ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	9.55560856
2	lipopolysaccharide biosynthetic process (GO:0009103)	9.09450412
3	protein-chromophore linkage (GO:0018298)	9.04360987
4	DNA methylation involved in gamete generation (GO:0043046)	8.83773186
5	regulation of meiosis I (GO:0060631)	8.20280742
6	lipopolysaccharide metabolic process (GO:0008653)	8.07639332
7	negative regulation of glycoprotein biosynthetic process (GO:0010561)	7.91538398
8	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	7.76294164
9	regulation of protein glycosylation (GO:0060049)	7.55504062
10	sulfate transmembrane transport (GO:1902358)	7.41093942
11	regulation of pigment cell differentiation (GO:0050932)	7.34306835
12	positive regulation of developmental pigmentation (GO:0048087)	7.25168664
13	paraxial mesoderm development (GO:0048339)	7.22816862
14	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	7.01080203
15	negative regulation of cell cycle G2/M phase transition (GO:1902750)	6.87042160
16	sulfate transport (GO:0008272)	6.30216397
17	piRNA metabolic process (GO:0034587)	6.13789249
18	L-phenylalanine catabolic process (GO:0006559)	5.96674006
19	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	5.96674006
20	negative regulation of glycoprotein metabolic process (GO:1903019)	5.90909034
21	SMAD protein complex assembly (GO:0007183)	5.74943927
22	notochord development (GO:0030903)	5.71199690
23	heme transport (GO:0015886)	5.47600587
24	tyrosine metabolic process (GO:0006570)	5.32596320
25	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	5.15180470
26	L-phenylalanine metabolic process (GO:0006558)	5.15180470
27	ribonucleoprotein complex disassembly (GO:0032988)	5.03015212
28	gamma-aminobutyric acid signaling pathway (GO:0007214)	4.79293103
29	meiotic chromosome segregation (GO:0045132)	4.66798130
30	nodal signaling pathway (GO:0038092)	4.65179595
31	positive regulation of meiosis (GO:0045836)	4.61113014
32	centriole replication (GO:0007099)	4.47757499
33	germinal center formation (GO:0002467)	4.45548904
34	regulation of transforming growth factor beta2 production (GO:0032909)	4.44811639
35	negative regulation of stem cell proliferation (GO:2000647)	4.44187193
36	serotonin receptor signaling pathway (GO:0007210)	4.33386265
37	regulation of interleukin-5 production (GO:0032674)	4.30119961
38	positive regulation of meiotic cell cycle (GO:0051446)	4.27144074
39	regulation of odontogenesis (GO:0042481)	4.24144710
40	response to mercury ion (GO:0046689)	4.23715599
41	protein retention in ER lumen (GO:0006621)	4.16209342
42	glycerol metabolic process (GO:0006071)	4.11053240
43	cellular response to gamma radiation (GO:0071480)	4.07750015
44	DNA damage induced protein phosphorylation (GO:0006975)	4.03181206
45	regulation of rhodopsin mediated signaling pathway (GO:0022400)	4.00961964
46	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.98432018
47	response to epinephrine (GO:0071871)	3.95521017
48	organelle disassembly (GO:1903008)	3.93497726
49	vitamin transmembrane transport (GO:0035461)	3.93287019
50	iron coordination entity transport (GO:1901678)	3.93250029
51	pantothenate metabolic process (GO:0015939)	3.90948084
52	tachykinin receptor signaling pathway (GO:0007217)	3.88493897
53	positive regulation of SMAD protein import into nucleus (GO:0060391)	3.86637349
54	embryonic process involved in female pregnancy (GO:0060136)	3.81944367
55	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.80359594
56	flavonoid metabolic process (GO:0009812)	3.80300466
57	heart valve formation (GO:0003188)	3.73926358
58	rhodopsin mediated signaling pathway (GO:0016056)	3.65004223
59	sulfur compound transport (GO:0072348)	3.62015691
60	alditol metabolic process (GO:0019400)	3.61297043
61	regulation of developmental pigmentation (GO:0048070)	3.59809085
62	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	3.58681570
63	regulation of nephron tubule epithelial cell differentiation (GO:0072182)	3.58359270
64	aromatic amino acid family catabolic process (GO:0009074)	3.56967165
65	negative regulation of neural precursor cell proliferation (GO:2000178)	3.53360599
66	negative regulation of cell-matrix adhesion (GO:0001953)	3.52473878
67	inflammatory response to antigenic stimulus (GO:0002437)	3.51427446
68	toxin metabolic process (GO:0009404)	3.49137923
69	sympathetic nervous system development (GO:0048485)	3.39886257
70	aspartate family amino acid catabolic process (GO:0009068)	3.34939284
71	lysine catabolic process (GO:0006554)	3.21920373
72	lysine metabolic process (GO:0006553)	3.21920373
73	regulation of keratinocyte proliferation (GO:0010837)	3.21317462
74	organ induction (GO:0001759)	3.14796318
75	uterus development (GO:0060065)	3.12895274
76	regulation of epithelial cell differentiation involved in kidney development (GO:2000696)	3.11973080
77	regulation of hair follicle development (GO:0051797)	3.11530412
78	polyol biosynthetic process (GO:0046173)	3.08267951
79	aromatic amino acid family metabolic process (GO:0009072)	3.05818257
80	urate metabolic process (GO:0046415)	3.05793742
81	somite rostral/caudal axis specification (GO:0032525)	3.04696866
82	centriole assembly (GO:0098534)	3.02191888
83	biotin metabolic process (GO:0006768)	2.98169794
84	protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205)	2.97987898
85	regulation of translational termination (GO:0006449)	2.96495333
86	DNA methylation (GO:0006306)	2.96199160
87	DNA alkylation (GO:0006305)	2.96199160
88	regulation of SMAD protein import into nucleus (GO:0060390)	2.94918587
89	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.90579289
90	positive regulation of fatty acid oxidation (GO:0046321)	2.88437322
91	cofactor transport (GO:0051181)	2.87716169
92	membrane lipid biosynthetic process (GO:0046467)	2.87123977
93	negative regulation of BMP signaling pathway (GO:0030514)	2.84347082
94	sphingolipid biosynthetic process (GO:0030148)	2.83384114
95	positive regulation of catecholamine secretion (GO:0033605)	2.72420523
96	regulation of metanephros development (GO:0072215)	2.71858332
97	oogenesis (GO:0048477)	2.70832889
98	sphingosine metabolic process (GO:0006670)	17.7221012
99	diol metabolic process (GO:0034311)	16.0236778
100	sphingoid metabolic process (GO:0046519)	14.2767656

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	AR_21572438_ChIP-Seq_LNCaP_Human	5.51147482
2	IGF1R_20145208_ChIP-Seq_DFB_Human	5.34670726
3	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	3.66961271
4	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	3.65388020
5	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.49256989
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.10512524
7	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	3.01158970
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.58702178
9	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.27213214
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.15593365
11	EGR1_19032775_ChIP-ChIP_M12_Human	2.11310430
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.10299174
13	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	2.07414484
14	P300_19829295_ChIP-Seq_ESCs_Human	2.03843516
15	EZH2_22144423_ChIP-Seq_EOC_Human	1.85310831
16	ER_23166858_ChIP-Seq_MCF-7_Human	1.82676425
17	NANOG_19829295_ChIP-Seq_ESCs_Human	1.82282863
18	SOX2_19829295_ChIP-Seq_ESCs_Human	1.82282863
19	HOXB7_26014856_ChIP-Seq_BT474_Human	1.79709514
20	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.78124423
21	ZNF274_21170338_ChIP-Seq_K562_Hela	1.78021110
22	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	1.77768687
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.68186828
24	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.67605540
25	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.67605540
26	STAT1_20625510_ChIP-Seq_HELA_Human	1.67576736
27	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.65962513
28	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.60798297
29	STAT3_18555785_ChIP-Seq_MESCs_Mouse	1.50062073
30	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.49777982
31	OCT4_20526341_ChIP-Seq_ESCs_Human	1.49646023
32	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.47833329
33	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.46903122
34	TCF4_23295773_ChIP-Seq_U87_Human	1.45774691
35	STAT3_23295773_ChIP-Seq_U87_Human	1.42805847
36	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.37949488
37	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.37109936
38	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.36761138
39	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.33665362
40	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.32273726
41	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.30461621
42	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.29978653
43	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.29780580
44	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.29316559
45	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.27826973
46	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.27159542
47	AR_25329375_ChIP-Seq_VCAP_Human	1.26572256
48	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.26161629
49	AR_19668381_ChIP-Seq_PC3_Human	1.24131575
50	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.22449414
51	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.21948468
52	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.21894662
53	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.21888686
54	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.21705012
55	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.21513922
56	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.20735560
57	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.20449354
58	VDR_22108803_ChIP-Seq_LS180_Human	1.18824546
59	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.18785894
60	NCOR_22424771_ChIP-Seq_293T_Human	1.15502853
61	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.14941339
62	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.14213480
63	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.13385966
64	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.12325236
65	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.11639025
66	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.11428724
67	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.09219722
68	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.08299639
69	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.06843653
70	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.06797679
71	STAT1_17558387_ChIP-Seq_HELA_Human	1.06454324
72	CEBPB_22108803_ChIP-Seq_LS180_Human	1.06371589
73	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.05300129
74	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.05260280
75	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.02253250
76	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.01420877
77	SMAD4_21799915_ChIP-Seq_A2780_Human	1.01419536
78	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.01082372
79	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.00966259
80	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.00857622
81	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.00857622
82	P53_21459846_ChIP-Seq_SAOS-2_Human	0.99528441
83	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.99481650
84	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.98588238
85	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.97914236
86	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.97361289
87	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.97076817
88	MYC_19829295_ChIP-Seq_ESCs_Human	0.96986308
89	NANOG_20526341_ChIP-Seq_ESCs_Human	0.96154068
90	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.95643334
91	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	0.94947853
92	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.94693594
93	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.94224156
94	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.93941403
95	SPI1_20517297_ChIP-Seq_HL60_Human	0.93799131
96	TP53_18474530_ChIP-ChIP_U2OS_Human	0.93591743
97	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.92192498
98	TCF4_22108803_ChIP-Seq_LS180_Human	0.92122047
99	TP53_16413492_ChIP-PET_HCT116_Human	0.91642327
100	CBP_20019798_ChIP-Seq_JUKART_Human	0.91598938

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	9.31227984
2	MP0003136_yellow_coat_color	8.09088369
3	MP0005171_absent_coat_pigmentation	7.68869011
4	MP0002653_abnormal_ependyma_morphology	5.86352373
5	MP0003045_fibrosis	4.62118540
6	MP0003890_abnormal_embryonic-extraembry	4.53885722
7	MP0003646_muscle_fatigue	4.17306690
8	MP0003879_abnormal_hair_cell	3.35847013
9	MP0000569_abnormal_digit_pigmentation	3.27636398
10	MP0004381_abnormal_hair_follicle	3.24134840
11	MP0002138_abnormal_hepatobiliary_system	2.44500417
12	MP0003705_abnormal_hypodermis_morpholog	2.20691242
13	MP0000749_muscle_degeneration	2.18319036
14	MP0005670_abnormal_white_adipose	2.15257177
15	MP0005075_abnormal_melanosome_morpholog	2.13916982
16	MP0005085_abnormal_gallbladder_physiolo	2.10549495
17	MP0002168_other_aberrant_phenotype	1.95216610
18	MP0004147_increased_porphyrin_level	1.83921254
19	MP0002938_white_spotting	1.82001087
20	MP0010352_gastrointestinal_tract_polyps	1.58469952
21	MP0005365_abnormal_bile_salt	1.44065524
22	MP0003195_calcinosis	1.39542563
23	MP0002095_abnormal_skin_pigmentation	1.30409839
24	MP0002075_abnormal_coat/hair_pigmentati	1.30313116
25	MP0004233_abnormal_muscle_weight	1.24323358
26	MP0005174_abnormal_tail_pigmentation	1.22892927
27	MP0003137_abnormal_impulse_conducting	1.08127763
28	MP0005395_other_phenotype	1.08004245
29	MP0002160_abnormal_reproductive_system	1.05652828
30	MP0006054_spinal_hemorrhage	1.01282712
31	MP0005330_cardiomyopathy	0.97817955
32	MP0002269_muscular_atrophy	0.95886811
33	MP0001186_pigmentation_phenotype	0.92846806
34	MP0002735_abnormal_chemical_nociception	0.84476663
35	MP0003300_gastrointestinal_ulcer	0.82827445
36	MP0002254_reproductive_system_inflammat	0.82392235
37	MP0000015_abnormal_ear_pigmentation	0.81337401
38	MP0001501_abnormal_sleep_pattern	0.80916590
39	MP0000427_abnormal_hair_cycle	0.80697803
40	MP0004043_abnormal_pH_regulation	0.74899434
41	MP0002332_abnormal_exercise_endurance	0.70118349
42	MP0003252_abnormal_bile_duct	0.69937870
43	MP0001324_abnormal_eye_pigmentation	0.69199396
44	MP0001984_abnormal_olfaction	0.65456111
45	MP0005319_abnormal_enzyme/_coenzyme	0.64084504
46	MP0003878_abnormal_ear_physiology	0.61579533
47	MP0005377_hearing/vestibular/ear_phenot	0.61579533
48	MP0005076_abnormal_cell_differentiation	0.61494480
49	MP0008770_decreased_survivor_rate	0.61019883
50	MP0002971_abnormal_brown_adipose	0.56017153
51	MP0000534_abnormal_ureter_morphology	0.53820186
52	MP0001486_abnormal_startle_reflex	0.52988630
53	MP0008569_lethality_at_weaning	0.51355053
54	MP0004130_abnormal_muscle_cell	0.49207030
55	MP0001661_extended_life_span	0.48560507
56	MP0002272_abnormal_nervous_system	0.47879519
57	MP0009764_decreased_sensitivity_to	0.47813563
58	MP0002876_abnormal_thyroid_physiology	0.46438870
59	MP0002277_abnormal_respiratory_mucosa	0.45829964
60	MP0002396_abnormal_hematopoietic_system	0.44952091
61	MP0005389_reproductive_system_phenotype	0.42051738
62	MP0003950_abnormal_plasma_membrane	0.41822841
63	MP0001970_abnormal_pain_threshold	0.39788104
64	MP0005410_abnormal_fertilization	0.39550317
65	MP0002928_abnormal_bile_duct	0.39402681
66	MP0009115_abnormal_fat_cell	0.39132395
67	MP0003183_abnormal_peptide_metabolism	0.39114618
68	MP0010307_abnormal_tumor_latency	0.38045529
69	MP0004484_altered_response_of	0.36310790
70	MP0008874_decreased_physiological_sensi	0.36214884
71	MP0005451_abnormal_body_composition	0.35498608
72	MP0009745_abnormal_behavioral_response	0.34803315
73	MP0003937_abnormal_limbs/digits/tail_de	0.34337079
74	MP0003632_abnormal_nervous_system	0.32991556
75	MP0002106_abnormal_muscle_physiology	0.31265148
76	MP0002229_neurodegeneration	0.30159771
77	MP0002751_abnormal_autonomic_nervous	0.30100606
78	MP0001986_abnormal_taste_sensitivity	0.29688180
79	MP0005551_abnormal_eye_electrophysiolog	0.29645230
80	MP0000377_abnormal_hair_follicle	0.29539745
81	MP0003959_abnormal_lean_body	0.29379418
82	MP0003763_abnormal_thymus_physiology	0.29144162
83	MP0005266_abnormal_metabolism	0.29008314
84	MP0001800_abnormal_humoral_immune	0.28539328
85	MP0002064_seizures	0.27420807
86	MP0004142_abnormal_muscle_tone	0.26788767
87	MP0005387_immune_system_phenotype	0.25590528
88	MP0001790_abnormal_immune_system	0.25590528
89	MP0000470_abnormal_stomach_morphology	0.25459580
90	MP0008872_abnormal_physiological_respon	0.25256512
91	MP0009046_muscle_twitch	0.25074746
92	MP0002733_abnormal_thermal_nociception	0.24596559
93	MP0002572_abnormal_emotion/affect_behav	0.22396749
94	MP0000026_abnormal_inner_ear	0.22216557
95	MP0005448_abnormal_energy_balance	0.22162888
96	MP0008875_abnormal_xenobiotic_pharmacok	0.20521840
97	MP0000367_abnormal_coat/_hair	0.19772337
98	MP0005535_abnormal_body_temperature	0.18353782
99	MP0005620_abnormal_muscle_contractility	0.18207674
100	MP0005646_abnormal_pituitary_gland	0.18153008

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Focal motor seizures (HP:0011153)	9.79376433
2	Acanthocytosis (HP:0001927)	7.90500458
3	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	7.87291663
4	Parakeratosis (HP:0001036)	7.38214982
5	Aplastic anemia (HP:0001915)	6.37826141
6	Proximal amyotrophy (HP:0007126)	4.99055950
7	Dialeptic seizures (HP:0011146)	4.95535736
8	Rectal prolapse (HP:0002035)	4.76267781
9	Spontaneous hematomas (HP:0007420)	4.51588859
10	Colon cancer (HP:0003003)	4.50012585
11	Vertebral arch anomaly (HP:0008438)	4.49634721
12	Hematochezia (HP:0002573)	4.46439133
13	Abnormality of aromatic amino acid family metabolism (HP:0004338)	4.46132331
14	Congenital ichthyosiform erythroderma (HP:0007431)	4.43842766
15	Aplasia/Hypoplasia of the uvula (HP:0010293)	4.08218272
16	Scapular winging (HP:0003691)	4.02067531
17	Focal seizures (HP:0007359)	3.95123585
18	Difficulty walking (HP:0002355)	3.92418989
19	Erythroderma (HP:0001019)	3.74032693
20	Ulnar bowing (HP:0003031)	3.72379559
21	Pancreatic cysts (HP:0001737)	3.56470260
22	Poikilocytosis (HP:0004447)	3.56404738
23	Conjunctival telangiectasia (HP:0000524)	3.38196653
24	Esophageal varix (HP:0002040)	3.38151072
25	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.28496750
26	Potter facies (HP:0002009)	3.26671830
27	Facial shape deformation (HP:0011334)	3.26671830
28	Ulnar claw (HP:0001178)	3.24756050
29	Bilateral sensorineural hearing impairment (HP:0008619)	3.20903087
30	Overlapping toe (HP:0001845)	3.16858848
31	Radial bowing (HP:0002986)	3.14876359
32	Broad ribs (HP:0000885)	2.89399265
33	Enlarged kidneys (HP:0000105)	2.85077017
34	Pendular nystagmus (HP:0012043)	2.74787074
35	IgM deficiency (HP:0002850)	2.72107616
36	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.70239850
37	Petechiae (HP:0000967)	2.69471031
38	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.67451422
39	Synostosis of carpal bones (HP:0005048)	2.61762453
40	Abnormality of the vocal cords (HP:0008777)	2.60374866
41	Hypoplastic iliac wings (HP:0002866)	2.56525323
42	Gangrene (HP:0100758)	2.53207038
43	Abnormality of the renal cortex (HP:0011035)	2.51315284
44	Portal hypertension (HP:0001409)	2.48657112
45	Progressive inability to walk (HP:0002505)	2.47121417
46	Abnormality of the shoulder girdle musculature (HP:0001435)	2.44584726
47	Peripheral hypomyelination (HP:0007182)	2.43295592
48	Autoimmune hemolytic anemia (HP:0001890)	2.42475889
49	Abnormality of the hepatic vasculature (HP:0006707)	2.36269387
50	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.34563702
51	Severe visual impairment (HP:0001141)	2.26060868
52	Hypokalemia (HP:0002900)	2.25454867
53	Decreased circulating renin level (HP:0003351)	2.23508474
54	Tarsal synostosis (HP:0008368)	2.20313812
55	Type I transferrin isoform profile (HP:0003642)	2.19583951
56	Hypoalbuminemia (HP:0003073)	2.17058321
57	Abnormal albumin level (HP:0012116)	2.17058321
58	Abnormality of the renal medulla (HP:0100957)	2.15973986
59	Colitis (HP:0002583)	2.15158919
60	Thickened calvaria (HP:0002684)	2.14177787
61	Bowed forearm bones (HP:0003956)	2.13897750
62	Bowing of the arm (HP:0006488)	2.13897750
63	Lack of skin elasticity (HP:0100679)	2.12915294
64	Chronic diarrhea (HP:0002028)	2.11571772
65	Dehydration (HP:0001944)	2.09977775
66	Albinism (HP:0001022)	2.08233616
67	Cerebellar dysplasia (HP:0007033)	2.06670502
68	Abnormality of potassium homeostasis (HP:0011042)	2.03103600
69	Synostosis involving bones of the lower limbs (HP:0009138)	2.01730271
70	Synostosis involving bones of the feet (HP:0009140)	2.01730271
71	Amelogenesis imperfecta (HP:0000705)	10.3447351
72	Recurrent sinusitis (HP:0011108)	1.99041905
73	Abnormality of macular pigmentation (HP:0008002)	1.98277743
74	Tubulointerstitial fibrosis (HP:0005576)	1.95851220
75	Opisthotonus (HP:0002179)	1.95373254
76	Visceral angiomatosis (HP:0100761)	1.94063373
77	Gastrointestinal stroma tumor (HP:0100723)	1.93059675
78	Chromsome breakage (HP:0040012)	1.89890554
79	Neoplasm of the small intestine (HP:0100833)	1.89512322
80	Hemangiomatosis (HP:0007461)	1.84115977
81	Retinitis pigmentosa (HP:0000510)	1.82242902
82	Palmoplantar keratoderma (HP:0000982)	1.80600167
83	Cystic liver disease (HP:0006706)	1.79917263
84	Tubular atrophy (HP:0000092)	1.79295940
85	Purpura (HP:0000979)	1.77830213
86	Aortic valve stenosis (HP:0001650)	1.77330689
87	Carpal synostosis (HP:0009702)	1.75261184
88	Stomach cancer (HP:0012126)	1.75194631
89	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.74993796
90	Carpal bone hypoplasia (HP:0001498)	1.73134214
91	Abnormality of the fingertips (HP:0001211)	1.71576871
92	Nephronophthisis (HP:0000090)	1.70938258
93	Pancytopenia (HP:0001876)	1.70897371
94	Inability to walk (HP:0002540)	1.70345969
95	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.68011355
96	IgA deficiency (HP:0002720)	1.67721428
97	Neoplasm of the colon (HP:0100273)	1.67444570
98	Abnormality of the wing of the ilium (HP:0011867)	1.67020416
99	Ulnar deviation of finger (HP:0009465)	1.64306005
100	Microcytic anemia (HP:0001935)	1.63287513

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK38L	7.35999654
2	LATS2	6.84926799
3	PRKD3	2.99463150
4	STK38	2.82848712
5	ZAK	2.73441344
6	ACVR1B	2.50816657
7	NLK	2.47084164
8	MAP2K2	2.15806179
9	STK3	2.15289772
10	FRK	2.11526069
11	LATS1	11.1269001
12	MELK	1.93979245
13	BMPR1B	1.52999167
14	MAP3K2	1.17361862
15	KSR2	1.13514141
16	NEK2	1.04853541
17	PIK3CG	1.04081125
18	PDPK1	1.02120082
19	PRKAA2	1.01455229
20	IRAK3	0.97885162
21	TAF1	0.86474289
22	GRK7	0.83457500
23	EIF2AK3	0.76742817
24	TGFBR1	0.75533026
25	PINK1	0.72296864
26	CSNK1A1L	0.69424732
27	PRKD1	0.62108628
28	TGFBR2	0.60267212
29	DAPK2	0.55182636
30	MOS	0.54992934
31	ADRBK1	0.54200162
32	NEK9	0.51307049
33	TTK	0.46771209
34	ADRBK2	0.45719606
35	GRK5	0.44610804
36	NME1	0.43968096
37	TNK2	0.42006065
38	MAP2K1	0.37983170
39	STK11	0.36506884
40	PIM1	0.33905589
41	STK10	0.30378876
42	TAOK3	0.23056540
43	WNK4	0.21515296
44	PLK1	0.19191548
45	CHEK2	0.17617900
46	CSNK1D	0.17296089
47	PRKCI	0.16482403
48	MAP3K1	0.12997555
49	MAPK3	0.11117903
50	TXK	0.10690009
51	AKT2	0.09596666
52	IRAK4	0.09198648
53	OXSR1	0.09180986
54	ABL1	0.09058968
55	JAK2	0.08943910
56	MAP3K7	0.08082954
57	INSRR	0.07148115
58	ITK	0.06646978
59	FER	0.05887515
60	CDK3	0.05517500
61	TEC	0.03589855
62	RET	0.03308797
63	MAPK1	0.03148828
64	PRKACA	0.02439578
65	EIF2AK2	0.02201532
66	PTK2B	0.01745858
67	BLK	0.00152329
68	MKNK2	-0.0904753
69	PRKCB	-0.0861948
70	PRKCG	-0.0828149
71	PAK1	-0.0814490
72	PLK2	-0.0784086
73	MATK	-0.0763846
74	MAP4K2	-0.0758958
75	GSK3B	-0.0698694
76	CDK19	-0.0697206
77	BTK	-0.0696589
78	CDK4	-0.0645340
79	CSNK1A1	-0.0606336
80	PRKCH	-0.0578609
81	ATR	-0.0570999
82	PRKG2	-0.0560650
83	PLK3	-0.0552704
84	AKT1	-0.0498991
85	CDK5	-0.0431362
86	MUSK	-0.0399041
87	MAPK15	-0.0287362
88	STK24	-0.0285669
89	NEK1	-0.0281774
90	PDK1	-0.0262903
91	STK39	-0.0261733
92	OBSCN	-0.0244027
93	PRKCE	-0.0214780
94	CAMK2B	-0.0193876
95	PRKACB	-0.0170888
96	MAP3K8	-0.0150672
97	CAMK2A	-0.0127068
98	NEK6	-0.0120796
99	MAPK8	-0.0104503
100	MAPK7	-0.0080124

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	9.11251216
2	Phototransduction_Homo sapiens_hsa04744	4.43159524
3	Sphingolipid metabolism_Homo sapiens_hsa00600	4.07667390
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	4.02426132
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.24207565
6	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.86490879
7	Nicotine addiction_Homo sapiens_hsa05033	2.77742563
8	Phenylalanine metabolism_Homo sapiens_hsa00360	2.19987201
9	Taste transduction_Homo sapiens_hsa04742	2.11330120
10	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.05401312
11	N-Glycan biosynthesis_Homo sapiens_hsa00510	2.04966794
12	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.92678957
13	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.81297313
14	Morphine addiction_Homo sapiens_hsa05032	1.70648263
15	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.58984962
16	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.52138252
17	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.29121536
18	Histidine metabolism_Homo sapiens_hsa00340	1.28850305
19	GABAergic synapse_Homo sapiens_hsa04727	1.27217609
20	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.26985636
21	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.13983891
22	Calcium signaling pathway_Homo sapiens_hsa04020	1.13287251
23	Viral myocarditis_Homo sapiens_hsa05416	1.12559815
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.11069733
25	Sphingolipid signaling pathway_Homo sapiens_hsa04071	1.06473874
26	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.03931207
27	VEGF signaling pathway_Homo sapiens_hsa04370	1.02137993
28	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.98580162
29	One carbon pool by folate_Homo sapiens_hsa00670	0.98331237
30	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.91929169
31	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.88802710
32	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.87407690
33	Tyrosine metabolism_Homo sapiens_hsa00350	0.85978722
34	ABC transporters_Homo sapiens_hsa02010	0.79449834
35	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.76653987
36	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.72854786
37	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.71942403
38	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.69544462
39	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.68988258
40	Glutamatergic synapse_Homo sapiens_hsa04724	0.66186659
41	Glycerolipid metabolism_Homo sapiens_hsa00561	0.66126349
42	Nitrogen metabolism_Homo sapiens_hsa00910	0.64600272
43	Bile secretion_Homo sapiens_hsa04976	0.62843650
44	Serotonergic synapse_Homo sapiens_hsa04726	0.61202544
45	Adherens junction_Homo sapiens_hsa04520	0.59613789
46	Basal transcription factors_Homo sapiens_hsa03022	0.59328011
47	Colorectal cancer_Homo sapiens_hsa05210	0.58328979
48	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.57848000
49	Butanoate metabolism_Homo sapiens_hsa00650	0.56763127
50	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.55624182
51	cAMP signaling pathway_Homo sapiens_hsa04024	0.52817323
52	ECM-receptor interaction_Homo sapiens_hsa04512	0.52652740
53	Thyroid cancer_Homo sapiens_hsa05216	0.51720847
54	beta-Alanine metabolism_Homo sapiens_hsa00410	0.47584518
55	Hippo signaling pathway_Homo sapiens_hsa04390	0.46843649
56	Fatty acid degradation_Homo sapiens_hsa00071	0.46823161
57	Tuberculosis_Homo sapiens_hsa05152	0.45190176
58	Pyruvate metabolism_Homo sapiens_hsa00620	0.45128231
59	Lysine degradation_Homo sapiens_hsa00310	0.44314482
60	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.42711168
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.41641568
62	Pancreatic cancer_Homo sapiens_hsa05212	0.39865407
63	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.39665895
64	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.37919732
65	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.36348072
66	Collecting duct acid secretion_Homo sapiens_hsa04966	0.35636837
67	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.35272338
68	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.34514001
69	Olfactory transduction_Homo sapiens_hsa04740	0.28173296
70	Homologous recombination_Homo sapiens_hsa03440	0.26502183
71	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.25681000
72	Basal cell carcinoma_Homo sapiens_hsa05217	0.25602297
73	African trypanosomiasis_Homo sapiens_hsa05143	0.24282210
74	Cell cycle_Homo sapiens_hsa04110	0.22925869
75	Salivary secretion_Homo sapiens_hsa04970	0.22707159
76	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.22083771
77	Sulfur relay system_Homo sapiens_hsa04122	0.21859485
78	Melanogenesis_Homo sapiens_hsa04916	0.20592945
79	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.20474980
80	Fanconi anemia pathway_Homo sapiens_hsa03460	0.20256670
81	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.19183834
82	Arginine and proline metabolism_Homo sapiens_hsa00330	0.19057412
83	Oocyte meiosis_Homo sapiens_hsa04114	0.17963318
84	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.17315569
85	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.16854634
86	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.15883933
87	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.14736585
88	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.13924536
89	Estrogen signaling pathway_Homo sapiens_hsa04915	0.13589821
90	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.13256016
91	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.13146851
92	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.11899156
93	Folate biosynthesis_Homo sapiens_hsa00790	0.11009165
94	Metabolic pathways_Homo sapiens_hsa01100	0.10622272
95	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.10556860
96	Circadian entrainment_Homo sapiens_hsa04713	0.10380164
97	Type II diabetes mellitus_Homo sapiens_hsa04930	0.10299817
98	Gastric acid secretion_Homo sapiens_hsa04971	0.10180506
99	Retinol metabolism_Homo sapiens_hsa00830	0.10170065
100	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.09514845

CICP19

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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