CIB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the EF-hand domain-containing calcium-binding superfamily. The encoded protein interacts with many other proteins, including the platelet integrin alpha-IIb-beta-3, DNA-dependent protein kinase, presenilin-2, focal adhesion kinase, p21 activated kinase, and protein kinase D. The encoded protein may be involved in cell survival and proliferation, and is associated with several disease states including cancer and Alzheimer's disease. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)7.32893095
2cilium or flagellum-dependent cell motility (GO:0001539)5.32230988
3motile cilium assembly (GO:0044458)5.02522848
4cilium movement (GO:0003341)4.40061833
5tolerance induction (GO:0002507)4.18444299
6ribosomal small subunit assembly (GO:0000028)3.72364364
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.71843896
8epithelial cilium movement (GO:0003351)3.58051937
9DNA deamination (GO:0045006)3.57966184
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.48211666
11negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.24380804
12positive regulation of tolerance induction (GO:0002645)3.21448306
13diterpenoid biosynthetic process (GO:0016102)3.18216343
14axoneme assembly (GO:0035082)3.14896038
15sulfur amino acid catabolic process (GO:0000098)3.10008652
16regulation of tolerance induction (GO:0002643)3.02037977
17immunoglobulin mediated immune response (GO:0016064)2.97083498
18viral transcription (GO:0019083)2.95708853
19hydrogen peroxide biosynthetic process (GO:0050665)2.94467137
20cysteine metabolic process (GO:0006534)2.89131031
21antigen processing and presentation of endogenous antigen (GO:0019883)2.87414667
22pyrimidine-containing compound transmembrane transport (GO:0072531)2.86935389
23translational termination (GO:0006415)2.85863279
24Golgi transport vesicle coating (GO:0048200)2.85535847
25COPI coating of Golgi vesicle (GO:0048205)2.85535847
26aldehyde catabolic process (GO:0046185)2.81557001
27SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.80219350
28cytidine deamination (GO:0009972)2.77124751
29cytidine metabolic process (GO:0046087)2.77124751
30cytidine catabolic process (GO:0006216)2.77124751
31NIK/NF-kappaB signaling (GO:0038061)2.76265633
32antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.74224803
33antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.74224803
34reactive oxygen species biosynthetic process (GO:1903409)2.72402392
35protein targeting to ER (GO:0045047)2.70254953
36ribosomal small subunit biogenesis (GO:0042274)2.70020657
37negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.69519616
38cotranslational protein targeting to membrane (GO:0006613)2.68992741
39regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.68261470
40response to nitrosative stress (GO:0051409)2.67293043
41left/right pattern formation (GO:0060972)2.65439302
42neutrophil activation involved in immune response (GO:0002283)2.64089502
43negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.63741215
44negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.63442287
45negative regulation of cell killing (GO:0031342)2.63442287
46folic acid metabolic process (GO:0046655)2.61744868
47translational elongation (GO:0006414)2.59454019
48regulation of RIG-I signaling pathway (GO:0039535)2.59437791
49cellular response to type I interferon (GO:0071357)2.59080840
50type I interferon signaling pathway (GO:0060337)2.59080840
51drug transport (GO:0015893)2.58685574
52response to type I interferon (GO:0034340)2.58630894
53protein localization to endoplasmic reticulum (GO:0070972)2.58361462
54GDP-mannose metabolic process (GO:0019673)2.58243430
55drug transmembrane transport (GO:0006855)2.57125653
56positive regulation of gamma-delta T cell activation (GO:0046645)2.57117219
57lipoxygenase pathway (GO:0019372)2.56565508
58response to interferon-beta (GO:0035456)2.55731058
59detection of bacterium (GO:0016045)2.55352778
60L-phenylalanine metabolic process (GO:0006558)2.55249601
61erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.55249601
62urate metabolic process (GO:0046415)2.55016362
63glucuronate metabolic process (GO:0019585)2.54287367
64uronic acid metabolic process (GO:0006063)2.54287367
65cellular glucuronidation (GO:0052695)2.53650753
66ribosomal large subunit biogenesis (GO:0042273)2.52287565
67proteasome assembly (GO:0043248)2.51894296
68response to xenobiotic stimulus (GO:0009410)2.51867243
69proline metabolic process (GO:0006560)2.51277066
70homocysteine metabolic process (GO:0050667)2.51265896
71flavonoid metabolic process (GO:0009812)2.49977306
72establishment of protein localization to endoplasmic reticulum (GO:0072599)2.49445695
73maturation of SSU-rRNA (GO:0030490)2.48735310
74fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.48068490
75serine family amino acid biosynthetic process (GO:0009070)2.44064903
76positive regulation of Cdc42 GTPase activity (GO:0043089)2.43475438
77antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.41392587
78regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.41053438
79antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.40681232
80regulation of respiratory burst (GO:0060263)2.40402998
81hydrogen peroxide catabolic process (GO:0042744)2.40145283
82glyoxylate metabolic process (GO:0046487)2.39946416
83negative regulation of T cell differentiation in thymus (GO:0033085)2.39397214
84regulation of germinal center formation (GO:0002634)2.39366562
85T cell apoptotic process (GO:0070231)2.38765159
86primary alcohol catabolic process (GO:0034310)2.38726601
87glutathione derivative biosynthetic process (GO:1901687)2.37385543
88glutathione derivative metabolic process (GO:1901685)2.37385543
89urea metabolic process (GO:0019627)2.36981825
90urea cycle (GO:0000050)2.36981825
91response to peptidoglycan (GO:0032494)2.36042582
92pyrimidine ribonucleoside catabolic process (GO:0046133)2.35769641
93aromatic amino acid family catabolic process (GO:0009074)2.34205118
94indolalkylamine catabolic process (GO:0046218)2.34114430
95tryptophan catabolic process (GO:0006569)2.34114430
96indole-containing compound catabolic process (GO:0042436)2.34114430
97detection of other organism (GO:0098543)2.33959964
98vitamin transmembrane transport (GO:0035461)2.33754186
99serine family amino acid metabolic process (GO:0009069)2.32141794
100negative regulation of stress fiber assembly (GO:0051497)2.31957228
101positive regulation of T cell mediated cytotoxicity (GO:0001916)2.31761018
102L-phenylalanine catabolic process (GO:0006559)2.31493103
103erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.31493103
104positive regulation of triglyceride lipase activity (GO:0061365)2.31371670
105positive regulation of lipoprotein lipase activity (GO:0051006)2.31371670
106cellular response to interferon-beta (GO:0035458)2.31267305
107translational initiation (GO:0006413)2.30969992
108negative regulation of humoral immune response (GO:0002921)2.30750334
109regulation of cilium movement (GO:0003352)2.30467178
110lipopolysaccharide-mediated signaling pathway (GO:0031663)2.30429458
111leukocyte apoptotic process (GO:0071887)2.30335003
112viral life cycle (GO:0019058)2.29935720
113bile acid and bile salt transport (GO:0015721)2.29536546
114intestinal absorption (GO:0050892)2.29372193
115nucleoside salvage (GO:0043174)2.29015766
116glutathione biosynthetic process (GO:0006750)2.28850453
117xenobiotic catabolic process (GO:0042178)2.28826615
118proline biosynthetic process (GO:0006561)2.28689302
119glycine metabolic process (GO:0006544)2.27328502
120Arp2/3 complex-mediated actin nucleation (GO:0034314)2.27020555
121interferon-gamma-mediated signaling pathway (GO:0060333)2.26750191
122B cell mediated immunity (GO:0019724)2.26614592
123peptide catabolic process (GO:0043171)2.26246316
124nitrogen cycle metabolic process (GO:0071941)2.25973707
125pentose metabolic process (GO:0019321)2.25799245
126regulation of alpha-beta T cell proliferation (GO:0046640)2.25588691
127hepatocyte apoptotic process (GO:0097284)2.25231652
128cellular response to zinc ion (GO:0071294)2.25186873
129lymphocyte apoptotic process (GO:0070227)2.23007528
130ethanol metabolic process (GO:0006067)2.22966374
131positive regulation of endothelial cell apoptotic process (GO:2000353)2.22920552
132telomere maintenance via semi-conservative replication (GO:0032201)2.21810488
133autophagic vacuole fusion (GO:0000046)2.21058451
134regulation of autophagic vacuole assembly (GO:2000785)2.20668435
135serine family amino acid catabolic process (GO:0009071)2.20469472
136tryptophan metabolic process (GO:0006568)2.19981654
137regulation of antigen processing and presentation (GO:0002577)2.19975332
138oxidative phosphorylation (GO:0006119)2.19273626
139regulation of gamma-delta T cell activation (GO:0046643)2.18630041
140negative regulation of lymphocyte mediated immunity (GO:0002707)2.18577190
141pteridine-containing compound biosynthetic process (GO:0042559)2.18097844
142nucleotide-sugar biosynthetic process (GO:0009226)2.17948424
143formation of translation preinitiation complex (GO:0001731)2.16780133
144one-carbon compound transport (GO:0019755)2.16142531
145glutathione metabolic process (GO:0006749)2.16060013
146positive regulation of interleukin-17 production (GO:0032740)2.16039605
147leukocyte aggregation (GO:0070486)2.15564894
148translation (GO:0006412)2.15136214
149mature B cell differentiation involved in immune response (GO:0002313)2.15019063
150regulation of superoxide anion generation (GO:0032928)2.14727758
151regulation of gamma-delta T cell differentiation (GO:0045586)2.14568539
152regulation of regulatory T cell differentiation (GO:0045589)2.14427241
153phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.13808991
154amino-acid betaine metabolic process (GO:0006577)2.13201451
155protein maturation by protein folding (GO:0022417)2.13180728
156folic acid-containing compound biosynthetic process (GO:0009396)2.12873527
157signal peptide processing (GO:0006465)2.12772960
158UDP-N-acetylglucosamine metabolic process (GO:0006047)2.12688324
159nonribosomal peptide biosynthetic process (GO:0019184)2.12592941
160positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.12474671
161regulation of T cell mediated cytotoxicity (GO:0001914)2.12266813
162regulation of dendritic cell antigen processing and presentation (GO:0002604)2.12196407
163regulation of cellular amino acid metabolic process (GO:0006521)2.11648663
164cellular protein complex disassembly (GO:0043624)2.11597842
165calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.10968879
166T-helper 1 type immune response (GO:0042088)2.10911291
167ethanol oxidation (GO:0006069)2.10633175
168tumor necrosis factor-mediated signaling pathway (GO:0033209)2.09880913
169hydrogen peroxide metabolic process (GO:0042743)2.09736727
170DNA strand elongation involved in DNA replication (GO:0006271)2.09398980
171negative regulation of leukocyte mediated immunity (GO:0002704)2.08863785
172pantothenate metabolic process (GO:0015939)2.07885192
173nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.07494849
174primary alcohol metabolic process (GO:0034308)2.07346409
175deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.07078286
176renal absorption (GO:0070293)2.06396317
177organic cation transport (GO:0015695)2.05610897
178positive regulation of antigen processing and presentation (GO:0002579)2.04504185
179sulfur amino acid metabolic process (GO:0000096)2.03705223
180pentose-phosphate shunt (GO:0006098)2.03377585
181regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.02877382
182antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.02839884

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.48218670
2E2F7_22180533_ChIP-Seq_HELA_Human3.32788542
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.90295640
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.74985686
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.64884562
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.57876699
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.51670742
8RXR_22158963_ChIP-Seq_LIVER_Mouse2.45463841
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.40718636
10EGR1_23403033_ChIP-Seq_LIVER_Mouse2.35376217
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.29656779
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.29407021
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.10929221
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.06607613
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.05781087
16ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93606389
17LXR_22292898_ChIP-Seq_THP-1_Human1.93164416
18MYC_18358816_ChIP-ChIP_MESCs_Mouse1.89581850
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.80345701
20IRF8_21731497_ChIP-ChIP_J774_Mouse1.79650851
21CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77966753
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.77509645
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.77337570
24HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.76867269
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.76750627
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.73541793
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.71802634
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.71790552
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.71591963
30STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.70696765
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.69327302
32RACK7_27058665_Chip-Seq_MCF-7_Human1.66061637
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.65276339
34ZNF263_19887448_ChIP-Seq_K562_Human1.63813814
35LXR_22158963_ChIP-Seq_LIVER_Mouse1.60186126
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.60114430
37ELF1_20517297_ChIP-Seq_JURKAT_Human1.58688859
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.57183079
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.56694883
40BCL6_27268052_Chip-Seq_Bcells_Human1.56590005
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56503324
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54419309
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.53650934
44BCOR_27268052_Chip-Seq_Bcells_Human1.51381352
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.50371071
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47483276
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.46804194
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.45264839
49DCP1A_22483619_ChIP-Seq_HELA_Human1.43491850
50VDR_23849224_ChIP-Seq_CD4+_Human1.42279571
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.41280796
52AR_21909140_ChIP-Seq_LNCAP_Human1.41266334
53STAT1_20625510_ChIP-Seq_HELA_Human1.38914005
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.37879957
55PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36732753
56NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36467829
57XRN2_22483619_ChIP-Seq_HELA_Human1.36143705
58P68_20966046_ChIP-Seq_HELA_Human1.35058495
59* UTX_26944678_Chip-Seq_JUKART_Human1.33918414
60MAF_26560356_Chip-Seq_TH2_Human1.33808384
61MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33687171
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.31308110
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31174840
64CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30150917
65TRIM28_21343339_ChIP-Seq_HEK293_Human1.29613761
66SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29226277
67RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28747108
68P63_26484246_Chip-Seq_KERATINOCYTES_Human1.27886722
69STAT4_19710469_ChIP-ChIP_TH1__Mouse1.27873866
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.27681540
71* SPI1_23547873_ChIP-Seq_NB4_Human1.27209456
72MYB_21317192_ChIP-Seq_ERMYB_Mouse1.26078137
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25720226
74CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.22974630
75ESR2_21235772_ChIP-Seq_MCF-7_Human1.22949985
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22270427
77MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.22262766
78* SA1_27219007_Chip-Seq_ERYTHROID_Human1.22224647
79TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.21684511
80CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.19874919
81* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19163204
82BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19065800
83SPI1_23127762_ChIP-Seq_K562_Human1.18486810
84FOXP3_21729870_ChIP-Seq_TREG_Human1.17889719
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17306320
86SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.17117374
87GABP_19822575_ChIP-Seq_HepG2_Human1.17029921
88CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16289331
89CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16172794
90PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15048091
91TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15027183
92VDR_21846776_ChIP-Seq_THP-1_Human1.14904731
93GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14422858
94P300_27268052_Chip-Seq_Bcells_Human1.14226707
95NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14185698
96E2F1_20622854_ChIP-Seq_HELA_Human1.14076817
97GATA4_25053715_ChIP-Seq_YYC3_Human1.13982897
98FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.13575621
99MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.12591892
100PHF8_20622854_ChIP-Seq_HELA_Human1.12177600
101CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12174678
102SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12162352
103SOX2_27498859_Chip-Seq_STOMACH_Mouse1.11699752
104ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10752080
105GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10307101
106SMC4_20622854_ChIP-Seq_HELA_Human1.09974050
107RUNX_20019798_ChIP-Seq_JUKART_Human1.09752727
108YY1_22570637_ChIP-Seq_MALME-3M_Human1.09582147
109E2F4_17652178_ChIP-ChIP_JURKAT_Human1.09564503
110CDX2_20551321_ChIP-Seq_CACO-2_Human1.09415827
111* MYB_26560356_Chip-Seq_TH1_Human1.09032629
112CTCF_20526341_ChIP-Seq_ESCs_Human1.08850062
113ATF3_27146783_Chip-Seq_COLON_Human1.08351292
114FOXM1_23109430_ChIP-Seq_U2OS_Human1.08030785
115KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07555146
116ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06537225
117LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05626586
118SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04794000
119RUNX1_27514584_Chip-Seq_MCF-7_Human1.04598976
120FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.04053652
121TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03830036
122NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02838792
123CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02185336
124ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.01237021
125SA1_27219007_Chip-Seq_Bcells_Human1.01165683
126CTCF_26484167_Chip-Seq_Bcells_Mouse1.00614140
127YY1_21170310_ChIP-Seq_MESCs_Mouse1.00588176
128GATA6_25053715_ChIP-Seq_YYC3_Human0.99845074
129RUNX1_22412390_ChIP-Seq_EML_Mouse0.99773064
130IRF8_27001747_Chip-Seq_BMDM_Mouse0.99017574
131HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98504772
132CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97799593
133PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96749891
134RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94285745
135NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.93501425
136EGR1_19374776_ChIP-ChIP_THP-1_Human0.92527975
137GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92242313
138MYC_22102868_ChIP-Seq_BL_Human0.91384391
139FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.91227431
140VDR_24763502_ChIP-Seq_THP-1_Human0.90373654
141HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.89940818
142MYB_26560356_Chip-Seq_TH2_Human0.89889329
143SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89560199
144POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89257628
145* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88906363
146PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88267498
147PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87975105
148MAF_26560356_Chip-Seq_TH1_Human0.87624148

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis3.94594691
2MP0002139_abnormal_hepatobiliary_system3.30848802
3MP0003806_abnormal_nucleotide_metabolis2.97544501
4MP0003693_abnormal_embryo_hatching2.54832094
5MP0005085_abnormal_gallbladder_physiolo2.44497150
6MP0003186_abnormal_redox_activity2.32540199
7MP0005365_abnormal_bile_salt2.25597245
8MP0001835_abnormal_antigen_presentation2.23441513
9MP0008875_abnormal_xenobiotic_pharmacok2.14955192
10MP0009840_abnormal_foam_cell2.06132745
11MP0009785_altered_susceptibility_to1.97310428
12MP0002138_abnormal_hepatobiliary_system1.96767302
13MP0010155_abnormal_intestine_physiology1.87256742
14MP0000685_abnormal_immune_system1.85815740
15MP0000465_gastrointestinal_hemorrhage1.82861604
16MP0003252_abnormal_bile_duct1.81557335
17MP0003191_abnormal_cellular_cholesterol1.81476313
18MP0001873_stomach_inflammation1.80013121
19MP0009643_abnormal_urine_homeostasis1.77300538
20MP0001666_abnormal_nutrient_absorption1.75690477
21MP0000490_abnormal_crypts_of1.74482050
22MP0004019_abnormal_vitamin_homeostasis1.73710586
23MP0003303_peritoneal_inflammation1.73534541
24MP0005332_abnormal_amino_acid1.72454468
25MP0003436_decreased_susceptibility_to1.71841961
26MP0005451_abnormal_body_composition1.62536873
27MP0002148_abnormal_hypersensitivity_rea1.55614615
28MP0005025_abnormal_response_to1.55195464
29MP0005166_decreased_susceptibility_to1.54207920
30MP0009333_abnormal_splenocyte_physiolog1.53998498
31MP0004264_abnormal_extraembryonic_tissu1.53094185
32MP0002277_abnormal_respiratory_mucosa1.51566158
33MP0003075_altered_response_to1.50508731
34MP0002254_reproductive_system_inflammat1.47965747
35MP0008260_abnormal_autophagy1.46514671
36MP0001764_abnormal_homeostasis1.42584118
37MP0001853_heart_inflammation1.41034370
38MP0004957_abnormal_blastocyst_morpholog1.40884796
39MP0003300_gastrointestinal_ulcer1.39737903
40MP0003724_increased_susceptibility_to1.38469604
41MP0005165_increased_susceptibility_to1.37996537
42MP0010352_gastrointestinal_tract_polyps1.36789012
43MP0001790_abnormal_immune_system1.36583090
44MP0005387_immune_system_phenotype1.36583090
45MP0003763_abnormal_thymus_physiology1.34087024
46MP0005000_abnormal_immune_tolerance1.32984789
47MP0001845_abnormal_inflammatory_respons1.32090781
48MP0001800_abnormal_humoral_immune1.31862616
49MP0005671_abnormal_response_to1.31616246
50MP0002653_abnormal_ependyma_morphology1.30297857
51MP0003866_abnormal_defecation1.29217477
52MP0010234_abnormal_vibrissa_follicle1.27996644
53MP0008469_abnormal_protein_level1.27957639
54MP0005319_abnormal_enzyme/_coenzyme1.26933815
55MP0005636_abnormal_mineral_homeostasis1.25816952
56MP0002452_abnormal_antigen_presenting1.24982573
57MP0002419_abnormal_innate_immunity1.24933767
58MP0002405_respiratory_system_inflammati1.24172114
59MP0006054_spinal_hemorrhage1.23628773
60MP0010329_abnormal_lipoprotein_level1.20961166
61MP0003195_calcinosis1.20800027
62MP0002136_abnormal_kidney_physiology1.19411784
63MP0000609_abnormal_liver_physiology1.18652218
64MP0002132_abnormal_respiratory_system1.18542326
65MP0002723_abnormal_immune_serum1.18535317
66MP0006082_CNS_inflammation1.18478354
67MP0002166_altered_tumor_susceptibility1.15277370
68MP0004782_abnormal_surfactant_physiolog1.14819540
69MP0001663_abnormal_digestive_system1.14661987
70MP0001819_abnormal_immune_cell1.13544063
71MP0003878_abnormal_ear_physiology1.13132775
72MP0005377_hearing/vestibular/ear_phenot1.13132775
73MP0002420_abnormal_adaptive_immunity1.12670529
74MP0002933_joint_inflammation1.09960397
75MP0009764_decreased_sensitivity_to1.07935811
76MP0005464_abnormal_platelet_physiology1.07821954
77MP0000678_abnormal_parathyroid_gland1.07312381
78MP0004947_skin_inflammation1.06143909
79MP0005310_abnormal_salivary_gland1.05601946
80MP0003718_maternal_effect1.05010040
81MP0001765_abnormal_ion_homeostasis1.02611910
82MP0005164_abnormal_response_to1.01454982
83MP0004510_myositis1.00962385
84MP0000477_abnormal_intestine_morphology1.00899085
85MP0005058_abnormal_lysosome_morphology1.00548827
86MP0000858_altered_metastatic_potential1.00275350
87MP0005083_abnormal_biliary_tract0.99597993
88MP0003453_abnormal_keratinocyte_physiol0.96152352
89MP0001756_abnormal_urination0.96012791
90MP0000716_abnormal_immune_system0.95630902
91MP0000689_abnormal_spleen_morphology0.95425558
92MP0003172_abnormal_lysosome_physiology0.94053060
93MP0002006_tumorigenesis0.94046370
94MP0002396_abnormal_hematopoietic_system0.93493695
95MP0002398_abnormal_bone_marrow0.93182581
96MP0005084_abnormal_gallbladder_morpholo0.93108683
97MP0002722_abnormal_immune_system0.92992206
98MP0002429_abnormal_blood_cell0.90783415
99MP0002876_abnormal_thyroid_physiology0.90781723
100MP0005381_digestive/alimentary_phenotyp0.89919731
101MP0002998_abnormal_bone_remodeling0.86421350
102MP0005584_abnormal_enzyme/coenzyme_acti0.86345124
103MP0000598_abnormal_liver_morphology0.86308660
104MP0006036_abnormal_mitochondrial_physio0.85922127
105MP0004043_abnormal_pH_regulation0.83347008
106MP0003077_abnormal_cell_cycle0.82719339
107MP0009765_abnormal_xenobiotic_induced0.82289733
108MP0005397_hematopoietic_system_phenotyp0.81125717
109MP0001545_abnormal_hematopoietic_system0.81125717
110MP0009763_increased_sensitivity_to0.80604763
111MP0005390_skeleton_phenotype0.80267145
112MP0000703_abnormal_thymus_morphology0.79589768
113MP0002796_impaired_skin_barrier0.79068901
114MP0003656_abnormal_erythrocyte_physiolo0.78359559
115MP0001533_abnormal_skeleton_physiology0.78202279
116MP0003705_abnormal_hypodermis_morpholog0.77983157
117MP0005023_abnormal_wound_healing0.77752263
118MP0002019_abnormal_tumor_incidence0.77682648
119MP0003448_altered_tumor_morphology0.77366789
120MP0008004_abnormal_stomach_pH0.76765538
121MP0000343_altered_response_to0.76454102
122MP0008873_increased_physiological_sensi0.74277072

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.41761696
2Abnormal respiratory motile cilium physiology (HP:0012261)6.35673188
3Abnormal respiratory motile cilium morphology (HP:0005938)6.33308078
4Abnormal respiratory epithelium morphology (HP:0012253)6.33308078
5Absent/shortened dynein arms (HP:0200106)6.02755282
6Dynein arm defect of respiratory motile cilia (HP:0012255)6.02755282
7Abnormal ciliary motility (HP:0012262)5.95776963
8Rhinitis (HP:0012384)5.90130709
9Chronic bronchitis (HP:0004469)4.97878461
10Bronchiectasis (HP:0002110)4.79645530
11Abnormality of the nasal mucosa (HP:0000433)4.77241313
12Recurrent sinusitis (HP:0011108)3.54413495
13Bronchitis (HP:0012387)3.39926650
14Increased IgM level (HP:0003496)3.23205547
15Chronic sinusitis (HP:0011109)3.18147620
16Abnormality of glutamine family amino acid metabolism (HP:0010902)3.17248219
17Recurrent otitis media (HP:0000403)3.10887807
18Abnormality of monocarboxylic acid metabolism (HP:0010996)3.04244713
19Pustule (HP:0200039)3.00228489
20Abnormality of aromatic amino acid family metabolism (HP:0004338)2.97724435
21Generalized aminoaciduria (HP:0002909)2.86713721
22Vacuolated lymphocytes (HP:0001922)2.79815925
23Male infertility (HP:0003251)2.79749696
24Eczematoid dermatitis (HP:0000976)2.79728054
25Autoimmune thrombocytopenia (HP:0001973)2.77125297
26Intrahepatic cholestasis (HP:0001406)2.76061102
27Hyperglycinuria (HP:0003108)2.70588283
28Reticulocytopenia (HP:0001896)2.66550726
29Abnormality of fatty-acid metabolism (HP:0004359)2.63633544
30Glucose intolerance (HP:0000833)2.62846893
31Chronic otitis media (HP:0000389)2.58597333
32Abnormal delayed hypersensitivity skin test (HP:0002963)2.58549486
33Infertility (HP:0000789)2.55390056
34Abnormality of dicarboxylic acid metabolism (HP:0010995)2.53025166
35Dicarboxylic aciduria (HP:0003215)2.53025166
36Recurrent gram-negative bacterial infections (HP:0005420)2.51757035
37Nausea (HP:0002018)2.51561643
38Proximal tubulopathy (HP:0000114)2.49279094
39Hyperammonemia (HP:0001987)2.47057456
40Hypoglycemic coma (HP:0001325)2.42682253
41Ileus (HP:0002595)2.41237276
42Abnormality of cells of the erythroid lineage (HP:0012130)2.40453495
43Reduced antithrombin III activity (HP:0001976)2.38626224
44Myositis (HP:0100614)2.38482111
45Hepatic necrosis (HP:0002605)2.36502018
46Recurrent bacterial skin infections (HP:0005406)2.36272886
47Recurrent abscess formation (HP:0002722)2.35773004
48Abnormal number of erythroid precursors (HP:0012131)2.33187915
49Glycosuria (HP:0003076)2.33016478
50Abnormality of urine glucose concentration (HP:0011016)2.33016478
51Elevated erythrocyte sedimentation rate (HP:0003565)2.31570689
52Petechiae (HP:0000967)2.30105516
53Thrombocytosis (HP:0001894)2.28763922
54Hypobetalipoproteinemia (HP:0003563)2.28539883
55Obstructive lung disease (HP:0006536)2.28034673
56Chronic obstructive pulmonary disease (HP:0006510)2.28034673
57Abnormality of purine metabolism (HP:0004352)2.27682243
58Abnormality of nucleobase metabolism (HP:0010932)2.26817453
59Gout (HP:0001997)2.25176227
60Abnormality of pyrimidine metabolism (HP:0004353)2.25087873
61Multiple enchondromatosis (HP:0005701)2.24636247
62IgM deficiency (HP:0002850)2.21253067
63Abnormality of proline metabolism (HP:0010907)2.21081918
64Hydroxyprolinuria (HP:0003080)2.21081918
65Atelectasis (HP:0100750)2.20996788
66Lethargy (HP:0001254)2.20185174
67Abnormality of glycolipid metabolism (HP:0010969)2.20044168
68Abnormality of liposaccharide metabolism (HP:0010968)2.20044168
69Abnormality of glycosphingolipid metabolism (HP:0004343)2.20044168
70Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.19753937
71Abnormality of serine family amino acid metabolism (HP:0010894)2.17900505
72Abnormality of glycine metabolism (HP:0010895)2.17900505
73Stomatitis (HP:0010280)2.16231698
74Abnormal tarsal ossification (HP:0008369)2.11661827
75Fat malabsorption (HP:0002630)2.09961118
76Abnormality of aspartate family amino acid metabolism (HP:0010899)2.09915774
77Hypergammaglobulinemia (HP:0010702)2.09479656
78Increased serum ferritin (HP:0003281)2.08849116
79Decreased activity of mitochondrial respiratory chain (HP:0008972)2.08607491
80Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.08607491
81Abnormal hemoglobin (HP:0011902)2.06587217
82Combined immunodeficiency (HP:0005387)2.06191151
83Granulocytopenia (HP:0001913)2.05969874
84Malnutrition (HP:0004395)2.05701404
85Xanthomatosis (HP:0000991)2.05690932
86Trismus (HP:0000211)2.05676345
87Hyperactive renin-angiotensin system (HP:0000841)2.05271938
88Purpura (HP:0000979)2.04619491
89Recurrent fungal infections (HP:0002841)2.03932985
90Abnormality of macrophages (HP:0004311)2.03808932
91Abnormality of sulfur amino acid metabolism (HP:0004339)2.03596234
92Abnormality of T cell physiology (HP:0011840)2.03287971
93Aplasia/Hypoplasia of the sacrum (HP:0008517)2.01723275
94Macrocytic anemia (HP:0001972)1.98976389
95Lip pit (HP:0100267)1.98854284
96Oral leukoplakia (HP:0002745)1.97748643
97Vasculitis (HP:0002633)1.96582343
98Distal lower limb muscle weakness (HP:0009053)1.95684825
99Recurrent skin infections (HP:0001581)1.94808489
100Hyperglycinemia (HP:0002154)1.94667731
101Meningitis (HP:0001287)1.94363515
102Alkalosis (HP:0001948)1.93074608
103Systemic lupus erythematosus (HP:0002725)1.92347793
104Agammaglobulinemia (HP:0004432)1.91821546
105Dysostosis multiplex (HP:0000943)1.88278759
106Severe combined immunodeficiency (HP:0004430)1.87566434
107Cheilitis (HP:0100825)1.86210761
108Prolonged partial thromboplastin time (HP:0003645)1.85778308
109Hepatocellular necrosis (HP:0001404)1.85712744
110Hypertensive crisis (HP:0100735)1.85028402
111Abnormality of T cell number (HP:0011839)1.84853814
112Chronic diarrhea (HP:0002028)1.84012859
113Recurrent bronchitis (HP:0002837)1.83781409
114Vascular calcification (HP:0004934)1.83543127
115Hyperuricemia (HP:0002149)1.83435840
116Increased purine levels (HP:0004368)1.83435840
117Increased muscle lipid content (HP:0009058)1.81789931
118Abnormal glucose tolerance (HP:0001952)1.81680460
119Abnormality of chloride homeostasis (HP:0011422)1.81554495
120Chronic mucocutaneous candidiasis (HP:0002728)1.81232434
121Recurrent cutaneous fungal infections (HP:0011370)1.81232434
122Esophageal varix (HP:0002040)1.81125779
123Eosinophilia (HP:0001880)1.80187807
124Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.78348315
125Abnormal cartilage morphology (HP:0002763)1.76549917
126Hyperbilirubinemia (HP:0002904)1.76202620
127Mediastinal lymphadenopathy (HP:0100721)1.75184509
128Type I transferrin isoform profile (HP:0003642)1.75090756
129Hyperphosphaturia (HP:0003109)1.74652185
130Abnormality of the distal phalanges of the toes (HP:0010182)1.73974043
13111 pairs of ribs (HP:0000878)1.73789211
132Abnormality of T cells (HP:0002843)1.73779156
133Rough bone trabeculation (HP:0100670)1.72995056
134Urticaria (HP:0001025)1.72701778
135Aplastic anemia (HP:0001915)1.72439491
136Nasal polyposis (HP:0100582)1.71413811
137Autoimmune hemolytic anemia (HP:0001890)1.70904677
138Nonimmune hydrops fetalis (HP:0001790)1.70670974
139Metabolic acidosis (HP:0001942)1.69493043
140Pancreatitis (HP:0001733)1.69140284
141Abnormality of transition element cation homeostasis (HP:0011030)1.68128879
142Abnormality of iron homeostasis (HP:0011031)1.68071417
143Inflammation of the large intestine (HP:0002037)1.67878634
144Steatorrhea (HP:0002570)1.67566129
145Lipid accumulation in hepatocytes (HP:0006561)1.66965721
146Joint hemorrhage (HP:0005261)1.66899978
147Interstitial pulmonary disease (HP:0006530)1.66858467
148Orchitis (HP:0100796)1.66451697
149Gastrointestinal stroma tumor (HP:0100723)1.64082267
150Axonal loss (HP:0003447)1.62197665
151Skin rash (HP:0000988)1.61417006
152Loss of speech (HP:0002371)1.60440342
153Pulmonary infiltrates (HP:0002113)1.57633490
154Hepatosplenomegaly (HP:0001433)1.57079680
155Seborrheic dermatitis (HP:0001051)1.56536719
156Vertebral compression fractures (HP:0002953)1.55745388
157Abnormality of polysaccharide metabolism (HP:0011012)1.53319248
158Abnormality of glycosaminoglycan metabolism (HP:0004371)1.53319248
159Abnormality of mucopolysaccharide metabolism (HP:0011020)1.53319248
160Recurrent viral infections (HP:0004429)1.51904333
161Renal salt wasting (HP:0000127)1.51494403
162Amyloidosis (HP:0011034)1.51391237
163Hypochromic anemia (HP:0001931)1.49548608
164Gastrointestinal infarctions (HP:0005244)1.49408558
165Urinary glycosaminoglycan excretion (HP:0003541)1.48944872
166Mucopolysacchariduria (HP:0008155)1.48944872
167Increased intramyocellular lipid droplets (HP:0012240)1.47829915
168Severe visual impairment (HP:0001141)1.47282911
169Joint swelling (HP:0001386)1.44176380
170Abnormality of small intestinal villus morphology (HP:0011472)1.44168796
171Villous atrophy (HP:0011473)1.44168796

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.05423750
2ERN12.75357952
3MST42.59173206
4EIF2AK12.41928867
5BCKDK2.29400066
6TESK12.25611221
7MAP4K12.24923899
8BUB12.23878699
9IRAK32.23693463
10PBK1.99440110
11MAP3K141.93073610
12KDR1.92066804
13MAP2K21.91376237
14RIPK41.90684675
15EPHA21.90022362
16PIM21.86337065
17BLK1.80975785
18TESK21.77904945
19MAP3K31.71889393
20TBK11.69424790
21SMG11.68717535
22MAP3K121.67786970
23VRK21.51613592
24NUAK11.51586984
25MST1R1.49032097
26TAOK21.48955820
27EIF2AK31.47902654
28TYK21.46098310
29TEC1.42551794
30IRAK41.39805114
31MAP3K111.36780709
32STK101.36592879
33WEE11.34863055
34STK241.32845128
35RPS6KA41.29307880
36IKBKE1.29267304
37ARAF1.28919311
38NLK1.28608124
39RPS6KB21.25328337
40ZAP701.24740830
41TTK1.21551585
42NEK21.20259173
43TRIB31.19578662
44STK38L1.19540239
45LRRK21.18832883
46DYRK31.17416900
47STK161.16803309
48EPHB11.12861985
49BMPR21.12128081
50IKBKB1.09916989
51BTK1.06756703
52MAP2K31.06554429
53PAK41.05811401
54NME11.05789783
55GRK61.04921909
56MAP3K101.04805878
57PRPF4B1.02662607
58PLK41.02100498
59FRK0.97298073
60PRKG20.96311540
61PIM10.95252991
62AURKB0.93699689
63BRSK20.92567478
64MAP3K80.90804633
65TAOK10.88239321
66MAP3K10.86987722
67VRK10.86536944
68MAP2K60.86485834
69LIMK10.85655974
70ABL20.85654387
71PDK20.85212836
72TLK10.84670792
73TXK0.82882280
74FGFR40.81100795
75RIPK10.80946412
76PIK3CG0.80682539
77STK40.79160696
78JAK30.78658956
79TAOK30.75057219
80MAP3K130.74715590
81MAPKAPK30.74660011
82CDK190.74247439
83ZAK0.73410707
84CSK0.72659657
85MAP3K20.72344646
86SCYL20.70392086
87WNK40.69940632
88CHUK0.69932894
89SIK30.67400782
90LCK0.67178043
91PRKCI0.65153398
92LMTK20.64633868
93PASK0.64297803
94PTK20.63645860
95PLK10.63323886
96TNK20.62113605
97PDPK10.61993100
98DYRK1B0.61465036
99PRKCQ0.61131972
100PDK30.60199344
101PDK40.60199344
102CLK10.59772474
103SIK10.58973942
104CDK40.58509711
105LYN0.57374106
106MYLK0.56920635
107CDK70.56636219
108PTK60.55764696
109MAPK150.55684741
110TGFBR20.54448438
111PIK3CA0.54436691
112JAK10.51927089
113ITK0.51583800
114FES0.50895891
115DAPK10.50361417
116KIT0.49881460
117HIPK20.49656620
118NEK90.49464249
119SYK0.48904645
120MAPK110.48352967
121GRK70.47979419
122PAK10.45035843
123PDK10.45022228
124ACVR1B0.44626405
125MOS0.41496607
126HCK0.41071771
127MAPKAPK20.40610873
128MATK0.40102464
129PRKCD0.39907377
130CSNK2A10.39724812
131GRK10.39109314
132ILK0.37223157
133MAPK120.36317640
134FLT30.36137309
135CSF1R0.36108976
136MARK30.36016709
137MAP3K50.30682613
138PTK2B0.30272118

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.11295016
2Autoimmune thyroid disease_Homo sapiens_hsa053202.92560727
3Graft-versus-host disease_Homo sapiens_hsa053322.78232945
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.64661044
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.46501074
6Ribosome_Homo sapiens_hsa030102.44833101
7Type I diabetes mellitus_Homo sapiens_hsa049402.24466023
8Proteasome_Homo sapiens_hsa030502.23841032
9Sulfur metabolism_Homo sapiens_hsa009202.17726768
10Asthma_Homo sapiens_hsa053102.07252787
11Folate biosynthesis_Homo sapiens_hsa007902.00652911
12DNA replication_Homo sapiens_hsa030301.96539344
13Sulfur relay system_Homo sapiens_hsa041221.83568971
14Glutathione metabolism_Homo sapiens_hsa004801.81504463
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.78776625
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.70967622
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.67624221
18Drug metabolism - other enzymes_Homo sapiens_hsa009831.66072451
19Chemical carcinogenesis_Homo sapiens_hsa052041.61374767
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.60299108
21Histidine metabolism_Homo sapiens_hsa003401.53229017
22Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.52428523
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.50034096
24Pentose phosphate pathway_Homo sapiens_hsa000301.47128842
25Mismatch repair_Homo sapiens_hsa034301.46600681
26Rheumatoid arthritis_Homo sapiens_hsa053231.45952539
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.44573579
28Fatty acid degradation_Homo sapiens_hsa000711.42541301
29Caffeine metabolism_Homo sapiens_hsa002321.40989330
30Peroxisome_Homo sapiens_hsa041461.37614351
31Selenocompound metabolism_Homo sapiens_hsa004501.37527936
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.37281416
33Tryptophan metabolism_Homo sapiens_hsa003801.36306348
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36212450
35Pyrimidine metabolism_Homo sapiens_hsa002401.34823533
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.34651910
37Homologous recombination_Homo sapiens_hsa034401.32807733
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32147614
39One carbon pool by folate_Homo sapiens_hsa006701.31735390
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.26424633
41Fat digestion and absorption_Homo sapiens_hsa049751.23678241
42Viral myocarditis_Homo sapiens_hsa054161.21557427
43Base excision repair_Homo sapiens_hsa034101.21274814
44Influenza A_Homo sapiens_hsa051641.21123248
45Protein export_Homo sapiens_hsa030601.16678328
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.16045256
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.14200660
48Lysosome_Homo sapiens_hsa041421.12758892
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.12749594
50Intestinal immune network for IgA production_Homo sapiens_hsa046721.11540894
51RNA polymerase_Homo sapiens_hsa030201.08891464
52Primary immunodeficiency_Homo sapiens_hsa053401.08395422
53Vitamin digestion and absorption_Homo sapiens_hsa049771.08022411
54Measles_Homo sapiens_hsa051621.07213381
55SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07163011
56Osteoclast differentiation_Homo sapiens_hsa043801.06411013
57Other glycan degradation_Homo sapiens_hsa005111.06273363
58Steroid hormone biosynthesis_Homo sapiens_hsa001401.06027349
59African trypanosomiasis_Homo sapiens_hsa051431.03092859
60Carbon metabolism_Homo sapiens_hsa012001.01534686
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01064996
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.99723152
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.99612342
64Fructose and mannose metabolism_Homo sapiens_hsa000510.99294122
65Pyruvate metabolism_Homo sapiens_hsa006200.98403877
66Antigen processing and presentation_Homo sapiens_hsa046120.98026508
67Arginine biosynthesis_Homo sapiens_hsa002200.97438432
68Propanoate metabolism_Homo sapiens_hsa006400.96931579
69Retinol metabolism_Homo sapiens_hsa008300.95909247
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.94781519
71beta-Alanine metabolism_Homo sapiens_hsa004100.93765725
72Galactose metabolism_Homo sapiens_hsa000520.93564864
73Staphylococcus aureus infection_Homo sapiens_hsa051500.93216676
74Complement and coagulation cascades_Homo sapiens_hsa046100.92682091
75Arginine and proline metabolism_Homo sapiens_hsa003300.91278752
76Toxoplasmosis_Homo sapiens_hsa051450.91073999
77Tuberculosis_Homo sapiens_hsa051520.90837928
78Oxidative phosphorylation_Homo sapiens_hsa001900.90566683
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90464356
80Starch and sucrose metabolism_Homo sapiens_hsa005000.90158553
81Arachidonic acid metabolism_Homo sapiens_hsa005900.88959956
82Hepatitis C_Homo sapiens_hsa051600.87295523
83TNF signaling pathway_Homo sapiens_hsa046680.86918673
84PPAR signaling pathway_Homo sapiens_hsa033200.84856161
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.84327295
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83588643
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81959350
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81930797
89Salmonella infection_Homo sapiens_hsa051320.81445074
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.80784059
91Linoleic acid metabolism_Homo sapiens_hsa005910.80288526
92Malaria_Homo sapiens_hsa051440.79623744
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79175084
94Legionellosis_Homo sapiens_hsa051340.79067354
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78804019
96Pertussis_Homo sapiens_hsa051330.78763863
97Leishmaniasis_Homo sapiens_hsa051400.77196568
98Biosynthesis of amino acids_Homo sapiens_hsa012300.76962855
99Nucleotide excision repair_Homo sapiens_hsa034200.75802762
100Butanoate metabolism_Homo sapiens_hsa006500.75348313
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.75209153
102Apoptosis_Homo sapiens_hsa042100.74250053
103T cell receptor signaling pathway_Homo sapiens_hsa046600.73072469
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.71999155
105Parkinsons disease_Homo sapiens_hsa050120.71987733
106Shigellosis_Homo sapiens_hsa051310.70809634
107B cell receptor signaling pathway_Homo sapiens_hsa046620.70111922
108Metabolic pathways_Homo sapiens_hsa011000.68724956
109Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68260546
110RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66343401
1112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64587609
112Sphingolipid metabolism_Homo sapiens_hsa006000.64062967
113Mineral absorption_Homo sapiens_hsa049780.63240944
114Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62767390
115Phagosome_Homo sapiens_hsa041450.59732966
116Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59606739
117Non-homologous end-joining_Homo sapiens_hsa034500.59507447
118p53 signaling pathway_Homo sapiens_hsa041150.56171337
119Phenylalanine metabolism_Homo sapiens_hsa003600.55500548
120Spliceosome_Homo sapiens_hsa030400.55206738
121Huntingtons disease_Homo sapiens_hsa050160.55120848
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55061395
123Nitrogen metabolism_Homo sapiens_hsa009100.54762316
124Vitamin B6 metabolism_Homo sapiens_hsa007500.53973163
125ABC transporters_Homo sapiens_hsa020100.53803874
126Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53233567
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52046358
128Fatty acid metabolism_Homo sapiens_hsa012120.52013414
129Acute myeloid leukemia_Homo sapiens_hsa052210.51771062
130Purine metabolism_Homo sapiens_hsa002300.51365745
131Glycerolipid metabolism_Homo sapiens_hsa005610.50908158
132RNA transport_Homo sapiens_hsa030130.50528514
133Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49931286
134Hematopoietic cell lineage_Homo sapiens_hsa046400.49878501
135Collecting duct acid secretion_Homo sapiens_hsa049660.49622537
136Vibrio cholerae infection_Homo sapiens_hsa051100.49340872
137Herpes simplex infection_Homo sapiens_hsa051680.48717209
138Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47877091
139Tyrosine metabolism_Homo sapiens_hsa003500.47651165
140Epstein-Barr virus infection_Homo sapiens_hsa051690.47267435
141Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46766214
142Renin-angiotensin system_Homo sapiens_hsa046140.46734519
143Bile secretion_Homo sapiens_hsa049760.46650859
144Jak-STAT signaling pathway_Homo sapiens_hsa046300.41869302

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