CICP14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.10641121
2mannose metabolic process (GO:0006013)4.45303879
3positive regulation of gamma-delta T cell activation (GO:0046645)4.18408181
4regulation of gamma-delta T cell differentiation (GO:0045586)3.87574913
5positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.78104304
6regulation of gamma-delta T cell activation (GO:0046643)3.76245103
7histone H3-K36 demethylation (GO:0070544)3.53417044
8response to muramyl dipeptide (GO:0032495)3.41975401
9positive thymic T cell selection (GO:0045059)3.31465753
10cellular extravasation (GO:0045123)3.26824842
11positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.24969525
12negative regulation of myotube differentiation (GO:0010832)3.23684531
13thymic T cell selection (GO:0045061)3.22753522
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.20501708
15negative regulation of cell killing (GO:0031342)3.20501708
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.14990306
17regulation of ARF GTPase activity (GO:0032312)3.11089035
18histone H3-K4 trimethylation (GO:0080182)3.03161833
19germinal center formation (GO:0002467)2.97908698
20antigen processing and presentation of endogenous antigen (GO:0019883)2.96644502
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.91931706
22detection of other organism (GO:0098543)2.90237628
23T cell selection (GO:0045058)2.88337215
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.85083336
25response to peptidoglycan (GO:0032494)2.84152188
26positive regulation of histone deacetylation (GO:0031065)2.83738279
27regulation of histone H3-K27 methylation (GO:0061085)2.81820390
28detection of bacterium (GO:0016045)2.80384383
29positive T cell selection (GO:0043368)2.80205217
30insulin-like growth factor receptor signaling pathway (GO:0048009)2.80039639
31positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.78341386
32negative thymic T cell selection (GO:0045060)2.78171747
33regulation of ARF protein signal transduction (GO:0032012)2.75455340
34negative regulation of fatty acid transport (GO:2000192)2.75077920
35macrophage activation involved in immune response (GO:0002281)2.68249689
36embryonic process involved in female pregnancy (GO:0060136)2.67722409
37detection of molecule of bacterial origin (GO:0032490)2.66711370
38positive regulation by symbiont of host defense response (GO:0052509)2.65516551
39modulation by symbiont of host defense response (GO:0052031)2.65516551
40modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.65516551
41modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.65516551
42positive regulation by organism of defense response of other organism involved in symbiotic interact2.65516551
43modulation by symbiont of host immune response (GO:0052553)2.65516551
44histone H3-K4 methylation (GO:0051568)2.65511405
45B cell receptor signaling pathway (GO:0050853)2.65197093
46detection of external biotic stimulus (GO:0098581)2.64920299
47histone lysine demethylation (GO:0070076)2.64248419
48semaphorin-plexin signaling pathway (GO:0071526)2.62773579
49response to laminar fluid shear stress (GO:0034616)2.62339441
50focal adhesion assembly (GO:0048041)2.61680446
51cell-substrate adherens junction assembly (GO:0007045)2.61680446
52negative T cell selection (GO:0043383)2.58831884
53negative regulation of cell size (GO:0045792)2.56880749
54regulation of type I interferon-mediated signaling pathway (GO:0060338)2.55901226
55negative regulation of interleukin-8 production (GO:0032717)2.55683019
56regulation of necroptotic process (GO:0060544)2.55542976
57adherens junction assembly (GO:0034333)2.54903509
58regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.54591988
59intracellular estrogen receptor signaling pathway (GO:0030520)2.51179497
60histone demethylation (GO:0016577)2.50631740
613-UTR-mediated mRNA stabilization (GO:0070935)2.50436176
62positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.50252206
63activation of JUN kinase activity (GO:0007257)2.48899649
64regulation of NFAT protein import into nucleus (GO:0051532)2.47342845
65regulation of B cell receptor signaling pathway (GO:0050855)2.45589340
66positive regulation of protein deacetylation (GO:0090312)2.44752117
67epithelial cell differentiation involved in prostate gland development (GO:0060742)2.44637481
68histone H3-K9 demethylation (GO:0033169)2.43959268
69apoptotic process involved in morphogenesis (GO:0060561)2.43677620
70negative regulation of granulocyte differentiation (GO:0030853)2.41250880
71cellular response to virus (GO:0098586)2.40202239
72leukocyte aggregation (GO:0070486)2.40182901
73endothelial cell chemotaxis (GO:0035767)2.37798889
74negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.36720054
75positive regulation of B cell differentiation (GO:0045579)2.35741615
76positive regulation of Rap GTPase activity (GO:0032854)2.35124620
77histone H3-K9 modification (GO:0061647)2.35093390
78histone H4 deacetylation (GO:0070933)2.34979471
79regulation of monocyte differentiation (GO:0045655)2.34854080
80cell-substrate junction assembly (GO:0007044)2.34632645
81positive regulation of blood vessel endothelial cell migration (GO:0043536)2.33831791
82positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.33317236
83detection of biotic stimulus (GO:0009595)2.32572253
84regulation of glucose import in response to insulin stimulus (GO:2001273)2.31515006
85Peyers patch development (GO:0048541)2.30352623
86mucosal-associated lymphoid tissue development (GO:0048537)2.30352623
87regulation of leukocyte degranulation (GO:0043300)2.29464303
88regulation of fatty acid beta-oxidation (GO:0031998)2.28005683
89phospholipid scrambling (GO:0017121)2.27513228
90antigen processing and presentation via MHC class Ib (GO:0002475)2.27300849
91definitive hemopoiesis (GO:0060216)2.24927563
92regulation of myeloid leukocyte mediated immunity (GO:0002886)2.24174276
93cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.23366034
94atrioventricular valve morphogenesis (GO:0003181)2.22843276
95negative regulation of toll-like receptor signaling pathway (GO:0034122)2.22561214
96positive regulation of receptor recycling (GO:0001921)2.22534139
97positive regulation of granulocyte differentiation (GO:0030854)2.22327118
98JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.21941777
99stress fiber assembly (GO:0043149)2.20854420
100positive regulation of protein kinase C signaling (GO:0090037)2.20848670

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.33439613
2MYC_22102868_ChIP-Seq_BL_Human3.09304813
3KDM2B_26808549_Chip-Seq_SUP-B15_Human3.07115098
4TCF7_22412390_ChIP-Seq_EML_Mouse2.75692107
5KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.74198037
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.63719166
7KDM2B_26808549_Chip-Seq_DND41_Human2.58665878
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.58123320
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.50654319
10LXR_22292898_ChIP-Seq_THP-1_Human2.47806291
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.41097004
12ELK3_25401928_ChIP-Seq_HUVEC_Human2.37678926
13VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.35858735
14VDR_24763502_ChIP-Seq_THP-1_Human2.35397374
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.24060277
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.17750244
17KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.15853782
18SCL_19346495_ChIP-Seq_HPC-7_Human2.13403655
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.09519842
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.08886353
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.01057797
22KDM2B_26808549_Chip-Seq_K562_Human1.92688870
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.90999554
24BP1_19119308_ChIP-ChIP_Hs578T_Human1.90900038
25MAF_26560356_Chip-Seq_TH1_Human1.90684554
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.89713087
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89295972
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.88555851
29KDM2B_26808549_Chip-Seq_JURKAT_Human1.87328989
30RACK7_27058665_Chip-Seq_MCF-7_Human1.83873133
31UTX_26944678_Chip-Seq_JUKART_Human1.77832197
32SPI1_23127762_ChIP-Seq_K562_Human1.70186487
33SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68782138
34GATA1_19941827_ChIP-Seq_MEL_Mouse1.67213317
35MAF_26560356_Chip-Seq_TH2_Human1.66258866
36DROSHA_22980978_ChIP-Seq_HELA_Human1.63390479
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.61675370
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.60776785
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.58927653
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54739472
41NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54636953
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.54029488
43RUNX1_27514584_Chip-Seq_MCF-7_Human1.52182391
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.51620849
45EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.50371490
46GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.49810434
47TP63_17297297_ChIP-ChIP_HaCaT_Human1.44069969
48RUNX_20019798_ChIP-Seq_JUKART_Human1.43882199
49SMC4_20622854_ChIP-Seq_HELA_Human1.43787693
50TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.43230001
51CTCF_27219007_Chip-Seq_ERYTHROID_Human1.39541218
52ZFP281_27345836_Chip-Seq_ESCs_Mouse1.38646869
53MYB_21317192_ChIP-Seq_ERMYB_Mouse1.37863298
54P68_20966046_ChIP-Seq_HELA_Human1.37163032
55GATA1_19941826_ChIP-Seq_K562_Human1.36330982
56FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.35054110
57TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34970424
58MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.32067832
59RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31251741
60SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29234064
61DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.27592241
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.27203831
63CREB1_26743006_Chip-Seq_LNCaP_Human1.26860035
64SA1_27219007_Chip-Seq_ERYTHROID_Human1.26178809
65SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25406890
66CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23856785
67RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22794236
68WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21959566
69EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.21630197
70ZFP281_18757296_ChIP-ChIP_E14_Mouse1.21381769
71P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20512923
72MYB_26560356_Chip-Seq_TH1_Human1.18728156
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18075286
74NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17729527
75NCOR1_26117541_ChIP-Seq_K562_Human1.16667926
76IRF8_27001747_Chip-Seq_BMDM_Mouse1.15605646
77KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14352447
78DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12885256
79CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11689779
80UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10017404
81GATA2_21666600_ChIP-Seq_HMVEC_Human1.09649323
82GATA1_22025678_ChIP-Seq_K562_Human1.08732458
83MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07630433
84NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.07293267
85GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06678260
86PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05127363
87TBX20_22328084_ChIP-Seq_HEART_Mouse1.04502751
88TBX20_22080862_ChIP-Seq_HEART_Mouse1.04502751
89SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03492879
90BCOR_27268052_Chip-Seq_Bcells_Human1.03363098
91GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01484207
92MYB_26560356_Chip-Seq_TH2_Human1.00373127
93ERG_21242973_ChIP-ChIP_JURKAT_Human1.00194462
94STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.99796885
95TP53_22127205_ChIP-Seq_IMR90_Human0.99280164
96TP63_22573176_ChIP-Seq_HFKS_Human0.98489527
97ELF1_20517297_ChIP-Seq_JURKAT_Human0.97423072
98TET1_21451524_ChIP-Seq_MESCs_Mouse0.95468269
99IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93989169
100CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91656186

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.45466825
2MP0009278_abnormal_bone_marrow3.36926581
3MP0003303_peritoneal_inflammation3.34599734
4MP0005076_abnormal_cell_differentiation2.95206780
5MP0003436_decreased_susceptibility_to2.70235263
6MP0003172_abnormal_lysosome_physiology2.46575882
7MP0005451_abnormal_body_composition2.39244495
8MP0003763_abnormal_thymus_physiology2.37551739
9MP0005409_darkened_coat_color2.32197042
10MP0002396_abnormal_hematopoietic_system2.25198483
11MP0004381_abnormal_hair_follicle2.20902263
12MP0008260_abnormal_autophagy2.19625136
13MP0005058_abnormal_lysosome_morphology2.07156417
14MP0003300_gastrointestinal_ulcer1.97916272
15MP0003091_abnormal_cell_migration1.97457380
16MP0001545_abnormal_hematopoietic_system1.88756295
17MP0005397_hematopoietic_system_phenotyp1.88756295
18MP0004808_abnormal_hematopoietic_stem1.88350495
19MP0001849_ear_inflammation1.85908890
20MP0003724_increased_susceptibility_to1.83887495
21MP0004947_skin_inflammation1.82826930
22MP0001835_abnormal_antigen_presentation1.76797322
23MP0003279_aneurysm1.75708373
24MP0002419_abnormal_innate_immunity1.72230033
25MP0001958_emphysema1.69351402
26MP0000685_abnormal_immune_system1.63966499
27MP0001800_abnormal_humoral_immune1.61147917
28MP0003191_abnormal_cellular_cholesterol1.60850070
29MP0005025_abnormal_response_to1.59445348
30MP0002998_abnormal_bone_remodeling1.50897300
31MP0003045_fibrosis1.48700103
32MP0003566_abnormal_cell_adhesion1.47466287
33MP0004130_abnormal_muscle_cell1.41869619
34MP0002405_respiratory_system_inflammati1.39475748
35MP0003828_pulmonary_edema1.39392549
36MP0000751_myopathy1.38146323
37MP0002420_abnormal_adaptive_immunity1.38118719
38MP0002933_joint_inflammation1.37504443
39MP0001790_abnormal_immune_system1.37423262
40MP0005387_immune_system_phenotype1.37423262
41MP0002249_abnormal_larynx_morphology1.36552429
42MP0001819_abnormal_immune_cell1.36471080
43MP0004510_myositis1.36228157
44MP0001851_eye_inflammation1.33954612
45MP0002398_abnormal_bone_marrow1.32554619
46MP0005000_abnormal_immune_tolerance1.32227931
47MP0000703_abnormal_thymus_morphology1.31599832
48MP0002452_abnormal_antigen_presenting1.31410071
49MP0001533_abnormal_skeleton_physiology1.30919439
50MP0008438_abnormal_cutaneous_collagen1.30793901
51MP0000733_abnormal_muscle_development1.30446482
52MP0002009_preneoplasia1.29202330
53MP0002723_abnormal_immune_serum1.28268606
54MP0004858_abnormal_nervous_system1.27960055
55MP0005666_abnormal_adipose_tissue1.27546401
56MP0000767_abnormal_smooth_muscle1.24382963
57MP0003453_abnormal_keratinocyte_physiol1.20400584
58MP0000716_abnormal_immune_system1.19340312
59MP0004185_abnormal_adipocyte_glucose1.19040202
60MP0005375_adipose_tissue_phenotype1.15838413
61MP0002166_altered_tumor_susceptibility1.14962876
62MP0010155_abnormal_intestine_physiology1.13416187
63MP0005670_abnormal_white_adipose1.11609052
64MP0008961_abnormal_basal_metabolism1.08359630
65MP0001348_abnormal_lacrimal_gland1.06439866
66MP0002722_abnormal_immune_system1.04871331
67MP0001873_stomach_inflammation1.03721873
68MP0004883_abnormal_blood_vessel1.03019182
69MP0002332_abnormal_exercise_endurance0.99214396
70MP0003866_abnormal_defecation0.98885168
71MP0000759_abnormal_skeletal_muscle0.98585518
72MP0005503_abnormal_tendon_morphology0.98583031
73MP0002429_abnormal_blood_cell0.97048892
74MP0002108_abnormal_muscle_morphology0.96884795
75MP0000003_abnormal_adipose_tissue0.96103220
76MP0006138_congestive_heart_failure0.95845654
77MP0000858_altered_metastatic_potential0.95514948
78MP0005464_abnormal_platelet_physiology0.93573277
79MP0005621_abnormal_cell_physiology0.93245532
80MP0010630_abnormal_cardiac_muscle0.92510040
81MP0009333_abnormal_splenocyte_physiolog0.92272701
82MP0003690_abnormal_glial_cell0.91858391
83MP0005023_abnormal_wound_healing0.91420849
84MP0003656_abnormal_erythrocyte_physiolo0.89570129
85MP0009115_abnormal_fat_cell0.89460476
86MP0010368_abnormal_lymphatic_system0.89167297
87MP0003183_abnormal_peptide_metabolism0.89145141
88MP0000689_abnormal_spleen_morphology0.88434664
89MP0004087_abnormal_muscle_fiber0.87868648
90MP0000249_abnormal_blood_vessel0.84137252
91MP0005390_skeleton_phenotype0.84088300
92MP0004036_abnormal_muscle_relaxation0.81661711
93MP0004233_abnormal_muscle_weight0.81521020
94MP0008004_abnormal_stomach_pH0.80283310
95MP0002060_abnormal_skin_morphology0.78562195
96MP0002132_abnormal_respiratory_system0.75666779
97MP0005310_abnormal_salivary_gland0.75448977
98MP0005164_abnormal_response_to0.75332844
99MP0009785_altered_susceptibility_to0.73994977
100MP0000747_muscle_weakness0.73848594

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)3.94722307
2Obstructive sleep apnea (HP:0002870)3.85219017
3Broad face (HP:0000283)3.70230857
4Cerebral aneurysm (HP:0004944)3.09930601
5Eczematoid dermatitis (HP:0000976)3.01958630
6Colitis (HP:0002583)2.91992513
7Hyperacusis (HP:0010780)2.60175233
8Aortic aneurysm (HP:0004942)2.59094687
9Increased connective tissue (HP:0009025)2.56993510
10Thin bony cortex (HP:0002753)2.49337898
11Cellulitis (HP:0100658)2.35339347
12Abnormality of the columella (HP:0009929)2.34267317
13Long eyelashes (HP:0000527)2.32065985
14Dislocated radial head (HP:0003083)2.31777317
15Aneurysm (HP:0002617)2.31129912
16Increased variability in muscle fiber diameter (HP:0003557)2.30261056
17Spontaneous hematomas (HP:0007420)2.28622873
18Gastrointestinal inflammation (HP:0004386)2.28046232
19Hemorrhage of the eye (HP:0011885)2.25367461
20Cervical subluxation (HP:0003308)2.24687061
21Spinal cord lesions (HP:0100561)2.24060748
22Syringomyelia (HP:0003396)2.24060748
23Inflammation of the large intestine (HP:0002037)2.21182085
24Gingivitis (HP:0000230)2.20360055
25Increased IgE level (HP:0003212)2.19137161
26Abnormality of the radial head (HP:0003995)2.17155305
27Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.11128213
28Ulnar bowing (HP:0003031)2.09547287
29Persistence of primary teeth (HP:0006335)2.05999423
30Dysmetric saccades (HP:0000641)2.05199362
31Myositis (HP:0100614)2.05087370
32Metaphyseal cupping (HP:0003021)2.04887705
33Recurrent fungal infections (HP:0002841)1.99637359
34Distal lower limb amyotrophy (HP:0008944)1.99451661
35Narrow palate (HP:0000189)1.99392103
36Abnormality of the thoracic spine (HP:0100711)1.98389190
37Abnormality of skeletal muscle fiber size (HP:0012084)1.97914801
38Centrally nucleated skeletal muscle fibers (HP:0003687)1.97344270
39Shallow orbits (HP:0000586)1.97121412
40Asymmetric septal hypertrophy (HP:0001670)1.94910759
41Protrusio acetabuli (HP:0003179)1.94258884
42Dilatation of the ascending aorta (HP:0005111)1.92442305
43Exercise-induced myalgia (HP:0003738)1.92212545
44Aortic regurgitation (HP:0001659)1.89065748
45Slow saccadic eye movements (HP:0000514)1.88824585
46Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.88817547
47Genetic anticipation (HP:0003743)1.87688435
48Thoracic kyphosis (HP:0002942)1.86436003
49Recurrent abscess formation (HP:0002722)1.84186947
50Abnormal delayed hypersensitivity skin test (HP:0002963)1.82480901
51Flat acetabular roof (HP:0003180)1.82236457
52Recurrent bacterial skin infections (HP:0005406)1.82078427
53Abnormality of the distal phalanx of the thumb (HP:0009617)1.81968226
54Mitral valve prolapse (HP:0001634)1.80981908
55Difficulty running (HP:0009046)1.80743524
56Disproportionate tall stature (HP:0001519)1.79426982
57Gastrointestinal infarctions (HP:0005244)1.79289763
58Sparse lateral eyebrow (HP:0005338)1.78986254
59Prolonged bleeding time (HP:0003010)1.77584322
60Interstitial pulmonary disease (HP:0006530)1.76114714
61Urethral obstruction (HP:0000796)1.75816679
62Dysostosis multiplex (HP:0000943)1.75600154
63Urinary glycosaminoglycan excretion (HP:0003541)1.75244118
64Mucopolysacchariduria (HP:0008155)1.75244118
65Recurrent viral infections (HP:0004429)1.72278755
66Spondylolisthesis (HP:0003302)1.71251022
67Emphysema (HP:0002097)1.71179347
68Easy fatigability (HP:0003388)1.71176649
69Aortic dissection (HP:0002647)1.70759918
70Mitral regurgitation (HP:0001653)1.70679241
71Hyporeflexia of lower limbs (HP:0002600)1.70486699
72Peritonitis (HP:0002586)1.69442386
73Abnormality of mucopolysaccharide metabolism (HP:0011020)1.67867808
74Abnormality of polysaccharide metabolism (HP:0011012)1.67867808
75Abnormality of glycosaminoglycan metabolism (HP:0004371)1.67867808
76Recurrent gram-negative bacterial infections (HP:0005420)1.67200422
77Orchitis (HP:0100796)1.66572475
78Onion bulb formation (HP:0003383)1.66433733
79Chest pain (HP:0100749)1.65449947
80Epistaxis (HP:0000421)1.65241399
81Neoplasm of the heart (HP:0100544)1.65181574
82Chronic mucocutaneous candidiasis (HP:0002728)1.65099888
83Recurrent cutaneous fungal infections (HP:0011370)1.65099888
84Difficulty climbing stairs (HP:0003551)1.62501855
85Meningitis (HP:0001287)1.61858619
86Germ cell neoplasia (HP:0100728)1.60123146
87Neonatal hypoglycemia (HP:0001998)1.58984374
88Annular pancreas (HP:0001734)1.58368691
89Acute lymphatic leukemia (HP:0006721)1.57301471
90Pustule (HP:0200039)1.57062415
91Granulocytopenia (HP:0001913)1.56980763
92Ureteral stenosis (HP:0000071)1.55456413
93Long palpebral fissure (HP:0000637)1.55439606
94Pointed chin (HP:0000307)1.54701076
95Viral hepatitis (HP:0006562)1.53978935
96Lymphangioma (HP:0100764)1.52732464
97Joint stiffness (HP:0001387)1.52354988
98Abnormality of macrophages (HP:0004311)1.52335312
99Joint laxity (HP:0001388)1.51371579
100Deformed sella turcica (HP:0002681)1.51216837

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.41281660
2PRPF4B3.09514721
3CDK122.95899631
4ERN12.83469759
5SIK12.64610479
6ICK2.59552778
7EEF2K2.20871225
8MAP2K32.13414723
9MAP4K12.11921573
10TTN2.03401809
11TNK21.93554180
12BLK1.84415506
13SMG11.84329783
14MARK21.75551723
15RIPK11.75349439
16FGFR41.67100379
17RIPK41.66256573
18CDC42BPA1.64495207
19PKN21.60836799
20MAP3K101.60597321
21TYK21.58908918
22MAP3K71.57337068
23MAP3K131.57234501
24EPHB11.45598401
25ZAP701.43286222
26MTOR1.33116899
27MAP3K61.30253988
28PRKD21.27989965
29SIK21.27859156
30BTK1.16696956
31PDGFRA1.09952839
32JAK31.04255820
33JAK11.03928358
34MAP3K141.02930597
35FES1.00348765
36FGFR30.99299409
37RPS6KA20.98311972
38GRK60.98205000
39CAMK1D0.97058728
40MAPK70.95666984
41RPS6KC10.95555625
42RPS6KL10.95555625
43HIPK20.95219513
44TAOK10.94570303
45TBK10.94430355
46PTK60.94322210
47MAPK120.93722625
48MAP3K10.93497111
49CSK0.92261019
50MAP3K30.90725670
51MAPK150.90359108
52RET0.90291476
53MAPK110.90064163
54HCK0.89015816
55STK380.88242923
56KIT0.87719205
57IRAK40.84283228
58RPS6KA60.79279080
59IKBKE0.78614681
60TRPM70.72728901
61BRD40.72043800
62PDGFRB0.71632136
63SGK30.71353490
64PDPK10.70857877
65AKT30.70591068
66CDK40.67843784
67MARK30.66330043
68BMX0.65004597
69IRAK20.64341811
70SYK0.63420849
71CSF1R0.62094751
72CAMKK10.60558688
73IRAK30.60131066
74JAK20.59933549
75PDK10.59097164
76CHUK0.57585407
77SIK30.56914401
78MST1R0.56854698
79LCK0.55113221
80KSR20.53695155
81CAMK1G0.53603519
82EPHA30.51280730
83MELK0.50852696
84SGK20.50057269
85ITK0.49965882
86TGFBR20.49416870
87MAP3K110.48860602
88PTK2B0.48468034
89PRKAA20.47896415
90WNK10.47509295
91MAP2K60.46803571
92MAPK40.46506413
93TAOK20.44814146
94CAMK40.42599388
95NLK0.42465726
96MAP2K20.42400255
97MAPK80.41321693
98PRKCH0.41236862
99PRKD10.39682037
100ERBB20.39378392

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.20427080
2Acute myeloid leukemia_Homo sapiens_hsa052212.10573041
3Notch signaling pathway_Homo sapiens_hsa043302.06863853
4B cell receptor signaling pathway_Homo sapiens_hsa046621.80850792
5Non-small cell lung cancer_Homo sapiens_hsa052231.76736672
6Osteoclast differentiation_Homo sapiens_hsa043801.72190256
7Chronic myeloid leukemia_Homo sapiens_hsa052201.71044846
8Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.56745735
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.54515656
10VEGF signaling pathway_Homo sapiens_hsa043701.53314718
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.49932977
12mTOR signaling pathway_Homo sapiens_hsa041501.43830798
13Leishmaniasis_Homo sapiens_hsa051401.37623399
14AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.36676557
15Pancreatic cancer_Homo sapiens_hsa052121.33460659
16Phospholipase D signaling pathway_Homo sapiens_hsa040721.31298028
17Phosphatidylinositol signaling system_Homo sapiens_hsa040701.31248834
18Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.30563332
19Endometrial cancer_Homo sapiens_hsa052131.28121568
20Neurotrophin signaling pathway_Homo sapiens_hsa047221.26712322
21T cell receptor signaling pathway_Homo sapiens_hsa046601.25461204
22Platelet activation_Homo sapiens_hsa046111.24167707
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.22422121
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.22230532
25Choline metabolism in cancer_Homo sapiens_hsa052311.22145513
26GnRH signaling pathway_Homo sapiens_hsa049121.19934615
27Lysine degradation_Homo sapiens_hsa003101.18544996
28Longevity regulating pathway - mammal_Homo sapiens_hsa042111.17971696
29TNF signaling pathway_Homo sapiens_hsa046681.16004288
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.15593745
31Hepatitis B_Homo sapiens_hsa051611.14686612
32Renal cell carcinoma_Homo sapiens_hsa052111.14638854
33Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14463075
34Toxoplasmosis_Homo sapiens_hsa051451.13290366
35Prolactin signaling pathway_Homo sapiens_hsa049171.12997454
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.11512708
37Insulin resistance_Homo sapiens_hsa049311.08242068
38Influenza A_Homo sapiens_hsa051641.06910121
39Glioma_Homo sapiens_hsa052141.04868069
40Focal adhesion_Homo sapiens_hsa045101.04675088
41Hepatitis C_Homo sapiens_hsa051601.04596244
42Inositol phosphate metabolism_Homo sapiens_hsa005621.04502208
43Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.03519112
44Staphylococcus aureus infection_Homo sapiens_hsa051501.01658805
45ErbB signaling pathway_Homo sapiens_hsa040121.01184356
46Malaria_Homo sapiens_hsa051440.99487032
47Insulin signaling pathway_Homo sapiens_hsa049100.99400446
48Tuberculosis_Homo sapiens_hsa051520.98548384
49Adipocytokine signaling pathway_Homo sapiens_hsa049200.98420563
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96511825
51Measles_Homo sapiens_hsa051620.96506583
52Jak-STAT signaling pathway_Homo sapiens_hsa046300.95792140
53Prostate cancer_Homo sapiens_hsa052150.95581908
54Estrogen signaling pathway_Homo sapiens_hsa049150.94906049
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.94326273
56Dorso-ventral axis formation_Homo sapiens_hsa043200.93858787
57FoxO signaling pathway_Homo sapiens_hsa040680.92274561
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92025431
59Chemokine signaling pathway_Homo sapiens_hsa040620.90957868
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89872743
61MicroRNAs in cancer_Homo sapiens_hsa052060.89551277
62Amoebiasis_Homo sapiens_hsa051460.87429499
63Colorectal cancer_Homo sapiens_hsa052100.86900482
64Small cell lung cancer_Homo sapiens_hsa052220.86827245
65Bladder cancer_Homo sapiens_hsa052190.85597020
66Aldosterone synthesis and secretion_Homo sapiens_hsa049250.81606973
67AMPK signaling pathway_Homo sapiens_hsa041520.81287073
68Herpes simplex infection_Homo sapiens_hsa051680.80478665
69Type II diabetes mellitus_Homo sapiens_hsa049300.80361382
70Apoptosis_Homo sapiens_hsa042100.78762067
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.76872128
72HTLV-I infection_Homo sapiens_hsa051660.75027063
73Primary immunodeficiency_Homo sapiens_hsa053400.75014617
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73567752
75Proteoglycans in cancer_Homo sapiens_hsa052050.72925872
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72496395
77MAPK signaling pathway_Homo sapiens_hsa040100.72063620
78Thyroid cancer_Homo sapiens_hsa052160.70676234
79Long-term potentiation_Homo sapiens_hsa047200.69720816
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69445108
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.68763862
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68359674
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64210438
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.64093180
85ABC transporters_Homo sapiens_hsa020100.62397115
86Viral myocarditis_Homo sapiens_hsa054160.62365808
87Rap1 signaling pathway_Homo sapiens_hsa040150.62321817
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61897051
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60605619
90Oxytocin signaling pathway_Homo sapiens_hsa049210.60530723
91Pertussis_Homo sapiens_hsa051330.60303955
92ECM-receptor interaction_Homo sapiens_hsa045120.59950722
93HIF-1 signaling pathway_Homo sapiens_hsa040660.58269299
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58178912
95Hematopoietic cell lineage_Homo sapiens_hsa046400.57470447
96Endocytosis_Homo sapiens_hsa041440.57068492
97Viral carcinogenesis_Homo sapiens_hsa052030.56996655
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.56142450
99Dilated cardiomyopathy_Homo sapiens_hsa054140.54128220
100Cholinergic synapse_Homo sapiens_hsa047250.53878731

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