CICP12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.34938132
2DNA deamination (GO:0045006)5.03346176
3rRNA methylation (GO:0031167)4.95398909
4indolalkylamine metabolic process (GO:0006586)4.81476692
5kynurenine metabolic process (GO:0070189)4.81232179
6indole-containing compound catabolic process (GO:0042436)4.60160846
7indolalkylamine catabolic process (GO:0046218)4.60160846
8tryptophan catabolic process (GO:0006569)4.60160846
9synaptic transmission, cholinergic (GO:0007271)4.44088186
10negative regulation of translation, ncRNA-mediated (GO:0040033)4.40690097
11regulation of translation, ncRNA-mediated (GO:0045974)4.40690097
12negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.40690097
13rRNA modification (GO:0000154)4.37232804
14protein K11-linked deubiquitination (GO:0035871)4.35979010
15piRNA metabolic process (GO:0034587)4.30337018
16activated T cell proliferation (GO:0050798)4.27639062
17tryptophan metabolic process (GO:0006568)4.22628679
18regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.15399667
19positive regulation of defense response to virus by host (GO:0002230)4.01900947
20detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.99071344
21epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.86285218
22RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.79002252
23tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.79002252
24intra-S DNA damage checkpoint (GO:0031573)3.73267489
25positive regulation of mRNA catabolic process (GO:0061014)3.72650901
26mannosylation (GO:0097502)3.65592129
27L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.62645025
28L-methionine salvage (GO:0071267)3.48969462
29L-methionine biosynthetic process (GO:0071265)3.48969462
30amino acid salvage (GO:0043102)3.48969462
31mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.47644856
32positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.47644856
33epithelial cilium movement (GO:0003351)3.44420810
34peptidyl-histidine modification (GO:0018202)3.38570331
35preassembly of GPI anchor in ER membrane (GO:0016254)3.37276756
36platelet dense granule organization (GO:0060155)3.31915290
37photoreceptor cell maintenance (GO:0045494)3.31663006
38somite development (GO:0061053)3.31550073
39negative regulation of mast cell activation (GO:0033004)3.29390321
40regulation of cilium movement (GO:0003352)3.24669115
41indole-containing compound metabolic process (GO:0042430)3.23622686
42positive regulation of T-helper 1 type immune response (GO:0002827)3.18284699
43methionine biosynthetic process (GO:0009086)3.16239530
44peroxisome fission (GO:0016559)3.13997370
45cytochrome complex assembly (GO:0017004)3.11632011
46head development (GO:0060322)3.07355633
47amine catabolic process (GO:0009310)3.06021016
48cellular biogenic amine catabolic process (GO:0042402)3.06021016
49reciprocal DNA recombination (GO:0035825)3.05396953
50reciprocal meiotic recombination (GO:0007131)3.05396953
51cellular response to interferon-beta (GO:0035458)3.04639334
52detection of light stimulus involved in visual perception (GO:0050908)3.03436867
53detection of light stimulus involved in sensory perception (GO:0050962)3.03436867
54DNA methylation involved in gamete generation (GO:0043046)3.00017348
55regulation of defense response to virus by host (GO:0050691)2.99856609
56male meiosis I (GO:0007141)2.97485936
57S-adenosylmethionine metabolic process (GO:0046500)2.91779143
58regulation of mRNA catabolic process (GO:0061013)2.86605623
59attachment of spindle microtubules to kinetochore (GO:0008608)2.85199264
60transcription from mitochondrial promoter (GO:0006390)2.84859823
61protein complex biogenesis (GO:0070271)2.83635839
62regulation of posttranscriptional gene silencing (GO:0060147)2.83571481
63regulation of gene silencing by miRNA (GO:0060964)2.83571481
64regulation of gene silencing by RNA (GO:0060966)2.83571481
65intraciliary transport (GO:0042073)2.83471043
66spliceosomal tri-snRNP complex assembly (GO:0000244)2.82922382
67response to interferon-beta (GO:0035456)2.82014969
68protein-cofactor linkage (GO:0018065)2.80774055
69cellular response to exogenous dsRNA (GO:0071360)2.80141398
70RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.78485382
71acrosome assembly (GO:0001675)2.76697313
72GPI anchor metabolic process (GO:0006505)2.76319644
73respiratory chain complex IV assembly (GO:0008535)2.75509104
74endoderm formation (GO:0001706)2.75019454
75somatic diversification of immune receptors via somatic mutation (GO:0002566)2.74205408
76somatic hypermutation of immunoglobulin genes (GO:0016446)2.74205408
77ATP synthesis coupled proton transport (GO:0015986)2.70220086
78energy coupled proton transport, down electrochemical gradient (GO:0015985)2.70220086
79positive regulation of protein homodimerization activity (GO:0090073)2.66827001
80mitochondrial respiratory chain complex assembly (GO:0033108)2.64860184
81transmission of nerve impulse (GO:0019226)2.62508834
82GPI anchor biosynthetic process (GO:0006506)2.61733057
83benzene-containing compound metabolic process (GO:0042537)2.60062578
84resolution of meiotic recombination intermediates (GO:0000712)2.59313848
85nonmotile primary cilium assembly (GO:0035058)2.59310893
86methionine metabolic process (GO:0006555)2.56115591
87transcription elongation from RNA polymerase I promoter (GO:0006362)2.55397525
88cytidine deamination (GO:0009972)2.52000055
89cytidine metabolic process (GO:0046087)2.52000055
90cytidine catabolic process (GO:0006216)2.52000055
91positive regulation of antigen processing and presentation (GO:0002579)2.50785094
92mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.49871196
93sulfate transmembrane transport (GO:1902358)2.47391114
94brain morphogenesis (GO:0048854)2.46449094
95positive regulation of mitochondrial membrane permeability (GO:0035794)2.45846042
96nephron tubule morphogenesis (GO:0072078)2.45322808
97nephron epithelium morphogenesis (GO:0072088)2.45322808
98cerebral cortex neuron differentiation (GO:0021895)2.45202286
99cilium morphogenesis (GO:0060271)2.44482782
100neuronal action potential (GO:0019228)2.43268712

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.91196001
2VDR_22108803_ChIP-Seq_LS180_Human3.44692770
3ZNF274_21170338_ChIP-Seq_K562_Hela3.42991693
4GBX2_23144817_ChIP-Seq_PC3_Human2.69543901
5ELF1_17652178_ChIP-ChIP_JURKAT_Human2.53700252
6EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.34561193
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.33501599
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.21621289
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.17113177
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08807290
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.03283231
12SALL1_21062744_ChIP-ChIP_HESCs_Human1.94869183
13ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88147142
14ER_23166858_ChIP-Seq_MCF-7_Human1.85891966
15IGF1R_20145208_ChIP-Seq_DFB_Human1.81826938
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77719492
17FUS_26573619_Chip-Seq_HEK293_Human1.69691548
18EWS_26573619_Chip-Seq_HEK293_Human1.65240090
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65100747
20POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64837859
21IRF8_22096565_ChIP-ChIP_GC-B_Human1.61968568
22EZH2_22144423_ChIP-Seq_EOC_Human1.61810488
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60971937
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59524237
25CBP_20019798_ChIP-Seq_JUKART_Human1.53761975
26IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53761975
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48795906
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.46718358
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46534593
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.46492439
31PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.45390666
32GATA3_21878914_ChIP-Seq_MCF-7_Human1.45207909
33GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.40733412
34ELK1_19687146_ChIP-ChIP_HELA_Human1.39987540
35IRF1_19129219_ChIP-ChIP_H3396_Human1.39747617
36TP53_22573176_ChIP-Seq_HFKS_Human1.37427192
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37292831
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35382158
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34734518
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.34263615
41FOXA1_25329375_ChIP-Seq_VCAP_Human1.34056787
42FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34056787
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33623779
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32108646
45CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.32031335
46P300_19829295_ChIP-Seq_ESCs_Human1.30802278
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.27003784
48SMAD4_21799915_ChIP-Seq_A2780_Human1.25754157
49MYC_18940864_ChIP-ChIP_HL60_Human1.25097215
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.24866009
51VDR_23849224_ChIP-Seq_CD4+_Human1.24047493
52NCOR_22424771_ChIP-Seq_293T_Human1.23365729
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22686989
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.22570854
55REST_21632747_ChIP-Seq_MESCs_Mouse1.20479615
56SOX2_19829295_ChIP-Seq_ESCs_Human1.20194199
57NANOG_19829295_ChIP-Seq_ESCs_Human1.20194199
58RNF2_27304074_Chip-Seq_NSC_Mouse1.19972640
59EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19283835
60NANOG_20526341_ChIP-Seq_ESCs_Human1.19038678
61AR_21572438_ChIP-Seq_LNCaP_Human1.17989317
62STAT3_23295773_ChIP-Seq_U87_Human1.17959051
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.17277189
64MYC_19829295_ChIP-Seq_ESCs_Human1.16502883
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16483467
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16483467
67SRF_21415370_ChIP-Seq_HL-1_Mouse1.16035404
68KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.15463623
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15440926
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14950989
71EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.14312290
72AR_20517297_ChIP-Seq_VCAP_Human1.14117214
73ETS1_20019798_ChIP-Seq_JURKAT_Human1.13765985
74TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.13749199
75FLI1_21867929_ChIP-Seq_TH2_Mouse1.13546997
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13254141
77HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13180129
78ERA_21632823_ChIP-Seq_H3396_Human1.11970113
79BCAT_22108803_ChIP-Seq_LS180_Human1.09785783
80TAF2_19829295_ChIP-Seq_ESCs_Human1.09189811
81CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.08596513
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08141731
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05744443
84P53_22387025_ChIP-Seq_ESCs_Mouse1.05046651
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04670435
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04533280
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.03843876
88AR_25329375_ChIP-Seq_VCAP_Human1.03252323
89TCF4_23295773_ChIP-Seq_U87_Human1.03129918
90HOXB7_26014856_ChIP-Seq_BT474_Human1.02773801
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02511139
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.02121828
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02054011
94TCF4_22108803_ChIP-Seq_LS180_Human1.01566563
95P53_21459846_ChIP-Seq_SAOS-2_Human1.00972700
96RAC3_21632823_ChIP-Seq_H3396_Human1.00966379
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00556500
98E2F1_18555785_Chip-Seq_ESCs_Mouse1.00433674
99EST1_17652178_ChIP-ChIP_JURKAT_Human1.00297826
100CRX_20693478_ChIP-Seq_RETINA_Mouse0.99361473

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue3.74133026
2MP0008877_abnormal_DNA_methylation3.15837107
3MP0002638_abnormal_pupillary_reflex2.98494361
4MP0004885_abnormal_endolymph2.92421771
5MP0005075_abnormal_melanosome_morpholog2.81786185
6MP0010386_abnormal_urinary_bladder2.73797745
7MP0005551_abnormal_eye_electrophysiolog2.51298962
8MP0006072_abnormal_retinal_apoptosis2.35810154
9MP0000569_abnormal_digit_pigmentation2.30092952
10MP0006276_abnormal_autonomic_nervous2.18506266
11MP0008872_abnormal_physiological_respon2.16867175
12MP0004130_abnormal_muscle_cell2.06319842
13MP0001529_abnormal_vocalization2.01814413
14MP0005084_abnormal_gallbladder_morpholo1.98141860
15MP0003787_abnormal_imprinting1.96929490
16MP0005253_abnormal_eye_physiology1.89295912
17MP0000427_abnormal_hair_cycle1.78790675
18MP0002876_abnormal_thyroid_physiology1.78213935
19MP0004147_increased_porphyrin_level1.71813850
20MP0003879_abnormal_hair_cell1.65168285
21MP0001324_abnormal_eye_pigmentation1.62490005
22MP0003195_calcinosis1.60311814
23MP0000538_abnormal_urinary_bladder1.54421153
24MP0008789_abnormal_olfactory_epithelium1.54354056
25MP0001968_abnormal_touch/_nociception1.53759377
26MP0008875_abnormal_xenobiotic_pharmacok1.51811368
27MP0008775_abnormal_heart_ventricle1.50685245
28MP0004133_heterotaxia1.50537509
29MP0002736_abnormal_nociception_after1.49264443
30MP0001905_abnormal_dopamine_level1.48055833
31MP0004142_abnormal_muscle_tone1.46599212
32MP0003122_maternal_imprinting1.45905993
33MP0002938_white_spotting1.45483728
34MP0005386_behavior/neurological_phenoty1.42272187
35MP0004924_abnormal_behavior1.42272187
36MP0002735_abnormal_chemical_nociception1.42253638
37MP0009745_abnormal_behavioral_response1.38003614
38MP0002837_dystrophic_cardiac_calcinosis1.34187892
39MP0005174_abnormal_tail_pigmentation1.30822978
40MP0003011_delayed_dark_adaptation1.29821929
41MP0005195_abnormal_posterior_eye1.26772619
42MP0004215_abnormal_myocardial_fiber1.26766924
43MP0002752_abnormal_somatic_nervous1.25168865
44MP0001986_abnormal_taste_sensitivity1.23613478
45MP0000778_abnormal_nervous_system1.23312246
46MP0002928_abnormal_bile_duct1.23193492
47MP0004742_abnormal_vestibular_system1.22802740
48MP0009046_muscle_twitch1.21783549
49MP0005671_abnormal_response_to1.20387293
50MP0002572_abnormal_emotion/affect_behav1.19568316
51MP0003121_genomic_imprinting1.18546876
52MP0001270_distended_abdomen1.16343697
53MP0002272_abnormal_nervous_system1.13256051
54MP0002653_abnormal_ependyma_morphology1.12197660
55MP0005503_abnormal_tendon_morphology1.11431369
56MP0002102_abnormal_ear_morphology1.10978557
57MP0002557_abnormal_social/conspecific_i1.10250478
58MP0004270_analgesia1.10182935
59MP0001963_abnormal_hearing_physiology1.08802283
60MP0004145_abnormal_muscle_electrophysio1.03161250
61MP0005389_reproductive_system_phenotype1.02762010
62MP0001501_abnormal_sleep_pattern1.02648782
63MP0001440_abnormal_grooming_behavior1.02397004
64MP0002160_abnormal_reproductive_system1.01766195
65MP0000026_abnormal_inner_ear1.01657619
66MP0000015_abnormal_ear_pigmentation1.01480304
67MP0001485_abnormal_pinna_reflex0.99936860
68MP0001502_abnormal_circadian_rhythm0.98489406
69MP0000230_abnormal_systemic_arterial0.97824985
70MP0000372_irregular_coat_pigmentation0.97145929
71MP0004043_abnormal_pH_regulation0.96451326
72MP0002138_abnormal_hepatobiliary_system0.95923979
73MP0009764_decreased_sensitivity_to0.92760808
74MP0003878_abnormal_ear_physiology0.90710920
75MP0005377_hearing/vestibular/ear_phenot0.90710920
76MP0001727_abnormal_embryo_implantation0.90462532
77MP0001764_abnormal_homeostasis0.90363389
78MP0005646_abnormal_pituitary_gland0.88979943
79MP0001835_abnormal_antigen_presentation0.88460940
80MP0001984_abnormal_olfaction0.87049989
81MP0003635_abnormal_synaptic_transmissio0.85485605
82MP0005332_abnormal_amino_acid0.84512412
83MP0006054_spinal_hemorrhage0.84369470
84MP0002063_abnormal_learning/memory/cond0.82558375
85MP0001800_abnormal_humoral_immune0.81906455
86MP0002277_abnormal_respiratory_mucosa0.81242034
87MP0002184_abnormal_innervation0.79970330
88MP0002229_neurodegeneration0.79334461
89MP0001919_abnormal_reproductive_system0.79235880
90MP0002733_abnormal_thermal_nociception0.79031695
91MP0009115_abnormal_fat_cell0.78476504
92MP0004264_abnormal_extraembryonic_tissu0.78332048
93MP0002282_abnormal_trachea_morphology0.78133024
94MP0003698_abnormal_male_reproductive0.77797490
95MP0000631_abnormal_neuroendocrine_gland0.77613529
96MP0001970_abnormal_pain_threshold0.76813250
97MP0002095_abnormal_skin_pigmentation0.75991682
98MP0002067_abnormal_sensory_capabilities0.74815767
99MP0002693_abnormal_pancreas_physiology0.74269252
100MP0002210_abnormal_sex_determination0.74214782

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic fibrosis (HP:0100732)4.39469596
2Pancreatic cysts (HP:0001737)4.08105000
3Abnormality of midbrain morphology (HP:0002418)3.81830240
4Molar tooth sign on MRI (HP:0002419)3.81830240
5Chronic hepatic failure (HP:0100626)3.60502704
6True hermaphroditism (HP:0010459)3.55763937
7Type II lissencephaly (HP:0007260)3.51722627
8Papilledema (HP:0001085)3.35236638
9Degeneration of the lateral corticospinal tracts (HP:0002314)3.24916735
10Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.24916735
11Medial flaring of the eyebrow (HP:0010747)3.20515819
12Nephronophthisis (HP:0000090)3.14893608
13Congenital stationary night blindness (HP:0007642)3.13729982
14Abnormality of the renal medulla (HP:0100957)3.11556595
15Gait imbalance (HP:0002141)2.93417111
16Decreased electroretinogram (ERG) amplitude (HP:0000654)2.92944497
17Decreased central vision (HP:0007663)2.80748934
18Congenital primary aphakia (HP:0007707)2.76502606
19Nephrogenic diabetes insipidus (HP:0009806)2.72021573
20Abnormality of the renal cortex (HP:0011035)2.71813527
21Bile duct proliferation (HP:0001408)2.69514140
22Abnormal biliary tract physiology (HP:0012439)2.69514140
23Cystic liver disease (HP:0006706)2.64420860
24Abolished electroretinogram (ERG) (HP:0000550)2.61352917
25Progressive inability to walk (HP:0002505)2.57151877
26Increased corneal curvature (HP:0100692)2.55320446
27Keratoconus (HP:0000563)2.55320446
28Abnormality of the corticospinal tract (HP:0002492)2.47554905
29Attenuation of retinal blood vessels (HP:0007843)2.44948030
30Concave nail (HP:0001598)2.44188942
31Hepatocellular necrosis (HP:0001404)2.43281047
32Hepatic necrosis (HP:0002605)2.40267948
33Abnormal drinking behavior (HP:0030082)2.36008295
34Polydipsia (HP:0001959)2.36008295
35Inability to walk (HP:0002540)2.33743363
36Chronic sinusitis (HP:0011109)2.29752192
37Albinism (HP:0001022)2.27783717
38Hyperventilation (HP:0002883)2.24659344
39Alveolar cell carcinoma (HP:0006519)2.23555587
40Genital tract atresia (HP:0001827)2.22784611
41Macular degeneration (HP:0000608)2.22254790
42Renal cortical cysts (HP:0000803)2.22205379
43Polyphagia (HP:0002591)2.17708466
44Sclerocornea (HP:0000647)2.14778556
45Abnormality of the pons (HP:0007361)2.13895422
46Congenital hepatic fibrosis (HP:0002612)2.12910028
47Cerebellar dysplasia (HP:0007033)2.12682865
48Methylmalonic aciduria (HP:0012120)2.12142757
49Vaginal atresia (HP:0000148)2.09358576
50Polyuria (HP:0000103)2.09094246
51Hyperglycinemia (HP:0002154)2.07768641
52Abnormal rod and cone electroretinograms (HP:0008323)2.06912085
533-Methylglutaconic aciduria (HP:0003535)2.05417856
54Increased CSF lactate (HP:0002490)2.04664458
55Gaze-evoked nystagmus (HP:0000640)2.03668939
56Hypoplasia of the pons (HP:0012110)2.02111421
57Anterior segment dysgenesis (HP:0007700)2.01980555
58Lipid accumulation in hepatocytes (HP:0006561)2.01169880
59Poor coordination (HP:0002370)2.01167586
60Mitochondrial inheritance (HP:0001427)2.00913189
61Furrowed tongue (HP:0000221)1.98838633
62Agitation (HP:0000713)1.95896887
63Hemiparesis (HP:0001269)1.95289462
64Focal seizures (HP:0007359)1.95089761
65Thyroiditis (HP:0100646)1.94614046
66Ketosis (HP:0001946)1.93148470
67Dynein arm defect of respiratory motile cilia (HP:0012255)1.92697097
68Absent/shortened dynein arms (HP:0200106)1.92697097
69Severe muscular hypotonia (HP:0006829)1.91350881
70Aplasia/Hypoplasia of the tongue (HP:0010295)1.90557037
71Anencephaly (HP:0002323)1.87599664
72Methylmalonic acidemia (HP:0002912)1.86365459
73Neoplasm of the tracheobronchial system (HP:0100552)1.86265112
74Aplasia/Hypoplasia of the uvula (HP:0010293)1.85493730
75Severe combined immunodeficiency (HP:0004430)1.85259897
76Abnormality of the vertebral endplates (HP:0005106)1.84199008
77Lissencephaly (HP:0001339)1.83048526
78Hypoplasia of the uterus (HP:0000013)1.82867875
79Cone-rod dystrophy (HP:0000548)1.81675835
80Large for gestational age (HP:0001520)1.81199310
81Bulbous nose (HP:0000414)1.78440735
82Aplasia/Hypoplasia of the spleen (HP:0010451)1.77920525
83Small hand (HP:0200055)1.77051248
84Febrile seizures (HP:0002373)1.76723051
85Tubular atrophy (HP:0000092)1.76554749
86Type I transferrin isoform profile (HP:0003642)1.76529680
87Aplasia/hypoplasia of the uterus (HP:0008684)1.75911842
88Genetic anticipation (HP:0003743)1.75555153
89Type 2 muscle fiber atrophy (HP:0003554)1.74630114
90Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.74515626
91Pachygyria (HP:0001302)1.74323914
92CNS demyelination (HP:0007305)1.72373789
93Postaxial foot polydactyly (HP:0001830)1.70794078
94Cerebral hypomyelination (HP:0006808)1.70542753
95Optic disc pallor (HP:0000543)1.68677157
96Aplasia/Hypoplasia of the lens (HP:0008063)1.68658786
97Abnormal respiratory epithelium morphology (HP:0012253)1.67996568
98Abnormal respiratory motile cilium morphology (HP:0005938)1.67996568
99Occipital encephalocele (HP:0002085)1.67915731
100IgG deficiency (HP:0004315)1.67626701

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK36.49315739
2NUAK13.52177765
3FRK3.08856398
4VRK12.75866792
5SIK32.49163068
6TAF12.23767095
7TNIK2.23420788
8DYRK1B2.18951980
9TRIM282.15169662
10WNK42.10359438
11KIT2.09978768
12MAPK131.90341609
13CAMKK21.77536626
14OXSR11.68795810
15EIF2AK31.63111593
16AKT31.56049834
17STK161.49724281
18CDK31.47310913
19TLK11.45043153
20GRK11.40497364
21PIM21.38570448
22EPHB21.36629467
23MAP4K21.36219180
24PINK11.35986438
25FLT31.28677066
26PNCK1.23959331
27PIK3CA1.21299355
28NTRK21.21175188
29ADRBK21.19402268
30MAP2K61.18544679
31PHKG21.18431637
32PHKG11.18431637
33CDK191.17186626
34RIPK11.14178169
35VRK21.14044368
36STK391.12981227
37ACVR1B1.11856098
38WNK31.10047901
39TRPM71.06835934
40BCR1.02040693
41MAPK151.01112076
42TYK20.99926040
43IKBKB0.96993782
44IKBKE0.89668319
45SIK20.87205219
46NTRK10.86755527
47MUSK0.85968930
48BMPR1B0.85829131
49TXK0.85818674
50NME10.84833019
51MAPK110.83594647
52PLK30.78935728
53MAPKAPK50.76030961
54PRKCQ0.75970945
55PRKG20.74606692
56MAP3K60.73863743
57STK110.73253864
58PAK30.72852146
59PRKCE0.71732286
60ABL20.66891515
61PRKAA10.66524327
62EIF2AK10.63982972
63DYRK1A0.63394701
64ADRBK10.62347158
65MAP3K140.62090379
66FES0.61884301
67MARK30.57079364
68CAMK10.56481150
69CHUK0.55297146
70NTRK30.53873235
71ZAK0.53504885
72ILK0.52612001
73PKN10.51697810
74TYRO30.50754040
75JAK30.50686492
76IRAK40.49738670
77BCKDK0.49589022
78MARK10.48507381
79MAP2K70.47358434
80ABL10.45747350
81MARK20.45279116
82TNK20.45275145
83MAP3K110.45064791
84PIK3CG0.44603152
85PKN20.43358453
86MAPKAPK30.42484789
87PRKG10.40856732
88CAMKK10.40522309
89PRKCZ0.39429645
90PIM10.38878498
91IGF1R0.37368360
92DYRK20.36171945
93NEK10.33866647
94MAP3K40.33406618
95PRKACA0.33069694
96MAPK70.32475600
97CASK0.31773226
98CSNK1A10.30519099
99PRKD20.30344452
100BTK0.28018021

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.17892432
2Tryptophan metabolism_Homo sapiens_hsa003803.06215670
3Basal transcription factors_Homo sapiens_hsa030222.73030802
4Oxidative phosphorylation_Homo sapiens_hsa001902.68680276
5Linoleic acid metabolism_Homo sapiens_hsa005912.52970700
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.48438802
7Phototransduction_Homo sapiens_hsa047442.26730647
8Homologous recombination_Homo sapiens_hsa034402.26241788
9Parkinsons disease_Homo sapiens_hsa050122.17380879
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.13999672
11Dorso-ventral axis formation_Homo sapiens_hsa043201.98976488
12Ether lipid metabolism_Homo sapiens_hsa005651.93047982
13One carbon pool by folate_Homo sapiens_hsa006701.90857706
14Peroxisome_Homo sapiens_hsa041461.80334827
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.73339780
16Fanconi anemia pathway_Homo sapiens_hsa034601.70523160
17Olfactory transduction_Homo sapiens_hsa047401.64078444
18RNA degradation_Homo sapiens_hsa030181.62231465
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.61570015
20Selenocompound metabolism_Homo sapiens_hsa004501.54746110
21Proteasome_Homo sapiens_hsa030501.45648558
22Mismatch repair_Homo sapiens_hsa034301.44808398
23Collecting duct acid secretion_Homo sapiens_hsa049661.39557597
24Protein export_Homo sapiens_hsa030601.35147630
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31590926
26Nicotine addiction_Homo sapiens_hsa050331.30175637
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30141788
28RNA polymerase_Homo sapiens_hsa030201.29583171
29Primary immunodeficiency_Homo sapiens_hsa053401.28672155
30Nitrogen metabolism_Homo sapiens_hsa009101.25522062
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25299224
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.24509875
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.23838695
34Fatty acid elongation_Homo sapiens_hsa000621.23371785
35Alzheimers disease_Homo sapiens_hsa050101.21997293
36Huntingtons disease_Homo sapiens_hsa050161.20747844
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.19445668
38Butanoate metabolism_Homo sapiens_hsa006501.18264277
39ABC transporters_Homo sapiens_hsa020101.18251628
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.17107180
41Arachidonic acid metabolism_Homo sapiens_hsa005901.07572248
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07479173
43Fat digestion and absorption_Homo sapiens_hsa049751.06182282
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.04648787
45Nucleotide excision repair_Homo sapiens_hsa034201.04069164
46Intestinal immune network for IgA production_Homo sapiens_hsa046721.01084859
47Insulin secretion_Homo sapiens_hsa049110.98921319
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.98901169
49Cardiac muscle contraction_Homo sapiens_hsa042600.96435498
50Glycerolipid metabolism_Homo sapiens_hsa005610.95921838
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92778325
52Chemical carcinogenesis_Homo sapiens_hsa052040.92129160
53Ribosome_Homo sapiens_hsa030100.89839315
54Caffeine metabolism_Homo sapiens_hsa002320.87875619
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86642070
56Taste transduction_Homo sapiens_hsa047420.85576917
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84784307
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84455723
59Sulfur metabolism_Homo sapiens_hsa009200.80657342
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78552222
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78550407
62Amphetamine addiction_Homo sapiens_hsa050310.77852782
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77581028
64Dopaminergic synapse_Homo sapiens_hsa047280.76906335
65Propanoate metabolism_Homo sapiens_hsa006400.76081845
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72072433
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70609404
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70294406
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69904959
70Purine metabolism_Homo sapiens_hsa002300.68204237
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66949781
72Metabolic pathways_Homo sapiens_hsa011000.64348866
73Histidine metabolism_Homo sapiens_hsa003400.60104304
74Cocaine addiction_Homo sapiens_hsa050300.60030066
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56422668
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55604724
77T cell receptor signaling pathway_Homo sapiens_hsa046600.50993505
78Retinol metabolism_Homo sapiens_hsa008300.50903037
79Sulfur relay system_Homo sapiens_hsa041220.50652465
80Serotonergic synapse_Homo sapiens_hsa047260.50194881
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.48611329
82Salivary secretion_Homo sapiens_hsa049700.44728911
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43226962
84Fatty acid metabolism_Homo sapiens_hsa012120.41800759
85N-Glycan biosynthesis_Homo sapiens_hsa005100.39377404
86Melanoma_Homo sapiens_hsa052180.39318105
87Morphine addiction_Homo sapiens_hsa050320.35628161
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35063777
89Lysine degradation_Homo sapiens_hsa003100.34758416
90Regulation of autophagy_Homo sapiens_hsa041400.34380723
91Oxytocin signaling pathway_Homo sapiens_hsa049210.34177549
92Mineral absorption_Homo sapiens_hsa049780.33998545
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.33932568
94Cholinergic synapse_Homo sapiens_hsa047250.33652898
95Renin secretion_Homo sapiens_hsa049240.33573793
96Glutamatergic synapse_Homo sapiens_hsa047240.32238818
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32143612
98Circadian entrainment_Homo sapiens_hsa047130.31362322
99RNA transport_Homo sapiens_hsa030130.29731748
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29561741

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