ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pre-miRNA processing (GO:0031054)	9.02742091
2	hyperosmotic salinity response (GO:0042538)	8.53710508
3	negative regulation of cytosolic calcium ion concentration (GO:0051481)	6.31299893
4	vascular smooth muscle contraction (GO:0014829)	5.94256236
5	histone mRNA catabolic process (GO:0071044)	5.71469760
6	regulation of response to osmotic stress (GO:0047484)	5.38346128
7	pteridine-containing compound biosynthetic process (GO:0042559)	5.21592258
8	histone H2A acetylation (GO:0043968)	5.11853671
9	microtubule polymerization or depolymerization (GO:0031109)	5.08114398
10	ncRNA catabolic process (GO:0034661)	5.03525044
11	piRNA metabolic process (GO:0034587)	4.88813706
12	relaxation of smooth muscle (GO:0044557)	4.88782873
13	glyoxylate metabolic process (GO:0046487)	4.65825133
14	pyrimidine nucleobase catabolic process (GO:0006208)	4.60045343
15	hypotonic response (GO:0006971)	4.50175884
16	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	4.49482739
17	water-soluble vitamin biosynthetic process (GO:0042364)	4.47221207
18	sodium ion export (GO:0071436)	4.44806789
19	calcium ion import (GO:0070509)	4.41394412
20	limb bud formation (GO:0060174)	4.22887676
21	positive regulation of amino acid transport (GO:0051957)	4.21170742
22	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	4.18532367
23	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	4.18532367
24	regulation of energy homeostasis (GO:2000505)	3.94119222
25	indole-containing compound catabolic process (GO:0042436)	3.90236252
26	indolalkylamine catabolic process (GO:0046218)	3.90236252
27	tryptophan catabolic process (GO:0006569)	3.90236252
28	histone mRNA metabolic process (GO:0008334)	3.88754858
29	regulation of axon guidance (GO:1902667)	3.67619854
30	nucleobase catabolic process (GO:0046113)	3.67193901
31	histone-serine phosphorylation (GO:0035404)	3.63384353
32	inositol phosphate catabolic process (GO:0071545)	3.57981425
33	relaxation of cardiac muscle (GO:0055119)	3.57738705
34	cellular sodium ion homeostasis (GO:0006883)	3.55746120
35	dendritic spine morphogenesis (GO:0060997)	3.50804085
36	rRNA methylation (GO:0031167)	3.49839219
37	regulation of neuron migration (GO:2001222)	3.49090594
38	central nervous system projection neuron axonogenesis (GO:0021952)	3.47032339
39	DNA methylation involved in gamete generation (GO:0043046)	3.46571011
40	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.44051822
41	post-embryonic morphogenesis (GO:0009886)	3.43689276
42	metallo-sulfur cluster assembly (GO:0031163)	3.41300500
43	iron-sulfur cluster assembly (GO:0016226)	3.41300500
44	spinal cord motor neuron differentiation (GO:0021522)	3.41202745
45	L-serine metabolic process (GO:0006563)	3.34868527
46	glial cell proliferation (GO:0014009)	3.32301774
47	resolution of meiotic recombination intermediates (GO:0000712)	3.25851739
48	positive regulation of microtubule polymerization or depolymerization (GO:0031112)	3.24880060
49	neural tube formation (GO:0001841)	3.24079155
50	regulation of timing of cell differentiation (GO:0048505)	3.23997714
51	regulation of axon extension involved in axon guidance (GO:0048841)	3.21896206
52	tryptophan metabolic process (GO:0006568)	3.21183157
53	embryonic heart tube development (GO:0035050)	3.19875144
54	response to salt stress (GO:0009651)	3.18101300
55	protein polyglutamylation (GO:0018095)	3.17860302
56	replication fork processing (GO:0031297)	3.15036718
57	rRNA modification (GO:0000154)	3.12748890
58	regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)	3.11297147
59	dendrite morphogenesis (GO:0048813)	3.11089803
60	meiotic chromosome segregation (GO:0045132)	3.10699414
61	fatty acid homeostasis (GO:0055089)	3.10645325
62	photoreceptor cell maintenance (GO:0045494)	3.08890131
63	meiotic cell cycle (GO:0051321)	3.08369295
64	cellular response to glucose starvation (GO:0042149)	3.06646113
65	axoneme assembly (GO:0035082)	3.05934489
66	DNA double-strand break processing (GO:0000729)	3.05302160
67	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.04978142
68	DNA damage response, detection of DNA damage (GO:0042769)	3.03302003
69	central nervous system neuron axonogenesis (GO:0021955)	3.02243513
70	cell differentiation in spinal cord (GO:0021515)	3.01934897
71	microtubule anchoring (GO:0034453)	3.01330636
72	positive regulation of protein depolymerization (GO:1901881)	3.00755126
73	regulation of development, heterochronic (GO:0040034)	2.98826711
74	polyol catabolic process (GO:0046174)	2.98516366
75	spliceosomal tri-snRNP complex assembly (GO:0000244)	2.97512978
76	pteridine-containing compound metabolic process (GO:0042558)	2.95801364
77	response to caffeine (GO:0031000)	2.95248594
78	DNA demethylation (GO:0080111)	2.94137753
79	aspartate family amino acid biosynthetic process (GO:0009067)	2.93475144
80	entrainment of circadian clock (GO:0009649)	2.93241791
81	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.92824880
82	single strand break repair (GO:0000012)	2.92270284
83	regulation of T cell chemotaxis (GO:0010819)	2.88360117
84	positive regulation of T cell chemotaxis (GO:0010820)	2.88360117
85	gamma-aminobutyric acid transport (GO:0015812)	2.84876226
86	cerebral cortex neuron differentiation (GO:0021895)	2.84019966
87	histone H2A ubiquitination (GO:0033522)	2.83331579
88	postreplication repair (GO:0006301)	2.83076058
89	carnitine shuttle (GO:0006853)	2.81839961
90	neuronal action potential (GO:0019228)	2.80678270
91	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	2.78400615
92	spinal cord development (GO:0021510)	2.78104077
93	cytoplasmic microtubule organization (GO:0031122)	2.77141797
94	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	2.76908429
95	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	2.75514197
96	DNA deamination (GO:0045006)	2.74810505
97	indolalkylamine metabolic process (GO:0006586)	2.74547968
98	positive regulation of protein complex disassembly (GO:0043243)	2.73566033
99	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.72880592
100	kidney morphogenesis (GO:0060993)	2.71777824

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	4.55677322
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.54199765
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.38721290
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.38431695
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.94850534
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.85951586
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.83451486
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.82354543
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.80793311
10	VDR_22108803_ChIP-Seq_LS180_Human	2.76950966
11	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.52529302
12	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.43107420
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.39339943
14	FUS_26573619_Chip-Seq_HEK293_Human	2.22034430
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.10942153
16	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.10517756
17	EZH2_22144423_ChIP-Seq_EOC_Human	2.09897368
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.08188667
19	HTT_18923047_ChIP-ChIP_STHdh_Human	2.05057126
20	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.02067212
21	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.02067212
22	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.86965040
23	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.83962091
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.81082450
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.78624899
26	P300_19829295_ChIP-Seq_ESCs_Human	1.76864161
27	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.75866548
28	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.74643383
29	GATA1_22025678_ChIP-Seq_K562_Human	1.74101062
30	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.73939858
31	ELK1_19687146_ChIP-ChIP_HELA_Human	1.69948689
32	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.68196663
33	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.64580178
34	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.63849386
35	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.58700411
36	ER_23166858_ChIP-Seq_MCF-7_Human	1.57669082
37	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.53020239
38	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.52538748
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.52538748
40	EWS_26573619_Chip-Seq_HEK293_Human	1.52419048
41	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.49057809
42	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.45519202
43	STAT3_23295773_ChIP-Seq_U87_Human	1.43889255
44	VDR_23849224_ChIP-Seq_CD4+_Human	1.41660652
45	TP53_22573176_ChIP-Seq_HFKS_Human	1.40944429
46	NCOR_22424771_ChIP-Seq_293T_Human	1.39940083
47	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.38734386
48	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.38602116
49	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.38542287
50	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.35780995
51	BCAT_22108803_ChIP-Seq_LS180_Human	1.35292259
52	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.35110001
53	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.33899515
54	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.33176416
55	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.31839245
56	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.31520365
57	RUNX2_22187159_ChIP-Seq_PCA_Human	1.30183822
58	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.24365927
59	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.23993006
60	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.23613390
61	TCF4_23295773_ChIP-Seq_U87_Human	1.23530374
62	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.23343906
63	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.23014256
64	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.22404472
65	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.20407591
66	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.20017499
67	EGR1_19032775_ChIP-ChIP_M12_Human	1.19417183
68	TAF15_26573619_Chip-Seq_HEK293_Human	1.14793773
69	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.14145602
70	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.11754660
71	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.09576239
72	RNF2_27304074_Chip-Seq_NSC_Mouse	1.08750325
73	AR_25329375_ChIP-Seq_VCAP_Human	1.06809629
74	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.06692571
75	JUN_21703547_ChIP-Seq_K562_Human	1.03803237
76	TP53_16413492_ChIP-PET_HCT116_Human	1.03597201
77	REST_21632747_ChIP-Seq_MESCs_Mouse	1.01874631
78	MYC_18940864_ChIP-ChIP_HL60_Human	1.01717975
79	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.00952272
80	NANOG_19829295_ChIP-Seq_ESCs_Human	1.00590284
81	SOX2_19829295_ChIP-Seq_ESCs_Human	1.00590284
82	KDM2B_26808549_Chip-Seq_REH_Human	1.00181673
83	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.98628720
84	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.96658608
85	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.95624004
86	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.95595835
87	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.93798129
88	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.93251722
89	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.92520488
90	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.92520488
91	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.92519283
92	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.90634317
93	TP53_18474530_ChIP-ChIP_U2OS_Human	0.89964420
94	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.89357592
95	HOXB7_26014856_ChIP-Seq_BT474_Human	0.88775184
96	AR_21572438_ChIP-Seq_LNCaP_Human	0.87868828
97	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.87753463
98	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.87730060
99	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.87704441
100	SMAD_19615063_ChIP-ChIP_OVARY_Human	0.86989221

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	7.44136802
2	MP0005423_abnormal_somatic_nervous	6.68156694
3	MP0002735_abnormal_chemical_nociception	3.28676850
4	MP0000569_abnormal_digit_pigmentation	3.12485772
5	MP0004133_heterotaxia	2.93339921
6	MP0003890_abnormal_embryonic-extraembry	2.83167709
7	MP0006276_abnormal_autonomic_nervous	2.70174950
8	MP0004084_abnormal_cardiac_muscle	2.54483663
9	MP0006072_abnormal_retinal_apoptosis	2.50732829
10	MP0005551_abnormal_eye_electrophysiolog	2.43197124
11	MP0001986_abnormal_taste_sensitivity	2.29021157
12	MP0003878_abnormal_ear_physiology	2.16073400
13	MP0005377_hearing/vestibular/ear_phenot	2.16073400
14	MP0003950_abnormal_plasma_membrane	2.10950054
15	MP0002734_abnormal_mechanical_nocicepti	2.01901848
16	MP0006035_abnormal_mitochondrial_morpho	1.93467443
17	MP0002102_abnormal_ear_morphology	1.88657139
18	MP0008775_abnormal_heart_ventricle	1.71996804
19	MP0000015_abnormal_ear_pigmentation	1.70129304
20	MP0005671_abnormal_response_to	1.62552887
21	MP0009278_abnormal_bone_marrow	1.62477967
22	MP0006292_abnormal_olfactory_placode	1.59628421
23	MP0001968_abnormal_touch/_nociception	1.52761460
24	MP0001486_abnormal_startle_reflex	1.51342294
25	MP0002751_abnormal_autonomic_nervous	1.49596004
26	MP0005253_abnormal_eye_physiology	1.46620548
27	MP0002736_abnormal_nociception_after	1.45193195
28	MP0009745_abnormal_behavioral_response	1.39927960
29	MP0001984_abnormal_olfaction	1.37925565
30	MP0004130_abnormal_muscle_cell	1.31502979
31	MP0003183_abnormal_peptide_metabolism	1.30166979
32	MP0004924_abnormal_behavior	1.28716634
33	MP0005386_behavior/neurological_phenoty	1.28716634
34	MP0005645_abnormal_hypothalamus_physiol	1.24212581
35	MP0001299_abnormal_eye_distance/	1.18264560
36	MP0000383_abnormal_hair_follicle	1.17702059
37	MP0008058_abnormal_DNA_repair	1.14411677
38	MP0002234_abnormal_pharynx_morphology	1.13077095
39	MP0003221_abnormal_cardiomyocyte_apopto	1.09718530
40	MP0002282_abnormal_trachea_morphology	1.08676624
41	MP0008872_abnormal_physiological_respon	1.08623045
42	MP0000358_abnormal_cell_content/	1.04373660
43	MP0001485_abnormal_pinna_reflex	1.02486701
44	MP0001970_abnormal_pain_threshold	1.01918022
45	MP0002638_abnormal_pupillary_reflex	1.00972748
46	MP0001919_abnormal_reproductive_system	1.00658237
47	MP0003567_abnormal_fetal_cardiomyocyte	0.99031619
48	MP0001764_abnormal_homeostasis	0.98442589
49	MP0002067_abnormal_sensory_capabilities	0.98191649
50	MP0002876_abnormal_thyroid_physiology	0.97620625
51	MP0002160_abnormal_reproductive_system	0.97592945
52	MP0004036_abnormal_muscle_relaxation	0.97262189
53	MP0001293_anophthalmia	0.96872928
54	MP0004085_abnormal_heartbeat	0.96157817
55	MP0003011_delayed_dark_adaptation	0.94800026
56	MP0008877_abnormal_DNA_methylation	0.92943839
57	MP0003119_abnormal_digestive_system	0.91689538
58	MP0003693_abnormal_embryo_hatching	0.91551498
59	MP0001963_abnormal_hearing_physiology	0.85974111
60	MP0010678_abnormal_skin_adnexa	0.85651355
61	MP0002069_abnormal_eating/drinking_beha	0.83348928
62	MP0005389_reproductive_system_phenotype	0.81115830
63	MP0002752_abnormal_somatic_nervous	0.79802639
64	MP0000467_abnormal_esophagus_morphology	0.79498443
65	MP0005670_abnormal_white_adipose	0.79392716
66	MP0004742_abnormal_vestibular_system	0.78798828
67	MP0005410_abnormal_fertilization	0.77158973
68	MP0001529_abnormal_vocalization	0.77075695
69	MP0002909_abnormal_adrenal_gland	0.76661370
70	MP0003195_calcinosis	0.76512271
71	MP0003635_abnormal_synaptic_transmissio	0.76167093
72	MP0000372_irregular_coat_pigmentation	0.76004693
73	MP0002572_abnormal_emotion/affect_behav	0.75964007
74	MP0003698_abnormal_male_reproductive	0.75067144
75	MP0008932_abnormal_embryonic_tissue	0.74690440
76	MP0005391_vision/eye_phenotype	0.73278093
77	MP0008875_abnormal_xenobiotic_pharmacok	0.72055487
78	MP0002233_abnormal_nose_morphology	0.71664353
79	MP0002163_abnormal_gland_morphology	0.71276786
80	MP0005174_abnormal_tail_pigmentation	0.70479865
81	MP0005195_abnormal_posterior_eye	0.70026505
82	MP0000631_abnormal_neuroendocrine_gland	0.69988454
83	MP0002272_abnormal_nervous_system	0.69901362
84	MP0003938_abnormal_ear_development	0.69873010
85	MP0002229_neurodegeneration	0.69187588
86	MP0002095_abnormal_skin_pigmentation	0.67587995
87	MP0001929_abnormal_gametogenesis	0.67365911
88	MP0002090_abnormal_vision	0.64008675
89	MP0002210_abnormal_sex_determination	0.62569272
90	MP0001501_abnormal_sleep_pattern	0.62071015
91	MP0002177_abnormal_outer_ear	0.61430027
92	MP0004142_abnormal_muscle_tone	0.60525839
93	MP0003937_abnormal_limbs/digits/tail_de	0.60298017
94	MP0005085_abnormal_gallbladder_physiolo	0.59107728
95	MP0004215_abnormal_myocardial_fiber	0.57718447
96	MP0000516_abnormal_urinary_system	0.57230084
97	MP0005367_renal/urinary_system_phenotyp	0.57230084
98	MP0002064_seizures	0.57088981
99	MP0003136_yellow_coat_color	0.56682725
100	MP0005332_abnormal_amino_acid	0.56532353

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Carpal bone hypoplasia (HP:0001498)	6.61091882
2	Hip dysplasia (HP:0001385)	5.78759911
3	Hip contracture (HP:0003273)	5.76498968
4	Fetal akinesia sequence (HP:0001989)	5.62620039
5	Spinal muscular atrophy (HP:0007269)	5.60087538
6	Aplasia of the musculature (HP:0100854)	5.18889948
7	Diaphragmatic weakness (HP:0009113)	5.06269498
8	Abnormality of the middle phalanges of the toes (HP:0010183)	4.93670979
9	Muscle fiber splitting (HP:0003555)	4.79219677
10	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	4.45457194
11	Aplasia/Hypoplasia involving the musculature (HP:0001460)	4.31438770
12	Stridor (HP:0010307)	4.27039041
13	Hand muscle atrophy (HP:0009130)	3.99437888
14	Disproportionate short-trunk short stature (HP:0003521)	3.98833436
15	Limited hip movement (HP:0008800)	3.92376996
16	Supernumerary spleens (HP:0009799)	3.77099522
17	Obstructive sleep apnea (HP:0002870)	3.68824329
18	Hypoplasia of the odontoid process (HP:0003311)	3.67343489
19	Flat acetabular roof (HP:0003180)	3.57786263
20	Methylmalonic acidemia (HP:0002912)	3.51278629
21	Barrel-shaped chest (HP:0001552)	3.49509967
22	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	3.45853362
23	Broad-based gait (HP:0002136)	3.41333408
24	True hermaphroditism (HP:0010459)	3.38741823
25	Down-sloping shoulders (HP:0200021)	3.35133949
26	Abnormality of the vocal cords (HP:0008777)	3.35115327
27	Difficulty running (HP:0009046)	3.31360188
28	Limb-girdle muscle atrophy (HP:0003797)	3.29610845
29	Distal lower limb muscle weakness (HP:0009053)	3.20426590
30	Pancreatic cysts (HP:0001737)	3.17758775
31	Epiphyseal dysplasia (HP:0002656)	3.15935160
32	Abnormality of the distal phalanges of the toes (HP:0010182)	3.13852443
33	Spinal cord compression (HP:0002176)	3.07238307
34	Abnormality of the vitamin B12 metabolism (HP:0004341)	3.01738790
35	Abnormality of the odontoid process (HP:0003310)	2.91748009
36	Small hand (HP:0200055)	2.91448992
37	Distal upper limb amyotrophy (HP:0007149)	2.88842725
38	Upper limb amyotrophy (HP:0009129)	2.88842725
39	Pancreatic fibrosis (HP:0100732)	2.88022942
40	Short femoral neck (HP:0100864)	2.79420408
41	Abnormality of the intervertebral disk (HP:0005108)	2.78265023
42	Short tibia (HP:0005736)	2.76776039
43	Abnormality of vitamin B metabolism (HP:0004340)	2.76710368
44	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.69501349
45	Knee flexion contracture (HP:0006380)	2.66625779
46	Methylmalonic aciduria (HP:0012120)	2.65457840
47	Anencephaly (HP:0002323)	2.65354782
48	Sleep apnea (HP:0010535)	2.62737182
49	Abnormal vertebral ossification (HP:0100569)	2.61860768
50	Metaphyseal irregularity (HP:0003025)	2.59577264
51	Lower limb asymmetry (HP:0100559)	2.54818629
52	Scapular winging (HP:0003691)	2.47503804
53	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	2.42145053
54	Meckel diverticulum (HP:0002245)	2.39587561
55	Gowers sign (HP:0003391)	2.38869335
56	Nonprogressive disorder (HP:0003680)	2.34556396
57	Abnormality of the calf musculature (HP:0001430)	2.30757445
58	Abnormality of the ileum (HP:0001549)	2.30507525
59	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.29740314
60	Abnormality of carpal bone ossification (HP:0006257)	2.29737439
61	Abnormality of midbrain morphology (HP:0002418)	2.23623194
62	Molar tooth sign on MRI (HP:0002419)	2.23623194
63	Abnormality of DNA repair (HP:0003254)	2.23072420
64	Absent septum pellucidum (HP:0001331)	2.18003358
65	Abnormality of the preputium (HP:0100587)	2.16058832
66	Cystic liver disease (HP:0006706)	2.14635365
67	Tubulointerstitial nephritis (HP:0001970)	2.10499858
68	Colon cancer (HP:0003003)	2.07361990
69	Abnormal lung lobation (HP:0002101)	2.06936736
70	Preaxial hand polydactyly (HP:0001177)	2.06563352
71	Torticollis (HP:0000473)	2.05592300
72	Urinary urgency (HP:0000012)	2.04833965
73	Cortical dysplasia (HP:0002539)	2.03806099
74	Renal cortical cysts (HP:0000803)	2.03744210
75	Hyperglycinemia (HP:0002154)	2.02951391
76	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.02646774
77	Progressive inability to walk (HP:0002505)	2.00801481
78	Congenital stationary night blindness (HP:0007642)	1.96450710
79	Proximal amyotrophy (HP:0007126)	1.94564192
80	Abnormality of the renal cortex (HP:0011035)	1.93511671
81	Tubulointerstitial abnormality (HP:0001969)	1.90502173
82	Abnormality of vitamin metabolism (HP:0100508)	1.87760252
83	Rough bone trabeculation (HP:0100670)	1.87520944
84	Abnormality of the septum pellucidum (HP:0007375)	1.86700231
85	Abnormality of serine family amino acid metabolism (HP:0010894)	1.82505464
86	Abnormality of glycine metabolism (HP:0010895)	1.82505464
87	Midline defect of the nose (HP:0004122)	1.81787253
88	Abnormality of the shoulder girdle musculature (HP:0001435)	1.80029252
89	Short middle phalanx of finger (HP:0005819)	1.79652382
90	Aplasia/Hypoplasia involving the vertebral column (HP:0008518)	1.79346838
91	Abnormality of chromosome stability (HP:0003220)	1.78882420
92	Abnormal hand bone ossification (HP:0010660)	1.77447748
93	Waddling gait (HP:0002515)	1.76100725
94	Aplasia/hypoplasia of the femur (HP:0005613)	1.75718164
95	Sclerocornea (HP:0000647)	1.75343553
96	Metatarsus adductus (HP:0001840)	1.74585829
97	Abnormality of the renal medulla (HP:0100957)	1.73561190
98	Postaxial foot polydactyly (HP:0001830)	1.71016121
99	Abnormality of the labia minora (HP:0012880)	1.70305000
100	Hypoproteinemia (HP:0003075)	1.69815670

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	4.39625616
2	IRAK1	3.71256233
3	IRAK2	3.60114778
4	MAP4K2	3.20120311
5	CLK1	3.11920290
6	FRK	2.74336190
7	ZAK	2.45451513
8	WNK4	2.24896694
9	STK39	1.98723924
10	ADRBK2	1.98583061
11	WNK3	1.96962765
12	MAP2K7	1.96567451
13	MAPK13	1.94337138
14	DYRK2	1.92159958
15	TTK	1.85258753
16	BMPR1B	1.83702651
17	SRPK1	1.80679056
18	VRK1	1.75822530
19	OXSR1	1.73785242
20	MAP3K7	1.71026988
21	PLK2	1.59770078
22	CDC7	1.59041148
23	PLK4	1.58122255
24	PLK3	1.53396902
25	NUAK1	1.53113734
26	RPS6KA4	1.52877192
27	YES1	1.51569484
28	CASK	1.44230716
29	MAP3K4	1.41757769
30	FER	1.39166585
31	TIE1	1.35563274
32	TRIM28	1.35447143
33	BRSK2	1.29141001
34	CCNB1	1.22358861
35	TNIK	1.12861416
36	STK4	1.11968706
37	EPHA4	1.10247402
38	MST4	1.08110001
39	ACVR1B	1.02113212
40	TLK1	0.97919698
41	MKNK2	0.93190413
42	BRSK1	0.92229006
43	EIF2AK3	0.91527511
44	CDK3	0.91197426
45	TSSK6	0.87346801
46	KDR	0.83959764
47	TXK	0.83425367
48	MAP3K9	0.83068314
49	GRK1	0.78520177
50	CHEK2	0.77003753
51	STK3	0.74434646
52	FES	0.73773637
53	STK11	0.69080913
54	INSRR	0.68344699
55	GRK7	0.67300535
56	PRKCE	0.67147265
57	CSNK1G1	0.66719120
58	TNK2	0.66446689
59	RPS6KB2	0.65943734
60	MKNK1	0.62899605
61	PLK1	0.59917773
62	PRKAA2	0.58785695
63	SGK1	0.57500958
64	LYN	0.56236801
65	TAF1	0.55900199
66	TGFBR1	0.54426693
67	EPHA3	0.53984872
68	TEC	0.52696623
69	FGFR2	0.51875171
70	PINK1	0.51258029
71	PRKAA1	0.50888345
72	ATM	0.49688391
73	MINK1	0.48661081
74	BCR	0.47746080
75	CDK18	0.46515276
76	EIF2AK1	0.46442830
77	VRK2	0.44553817
78	CDK15	0.44084727
79	CDK1	0.43894819
80	MUSK	0.43398945
81	CAMK1	0.42569849
82	CDK5	0.40695542
83	CAMKK2	0.39915413
84	STK38	0.39848071
85	PKN1	0.39418278
86	BRD4	0.38535195
87	STK16	0.38374930
88	BUB1	0.36588036
89	ROCK1	0.36078270
90	IGF1R	0.35230655
91	MAP3K12	0.34825612
92	CSNK1G2	0.34772384
93	CDK11A	0.34380280
94	ARAF	0.32530439
95	RPS6KA5	0.32391491
96	CSNK1E	0.31788264
97	OBSCN	0.31179641
98	GSK3B	0.30541246
99	CSNK1G3	0.30507467
100	PRKACA	0.29305094

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	2.91390861
2	Regulation of autophagy_Homo sapiens_hsa04140	2.83337179
3	Propanoate metabolism_Homo sapiens_hsa00640	2.75573956
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.41025740
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.22063649
6	Fanconi anemia pathway_Homo sapiens_hsa03460	2.19790870
7	Phototransduction_Homo sapiens_hsa04744	2.18939400
8	Non-homologous end-joining_Homo sapiens_hsa03450	2.15480877
9	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.05888721
10	Basal transcription factors_Homo sapiens_hsa03022	2.01642276
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.00252396
12	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.91792019
13	RNA polymerase_Homo sapiens_hsa03020	1.90141415
14	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.88657346
15	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.85799423
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.84099240
17	Tryptophan metabolism_Homo sapiens_hsa00380	1.81868374
18	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.75638519
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.69531902
20	Nicotine addiction_Homo sapiens_hsa05033	1.59929592
21	Homologous recombination_Homo sapiens_hsa03440	1.58419641
22	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.55267469
23	RNA degradation_Homo sapiens_hsa03018	1.50687286
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.48034445
25	Circadian rhythm_Homo sapiens_hsa04710	1.43037045
26	Caffeine metabolism_Homo sapiens_hsa00232	1.38728907
27	Base excision repair_Homo sapiens_hsa03410	1.37293863
28	Butanoate metabolism_Homo sapiens_hsa00650	1.35677319
29	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.33064659
30	ABC transporters_Homo sapiens_hsa02010	1.32665821
31	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.29031362
32	Olfactory transduction_Homo sapiens_hsa04740	1.28724852
33	Primary immunodeficiency_Homo sapiens_hsa05340	1.28428721
34	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.27500662
35	Mineral absorption_Homo sapiens_hsa04978	1.22742436
36	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.22676398
37	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.22474877
38	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.14715797
39	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.13822141
40	Retinol metabolism_Homo sapiens_hsa00830	1.11524669
41	Nucleotide excision repair_Homo sapiens_hsa03420	1.11039238
42	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.10071352
43	Nitrogen metabolism_Homo sapiens_hsa00910	1.09919408
44	Mismatch repair_Homo sapiens_hsa03430	1.07871814
45	Parkinsons disease_Homo sapiens_hsa05012	1.07081846
46	Oxidative phosphorylation_Homo sapiens_hsa00190	1.05734080
47	Protein export_Homo sapiens_hsa03060	1.02334176
48	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.02087489
49	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.95135472
50	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.92491332
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.91759156
52	beta-Alanine metabolism_Homo sapiens_hsa00410	0.91390718
53	Chemical carcinogenesis_Homo sapiens_hsa05204	0.91188471
54	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.89421998
55	One carbon pool by folate_Homo sapiens_hsa00670	0.89397443
56	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.88814557
57	Fatty acid metabolism_Homo sapiens_hsa01212	0.87096939
58	Taste transduction_Homo sapiens_hsa04742	0.86094639
59	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.84916963
60	Arginine and proline metabolism_Homo sapiens_hsa00330	0.84226790
61	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.82506909
62	Peroxisome_Homo sapiens_hsa04146	0.82368868
63	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.82243539
64	Protein digestion and absorption_Homo sapiens_hsa04974	0.82094661
65	Steroid biosynthesis_Homo sapiens_hsa00100	0.81557793
66	RNA transport_Homo sapiens_hsa03013	0.80126047
67	Ether lipid metabolism_Homo sapiens_hsa00565	0.78535849
68	Fatty acid elongation_Homo sapiens_hsa00062	0.76354601
69	Spliceosome_Homo sapiens_hsa03040	0.76344247
70	GABAergic synapse_Homo sapiens_hsa04727	0.75954196
71	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.75109468
72	Histidine metabolism_Homo sapiens_hsa00340	0.74922185
73	Fat digestion and absorption_Homo sapiens_hsa04975	0.73395805
74	Fatty acid degradation_Homo sapiens_hsa00071	0.72552396
75	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.70326509
76	Huntingtons disease_Homo sapiens_hsa05016	0.67766612
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.65735191
78	Purine metabolism_Homo sapiens_hsa00230	0.64791436
79	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.64625718
80	Alzheimers disease_Homo sapiens_hsa05010	0.63302692
81	Metabolic pathways_Homo sapiens_hsa01100	0.59463602
82	Carbon metabolism_Homo sapiens_hsa01200	0.58686362
83	Pyrimidine metabolism_Homo sapiens_hsa00240	0.58021030
84	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.57828456
85	Glycerolipid metabolism_Homo sapiens_hsa00561	0.52701015
86	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.51839556
87	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.45565733
88	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.45341791
89	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.44091867
90	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.43562413
91	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.43412083
92	Graft-versus-host disease_Homo sapiens_hsa05332	0.43168541
93	Glutathione metabolism_Homo sapiens_hsa00480	0.42724481
94	mRNA surveillance pathway_Homo sapiens_hsa03015	0.41294067
95	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.41148917
96	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.39767423
97	Antigen processing and presentation_Homo sapiens_hsa04612	0.39564139
98	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.38769589
99	Pyruvate metabolism_Homo sapiens_hsa00620	0.38588584
100	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.37694174

CIAPIN1P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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