CICP22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuronal action potential propagation (GO:0019227)8.85532313
2gamma-aminobutyric acid transport (GO:0015812)8.63782411
3positive regulation of action potential (GO:0045760)8.01792656
4detection of light stimulus involved in sensory perception (GO:0050962)7.00709031
5detection of light stimulus involved in visual perception (GO:0050908)7.00709031
6negative regulation of retinoic acid receptor signaling pathway (GO:0048387)6.32199575
7fusion of sperm to egg plasma membrane (GO:0007342)6.01689361
8neuronal action potential (GO:0019228)5.98930985
9histone H4-K12 acetylation (GO:0043983)5.73836352
10nucleoside transmembrane transport (GO:1901642)5.64082844
11serotonin metabolic process (GO:0042428)5.57743641
12primary amino compound metabolic process (GO:1901160)5.49464681
13mucosal-associated lymphoid tissue development (GO:0048537)5.36163127
14Peyers patch development (GO:0048541)5.36163127
15behavioral response to nicotine (GO:0035095)5.05407791
16regulation of retinoic acid receptor signaling pathway (GO:0048385)5.01187987
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.96714960
18regulation of acrosome reaction (GO:0060046)4.77537125
19regulation of chromatin binding (GO:0035561)4.73302627
20regulation of gene silencing by RNA (GO:0060966)4.55682757
21regulation of posttranscriptional gene silencing (GO:0060147)4.55682757
22regulation of gene silencing by miRNA (GO:0060964)4.55682757
23cellular ketone body metabolic process (GO:0046950)4.49936438
24regulation of action potential (GO:0098900)4.44367465
25plasma membrane fusion (GO:0045026)4.27909243
26phosphatidylinositol acyl-chain remodeling (GO:0036149)3.92112441
27nucleoside transport (GO:0015858)3.92056901
28ketone body metabolic process (GO:1902224)3.91942215
29cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.91887595
30positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.91344207
31protein-chromophore linkage (GO:0018298)3.80024902
32positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.79621396
33spinal cord motor neuron differentiation (GO:0021522)3.70455625
34NLS-bearing protein import into nucleus (GO:0006607)3.70206131
35neuromuscular junction development (GO:0007528)3.68690906
36phosphatidylserine acyl-chain remodeling (GO:0036150)3.67390419
37cilium or flagellum-dependent cell motility (GO:0001539)3.67005296
38gamma-aminobutyric acid signaling pathway (GO:0007214)3.60817588
39regulation of voltage-gated calcium channel activity (GO:1901385)3.54753259
40behavioral response to ethanol (GO:0048149)3.53858785
41keratinocyte development (GO:0003334)3.50394420
42indole-containing compound metabolic process (GO:0042430)3.48109666
43positive regulation of CREB transcription factor activity (GO:0032793)3.47768928
44outflow tract septum morphogenesis (GO:0003148)3.41043734
45response to acidic pH (GO:0010447)3.34696927
46positive regulation of mRNA catabolic process (GO:0061014)3.30788569
47striatum development (GO:0021756)3.28666632
48regulation of female gonad development (GO:2000194)3.24880585
49positive regulation of cAMP-mediated signaling (GO:0043950)3.23509344
50seminiferous tubule development (GO:0072520)3.17018746
51multicellular organism reproduction (GO:0032504)3.15647871
52phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.07938981
53maturation of 5.8S rRNA (GO:0000460)3.05874012
54striated muscle atrophy (GO:0014891)3.05630908
55action potential (GO:0001508)3.03166027
56UDP-N-acetylglucosamine metabolic process (GO:0006047)3.02415963
57transepithelial transport (GO:0070633)2.99777397
58opioid receptor signaling pathway (GO:0038003)2.98773137
59histone-serine phosphorylation (GO:0035404)2.96572847
60synaptic transmission, glutamatergic (GO:0035249)2.95988572
61positive regulation of uterine smooth muscle contraction (GO:0070474)2.94215098
62circadian sleep/wake cycle process (GO:0022410)2.92226376
63motile cilium assembly (GO:0044458)2.91142019
64male meiosis (GO:0007140)2.90418760
65establishment of planar polarity (GO:0001736)2.90024677
66establishment of tissue polarity (GO:0007164)2.90024677
67regulation of mRNA catabolic process (GO:0061013)2.89150960
68regulation of histone phosphorylation (GO:0033127)2.89149040
69cornea development in camera-type eye (GO:0061303)2.87943017
70cytoplasmic mRNA processing body assembly (GO:0033962)2.87084641
71epithelial cilium movement (GO:0003351)2.86608802
72regulation of Rab GTPase activity (GO:0032313)2.83204487
73positive regulation of Rab GTPase activity (GO:0032851)2.83204487
74ventricular septum development (GO:0003281)2.82003009
75regulation of sensory perception of pain (GO:0051930)2.81619570
76regulation of sensory perception (GO:0051931)2.81619570
77protein import into peroxisome matrix (GO:0016558)2.81035984
78interkinetic nuclear migration (GO:0022027)2.80911237
79thymus development (GO:0048538)2.76669253
80cardiac septum development (GO:0003279)2.74530590
81negative regulation of T cell differentiation in thymus (GO:0033085)2.73540148
82positive regulation of sodium ion transmembrane transport (GO:1902307)2.71438083
83connective tissue development (GO:0061448)2.70338657
84sensory perception of taste (GO:0050909)2.68759875
85long-term memory (GO:0007616)2.65649587
86negative regulation of TOR signaling (GO:0032007)2.64678039
87positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.64299420
88regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.64299420
89skeletal muscle adaptation (GO:0043501)2.64287764
90tryptophan catabolic process (GO:0006569)2.63614778
91indole-containing compound catabolic process (GO:0042436)2.63614778
92indolalkylamine catabolic process (GO:0046218)2.63614778
93Sertoli cell development (GO:0060009)2.63298228
94detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.62382910
95DNA methylation involved in gamete generation (GO:0043046)2.61521761
96positive regulation of protein kinase C signaling (GO:0090037)2.60283245
97neuron remodeling (GO:0016322)2.60217126
98regulation of inositol phosphate biosynthetic process (GO:0010919)2.60117658
99G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.57502385
100calcium-mediated signaling using intracellular calcium source (GO:0035584)2.56953357

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human8.93796931
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse5.18506541
3ZNF274_21170338_ChIP-Seq_K562_Hela3.49249847
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.32345418
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.00168577
6GBX2_23144817_ChIP-Seq_PC3_Human2.79845441
7VDR_22108803_ChIP-Seq_LS180_Human2.36083969
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.28815180
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20107411
10DROSHA_22980978_ChIP-Seq_HELA_Human2.01904453
11CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78691413
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.63703948
13EZH2_27304074_Chip-Seq_ESCs_Mouse1.63360284
14CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59387533
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57772486
16REST_21632747_ChIP-Seq_MESCs_Mouse1.56517432
17TDRD3_21172665_ChIP-Seq_MCF-7_Human1.51265079
18ER_23166858_ChIP-Seq_MCF-7_Human1.47761798
19EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47482381
20ERA_21632823_ChIP-Seq_H3396_Human1.43719093
21RUNX2_22187159_ChIP-Seq_PCA_Human1.41165533
22JARID2_20075857_ChIP-Seq_MESCs_Mouse1.38921564
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.36924852
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.34762451
25RNF2_27304074_Chip-Seq_NSC_Mouse1.34610972
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.33261830
27BCAT_22108803_ChIP-Seq_LS180_Human1.33079033
28GATA3_21878914_ChIP-Seq_MCF-7_Human1.31218768
29RAC3_21632823_ChIP-Seq_H3396_Human1.30658853
30AR_25329375_ChIP-Seq_VCAP_Human1.26862554
31FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24357199
32FOXA1_25329375_ChIP-Seq_VCAP_Human1.24357199
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22201013
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.21452271
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21058600
36JARID2_20064375_ChIP-Seq_MESCs_Mouse1.20458700
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17654401
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17169444
39ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16578567
40EWS_26573619_Chip-Seq_HEK293_Human1.16538655
41TAF2_19829295_ChIP-Seq_ESCs_Human1.15707044
42P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.15203210
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.12234294
44OCT1_27270436_Chip-Seq_PROSTATE_Human1.11939464
45P53_21459846_ChIP-Seq_SAOS-2_Human1.11707840
46ETV1_20927104_ChIP-Seq_GIST48_Human1.10532003
47CTCF_27219007_Chip-Seq_Bcells_Human1.10149553
48E2F1_20622854_ChIP-Seq_HELA_Human1.09922917
49AR_21572438_ChIP-Seq_LNCaP_Human1.09659897
50STAT3_23295773_ChIP-Seq_U87_Human1.07249163
51EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05347588
52RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05347588
53ARNT_22903824_ChIP-Seq_MCF-7_Human1.04644915
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03441569
55TAF15_26573619_Chip-Seq_HEK293_Human1.02788164
56OCT4_20526341_ChIP-Seq_ESCs_Human1.02637240
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01989454
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00233759
59NANOG_20526341_ChIP-Seq_ESCs_Human0.99875633
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99487312
61NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98367061
62BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98141506
63BCOR_27268052_Chip-Seq_Bcells_Human0.95480636
64SMAD4_21741376_ChIP-Seq_EPCs_Human0.95302857
65KAP1_22055183_ChIP-Seq_ESCs_Mouse0.95200481
66SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.93713127
67EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93239877
68CBX2_22325352_ChIP-Seq_293T-Rex_Human0.92008708
69TCF4_23295773_ChIP-Seq_U87_Human0.91809704
70EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91318372
71AHR_22903824_ChIP-Seq_MCF-7_Human0.91012749
72KDM2B_26808549_Chip-Seq_REH_Human0.90647930
73SMAD3_21741376_ChIP-Seq_ESCs_Human0.90579668
74NCOR_22424771_ChIP-Seq_293T_Human0.90301434
75P300_19829295_ChIP-Seq_ESCs_Human0.88079200
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87877744
77BCL6_27268052_Chip-Seq_Bcells_Human0.87706916
78SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.87469591
79MYC_27129775_Chip-Seq_CORNEA_Mouse0.87332978
80PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86881630
81HOXB7_26014856_ChIP-Seq_BT474_Human0.86450746
82SMAD3_21741376_ChIP-Seq_EPCs_Human0.86371834
83SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.85339992
84MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.84966034
85SMAD4_21741376_ChIP-Seq_ESCs_Human0.84699325
86RBPJ_21746931_ChIP-Seq_IB4_Human0.84356118
87MYC_18940864_ChIP-ChIP_HL60_Human0.83926694
88CTCF_20526341_ChIP-Seq_ESCs_Human0.83664673
89FUS_26573619_Chip-Seq_HEK293_Human0.83662011
90PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83652113
91P68_20966046_ChIP-Seq_HELA_Human0.83395816
92TP53_16413492_ChIP-PET_HCT116_Human0.82827753
93YY1_22570637_ChIP-Seq_MALME-3M_Human0.82602266
94CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.82449328
95RING1B_27294783_Chip-Seq_ESCs_Mouse0.81964957
96REST_18959480_ChIP-ChIP_MESCs_Mouse0.81907932
97SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.81391820
98PHF8_20622854_ChIP-Seq_HELA_Human0.81054611
99PHF8_20622853_ChIP-Seq_HELA_Human0.79890941
100EED_16625203_ChIP-ChIP_MESCs_Mouse0.79533871

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology5.31468532
2MP0003136_yellow_coat_color4.63948581
3MP0005174_abnormal_tail_pigmentation2.91767217
4MP0005423_abnormal_somatic_nervous2.84897328
5MP0003880_abnormal_central_pattern2.73934547
6MP0005171_absent_coat_pigmentation2.71776702
7MP0003195_calcinosis2.63457943
8MP0005248_abnormal_Harderian_gland2.60104744
9MP0003878_abnormal_ear_physiology2.53856455
10MP0005377_hearing/vestibular/ear_phenot2.53856455
11MP0005645_abnormal_hypothalamus_physiol2.36380702
12MP0009745_abnormal_behavioral_response2.25854397
13MP0006292_abnormal_olfactory_placode2.24851142
14MP0002102_abnormal_ear_morphology2.17109185
15MP0005410_abnormal_fertilization2.17040043
16MP0003283_abnormal_digestive_organ2.09307160
17MP0005551_abnormal_eye_electrophysiolog2.03839121
18MP0002282_abnormal_trachea_morphology1.98843719
19MP0008877_abnormal_DNA_methylation1.96807155
20MP0001986_abnormal_taste_sensitivity1.91968381
21MP0002736_abnormal_nociception_after1.91659432
22MP0008875_abnormal_xenobiotic_pharmacok1.81532126
23MP0001968_abnormal_touch/_nociception1.81483300
24MP0002064_seizures1.80901481
25MP0001873_stomach_inflammation1.77617307
26MP0005083_abnormal_biliary_tract1.75862977
27MP0002249_abnormal_larynx_morphology1.75050180
28MP0009046_muscle_twitch1.74936676
29MP0005365_abnormal_bile_salt1.74748737
30MP0003938_abnormal_ear_development1.72013235
31MP0009840_abnormal_foam_cell1.67558461
32MP0000566_synostosis1.64409848
33MP0002272_abnormal_nervous_system1.63499422
34MP0000631_abnormal_neuroendocrine_gland1.61077253
35MP0001486_abnormal_startle_reflex1.58565547
36MP0005451_abnormal_body_composition1.54837030
37MP0000613_abnormal_salivary_gland1.54671075
38MP0004133_heterotaxia1.51877393
39MP0000534_abnormal_ureter_morphology1.51290343
40MP0003119_abnormal_digestive_system1.41712767
41MP0005389_reproductive_system_phenotype1.40329689
42MP0002638_abnormal_pupillary_reflex1.40005197
43MP0003698_abnormal_male_reproductive1.35721630
44MP0004859_abnormal_synaptic_plasticity1.34998083
45MP0002734_abnormal_mechanical_nocicepti1.31400573
46MP0003635_abnormal_synaptic_transmissio1.29798052
47MP0002909_abnormal_adrenal_gland1.28848397
48MP0004885_abnormal_endolymph1.23231131
49MP0001188_hyperpigmentation1.21013486
50MP0001542_abnormal_bone_strength1.20456438
51MP0009379_abnormal_foot_pigmentation1.19544249
52MP0002067_abnormal_sensory_capabilities1.19506305
53MP0001485_abnormal_pinna_reflex1.18147529
54MP0004147_increased_porphyrin_level1.18111959
55MP0002160_abnormal_reproductive_system1.15318017
56MP0000026_abnormal_inner_ear1.10804285
57MP0003866_abnormal_defecation1.09924482
58MP0003718_maternal_effect1.07251767
59MP0008789_abnormal_olfactory_epithelium1.06069898
60MP0005085_abnormal_gallbladder_physiolo1.05992897
61MP0001919_abnormal_reproductive_system1.05608394
62MP0004858_abnormal_nervous_system1.03136568
63MP0001929_abnormal_gametogenesis1.02401942
64MP0003646_muscle_fatigue0.99575041
65MP0002932_abnormal_joint_morphology0.98068738
66MP0000955_abnormal_spinal_cord0.97569472
67MP0001756_abnormal_urination0.96302078
68MP0002572_abnormal_emotion/affect_behav0.95433603
69MP0005647_abnormal_sex_gland0.94582155
70MP0005671_abnormal_response_to0.94244811
71MP0002210_abnormal_sex_determination0.93819262
72MP0001970_abnormal_pain_threshold0.93721212
73MP0002735_abnormal_chemical_nociception0.88833505
74MP0003115_abnormal_respiratory_system0.86974976
75MP0002751_abnormal_autonomic_nervous0.86939272
76MP0000639_abnormal_adrenal_gland0.86632324
77MP0005187_abnormal_penis_morphology0.83906273
78MP0002184_abnormal_innervation0.83394221
79MP0001963_abnormal_hearing_physiology0.82730698
80MP0000778_abnormal_nervous_system0.80699116
81MP0001340_abnormal_eyelid_morphology0.80218422
82MP0002752_abnormal_somatic_nervous0.79461125
83MP0002089_abnormal_postnatal_growth/wei0.77988590
84MP0005386_behavior/neurological_phenoty0.74211191
85MP0004924_abnormal_behavior0.74211191
86MP0005499_abnormal_olfactory_system0.73937105
87MP0005394_taste/olfaction_phenotype0.73937105
88MP0002557_abnormal_social/conspecific_i0.73552451
89MP0001324_abnormal_eye_pigmentation0.73017013
90MP0000163_abnormal_cartilage_morphology0.72528462
91MP0000653_abnormal_sex_gland0.72213641
92MP0002161_abnormal_fertility/fecundity0.72054041
93MP0005503_abnormal_tendon_morphology0.71938451
94MP0003315_abnormal_perineum_morphology0.70954033
95MP0002063_abnormal_learning/memory/cond0.70086735
96MP0000470_abnormal_stomach_morphology0.70036985
97MP0003890_abnormal_embryonic-extraembry0.69218527
98MP0003943_abnormal_hepatobiliary_system0.68821089
99MP0004130_abnormal_muscle_cell0.67810171
100MP0002152_abnormal_brain_morphology0.67211605

Predicted human phenotypes

RankGene SetZ-score
1Bilateral sensorineural hearing impairment (HP:0008619)7.21471347
2Annular pancreas (HP:0001734)5.57466217
3Tubular atrophy (HP:0000092)5.05266115
4Birth length less than 3rd percentile (HP:0003561)4.46462385
5Tinnitus (HP:0000360)4.32690588
6Hyperventilation (HP:0002883)4.03315082
7Abnormal pancreas size (HP:0012094)3.99998281
8Abnormal drinking behavior (HP:0030082)3.88408113
9Polydipsia (HP:0001959)3.88408113
10Gaze-evoked nystagmus (HP:0000640)3.59978599
11Abnormality of dentin (HP:0010299)3.56052852
12Attenuation of retinal blood vessels (HP:0007843)3.53482760
13Genetic anticipation (HP:0003743)3.39500106
14Tubulointerstitial fibrosis (HP:0005576)3.38963703
15Nephronophthisis (HP:0000090)3.21888776
16Concave nail (HP:0001598)3.11483233
17Hemiparesis (HP:0001269)3.11321235
18Abnormality of the renal medulla (HP:0100957)3.01934973
19Curly hair (HP:0002212)3.01847080
20Anophthalmia (HP:0000528)2.97907448
21Inappropriate behavior (HP:0000719)2.96613619
22Absent/shortened dynein arms (HP:0200106)2.95452009
23Dynein arm defect of respiratory motile cilia (HP:0012255)2.95452009
24Bicornuate uterus (HP:0000813)2.93793541
25Clumsiness (HP:0002312)2.88441273
26Facial shape deformation (HP:0011334)2.87296042
27Potter facies (HP:0002009)2.87296042
28Inability to walk (HP:0002540)2.87170964
29Polyuria (HP:0000103)2.83462205
30Febrile seizures (HP:0002373)2.80755221
31Supernumerary spleens (HP:0009799)2.79509419
32Pancreatic cysts (HP:0001737)2.78874783
33Enlarged penis (HP:0000040)2.66298068
34Coronal craniosynostosis (HP:0004440)2.63560018
35Breast hypoplasia (HP:0003187)2.62754276
36Renovascular hypertension (HP:0100817)2.62118559
37Dyskinesia (HP:0100660)2.60928095
38Abnormality of the renal cortex (HP:0011035)2.57013973
39Abnormality of the dental pulp (HP:0006479)2.54879921
40Abnormal urine output (HP:0012590)2.53199947
41Enlarged epiphyses (HP:0010580)2.52628218
42Small hand (HP:0200055)2.51991544
43Protruding tongue (HP:0010808)2.46942423
44Decreased central vision (HP:0007663)2.46887362
45Patellar aplasia (HP:0006443)2.46560932
46Flat occiput (HP:0005469)2.42600562
47Chorioretinal atrophy (HP:0000533)2.42397265
48Hypophosphatemic rickets (HP:0004912)2.39421784
49Large for gestational age (HP:0001520)2.35298073
50Tubulointerstitial abnormality (HP:0001969)2.28368056
51Aplasia/Hypoplasia of the patella (HP:0006498)2.28010278
52Abnormality of renal excretion (HP:0011036)2.26091921
53Renal duplication (HP:0000075)2.24329645
54Bony spicule pigmentary retinopathy (HP:0007737)2.23504048
55Nasolacrimal duct obstruction (HP:0000579)2.23285882
56Hyperglycinuria (HP:0003108)2.22004527
57Abnormality of midbrain morphology (HP:0002418)2.20537839
58Molar tooth sign on MRI (HP:0002419)2.20537839
59Elfin facies (HP:0004428)2.19837095
60Pendular nystagmus (HP:0012043)2.18062200
61Generalized myoclonic seizures (HP:0002123)2.17085423
62Disinhibition (HP:0000734)2.16590287
63Congenital stationary night blindness (HP:0007642)2.16050139
64Overriding aorta (HP:0002623)2.15034514
65Relative macrocephaly (HP:0004482)2.13561974
66Progressive inability to walk (HP:0002505)2.08036545
67Congenital sensorineural hearing impairment (HP:0008527)2.05747990
68Microretrognathia (HP:0000308)2.05040791
69Partial agenesis of the corpus callosum (HP:0001338)2.03891193
70Mesangial abnormality (HP:0001966)2.01819839
71Progressive cerebellar ataxia (HP:0002073)2.01229480
72Acanthocytosis (HP:0001927)2.00283641
73Aplasia/Hypoplasia of the tibia (HP:0005772)1.98356201
74Humeroradial synostosis (HP:0003041)1.96685909
75Synostosis involving the elbow (HP:0003938)1.96685909
76Focal seizures (HP:0007359)1.93607952
77Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93577580
78Abnormality of alanine metabolism (HP:0010916)1.93577580
79Hyperalaninemia (HP:0003348)1.93577580
80Severe muscular hypotonia (HP:0006829)1.93572237
81Bulbous nose (HP:0000414)1.91709598
82Azoospermia (HP:0000027)1.91553546
83Abnormality of the diencephalon (HP:0010662)1.90329305
84Turricephaly (HP:0000262)1.87736270
85Status epilepticus (HP:0002133)1.84101708
86Broad nasal tip (HP:0000455)1.83084496
87Ulnar claw (HP:0001178)1.81178509
88Hyperglycinemia (HP:0002154)1.78720661
89Abnormality of the lacrimal duct (HP:0011481)1.78049496
90Focal motor seizures (HP:0011153)1.75908894
91Abnormal lung lobation (HP:0002101)1.71539865
92Pancreatic fibrosis (HP:0100732)1.70979164
93Osteomalacia (HP:0002749)1.70609207
94Atonic seizures (HP:0010819)1.69129291
95Hemiplegia (HP:0002301)1.69056451
96Abnormal respiratory motile cilium morphology (HP:0005938)1.68858545
97Abnormal respiratory epithelium morphology (HP:0012253)1.68858545
98Posterior embryotoxon (HP:0000627)1.66830228
99Macular degeneration (HP:0000608)1.66536564
100Drooling (HP:0002307)1.66130010

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK25.86360464
2ACVR1B5.31251381
3MKNK24.04984906
4STK393.71198290
5MAP3K93.47676992
6BMPR1B2.89228657
7WNK42.78885105
8NTRK22.51644732
9OXSR12.47207119
10TYRO32.32740625
11PLK42.31906474
12MAP3K62.13600341
13MAPK152.05642393
14PTK2B1.96897275
15MAP2K71.95526350
16NEK21.92743912
17MAP3K41.84448616
18TLK11.73472764
19TNIK1.72140106
20MKNK11.70308930
21NTRK31.58449359
22CAMKK21.57189060
23INSRR1.46432086
24BRSK21.45171051
25DDR21.33779344
26ADRBK21.32752420
27MAP2K11.26230036
28PIK3CA1.25054560
29BCR1.23394740
30MAP2K41.20765474
31RAF11.14342564
32DAPK21.12443906
33NEK91.12211721
34PASK1.11529187
35CAMKK11.10000037
36STK381.09486109
37TGFBR11.09086244
38KSR21.06130261
39GRK11.03776425
40CDK120.98615317
41ADRBK10.93497935
42PIK3CG0.93345469
43PINK10.88258173
44WNK10.88056319
45CSNK1D0.87760029
46PRKCG0.81706124
47PRKCQ0.78914884
48CAMK1D0.77775982
49PNCK0.76402020
50MET0.70977300
51BMX0.67826916
52MAP3K130.64923473
53MARK30.63341505
54CDK70.62278610
55MARK20.60197997
56NTRK10.59146262
57RET0.58066065
58SIK10.57280617
59RPS6KA60.54848614
60MST1R0.53381400
61MUSK0.52771143
62MARK10.47596808
63CASK0.42840136
64IRAK10.42561797
65ARAF0.42298154
66DYRK1B0.41862623
67CAMK1G0.40759197
68MATK0.34443399
69TRIB30.34027216
70SIK30.31627071
71AKT30.31189379
72PLK10.30628465
73NUAK10.30384959
74ERBB20.30267213
75PTK60.30105458
76IRAK40.27225431
77BRSK10.27176960
78EPHA20.27151543
79PKN10.26182317
80EEF2K0.23997350
81IKBKB0.23829954
82LYN0.23577091
83FRK0.22995919
84FGFR20.22958528
85FLT30.22708952
86MAPK110.22389573
87CDK10.21966447
88DYRK1A0.20120773
89SGK2230.19425715
90SGK4940.19425715
91PLK20.17602588
92LATS20.17327445
93MAPK80.16857087
94BLK0.16664672
95CAMK2A0.15716741
96PHKG10.15205098
97PHKG20.15205098
98TAOK10.15106403
99MAPK130.14820878
100GSK3B0.14481279

Predicted pathways (KEGG)

RankGene SetZ-score
1Selenocompound metabolism_Homo sapiens_hsa004504.09907380
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.57300880
3Linoleic acid metabolism_Homo sapiens_hsa005913.16527600
4Fatty acid biosynthesis_Homo sapiens_hsa000612.97215745
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.88841289
6Nicotine addiction_Homo sapiens_hsa050332.55862046
7Sulfur relay system_Homo sapiens_hsa041222.45773933
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.42379800
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.41815139
10Nitrogen metabolism_Homo sapiens_hsa009102.37005926
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.35362750
12Taste transduction_Homo sapiens_hsa047422.25821192
13Ether lipid metabolism_Homo sapiens_hsa005652.11524967
14Ovarian steroidogenesis_Homo sapiens_hsa049132.02574958
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80763587
16ABC transporters_Homo sapiens_hsa020101.73248681
17Olfactory transduction_Homo sapiens_hsa047401.64566558
18Phototransduction_Homo sapiens_hsa047441.63347428
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.46902860
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.46814429
21Calcium signaling pathway_Homo sapiens_hsa040201.41045873
22Histidine metabolism_Homo sapiens_hsa003401.40790148
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.39073867
24Gastric acid secretion_Homo sapiens_hsa049711.37569860
25Tryptophan metabolism_Homo sapiens_hsa003801.32262542
26Butanoate metabolism_Homo sapiens_hsa006501.31543851
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.24106980
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23639537
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.16086251
30Glutamatergic synapse_Homo sapiens_hsa047241.13736079
31Glycerolipid metabolism_Homo sapiens_hsa005611.09154374
32Arachidonic acid metabolism_Homo sapiens_hsa005901.08638839
33Cocaine addiction_Homo sapiens_hsa050301.06686544
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.04222638
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03162989
36Fat digestion and absorption_Homo sapiens_hsa049751.02504735
37Morphine addiction_Homo sapiens_hsa050321.02412230
38Glycerophospholipid metabolism_Homo sapiens_hsa005640.97821417
39Long-term depression_Homo sapiens_hsa047300.96835702
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92454138
41Thyroid hormone synthesis_Homo sapiens_hsa049180.90937228
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90821797
43Lysine degradation_Homo sapiens_hsa003100.86441991
44MAPK signaling pathway_Homo sapiens_hsa040100.86308387
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85650037
46Insulin secretion_Homo sapiens_hsa049110.84866078
47Bile secretion_Homo sapiens_hsa049760.82764872
48Circadian entrainment_Homo sapiens_hsa047130.77664907
49Intestinal immune network for IgA production_Homo sapiens_hsa046720.77495742
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.77018140
51beta-Alanine metabolism_Homo sapiens_hsa004100.73995067
52Oxytocin signaling pathway_Homo sapiens_hsa049210.72527713
53Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70646769
54Basal cell carcinoma_Homo sapiens_hsa052170.70569108
55Serotonergic synapse_Homo sapiens_hsa047260.70456527
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.70375991
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67285269
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66964475
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64118145
60Bladder cancer_Homo sapiens_hsa052190.63599704
61Fatty acid degradation_Homo sapiens_hsa000710.63040290
62Salivary secretion_Homo sapiens_hsa049700.61779601
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61537096
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60434003
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58529437
66PPAR signaling pathway_Homo sapiens_hsa033200.58318270
67Axon guidance_Homo sapiens_hsa043600.57466394
68Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56817906
69Peroxisome_Homo sapiens_hsa041460.55067088
70Complement and coagulation cascades_Homo sapiens_hsa046100.53280338
71One carbon pool by folate_Homo sapiens_hsa006700.51561656
72Type II diabetes mellitus_Homo sapiens_hsa049300.49865316
73cAMP signaling pathway_Homo sapiens_hsa040240.49562202
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48935910
75Hedgehog signaling pathway_Homo sapiens_hsa043400.48631044
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46139697
77Melanogenesis_Homo sapiens_hsa049160.46056657
78Dorso-ventral axis formation_Homo sapiens_hsa043200.46032702
79Cholinergic synapse_Homo sapiens_hsa047250.45145963
80N-Glycan biosynthesis_Homo sapiens_hsa005100.44838162
81Retinol metabolism_Homo sapiens_hsa008300.44235033
82Cardiac muscle contraction_Homo sapiens_hsa042600.44091970
83Pancreatic secretion_Homo sapiens_hsa049720.43654535
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42446525
85Amphetamine addiction_Homo sapiens_hsa050310.42117100
86Ras signaling pathway_Homo sapiens_hsa040140.39771867
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39362670
88African trypanosomiasis_Homo sapiens_hsa051430.38908765
89Dilated cardiomyopathy_Homo sapiens_hsa054140.38389274
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37982608
91TNF signaling pathway_Homo sapiens_hsa046680.37258964
92VEGF signaling pathway_Homo sapiens_hsa043700.36815779
93Fatty acid metabolism_Homo sapiens_hsa012120.36799783
94Starch and sucrose metabolism_Homo sapiens_hsa005000.36080188
95Hippo signaling pathway_Homo sapiens_hsa043900.35503458
96Rap1 signaling pathway_Homo sapiens_hsa040150.32972675
97Dopaminergic synapse_Homo sapiens_hsa047280.32953417
98Estrogen signaling pathway_Homo sapiens_hsa049150.32663644
99Arginine and proline metabolism_Homo sapiens_hsa003300.31633629
100RNA polymerase_Homo sapiens_hsa030200.31056875

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