ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	GDP-mannose metabolic process (GO:0019673)	6.20433314
2	cellular response to ATP (GO:0071318)	5.98240455
3	meiotic chromosome segregation (GO:0045132)	5.64722855
4	positive regulation of catecholamine secretion (GO:0033605)	5.45488681
5	negative regulation of cell aging (GO:0090344)	5.36221982
6	DNA strand renaturation (GO:0000733)	5.34708558
7	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	5.29835897
8	adenosine receptor signaling pathway (GO:0001973)	5.27634309
9	positive regulation of protein kinase C signaling (GO:0090037)	5.16718490
10	purinergic nucleotide receptor signaling pathway (GO:0035590)	4.40367127
11	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	4.38046646
12	regulation of skeletal muscle contraction (GO:0014819)	4.35973590
13	adenine nucleotide transport (GO:0051503)	4.32609970
14	purine ribonucleotide transport (GO:0015868)	4.17526968
15	rRNA methylation (GO:0031167)	4.15672600
16	mannose metabolic process (GO:0006013)	4.07470791
17	sensory perception of taste (GO:0050909)	4.00497777
18	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.76606058
19	histone H3-K36 demethylation (GO:0070544)	3.71824751
20	regulation of monocyte differentiation (GO:0045655)	3.69515981
21	melanin metabolic process (GO:0006582)	3.61168925
22	melanin biosynthetic process (GO:0042438)	3.51950851
23	histone phosphorylation (GO:0016572)	3.50027267
24	response to ATP (GO:0033198)	3.45469550
25	UV protection (GO:0009650)	3.43816975
26	gonadal mesoderm development (GO:0007506)	3.42567870
27	3-UTR-mediated mRNA stabilization (GO:0070935)	3.36386515
28	G-protein coupled purinergic receptor signaling pathway (GO:0035588)	3.34186731
29	positive regulation of odontogenesis (GO:0042482)	3.34120907
30	purinergic receptor signaling pathway (GO:0035587)	3.32301542
31	lens fiber cell differentiation (GO:0070306)	3.25784256
32	negative regulation of erythrocyte differentiation (GO:0045647)	3.24411050
33	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	3.23245479
34	urinary tract smooth muscle contraction (GO:0014848)	3.20827981
35	mRNA cleavage (GO:0006379)	3.20651201
36	germ cell migration (GO:0008354)	3.17016588
37	purine nucleotide transport (GO:0015865)	3.16962961
38	sex determination (GO:0007530)	3.13115736
39	rRNA modification (GO:0000154)	3.12868598
40	peptidyl-glutamic acid carboxylation (GO:0017187)	3.12676219
41	protein carboxylation (GO:0018214)	3.12676219
42	regulation of NFAT protein import into nucleus (GO:0051532)	3.11775584
43	snRNA metabolic process (GO:0016073)	3.04671750
44	actin nucleation (GO:0045010)	3.04530439
45	cellular response to virus (GO:0098586)	3.03073011
46	oligosaccharide catabolic process (GO:0009313)	3.02479222
47	mitochondrion distribution (GO:0048311)	2.98860097
48	mitotic chromosome condensation (GO:0007076)	2.97040084
49	positive regulation of gamma-delta T cell activation (GO:0046645)	2.97019992
50	DNA duplex unwinding (GO:0032508)	2.93842239
51	nucleoside transmembrane transport (GO:1901642)	2.92674706
52	regulation of protein kinase A signaling (GO:0010738)	2.91764663
53	regulation of type I interferon-mediated signaling pathway (GO:0060338)	2.88149526
54	positive thymic T cell selection (GO:0045059)	2.87784805
55	phenylpropanoid metabolic process (GO:0009698)	2.86438433
56	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	2.84171396
57	nucleoside bisphosphate biosynthetic process (GO:0033866)	2.84171396
58	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	2.84171396
59	chromatin silencing (GO:0006342)	2.82330128
60	peristalsis (GO:0030432)	2.82287182
61	stress granule assembly (GO:0034063)	2.80455012
62	thymic T cell selection (GO:0045061)	2.80276907
63	snRNA processing (GO:0016180)	2.78150439
64	mRNA stabilization (GO:0048255)	2.78045630
65	RNA stabilization (GO:0043489)	2.78045630
66	granulocyte differentiation (GO:0030851)	2.72820409
67	DNA geometric change (GO:0032392)	2.72081151
68	regulation of cytokine production involved in inflammatory response (GO:1900015)	2.71938248
69	DNA replication checkpoint (GO:0000076)	2.68221930
70	folic acid metabolic process (GO:0046655)	2.67273102
71	regulation of histone H3-K27 methylation (GO:0061085)	2.66227312
72	modulation by virus of host process (GO:0019054)	2.61819259
73	peptidyl-threonine phosphorylation (GO:0018107)	2.58148991
74	peptidyl-threonine modification (GO:0018210)	2.55543843
75	planar cell polarity pathway involved in neural tube closure (GO:0090179)	2.53700842
76	embryonic process involved in female pregnancy (GO:0060136)	2.53269808
77	regulation of ARF GTPase activity (GO:0032312)	2.53008561
78	positive regulation of transcription from RNA polymerase III promoter (GO:0045945)	2.52669022
79	trophectodermal cell differentiation (GO:0001829)	2.51898636
80	protein retention in ER lumen (GO:0006621)	2.49264163
81	regulation of gamma-delta T cell differentiation (GO:0045586)	2.49071626
82	histone lysine methylation (GO:0034968)	2.48720482
83	histone H3-K9 modification (GO:0061647)	2.48583019
84	regulation of DNA damage checkpoint (GO:2000001)	2.48441916
85	positive regulation of CREB transcription factor activity (GO:0032793)	2.48408806
86	negative regulation of gene expression, epigenetic (GO:0045814)	2.48407975
87	negative regulation of interleukin-8 production (GO:0032717)	2.48319863
88	secondary metabolite biosynthetic process (GO:0044550)	2.48039222
89	regulation of chromatin binding (GO:0035561)	2.46608200
90	convergent extension (GO:0060026)	2.45276114
91	histone H3-K9 methylation (GO:0051567)	2.42161120
92	retrograde transport, endosome to Golgi (GO:0042147)	2.41653588
93	nucleotide transmembrane transport (GO:1901679)	2.40032751
94	histone H4 deacetylation (GO:0070933)	2.37855678
95	anatomical structure regression (GO:0060033)	2.36800538
96	nucleoside transport (GO:0015858)	2.36794879
97	cell migration in hindbrain (GO:0021535)	2.36647456
98	nucleotide-sugar biosynthetic process (GO:0009226)	2.35992183
99	regulation of glycogen (starch) synthase activity (GO:2000465)	2.35942901
100	regulation of cell aging (GO:0090342)	2.35324122

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_21846776_ChIP-Seq_THP-1_Human	4.70454628
2	STAT6_21828071_ChIP-Seq_BEAS2B_Human	4.03922228
3	MYC_22102868_ChIP-Seq_BL_Human	3.56954263
4	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	3.01306597
5	LXR_22292898_ChIP-Seq_THP-1_Human	2.93864345
6	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.74607537
7	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	2.65436958
8	E2F7_22180533_ChIP-Seq_HELA_Human	2.63021070
9	MAF_26560356_Chip-Seq_TH2_Human	2.60407547
10	VDR_24763502_ChIP-Seq_THP-1_Human	2.58897126
11	KDM2B_26808549_Chip-Seq_SUP-B15_Human	2.52193373
12	P68_20966046_ChIP-Seq_HELA_Human	2.51932503
13	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.47315121
14	MAF_26560356_Chip-Seq_TH1_Human	2.43744238
15	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.28968397
16	KDM2B_26808549_Chip-Seq_DND41_Human	2.24152576
17	TCF7_22412390_ChIP-Seq_EML_Mouse	2.17860678
18	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	2.11346987
19	ELK3_25401928_ChIP-Seq_HUVEC_Human	2.06024792
20	RACK7_27058665_Chip-Seq_MCF-7_Human	2.04941693
21	UTX_26944678_Chip-Seq_JUKART_Human	2.04651060
22	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.00258540
23	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.97423377
24	BCL6_27268052_Chip-Seq_Bcells_Human	1.96532375
25	XRN2_22483619_ChIP-Seq_HELA_Human	1.92490367
26	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.91693103
27	BCOR_27268052_Chip-Seq_Bcells_Human	1.90394567
28	SMC4_20622854_ChIP-Seq_HELA_Human	1.87438754
29	CTCF_27219007_Chip-Seq_Bcells_Human	1.76792409
30	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.72524570
31	E2F1_20622854_ChIP-Seq_HELA_Human	1.70157596
32	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.69389190
33	PHF8_20622854_ChIP-Seq_HELA_Human	1.67853743
34	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.67536304
35	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.62012520
36	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.61664329
37	CREB1_26743006_Chip-Seq_LNCaP_Human	1.56109955
38	CTCF_21964334_Chip-Seq_Bcells_Human	1.54019820
39	SCL_19346495_ChIP-Seq_HPC-7_Human	1.53408502
40	NCOR1_26117541_ChIP-Seq_K562_Human	1.53225056
41	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.52453209
42	KDM2B_26808549_Chip-Seq_K562_Human	1.46616838
43	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.46046469
44	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.45004921
45	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.42927637
46	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.39432967
47	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.39367555
48	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.37875199
49	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.37652219
50	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.36922778
51	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.35191988
52	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.30437775
53	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.28694932
54	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.27830513
55	TP53_22127205_ChIP-Seq_IMR90_Human	1.26911751
56	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.24585045
57	ETS1_21867929_ChIP-Seq_TH2_Mouse	1.23871571
58	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.22939780
59	CIITA_25753668_ChIP-Seq_RAJI_Human	1.21918320
60	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.21397338
61	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.21275286
62	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.20803254
63	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.20707565
64	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.19778374
65	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.17992099
66	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.16722255
67	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.16018884
68	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.15793911
69	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.15778820
70	SA1_27219007_Chip-Seq_Bcells_Human	1.15770238
71	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.14878556
72	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.14072678
73	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.13321422
74	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.12574428
75	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.12535330
76	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.12283432
77	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.10277069
78	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.09865398
79	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.08900584
80	CTCF_20526341_ChIP-Seq_ESCs_Human	1.07949047
81	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.07027171
82	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.06348498
83	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	1.05733215
84	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.04932559
85	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.04750694
86	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.03574891
87	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.02099113
88	TP63_22573176_ChIP-Seq_HFKS_Human	1.01856474
89	P300_27268052_Chip-Seq_Bcells_Human	1.01855072
90	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.00207358
91	ATF3_27146783_Chip-Seq_COLON_Human	0.99997063
92	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.99988031
93	GATA1_19941826_ChIP-Seq_K562_Human	0.98355252
94	EGR1_19374776_ChIP-ChIP_THP-1_Human	0.97744049
95	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.97646044
96	MYB_26560356_Chip-Seq_TH1_Human	0.97295197
97	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.97255334
98	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.97033132
99	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.96766379
100	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.96668091

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005171_absent_coat_pigmentation	5.78506249
2	MP0005174_abnormal_tail_pigmentation	5.13953644
3	MP0003136_yellow_coat_color	5.10322509
4	MP0001986_abnormal_taste_sensitivity	4.48341063
5	MP0009278_abnormal_bone_marrow	4.22736640
6	MP0005423_abnormal_somatic_nervous	3.91823340
7	MP0005409_darkened_coat_color	3.17106726
8	MP0004381_abnormal_hair_follicle	2.72702830
9	MP0000015_abnormal_ear_pigmentation	2.66890984
10	MP0005076_abnormal_cell_differentiation	2.43877140
11	MP0003705_abnormal_hypodermis_morpholog	2.32430742
12	MP0003111_abnormal_nucleus_morphology	2.17965907
13	MP0004808_abnormal_hematopoietic_stem	2.08761582
14	MP0003091_abnormal_cell_migration	1.99582151
15	MP0003693_abnormal_embryo_hatching	1.91852817
16	MP0005083_abnormal_biliary_tract	1.90202583
17	MP0003329_amyloid_beta_deposits	1.87120075
18	MP0001188_hyperpigmentation	1.82316527
19	MP0005397_hematopoietic_system_phenotyp	1.76266675
20	MP0001545_abnormal_hematopoietic_system	1.76266675
21	MP0003763_abnormal_thymus_physiology	1.70596475
22	MP0001873_stomach_inflammation	1.61501093
23	MP0004858_abnormal_nervous_system	1.61394257
24	MP0001502_abnormal_circadian_rhythm	1.60329507
25	MP0000751_myopathy	1.57293248
26	MP0001661_extended_life_span	1.56622304
27	MP0003453_abnormal_keratinocyte_physiol	1.50773530
28	MP0005058_abnormal_lysosome_morphology	1.43453635
29	MP0005451_abnormal_body_composition	1.40236221
30	MP0010094_abnormal_chromosome_stability	1.34723573
31	MP0002638_abnormal_pupillary_reflex	1.34581742
32	MP0003077_abnormal_cell_cycle	1.32482269
33	MP0001968_abnormal_touch/_nociception	1.32255143
34	MP0004130_abnormal_muscle_cell	1.25007536
35	MP0003303_peritoneal_inflammation	1.23799297
36	MP0002009_preneoplasia	1.22137880
37	MP0000538_abnormal_urinary_bladder	1.19991714
38	MP0004947_skin_inflammation	1.14722796
39	MP0000703_abnormal_thymus_morphology	1.13992322
40	MP0003632_abnormal_nervous_system	1.12601962
41	MP0002398_abnormal_bone_marrow	1.09744398
42	MP0001756_abnormal_urination	1.07282089
43	MP0002405_respiratory_system_inflammati	1.06806458
44	MP0000003_abnormal_adipose_tissue	1.04655757
45	MP0009333_abnormal_splenocyte_physiolog	1.02956475
46	MP0004957_abnormal_blastocyst_morpholog	1.02670665
47	MP0000685_abnormal_immune_system	1.00591529
48	MP0002249_abnormal_larynx_morphology	0.99686254
49	MP0000604_amyloidosis	0.95427214
50	MP0002722_abnormal_immune_system	0.94582743
51	MP0002396_abnormal_hematopoietic_system	0.93177223
52	MP0003172_abnormal_lysosome_physiology	0.92794611
53	MP0000689_abnormal_spleen_morphology	0.90052025
54	MP0002933_joint_inflammation	0.86477919
55	MP0008057_abnormal_DNA_replication	0.83902315
56	MP0001958_emphysema	0.81049347
57	MP0002429_abnormal_blood_cell	0.80834476
58	MP0005220_abnormal_exocrine_pancreas	0.80512999
59	MP0005621_abnormal_cell_physiology	0.79304093
60	MP0000371_diluted_coat_color	0.79147965
61	MP0000716_abnormal_immune_system	0.78909264
62	MP0002019_abnormal_tumor_incidence	0.78380764
63	MP0004782_abnormal_surfactant_physiolog	0.76307507
64	MP0005410_abnormal_fertilization	0.74694404
65	MP0004233_abnormal_muscle_weight	0.74490277
66	MP0000750_abnormal_muscle_regeneration	0.74273229
67	MP0005584_abnormal_enzyme/coenzyme_acti	0.73638549
68	MP0001849_ear_inflammation	0.73060681
69	MP0002075_abnormal_coat/hair_pigmentati	0.72771945
70	MP0002452_abnormal_antigen_presenting	0.70773737
71	MP0001800_abnormal_humoral_immune	0.70306987
72	MP0009931_abnormal_skin_appearance	0.69090348
73	MP0008260_abnormal_autophagy	0.67363795
74	MP0002420_abnormal_adaptive_immunity	0.66664384
75	MP0000747_muscle_weakness	0.66384993
76	MP0003984_embryonic_growth_retardation	0.65830987
77	MP0001765_abnormal_ion_homeostasis	0.65766739
78	MP0001919_abnormal_reproductive_system	0.65689487
79	MP0001819_abnormal_immune_cell	0.65147948
80	MP0002877_abnormal_melanocyte_morpholog	0.63449101
81	MP0002723_abnormal_immune_serum	0.63233266
82	MP0002086_abnormal_extraembryonic_tissu	0.62284643
83	MP0002080_prenatal_lethality	0.61802637
84	MP0009840_abnormal_foam_cell	0.61445354
85	MP0005380_embryogenesis_phenotype	0.60447745
86	MP0001672_abnormal_embryogenesis/_devel	0.60447745
87	MP0002088_abnormal_embryonic_growth/wei	0.60426330
88	MP0000013_abnormal_adipose_tissue	0.57872536
89	MP0000490_abnormal_crypts_of	0.57770186
90	MP0005025_abnormal_response_to	0.57080465
91	MP0003959_abnormal_lean_body	0.56845100
92	MP0003436_decreased_susceptibility_to	0.56328606
93	MP0001835_abnormal_antigen_presentation	0.55869000
94	MP0004197_abnormal_fetal_growth/weight/	0.55570570
95	MP0008961_abnormal_basal_metabolism	0.55232680
96	MP0001348_abnormal_lacrimal_gland	0.54184877
97	MP0003448_altered_tumor_morphology	0.54090431
98	MP0001790_abnormal_immune_system	0.53556022
99	MP0005387_immune_system_phenotype	0.53556022
100	MP0000350_abnormal_cell_proliferation	0.53485106

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Annular pancreas (HP:0001734)	5.36201493
2	Ulnar bowing (HP:0003031)	5.18329567
3	Rib fusion (HP:0000902)	4.89623004
4	Intestinal fistula (HP:0100819)	4.76231767
5	Testicular atrophy (HP:0000029)	4.56554568
6	Facial hemangioma (HP:0000329)	4.40597130
7	Turricephaly (HP:0000262)	4.36285093
8	Rectovaginal fistula (HP:0000143)	4.34638849
9	Rectal fistula (HP:0100590)	4.34638849
10	Congenital stationary night blindness (HP:0007642)	4.29034057
11	Thin bony cortex (HP:0002753)	4.24326616
12	Poikiloderma (HP:0001029)	4.23274229
13	Vaginal fistula (HP:0004320)	4.20806525
14	Anteriorly placed anus (HP:0001545)	3.66477094
15	Attenuation of retinal blood vessels (HP:0007843)	3.53000738
16	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	3.26915423
17	Hemorrhage of the eye (HP:0011885)	3.17506677
18	Squamous cell carcinoma (HP:0002860)	3.14906149
19	Abnormality of the intrinsic pathway (HP:0010989)	3.08663758
20	Popliteal pterygium (HP:0009756)	3.06011679
21	Dyschromatopsia (HP:0007641)	3.04495563
22	Coronal craniosynostosis (HP:0004440)	2.97800018
23	Facial diplegia (HP:0001349)	2.97609999
24	Patellar aplasia (HP:0006443)	2.92109806
25	Akinesia (HP:0002304)	2.88059559
26	Capillary hemangiomas (HP:0005306)	2.80881115
27	Abnormality of the fingertips (HP:0001211)	2.73326204
28	Aplasia/Hypoplasia of the patella (HP:0006498)	2.66729367
29	Bony spicule pigmentary retinopathy (HP:0007737)	2.64284593
30	Aplasia of the musculature (HP:0100854)	2.63039876
31	Delayed epiphyseal ossification (HP:0002663)	2.62541108
32	Birth length less than 3rd percentile (HP:0003561)	2.61773393
33	Widely patent fontanelles and sutures (HP:0004492)	2.59934226
34	Premature graying of hair (HP:0002216)	2.56922727
35	Absent thumb (HP:0009777)	2.55652119
36	Breast hypoplasia (HP:0003187)	2.55224154
37	Bowed forearm bones (HP:0003956)	2.50978420
38	Bowing of the arm (HP:0006488)	2.50978420
39	Absent radius (HP:0003974)	2.50785666
40	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.49334236
41	Short chin (HP:0000331)	2.49314271
42	Abnormality of the costochondral junction (HP:0000919)	2.45155780
43	Joint stiffness (HP:0001387)	2.44364766
44	Thin ribs (HP:0000883)	2.38266662
45	Short humerus (HP:0005792)	2.34145214
46	Increased number of teeth (HP:0011069)	2.29241471
47	Basal cell carcinoma (HP:0002671)	2.28066384
48	Absent forearm bone (HP:0003953)	2.27728215
49	Aplasia involving forearm bones (HP:0009822)	2.27728215
50	Mesangial abnormality (HP:0001966)	2.24866207
51	Broad face (HP:0000283)	2.20999095
52	Global brain atrophy (HP:0002283)	2.20375562
53	Neonatal respiratory distress (HP:0002643)	2.19416405
54	Impaired smooth pursuit (HP:0007772)	2.14557048
55	Chronic mucocutaneous candidiasis (HP:0002728)	2.14009206
56	Recurrent cutaneous fungal infections (HP:0011370)	2.14009206
57	Prominent nose (HP:0000448)	2.13381444
58	Male infertility (HP:0003251)	2.12666308
59	Flat occiput (HP:0005469)	2.08172132
60	Short thumb (HP:0009778)	2.07048731
61	Aplasia/hypoplasia of the humerus (HP:0006507)	2.06187278
62	Spina bifida occulta (HP:0003298)	2.03110371
63	Colitis (HP:0002583)	1.99858494
64	Fetal akinesia sequence (HP:0001989)	1.99743537
65	Abnormality of pyrimidine metabolism (HP:0004353)	1.99064343
66	Duplicated collecting system (HP:0000081)	1.98470211
67	Vertebral clefting (HP:0008428)	1.97611117
68	Chromsome breakage (HP:0040012)	1.93397155
69	Genu recurvatum (HP:0002816)	1.92778245
70	Abnormality of saccadic eye movements (HP:0000570)	1.90716184
71	Ectopic kidney (HP:0000086)	1.90609258
72	Arterial tortuosity (HP:0005116)	1.90147716
73	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	1.87458223
74	Dislocated radial head (HP:0003083)	1.87325688
75	Joint hemorrhage (HP:0005261)	1.87099469
76	Enlarged epiphyses (HP:0010580)	1.86780487
77	Pustule (HP:0200039)	1.85306826
78	Atrioventricular block (HP:0001678)	1.85142928
79	Hyperacusis (HP:0010780)	1.84277945
80	Villous atrophy (HP:0011473)	1.83129135
81	Abnormality of small intestinal villus morphology (HP:0011472)	1.83129135
82	Optic nerve coloboma (HP:0000588)	1.79050634
83	Metaphyseal cupping (HP:0003021)	1.78678214
84	Broad distal phalanx of finger (HP:0009836)	1.78404485
85	Choanal stenosis (HP:0000452)	1.77789395
86	Abnormality of the columella (HP:0009929)	1.76124990
87	Wide cranial sutures (HP:0010537)	1.75803394
88	Abnormality of the renal collecting system (HP:0004742)	1.75573794
89	Abnormality of the radial head (HP:0003995)	1.74037489
90	Pendular nystagmus (HP:0012043)	1.73622168
91	Hypotelorism (HP:0000601)	1.71542474
92	Mucopolysacchariduria (HP:0008155)	1.69816139
93	Urinary glycosaminoglycan excretion (HP:0003541)	1.69816139
94	Chorioretinal atrophy (HP:0000533)	1.69631667
95	Cervical subluxation (HP:0003308)	1.69416746
96	Abnormality of DNA repair (HP:0003254)	1.68600764
97	Truncal obesity (HP:0001956)	1.66802791
98	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.66599308
99	Dysmetric saccades (HP:0000641)	1.65988477
100	Easy fatigability (HP:0003388)	1.65324928

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPK15	5.12435878
2	CDK12	3.75009673
3	TRIB3	3.45311606
4	ICK	2.91900958
5	ERN1	2.80557869
6	MAP3K10	2.73749999
7	TESK2	2.65213294
8	BLK	2.60561307
9	EEF2K	2.51190812
10	MAP2K3	2.38846789
11	WNK4	2.23866925
12	SMG1	2.08845991
13	PRPF4B	2.04704890
14	GRK6	1.96402739
15	SIK1	1.88987501
16	SIK2	1.81730259
17	ZAP70	1.77793789
18	MAP4K1	1.76177331
19	CDK4	1.67001445
20	TLK1	1.48867760
21	NEK2	1.46165941
22	BRD4	1.41144471
23	MTOR	1.35549311
24	WNK1	1.24663530
25	MAPK11	1.19528343
26	RPS6KC1	1.16319746
27	RPS6KL1	1.16319746
28	GRK1	1.14216788
29	KSR2	1.13861498
30	IRAK2	1.13813913
31	PRKD2	1.12450936
32	CDK6	1.11238049
33	PKN2	1.08426182
34	RPS6KA6	1.04671805
35	RAF1	1.02993889
36	TTN	1.01132633
37	RPS6KA2	0.95083796
38	PIM2	0.92832493
39	CAMK1D	0.89958068
40	MAPK12	0.89765186
41	FGFR3	0.88672266
42	MAP3K1	0.87706146
43	PDPK1	0.86237128
44	MARK2	0.80853021
45	MAP3K13	0.80604089
46	MAP3K7	0.77704274
47	TAOK2	0.77611373
48	TBK1	0.77442162
49	MAP3K14	0.76812379
50	PRKD3	0.74940446
51	LATS1	0.74116327
52	ZAK	0.73586201
53	DYRK1B	0.73426659
54	STK38	0.73266075
55	IRAK3	0.72152161
56	MELK	0.71566694
57	BTK	0.68343828
58	TGFBR1	0.66049228
59	FGFR4	0.63710414
60	MUSK	0.63670768
61	CDC42BPA	0.63614134
62	MAPK7	0.61991292
63	ATR	0.60872618
64	ADRBK2	0.59863350
65	CSK	0.57766054
66	TGFBR2	0.55601058
67	TAOK1	0.54238710
68	SYK	0.52746216
69	BMX	0.51624604
70	IKBKE	0.51475402
71	DDR2	0.51449918
72	HIPK2	0.50917461
73	CDK3	0.49246458
74	MAP3K3	0.48455912
75	MAP3K8	0.48054094
76	MAP3K11	0.48014559
77	RET	0.46320459
78	TNK2	0.46290462
79	RPS6KA1	0.45395984
80	PDGFRA	0.44530253
81	AURKA	0.44232182
82	TYRO3	0.43844828
83	CDK2	0.43685660
84	CHEK2	0.41386935
85	CDK7	0.40912126
86	JAK3	0.40008251
87	SRPK1	0.39268341
88	DYRK3	0.39011320
89	PIM1	0.38661712
90	MAP2K2	0.37914765
91	PRKD1	0.37629923
92	CHEK1	0.37262105
93	IRAK4	0.37107618
94	MAPK8	0.36323017
95	HCK	0.36266894
96	AKT2	0.36079434
97	MAPK3	0.34847429
98	RPS6KB2	0.34844742
99	PDGFRB	0.33290471
100	CDK8	0.32971987

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	5.41134902
2	Sulfur relay system_Homo sapiens_hsa04122	4.06319635
3	Cyanoamino acid metabolism_Homo sapiens_hsa00460	3.60780184
4	Other glycan degradation_Homo sapiens_hsa00511	2.77665884
5	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.61475930
6	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.29702756
7	Fructose and mannose metabolism_Homo sapiens_hsa00051	2.08682741
8	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.89068563
9	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.86221526
10	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.78665553
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.70759174
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.62365146
13	Lysine degradation_Homo sapiens_hsa00310	1.54301204
14	mTOR signaling pathway_Homo sapiens_hsa04150	1.31732175
15	Bladder cancer_Homo sapiens_hsa05219	1.29163983
16	Acute myeloid leukemia_Homo sapiens_hsa05221	1.27902872
17	Notch signaling pathway_Homo sapiens_hsa04330	1.27266809
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.26266536
19	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.26107501
20	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.25003424
21	Non-small cell lung cancer_Homo sapiens_hsa05223	1.24669178
22	Primary immunodeficiency_Homo sapiens_hsa05340	1.21258923
23	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.15926911
24	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.14840224
25	Sphingolipid metabolism_Homo sapiens_hsa00600	1.14691000
26	Taste transduction_Homo sapiens_hsa04742	1.13389076
27	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.13344147
28	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.02043491
29	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.98150048
30	Thyroid cancer_Homo sapiens_hsa05216	0.96702516
31	Cell cycle_Homo sapiens_hsa04110	0.95913095
32	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.95836595
33	Hepatitis B_Homo sapiens_hsa05161	0.94791869
34	HTLV-I infection_Homo sapiens_hsa05166	0.92524422
35	Osteoclast differentiation_Homo sapiens_hsa04380	0.92177934
36	Endometrial cancer_Homo sapiens_hsa05213	0.91500829
37	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.89737388
38	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.89262776
39	VEGF signaling pathway_Homo sapiens_hsa04370	0.88603523
40	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.88255628
41	Base excision repair_Homo sapiens_hsa03410	0.87146940
42	Pancreatic cancer_Homo sapiens_hsa05212	0.86601495
43	Apoptosis_Homo sapiens_hsa04210	0.84715659
44	Hepatitis C_Homo sapiens_hsa05160	0.80669017
45	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.80469737
46	mRNA surveillance pathway_Homo sapiens_hsa03015	0.79241356
47	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.78054086
48	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.77672834
49	MicroRNAs in cancer_Homo sapiens_hsa05206	0.75475047
50	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.73149488
51	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.72642980
52	TNF signaling pathway_Homo sapiens_hsa04668	0.72525590
53	Small cell lung cancer_Homo sapiens_hsa05222	0.71282971
54	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.70654527
55	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.69566125
56	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.67944352
57	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.64821259
58	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.63525603
59	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.62845449
60	Colorectal cancer_Homo sapiens_hsa05210	0.61635740
61	Melanogenesis_Homo sapiens_hsa04916	0.61618056
62	Basal cell carcinoma_Homo sapiens_hsa05217	0.61475999
63	Viral carcinogenesis_Homo sapiens_hsa05203	0.60952462
64	Gap junction_Homo sapiens_hsa04540	0.60895176
65	Herpes simplex infection_Homo sapiens_hsa05168	0.60865367
66	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.60349676
67	Prostate cancer_Homo sapiens_hsa05215	0.60282581
68	Influenza A_Homo sapiens_hsa05164	0.59615279
69	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.58365850
70	FoxO signaling pathway_Homo sapiens_hsa04068	0.57070740
71	DNA replication_Homo sapiens_hsa03030	0.55913112
72	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.55756843
73	Circadian rhythm_Homo sapiens_hsa04710	0.55424405
74	Lysosome_Homo sapiens_hsa04142	0.54089321
75	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.54015861
76	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.53789909
77	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.53440158
78	Hippo signaling pathway_Homo sapiens_hsa04390	0.52245118
79	Measles_Homo sapiens_hsa05162	0.51596583
80	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.51395595
81	Insulin resistance_Homo sapiens_hsa04931	0.47664497
82	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.47249426
83	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.45172668
84	Calcium signaling pathway_Homo sapiens_hsa04020	0.45029678
85	MAPK signaling pathway_Homo sapiens_hsa04010	0.43278729
86	Chemokine signaling pathway_Homo sapiens_hsa04062	0.43162889
87	GnRH signaling pathway_Homo sapiens_hsa04912	0.42752315
88	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.42185352
89	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.42128206
90	Platelet activation_Homo sapiens_hsa04611	0.41956846
91	Insulin signaling pathway_Homo sapiens_hsa04910	0.41595620
92	Endocytosis_Homo sapiens_hsa04144	0.41326612
93	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.40534052
94	Toxoplasmosis_Homo sapiens_hsa05145	0.39775125
95	Alcoholism_Homo sapiens_hsa05034	0.39726475
96	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.39236461
97	Prion diseases_Homo sapiens_hsa05020	0.37130392
98	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.37109193
99	Estrogen signaling pathway_Homo sapiens_hsa04915	0.36992757
100	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.36543013

CICP16

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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