CIC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of histone deacetylation (GO:0031065)3.78388368
2regulation of NFAT protein import into nucleus (GO:0051532)3.72894433
3cytoskeletal anchoring at plasma membrane (GO:0007016)3.70965855
4layer formation in cerebral cortex (GO:0021819)3.46183274
5sodium ion export (GO:0071436)3.42910131
6pre-miRNA processing (GO:0031054)3.31410748
7synaptic vesicle maturation (GO:0016188)3.22706284
8locomotory exploration behavior (GO:0035641)3.21754022
9positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.21398865
10negative regulation of cell size (GO:0045792)3.16987382
11regulation of ARF GTPase activity (GO:0032312)3.16576740
12cytoplasmic mRNA processing body assembly (GO:0033962)3.10376578
13regulation of ARF protein signal transduction (GO:0032012)3.06508456
14peptidyl-lysine dimethylation (GO:0018027)3.04353937
15negative regulation of cell killing (GO:0031342)2.95978862
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.95978862
17positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.94465402
18intracellular estrogen receptor signaling pathway (GO:0030520)2.88287923
19cell-cell junction maintenance (GO:0045217)2.86790850
20response to muramyl dipeptide (GO:0032495)2.83895351
21glucocorticoid receptor signaling pathway (GO:0042921)2.83256956
22stress fiber assembly (GO:0043149)2.83063730
23regulation of extracellular matrix disassembly (GO:0010715)2.82779783
24NLS-bearing protein import into nucleus (GO:0006607)2.80331005
25activation of Rac GTPase activity (GO:0032863)2.79067366
26insulin-like growth factor receptor signaling pathway (GO:0048009)2.77432454
27positive regulation of fibroblast migration (GO:0010763)2.76831236
28protein localization to endosome (GO:0036010)2.75000299
29endothelial cell chemotaxis (GO:0035767)2.73443559
30adherens junction assembly (GO:0034333)2.71269637
31establishment of nucleus localization (GO:0040023)2.69081108
32negative regulation of fatty acid transport (GO:2000192)2.66715269
33positive regulation of gene expression, epigenetic (GO:0045815)2.63178036
34positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.62048492
35positive regulation of receptor recycling (GO:0001921)2.61100948
36regulation of clathrin-mediated endocytosis (GO:2000369)2.61032895
37peptidyl-tyrosine autophosphorylation (GO:0038083)2.60393884
38atrioventricular valve morphogenesis (GO:0003181)2.58796474
39activation of JUN kinase activity (GO:0007257)2.55890501
40barbed-end actin filament capping (GO:0051016)2.55829103
41negative regulation of erythrocyte differentiation (GO:0045647)2.55239280
42positive regulation of CREB transcription factor activity (GO:0032793)2.54400301
43cortical actin cytoskeleton organization (GO:0030866)2.53456309
44cerebellar granule cell differentiation (GO:0021707)2.51880136
45regulation of histone H3-K27 methylation (GO:0061085)2.50381835
46positive regulation of protein deacetylation (GO:0090312)2.50106517
47regulation of glucose import in response to insulin stimulus (GO:2001273)2.50038002
48negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.49532029
49receptor catabolic process (GO:0032801)2.49496056
50negative regulation of myotube differentiation (GO:0010832)2.49026842
51positive regulation of blood vessel endothelial cell migration (GO:0043536)2.48689114
52plasma membrane repair (GO:0001778)2.47081917
53clathrin coat assembly (GO:0048268)2.46542475
54positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.45865425
55antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.44694568
56protein targeting to plasma membrane (GO:0072661)2.44477276
57activation of MAPKKK activity (GO:0000185)2.43669305
58germ cell migration (GO:0008354)2.41897637
59regulation of T-helper 2 cell differentiation (GO:0045628)2.41223679
60glial cell proliferation (GO:0014009)2.40678943
61modulation by symbiont of host cellular process (GO:0044068)2.39536219
62G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.38321104
63cell migration in hindbrain (GO:0021535)2.38312720
64heterochromatin organization (GO:0070828)2.36633788
65embryonic process involved in female pregnancy (GO:0060136)2.36336600
66regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.35787521
67regulation of early endosome to late endosome transport (GO:2000641)2.35780144
68regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.35738979
69stress granule assembly (GO:0034063)2.35272520
70semaphorin-plexin signaling pathway (GO:0071526)2.34841888
71modulation by virus of host process (GO:0019054)2.34781412
72focal adhesion assembly (GO:0048041)2.34774801
73cell-substrate adherens junction assembly (GO:0007045)2.34774801
74positive regulation of protein dephosphorylation (GO:0035307)2.34342316
75positive thymic T cell selection (GO:0045059)2.33443647
76apoptotic cell clearance (GO:0043277)2.32902753
77vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.32436738
78peptidyl-threonine phosphorylation (GO:0018107)2.32419034
79regulation of gamma-delta T cell differentiation (GO:0045586)2.31609164
80signal complex assembly (GO:0007172)2.30945714
81positive regulation of Rap GTPase activity (GO:0032854)2.30928810
82negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.30472802
83corticosteroid receptor signaling pathway (GO:0031958)2.30377779
84regulation of short-term neuronal synaptic plasticity (GO:0048172)2.30199556
85planar cell polarity pathway involved in neural tube closure (GO:0090179)2.29995867
86antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.29676687
87synaptic vesicle docking involved in exocytosis (GO:0016081)2.29627322
88cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.29230727
89negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.28887038
90positive regulation of synapse maturation (GO:0090129)2.27179053
91cell-substrate junction assembly (GO:0007044)2.26351261
92regulation of histone deacetylation (GO:0031063)2.26074956
93response to laminar fluid shear stress (GO:0034616)2.25830392
94germinal center formation (GO:0002467)2.25383879
95negative regulation of histone methylation (GO:0031061)2.25098743
96histone H4 deacetylation (GO:0070933)2.24815464
97peptidyl-threonine modification (GO:0018210)2.24543673
983-UTR-mediated mRNA stabilization (GO:0070935)2.23877959
99basement membrane organization (GO:0071711)2.23587155
100mRNA stabilization (GO:0048255)2.21852759
101RNA stabilization (GO:0043489)2.21852759
102negative regulation of nucleotide catabolic process (GO:0030812)2.21778273
103cell volume homeostasis (GO:0006884)2.21754876
104antigen processing and presentation of endogenous antigen (GO:0019883)2.21502923
105modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.21349000
106modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.21349000
107positive regulation by organism of defense response of other organism involved in symbiotic interact2.21349000
108modulation by symbiont of host immune response (GO:0052553)2.21349000
109positive regulation by symbiont of host defense response (GO:0052509)2.21349000
110modulation by symbiont of host defense response (GO:0052031)2.21349000
111thymic T cell selection (GO:0045061)2.20287668
112activation of protein kinase A activity (GO:0034199)2.20243314
113protein retention in ER lumen (GO:0006621)2.19366156
114histone H3-K4 methylation (GO:0051568)2.18211731
115positive regulation of Cdc42 GTPase activity (GO:0043089)2.17636844
116natural killer cell differentiation (GO:0001779)2.17147542
117T cell selection (GO:0045058)2.16966640
118regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.16644125
119regulation of lipid kinase activity (GO:0043550)2.16547237
120histone H3-K9 demethylation (GO:0033169)2.16516259
121regulation of chromatin binding (GO:0035561)2.15615553
122regulation of hippo signaling (GO:0035330)2.15205251
123neuromuscular process controlling balance (GO:0050885)2.15195569
124cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.13813697
125histone H3-K36 demethylation (GO:0070544)2.13182451
126hemidesmosome assembly (GO:0031581)2.13175295
127apoptotic process involved in morphogenesis (GO:0060561)2.12792075
128regulation of phosphatidylinositol 3-kinase activity (GO:0043551)2.12542203
129regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.12254592
130regulation of protein deacetylation (GO:0090311)2.11637411
131epithelial cell differentiation involved in prostate gland development (GO:0060742)2.11631842
132negative regulation of Ras protein signal transduction (GO:0046580)2.10988265
133negative regulation of catenin import into nucleus (GO:0035414)2.10948698
134negative regulation of glial cell proliferation (GO:0060253)2.10861497
135cell communication by electrical coupling (GO:0010644)2.09484232
136maternal placenta development (GO:0001893)2.09397841
137negative regulation of toll-like receptor signaling pathway (GO:0034122)2.09224368
138platelet formation (GO:0030220)2.08691789
139regulation of leukocyte degranulation (GO:0043300)2.08299013
140regulation of gamma-delta T cell activation (GO:0046643)2.08230769
141cell junction maintenance (GO:0034331)2.08136042
142establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.07890581
143regulation of synapse structural plasticity (GO:0051823)2.07818078
144polarized epithelial cell differentiation (GO:0030859)2.07232083
145positive regulation of RNA splicing (GO:0033120)2.06513165
146mannose metabolic process (GO:0006013)2.05552446
147histone H4-K16 acetylation (GO:0043984)2.04873196
148positive regulation of axon extension (GO:0045773)2.04853009
149positive regulation of gamma-delta T cell activation (GO:0046645)2.04669037
150proline transport (GO:0015824)2.04106321
151response to fluid shear stress (GO:0034405)2.04089854
152cortical cytoskeleton organization (GO:0030865)2.03410937
153protein heterotrimerization (GO:0070208)2.02917678
154regulation of Rap GTPase activity (GO:0032317)2.02038084
155positive regulation of SMAD protein import into nucleus (GO:0060391)2.01676876
156hippo signaling (GO:0035329)2.01092169

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.54208862
2MYC_22102868_ChIP-Seq_BL_Human3.39082915
3KDM2B_26808549_Chip-Seq_SUP-B15_Human3.06015751
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.99009037
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.97050933
6* KDM2B_26808549_Chip-Seq_DND41_Human2.95137721
7* TCF7_22412390_ChIP-Seq_EML_Mouse2.67962647
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.65726086
9* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.50548329
10* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.47470796
11ZFP281_18757296_ChIP-ChIP_E14_Mouse2.41091568
12KDM2B_26808549_Chip-Seq_K562_Human2.39850079
13VDR_21846776_ChIP-Seq_THP-1_Human2.39141115
14* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.18453065
15* LXR_22292898_ChIP-Seq_THP-1_Human2.18324266
16* KDM2B_26808549_Chip-Seq_JURKAT_Human2.17444227
17* ELK3_25401928_ChIP-Seq_HUVEC_Human2.14656486
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.06635177
19* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.04927817
20* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.93585541
21* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.87117518
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.83760781
23* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.79063636
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.77897003
25P300_27058665_Chip-Seq_ZR-75-30cells_Human1.76508730
26* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.74254937
27ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.72717050
28GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.69973143
29FOXM1_23109430_ChIP-Seq_U2OS_Human1.68694789
30TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.68144351
31DROSHA_22980978_ChIP-Seq_HELA_Human1.65093059
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.64617574
33RACK7_27058665_Chip-Seq_MCF-7_Human1.64355529
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59221461
35* RARB_27405468_Chip-Seq_BRAIN_Mouse1.59058662
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58416744
37UTX_26944678_Chip-Seq_JUKART_Human1.55019926
38* MAF_26560356_Chip-Seq_TH1_Human1.53915991
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.49354771
40SPI1_23127762_ChIP-Seq_K562_Human1.49232435
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49204949
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48094921
43* CREB1_26743006_Chip-Seq_LNCaP_Human1.44001558
44ZNF263_19887448_ChIP-Seq_K562_Human1.43716105
45* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.41599675
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.40616669
47VDR_24763502_ChIP-Seq_THP-1_Human1.40053395
48* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.39648670
49* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37507920
50UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.31143419
51CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.30757507
52GATA1_19941826_ChIP-Seq_K562_Human1.30708187
53SCL_19346495_ChIP-Seq_HPC-7_Human1.30464031
54NCOR1_26117541_ChIP-Seq_K562_Human1.28427331
55SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.28422811
56SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28375605
57* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27488231
58TET1_21451524_ChIP-Seq_MESCs_Mouse1.27254312
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23126816
60TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.22898400
61* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22169046
62CTCF_27219007_Chip-Seq_Bcells_Human1.21524199
63RUNX1_27514584_Chip-Seq_MCF-7_Human1.19050886
64GATA1_19941827_ChIP-Seq_MEL_Mouse1.18452741
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.17713276
66TP63_17297297_ChIP-ChIP_HaCaT_Human1.16857789
67TP53_22127205_ChIP-Seq_IMR90_Human1.16603581
68* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13494783
69WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13336469
70* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13005591
71P68_20966046_ChIP-Seq_HELA_Human1.12721548
72NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12202084
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10474941
74SMC4_20622854_ChIP-Seq_HELA_Human1.10002908
75* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.09053527
76* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07841677
77* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07618322
78* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07438107
79ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06331648
80* ATF3_27146783_Chip-Seq_COLON_Human1.06136217
81SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05388656
82ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.04971886
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04850740
84* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04531608
85RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04305165
86FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.04000644
87SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03668726
88RUNX_20019798_ChIP-Seq_JUKART_Human1.02936032
89ERG_21242973_ChIP-ChIP_JURKAT_Human1.01125873
90* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00303147
91MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.99927145
92BCOR_27268052_Chip-Seq_Bcells_Human0.99527592
93TET1_21490601_ChIP-Seq_MESCs_Mouse0.98412121
94SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98150155
95NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98069726
96* SA1_27219007_Chip-Seq_ERYTHROID_Human0.97563887
97PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97107519
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96029685
99* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95812771
100PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.95629342
101* MAF_26560356_Chip-Seq_TH2_Human0.95284900
102RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95047309
103* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94928817
104TBX20_22080862_ChIP-Seq_HEART_Mouse0.94641804
105TBX20_22328084_ChIP-Seq_HEART_Mouse0.94641804
106NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94234361
107* TP53_23651856_ChIP-Seq_MEFs_Mouse0.93931517
108UBF1/2_26484160_Chip-Seq_HMECs_Human0.93412282
109ISL1_27105846_Chip-Seq_CPCs_Mouse0.93013993
110ELF1_20517297_ChIP-Seq_JURKAT_Human0.91895832
111* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91809612
112GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91575396
113FOXO3_23340844_ChIP-Seq_DLD1_Human0.90870252
114MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.90324789
115ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.90097547
116RUNX1_22412390_ChIP-Seq_EML_Mouse0.89730524
117OCT4_19829295_ChIP-Seq_ESCs_Human0.87420329
118CLOCK_20551151_ChIP-Seq_293T_Human0.86290309
119GATA2_19941826_ChIP-Seq_K562_Human0.85097092
120CTCF_21964334_ChIP-Seq_BJAB-B_Human0.84634342
121TP63_22573176_ChIP-Seq_HFKS_Human0.83248188
122* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.82906384

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.15837904
2MP0004859_abnormal_synaptic_plasticity3.29657643
3MP0005076_abnormal_cell_differentiation3.27703365
4MP0009278_abnormal_bone_marrow3.00121812
5MP0003303_peritoneal_inflammation2.89265997
6MP0003300_gastrointestinal_ulcer2.81860994
7MP0005409_darkened_coat_color2.74905921
8MP0000569_abnormal_digit_pigmentation2.72109576
9MP0010352_gastrointestinal_tract_polyps2.56028310
10MP0004858_abnormal_nervous_system2.50634253
11MP0008961_abnormal_basal_metabolism2.47251951
12MP0003436_decreased_susceptibility_to2.34743330
13MP0008260_abnormal_autophagy2.20127860
14MP0005058_abnormal_lysosome_morphology2.11290110
15MP0001849_ear_inflammation2.06013914
16MP0002249_abnormal_larynx_morphology2.04979317
17MP0004510_myositis2.00078071
18MP0005623_abnormal_meninges_morphology1.96481913
19MP0003566_abnormal_cell_adhesion1.78800208
20MP0000733_abnormal_muscle_development1.78018610
21MP0005451_abnormal_body_composition1.71463276
22MP0003045_fibrosis1.71364160
23MP0003172_abnormal_lysosome_physiology1.70796320
24MP0003283_abnormal_digestive_organ1.70135141
25MP0009780_abnormal_chondrocyte_physiolo1.68429832
26MP0003453_abnormal_keratinocyte_physiol1.66718254
27MP0004381_abnormal_hair_follicle1.55405645
28MP0000678_abnormal_parathyroid_gland1.54322686
29MP0003091_abnormal_cell_migration1.54053089
30MP0002653_abnormal_ependyma_morphology1.53781985
31MP0004233_abnormal_muscle_weight1.45994106
32MP0001545_abnormal_hematopoietic_system1.44233214
33MP0005397_hematopoietic_system_phenotyp1.44233214
34MP0001348_abnormal_lacrimal_gland1.42647518
35MP0003191_abnormal_cellular_cholesterol1.41198083
36MP0004808_abnormal_hematopoietic_stem1.40047098
37MP0002998_abnormal_bone_remodeling1.35835399
38MP0010307_abnormal_tumor_latency1.34716028
39MP0005275_abnormal_skin_tensile1.31260431
40MP0009840_abnormal_foam_cell1.30605617
41MP0010234_abnormal_vibrissa_follicle1.30587226
42MP0002877_abnormal_melanocyte_morpholog1.29280021
43MP0003763_abnormal_thymus_physiology1.28888447
44MP0004185_abnormal_adipocyte_glucose1.28128773
45MP0008438_abnormal_cutaneous_collagen1.23648311
46MP0003787_abnormal_imprinting1.22805196
47MP0003279_aneurysm1.19073566
48MP0003115_abnormal_respiratory_system1.18086597
49MP0002909_abnormal_adrenal_gland1.17189860
50MP0010630_abnormal_cardiac_muscle1.15210554
51MP0002925_abnormal_cardiovascular_devel1.14119594
52MP0000751_myopathy1.13982340
53MP0000428_abnormal_craniofacial_morphol1.13332575
54MP0000003_abnormal_adipose_tissue1.12200356
55MP0003635_abnormal_synaptic_transmissio1.11153342
56MP0002933_joint_inflammation1.10534981
57MP0004197_abnormal_fetal_growth/weight/1.10199755
58MP0002089_abnormal_postnatal_growth/wei1.10132028
59MP0004885_abnormal_endolymph1.09870281
60MP0002396_abnormal_hematopoietic_system1.08573193
61MP0003690_abnormal_glial_cell1.08504845
62MP0005670_abnormal_white_adipose1.08388603
63MP0008770_decreased_survivor_rate1.07487047
64MP0004087_abnormal_muscle_fiber1.07461706
65MP0001533_abnormal_skeleton_physiology1.07401210
66MP0004811_abnormal_neuron_physiology1.06699720
67MP0008569_lethality_at_weaning1.05863538
68MP0002060_abnormal_skin_morphology1.05720628
69MP0001958_emphysema1.03452572
70MP0003828_pulmonary_edema1.02918503
71MP0000534_abnormal_ureter_morphology1.01930856
72MP0004130_abnormal_muscle_cell1.00850160
73MP0005503_abnormal_tendon_morphology1.00755477
74MP0000858_altered_metastatic_potential0.98764420
75MP0001915_intracranial_hemorrhage0.98191750
76MP0003634_abnormal_glial_cell0.97054272
77MP0005023_abnormal_wound_healing0.96366923
78MP0002419_abnormal_innate_immunity0.95865186
79MP0005375_adipose_tissue_phenotype0.95500859
80MP0002084_abnormal_developmental_patter0.94986697
81MP0002796_impaired_skin_barrier0.94280055
82MP0000703_abnormal_thymus_morphology0.92299637
83MP0005390_skeleton_phenotype0.91078833
84MP0002086_abnormal_extraembryonic_tissu0.90276535
85MP0000266_abnormal_heart_morphology0.89898404
86MP0001851_eye_inflammation0.89886212
87MP0004947_skin_inflammation0.87544235
88MP0005025_abnormal_response_to0.86121198
89MP0001790_abnormal_immune_system0.85317916
90MP0005387_immune_system_phenotype0.85317916
91MP0005000_abnormal_immune_tolerance0.85244109
92MP0005257_abnormal_intraocular_pressure0.85064130
93MP0000685_abnormal_immune_system0.84592945
94MP0006138_congestive_heart_failure0.84293172
95MP0000537_abnormal_urethra_morphology0.83898496
96MP0003183_abnormal_peptide_metabolism0.83266095
97MP0003329_amyloid_beta_deposits0.83044726
98MP0000604_amyloidosis0.82019213
99MP0003879_abnormal_hair_cell0.81813572
100MP0003935_abnormal_craniofacial_develop0.81397019
101MP0009333_abnormal_splenocyte_physiolog0.80857801
102MP0000767_abnormal_smooth_muscle0.80621089
103MP0003075_altered_response_to0.80510696
104MP0003984_embryonic_growth_retardation0.79773960
105MP0002088_abnormal_embryonic_growth/wei0.79772501
106MP0002085_abnormal_embryonic_tissue0.78908031
107MP0005508_abnormal_skeleton_morphology0.78547739
108MP0000747_muscle_weakness0.78061920
109MP0001784_abnormal_fluid_regulation0.77319879
110MP0002063_abnormal_learning/memory/cond0.76901896
111MP0003119_abnormal_digestive_system0.76895902
112MP0001502_abnormal_circadian_rhythm0.76880913
113MP0005423_abnormal_somatic_nervous0.76411219
114MP0009703_decreased_birth_body0.76330740
115MP0003861_abnormal_nervous_system0.76327386
116MP0009931_abnormal_skin_appearance0.75580013
117MP0004272_abnormal_basement_membrane0.74900042
118MP0002398_abnormal_bone_marrow0.74456207
119MP0009384_cardiac_valve_regurgitation0.73558614
120MP0001730_embryonic_growth_arrest0.73420522
121MP0000350_abnormal_cell_proliferation0.73048648
122MP0000681_abnormal_thyroid_gland0.72212244
123MP0000955_abnormal_spinal_cord0.71866721
124MP0009672_abnormal_birth_weight0.71445837
125MP0008874_decreased_physiological_sensi0.71076204
126MP0006054_spinal_hemorrhage0.70907687
127MP0000759_abnormal_skeletal_muscle0.70869617
128MP0001800_abnormal_humoral_immune0.70459491
129MP0001672_abnormal_embryogenesis/_devel0.70312004
130MP0005380_embryogenesis_phenotype0.70312004
131MP0004084_abnormal_cardiac_muscle0.70292265
132MP0000920_abnormal_myelination0.70170199
133MP0002420_abnormal_adaptive_immunity0.69747471
134MP0005666_abnormal_adipose_tissue0.69333044
135MP0003385_abnormal_body_wall0.69196621
136MP0001819_abnormal_immune_cell0.68523404
137MP0010155_abnormal_intestine_physiology0.68367771
138MP0005248_abnormal_Harderian_gland0.68246525
139MP0003866_abnormal_defecation0.67895863
140MP0003448_altered_tumor_morphology0.67737680
141MP0001697_abnormal_embryo_size0.66035089
142MP0002234_abnormal_pharynx_morphology0.65296630
143MP0002896_abnormal_bone_mineralization0.65168963
144MP0002152_abnormal_brain_morphology0.64375879
145MP0005187_abnormal_penis_morphology0.63810955
146MP0005621_abnormal_cell_physiology0.62937846
147MP0001614_abnormal_blood_vessel0.62710788
148MP0010030_abnormal_orbit_morphology0.62213056
149MP0001299_abnormal_eye_distance/0.62071377
150MP0002128_abnormal_blood_circulation0.61548713

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.75317593
2Cerebral aneurysm (HP:0004944)3.58620552
3Shallow orbits (HP:0000586)3.41289284
4Broad face (HP:0000283)3.40994579
5Macroorchidism (HP:0000053)2.82558382
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.77687100
7Short 4th metacarpal (HP:0010044)2.77687100
8Insomnia (HP:0100785)2.77663236
9Distal upper limb amyotrophy (HP:0007149)2.68398482
10Upper limb amyotrophy (HP:0009129)2.68398482
11Abnormality of the lower motor neuron (HP:0002366)2.68345642
12Elfin facies (HP:0004428)2.62170770
13Hand muscle atrophy (HP:0009130)2.59993817
14Renal duplication (HP:0000075)2.47364778
15Renovascular hypertension (HP:0100817)2.45440680
16Distal lower limb amyotrophy (HP:0008944)2.45053801
17Protrusio acetabuli (HP:0003179)2.41252605
18Abnormality of the fingertips (HP:0001211)2.41146137
19Pointed chin (HP:0000307)2.39284504
20Genu recurvatum (HP:0002816)2.34397209
21Cervical subluxation (HP:0003308)2.32718611
22Bladder diverticulum (HP:0000015)2.31495600
23Bowel diverticulosis (HP:0005222)2.30142044
24Mitral valve prolapse (HP:0001634)2.29677908
25Increased variability in muscle fiber diameter (HP:0003557)2.25607437
26Overriding aorta (HP:0002623)2.24154954
27Mitral regurgitation (HP:0001653)2.21963802
28Eczematoid dermatitis (HP:0000976)2.19432357
29Ankle contracture (HP:0006466)2.19029122
30Enlarged penis (HP:0000040)2.17275988
31Broad metatarsal (HP:0001783)2.16249219
32Abnormality of the 4th metacarpal (HP:0010012)2.15445264
33Neoplasm of the heart (HP:0100544)2.12594401
34Abnormality of the astrocytes (HP:0100707)2.11451418
35Astrocytoma (HP:0009592)2.11451418
36Increased density of long bones (HP:0006392)2.10926698
37Dysmetric saccades (HP:0000641)2.10395034
38Neurofibrillary tangles (HP:0002185)2.08833762
39Dislocated radial head (HP:0003083)2.07757593
40Fragile skin (HP:0001030)2.06680563
41Dilatation of the ascending aorta (HP:0005111)2.06652880
42Heterotopia (HP:0002282)2.05303695
43Narrow palate (HP:0000189)2.02689171
44Annular pancreas (HP:0001734)2.02347045
45Cerebral inclusion bodies (HP:0100314)2.00058107
46Ulnar bowing (HP:0003031)1.99543444
47Broad palm (HP:0001169)1.99112059
48Supranuclear gaze palsy (HP:0000605)1.97815451
49Bronchomalacia (HP:0002780)1.97590513
50Abnormality of the radial head (HP:0003995)1.97384421
51Aortic aneurysm (HP:0004942)1.97096774
52Aneurysm (HP:0002617)1.96749169
53Increased IgE level (HP:0003212)1.96591156
54Flat cornea (HP:0007720)1.95240192
55Disproportionate tall stature (HP:0001519)1.95065994
56Genetic anticipation (HP:0003743)1.94074948
57Lymphangioma (HP:0100764)1.92632594
58Trigonocephaly (HP:0000243)1.92630029
59Abnormality of skeletal muscle fiber size (HP:0012084)1.90743783
60Hemorrhage of the eye (HP:0011885)1.89245413
61Urethral obstruction (HP:0000796)1.88938747
62Increased nuchal translucency (HP:0010880)1.88259774
63Deviation of the hallux (HP:0010051)1.87508192
64Hallux valgus (HP:0001822)1.87281212
65Arterial tortuosity (HP:0005116)1.86597641
66Obstructive sleep apnea (HP:0002870)1.86212122
67Mildly elevated creatine phosphokinase (HP:0008180)1.84417394
68Subacute progressive viral hepatitis (HP:0006572)1.84148675
69Segmental peripheral demyelination/remyelination (HP:0003481)1.83258253
70Long eyelashes (HP:0000527)1.83138826
71Stridor (HP:0010307)1.83067978
72Abnormality of the distal phalanx of the thumb (HP:0009617)1.82439671
73Apathy (HP:0000741)1.82296224
74Difficulty climbing stairs (HP:0003551)1.82285775
75Onion bulb formation (HP:0003383)1.81358465
76Vascular tortuosity (HP:0004948)1.81310463
77Emphysema (HP:0002097)1.80397613
78Ankyloglossia (HP:0010296)1.80390957
79Lower limb amyotrophy (HP:0007210)1.79927399
80Hemiplegia (HP:0002301)1.79680780
81Spinal rigidity (HP:0003306)1.79492853
82Wormian bones (HP:0002645)1.78195997
83Biconcave vertebral bodies (HP:0004586)1.77718947
84Flat acetabular roof (HP:0003180)1.77592921
85Easy fatigability (HP:0003388)1.76683631
86Blue sclerae (HP:0000592)1.76586321
87Joint laxity (HP:0001388)1.76506942
88Ependymoma (HP:0002888)1.76200644
89Vertebral compression fractures (HP:0002953)1.75771650
90Broad thumb (HP:0011304)1.75698151
91Diplopia (HP:0000651)1.75450757
92Abnormality of binocular vision (HP:0011514)1.75450757
93Centrally nucleated skeletal muscle fibers (HP:0003687)1.75017311
94Striae distensae (HP:0001065)1.74623101
95Turricephaly (HP:0000262)1.74236800
96Vertebral arch anomaly (HP:0008438)1.73826043
97Arnold-Chiari malformation (HP:0002308)1.73161146
98Metaphyseal cupping (HP:0003021)1.69204426
99Abnormality of the thoracic spine (HP:0100711)1.68959844
100Neuronal loss in central nervous system (HP:0002529)1.68896604
101Achilles tendon contracture (HP:0001771)1.68343540
102Advanced eruption of teeth (HP:0006288)1.66094769
103Abnormality of oral frenula (HP:0000190)1.66034188
104Germ cell neoplasia (HP:0100728)1.65569227
105Sacral dimple (HP:0000960)1.65524761
106Amyotrophic lateral sclerosis (HP:0007354)1.65324706
107Fibroma (HP:0010614)1.65304988
108Obsessive-compulsive behavior (HP:0000722)1.64859976
109Difficulty running (HP:0009046)1.63474281
110Gingivitis (HP:0000230)1.63039958
111Cellulitis (HP:0100658)1.62841782
112Distal lower limb muscle weakness (HP:0009053)1.62206349
113Thin ribs (HP:0000883)1.61943887
114Diminished motivation (HP:0000745)1.61789233
115Dysostosis multiplex (HP:0000943)1.61290933
116Spinal canal stenosis (HP:0003416)1.61274670
117Peripheral hypomyelination (HP:0007182)1.61064031
118Fibrous tissue neoplasm (HP:0012316)1.60083103
119Spinal cord lesions (HP:0100561)1.59884265
120Syringomyelia (HP:0003396)1.59884265
121Ankle clonus (HP:0011448)1.59524851
122Absent frontal sinuses (HP:0002688)1.59362934
123Polygenic inheritance (HP:0010982)1.58813488
124Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.57650778
125Hypercortisolism (HP:0001578)1.57257982
126Premature rupture of membranes (HP:0001788)1.57206423
127Persistence of primary teeth (HP:0006335)1.57120537
128Papilledema (HP:0001085)1.56995480
129Aortic dissection (HP:0002647)1.56605007
130Increased cerebral lipofuscin (HP:0011813)1.56433522
131Aqueductal stenosis (HP:0002410)1.55192768
132Slow saccadic eye movements (HP:0000514)1.54917393
133Spondylolisthesis (HP:0003302)1.54894923
134Hypoventilation (HP:0002791)1.54672432
135Slender build (HP:0001533)1.54257488
136Leiomyosarcoma (HP:0100243)1.53928485
137Uterine leiomyosarcoma (HP:0002891)1.53928485
138Long toe (HP:0010511)1.53678943
139J-shaped sella turcica (HP:0002680)1.52735991
140Supernumerary nipples (HP:0002558)1.51668711
141Colitis (HP:0002583)1.51577050
142Interstitial pulmonary disease (HP:0006530)1.51063845
143Overgrowth (HP:0001548)1.50917445
144Frequent falls (HP:0002359)1.50166929
145Transitional cell carcinoma of the bladder (HP:0006740)1.49756747
146Thin bony cortex (HP:0002753)1.49600002
147Increased connective tissue (HP:0009025)1.49272378
148Abnormality of the diencephalon (HP:0010662)1.47786682
149Precocious puberty (HP:0000826)1.47433848
150Megalocornea (HP:0000485)1.44206495
151Long palpebral fissure (HP:0000637)1.43411425
152Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.42873133
153Action tremor (HP:0002345)1.42832574
154Atrophic scars (HP:0001075)1.42599212
155Malignant gastrointestinal tract tumors (HP:0006749)1.42028925
156Gastrointestinal carcinoma (HP:0002672)1.42028925
157Bladder neoplasm (HP:0009725)1.41607709
158Bladder carcinoma (HP:0002862)1.41607709
159Abnormality of the Achilles tendon (HP:0005109)1.41368375
160Pseudobulbar signs (HP:0002200)1.41065380

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.20903897
2PRPF4B3.69968896
3MAP3K103.45771421
4CDK123.33607543
5EEF2K3.19337382
6PKN23.13169392
7SMG12.52725840
8RIPK12.45729463
9ICK2.41869377
10SIK22.17639606
11ERN12.10694022
12MAP3K91.99291116
13CAMK1G1.86545417
14TAOK11.75974845
15PRKD31.70347255
16CAMK1D1.69902144
17PDGFRA1.64067282
18ALK1.61280683
19PTK61.58338147
20SIK11.57943960
21TYRO31.56260497
22TTN1.53267816
23BMX1.50686166
24MAP4K11.50631775
25MAP2K31.44455911
26PAK61.40803347
27RIPK41.39922459
28DMPK1.36296353
29IRAK31.33377498
30MAP3K131.32297244
31CAMKK11.31760882
32MTOR1.30923716
33LATS21.28960158
34KSR21.22754094
35MARK11.22361737
36SCYL21.14580142
37PRKCH1.14376799
38RET1.13480022
39MARK21.10715458
40DDR21.09371430
41DAPK21.08872014
42MAP3K61.07460657
43SIK31.06682717
44MAP3K71.00500830
45EPHB10.98973682
46MAP3K30.98329023
47ZAP700.96196666
48BRD40.95176940
49MAP3K110.94942437
50NTRK20.93482643
51TYK20.92356773
52NTRK10.90372920
53TAOK20.88731365
54GRK60.86570015
55PDGFRB0.86068411
56STK380.84990762
57EPHA20.83202936
58CDC42BPA0.82673170
59MAPK120.81517346
60PRKD20.79457717
61IRAK20.79393396
62PTK20.79336229
63SGK30.79271232
64LRRK20.79265755
65FGFR30.79016413
66RPS6KA20.78858935
67CDK60.76420430
68IRAK40.76057547
69MAPK70.75359867
70STK110.75287557
71PAK40.74117541
72PAK20.73373130
73NEK20.71691831
74LATS10.70896877
75HCK0.68952202
76BLK0.66308817
77CAMK40.65165928
78JAK10.64882599
79FGFR40.64079070
80KSR10.62524132
81MINK10.61912683
82STK100.61111869
83RPS6KA60.60816891
84JAK30.60571775
85WNK10.60230247
86TBK10.60087688
87BTK0.59462748
88HIPK20.59429208
89MAP3K40.58857618
90DYRK1B0.57945514
91MAP3K20.57705585
92TGFBR20.57676734
93EPHB20.57272950
94CDK40.55945666
95MST1R0.55582496
96MAPK110.55348613
97PRKD10.51162325
98ARAF0.51106589
99LMTK20.50790591
100UHMK10.49963613
101MAP2K20.49710580
102CSF1R0.48770590
103FGFR10.47780270
104PHKG20.47255249
105PHKG10.47255249
106MAP3K140.46595243
107CDK50.46425282
108JAK20.46342967
109TESK10.45963118
110PDK10.44244764
111NTRK30.43557652
112ERBB20.43001379
113FES0.42314067
114SGK2230.42105015
115SGK4940.42105015
116* MAPK80.39808341
117FYN0.39328815
118TNK20.38897755
119CSK0.38404377
120CDK90.37789078
121MAPK40.37445175
122CHUK0.36804678
123FGFR20.35943289
124SRC0.35857602
125MAPK100.35224039
126PDPK10.34920782
127DAPK10.34832423
128MATK0.34681453
129MAP3K10.34286680
130RPS6KC10.34174316
131RPS6KL10.34174316
132EGFR0.33777143

Predicted pathways (KEGG)

RankGene SetZ-score
1Chronic myeloid leukemia_Homo sapiens_hsa052201.77206983
2mTOR signaling pathway_Homo sapiens_hsa041501.66333219
3Other glycan degradation_Homo sapiens_hsa005111.63936205
4Glioma_Homo sapiens_hsa052141.55918560
5Neurotrophin signaling pathway_Homo sapiens_hsa047221.47513123
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46950054
7Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.46173579
8Non-small cell lung cancer_Homo sapiens_hsa052231.43094940
9Dorso-ventral axis formation_Homo sapiens_hsa043201.42921998
10B cell receptor signaling pathway_Homo sapiens_hsa046621.42412956
11Endometrial cancer_Homo sapiens_hsa052131.42381360
12Type II diabetes mellitus_Homo sapiens_hsa049301.38321720
13Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.35500802
14Thyroid hormone signaling pathway_Homo sapiens_hsa049191.35385490
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.33396598
16Notch signaling pathway_Homo sapiens_hsa043301.32804179
17Colorectal cancer_Homo sapiens_hsa052101.29478552
18VEGF signaling pathway_Homo sapiens_hsa043701.29113807
19Estrogen signaling pathway_Homo sapiens_hsa049151.27256995
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26604138
21Pancreatic cancer_Homo sapiens_hsa052121.23108679
22Proteoglycans in cancer_Homo sapiens_hsa052051.21433465
23Lysine degradation_Homo sapiens_hsa003101.21365952
24Renal cell carcinoma_Homo sapiens_hsa052111.20803048
25Acute myeloid leukemia_Homo sapiens_hsa052211.20465216
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.17337715
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16976304
28Focal adhesion_Homo sapiens_hsa045101.16631948
29Long-term potentiation_Homo sapiens_hsa047201.12523272
30Longevity regulating pathway - mammal_Homo sapiens_hsa042111.12323412
31ErbB signaling pathway_Homo sapiens_hsa040121.12045856
32Osteoclast differentiation_Homo sapiens_hsa043801.10162434
33Prion diseases_Homo sapiens_hsa050201.10025312
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09886382
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07723046
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06731773
37Phospholipase D signaling pathway_Homo sapiens_hsa040721.06564080
38Adherens junction_Homo sapiens_hsa045201.05735808
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04731143
40GnRH signaling pathway_Homo sapiens_hsa049121.04713227
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.03597689
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02586649
43Inositol phosphate metabolism_Homo sapiens_hsa005621.02515075
44Central carbon metabolism in cancer_Homo sapiens_hsa052301.02331585
45Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.01835325
46MicroRNAs in cancer_Homo sapiens_hsa052061.00758746
47Toll-like receptor signaling pathway_Homo sapiens_hsa046200.99818417
48Viral myocarditis_Homo sapiens_hsa054160.99066182
49Insulin resistance_Homo sapiens_hsa049310.98858687
50Platelet activation_Homo sapiens_hsa046110.98611952
51Olfactory transduction_Homo sapiens_hsa047400.98488319
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97363053
53Gastric acid secretion_Homo sapiens_hsa049710.97270850
54Prolactin signaling pathway_Homo sapiens_hsa049170.95849583
55Oxytocin signaling pathway_Homo sapiens_hsa049210.95844734
56Dilated cardiomyopathy_Homo sapiens_hsa054140.95355518
57Insulin signaling pathway_Homo sapiens_hsa049100.94872233
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94515257
59TNF signaling pathway_Homo sapiens_hsa046680.93809259
60Endocytosis_Homo sapiens_hsa041440.92929404
61Regulation of actin cytoskeleton_Homo sapiens_hsa048100.91274874
62Amoebiasis_Homo sapiens_hsa051460.90736169
63Circadian entrainment_Homo sapiens_hsa047130.90620845
64Gap junction_Homo sapiens_hsa045400.90457410
65Small cell lung cancer_Homo sapiens_hsa052220.90078394
66Cholinergic synapse_Homo sapiens_hsa047250.90026172
67Toxoplasmosis_Homo sapiens_hsa051450.89621726
68T cell receptor signaling pathway_Homo sapiens_hsa046600.89177376
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88316139
70Chemokine signaling pathway_Homo sapiens_hsa040620.88215105
71MAPK signaling pathway_Homo sapiens_hsa040100.88092423
72Salivary secretion_Homo sapiens_hsa049700.87110685
73Choline metabolism in cancer_Homo sapiens_hsa052310.86944645
74Axon guidance_Homo sapiens_hsa043600.86613523
75Hepatitis C_Homo sapiens_hsa051600.85912723
76Synaptic vesicle cycle_Homo sapiens_hsa047210.85466446
77Rap1 signaling pathway_Homo sapiens_hsa040150.85299580
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85280575
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84006726
80Hippo signaling pathway_Homo sapiens_hsa043900.83206875
81Bladder cancer_Homo sapiens_hsa052190.82227838
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81030486
83Thyroid cancer_Homo sapiens_hsa052160.80893864
84Basal cell carcinoma_Homo sapiens_hsa052170.80810710
85Influenza A_Homo sapiens_hsa051640.78249405
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.78017324
87Dopaminergic synapse_Homo sapiens_hsa047280.77372350
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77333372
89Melanogenesis_Homo sapiens_hsa049160.77232517
90Tuberculosis_Homo sapiens_hsa051520.76487086
91HTLV-I infection_Homo sapiens_hsa051660.75895028
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.75777080
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75480059
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75445535
95Hepatitis B_Homo sapiens_hsa051610.74702292
96Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74568535
97AMPK signaling pathway_Homo sapiens_hsa041520.74353927
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74209167
99Glutamatergic synapse_Homo sapiens_hsa047240.73980439
100Renin secretion_Homo sapiens_hsa049240.73022440
101cAMP signaling pathway_Homo sapiens_hsa040240.72604066
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72524865
103FoxO signaling pathway_Homo sapiens_hsa040680.72405539
104HIF-1 signaling pathway_Homo sapiens_hsa040660.71244210
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69960164
106Prostate cancer_Homo sapiens_hsa052150.69900287
107ECM-receptor interaction_Homo sapiens_hsa045120.69574228
108Insulin secretion_Homo sapiens_hsa049110.69548528
109Leishmaniasis_Homo sapiens_hsa051400.68277853
110Apoptosis_Homo sapiens_hsa042100.66999125
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.66675689
112Malaria_Homo sapiens_hsa051440.66410897
113Pathways in cancer_Homo sapiens_hsa052000.65682870
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65438113
115NF-kappa B signaling pathway_Homo sapiens_hsa040640.63406082
116Ras signaling pathway_Homo sapiens_hsa040140.61271946
117Measles_Homo sapiens_hsa051620.61033821

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