CIB4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.69846721
2epithelial cilium movement (GO:0003351)9.52462971
3axonemal dynein complex assembly (GO:0070286)9.08033571
4plasma membrane fusion (GO:0045026)9.01602365
5motile cilium assembly (GO:0044458)8.97222576
6reproduction (GO:0000003)8.79517862
7cilium or flagellum-dependent cell motility (GO:0001539)8.18909583
8regulation of cilium movement (GO:0003352)7.79976161
9cilium movement (GO:0003341)7.74110942
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.62397702
11sperm capacitation (GO:0048240)7.27233520
12negative regulation of inclusion body assembly (GO:0090084)7.21393851
13organic cation transport (GO:0015695)7.11226940
14synaptonemal complex assembly (GO:0007130)6.95055055
15piRNA metabolic process (GO:0034587)6.92746032
16spermatogenesis (GO:0007283)6.88526403
17single fertilization (GO:0007338)6.87944490
18synaptonemal complex organization (GO:0070193)6.87590546
19male gamete generation (GO:0048232)6.85798410
20microtubule depolymerization (GO:0007019)6.66179602
21male meiosis (GO:0007140)6.44905840
22gamete generation (GO:0007276)6.29117084
23fertilization (GO:0009566)6.12819577
24opioid receptor signaling pathway (GO:0038003)6.02493114
25G-protein coupled glutamate receptor signaling pathway (GO:0007216)5.90589570
26chromosome condensation (GO:0030261)5.85673541
27regulation of inclusion body assembly (GO:0090083)5.85373080
28calcium ion-dependent exocytosis (GO:0017156)5.73702632
29DNA packaging (GO:0006323)5.68416418
30cellular process involved in reproduction in multicellular organism (GO:0022412)5.33329535
31mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.30513284
32germ cell development (GO:0007281)5.28432717
33dopaminergic neuron differentiation (GO:0071542)5.24397350
34microtubule severing (GO:0051013)5.10079075
35lateral ventricle development (GO:0021670)5.05944194
36cell recognition (GO:0008037)4.97276077
37single strand break repair (GO:0000012)4.94377881
38multicellular organismal reproductive process (GO:0048609)4.94210602
39detection of temperature stimulus (GO:0016048)4.85886338
40chromosome organization involved in meiosis (GO:0070192)4.79117542
41intraciliary transport (GO:0042073)4.78719788
42ventricular system development (GO:0021591)4.61853334
43glycerol ether metabolic process (GO:0006662)4.61296553
44viral transcription (GO:0019083)4.61182529
45limb bud formation (GO:0060174)4.59277303
46male meiosis I (GO:0007141)4.58856813
47seminiferous tubule development (GO:0072520)4.49461042
48spermatid nucleus differentiation (GO:0007289)4.49422504
49establishment of protein localization to mitochondrial membrane (GO:0090151)4.49325974
50regulation of microtubule-based movement (GO:0060632)4.46990818
51translational termination (GO:0006415)4.40717521
52ATP synthesis coupled proton transport (GO:0015986)4.38864051
53energy coupled proton transport, down electrochemical gradient (GO:0015985)4.38864051
54DNA methylation involved in gamete generation (GO:0043046)4.35674675
55midbrain development (GO:0030901)4.31098248
56sequestering of actin monomers (GO:0042989)4.28202514
57ether metabolic process (GO:0018904)4.24676464
58enteric nervous system development (GO:0048484)4.21257711
59negative regulation of cytosolic calcium ion concentration (GO:0051481)4.15034578
60left/right pattern formation (GO:0060972)4.14120403
61sexual reproduction (GO:0019953)4.12827432
62multicellular organismal development (GO:0007275)4.12056878
63cotranslational protein targeting to membrane (GO:0006613)4.02215512
64atrial cardiac muscle cell action potential (GO:0086014)4.01069349
65SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.98934488
66meiotic nuclear division (GO:0007126)3.91985198
67purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.91476862
683-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.91476862
69protein targeting to ER (GO:0045047)3.91218314
70chaperone-mediated protein complex assembly (GO:0051131)3.84126598
71regulation of phospholipid biosynthetic process (GO:0071071)3.80251456
72peripheral nervous system axon ensheathment (GO:0032292)3.78815666
73myelination in peripheral nervous system (GO:0022011)3.78815666
74establishment of protein localization to endoplasmic reticulum (GO:0072599)3.76703602
75type B pancreatic cell development (GO:0003323)3.75227279
76polyamine biosynthetic process (GO:0006596)3.72088662
77serotonin receptor signaling pathway (GO:0007210)3.63039836
78kidney morphogenesis (GO:0060993)3.61654918
79interferon-gamma secretion (GO:0072643)3.61509619
80protein localization to endoplasmic reticulum (GO:0070972)3.59723096
81protein insertion into membrane (GO:0051205)3.59614839
82microtubule polymerization or depolymerization (GO:0031109)3.57390757
83meiosis I (GO:0007127)3.54090147
84determination of left/right symmetry (GO:0007368)3.53377453
85genitalia morphogenesis (GO:0035112)3.52431151
86translational elongation (GO:0006414)3.47303373
87negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.45706307
88specification of symmetry (GO:0009799)3.44375659
89intestinal epithelial cell development (GO:0060576)3.42484773
90regulation of spindle checkpoint (GO:0090231)3.41824451
91gamma-aminobutyric acid transport (GO:0015812)3.41089241
92RNA destabilization (GO:0050779)3.40020307
93otic vesicle formation (GO:0030916)3.37539062
94carnitine transport (GO:0015879)3.37147357
95amino-acid betaine transport (GO:0015838)3.37147357
96spinal cord motor neuron differentiation (GO:0021522)3.35935208
97protein neddylation (GO:0045116)3.35402960
98skeletal muscle organ development (GO:0060538)3.34853439
99determination of bilateral symmetry (GO:0009855)3.32314418
100ribosomal small subunit biogenesis (GO:0042274)3.32186328
101cGMP biosynthetic process (GO:0006182)3.29021023
102positive regulation of macrophage activation (GO:0043032)3.24598931
103protein polyglutamylation (GO:0018095)3.23138168
104mechanoreceptor differentiation (GO:0042490)3.22320772
105carnitine transmembrane transport (GO:1902603)3.21428656
106mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.15852336
107secondary metabolite biosynthetic process (GO:0044550)3.12672008
108respiratory electron transport chain (GO:0022904)3.12664977
109meiotic cell cycle (GO:0051321)3.12425240
110cellular protein complex disassembly (GO:0043624)3.10511740
111protein K11-linked deubiquitination (GO:0035871)3.10349829
112electron transport chain (GO:0022900)3.07100353
113diaphragm development (GO:0060539)3.06819036
114female gonad development (GO:0008585)3.05853528
115mannosylation (GO:0097502)3.04843001
116platelet dense granule organization (GO:0060155)3.03904295
117nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.03350474
118viral life cycle (GO:0019058)2.98987946
119lateral sprouting from an epithelium (GO:0060601)2.96669561
120activation of protein kinase B activity (GO:0032148)2.96347525
121response to gravity (GO:0009629)2.94301310
122RNA localization (GO:0006403)2.91579255
123sulfation (GO:0051923)2.90505397
124cardiac right ventricle morphogenesis (GO:0003215)2.90288906
125positive regulation of meiosis (GO:0045836)2.89304418
126alditol metabolic process (GO:0019400)2.87952265
127translational initiation (GO:0006413)2.86905205
128glycolytic process (GO:0006096)2.86693072
129regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.86336341
130regulation of respiratory gaseous exchange (GO:0043576)2.82794482
131hindbrain development (GO:0030902)2.80965113
132mitochondrial respiratory chain complex I assembly (GO:0032981)2.80010045
133NADH dehydrogenase complex assembly (GO:0010257)2.80010045
134mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.80010045
135protein localization to cilium (GO:0061512)2.79686634
136mitotic sister chromatid cohesion (GO:0007064)2.78437758
137nucleoside diphosphate phosphorylation (GO:0006165)2.78253003
138protein complex biogenesis (GO:0070271)2.77742610
139synapsis (GO:0007129)2.77200407
140protein refolding (GO:0042026)2.76605736
141mitochondrial respiratory chain complex assembly (GO:0033108)2.76470940
142behavioral response to cocaine (GO:0048148)2.75336994
143dentate gyrus development (GO:0021542)2.74577389
144artery smooth muscle contraction (GO:0014824)2.74257817
145dorsal/ventral pattern formation (GO:0009953)2.74097705
146regulation of cholesterol esterification (GO:0010872)2.73263818
147polyol catabolic process (GO:0046174)2.72329647
148positive regulation of meiotic cell cycle (GO:0051446)2.71724759
149meiotic cell cycle process (GO:1903046)2.70859015
150hydrogen ion transmembrane transport (GO:1902600)2.70197899
151urinary tract smooth muscle contraction (GO:0014848)2.67969515
152presynaptic membrane assembly (GO:0097105)2.66957826
153chaperone-mediated protein transport (GO:0072321)2.64783744
154cellular ketone body metabolic process (GO:0046950)2.62346101
155induction of positive chemotaxis (GO:0050930)2.61803389
156nucleus organization (GO:0006997)2.61087052
157regulation of cilium assembly (GO:1902017)2.60406926
158protein targeting to membrane (GO:0006612)2.58463299
159peptidyl-glutamic acid modification (GO:0018200)2.58435571
160chromatin silencing (GO:0006342)2.58095682
161positive regulation of TOR signaling (GO:0032008)2.57398222
162ventricular cardiac muscle cell development (GO:0055015)2.56116121
163membrane protein intracellular domain proteolysis (GO:0031293)2.54001535
164cilium organization (GO:0044782)2.53873665
165glutamate receptor signaling pathway (GO:0007215)2.53556385
166lung morphogenesis (GO:0060425)2.52511746
167smoothened signaling pathway (GO:0007224)2.52086875
168left/right axis specification (GO:0070986)2.51485035
169embryonic digestive tract morphogenesis (GO:0048557)2.50929207
170monoubiquitinated protein deubiquitination (GO:0035520)2.49572082
171regulation of acrosome reaction (GO:0060046)2.49357740
172amyloid precursor protein catabolic process (GO:0042987)2.49184423
173regulation of receptor internalization (GO:0002090)2.48505967
174cellular component assembly involved in morphogenesis (GO:0010927)2.48405723
175microtubule-based movement (GO:0007018)2.46544556
176cilium assembly (GO:0042384)2.43721799
177negative regulation of organelle assembly (GO:1902116)2.43046881
178glycerol metabolic process (GO:0006071)2.43046716
179cilium morphogenesis (GO:0060271)2.42382971
180amine biosynthetic process (GO:0009309)2.40507280
181cellular biogenic amine biosynthetic process (GO:0042401)2.40507280
182regulation of protein kinase C signaling (GO:0090036)2.39946393
183sperm motility (GO:0030317)13.6797776
184acrosome reaction (GO:0007340)12.8979071
185cell wall macromolecule metabolic process (GO:0044036)12.8512108
186cell wall macromolecule catabolic process (GO:0016998)12.8512108
187fusion of sperm to egg plasma membrane (GO:0007342)11.8911785
188acrosome assembly (GO:0001675)11.4677904
189sperm-egg recognition (GO:0035036)11.3579857
190binding of sperm to zona pellucida (GO:0007339)10.6029499
191cell-cell recognition (GO:0009988)10.1439463
192multicellular organism reproduction (GO:0032504)10.1285798

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.73118834
2EZH2_22144423_ChIP-Seq_EOC_Human4.88638369
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.67451183
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.55127340
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.42999705
6GBX2_23144817_ChIP-Seq_PC3_Human3.04163462
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.00099978
8FUS_26573619_Chip-Seq_HEK293_Human2.60775048
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.54050119
10GATA1_26923725_Chip-Seq_HPCs_Mouse2.33271804
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.31292858
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.29960723
13VDR_22108803_ChIP-Seq_LS180_Human2.22958007
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.20326091
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13418310
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.02277368
17GATA1_22025678_ChIP-Seq_K562_Human1.99366809
18EZH2_18974828_ChIP-Seq_MESCs_Mouse1.94824310
19RNF2_18974828_ChIP-Seq_MESCs_Mouse1.94824310
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.91352591
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.90660604
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90272042
23ZNF274_21170338_ChIP-Seq_K562_Hela1.88469185
24EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.88455149
25SALL1_21062744_ChIP-ChIP_HESCs_Human1.86487984
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.85316335
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.84249628
28KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.84226531
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.84026088
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.78282268
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.77544018
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76967529
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.74254323
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.72997095
35STAT1_17558387_ChIP-Seq_HELA_Human1.72922796
36MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.69708424
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68965308
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.68606530
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.68276023
40EWS_26573619_Chip-Seq_HEK293_Human1.66300152
41SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.59332325
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.58239747
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.57911955
44ELK4_26923725_Chip-Seq_MESODERM_Mouse1.57759954
45FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55950604
46BCAT_22108803_ChIP-Seq_LS180_Human1.52478595
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.52377051
48P300_19829295_ChIP-Seq_ESCs_Human1.51705451
49* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.51277736
50SOX2_22085726_ChIP-Seq_NPCs_Mouse1.50594934
51KDM2B_26808549_Chip-Seq_REH_Human1.50146917
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49834864
53REST_21632747_ChIP-Seq_MESCs_Mouse1.47189605
54CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.46140611
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44149546
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.43686846
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41480843
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.39581351
59GATA3_21867929_ChIP-Seq_CD8_Mouse1.36712171
60RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.36655252
61CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.36469863
62FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.36009626
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35643418
64TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.34760295
65RAD21_21589869_ChIP-Seq_MESCs_Mouse1.34356458
66TAL1_26923725_Chip-Seq_HPCs_Mouse1.34022362
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33582845
68CBP_20019798_ChIP-Seq_JUKART_Human1.33582845
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31829794
70P53_21459846_ChIP-Seq_SAOS-2_Human1.31756634
71EST1_17652178_ChIP-ChIP_JURKAT_Human1.30828686
72SMAD3_21741376_ChIP-Seq_HESCs_Human1.30650223
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.30343221
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30207152
75PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30205658
76CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.29439338
77SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.28992167
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26899127
79RING1B_27294783_Chip-Seq_ESCs_Mouse1.26892090
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26763071
81SMAD4_21799915_ChIP-Seq_A2780_Human1.26510731
82GF1_26923725_Chip-Seq_HPCs_Mouse1.25310596
83GATA3_21867929_ChIP-Seq_TH1_Mouse1.23990561
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23553879
85KAP1_22055183_ChIP-Seq_ESCs_Mouse1.23115037
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.23075476
87NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22985025
88RNF2_27304074_Chip-Seq_NSC_Mouse1.21058411
89RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20767494
90SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20407066
91GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.20072707
92AR_25329375_ChIP-Seq_VCAP_Human1.19725310
93CRX_20693478_ChIP-Seq_RETINA_Mouse1.19296052
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19025923
95ESR1_20079471_ChIP-ChIP_T-47D_Human1.17182256
96EP300_21415370_ChIP-Seq_HL-1_Mouse1.16991907
97WDR5_24793694_ChIP-Seq_LNCAP_Human1.16194173
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15379680
99P53_22387025_ChIP-Seq_ESCs_Mouse1.14341460
100PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13884293
101RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13176146
102SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12952700
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12744533
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12744533
105CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11114896
106HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10849118
107ER_23166858_ChIP-Seq_MCF-7_Human1.10784591
108SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10351130
109* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10036151
110CBP_21632823_ChIP-Seq_H3396_Human1.10031336
111SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09493634
112SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.09418515
113OCT4_18555785_Chip-Seq_ESCs_Mouse1.08810013
114STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08680911
115SOX11_22085726_ChIP-Seq_ESNs_Mouse1.08206752
116TP53_20018659_ChIP-ChIP_R1E_Mouse1.07034941
117LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.06962748
118JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.06523524
119TCF4_22108803_ChIP-Seq_LS180_Human1.05900187
120ESET_19884257_ChIP-Seq_ESCs_Mouse1.05899536
121MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05859605
122KLF4_18555785_Chip-Seq_ESCs_Mouse1.05540205
123EZH2_27294783_Chip-Seq_NPCs_Mouse1.04745790
124SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04373096
125MTF2_20144788_ChIP-Seq_MESCs_Mouse1.04110418
126MYC_27129775_Chip-Seq_CORNEA_Mouse1.04100183
127PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03790795
128* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03097079
129CMYC_18555785_Chip-Seq_ESCs_Mouse1.03025274
130EZH2_27294783_Chip-Seq_ESCs_Mouse1.02427553
131TET1_21451524_ChIP-Seq_MESCs_Mouse1.02082600
132* GATA3_21878914_ChIP-Seq_MCF-7_Human1.02069660
133PU1_27457419_Chip-Seq_LIVER_Mouse1.00953932
134RXRA_24833708_ChIP-Seq_LIVER_Mouse1.00728537
135RUNX1_26923725_Chip-Seq_HPCs_Mouse1.00492439
136EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00484859
137NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00044716
138ELK1_19687146_ChIP-ChIP_HELA_Human0.99922224
139SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99667748
140P300_18555785_Chip-Seq_ESCs_Mouse0.99579126
141CTCF_20526341_ChIP-Seq_ESCs_Human0.99297412
142NFYB_21822215_ChIP-Seq_K562_Human0.99249462
143ELK1_22589737_ChIP-Seq_MCF10A_Human0.98642421
144FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98583470
145SOX2_19829295_ChIP-Seq_ESCs_Human0.98379435
146NANOG_19829295_ChIP-Seq_ESCs_Human0.98379435
147NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97923778
148AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97809632
149CTCF_27219007_Chip-Seq_Bcells_Human0.97725929
150SPI1_26923725_Chip-Seq_HPCs_Mouse0.97452111
151OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96899758
152FLI1_21867929_ChIP-Seq_TH2_Mouse0.96616313
153SMAD4_21741376_ChIP-Seq_HESCs_Human0.96416689
154SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95412344
155EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.95402934
156FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94818858
157TAF15_26573619_Chip-Seq_HEK293_Human0.94714753
158RING1B_27294783_Chip-Seq_NPCs_Mouse0.94412632
159EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.94401134
160CDX2_22108803_ChIP-Seq_LS180_Human0.94138127
161ESRRB_18555785_Chip-Seq_ESCs_Mouse0.94048186
162STAT3_18555785_Chip-Seq_ESCs_Mouse0.93638811
163PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93468433
164* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.92763604
165ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91378313
166ETV1_20927104_ChIP-Seq_GIST48_Human0.91098368
167SOX2_18555785_Chip-Seq_ESCs_Mouse0.90994732
168RARA_24833708_ChIP-Seq_LIVER_Mouse0.90919969
169ARNT_22903824_ChIP-Seq_MCF-7_Human0.90299198
170PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90262890
171HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.90254502
172LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89831669

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis8.73962884
2MP0003283_abnormal_digestive_organ6.22268141
3MP0003698_abnormal_male_reproductive5.65247440
4MP0001929_abnormal_gametogenesis5.05774294
5MP0010030_abnormal_orbit_morphology3.91165684
6MP0003136_yellow_coat_color3.48194896
7MP0002161_abnormal_fertility/fecundity3.10474409
8MP0008877_abnormal_DNA_methylation2.99825883
9MP0002210_abnormal_sex_determination2.95479564
10MP0000372_irregular_coat_pigmentation2.95047766
11MP0005670_abnormal_white_adipose2.91339475
12MP0005187_abnormal_penis_morphology2.88688166
13MP0001145_abnormal_male_reproductive2.56448893
14MP0003315_abnormal_perineum_morphology2.46356416
15MP0002876_abnormal_thyroid_physiology2.33395729
16MP0003938_abnormal_ear_development2.33122921
17MP0000653_abnormal_sex_gland2.25611005
18MP0002938_white_spotting2.23244085
19MP0002638_abnormal_pupillary_reflex2.05777653
20MP0005410_abnormal_fertilization15.7518729
21MP0002160_abnormal_reproductive_system1.80035285
22MP0005171_absent_coat_pigmentation1.64962546
23MP0004233_abnormal_muscle_weight1.63932119
24MP0005646_abnormal_pituitary_gland1.50735204
25MP0001299_abnormal_eye_distance/1.50348349
26MP0003937_abnormal_limbs/digits/tail_de1.48044534
27MP0002234_abnormal_pharynx_morphology1.46419862
28MP0000026_abnormal_inner_ear1.44836714
29MP0002127_abnormal_cardiovascular_syste1.43691961
30MP0003646_muscle_fatigue1.38805007
31MP0004134_abnormal_chest_morphology1.33216558
32MP0000462_abnormal_digestive_system1.32820127
33MP0005084_abnormal_gallbladder_morpholo1.30762991
34MP0001765_abnormal_ion_homeostasis1.25980007
35MP0002108_abnormal_muscle_morphology1.20229798
36MP0005503_abnormal_tendon_morphology1.15368326
37MP0000537_abnormal_urethra_morphology1.14979102
38MP0002233_abnormal_nose_morphology1.10338717
39MP0002653_abnormal_ependyma_morphology1.08470846
40MP0002909_abnormal_adrenal_gland1.07644423
41MP0005423_abnormal_somatic_nervous1.04623091
42MP0002928_abnormal_bile_duct1.04575254
43MP0005197_abnormal_uvea_morphology1.04018022
44MP0004885_abnormal_endolymph1.03704808
45MP0001440_abnormal_grooming_behavior1.03500087
46MP0009379_abnormal_foot_pigmentation1.01516659
47MP0000428_abnormal_craniofacial_morphol1.00499965
48MP0006035_abnormal_mitochondrial_morpho0.99759516
49MP0009780_abnormal_chondrocyte_physiolo0.99635718
50MP0005623_abnormal_meninges_morphology0.99387532
51MP0005647_abnormal_sex_gland0.97786221
52MP0000647_abnormal_sebaceous_gland0.97344415
53MP0005389_reproductive_system_phenotype0.97326581
54MP0002090_abnormal_vision0.96712773
55MP0000639_abnormal_adrenal_gland0.96211382
56MP0005367_renal/urinary_system_phenotyp0.96014087
57MP0000516_abnormal_urinary_system0.96014087
58MP0001485_abnormal_pinna_reflex0.94311358
59MP0003632_abnormal_nervous_system0.94113374
60MP0000778_abnormal_nervous_system0.93394402
61MP0003879_abnormal_hair_cell0.93300760
62MP0001661_extended_life_span0.91993211
63MP0008058_abnormal_DNA_repair0.90860317
64MP0002932_abnormal_joint_morphology0.90650566
65MP0001188_hyperpigmentation0.86417697
66MP0003950_abnormal_plasma_membrane0.85874134
67MP0010368_abnormal_lymphatic_system0.84259383
68MP0004272_abnormal_basement_membrane0.83910461
69MP0000955_abnormal_spinal_cord0.83558851
70MP0005508_abnormal_skeleton_morphology0.83456776
71MP0001879_abnormal_lymphatic_vessel0.83271685
72MP0001963_abnormal_hearing_physiology0.82736587
73MP0009053_abnormal_anal_canal0.81399195
74MP0001984_abnormal_olfaction0.81287941
75MP0001346_abnormal_lacrimal_gland0.81091038
76MP0001286_abnormal_eye_development0.79450293
77MP0006276_abnormal_autonomic_nervous0.79259690
78MP0002009_preneoplasia0.78406963
79MP0005164_abnormal_response_to0.78387957
80MP0003385_abnormal_body_wall0.77069363
81MP0003935_abnormal_craniofacial_develop0.76297029
82MP0000762_abnormal_tongue_morphology0.76096474
83MP0004142_abnormal_muscle_tone0.76048978
84MP0004264_abnormal_extraembryonic_tissu0.75924208
85MP0003195_calcinosis0.73757651
86MP0002184_abnormal_innervation0.72750126
87MP0009250_abnormal_appendicular_skeleto0.71161714
88MP0000163_abnormal_cartilage_morphology0.70856522
89MP0002282_abnormal_trachea_morphology0.70338604
90MP0005636_abnormal_mineral_homeostasis0.69636598
91MP0001270_distended_abdomen0.68680702
92MP0009745_abnormal_behavioral_response0.65956009
93MP0009046_muscle_twitch0.65226502
94MP0004019_abnormal_vitamin_homeostasis0.64167774
95MP0002109_abnormal_limb_morphology0.63670959
96MP0004085_abnormal_heartbeat0.63170109
97MP0001501_abnormal_sleep_pattern0.63076629
98MP0005448_abnormal_energy_balance0.62265647
99MP0003011_delayed_dark_adaptation0.61750834
100MP0000767_abnormal_smooth_muscle0.61579252
101MP0005551_abnormal_eye_electrophysiolog0.58690364
102MP0000534_abnormal_ureter_morphology0.58340095
103MP0005253_abnormal_eye_physiology0.58243216
104MP0006072_abnormal_retinal_apoptosis0.55199355
105MP0001324_abnormal_eye_pigmentation0.55130140
106MP0005666_abnormal_adipose_tissue0.52370010
107MP0000049_abnormal_middle_ear0.51650938
108MP0005391_vision/eye_phenotype0.46801254
109MP0003115_abnormal_respiratory_system0.46137688
110MP0000427_abnormal_hair_cycle0.45026332
111MP0003119_abnormal_digestive_system0.44461584
112MP0002751_abnormal_autonomic_nervous0.43443169
113MP0006036_abnormal_mitochondrial_physio0.41246348
114MP0005377_hearing/vestibular/ear_phenot0.40838821
115MP0003878_abnormal_ear_physiology0.40838821
116MP0000470_abnormal_stomach_morphology0.40806552
117MP0003880_abnormal_central_pattern0.40273597
118MP0003699_abnormal_female_reproductive0.38775445
119MP0003329_amyloid_beta_deposits0.38533450
120MP0002269_muscular_atrophy0.36732547
121MP0005360_urolithiasis0.35986111
122MP0001293_anophthalmia0.35211328
123MP0005381_digestive/alimentary_phenotyp0.34257488
124MP0001764_abnormal_homeostasis0.33569437
125MP0002102_abnormal_ear_morphology0.33432049
126MP0001664_abnormal_digestion0.33390887
127MP0001486_abnormal_startle_reflex0.32249312
128MP0004145_abnormal_muscle_electrophysio0.31625593
129MP0004133_heterotaxia0.31265102
130MP0003959_abnormal_lean_body0.31057115
131MP0002092_abnormal_eye_morphology0.29808686
132MP0004811_abnormal_neuron_physiology0.28742358
133MP0001545_abnormal_hematopoietic_system0.28156817
134MP0005397_hematopoietic_system_phenotyp0.28156817
135MP0008995_early_reproductive_senescence0.27947304
136MP0004036_abnormal_muscle_relaxation0.27732127
137MP0002295_abnormal_pulmonary_circulatio0.27648277
138MP0002736_abnormal_nociception_after0.27454147
139MP0003942_abnormal_urinary_system0.26862209
140MP0000604_amyloidosis0.26709583
141MP0009278_abnormal_bone_marrow0.24876820
142MP0008961_abnormal_basal_metabolism0.24685238
143MP0005195_abnormal_posterior_eye0.23820066
144MP0000631_abnormal_neuroendocrine_gland0.23537958
145MP0000579_abnormal_nail_morphology0.23103073
146MP0002139_abnormal_hepatobiliary_system0.23061907
147MP0004742_abnormal_vestibular_system0.22489297
148MP0001119_abnormal_female_reproductive0.22309451
149MP0001849_ear_inflammation0.21447549
150MP0001502_abnormal_circadian_rhythm0.21264254
151MP0000358_abnormal_cell_content/0.20468603
152MP0002735_abnormal_chemical_nociception0.19776779
153MP0000569_abnormal_digit_pigmentation0.18857413
154MP0002152_abnormal_brain_morphology0.18456397
155MP0002752_abnormal_somatic_nervous0.17554277
156MP0003861_abnormal_nervous_system0.16520207
157MP0009115_abnormal_fat_cell0.16406229
158MP0003635_abnormal_synaptic_transmissio0.16342538
159MP0002971_abnormal_brown_adipose0.15729086
160MP0002168_other_aberrant_phenotype0.15342418
161MP0002697_abnormal_eye_size0.14721960
162MP0002114_abnormal_axial_skeleton0.14682859
163MP0002169_no_abnormal_phenotype0.13689183
164MP0001968_abnormal_touch/_nociception0.13577025
165MP0008569_lethality_at_weaning0.13475595
166MP0000001_mammalian_phenotype0.13457744

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.25153322
2Abnormal respiratory motile cilium morphology (HP:0005938)8.90816764
3Abnormal respiratory epithelium morphology (HP:0012253)8.90816764
4Rhinitis (HP:0012384)7.34236457
5Chronic bronchitis (HP:0004469)7.34008443
6Abnormal ciliary motility (HP:0012262)7.18195082
7Infertility (HP:0000789)6.88722552
8Nasal polyposis (HP:0100582)5.90665047
9Small epiphyses (HP:0010585)4.86497750
10Abnormality of the nasal mucosa (HP:0000433)4.82728154
11Polyphagia (HP:0002591)4.57645502
12Chronic hepatic failure (HP:0100626)4.57272220
13Irregular vertebral endplates (HP:0003301)4.36334909
14Bronchitis (HP:0012387)4.32229153
15Bronchiectasis (HP:0002110)4.28310503
16Male infertility (HP:0003251)4.22622451
17Nephronophthisis (HP:0000090)4.02873555
18Abnormality of the vertebral endplates (HP:0005106)3.90626743
19Concave nail (HP:0001598)3.64408564
20Ulnar bowing (HP:0003031)3.59883962
21Abnormal spermatogenesis (HP:0008669)3.58127449
22Radial bowing (HP:0002986)3.35813420
23Abnormality of urine glucose concentration (HP:0011016)3.13378212
24Glycosuria (HP:0003076)3.13378212
25Limited elbow extension (HP:0001377)3.13210317
26Occipital encephalocele (HP:0002085)3.12104028
27Flattened epiphyses (HP:0003071)3.10842120
28Recurrent otitis media (HP:0000403)3.08950515
29Abnormality of the renal medulla (HP:0100957)3.06839639
30Recurrent sinusitis (HP:0011108)3.05136475
31Impulsivity (HP:0100710)3.01871622
32Acute necrotizing encephalopathy (HP:0006965)2.97359261
33Short nail (HP:0001799)2.94319256
34Anosmia (HP:0000458)2.91887335
35Cupped ribs (HP:0000887)2.86382244
36Intestinal atresia (HP:0011100)2.86156215
37True hermaphroditism (HP:0010459)2.81725844
38Flared iliac wings (HP:0002869)2.81665727
39Tubular atrophy (HP:0000092)2.75331836
40Abnormal eating behavior (HP:0100738)2.59286585
41Abnormal mitochondria in muscle tissue (HP:0008316)2.55261586
42Progressive macrocephaly (HP:0004481)2.50425985
43Azoospermia (HP:0000027)2.49574172
44Bowing of the arm (HP:0006488)2.46643702
45Bowed forearm bones (HP:0003956)2.46643702
46Decreased central vision (HP:0007663)2.45132674
47Acute encephalopathy (HP:0006846)2.44450748
48Hypophosphatemic rickets (HP:0004912)2.43163881
49Hypoplasia of the iris (HP:0007676)2.40934150
50Chronic sinusitis (HP:0011109)2.36995154
51Tubulointerstitial nephritis (HP:0001970)2.35311491
523-Methylglutaconic aciduria (HP:0003535)2.32788720
53Esophageal atresia (HP:0002032)2.31315458
54Recurrent bronchitis (HP:0002837)2.31042960
55Hypoplasia of the capital femoral epiphysis (HP:0003090)2.29000853
56Femoral bowing (HP:0002980)2.28982806
57Hypothermia (HP:0002045)2.28956628
58Tubulointerstitial abnormality (HP:0001969)2.28886844
59Median cleft lip (HP:0000161)2.26921601
60Metaphyseal cupping (HP:0003021)2.26503160
61Abnormal drinking behavior (HP:0030082)2.19890204
62Polydipsia (HP:0001959)2.19890204
63Abnormal gallbladder physiology (HP:0012438)2.19262420
64Cholecystitis (HP:0001082)2.19262420
65Rib fusion (HP:0000902)2.15792710
66Coxa vara (HP:0002812)2.15089937
67Pancreatic cysts (HP:0001737)2.14837763
68Dyschromatopsia (HP:0007641)2.11901019
69Abnormality of midbrain morphology (HP:0002418)2.11361267
70Molar tooth sign on MRI (HP:0002419)2.11361267
71Oligodactyly (hands) (HP:0001180)2.10931892
72Hemorrhage of the eye (HP:0011885)2.10907769
73Short ribs (HP:0000773)2.09834559
74Increased corneal curvature (HP:0100692)2.09552097
75Keratoconus (HP:0000563)2.09552097
76Congenital, generalized hypertrichosis (HP:0004540)2.09103027
77Bifid tongue (HP:0010297)2.08236349
78Tubulointerstitial fibrosis (HP:0005576)2.07685772
79Optic disc pallor (HP:0000543)2.06890912
80Anal stenosis (HP:0002025)2.06160544
81Double outlet right ventricle (HP:0001719)2.04386604
82Congenital malformation of the right heart (HP:0011723)2.04386604
83Gastrointestinal atresia (HP:0002589)2.03029180
84Abnormality of the parietal bone (HP:0002696)2.02474686
85Mitochondrial inheritance (HP:0001427)2.02160151
86Osteoarthritis (HP:0002758)2.00098298
87Dynein arm defect of respiratory motile cilia (HP:0012255)13.0691728
88Absent/shortened dynein arms (HP:0200106)13.0691728
89Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.6641594
90Mixed hearing impairment (HP:0000410)1.98331353
91Postaxial foot polydactyly (HP:0001830)1.95070940
92Spastic tetraparesis (HP:0001285)1.94740694
93Growth hormone deficiency (HP:0000824)1.93937765
94Gonadotropin excess (HP:0000837)1.93074594
95Abnormality of the nasal septum (HP:0000419)1.92851675
96Abnormality of renal excretion (HP:0011036)1.91673583
97Choroideremia (HP:0001139)1.90051419
98Partial duplication of the phalanx of hand (HP:0009999)1.89379275
99Anterior segment dysgenesis (HP:0007700)1.87254290
100Abnormality of the phalanges of the 2nd finger (HP:0009541)1.86948092
101Labial hypoplasia (HP:0000066)1.86621549
102Abnormality of dentin (HP:0010299)1.85415842
103Optic nerve coloboma (HP:0000588)1.84341692
104Partial duplication of thumb phalanx (HP:0009944)1.81694332
105Stage 5 chronic kidney disease (HP:0003774)1.81553282
106Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.80937832
107Absent epiphyses (HP:0010577)1.80937832
108Aplasia/Hypoplasia of the tongue (HP:0010295)1.80864867
109Cerebral edema (HP:0002181)1.80837637
110Anencephaly (HP:0002323)1.79741574
111Asymmetric septal hypertrophy (HP:0001670)1.78328828
112Humeroradial synostosis (HP:0003041)1.77951328
113Synostosis involving the elbow (HP:0003938)1.77951328
114Congenital hepatic fibrosis (HP:0002612)1.77599419
115Macrocytic anemia (HP:0001972)1.77240846
116Neurofibrillary tangles (HP:0002185)1.76573033
117Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.75174488
118Erectile abnormalities (HP:0100639)1.73962844
119Sclerocornea (HP:0000647)1.73944665
120Aplasia of the musculature (HP:0100854)1.72848696
121Medial flaring of the eyebrow (HP:0010747)1.72304412
122Disproportionate short-trunk short stature (HP:0003521)1.68454118
123Decreased electroretinogram (ERG) amplitude (HP:0000654)1.65844417
124Abnormality of the renal cortex (HP:0011035)1.65396802
125Loss of speech (HP:0002371)1.64073414
126Renal dysplasia (HP:0000110)1.60750753
127Abnormality of the epiphyses of the hand (HP:0005924)1.60042719
128Abnormality of the dental root (HP:0006486)1.59950368
129Taurodontia (HP:0000679)1.59950368
130Abnormality of permanent molar morphology (HP:0011071)1.59950368
131Abnormal vertebral ossification (HP:0100569)1.59868808
132Facial cleft (HP:0002006)1.59361629
133Abnormal urine output (HP:0012590)1.59207819
134Bile duct proliferation (HP:0001408)1.57529116
135Abnormal biliary tract physiology (HP:0012439)1.57529116
136Abnormality of molar morphology (HP:0011070)1.55066872
137Abnormality of molar (HP:0011077)1.55066872
138Sensory axonal neuropathy (HP:0003390)1.50063240
139Exercise-induced myalgia (HP:0003738)1.49072232
140Abnormality of the dental pulp (HP:0006479)1.49001911
141Hemiparesis (HP:0001269)1.48175618
142J-shaped sella turcica (HP:0002680)1.47471339
143Fibular hypoplasia (HP:0003038)1.43019991
144Vascular calcification (HP:0004934)1.41575478
145Easy fatigability (HP:0003388)1.41174536
146Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.39460587
147Deformed sella turcica (HP:0002681)1.36326728
148Cystic liver disease (HP:0006706)1.36075824
149Bundle branch block (HP:0011710)1.35971791
150Polyuria (HP:0000103)1.35794634
151Aplasia/Hypoplasia of the lens (HP:0008063)1.33803750
152Cerebral inclusion bodies (HP:0100314)1.32541302
153Myoglobinuria (HP:0002913)1.31209457
154Attenuation of retinal blood vessels (HP:0007843)1.30224086
155Bell-shaped thorax (HP:0001591)1.29786361
156Heterotopia (HP:0002282)1.29665695
157Cardiovascular calcification (HP:0011915)1.28990038
158Pancreatic fibrosis (HP:0100732)1.27708352
159Absent eyebrow (HP:0002223)1.25532709
160Retinal dysplasia (HP:0007973)1.24884624
161Short femoral neck (HP:0100864)1.24820000
162Short thorax (HP:0010306)1.24555036
163Hyperkalemia (HP:0002153)1.23848239
164Nephropathy (HP:0000112)1.23600306
165Hypercholesterolemia (HP:0003124)1.21220128
166Upper limb muscle weakness (HP:0003484)1.21127933
167Postaxial hand polydactyly (HP:0001162)1.20444590

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK17.33549972
2PDK37.21071417
3PDK47.21071417
4PRKD35.03693262
5ICK4.89329097
6PDK24.74843859
7TLK13.75227627
8WNK33.40455317
9EPHB22.64470063
10BMPR22.46159973
11STK382.32961827
12STK392.25503481
13WNK42.10462070
14PNCK2.04286638
15PTK2B2.03580700
16FGFR22.02869646
17MAP3K111.88177870
18MAP3K121.87386820
19NLK1.84170575
20NTRK31.80452324
21MAP4K21.77760842
22PHKG11.72959473
23PHKG21.72959473
24FLT31.70548592
25MAP3K21.68539792
26TAF11.67373627
27NME11.67246939
28DYRK1B1.66136897
29SIK21.63328962
30NEK21.61927162
31DYRK21.56681147
32CDK81.53503756
33SIK11.48480737
34EPHA31.35252182
35PDK11.33788608
36CSNK1G11.33560455
37TGFBR11.29061514
38RIPK41.25516825
39STK38L1.23305909
40SIK31.22627363
41EPHA41.20510996
42WEE11.20468022
43MARK31.18449806
44RET1.17064619
45CSNK1G21.12935583
46EPHB11.03299798
47INSRR1.02724381
48LRRK21.00858492
49CAMK1G0.99181850
50BLK0.98083506
51DYRK30.96488555
52TESK20.95876492
53WNK10.95756395
54PDPK10.94810182
55BRSK20.90694935
56CSNK1G30.86896058
57MAP3K70.86536003
58DYRK1A0.84959516
59MAPK150.84434919
60MAP3K100.81029915
61CSNK1A1L0.80373437
62PAK30.78962426
63MARK10.77724070
64MAPK130.76514810
65STK30.75486059
66LATS10.75310512
67PASK0.74776621
68RPS6KB10.74620806
69PINK10.73598916
70SGK4940.69546109
71SGK2230.69546109
72PBK0.68161151
73VRK10.67719163
74TYRO30.66678095
75MUSK0.66100039
76PRKCE0.64690777
77CHEK20.62931590
78AKT30.61325132
79IRAK10.61007916
80GRK10.60995350
81MAP3K30.60858238
82CDK90.60132870
83STK160.56670313
84CAMKK10.56104922
85VRK20.53969765
86OXSR10.53623167
87CSNK1A10.53243365
88KSR20.52386752
89CSNK2A20.49555150
90FGFR10.48727522
91NTRK20.47866080
92PRKCG0.47599860
93MELK0.44250799
94PLK30.43897934
95CDK190.42604275
96TSSK60.42529924
97EEF2K0.42524158
98LATS20.42451567
99PLK20.42126364
100PAK60.42057023
101CCNB10.41528788
102PIK3CA0.41124699
103IRAK20.40046775
104DAPK20.39623181
105STK40.36850712
106TTK0.36416122
107MAP4K10.35200721
108PAK20.31878456
109FER0.31867478
110MAP2K10.31759195
111PAK10.30820666
112PKN20.30679182
113ADRBK10.30595162
114RPS6KA50.30003575
115ZAP700.29540791
116GRK60.29326635
117PRKAA10.28218519
118LMTK20.26357067
119PKN10.26313939
120CDK150.24460341
121ERBB30.20835733
122CDK180.20780213
123EPHA20.20548437
124ATM0.19582644
125FRK0.19320246
126MAP3K40.19003861
127CDK11A0.18074189
128MAP2K70.17977472
129PRKCQ0.17675613
130PRKCZ0.16654211
131CASK0.16616034
132PRKG10.16544601
133CDK140.16430902
134EIF2AK20.15074770
135MAP2K60.14864547
136CHEK10.13836574
137PRKACG0.13446169
138MAPKAPK50.12175687
139ATR0.11564370
140FGR0.11411485
141MARK20.10727517
142CAMK10.08878136
143BRAF0.08500207
144PRKCB0.08190446
145PRKAA20.07596410
146MAP3K10.07080934
147PRKCD0.06434867
148MTOR0.06257130
149CDC42BPA0.05662959
150CSNK2A10.05186902
151RPS6KA10.04983652
152NUAK10.04773999
153PRPF4B0.04506866
154PRKCA0.03742841
155PIM10.03441909
156CAMK2A0.03302555
157DDR20.02839435
158CDK30.02381286
159OBSCN0.02152551
160CSF1R0.01757308
161PRKACA0.01263658
162CDK60.00924745
163MAP3K50.00746471
164MAP2K4-0.0282655
165CAMK1D-0.0248827
166PAK4-0.0225417
167PLK1-0.0220137
168STK11-0.0164062
169GSK3B-0.0109981
170NEK6-0.0092470

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.90096134
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.45471967
3Ribosome_Homo sapiens_hsa030104.38646404
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.13996997
5Oxidative phosphorylation_Homo sapiens_hsa001904.02946641
6Vitamin B6 metabolism_Homo sapiens_hsa007503.63707660
7Parkinsons disease_Homo sapiens_hsa050123.19133190
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.08135848
9Pyruvate metabolism_Homo sapiens_hsa006203.03803169
10Linoleic acid metabolism_Homo sapiens_hsa005912.96672037
11Propanoate metabolism_Homo sapiens_hsa006402.75208929
12Alzheimers disease_Homo sapiens_hsa050102.61544146
13Glucagon signaling pathway_Homo sapiens_hsa049222.54219136
14Protein export_Homo sapiens_hsa030602.52813627
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.41642706
16Proteasome_Homo sapiens_hsa030502.33033240
17Nitrogen metabolism_Homo sapiens_hsa009102.19418372
18Carbohydrate digestion and absorption_Homo sapiens_hsa049732.17242257
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.16630514
20Glycerolipid metabolism_Homo sapiens_hsa005612.10986785
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.05571836
22PPAR signaling pathway_Homo sapiens_hsa033201.97380948
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.87899540
24Basal cell carcinoma_Homo sapiens_hsa052171.84921907
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.80574399
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.78120348
27Amphetamine addiction_Homo sapiens_hsa050311.72470029
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.68761357
29Mineral absorption_Homo sapiens_hsa049781.64137747
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62936942
31Glycerophospholipid metabolism_Homo sapiens_hsa005641.62576182
32Fat digestion and absorption_Homo sapiens_hsa049751.56480687
33Butanoate metabolism_Homo sapiens_hsa006501.54940000
34Ether lipid metabolism_Homo sapiens_hsa005651.53717596
35Fatty acid degradation_Homo sapiens_hsa000711.53612731
36Fatty acid metabolism_Homo sapiens_hsa012121.52806087
37Selenocompound metabolism_Homo sapiens_hsa004501.48204449
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.47823550
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.46382833
40Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.44657807
41Folate biosynthesis_Homo sapiens_hsa007901.43830425
42Fructose and mannose metabolism_Homo sapiens_hsa000511.41057259
43RNA polymerase_Homo sapiens_hsa030201.38811134
44Collecting duct acid secretion_Homo sapiens_hsa049661.37913921
45Basal transcription factors_Homo sapiens_hsa030221.33712942
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.33523406
47Dorso-ventral axis formation_Homo sapiens_hsa043201.32971307
48Steroid biosynthesis_Homo sapiens_hsa001001.28245438
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24798941
50Oocyte meiosis_Homo sapiens_hsa041141.22857195
51Cardiac muscle contraction_Homo sapiens_hsa042601.22856575
52Pentose phosphate pathway_Homo sapiens_hsa000301.22013290
53Renin secretion_Homo sapiens_hsa049241.16405953
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.15821314
55Circadian rhythm_Homo sapiens_hsa047101.14858292
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13892518
57Taste transduction_Homo sapiens_hsa047421.13710105
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.11909615
59Carbon metabolism_Homo sapiens_hsa012001.07879443
60Glutathione metabolism_Homo sapiens_hsa004801.07184126
61Ovarian steroidogenesis_Homo sapiens_hsa049131.06220887
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05530049
63Arginine biosynthesis_Homo sapiens_hsa002200.99538260
64TGF-beta signaling pathway_Homo sapiens_hsa043500.99050164
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.98469756
66Fanconi anemia pathway_Homo sapiens_hsa034600.96209406
67Serotonergic synapse_Homo sapiens_hsa047260.94317807
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91329319
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91286072
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.89875476
71GABAergic synapse_Homo sapiens_hsa047270.89397968
72ABC transporters_Homo sapiens_hsa020100.88407933
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85867392
74Hedgehog signaling pathway_Homo sapiens_hsa043400.84423652
75Insulin secretion_Homo sapiens_hsa049110.84365919
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84006657
77Sulfur metabolism_Homo sapiens_hsa009200.83471413
78Chemical carcinogenesis_Homo sapiens_hsa052040.83059284
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80328694
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79661480
81Synaptic vesicle cycle_Homo sapiens_hsa047210.79277602
82Galactose metabolism_Homo sapiens_hsa000520.78105583
83Purine metabolism_Homo sapiens_hsa002300.76894383
84Nicotine addiction_Homo sapiens_hsa050330.74615702
85Long-term potentiation_Homo sapiens_hsa047200.73582838
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.71789091
87Arachidonic acid metabolism_Homo sapiens_hsa005900.71479555
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71240681
89Renin-angiotensin system_Homo sapiens_hsa046140.69491064
90Calcium signaling pathway_Homo sapiens_hsa040200.68259830
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68150593
92Salivary secretion_Homo sapiens_hsa049700.67384478
93Antigen processing and presentation_Homo sapiens_hsa046120.64374547
94Peroxisome_Homo sapiens_hsa041460.62423887
95cAMP signaling pathway_Homo sapiens_hsa040240.62359825
96Thyroid hormone synthesis_Homo sapiens_hsa049180.61983092
97Systemic lupus erythematosus_Homo sapiens_hsa053220.61861586
98Pancreatic secretion_Homo sapiens_hsa049720.61071883
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59822554
100Huntingtons disease_Homo sapiens_hsa050160.58719738
101Melanogenesis_Homo sapiens_hsa049160.58158938
102Bile secretion_Homo sapiens_hsa049760.57700865
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57385122
104Caffeine metabolism_Homo sapiens_hsa002320.54897428
105Estrogen signaling pathway_Homo sapiens_hsa049150.53224990
106Vitamin digestion and absorption_Homo sapiens_hsa049770.52936422
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51480589
108Protein digestion and absorption_Homo sapiens_hsa049740.51330099
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.49238400
110Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48950440
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48168518
112Primary bile acid biosynthesis_Homo sapiens_hsa001200.45762371
113Gap junction_Homo sapiens_hsa045400.45658179
114Biosynthesis of amino acids_Homo sapiens_hsa012300.44786063
115Phototransduction_Homo sapiens_hsa047440.44775378
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44415550
117Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43213395
118AMPK signaling pathway_Homo sapiens_hsa041520.43135814
119Axon guidance_Homo sapiens_hsa043600.42951999
120Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42788243
121Alcoholism_Homo sapiens_hsa050340.42647858
122Wnt signaling pathway_Homo sapiens_hsa043100.42472031
123Endocytosis_Homo sapiens_hsa041440.41569253
124Olfactory transduction_Homo sapiens_hsa047400.37930841
125Hippo signaling pathway_Homo sapiens_hsa043900.37672779
126Retinol metabolism_Homo sapiens_hsa008300.36325969
127Histidine metabolism_Homo sapiens_hsa003400.36274115
128Morphine addiction_Homo sapiens_hsa050320.35851930
129Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35496158
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35290007
131Inositol phosphate metabolism_Homo sapiens_hsa005620.35213556
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35031319
133RNA degradation_Homo sapiens_hsa030180.34858550
134Starch and sucrose metabolism_Homo sapiens_hsa005000.34605145
135Steroid hormone biosynthesis_Homo sapiens_hsa001400.33721894
136Tyrosine metabolism_Homo sapiens_hsa003500.33711148
137Gastric acid secretion_Homo sapiens_hsa049710.33440014
138Metabolic pathways_Homo sapiens_hsa011000.33001177
139Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32656877
140Cocaine addiction_Homo sapiens_hsa050300.31515333
141ECM-receptor interaction_Homo sapiens_hsa045120.31324970
142Phenylalanine metabolism_Homo sapiens_hsa003600.30261113
143Other glycan degradation_Homo sapiens_hsa005110.29367966
144Circadian entrainment_Homo sapiens_hsa047130.29000550
145Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28815007
146Arginine and proline metabolism_Homo sapiens_hsa003300.27163643
147Legionellosis_Homo sapiens_hsa051340.27045370
148VEGF signaling pathway_Homo sapiens_hsa043700.27043304
149Glutamatergic synapse_Homo sapiens_hsa047240.25990058
150Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24249980
151Prion diseases_Homo sapiens_hsa050200.24158689
152Fatty acid elongation_Homo sapiens_hsa000620.23562479
153B cell receptor signaling pathway_Homo sapiens_hsa046620.22440920
154Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22381821

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