CIB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product shares a high degree of sequence similarity with DNA-dependent protein kinase catalytic subunit-interacting protein 2 in human and mouse, and like them may bind the catalytic subunit of DNA-dependent protein kinases. The exact function of this gene is not known. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endocrine pancreas development (GO:0031018)6.38744571
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.28236414
3L-phenylalanine catabolic process (GO:0006559)6.28236414
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.89093121
5L-phenylalanine metabolic process (GO:0006558)5.89093121
6neutrophil activation involved in immune response (GO:0002283)5.51814840
7positive regulation by symbiont of host defense response (GO:0052509)5.39831261
8modulation by symbiont of host defense response (GO:0052031)5.39831261
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.39831261
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.39831261
11positive regulation by organism of defense response of other organism involved in symbiotic interact5.39831261
12modulation by symbiont of host immune response (GO:0052553)5.39831261
13regulation of interferon-beta biosynthetic process (GO:0045357)5.11459604
14regulation of platelet aggregation (GO:0090330)5.02648353
15aromatic amino acid family catabolic process (GO:0009074)4.92049766
16thrombin receptor signaling pathway (GO:0070493)4.88157636
17response to peptidoglycan (GO:0032494)4.86151113
18signal peptide processing (GO:0006465)4.79693911
19positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.70019435
20definitive hemopoiesis (GO:0060216)4.63482868
21negative regulation of erythrocyte differentiation (GO:0045647)4.50122733
22platelet aggregation (GO:0070527)4.45235977
23tyrosine metabolic process (GO:0006570)4.43318150
24positive regulation of gamma-delta T cell activation (GO:0046645)4.40294107
25regulation of histone phosphorylation (GO:0033127)4.39122777
26cellular response to leptin stimulus (GO:0044320)4.36193710
27COPI coating of Golgi vesicle (GO:0048205)4.33093698
28Golgi transport vesicle coating (GO:0048200)4.33093698
29maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.30158801
30positive regulation of B cell differentiation (GO:0045579)4.30095794
31response to host immune response (GO:0052572)4.30074254
32response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.30074254
33lipoxygenase pathway (GO:0019372)4.26999112
34protein retention in ER lumen (GO:0006621)4.24508181
35pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.23933630
36regulation of mast cell degranulation (GO:0043304)4.17242219
37neutrophil activation (GO:0042119)4.16528194
38purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.14553831
393-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.14553831
40regulation of type B pancreatic cell apoptotic process (GO:2000674)4.08865759
41positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.06359179
42glandular epithelial cell differentiation (GO:0002067)4.04914226
43peptide hormone processing (GO:0016486)3.99812295
44defense response to protozoan (GO:0042832)3.95867319
45protein maturation by protein folding (GO:0022417)3.94854773
46superoxide anion generation (GO:0042554)3.94512678
47response to protozoan (GO:0001562)3.93482621
48blood coagulation, intrinsic pathway (GO:0007597)3.93061228
49macrophage activation involved in immune response (GO:0002281)3.92628492
50regulation of fibrinolysis (GO:0051917)3.92532472
51regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.92270476
52urea cycle (GO:0000050)3.91365913
53urea metabolic process (GO:0019627)3.91365913
54tryptophan metabolic process (GO:0006568)3.85249763
55pentose-phosphate shunt (GO:0006098)3.84424364
56response to leptin (GO:0044321)3.81788927
57response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.78264084
58response to host (GO:0075136)3.78264084
59response to host defenses (GO:0052200)3.78264084
60pyrimidine nucleotide catabolic process (GO:0006244)3.73102186
61regulation of mast cell activation involved in immune response (GO:0033006)3.72906449
62regulation of myeloid leukocyte mediated immunity (GO:0002886)3.72661323
63response to pheromone (GO:0019236)3.72650775
64regulation of hexokinase activity (GO:1903299)3.72606743
65regulation of glucokinase activity (GO:0033131)3.72606743
66pentose metabolic process (GO:0019321)3.70372266
67aromatic amino acid family metabolic process (GO:0009072)3.66071281
68G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.64482945
69sequestering of metal ion (GO:0051238)3.64105383
70regulation of leukocyte degranulation (GO:0043300)3.62893170
71base-excision repair, AP site formation (GO:0006285)3.62788529
72complement activation, alternative pathway (GO:0006957)3.61252488
73indole-containing compound catabolic process (GO:0042436)3.61234522
74indolalkylamine catabolic process (GO:0046218)3.61234522
75tryptophan catabolic process (GO:0006569)3.61234522
76nitrogen cycle metabolic process (GO:0071941)3.60780271
77triglyceride homeostasis (GO:0070328)3.59962581
78acylglycerol homeostasis (GO:0055090)3.59962581
79granulocyte activation (GO:0036230)3.59773020
80positive regulation of insulin secretion (GO:0032024)3.59354425
81regulation of B cell differentiation (GO:0045577)3.58609988
82detection of molecule of bacterial origin (GO:0032490)3.56745650
83regulation of platelet activation (GO:0010543)3.53797062
84germinal center formation (GO:0002467)3.52932411
85long term synaptic depression (GO:0060292)3.50193500
86sulfur amino acid catabolic process (GO:0000098)3.47945009
87COPII vesicle coating (GO:0048208)3.45316453
88regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.43765688
89homotypic cell-cell adhesion (GO:0034109)3.41709135
90type B pancreatic cell development (GO:0003323)3.41341985
91NADPH regeneration (GO:0006740)3.40127734
92negative regulation of interleukin-6 production (GO:0032715)3.39751871
93regulation of B cell receptor signaling pathway (GO:0050855)3.37153749
94megakaryocyte development (GO:0035855)3.34940436
95cysteine metabolic process (GO:0006534)3.34832427
96neutrophil mediated immunity (GO:0002446)3.34292357
97peptidyl-glutamic acid carboxylation (GO:0017187)3.33414950
98protein carboxylation (GO:0018214)3.33414950
99positive regulation of glycolytic process (GO:0045821)3.32322202
100glandular epithelial cell development (GO:0002068)3.31956720
101regulation of mitochondrial depolarization (GO:0051900)3.31002079
102regulation of gamma-delta T cell differentiation (GO:0045586)3.30803697
103kynurenine metabolic process (GO:0070189)3.30765687
104negative regulation of fibrinolysis (GO:0051918)3.29329668
105triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.28825380
106regulation of integrin activation (GO:0033623)3.28662286
107regulation of inositol phosphate biosynthetic process (GO:0010919)3.28288280
108high-density lipoprotein particle remodeling (GO:0034375)3.27539362
109glyoxylate metabolic process (GO:0046487)3.27460463
110regulation of gamma-delta T cell activation (GO:0046643)3.24953083
111positive regulation of Cdc42 GTPase activity (GO:0043089)3.23040539
112ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.21690104
113macrophage activation (GO:0042116)3.21338289
114negative regulation of homotypic cell-cell adhesion (GO:0034111)3.21064897
115antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.20655478
116bile acid metabolic process (GO:0008206)3.19822232
117detection of light stimulus involved in sensory perception (GO:0050962)3.19609797
118detection of light stimulus involved in visual perception (GO:0050908)3.19609797
119cellular extravasation (GO:0045123)3.19578471
120indolalkylamine metabolic process (GO:0006586)3.19519239
121epithelial cell fate commitment (GO:0072148)3.18297007
122tricarboxylic acid metabolic process (GO:0072350)3.17690768
123negative regulation of phagocytosis (GO:0050765)3.17578936
124nucleoside diphosphate catabolic process (GO:0009134)3.17340036
125drug transmembrane transport (GO:0006855)3.16442683
126B cell receptor signaling pathway (GO:0050853)3.14569439
127positive regulation of peptide hormone secretion (GO:0090277)3.14447494
128regulation of protein activation cascade (GO:2000257)3.13979084
129negative regulation of innate immune response (GO:0045824)3.13755237
130insulin secretion (GO:0030073)3.13555489
131myeloid cell activation involved in immune response (GO:0002275)3.13201533
132bile acid biosynthetic process (GO:0006699)3.12364665
133regulation of regulated secretory pathway (GO:1903305)3.09527771
134regulation of insulin secretion (GO:0050796)3.09522450
135valine metabolic process (GO:0006573)3.08867048
136regulation of erythrocyte differentiation (GO:0045646)3.08733044
137aldehyde catabolic process (GO:0046185)3.07920570
138bile acid and bile salt transport (GO:0015721)3.07698293
139negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.07408891
140pyrimidine nucleoside catabolic process (GO:0046135)3.07008292
141positive regulation of endothelial cell differentiation (GO:0045603)3.07001123
142purinergic nucleotide receptor signaling pathway (GO:0035590)3.04637976
143respiratory burst (GO:0045730)3.04588551
144negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.04407390
145negative regulation of cell killing (GO:0031342)3.04407390
146regulation of mast cell activation (GO:0033003)3.03880692
147reverse cholesterol transport (GO:0043691)3.02744786
148positive regulation of peptide secretion (GO:0002793)3.02119562
149ribonucleoside bisphosphate metabolic process (GO:0033875)3.01260353
150nucleoside bisphosphate metabolic process (GO:0033865)3.01260353
151purine nucleoside bisphosphate metabolic process (GO:0034032)3.01260353
152regulation of bile acid biosynthetic process (GO:0070857)3.00139771
153toxin metabolic process (GO:0009404)2.99441472
154leukocyte migration involved in inflammatory response (GO:0002523)2.95302592
155leukocyte degranulation (GO:0043299)2.95293113
156lipopolysaccharide-mediated signaling pathway (GO:0031663)2.94194699
157hepatocyte apoptotic process (GO:0097284)2.94190639
158acute-phase response (GO:0006953)2.93775941
159alkaloid metabolic process (GO:0009820)2.93727867
160deoxyribose phosphate catabolic process (GO:0046386)2.93520051
161negative regulation of lymphocyte mediated immunity (GO:0002707)2.92560263
162glucosamine-containing compound catabolic process (GO:1901072)2.90481266
163regulation of peptide hormone secretion (GO:0090276)2.90446322
164regulation of complement activation (GO:0030449)2.89797046
165cholesterol catabolic process (GO:0006707)2.89322981
166sterol catabolic process (GO:0016127)2.89322981
167leukocyte aggregation (GO:0070486)2.88975091
168negative regulation of bone resorption (GO:0045779)2.88595591
169regulation of peptide secretion (GO:0002791)2.85089695
170negative regulation of T cell mediated immunity (GO:0002710)2.84705501
171retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.83396435
172cholesterol efflux (GO:0033344)2.83302312
173protein activation cascade (GO:0072376)2.83045311
174microglial cell activation (GO:0001774)2.83017879
175regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.82854468
176presynaptic membrane assembly (GO:0097105)2.82565592
177protein autoprocessing (GO:0016540)2.81338338
178positive regulation of interferon-alpha production (GO:0032727)2.81158508
179glucose catabolic process (GO:0006007)2.81087780
180alpha-amino acid catabolic process (GO:1901606)2.80368218
181fibrinolysis (GO:0042730)2.80302719
182deoxyribonucleotide catabolic process (GO:0009264)2.79940511
183poly(A)+ mRNA export from nucleus (GO:0016973)2.79826605
184plasma lipoprotein particle remodeling (GO:0034369)2.79763936
185protein-lipid complex remodeling (GO:0034368)2.79763936
186macromolecular complex remodeling (GO:0034367)2.79763936
187regulation of oxidative phosphorylation (GO:0002082)2.79221279
188response to methylmercury (GO:0051597)2.78903382
189negative regulation of lipid catabolic process (GO:0050995)2.78259081
190regulation of cholesterol esterification (GO:0010872)2.78195266
191positive regulation of regulated secretory pathway (GO:1903307)2.77861989
192negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.77470788
193negative regulation of interleukin-12 production (GO:0032695)2.76551120
194phospholipid efflux (GO:0033700)2.74831382
195negative regulation of granulocyte differentiation (GO:0030853)2.74731063
196positive regulation of mast cell activation (GO:0033005)2.74184226
197amyloid precursor protein catabolic process (GO:0042987)2.72718070
198positive regulation of mast cell activation involved in immune response (GO:0033008)2.67602012
199positive regulation of mast cell degranulation (GO:0043306)2.67602012
200positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.67369876

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.57079528
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.02642534
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.93330461
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.65333775
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.58441021
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.53776481
7DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.82667704
8VDR_21846776_ChIP-Seq_THP-1_Human3.68739504
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.66554594
10GATA1_22025678_ChIP-Seq_K562_Human3.64416507
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.56016280
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.51988297
13SCL_19346495_ChIP-Seq_HPC-7_Human3.38275561
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.24586621
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.95153900
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.83416672
17VDR_24763502_ChIP-Seq_THP-1_Human2.76166585
18MYC_22102868_ChIP-Seq_BL_Human2.57886953
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.46642246
20SPI1_23547873_ChIP-Seq_NB4_Human2.45109180
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.37161544
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.34588130
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.29061686
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.23548988
25MAF_26560356_Chip-Seq_TH1_Human2.21561894
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.20820450
27* RUNX1_22412390_ChIP-Seq_EML_Mouse2.15945435
28EGR1_19374776_ChIP-ChIP_THP-1_Human2.13457181
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.11684245
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.07918790
31TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.03327891
32MYB_21317192_ChIP-Seq_ERMYB_Mouse2.01858639
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.01751650
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.01137926
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.99331473
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.96867048
37TCF7_22412390_ChIP-Seq_EML_Mouse1.96741061
38UTX_26944678_Chip-Seq_JUKART_Human1.91784831
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.91561144
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.91143218
41GATA1_22383799_ChIP-Seq_G1ME_Mouse1.85851260
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.82246635
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.81253741
44SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79138936
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72686375
46GATA2_22383799_ChIP-Seq_G1ME_Mouse1.72150460
47GATA1_19941827_ChIP-Seq_MEL_Mouse1.70980499
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70606286
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.70413388
50NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68276321
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.66873997
52MAF_26560356_Chip-Seq_TH2_Human1.65716819
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65696008
54TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.65556281
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63419416
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.59351845
57BRD4_27068464_Chip-Seq_AML-cells_Mouse1.57662243
58LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.54082506
59HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.53028372
60SPI1_23127762_ChIP-Seq_K562_Human1.51500912
61PU.1_20513432_ChIP-Seq_Bcells_Mouse1.48633355
62KDM2B_26808549_Chip-Seq_DND41_Human1.48409975
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.47666283
64MYB_26560356_Chip-Seq_TH2_Human1.47265976
65RACK7_27058665_Chip-Seq_MCF-7_Human1.46508516
66CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.46402658
67ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.46250776
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45210837
69IRF8_27001747_Chip-Seq_BMDM_Mouse1.43733429
70MYB_26560356_Chip-Seq_TH1_Human1.42938729
71ESR1_21235772_ChIP-Seq_MCF-7_Human1.40860243
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40567397
73SOX2_27498859_Chip-Seq_STOMACH_Mouse1.40349557
74FOXA2_19822575_ChIP-Seq_HepG2_Human1.40231133
75MYC_18358816_ChIP-ChIP_MESCs_Mouse1.39648829
76IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.37605159
77NCOR1_26117541_ChIP-Seq_K562_Human1.36603079
78KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36234554
79ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35485224
80BCL6_27268052_Chip-Seq_Bcells_Human1.35480130
81PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.35051582
82PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.32905684
83BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.31273243
84CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31001524
85FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30036318
86MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29561882
87JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.29346137
88NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.28812272
89PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26335152
90SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25852778
91CTCF_21964334_Chip-Seq_Bcells_Human1.23623195
92GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23567319
93BCOR_27268052_Chip-Seq_Bcells_Human1.23014345
94P68_20966046_ChIP-Seq_HELA_Human1.22350013
95* CTCF_26484167_Chip-Seq_Bcells_Mouse1.20650718
96EZH2_22144423_ChIP-Seq_EOC_Human1.20598087
97FOXP3_21729870_ChIP-Seq_TREG_Human1.20544375
98RUNX_20019798_ChIP-Seq_JUKART_Human1.20486864
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20117662
100ELF1_20517297_ChIP-Seq_JURKAT_Human1.19562215
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.18528722
102FOXA1_25552417_ChIP-Seq_VCAP_Human1.18440444
103YY1_21170310_ChIP-Seq_MESCs_Mouse1.16991618
104CIITA_25753668_ChIP-Seq_RAJI_Human1.16971998
105DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16011673
106ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15451738
107TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15299926
108STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.13950228
109THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13420753
110CTCF_21964334_ChIP-Seq_BJAB-B_Human1.13338388
111YY1_22570637_ChIP-Seq_MALME-3M_Human1.12888420
112HNF4A_19822575_ChIP-Seq_HepG2_Human1.12677555
113GABP_19822575_ChIP-Seq_HepG2_Human1.12454953
114GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12324596
115FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12123568
116GATA2_21666600_ChIP-Seq_HMVEC_Human1.11946598
117NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11727696
118FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.11611717
119KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11142285
120STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10982882
121* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.10897664
122RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08525655
123PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08190199
124ESR2_21235772_ChIP-Seq_MCF-7_Human1.08159436
125THAP11_20581084_ChIP-Seq_MESCs_Mouse1.07984996
126E2F1_20622854_ChIP-Seq_HELA_Human1.05230913
127CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04841863
128CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04610609
129ETS1_20019798_ChIP-Seq_JURKAT_Human1.04222770
130GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04058196
131SPI1_20517297_ChIP-Seq_HL60_Human1.03888190
132AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.02833553
133BCAT_22108803_ChIP-Seq_LS180_Human1.01240112
134ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00677523
135SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.00109944
136SOX2_20726797_ChIP-Seq_SW620_Human1.00039594
137EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99059773
138RUNX1_26923725_Chip-Seq_HPCs_Mouse0.98851504
139FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98576765
140REST_19997604_ChIP-ChIP_NEURONS_Mouse0.96828670
141SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96226772
142ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95814965
143GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.95463813
144GATA4_25053715_ChIP-Seq_YYC3_Human0.94148755
145NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94070811
146ERG_20517297_ChIP-Seq_VCAP_Human0.92241565
147IRF8_22096565_ChIP-ChIP_GC-B_Human0.90612286
148OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86476444
149SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82356436
150* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.81576434
151CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.78794941
152* GATA3_24758297_ChIP-Seq_MCF-7_Human0.77293930
153AR_20517297_ChIP-Seq_VCAP_Human0.76653027
154TBX20_22080862_ChIP-Seq_HEART_Mouse0.75403338
155TBX20_22328084_ChIP-Seq_HEART_Mouse0.75403338
156MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.75036990
157NFIB_24661679_ChIP-Seq_LUNG_Mouse0.73583023
158MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.73311145
159REST_21632747_ChIP-Seq_MESCs_Mouse0.72435593
160SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.72315943
161FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.69773158
162KLF4_19829295_ChIP-Seq_ESCs_Human0.67651566
163TET1_21451524_ChIP-Seq_MESCs_Mouse0.67319342
164NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.67055783
165* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.66748702
166SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.65654375
167GATA1_19941826_ChIP-Seq_K562_Human0.64859410
168GATA3_21878914_ChIP-Seq_MCF-7_Human0.64135640
169RXRA_24833708_ChIP-Seq_LIVER_Mouse0.63455215
170HTT_18923047_ChIP-ChIP_STHdh_Human0.63423269
171TCF4_22108803_ChIP-Seq_LS180_Human0.63070188
172BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.63069605
173HOXB7_26014856_ChIP-Seq_BT474_Human0.62739231
174CLOCK_20551151_ChIP-Seq_293T_Human0.61446249
175EGR1_19032775_ChIP-ChIP_M12_Human0.61362937
176FOXA1_27270436_Chip-Seq_PROSTATE_Human0.60936543
177FOXA1_25329375_ChIP-Seq_VCAP_Human0.60936543
178ZFX_18555785_Chip-Seq_ESCs_Mouse0.60319004
179CTBP2_25329375_ChIP-Seq_LNCAP_Human0.60042484
180SOX2_18555785_Chip-Seq_ESCs_Mouse0.59848945
181ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.59589582
182ETV2_25802403_ChIP-Seq_MESCs_Mouse0.59443549
183LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.59389970
184ESRRB_18555785_Chip-Seq_ESCs_Mouse0.58272586
185NRF2_20460467_ChIP-Seq_MEFs_Mouse0.58025039
186NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.58025039
187NMYC_18555785_Chip-Seq_ESCs_Mouse0.58016864
188RARB_24833708_ChIP-Seq_LIVER_Mouse0.57922679
189SPI1_26923725_Chip-Seq_HPCs_Mouse0.57658946
190LXR_22292898_ChIP-Seq_THP-1_Human0.57506568
191STAT1_20625510_ChIP-Seq_HELA_Human0.57404324
192PIAS1_25552417_ChIP-Seq_VCAP_Human0.57242035

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000465_gastrointestinal_hemorrhage7.12365089
2MP0002139_abnormal_hepatobiliary_system5.29776689
3MP0005464_abnormal_platelet_physiology4.68412111
4MP0005085_abnormal_gallbladder_physiolo4.49773730
5MP0005365_abnormal_bile_salt4.10988157
6MP0010386_abnormal_urinary_bladder4.08494583
7MP0000013_abnormal_adipose_tissue3.84456237
8MP0002837_dystrophic_cardiac_calcinosis3.74640588
9MP0003195_calcinosis3.69689189
10MP0003724_increased_susceptibility_to3.60135463
11MP0002877_abnormal_melanocyte_morpholog3.41213667
12MP0005360_urolithiasis3.36529480
13MP0004043_abnormal_pH_regulation3.30931718
14MP0002138_abnormal_hepatobiliary_system3.29148495
15MP0009780_abnormal_chondrocyte_physiolo3.28045897
16MP0003436_decreased_susceptibility_to3.17241186
17MP0002396_abnormal_hematopoietic_system3.03364533
18MP0002693_abnormal_pancreas_physiology3.00613791
19MP0008875_abnormal_xenobiotic_pharmacok2.99405423
20MP0003868_abnormal_feces_composition2.94505546
21MP0003252_abnormal_bile_duct2.91336543
22MP0003303_peritoneal_inflammation2.80877153
23MP0001944_abnormal_pancreas_morphology2.72308350
24MP0002132_abnormal_respiratory_system2.56831055
25MP0004808_abnormal_hematopoietic_stem2.56202129
26MP0002876_abnormal_thyroid_physiology2.51865616
27MP0003806_abnormal_nucleotide_metabolis2.39704905
28MP0008260_abnormal_autophagy2.36460878
29MP0002419_abnormal_innate_immunity2.35134000
30MP0005220_abnormal_exocrine_pancreas2.25206136
31MP0004185_abnormal_adipocyte_glucose2.23904731
32MP0005397_hematopoietic_system_phenotyp2.23040332
33MP0001545_abnormal_hematopoietic_system2.23040332
34MP0001348_abnormal_lacrimal_gland2.20655030
35MP0005025_abnormal_response_to2.16836720
36MP0006072_abnormal_retinal_apoptosis2.15995097
37MP0001835_abnormal_antigen_presentation2.11337799
38MP0003172_abnormal_lysosome_physiology2.11317857
39MP0010329_abnormal_lipoprotein_level2.09037782
40MP0005379_endocrine/exocrine_gland_phen2.08928134
41MP0002909_abnormal_adrenal_gland2.07362826
42MP0009278_abnormal_bone_marrow2.00880702
43MP0002638_abnormal_pupillary_reflex1.99761777
44MP0005451_abnormal_body_composition1.97080830
45MP0001800_abnormal_humoral_immune1.93330111
46MP0002723_abnormal_immune_serum1.88103754
47MP0002420_abnormal_adaptive_immunity1.88036892
48MP0002078_abnormal_glucose_homeostasis1.86932929
49MP0001819_abnormal_immune_cell1.86862264
50MP0002398_abnormal_bone_marrow1.77892132
51MP0002722_abnormal_immune_system1.76770753
52MP0000689_abnormal_spleen_morphology1.76696522
53MP0003283_abnormal_digestive_organ1.76022345
54MP0005000_abnormal_immune_tolerance1.72178278
55MP0001853_heart_inflammation1.71857716
56MP0003866_abnormal_defecation1.71822629
57MP0001666_abnormal_nutrient_absorption1.70196594
58MP0002118_abnormal_lipid_homeostasis1.69788957
59MP0002452_abnormal_antigen_presenting1.69362944
60MP0005332_abnormal_amino_acid1.66716141
61MP0005257_abnormal_intraocular_pressure1.66386054
62MP0009643_abnormal_urine_homeostasis1.66219111
63MP0000609_abnormal_liver_physiology1.61634826
64MP0002148_abnormal_hypersensitivity_rea1.58897407
65MP0000003_abnormal_adipose_tissue1.53004532
66MP0003566_abnormal_cell_adhesion1.50279011
67MP0003183_abnormal_peptide_metabolism1.50119327
68MP0000716_abnormal_immune_system1.49856456
69MP0001764_abnormal_homeostasis1.49432136
70MP0002429_abnormal_blood_cell1.46675205
71MP0002277_abnormal_respiratory_mucosa1.45885486
72MP0001986_abnormal_taste_sensitivity1.45326041
73MP0001533_abnormal_skeleton_physiology1.43839712
74MP0008004_abnormal_stomach_pH1.43585062
75MP0009333_abnormal_splenocyte_physiolog1.40793642
76MP0000703_abnormal_thymus_morphology1.39486938
77MP0009785_altered_susceptibility_to1.38998017
78MP0000579_abnormal_nail_morphology1.34813075
79MP0000678_abnormal_parathyroid_gland1.32880264
80MP0010155_abnormal_intestine_physiology1.30873822
81MP0003828_pulmonary_edema1.28490118
82MP0005636_abnormal_mineral_homeostasis1.27572429
83MP0001845_abnormal_inflammatory_respons1.26974905
84MP0000685_abnormal_immune_system1.25148219
85MP0005083_abnormal_biliary_tract1.24134400
86MP0004019_abnormal_vitamin_homeostasis1.23403854
87MP0002405_respiratory_system_inflammati1.22096610
88MP0001790_abnormal_immune_system1.21398047
89MP0005387_immune_system_phenotype1.21398047
90MP0004264_abnormal_extraembryonic_tissu1.21103063
91MP0004381_abnormal_hair_follicle1.20267255
92MP0005167_abnormal_blood-brain_barrier1.19903003
93MP0005058_abnormal_lysosome_morphology1.18958879
94MP0004947_skin_inflammation1.16272952
95MP0003763_abnormal_thymus_physiology1.14388772
96MP0000538_abnormal_urinary_bladder1.14219581
97MP0005310_abnormal_salivary_gland1.11582836
98MP0008874_decreased_physiological_sensi1.11015498
99MP0005666_abnormal_adipose_tissue1.10407637
100MP0001756_abnormal_urination1.10336391
101MP0005535_abnormal_body_temperature1.10288524
102MP0005671_abnormal_response_to1.10197525
103MP0003953_abnormal_hormone_level1.10090891
104MP0003646_muscle_fatigue1.08418823
105MP0003693_abnormal_embryo_hatching1.07686021
106MP0003300_gastrointestinal_ulcer1.06881784
107MP0009840_abnormal_foam_cell1.06697329
108MP0009764_decreased_sensitivity_to1.06372017
109MP0003123_paternal_imprinting1.04956838
110MP0001765_abnormal_ion_homeostasis1.04768878
111MP0002733_abnormal_thermal_nociception0.99815858
112MP0003191_abnormal_cellular_cholesterol0.97101910
113MP0009765_abnormal_xenobiotic_induced0.95422523
114MP0005253_abnormal_eye_physiology0.94362186
115MP0005501_abnormal_skin_physiology0.91198689
116MP0005408_hypopigmentation0.91096740
117MP0005319_abnormal_enzyme/_coenzyme0.90813604
118MP0001873_stomach_inflammation0.90335264
119MP0002163_abnormal_gland_morphology0.90326494
120MP0001663_abnormal_digestive_system0.90094882
121MP0001502_abnormal_circadian_rhythm0.88161362
122MP0005584_abnormal_enzyme/coenzyme_acti0.88157450
123MP0000313_abnormal_cell_death0.86999366
124MP0003075_altered_response_to0.85742745
125MP0000681_abnormal_thyroid_gland0.84400814
126MP0009642_abnormal_blood_homeostasis0.83989388
127MP0001299_abnormal_eye_distance/0.82258638
128MP0006035_abnormal_mitochondrial_morpho0.81253373
129MP0005075_abnormal_melanosome_morpholog0.80674874
130MP0002019_abnormal_tumor_incidence0.78292224
131MP0006082_CNS_inflammation0.77420367
132MP0006036_abnormal_mitochondrial_physio0.76642821
133MP0003787_abnormal_imprinting0.76630382
134MP0002735_abnormal_chemical_nociception0.75091127
135MP0002295_abnormal_pulmonary_circulatio0.75028404
136MP0009672_abnormal_birth_weight0.74901649
137MP0004883_abnormal_blood_vessel0.74668070
138MP0000639_abnormal_adrenal_gland0.74377473
139MP0003186_abnormal_redox_activity0.73842215
140MP0010307_abnormal_tumor_latency0.71290617
141MP0004130_abnormal_muscle_cell0.70849268
142MP0000750_abnormal_muscle_regeneration0.70807154
143MP0002751_abnormal_autonomic_nervous0.69616555
144MP0003638_abnormal_response/metabolism_0.69450895
145MP0009697_abnormal_copulation0.69081724
146MP0002254_reproductive_system_inflammat0.68307930
147MP0000858_altered_metastatic_potential0.68180638
148MP0003329_amyloid_beta_deposits0.67204124
149MP0003011_delayed_dark_adaptation0.66271783
150MP0002928_abnormal_bile_duct0.65829394
151MP0000470_abnormal_stomach_morphology0.65498787
152MP0001177_atelectasis0.64961292
153MP0003879_abnormal_hair_cell0.64035715
154MP0009931_abnormal_skin_appearance0.63860505
155MP0005334_abnormal_fat_pad0.63857677
156MP0005646_abnormal_pituitary_gland0.63096384
157MP0002736_abnormal_nociception_after0.62686495
158MP0000604_amyloidosis0.62107321
159MP0000598_abnormal_liver_morphology0.62015790
160MP0009763_increased_sensitivity_to0.60123358
161MP0003448_altered_tumor_morphology0.59695389
162MP0003121_genomic_imprinting0.58612211
163MP0001664_abnormal_digestion0.58117970
164MP0003656_abnormal_erythrocyte_physiolo0.57623255
165MP0004782_abnormal_surfactant_physiolog0.56668086
166MP0002896_abnormal_bone_mineralization0.56289383
167MP0003705_abnormal_hypodermis_morpholog0.54491789
168MP0004270_analgesia0.53403854
169MP0005375_adipose_tissue_phenotype0.52495868
170MP0000230_abnormal_systemic_arterial0.51683259
171MP0005448_abnormal_energy_balance0.51096911
172MP0006292_abnormal_olfactory_placode0.50444742
173MP0000613_abnormal_salivary_gland0.49421982
174MP0010368_abnormal_lymphatic_system0.49240466
175MP0000631_abnormal_neuroendocrine_gland0.47523117
176MP0008469_abnormal_protein_level0.46996739
177MP0005084_abnormal_gallbladder_morpholo0.46610042
178MP0008961_abnormal_basal_metabolism0.43409238
179MP0001661_extended_life_span0.42895469
180MP0001881_abnormal_mammary_gland0.42716116
181MP0009703_decreased_birth_body0.41713716
182MP0003959_abnormal_lean_body0.41666816
183MP0001851_eye_inflammation0.41042945
184MP0002971_abnormal_brown_adipose0.39966159

Predicted human phenotypes

RankGene SetZ-score
1Petechiae (HP:0000967)9.65794543
2Abnormal platelet volume (HP:0011876)7.63138436
3Prolonged bleeding time (HP:0003010)7.54191157
4Increased mean platelet volume (HP:0011877)7.47664841
5Purpura (HP:0000979)6.70656669
6Menorrhagia (HP:0000132)6.57960081
7Prolonged partial thromboplastin time (HP:0003645)6.39185035
8Abnormality of aromatic amino acid family metabolism (HP:0004338)6.21530936
9Hypoglycemic seizures (HP:0002173)6.18994572
10Hypoglycemic coma (HP:0001325)5.54712305
11Hyperinsulinemic hypoglycemia (HP:0000825)5.52028173
12Recurrent abscess formation (HP:0002722)5.47900271
13Gingival bleeding (HP:0000225)5.16276901
14Symptomatic seizures (HP:0011145)5.11186993
15Epistaxis (HP:0000421)4.87509091
16Abnormal platelet function (HP:0011869)4.84984792
17Impaired platelet aggregation (HP:0003540)4.84984792
18Joint hemorrhage (HP:0005261)4.79625049
19Obstructive lung disease (HP:0006536)4.70950374
20Chronic obstructive pulmonary disease (HP:0006510)4.70950374
21Intrahepatic cholestasis (HP:0001406)4.67892651
22Recurrent bacterial skin infections (HP:0005406)4.53804964
23Abnormality of the intrinsic pathway (HP:0010989)4.45955625
24Hyperthyroidism (HP:0000836)4.44102453
25Abnormality of monocarboxylic acid metabolism (HP:0010996)4.41712348
26Mucopolysacchariduria (HP:0008155)4.20429375
27Urinary glycosaminoglycan excretion (HP:0003541)4.20429375
28Deep venous thrombosis (HP:0002625)3.89902104
29Hyperglycemia (HP:0003074)3.84660412
30Ketoacidosis (HP:0001993)3.80038783
31Elevated erythrocyte sedimentation rate (HP:0003565)3.76365554
32Late onset (HP:0003584)3.75350578
33Eczematoid dermatitis (HP:0000976)3.75329993
34Abnormality of mucopolysaccharide metabolism (HP:0011020)3.74803511
35Abnormality of polysaccharide metabolism (HP:0011012)3.74803511
36Abnormality of glycosaminoglycan metabolism (HP:0004371)3.74803511
37Abnormality of macrophages (HP:0004311)3.37378021
38Recurrent skin infections (HP:0001581)3.35365776
39Complement deficiency (HP:0004431)3.33521679
40Myositis (HP:0100614)3.31904701
41Seborrheic dermatitis (HP:0001051)3.31474712
42Recurrent fungal infections (HP:0002841)3.31362125
43Xanthomatosis (HP:0000991)3.27749087
44Ketosis (HP:0001946)3.20774285
45Chronic mucocutaneous candidiasis (HP:0002728)3.18052398
46Recurrent cutaneous fungal infections (HP:0011370)3.18052398
47Dysostosis multiplex (HP:0000943)3.17980474
48Large for gestational age (HP:0001520)3.15394191
49Stomatitis (HP:0010280)3.14271590
50Conjugated hyperbilirubinemia (HP:0002908)3.10366198
51Hypertensive crisis (HP:0100735)3.05153607
52Abnormality of the common coagulation pathway (HP:0010990)3.02280584
53Panhypogammaglobulinemia (HP:0003139)2.97114794
54Global brain atrophy (HP:0002283)2.96727458
55Abnormality of endocrine pancreas physiology (HP:0012093)2.94188017
56Abnormality of the pancreatic islet cells (HP:0006476)2.94188017
57Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.91084911
58Epidermoid cyst (HP:0200040)2.90294344
59Abnormal delayed hypersensitivity skin test (HP:0002963)2.83825011
60Orchitis (HP:0100796)2.81453642
61Meningitis (HP:0001287)2.76740474
62Abnormality of glutamine family amino acid metabolism (HP:0010902)2.72011060
63Recurrent gram-negative bacterial infections (HP:0005420)2.70730913
64Limb hypertonia (HP:0002509)2.68128533
65Increased neuronal autofluorescent lipopigment (HP:0002074)2.67592425
66Viral hepatitis (HP:0006562)2.63756323
67Gastrointestinal inflammation (HP:0004386)2.63664591
68Insulin-resistant diabetes mellitus (HP:0000831)2.63632413
69Cervical subluxation (HP:0003308)2.61652894
70Spastic paraparesis (HP:0002313)2.57238440
71Episodic fever (HP:0001954)2.56961554
72Abnormality of calcium-phosphate metabolism (HP:0100530)2.56405131
73Meningioma (HP:0002858)2.55914348
74Hypobetalipoproteinemia (HP:0003563)2.55507899
75Mediastinal lymphadenopathy (HP:0100721)2.54727041
76Chronic otitis media (HP:0000389)2.53252502
77Hyperlipoproteinemia (HP:0010980)2.51317424
78Agitation (HP:0000713)2.51179634
79Cellulitis (HP:0100658)2.47618665
80Inflammation of the large intestine (HP:0002037)2.46754772
81Cutaneous melanoma (HP:0012056)2.46555852
82Split foot (HP:0001839)2.46253350
83Hepatosplenomegaly (HP:0001433)2.45854055
84Abnormality of the heme biosynthetic pathway (HP:0010472)2.43651693
85Hypoparathyroidism (HP:0000829)2.43562926
86Recurrent viral infections (HP:0004429)2.43104991
87Reduced antithrombin III activity (HP:0001976)2.41561764
88Urticaria (HP:0001025)2.41193789
89Severe visual impairment (HP:0001141)2.40724431
90Aplasia/Hypoplasia of the thymus (HP:0010515)2.37921973
91Encephalitis (HP:0002383)2.36309376
92Generalized hyperpigmentation (HP:0007440)2.35894692
93Fat malabsorption (HP:0002630)2.35179580
94Retrobulbar optic neuritis (HP:0100654)2.35031505
95Optic neuritis (HP:0100653)2.35031505
96Gout (HP:0001997)2.32792658
97Increased cerebral lipofuscin (HP:0011813)2.31906380
98Generalized aminoaciduria (HP:0002909)2.29706857
99Abnormality of complement system (HP:0005339)2.29348158
100Gingivitis (HP:0000230)2.29139231
101Abnormality of methionine metabolism (HP:0010901)2.27079184
102Hypothermia (HP:0002045)2.26694990
103Truncus arteriosus (HP:0001660)2.26282830
104Leukocytosis (HP:0001974)2.26225796
105Insulin resistance (HP:0000855)2.25889621
106Disproportionate short-trunk short stature (HP:0003521)2.24872381
107Irritability (HP:0000737)2.24115698
108Decreased circulating renin level (HP:0003351)2.23218246
109Mitral stenosis (HP:0001718)2.22765712
110Tetraparesis (HP:0002273)2.22593274
111Acute lymphatic leukemia (HP:0006721)2.22138983
112Gastrointestinal infarctions (HP:0005244)2.20175272
113Increased IgE level (HP:0003212)2.19924607
114Abnormality of purine metabolism (HP:0004352)2.19521525
115Micronodular cirrhosis (HP:0001413)2.18889554
116Systemic lupus erythematosus (HP:0002725)2.18583877
117Beaking of vertebral bodies (HP:0004568)2.16513384
118Hyperkalemia (HP:0002153)2.15186284
119Abnormality of macular pigmentation (HP:0008002)2.13791624
120Hyperbilirubinemia (HP:0002904)2.13585095
121Conjunctival hamartoma (HP:0100780)2.09317723
122Abnormality of iron homeostasis (HP:0011031)2.08847146
123Arterial thrombosis (HP:0004420)2.08813194
124Impaired proprioception (HP:0010831)2.08664089
125Agammaglobulinemia (HP:0004432)2.07496901
126Cholecystitis (HP:0001082)2.05932149
127Abnormal gallbladder physiology (HP:0012438)2.05932149
128Pancreatic islet-cell hyperplasia (HP:0004510)2.05808405
129Colitis (HP:0002583)2.05392975
130Neurodegeneration (HP:0002180)2.04574797
131Abnormality of sulfur amino acid metabolism (HP:0004339)2.02893835
132Abnormality of aspartate family amino acid metabolism (HP:0010899)2.00729510
133Enlarged kidneys (HP:0000105)2.00140691
134Testicular atrophy (HP:0000029)1.99265243
135Hypolipoproteinemia (HP:0010981)1.97698240
136Abnormality of the thymus (HP:0000777)1.97133551
137Abnormality of the peritoneum (HP:0002585)1.94289659
138Bowel incontinence (HP:0002607)1.93260206
139Ovoid vertebral bodies (HP:0003300)1.92900563
140Bone cyst (HP:0012062)1.92035498
141Abnormality of T cell physiology (HP:0011840)1.91591261
142Paraparesis (HP:0002385)1.91471184
143Pheochromocytoma (HP:0002666)1.91405630
144Abnormality of nucleobase metabolism (HP:0010932)1.91228268
145Glomerulonephritis (HP:0000099)1.91123201
146Hyperglycinemia (HP:0002154)1.90842246
147Abnormality of the tricuspid valve (HP:0001702)1.90457930
148Abnormal large intestine physiology (HP:0012700)1.90448048
149Atelectasis (HP:0100750)1.90095859
150Chest pain (HP:0100749)1.89733700
151Cerebral edema (HP:0002181)1.89715130
152Hypoalphalipoproteinemia (HP:0003233)1.89524776
153Hyperammonemia (HP:0001987)1.89056469
154Abnormality of proline metabolism (HP:0010907)1.89034988
155Hydroxyprolinuria (HP:0003080)1.89034988
156Hypocalcemia (HP:0002901)1.88735172
157Increased serum ferritin (HP:0003281)1.88143303
158Abnormality of urine glucose concentration (HP:0011016)1.84003894
159Glycosuria (HP:0003076)1.84003894
160Abnormality of transition element cation homeostasis (HP:0011030)1.83695028
161Alkalosis (HP:0001948)1.82775322
162Acne (HP:0001061)1.82634335
163Abnormal protein glycosylation (HP:0012346)1.82200144
164Abnormal glycosylation (HP:0012345)1.82200144
165Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.82200144
166Abnormal protein N-linked glycosylation (HP:0012347)1.82200144
167Osteomalacia (HP:0002749)1.81583745
168Skin nodule (HP:0200036)1.80746991
169Congenital glaucoma (HP:0001087)1.80187892
170Lethargy (HP:0001254)1.79456187
171Abnormal enzyme/coenzyme activity (HP:0012379)1.79304234
172Hypochromic anemia (HP:0001931)1.78761695
173Progressive neurologic deterioration (HP:0002344)1.78235554
174Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.77867848
175Hyperglycinuria (HP:0003108)1.76916735
176Type I transferrin isoform profile (HP:0003642)1.75068569
177Delayed CNS myelination (HP:0002188)1.74437989
178Tinnitus (HP:0000360)1.72777734
179Pancreatitis (HP:0001733)1.71496192
180Hepatitis (HP:0012115)1.71321508
181Abdominal distention (HP:0003270)1.70138238
182Polygenic inheritance (HP:0010982)1.69706213
183Hyperactive renin-angiotensin system (HP:0000841)1.69047751
184Intestinal atresia (HP:0011100)1.68634458
185Acute myeloid leukemia (HP:0004808)1.68204380
186Anteriorly placed anus (HP:0001545)1.67629877
187Aplasia/Hypoplasia of the earlobes (HP:0009906)1.66903442
188Bruising susceptibility (HP:0000978)1.66676156
189Granulocytopenia (HP:0001913)1.63899909
190Elevated alkaline phosphatase (HP:0003155)1.63497836
191Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.62389935
192Respiratory difficulties (HP:0002880)1.62222379
193Amyloidosis (HP:0011034)1.61679320
194Abnormality of alkaline phosphatase activity (HP:0004379)1.60406052
195Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.59349680
196Vasculitis (HP:0002633)1.56777596
197Aplasia/Hypoplasia of the sacrum (HP:0008517)1.53773435
198Abnormality of T cells (HP:0002843)1.53677531
199Microcytic anemia (HP:0001935)1.53534185

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME15.08942193
2IRAK24.75745537
3INSRR4.75064064
4STK164.69908514
5MAP2K33.45609473
6TRIB33.44254026
7IRAK43.32626294
8TESK23.08043792
9WNK42.99201985
10FRK2.71480785
11RIPK42.60686186
12VRK22.59931246
13MAP3K112.53046488
14GRK62.52572026
15PASK2.49815552
16BRAF2.45770957
17MAPK152.41496211
18SIK32.30192824
19HIPK22.28092760
20MAP2K22.23226092
21MAP3K22.21268484
22PKN22.19318047
23TAOK32.13557519
24TBK12.11897936
25KIT2.04388497
26MAP4K11.98894884
27BCKDK1.97663755
28FES1.79109577
29BLK1.72135444
30ERN11.65010384
31ARAF1.64906984
32SMG11.63230566
33PTK61.55841410
34TXK1.55601813
35IKBKE1.54904538
36ZAP701.52245502
37FLT31.51533305
38SIK21.49248134
39IKBKB1.41422387
40TLK11.40796951
41RPS6KB21.38708371
42WNK31.36814654
43DYRK1A1.29195759
44IRAK11.26647148
45NTRK31.26330269
46BTK1.24395325
47SYK1.21956661
48DYRK1B1.21498426
49RIPK11.20420737
50SCYL21.18937567
51CDC42BPA1.18717369
52BMPR21.17770273
53ACVR1B1.16339715
54HCK1.16067062
55KSR21.14504107
56CSK1.13325830
57MAP3K31.12489666
58TEC1.08889356
59FGFR41.04575609
60EPHB11.00957065
61PIK3CG0.99428841
62MATK0.98401358
63CSF1R0.98224195
64LYN0.96706797
65LRRK20.95968413
66ZAK0.94141251
67MAP2K10.93731690
68RPS6KA60.92261404
69NTRK10.88364522
70BMPR1B0.87585880
71UHMK10.86511934
72ERBB40.86086615
73TAOK20.86032337
74PRKD30.85860642
75WNK10.80857529
76RPS6KC10.79643594
77RPS6KL10.79643594
78EPHA20.79201844
79GSK3A0.77883794
80MET0.77759548
81CDK70.76230353
82MAP2K60.75566265
83STK38L0.74649497
84LCK0.74531749
85PRPF4B0.74092831
86CAMKK10.73343325
87YES10.71827842
88CAMKK20.71812249
89PDPK10.71441569
90EPHA30.69009356
91PRKD20.68416831
92NUAK10.68316835
93NLK0.66198807
94ITK0.66077600
95PRKCE0.65989464
96JAK20.64995834
97MAP3K60.60980577
98TAOK10.60698309
99JAK10.60374449
100DAPK20.58731413
101PRKCQ0.58363670
102MARK30.55663758
103PTK20.55578649
104ALK0.54011229
105CAMK2G0.53591966
106RPS6KA40.52599504
107PTK2B0.52040309
108PIM20.50640909
109PDK10.49504736
110PRKCD0.48899449
111GRK50.48244111
112VRK10.47050703
113PIK3CA0.47009988
114MAPK110.45676246
115MAPK40.45168881
116PRKACG0.43194855
117IRAK30.42590050
118DAPK10.42344000
119RET0.41911776
120AKT30.41625279
121STK40.40993329
122NEK90.40065768
123PRKCH0.39739600
124TYK20.39692796
125NME20.39564916
126JAK30.38650741
127KDR0.38650572
128MAP3K10.38643283
129MAPK30.38262166
130MAP3K140.38104014
131CHUK0.38078955
132SIK10.37939371
133MAPKAPK20.37886623
134PRKCZ0.37652057
135CAMK2B0.37431642
136PRKD10.34215434
137DYRK30.33480197
138ILK0.33044647
139MAP3K80.32171320
140PAK30.31826565
141CAMK2D0.31132980
142MAP2K40.30716664
143CDK120.30679204
144PRKACA0.30075378
145PRKAA10.30035612
146MARK20.30021405
147CDK50.28922742
148RPS6KA10.28253116
149RAF10.27183874
150TNK20.26946754
151SGK10.25903696
152AKT10.25826547
153STK240.25057223
154PRKAA20.24394255
155IGF1R0.24310725
156PKN10.22465625
157MAP3K100.22049605
158MST40.21911703
159MUSK0.21747979
160PRKCA0.19484156
161RPS6KA30.19358254
162ERBB30.19054922
163MAPKAPK30.19049598
164MAPK100.18661230
165PRKG10.17783466
166ADRBK20.17482099
167RPS6KA20.17310340

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.13535641
2Sulfur metabolism_Homo sapiens_hsa009204.54698603
3Selenocompound metabolism_Homo sapiens_hsa004503.47711653
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.20025970
5Platelet activation_Homo sapiens_hsa046112.99703445
6Protein export_Homo sapiens_hsa030602.99448574
7Acute myeloid leukemia_Homo sapiens_hsa052212.73382247
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.57909187
9Leishmaniasis_Homo sapiens_hsa051402.53569698
10B cell receptor signaling pathway_Homo sapiens_hsa046622.50982980
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.48502560
12Hematopoietic cell lineage_Homo sapiens_hsa046402.46468546
13Osteoclast differentiation_Homo sapiens_hsa043802.45047218
14Legionellosis_Homo sapiens_hsa051342.35800198
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.33713151
16Nitrogen metabolism_Homo sapiens_hsa009102.30117601
17Tryptophan metabolism_Homo sapiens_hsa003802.26731024
18NOD-like receptor signaling pathway_Homo sapiens_hsa046212.26637288
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.12652740
20Complement and coagulation cascades_Homo sapiens_hsa046102.12441479
21Folate biosynthesis_Homo sapiens_hsa007902.04753662
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.99671930
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.98981105
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.97041669
25Arginine biosynthesis_Homo sapiens_hsa002201.91965331
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.87237760
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.86679660
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.84111084
29Histidine metabolism_Homo sapiens_hsa003401.78688494
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.77616622
31Tuberculosis_Homo sapiens_hsa051521.75189345
32Base excision repair_Homo sapiens_hsa034101.72304002
33Fatty acid degradation_Homo sapiens_hsa000711.68208621
34Measles_Homo sapiens_hsa051621.66067374
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.62982154
36Pentose phosphate pathway_Homo sapiens_hsa000301.59791785
37Non-small cell lung cancer_Homo sapiens_hsa052231.58342272
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.58034794
39Insulin secretion_Homo sapiens_hsa049111.57204358
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54852862
41Starch and sucrose metabolism_Homo sapiens_hsa005001.47786756
42Phenylalanine metabolism_Homo sapiens_hsa003601.47190951
43Chemokine signaling pathway_Homo sapiens_hsa040621.44834562
44Butanoate metabolism_Homo sapiens_hsa006501.43958737
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.41336550
46ABC transporters_Homo sapiens_hsa020101.39058576
47Influenza A_Homo sapiens_hsa051641.29108678
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.28660552
49TNF signaling pathway_Homo sapiens_hsa046681.28635389
50Hepatitis B_Homo sapiens_hsa051611.27349363
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26574041
52Chronic myeloid leukemia_Homo sapiens_hsa052201.25247653
53Ribosome_Homo sapiens_hsa030101.24671998
54Tyrosine metabolism_Homo sapiens_hsa003501.23006067
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.20159476
56beta-Alanine metabolism_Homo sapiens_hsa004101.19478045
57Other glycan degradation_Homo sapiens_hsa005111.18416613
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17714447
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17303097
60Primary immunodeficiency_Homo sapiens_hsa053401.15442401
61Propanoate metabolism_Homo sapiens_hsa006401.13447959
62Fat digestion and absorption_Homo sapiens_hsa049751.10010592
63Hepatitis C_Homo sapiens_hsa051601.09012755
64Herpes simplex infection_Homo sapiens_hsa051681.08176752
65Linoleic acid metabolism_Homo sapiens_hsa005911.07928671
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07705847
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05674265
68Malaria_Homo sapiens_hsa051441.04331432
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02665879
70Pancreatic cancer_Homo sapiens_hsa052121.02410260
71Arachidonic acid metabolism_Homo sapiens_hsa005901.02147561
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01558186
73Dorso-ventral axis formation_Homo sapiens_hsa043200.99999964
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.99740761
75Peroxisome_Homo sapiens_hsa041460.99696516
76T cell receptor signaling pathway_Homo sapiens_hsa046600.99102012
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.98918366
78Lysosome_Homo sapiens_hsa041420.98684096
79Fatty acid metabolism_Homo sapiens_hsa012120.98627508
80DNA replication_Homo sapiens_hsa030300.97914157
81Notch signaling pathway_Homo sapiens_hsa043300.96401172
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.95693338
83Vibrio cholerae infection_Homo sapiens_hsa051100.94757259
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94251831
85Staphylococcus aureus infection_Homo sapiens_hsa051500.93876238
86Inositol phosphate metabolism_Homo sapiens_hsa005620.92824521
87mTOR signaling pathway_Homo sapiens_hsa041500.91216537
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.91003525
89Endometrial cancer_Homo sapiens_hsa052130.90788250
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.90586613
91Epstein-Barr virus infection_Homo sapiens_hsa051690.88880678
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88843199
93Endocytosis_Homo sapiens_hsa041440.87911981
94PPAR signaling pathway_Homo sapiens_hsa033200.87470605
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85570671
96Type II diabetes mellitus_Homo sapiens_hsa049300.84688665
97Apoptosis_Homo sapiens_hsa042100.82443325
98Glucagon signaling pathway_Homo sapiens_hsa049220.81836336
99Viral carcinogenesis_Homo sapiens_hsa052030.81144442
100Sulfur relay system_Homo sapiens_hsa041220.80487118
101Toxoplasmosis_Homo sapiens_hsa051450.78619905
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77698992
103Prion diseases_Homo sapiens_hsa050200.76739638
104Salmonella infection_Homo sapiens_hsa051320.75271255
105Bile secretion_Homo sapiens_hsa049760.74662745
106Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74507535
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.73734167
108N-Glycan biosynthesis_Homo sapiens_hsa005100.73643800
109Fatty acid elongation_Homo sapiens_hsa000620.73233879
110Galactose metabolism_Homo sapiens_hsa000520.73209912
111Sphingolipid metabolism_Homo sapiens_hsa006000.73106505
112Chemical carcinogenesis_Homo sapiens_hsa052040.72783773
113Small cell lung cancer_Homo sapiens_hsa052220.72569227
114Taste transduction_Homo sapiens_hsa047420.68771537
115African trypanosomiasis_Homo sapiens_hsa051430.64932876
116Caffeine metabolism_Homo sapiens_hsa002320.63939445
117Proteasome_Homo sapiens_hsa030500.62330461
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60961669
119Arginine and proline metabolism_Homo sapiens_hsa003300.60841793
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.60421109
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60289828
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.56482453
123VEGF signaling pathway_Homo sapiens_hsa043700.56160321
124Insulin resistance_Homo sapiens_hsa049310.55788409
125Colorectal cancer_Homo sapiens_hsa052100.55616419
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54548221
127Bladder cancer_Homo sapiens_hsa052190.54546738
128Oxidative phosphorylation_Homo sapiens_hsa001900.53347419
129Pertussis_Homo sapiens_hsa051330.51599642
130Antigen processing and presentation_Homo sapiens_hsa046120.51273276
131Vitamin digestion and absorption_Homo sapiens_hsa049770.51174210
132Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50938173
133Retinol metabolism_Homo sapiens_hsa008300.48916271
134Pyruvate metabolism_Homo sapiens_hsa006200.48588713
135FoxO signaling pathway_Homo sapiens_hsa040680.47058394
136Cysteine and methionine metabolism_Homo sapiens_hsa002700.46503358
137Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46121437
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.45773404
139Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45664658
140Circadian rhythm_Homo sapiens_hsa047100.45475717
141Metabolic pathways_Homo sapiens_hsa011000.45145351
142Lysine degradation_Homo sapiens_hsa003100.44609968
143Collecting duct acid secretion_Homo sapiens_hsa049660.44595683
144Steroid biosynthesis_Homo sapiens_hsa001000.43884004
145Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42823341
146Cocaine addiction_Homo sapiens_hsa050300.42166551
147Type I diabetes mellitus_Homo sapiens_hsa049400.41319098
148Renal cell carcinoma_Homo sapiens_hsa052110.40306655
149Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40039861
150Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39833493
151Central carbon metabolism in cancer_Homo sapiens_hsa052300.39304608
152Glycerophospholipid metabolism_Homo sapiens_hsa005640.38486701
153Glycerolipid metabolism_Homo sapiens_hsa005610.37915331
154Shigellosis_Homo sapiens_hsa051310.37874932
155Spliceosome_Homo sapiens_hsa030400.37418412
156SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37200801
157Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37072759
158Pyrimidine metabolism_Homo sapiens_hsa002400.36627109
159Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35538572
160Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35251845
161Ether lipid metabolism_Homo sapiens_hsa005650.34776841
162Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33828812
163Glioma_Homo sapiens_hsa052140.33768365
164Regulation of autophagy_Homo sapiens_hsa041400.33716014
165Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32601541
166Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32227888
167Glutathione metabolism_Homo sapiens_hsa004800.31950656
168Prolactin signaling pathway_Homo sapiens_hsa049170.30129103
169Insulin signaling pathway_Homo sapiens_hsa049100.28286348
170Carbon metabolism_Homo sapiens_hsa012000.27698617
171Pancreatic secretion_Homo sapiens_hsa049720.27203348
172Thyroid hormone synthesis_Homo sapiens_hsa049180.26443481
173Vitamin B6 metabolism_Homo sapiens_hsa007500.25483358
174Alzheimers disease_Homo sapiens_hsa050100.24420126
175Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22483089
176Biosynthesis of amino acids_Homo sapiens_hsa012300.21373168
177Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.20047900
178Synaptic vesicle cycle_Homo sapiens_hsa047210.14865878
179Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.13127966
180Parkinsons disease_Homo sapiens_hsa050120.12874498

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