_abnormal_cell_physiology1.02374008
75MP0003984_embryonic_growth_retardation1.01840358
76MP0002876_abnormal_thyroid_physiology1.00707393
77* MP0010678_abnormal_skin_adnexa1.00217813
78MP0000015_abnormal_ear_pigmentation1.00203436
79MP0003300_gastrointestinal_ulcer1.00143075
80MP0003690_abnormal_glial_cell0.99907148
81MP0005409_darkened_coat_color0.99343684
82MP0000371_diluted_coat_color0.99161399
83MP0002088_abnormal_embryonic_growth/wei0.98821001
84* MP0002080_prenatal_lethality0.96998209
85MP0005220_abnormal_exocrine_pancreas0.94057472
86MP0009765_abnormal_xenobiotic_induced0.92960106
87MP0000313_abnormal_cell_death0.92410798
88MP0002405_respiratory_system_inflammati0.92151730
89MP0000604_amyloidosis0.90974324
90MP0000685_abnormal_immune_system0.90919299
91* MP0002398_abnormal_bone_marrow0.90355700
92MP0003705_abnormal_hypodermis_morpholog0.90110828
93MP0006054_spinal_hemorrhage0.88997265
94MP0003172_abnormal_lysosome_physiology0.88748748
95* MP0009642_abnormal_blood_homeostasis0.87440359
96MP0001727_abnormal_embryo_implantation0.85726001
97* MP0002019_abnormal_tumor_incidence0.85269821
98MP0005174_abnormal_tail_pigmentation0.84225192
99MP0002254_reproductive_system_inflammat0.83125544
100MP0005375_adipose_tissue_phenotype0.83096830
101MP0003786_premature_aging0.82726819
102MP0000703_abnormal_thymus_morphology0.82431824
103* MP0002136_abnormal_kidney_physiology0.81966802
104* MP0005384_cellular_phenotype0.81593273
105* MP0002928_abnormal_bile_duct0.81433545
106MP0004043_abnormal_pH_regulation0.81429109
107MP0006082_CNS_inflammation0.80802152
108MP0008932_abnormal_embryonic_tissue0.80640545
109* MP0005000_abnormal_immune_tolerance0.80241852
110* MP0002060_abnormal_skin_morphology0.79177208
111MP0000465_gastrointestinal_hemorrhage0.76630017
112MP0003724_increased_susceptibility_to0.76035101
113* MP0002452_abnormal_antigen_presenting0.75696013
114MP0002078_abnormal_glucose_homeostasis0.75496244
115MP0002722_abnormal_immune_system0.75252391
116* MP0001191_abnormal_skin_condition0.74186272
117MP0005670_abnormal_white_adipose0.73519020
118MP0001756_abnormal_urination0.73089705
119MP0003011_delayed_dark_adaptation0.72504224
120MP0005464_abnormal_platelet_physiology0.72399046
121MP0001186_pigmentation_phenotype0.72279370
122* MP0000627_abnormal_mammary_gland0.72140866
123MP0004197_abnormal_fetal_growth/weight/0.72106933
124MP0002971_abnormal_brown_adipose0.71954192
125MP0002970_abnormal_white_adipose0.70854354
126MP0005334_abnormal_fat_pad0.70368784
127MP0001800_abnormal_humoral_immune0.70031451
128* MP0002796_impaired_skin_barrier0.69700526
129MP0005058_abnormal_lysosome_morphology0.69289482
130MP0003436_decreased_susceptibility_to0.67788163
131MP0004264_abnormal_extraembryonic_tissu0.66531504
132MP0001661_extended_life_span0.62740307
133MP0005376_homeostasis/metabolism_phenot0.62486058
134MP0005167_abnormal_blood-brain_barrier0.62225663
135MP0005666_abnormal_adipose_tissue0.60492594
136MP0005535_abnormal_body_temperature0.59859531
137MP0009384_cardiac_valve_regurgitation0.58044467
138MP0009053_abnormal_anal_canal0.57732941
139* MP0005084_abnormal_gallbladder_morpholo0.57386576
140MP0001835_abnormal_antigen_presentation0.57217445
141MP0001765_abnormal_ion_homeostasis0.56913974
142* MP0001845_abnormal_inflammatory_respons0.55319824
143MP0004381_abnormal_hair_follicle0.54563384
144MP0004782_abnormal_surfactant_physiolog0.53751043
145MP0002132_abnormal_respiratory_system0.52328570
146MP0005387_immune_system_phenotype0.51922102
147MP0001790_abnormal_immune_system0.51922102
148MP0005166_decreased_susceptibility_to0.50687476
149MP0005395_other_phenotype0.48053657
150MP0002168_other_aberrant_phenotype0.46327617
151* MP0002419_abnormal_innate_immunity0.45841027
152MP0010368_abnormal_lymphatic_system0.45670625
153MP0004947_skin_inflammation0.45395359
154MP0005448_abnormal_energy_balance0.44099489
155MP0009785_altered_susceptibility_to0.44004668
156MP0008873_increased_physiological_sensi0.42989770
157MP0010155_abnormal_intestine_physiology0.42532043
158MP0004130_abnormal_muscle_cell0.41774255
159MP0001853_heart_inflammation0.40951383
160MP0004147_increased_porphyrin_level0.40668086
161MP0003075_altered_response_to0.39474899
162MP0006036_abnormal_mitochondrial_physio0.37953645
163MP0004185_abnormal_adipocyte_glucose0.37351490
164MP0005266_abnormal_metabolism0.36883440
165MP0005025_abnormal_response_to0.36802016
166* MP0001881_abnormal_mammary_gland0.36727268
167MP0003953_abnormal_hormone_level0.36479871
168MP0009672_abnormal_birth_weight0.35394920
169MP0002166_altered_tumor_susceptibility0.34391041
170MP0002877_abnormal_melanocyte_morpholog0.34028960
171MP0003638_abnormal_response/metabolism_0.33777978
172MP0000249_abnormal_blood_vessel0.33616523
173MP0005248_abnormal_Harderian_gland0.33538536

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.20741188
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.59425596
3Deep venous thrombosis (HP:0002625)6.47826498
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.27606328
5Prolonged partial thromboplastin time (HP:0003645)5.79220511
6Xanthomatosis (HP:0000991)5.71656261
7Hypobetalipoproteinemia (HP:0003563)5.42937598
8Hyperlipoproteinemia (HP:0010980)4.99054256
9Joint hemorrhage (HP:0005261)4.58310304
10Complement deficiency (HP:0004431)4.56381099
11Abnormality of glutamine family amino acid metabolism (HP:0010902)4.43505026
12Epidermoid cyst (HP:0200040)4.36320058
13Fat malabsorption (HP:0002630)4.32350003
14Abnormality of sulfur amino acid metabolism (HP:0004339)4.31106563
15Abnormality of aspartate family amino acid metabolism (HP:0010899)4.25089142
16Abnormality of the common coagulation pathway (HP:0010990)4.11748072
17Abnormality of methionine metabolism (HP:0010901)4.06685869
18Hypolipoproteinemia (HP:0010981)4.04106067
19Hyperglycinemia (HP:0002154)3.96513270
20Conjugated hyperbilirubinemia (HP:0002908)3.93452836
21Hyperammonemia (HP:0001987)3.91139456
22Hyperglycinuria (HP:0003108)3.90937929
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.89941689
24Ketosis (HP:0001946)3.86749010
25Abnormality of glycine metabolism (HP:0010895)3.83161156
26Abnormality of serine family amino acid metabolism (HP:0010894)3.83161156
27Papillary thyroid carcinoma (HP:0002895)3.72174032
28Abnormality of the intrinsic pathway (HP:0010989)3.62150532
29Hypoglycemic coma (HP:0001325)3.60084405
30Hypoalphalipoproteinemia (HP:0003233)3.52290887
31Abnormality of pyrimidine metabolism (HP:0004353)3.50468782
32Subacute progressive viral hepatitis (HP:0006572)3.48658198
33Hypercholesterolemia (HP:0003124)3.39475205
34Myocardial infarction (HP:0001658)3.39363399
35Steatorrhea (HP:0002570)3.35050299
36Abnormality of complement system (HP:0005339)3.32764827
37Chromosomal breakage induced by crosslinking agents (HP:0003221)3.19234497
38Progressive external ophthalmoplegia (HP:0000590)3.13392491
39Hyperbilirubinemia (HP:0002904)3.12530375
40Chromsome breakage (HP:0040012)3.11911553
41Abnormality of nucleobase metabolism (HP:0010932)3.08934771
42Progressive muscle weakness (HP:0003323)3.04653746
43Fatigue (HP:0012378)3.02817498
44Vascular calcification (HP:0004934)2.99878987
45Hypoglycemic seizures (HP:0002173)2.98076570
46Hepatocellular carcinoma (HP:0001402)2.96336182
47Abnormality of fatty-acid metabolism (HP:0004359)2.93428529
48Deep philtrum (HP:0002002)2.90387948
49Abnormality of purine metabolism (HP:0004352)2.88167765
50Ketoacidosis (HP:0001993)2.86619999
51Hypochromic microcytic anemia (HP:0004840)2.82818377
52Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.77443883
53Acanthocytosis (HP:0001927)2.76640264
54Abnormality of serum amino acid levels (HP:0003112)2.71758584
55Termporal pattern (HP:0011008)2.67882765
56Insidious onset (HP:0003587)2.67882765
57Delayed CNS myelination (HP:0002188)2.67224559
58Cardiovascular calcification (HP:0011915)2.66223668
59Skin nodule (HP:0200036)2.64407358
60Metabolic acidosis (HP:0001942)2.59156318
61Spontaneous abortion (HP:0005268)2.59009348
62Gingival bleeding (HP:0000225)2.57672757
63Recurrent gram-negative bacterial infections (HP:0005420)2.56977634
64Spinal cord lesions (HP:0100561)2.55495791
65Syringomyelia (HP:0003396)2.55495791
66Mitral stenosis (HP:0001718)2.53842079
67Volvulus (HP:0002580)2.53762287
68Gout (HP:0001997)2.53469638
69Rickets (HP:0002748)2.51287078
70Disinhibition (HP:0000734)2.50918715
71Acute myeloid leukemia (HP:0004808)2.48754540
72Micronodular cirrhosis (HP:0001413)2.48490793
73Scanning speech (HP:0002168)2.48238011
74Orthostatic hypotension (HP:0001278)2.47313995
75Systemic lupus erythematosus (HP:0002725)2.45984685
76Transitional cell carcinoma of the bladder (HP:0006740)2.45591278
77Spastic diplegia (HP:0001264)2.44164468
78Thyroid carcinoma (HP:0002890)2.43939073
79Recurrent bacterial skin infections (HP:0005406)2.42844467
80Lower limb hyperreflexia (HP:0002395)2.40806184
81Esophageal varix (HP:0002040)2.39985945
82Curly hair (HP:0002212)2.35359973
83Bladder carcinoma (HP:0002862)2.33970284
84Bladder neoplasm (HP:0009725)2.33970284
85Hydroxyprolinuria (HP:0003080)2.32457174
86Abnormality of proline metabolism (HP:0010907)2.32457174
87Hypophosphatemic rickets (HP:0004912)2.31629810
88Recurrent abscess formation (HP:0002722)2.31482836
89Septate vagina (HP:0001153)2.31000003
90Menorrhagia (HP:0000132)2.30624198
91Tetraparesis (HP:0002273)2.28619164
92Dicarboxylic aciduria (HP:0003215)2.27153986
93Abnormality of dicarboxylic acid metabolism (HP:0010995)2.27153986
94Pancreatitis (HP:0001733)2.27000819
95Abnormal enzyme/coenzyme activity (HP:0012379)2.26673156
96Ankyloglossia (HP:0010296)2.26246130
97Abnormal foot bone ossification (HP:0010675)2.24228364
98Eczematoid dermatitis (HP:0000976)2.23170908
99Asymmetry of the thorax (HP:0001555)2.20872339
100Glomerulonephritis (HP:0000099)2.19356901
101Irritability (HP:0000737)2.18387512
102Abnormality of chromosome stability (HP:0003220)2.17602673
103Abnormality of liposaccharide metabolism (HP:0010968)2.17592513
104Abnormality of glycosphingolipid metabolism (HP:0004343)2.17592513
105Abnormality of glycolipid metabolism (HP:0010969)2.17592513
106Enlarged kidneys (HP:0000105)2.17005338
107Generalized aminoaciduria (HP:0002909)2.15825123
108Proximal tubulopathy (HP:0000114)2.14962792
109Elevated alkaline phosphatase (HP:0003155)2.14420488
110Sensorimotor neuropathy (HP:0007141)2.13765452
111Medulloblastoma (HP:0002885)2.13750169
112Leiomyosarcoma (HP:0100243)2.13010435
113Uterine leiomyosarcoma (HP:0002891)2.13010435
114Lethargy (HP:0001254)2.12960179
115Multiple enchondromatosis (HP:0005701)2.12603154
116Malnutrition (HP:0004395)2.11369165
117Alkalosis (HP:0001948)2.10656950
118Renal cortical cysts (HP:0000803)2.10050894
119Abnormal gallbladder morphology (HP:0012437)2.09746686
120Symptomatic seizures (HP:0011145)2.08823449
121Abnormal umbilical cord blood vessels (HP:0011403)2.08005215
122Single umbilical artery (HP:0001195)2.08005215
123Abnormality of the fetal cardiovascular system (HP:0010948)2.08005215
124Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.06533098
125Abnormality of alkaline phosphatase activity (HP:0004379)2.05152757
126Thrombophlebitis (HP:0004418)2.03097008
127Osteolytic defects of the hand bones (HP:0009699)2.02660179
128Osteolytic defects of the phalanges of the hand (HP:0009771)2.02660179
129Increased mean platelet volume (HP:0011877)2.01616604
130Gastrointestinal carcinoma (HP:0002672)1.98993116
131Malignant gastrointestinal tract tumors (HP:0006749)1.98993116
132Amyloidosis (HP:0011034)1.97497777
133Hemorrhage of the eye (HP:0011885)1.96673325
134Periodontitis (HP:0000704)1.96025745
135Acute hepatic failure (HP:0006554)1.95951153
136Abnormality of transition element cation homeostasis (HP:0011030)1.95813570
137Poikilocytosis (HP:0004447)1.94474684
138Abnormality of oral frenula (HP:0000190)1.92725303
139Hyperinsulinemic hypoglycemia (HP:0000825)1.90977975
140Abnormality of iron homeostasis (HP:0011031)1.90853672
141Viral hepatitis (HP:0006562)1.90634713
142Abnormal platelet volume (HP:0011876)1.90532041
143Resting tremor (HP:0002322)1.90093750
144Prominent nose (HP:0000448)1.90034419
145Abnormality of the vasculature of the conjunctiva (HP:0008054)1.90030669
146Fair hair (HP:0002286)1.89392593
147Opisthotonus (HP:0002179)1.89365532
148Cholelithiasis (HP:0001081)1.89277036
149Pelvic girdle muscle weakness (HP:0003749)1.88661582
150Abnormality of vitamin metabolism (HP:0100508)1.88126453
151Confusion (HP:0001289)1.88037247
152T lymphocytopenia (HP:0005403)1.87561753
153Renal cell carcinoma (HP:0005584)1.87095175
154Bilateral sensorineural hearing impairment (HP:0008619)1.85897559
155Abnormality of urine glucose concentration (HP:0011016)1.85156385
156Glycosuria (HP:0003076)1.85156385
157Short chin (HP:0000331)1.84954983
158Abnormal cartilage morphology (HP:0002763)1.84723046
159Autoimmune hemolytic anemia (HP:0001890)1.84641929
160Autoamputation (HP:0001218)1.84565929
161Increased purine levels (HP:0004368)1.84516826
162Coarse hair (HP:0002208)1.84316568
163Selective tooth agenesis (HP:0001592)1.82400162
164Rhabdomyosarcoma (HP:0002859)1.82231030
165Cafe-au-lait spot (HP:0000957)1.82112870
166Low anterior hairline (HP:0000294)1.80969599
167Upper motor neuron abnormality (HP:0002127)1.78966633
168Anhidrosis (HP:0000970)1.78120153
169Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.77893998
170Menstrual irregularities (HP:0000858)1.77626689
171Recurrent viral infections (HP:0004429)1.77035844
172Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.75235763
173Aplasia cutis congenita (HP:0001057)1.75168676
174Myelodysplasia (HP:0002863)1.74774133
175Increased nuchal translucency (HP:0010880)1.74700931
176Cubitus valgus (HP:0002967)1.74403967
177Sandal gap (HP:0001852)1.73882136
178Biliary tract neoplasm (HP:0100574)1.73701677
179Inappropriate behavior (HP:0000719)1.73470205
180Neoplasm of the small intestine (HP:0100833)1.72560804
181Abnormality of macrophages (HP:0004311)1.72223944
182Thickened calvaria (HP:0002684)1.69141792
183Conjunctival telangiectasia (HP:0000524)1.68875684
184Abnormality of the pons (HP:0007361)1.68373096
185Abnormality of the gastric mucosa (HP:0004295)1.68060326
186Long clavicles (HP:0000890)1.67739070
187Insomnia (HP:0100785)1.67684364
188Deviation of the thumb (HP:0009603)1.67374833
189Submucous cleft hard palate (HP:0000176)1.66919952
190Abnormality of the preputium (HP:0100587)1.66185042
191Cutaneous melanoma (HP:0012056)1.66163964
192Ragged-red muscle fibers (HP:0003200)1.65391555
193Increased density of long bones (HP:0006392)1.65290699
194Uterine neoplasm (HP:0010784)1.64981215
195Osteomyelitis (HP:0002754)1.64875519
196Abnormality of T cell number (HP:0011839)1.64486043
197Cystic hygroma (HP:0000476)1.63253213

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK35.36951607
2BCKDK3.90864394
3EIF2AK33.33263306
4FGFR43.29773486
5SCYL23.03325090
6MST42.96919381
7SIK12.86567344
8FRK2.73228782
9INSRR2.57718271
10ERBB42.43582020
11ERN12.23188455
12NEK12.09468680
13TTK2.08234048
14PRPF4B2.00282791
15EIF2AK11.99847420
16BUB11.88480897
17TYK21.86512987
18PTK61.73981989
19TNIK1.73689813
20FLT31.67021934
21YES11.66645063
22OXSR11.64294036
23MAP3K31.63365510
24ITK1.63077776
25JAK11.62538657
26MST1R1.62471199
27MAP2K31.61058518
28SRPK11.59358014
29MAP3K21.58549400
30CDC71.50706864
31LATS11.49556251
32TBK11.48518092
33FGFR21.45924226
34* MAP3K141.42975622
35TSSK61.40989870
36BRSK21.36347051
37IRAK31.32045347
38PKN21.31769480
39MAPK151.28909583
40MET1.24243811
41ACVR1B1.24152281
42PBK1.23766255
43ERBB31.23495285
44BMPR21.21041244
45IKBKE1.21031472
46BRD41.20330455
47TAOK11.19305164
48SGK31.18269683
49PRKAA21.17527345
50MAP3K71.17208956
51STK38L1.16258019
52FGFR31.16185992
53JAK21.14240829
54MAPK111.12984682
55CSK1.11512154
56NLK1.10736611
57STK101.10141043
58MAP3K61.09473599
59RIPK11.08076518
60WNK31.07127945
61PIK3CG1.06371654
62KSR11.06214853
63MKNK21.04430006
64SGK21.02439572
65ABL21.00913743
66GRK61.00509248
67TRIB31.00117602
68MAP3K120.99934344
69EPHB10.98715687
70JAK30.98594969
71DYRK1B0.98583882
72STK390.98569812
73SGK2230.96715036
74SGK4940.96715036
75KSR20.96328917
76BMPR1B0.95359266
77STK240.93617260
78CDK60.91964111
79PDGFRA0.91223523
80PLK10.90156924
81BLK0.90026256
82NUAK10.89276059
83TEC0.88736060
84PLK30.88291991
85CHEK20.87471619
86EEF2K0.87178929
87CHEK10.83582635
88RPS6KA40.82955784
89CCNB10.82432769
90ALK0.82292002
91EPHA30.82052255
92RAF10.81864869
93PDK20.81560781
94TTN0.80745138
95CHUK0.79714491
96MAP3K80.79099477
97PTK20.78891607
98IRAK20.78673782
99IRAK10.78128650
100WNK40.78086073
101GSK3A0.77981148
102RPS6KB20.77432760
103NEK90.77202297
104TRPM70.75779929
105DYRK30.74877178
106PDGFRB0.73552542
107PKN10.72937336
108LATS20.72022672
109STK30.71951228
110ICK0.71814567
111MAPK70.71804762
112AKT30.71314918
113* PRKCQ0.70910084
114CSF1R0.70658804
115SMG10.70563696
116FGR0.69112573
117MKNK10.68279907
118IKBKB0.67587789
119MAP3K50.67430530
120ERBB20.66193641
121MAP3K10.66100526
122ABL10.65698848
123NEK60.65600427
124PLK40.65593452
125CAMK1D0.64651449
126IRAK40.64611355
127WEE10.64471670
128IGF1R0.63912339
129PAK40.63808523
130MELK0.62896014
131TIE10.62844539
132MAP2K40.61604309
133MAP4K10.61539815
134NEK20.61156107
135WNK10.60932122
136ATM0.60551091
137CAMK1G0.60526582
138BTK0.58747921
139MAP3K100.58680161
140CSNK1A1L0.58490045
141PASK0.55680554
142CSNK1G10.55290318
143CDK70.54690202
144EPHA20.54495395
145CDK90.54210339
146BRAF0.53993576
147PIM10.52939624
148EGFR0.52031527
149MAPK120.51440509
150TAF10.51281782
151PRKAA10.50580657
152ATR0.49531195
153CLK10.49205092
154CDK120.49188179
155STK160.49101482
156MTOR0.48889169
157MAP3K130.48711911
158STK40.47603822
159TGFBR20.46568777
160MAPK40.44136717
161ZAK0.44124160
162BMX0.43209639
163CDK40.43159000
164TXK0.42500595
165EIF2AK20.41904482
166INSR0.40850566
167PIK3CA0.40237692
168PDPK10.40221547
169FGFR10.39761167
170SGK10.39252954
171EPHB20.37705205

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.29416237
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.46683813
3Nitrogen metabolism_Homo sapiens_hsa009103.25051014
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.80631134
5Arginine biosynthesis_Homo sapiens_hsa002202.74177550
6Tryptophan metabolism_Homo sapiens_hsa003802.71337711
7Complement and coagulation cascades_Homo sapiens_hsa046102.64762147
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.50377014
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.49236730
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.46242125
11Fatty acid degradation_Homo sapiens_hsa000712.40985512
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.38755673
13Non-homologous end-joining_Homo sapiens_hsa034502.32976400
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.31726133
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.29593569
16Cell cycle_Homo sapiens_hsa041102.18882940
17Butanoate metabolism_Homo sapiens_hsa006502.17756538
18Peroxisome_Homo sapiens_hsa041462.15987929
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.14280482
20Histidine metabolism_Homo sapiens_hsa003402.03620264
21Steroid hormone biosynthesis_Homo sapiens_hsa001402.01908071
22Sulfur metabolism_Homo sapiens_hsa009201.91768648
23* Chronic myeloid leukemia_Homo sapiens_hsa052201.89602456
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.89242802
25Propanoate metabolism_Homo sapiens_hsa006401.86971090
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.86844514
27Chemical carcinogenesis_Homo sapiens_hsa052041.86326097
28PPAR signaling pathway_Homo sapiens_hsa033201.85749494
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.78688330
30Staphylococcus aureus infection_Homo sapiens_hsa051501.78077333
31Selenocompound metabolism_Homo sapiens_hsa004501.75515457
32* Pancreatic cancer_Homo sapiens_hsa052121.71478113
33DNA replication_Homo sapiens_hsa030301.71283746
34beta-Alanine metabolism_Homo sapiens_hsa004101.70228056
35Fatty acid metabolism_Homo sapiens_hsa012121.69575705
36Non-small cell lung cancer_Homo sapiens_hsa052231.68817719
37Retinol metabolism_Homo sapiens_hsa008301.67343860
38Thyroid cancer_Homo sapiens_hsa052161.65294124
39Caffeine metabolism_Homo sapiens_hsa002321.63306823
40Bile secretion_Homo sapiens_hsa049761.58358089
41Steroid biosynthesis_Homo sapiens_hsa001001.54978789
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52738065
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.50394557
44RNA transport_Homo sapiens_hsa030131.47230032
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.46580131
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.43656771
47Mismatch repair_Homo sapiens_hsa034301.42855721
48Starch and sucrose metabolism_Homo sapiens_hsa005001.42090255
49* Measles_Homo sapiens_hsa051621.41154324
50ABC transporters_Homo sapiens_hsa020101.39064693
51mRNA surveillance pathway_Homo sapiens_hsa030151.38595545
52* Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37866713
53Viral carcinogenesis_Homo sapiens_hsa052031.37154276
54Renal cell carcinoma_Homo sapiens_hsa052111.36104680
55* B cell receptor signaling pathway_Homo sapiens_hsa046621.33460348
56* Hepatitis B_Homo sapiens_hsa051611.33294842
57Vitamin digestion and absorption_Homo sapiens_hsa049771.28752535
58* Osteoclast differentiation_Homo sapiens_hsa043801.28397085
59Phenylalanine metabolism_Homo sapiens_hsa003601.27733506
60p53 signaling pathway_Homo sapiens_hsa041151.26010802
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22995048
62Prolactin signaling pathway_Homo sapiens_hsa049171.22042532
63Fat digestion and absorption_Homo sapiens_hsa049751.19600925
64Bladder cancer_Homo sapiens_hsa052191.19404256
65Tyrosine metabolism_Homo sapiens_hsa003501.19133836
66Fatty acid elongation_Homo sapiens_hsa000621.18925711
67* NOD-like receptor signaling pathway_Homo sapiens_hsa046211.18828287
68Pyruvate metabolism_Homo sapiens_hsa006201.18153219
69MicroRNAs in cancer_Homo sapiens_hsa052061.17460801
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.16794413
71* Herpes simplex infection_Homo sapiens_hsa051681.16612368
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16102120
73Influenza A_Homo sapiens_hsa051641.14947929
74Colorectal cancer_Homo sapiens_hsa052101.13813920
75Endometrial cancer_Homo sapiens_hsa052131.13644597
76* Acute myeloid leukemia_Homo sapiens_hsa052211.12618135
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.11695073
78Spliceosome_Homo sapiens_hsa030401.11198483
79Folate biosynthesis_Homo sapiens_hsa007901.09810122
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09543715
81Cysteine and methionine metabolism_Homo sapiens_hsa002701.08093218
82mTOR signaling pathway_Homo sapiens_hsa041501.08060100
83Lysine degradation_Homo sapiens_hsa003101.05195400
84* Small cell lung cancer_Homo sapiens_hsa052221.04504921
85* Apoptosis_Homo sapiens_hsa042101.04117274
86* Shigellosis_Homo sapiens_hsa051311.03530138
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03113294
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02827708
89Circadian rhythm_Homo sapiens_hsa047101.02201010
90* Prostate cancer_Homo sapiens_hsa052151.01779752
91Arginine and proline metabolism_Homo sapiens_hsa003301.01229763
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.98425903
93One carbon pool by folate_Homo sapiens_hsa006700.96826059
94Nucleotide excision repair_Homo sapiens_hsa034200.94577972
95Adherens junction_Homo sapiens_hsa045200.94185492
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93904507
97Tuberculosis_Homo sapiens_hsa051520.93734611
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93054962
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90797391
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.90532203
101Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90202880
102Proteoglycans in cancer_Homo sapiens_hsa052050.89200962
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.88783509
104Sphingolipid metabolism_Homo sapiens_hsa006000.88750119
105* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88509769
106* FoxO signaling pathway_Homo sapiens_hsa040680.88227827
107Inositol phosphate metabolism_Homo sapiens_hsa005620.88113676
108Leishmaniasis_Homo sapiens_hsa051400.87952541
109Salmonella infection_Homo sapiens_hsa051320.87568502
110Biosynthesis of amino acids_Homo sapiens_hsa012300.85522104
111Carbon metabolism_Homo sapiens_hsa012000.84694606
112Cyanoamino acid metabolism_Homo sapiens_hsa004600.84371789
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.83307067
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83113064
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82481846
116Dorso-ventral axis formation_Homo sapiens_hsa043200.82016224
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78352508
118Vitamin B6 metabolism_Homo sapiens_hsa007500.78264784
119Glioma_Homo sapiens_hsa052140.77852093
120Oocyte meiosis_Homo sapiens_hsa041140.77757838
121Glutathione metabolism_Homo sapiens_hsa004800.76154714
122ErbB signaling pathway_Homo sapiens_hsa040120.75324194
123* T cell receptor signaling pathway_Homo sapiens_hsa046600.74155180
124Basal transcription factors_Homo sapiens_hsa030220.71740208
125Glycerolipid metabolism_Homo sapiens_hsa005610.71534777
126RNA degradation_Homo sapiens_hsa030180.71309426
127Insulin signaling pathway_Homo sapiens_hsa049100.70668204
128Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70612765
129* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68973599
130* HTLV-I infection_Homo sapiens_hsa051660.68378556
131Sulfur relay system_Homo sapiens_hsa041220.67903853
132Leukocyte transendothelial migration_Homo sapiens_hsa046700.67515668
133* Toxoplasmosis_Homo sapiens_hsa051450.67022019
134* Epstein-Barr virus infection_Homo sapiens_hsa051690.66883061
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66418323
136Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66358226
137Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64420355
138* Chemokine signaling pathway_Homo sapiens_hsa040620.63230790
139Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60733722
140Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60276344
141TGF-beta signaling pathway_Homo sapiens_hsa043500.59125942
142VEGF signaling pathway_Homo sapiens_hsa043700.56388531
143Fatty acid biosynthesis_Homo sapiens_hsa000610.55364727
144Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44372475
145Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43261418
146Metabolic pathways_Homo sapiens_hsa011000.38595670
147Pentose phosphate pathway_Homo sapiens_hsa000300.38526798
148alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32450784
149Insulin resistance_Homo sapiens_hsa049310.28751668
150Prion diseases_Homo sapiens_hsa050200.27179049
151* Adipocytokine signaling pathway_Homo sapiens_hsa049200.21661532
152Linoleic acid metabolism_Homo sapiens_hsa005910.20739291
153Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16244581
154Glycerophospholipid metabolism_Homo sapiens_hsa005640.13918556
155* NF-kappa B signaling pathway_Homo sapiens_hsa040640.12588738
156Galactose metabolism_Homo sapiens_hsa000520.10347622
157Mineral absorption_Homo sapiens_hsa049780.10035203
158* Hepatitis C_Homo sapiens_hsa051600.04702432
159Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.03145255
160Renin-angiotensin system_Homo sapiens_hsa046140.03048425
161Fructose and mannose metabolism_Homo sapiens_hsa000510.02731474
162Systemic lupus erythematosus_Homo sapiens_hsa053220.01779203
163Intestinal immune network for IgA production_Homo sapiens_hsa04672-3.1869180
164Amoebiasis_Homo sapiens_hsa05146-0.0914600
165* TNF signaling pathway_Homo sapiens_hsa04668-0.0875745
166African trypanosomiasis_Homo sapiens_hsa05143-0.0815370
167Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0782735
168Glucagon signaling pathway_Homo sapiens_hsa04922-0.0766196
169Other glycan degradation_Homo sapiens_hsa00511-0.0718284
170Malaria_Homo sapiens_hsa05144-0.0618921
171Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0538787
172Lysosome_Homo sapiens_hsa04142-0.0522624
173AMPK signaling pathway_Homo sapiens_hsa04152-0.0449515
174Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0448220
175Protein digestion and absorption_Homo sapiens_hsa04974-0.0271080
176Legionellosis_Homo sapiens_hsa05134-0.0187747
177Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0108524
178* RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0067979
179Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0043976
180Citrate cycle (TCA cycle)_Homo sapiens_hsa00020-0.0037971

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