ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.99510014
2	branching involved in labyrinthine layer morphogenesis (GO:0060670)	5.05825907
3	DNA deamination (GO:0045006)	4.46309757
4	regulation of sequestering of triglyceride (GO:0010889)	4.23753927
5	preassembly of GPI anchor in ER membrane (GO:0016254)	4.11763115
6	DNA methylation involved in gamete generation (GO:0043046)	4.05410100
7	male meiosis I (GO:0007141)	4.00594011
8	cell proliferation in forebrain (GO:0021846)	3.91346577
9	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.86882972
10	prostate gland growth (GO:0060736)	3.82233049
11	synapsis (GO:0007129)	3.80616903
12	positive regulation of fatty acid oxidation (GO:0046321)	3.68434970
13	negative regulation of Rho protein signal transduction (GO:0035024)	3.63009182
14	piRNA metabolic process (GO:0034587)	3.62888997
15	sulfation (GO:0051923)	3.61597541
16	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.55153454
17	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.55153454
18	NADH dehydrogenase complex assembly (GO:0010257)	3.55153454
19	somite development (GO:0061053)	3.29271147
20	indolalkylamine metabolic process (GO:0006586)	3.28103167
21	tryptophan catabolic process (GO:0006569)	3.24177785
22	indole-containing compound catabolic process (GO:0042436)	3.24177785
23	indolalkylamine catabolic process (GO:0046218)	3.24177785
24	snRNA transcription (GO:0009301)	3.14506552
25	protein complex biogenesis (GO:0070271)	3.13038796
26	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.02981319
27	negative regulation of mast cell activation (GO:0033004)	2.97255546
28	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	2.91583052
29	white fat cell differentiation (GO:0050872)	2.90502382
30	kynurenine metabolic process (GO:0070189)	2.87581258
31	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.86171694
32	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.86171694
33	regulation of cell proliferation involved in kidney development (GO:1901722)	2.83922997
34	spindle assembly involved in mitosis (GO:0090307)	2.82429729
35	meiosis I (GO:0007127)	2.81321986
36	tryptophan metabolic process (GO:0006568)	2.80469036
37	kidney morphogenesis (GO:0060993)	2.76525967
38	negative regulation of systemic arterial blood pressure (GO:0003085)	2.76080210
39	chromosome organization involved in meiosis (GO:0070192)	2.76057576
40	regulation of mesoderm development (GO:2000380)	2.75400670
41	regulation of memory T cell differentiation (GO:0043380)	2.75223209
42	mitochondrial respiratory chain complex assembly (GO:0033108)	2.73055639
43	regulation of collateral sprouting (GO:0048670)	2.72051774
44	dentate gyrus development (GO:0021542)	2.71219050
45	adaptation of signaling pathway (GO:0023058)	2.70936956
46	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.70516531
47	mitochondrion morphogenesis (GO:0070584)	2.69245696
48	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.68610650
49	protein polyglutamylation (GO:0018095)	2.67651004
50	neuronal action potential (GO:0019228)	2.67013009
51	water-soluble vitamin biosynthetic process (GO:0042364)	2.65404821
52	positive regulation of potassium ion transmembrane transport (GO:1901381)	2.64314070
53	regulation of action potential (GO:0098900)	2.64236327
54	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	2.64036946
55	negative regulation of telomerase activity (GO:0051974)	2.62787295
56	fucose catabolic process (GO:0019317)	2.60723661
57	L-fucose metabolic process (GO:0042354)	2.60723661
58	L-fucose catabolic process (GO:0042355)	2.60723661
59	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	2.60517449
60	indole-containing compound metabolic process (GO:0042430)	2.55235343
61	endoderm formation (GO:0001706)	2.54887626
62	membrane repolarization during action potential (GO:0086011)	2.52137780
63	response to lipoprotein particle (GO:0055094)	2.51422526
64	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.48162853
65	negative regulation of interleukin-1 beta production (GO:0032691)	2.47713225
66	peristalsis (GO:0030432)	2.47536990
67	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.47274438
68	activated T cell proliferation (GO:0050798)	2.46886341
69	ovulation cycle (GO:0042698)	2.45071662
70	spinal cord development (GO:0021510)	2.44888076
71	negative regulation of interleukin-1 production (GO:0032692)	2.44202423
72	positive regulation of defense response to virus by host (GO:0002230)	2.44146656
73	regulation of hippo signaling (GO:0035330)	2.43541386
74	regulation of syncytium formation by plasma membrane fusion (GO:0060142)	2.43111023
75	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	2.41902621
76	synaptic transmission, cholinergic (GO:0007271)	2.41149210
77	cardiovascular system development (GO:0072358)	2.39733153
78	male meiosis (GO:0007140)	2.39560196
79	cellular response to ATP (GO:0071318)	2.39421394
80	GPI anchor metabolic process (GO:0006505)	2.37900438
81	positive regulation of steroid hormone secretion (GO:2000833)	2.37766672
82	multicellular organism reproduction (GO:0032504)	2.37508600
83	interkinetic nuclear migration (GO:0022027)	2.37271747
84	synaptonemal complex assembly (GO:0007130)	2.36374261
85	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.35410353
86	detection of light stimulus involved in sensory perception (GO:0050962)	2.34866805
87	detection of light stimulus involved in visual perception (GO:0050908)	2.34866805
88	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.34074536
89	serotonin metabolic process (GO:0042428)	2.33863854
90	cellular response to exogenous dsRNA (GO:0071360)	2.30006302
91	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.29905618
92	spinal cord motor neuron differentiation (GO:0021522)	2.28964890
93	positive regulation of cAMP-mediated signaling (GO:0043950)	2.28900278
94	gamma-aminobutyric acid transport (GO:0015812)	2.26861750
95	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.26253578
96	synaptonemal complex organization (GO:0070193)	2.26228301
97	primary amino compound metabolic process (GO:1901160)	2.24700475
98	positive regulation of CREB transcription factor activity (GO:0032793)	2.24625665
99	negative regulation of ERK1 and ERK2 cascade (GO:0070373)	2.24157274
100	serine family amino acid catabolic process (GO:0009071)	2.22124427

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.75782449
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.54111568
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.54815372
4	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.54234506
5	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.28672782
6	VDR_22108803_ChIP-Seq_LS180_Human	2.23441023
7	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.10733688
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.08114401
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.98816279
10	IRF1_19129219_ChIP-ChIP_H3396_Human	1.94200525
11	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.90768914
12	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.86354996
13	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.83420397
14	ER_23166858_ChIP-Seq_MCF-7_Human	1.81681079
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.80376513
16	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.77756921
17	REST_21632747_ChIP-Seq_MESCs_Mouse	1.75421525
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.74356980
19	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.73043560
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.71050368
21	IGF1R_20145208_ChIP-Seq_DFB_Human	1.66161649
22	DROSHA_22980978_ChIP-Seq_HELA_Human	1.64820285
23	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.64578143
24	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.63866881
25	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.62634786
26	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.59112769
27	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.59055766
28	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.55074625
29	RNF2_27304074_Chip-Seq_NSC_Mouse	1.54847075
30	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.53490370
31	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.48541422
32	FUS_26573619_Chip-Seq_HEK293_Human	1.45521452
33	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.45508211
34	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.44795002
35	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.41392515
36	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.41075924
37	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.39425023
38	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.34831357
39	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.34254461
40	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.33728089
41	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.33284804
42	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.33284804
43	AR_21572438_ChIP-Seq_LNCaP_Human	1.32722914
44	BCAT_22108803_ChIP-Seq_LS180_Human	1.30243816
45	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.29096152
46	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.28600823
47	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.26403730
48	P300_19829295_ChIP-Seq_ESCs_Human	1.25235664
49	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.25094151
50	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.25081052
51	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.23816018
52	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.21942808
53	TAF15_26573619_Chip-Seq_HEK293_Human	1.20927455
54	TCF4_23295773_ChIP-Seq_U87_Human	1.20328642
55	STAT3_23295773_ChIP-Seq_U87_Human	1.20159493
56	EWS_26573619_Chip-Seq_HEK293_Human	1.20062423
57	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.19727009
58	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.19283970
59	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.16174272
60	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.15690642
61	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.15606744
62	TP53_22573176_ChIP-Seq_HFKS_Human	1.13988376
63	TP53_16413492_ChIP-PET_HCT116_Human	1.13756557
64	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.13696790
65	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.13498712
66	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.08286753
67	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.08286753
68	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.06713154
69	RUNX_20019798_ChIP-Seq_JUKART_Human	1.06369534
70	AR_25329375_ChIP-Seq_VCAP_Human	1.06204334
71	SMAD4_21799915_ChIP-Seq_A2780_Human	1.06079970
72	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.05411028
73	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05379746
74	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.04679108
75	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.03661123
76	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.02753066
77	NANOG_20526341_ChIP-Seq_ESCs_Human	1.02425679
78	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.02285016
79	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.02072985
80	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.01883088
81	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.01883088
82	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.01605725
83	RAC3_21632823_ChIP-Seq_H3396_Human	1.00938217
84	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.99460034
85	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.98851855
86	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.98318651
87	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.98106245
88	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.98035257
89	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.97990614
90	NCOR_22424771_ChIP-Seq_293T_Human	0.97231015
91	AHR_22903824_ChIP-Seq_MCF-7_Human	0.96248526
92	ERA_21632823_ChIP-Seq_H3396_Human	0.96138392
93	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.96078519
94	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.95717402
95	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.95036793
96	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94447164
97	RUNX2_22187159_ChIP-Seq_PCA_Human	0.94271533
98	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.93658993
99	MYC_19829295_ChIP-Seq_ESCs_Human	0.92378914
100	SMRT_27268052_Chip-Seq_Bcells_Human	0.91860379

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005670_abnormal_white_adipose	3.97561557
2	MP0003724_increased_susceptibility_to	3.40301930
3	MP0003646_muscle_fatigue	3.36036111
4	MP0002653_abnormal_ependyma_morphology	3.32099688
5	MP0006292_abnormal_olfactory_placode	3.02174477
6	MP0001485_abnormal_pinna_reflex	2.85174433
7	MP0008877_abnormal_DNA_methylation	2.83145555
8	MP0005646_abnormal_pituitary_gland	2.47384150
9	MP0004130_abnormal_muscle_cell	2.42037874
10	MP0005174_abnormal_tail_pigmentation	2.12958141
11	MP0001986_abnormal_taste_sensitivity	2.07617816
12	MP0002160_abnormal_reproductive_system	1.98322055
13	MP0003195_calcinosis	1.97088534
14	MP0003878_abnormal_ear_physiology	1.89589530
15	MP0005377_hearing/vestibular/ear_phenot	1.89589530
16	MP0003119_abnormal_digestive_system	1.88171517
17	MP0009379_abnormal_foot_pigmentation	1.87130999
18	MP0000631_abnormal_neuroendocrine_gland	1.81821397
19	MP0002277_abnormal_respiratory_mucosa	1.80884325
20	MP0008872_abnormal_physiological_respon	1.73553227
21	MP0002876_abnormal_thyroid_physiology	1.68633610
22	MP0002163_abnormal_gland_morphology	1.66529413
23	MP0000569_abnormal_digit_pigmentation	1.64470792
24	MP0005389_reproductive_system_phenotype	1.64222922
25	MP0004885_abnormal_endolymph	1.64196371
26	MP0000049_abnormal_middle_ear	1.61930599
27	MP0002837_dystrophic_cardiac_calcinosis	1.57881311
28	MP0002102_abnormal_ear_morphology	1.55345132
29	MP0003787_abnormal_imprinting	1.55162632
30	MP0005551_abnormal_eye_electrophysiolog	1.52599020
31	MP0002928_abnormal_bile_duct	1.49916847
32	MP0001968_abnormal_touch/_nociception	1.47465154
33	MP0003136_yellow_coat_color	1.47027234
34	MP0000516_abnormal_urinary_system	1.46911494
35	MP0005367_renal/urinary_system_phenotyp	1.46911494
36	MP0000013_abnormal_adipose_tissue	1.45080460
37	MP0004142_abnormal_muscle_tone	1.42180477
38	MP0004145_abnormal_muscle_electrophysio	1.36069005
39	MP0003011_delayed_dark_adaptation	1.35536514
40	MP0009745_abnormal_behavioral_response	1.33428426
41	MP0003879_abnormal_hair_cell	1.32893543
42	MP0000015_abnormal_ear_pigmentation	1.29057505
43	MP0008789_abnormal_olfactory_epithelium	1.28359544
44	MP0001486_abnormal_startle_reflex	1.27032985
45	MP0004133_heterotaxia	1.25432869
46	MP0002272_abnormal_nervous_system	1.25075530
47	MP0003890_abnormal_embryonic-extraembry	1.24696372
48	MP0009046_muscle_twitch	1.21844240
49	MP0003315_abnormal_perineum_morphology	1.21251045
50	MP0002638_abnormal_pupillary_reflex	1.17589038
51	MP0001919_abnormal_reproductive_system	1.17348776
52	MP0003938_abnormal_ear_development	1.17255974
53	MP0000427_abnormal_hair_cycle	1.16981418
54	MP0002138_abnormal_hepatobiliary_system	1.14214570
55	MP0002735_abnormal_chemical_nociception	1.10456462
56	MP0009765_abnormal_xenobiotic_induced	1.06203181
57	MP0000470_abnormal_stomach_morphology	1.05154620
58	MP0002095_abnormal_skin_pigmentation	1.01191913
59	MP0002064_seizures	0.99545509
60	MP0005084_abnormal_gallbladder_morpholo	0.96934816
61	MP0005379_endocrine/exocrine_gland_phen	0.96812261
62	MP0002909_abnormal_adrenal_gland	0.95292875
63	MP0009053_abnormal_anal_canal	0.95113639
64	MP0006072_abnormal_retinal_apoptosis	0.95069392
65	MP0001963_abnormal_hearing_physiology	0.94554285
66	MP0001800_abnormal_humoral_immune	0.91186002
67	MP0001970_abnormal_pain_threshold	0.90075041
68	MP0003635_abnormal_synaptic_transmissio	0.88214780
69	MP0001663_abnormal_digestive_system	0.88176160
70	MP0003283_abnormal_digestive_organ	0.86774862
71	MP0005387_immune_system_phenotype	0.84853272
72	MP0001790_abnormal_immune_system	0.84853272
73	MP0001440_abnormal_grooming_behavior	0.84822237
74	MP0002572_abnormal_emotion/affect_behav	0.84815257
75	MP0002733_abnormal_thermal_nociception	0.84440171
76	MP0005195_abnormal_posterior_eye	0.84436889
77	MP0000026_abnormal_inner_ear	0.84294453
78	MP0004381_abnormal_hair_follicle	0.83613497
79	MP0005671_abnormal_response_to	0.83505265
80	MP0005253_abnormal_eye_physiology	0.83010081
81	MP0002736_abnormal_nociception_after	0.82674372
82	MP0002751_abnormal_autonomic_nervous	0.82326663
83	MP0002210_abnormal_sex_determination	0.81985433
84	MP0000230_abnormal_systemic_arterial	0.81187269
85	MP0003937_abnormal_limbs/digits/tail_de	0.80502970
86	MP0004742_abnormal_vestibular_system	0.78484260
87	MP0005394_taste/olfaction_phenotype	0.77421270
88	MP0005499_abnormal_olfactory_system	0.77421270
89	MP0000685_abnormal_immune_system	0.74869916
90	MP0001765_abnormal_ion_homeostasis	0.74731385
91	MP0003936_abnormal_reproductive_system	0.73056785
92	MP0003656_abnormal_erythrocyte_physiolo	0.72965447
93	MP0008995_early_reproductive_senescence	0.71602529
94	MP0002723_abnormal_immune_serum	0.70725097
95	MP0001944_abnormal_pancreas_morphology	0.70128708
96	MP0000778_abnormal_nervous_system	0.69986512
97	MP0005645_abnormal_hypothalamus_physiol	0.69161688
98	MP0002063_abnormal_learning/memory/cond	0.68321603
99	MP0009764_decreased_sensitivity_to	0.67007280
100	MP0008057_abnormal_DNA_replication	0.65403807

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Short 1st metacarpal (HP:0010034)	4.54491636
2	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	4.54491636
3	Abnormality of the 1st metacarpal (HP:0010009)	3.98086831
4	Stenosis of the external auditory canal (HP:0000402)	3.63477142
5	Congenital stationary night blindness (HP:0007642)	3.63190325
6	Genetic anticipation (HP:0003743)	3.54797047
7	Ectopic kidney (HP:0000086)	3.36959229
8	Absent thumb (HP:0009777)	3.23736205
9	Short phalanx of the thumb (HP:0009660)	3.21290473
10	Pendular nystagmus (HP:0012043)	3.13249053
11	Pancreatic cysts (HP:0001737)	3.09437062
12	Short hallux (HP:0010109)	3.08107291
13	Carpal bone hypoplasia (HP:0001498)	3.07678049
14	Pancreatic fibrosis (HP:0100732)	2.97860325
15	Abnormality of midbrain morphology (HP:0002418)	2.96568217
16	Molar tooth sign on MRI (HP:0002419)	2.96568217
17	Abolished electroretinogram (ERG) (HP:0000550)	2.93014924
18	Progressive cerebellar ataxia (HP:0002073)	2.91232049
19	Aplasia/Hypoplasia of the hallux (HP:0008362)	2.87233302
20	Abnormality of the renal collecting system (HP:0004742)	2.82358356
21	Congenital sensorineural hearing impairment (HP:0008527)	2.77866861
22	Nephronophthisis (HP:0000090)	2.76830767
23	True hermaphroditism (HP:0010459)	2.75986703
24	Osteomalacia (HP:0002749)	2.73462759
25	Abnormality of the nasal septum (HP:0000419)	2.57769198
26	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.56856572
27	Panhypogammaglobulinemia (HP:0003139)	2.50328032
28	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.49548042
29	Absent/shortened dynein arms (HP:0200106)	2.49548042
30	Abnormality of DNA repair (HP:0003254)	2.49336025
31	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	2.46453866
32	Chorioretinal atrophy (HP:0000533)	2.45390475
33	Duplicated collecting system (HP:0000081)	2.42489870
34	Rectal fistula (HP:0100590)	2.42119547
35	Rectovaginal fistula (HP:0000143)	2.42119547
36	Bony spicule pigmentary retinopathy (HP:0007737)	2.41509403
37	Polydipsia (HP:0001959)	2.37079041
38	Abnormal drinking behavior (HP:0030082)	2.37079041
39	Abnormality of the renal medulla (HP:0100957)	2.36907936
40	Abnormal rod and cone electroretinograms (HP:0008323)	2.35293692
41	Fused cervical vertebrae (HP:0002949)	2.33334735
42	Hematochezia (HP:0002573)	2.21718043
43	Gaze-evoked nystagmus (HP:0000640)	2.21505540
44	Increased corneal curvature (HP:0100692)	2.19833667
45	Keratoconus (HP:0000563)	2.19833667
46	Intestinal fistula (HP:0100819)	2.17961196
47	Decreased subcutaneous fat (HP:0001002)	2.17018189
48	Synostosis of carpal bones (HP:0005048)	2.16422093
49	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.14972006
50	Methylmalonic aciduria (HP:0012120)	2.11264834
51	Decreased circulating renin level (HP:0003351)	2.11169868
52	Toxemia of pregnancy (HP:0100603)	2.08439108
53	Stomach cancer (HP:0012126)	2.07667918
54	Methylmalonic acidemia (HP:0002912)	2.07268797
55	Hyperventilation (HP:0002883)	2.02211494
56	Attenuation of retinal blood vessels (HP:0007843)	2.01290766
57	Tachypnea (HP:0002789)	2.01158443
58	Concave nail (HP:0001598)	2.00602261
59	Congenital, generalized hypertrichosis (HP:0004540)	2.00322953
60	Short thumb (HP:0009778)	1.99769021
61	Wide intermamillary distance (HP:0006610)	1.98696741
62	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.98360742
63	Broad-based gait (HP:0002136)	1.97894006
64	Reticulocytopenia (HP:0001896)	1.97260709
65	Cystic liver disease (HP:0006706)	1.95551366
66	Vertebral fusion (HP:0002948)	1.94711157
67	Hypoplastic iliac wings (HP:0002866)	1.94499798
68	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.93589025
69	Clumsiness (HP:0002312)	1.92748722
70	Hypoplasia of the ulna (HP:0003022)	1.92276570
71	Severe muscular hypotonia (HP:0006829)	1.89187394
72	Status epilepticus (HP:0002133)	1.89023163
73	Progressive inability to walk (HP:0002505)	1.86932142
74	Inability to walk (HP:0002540)	1.86095417
75	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.85138509
76	Oligomenorrhea (HP:0000876)	1.84199156
77	Horseshoe kidney (HP:0000085)	1.82621916
78	Colon cancer (HP:0003003)	1.81324219
79	Vaginal fistula (HP:0004320)	1.80205138
80	Pallor (HP:0000980)	1.79920446
81	Aplasia/Hypoplasia of the patella (HP:0006498)	1.79319550
82	Abnormality of the renal cortex (HP:0011035)	1.77628182
83	Ventricular fibrillation (HP:0001663)	1.77526243
84	Rib fusion (HP:0000902)	1.76411435
85	Optic nerve coloboma (HP:0000588)	1.75895107
86	Medial flaring of the eyebrow (HP:0010747)	1.75357536
87	Abnormal respiratory epithelium morphology (HP:0012253)	1.75318723
88	Abnormal respiratory motile cilium morphology (HP:0005938)	1.75318723
89	Decreased central vision (HP:0007663)	1.73823124
90	Maternal diabetes (HP:0009800)	1.72453026
91	Rectal prolapse (HP:0002035)	1.71680735
92	Hip dysplasia (HP:0001385)	1.71150279
93	Tubular atrophy (HP:0000092)	1.70849156
94	Type II lissencephaly (HP:0007260)	1.70619030
95	Abnormal ciliary motility (HP:0012262)	1.70319069
96	Hypoplasia of the radius (HP:0002984)	1.70263386
97	Enlarged kidneys (HP:0000105)	1.68272530
98	Lipid accumulation in hepatocytes (HP:0006561)	1.68154928
99	Polyuria (HP:0000103)	1.67950447
100	Agitation (HP:0000713)	1.66547521

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.72514335
2	ADRBK2	3.84242636
3	GRK1	3.29205544
4	ERN1	2.95285876
5	TAOK3	2.51749313
6	MAP2K2	2.44925296
7	WNK4	2.22984742
8	BMPR1B	2.07403749
9	TLK1	1.87536860
10	ZAK	1.83456908
11	ACVR1B	1.80300058
12	WNK3	1.76450156
13	MAPK13	1.74433790
14	NLK	1.72753761
15	DAPK2	1.65888364
16	ADRBK1	1.63385338
17	STK11	1.60962823
18	INSRR	1.60175095
19	MAP2K1	1.56133072
20	MAP4K2	1.44687223
21	IKBKE	1.44550230
22	TXK	1.42816828
23	MAP2K6	1.40661229
24	PINK1	1.38723940
25	CASK	1.27390689
26	TNK2	1.21640896
27	IRAK4	1.19452894
28	PNCK	1.19180887
29	SYK	1.18372220
30	MAP4K1	1.17695091
31	DYRK2	1.17520309
32	NUAK1	1.15177870
33	MAP2K4	1.14087854
34	MAP2K3	1.11689698
35	IKBKB	1.09119055
36	MAPK15	1.05215457
37	GRK6	1.04669465
38	IRAK2	1.04460214
39	OXSR1	1.02110879
40	STK39	1.01955040
41	MAP3K4	0.95784390
42	RPS6KA6	0.91050843
43	DYRK3	0.84906403
44	CSK	0.82740722
45	TEC	0.81998805
46	BLK	0.80321245
47	CDK19	0.80012347
48	PTK2B	0.79631951
49	CDK9	0.75550122
50	SGK2	0.74637531
51	LYN	0.73580677
52	TAOK1	0.71408083
53	MKNK2	0.69973784
54	WNK1	0.69970876
55	PRKD2	0.69948634
56	RPS6KA5	0.68924220
57	SIK2	0.68762309
58	PRKCZ	0.68743082
59	NTRK3	0.67950668
60	MAP2K7	0.66535408
61	GRK7	0.66452189
62	RIPK4	0.66334092
63	FGFR2	0.64312769
64	PIK3CA	0.63547410
65	KIT	0.61105484
66	MELK	0.60807965
67	PRKCQ	0.60611466
68	PAK3	0.60070756
69	PRKCG	0.59870466
70	MUSK	0.58886838
71	MARK2	0.57290320
72	LCK	0.57090061
73	BTK	0.57064705
74	DYRK1A	0.56356470
75	PRKCI	0.55550513
76	SGK223	0.54068762
77	SGK494	0.54068762
78	PLK2	0.53386796
79	CAMK1	0.53142975
80	PRKCE	0.51939984
81	PRKACA	0.48921693
82	PIM1	0.48085568
83	GRK5	0.47841060
84	RPS6KL1	0.46653126
85	RPS6KC1	0.46653126
86	CSNK1D	0.46157794
87	ITK	0.46118320
88	NTRK2	0.46008703
89	MARK3	0.45744446
90	CHUK	0.45561012
91	ERBB2	0.45232780
92	MAPK3	0.45032942
93	NME1	0.44134990
94	CSNK1A1	0.41695713
95	CAMKK2	0.41545776
96	HCK	0.41452704
97	HIPK2	0.40138187
98	IRAK1	0.39426929
99	CSNK1A1L	0.39390221
100	CSNK1G2	0.37744987

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.13604378
2	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.75503459
3	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.58952579
4	Phototransduction_Homo sapiens_hsa04744	2.44660507
5	Nicotine addiction_Homo sapiens_hsa05033	2.31895504
6	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.29881252
7	Sulfur relay system_Homo sapiens_hsa04122	2.24428393
8	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.24048953
9	Linoleic acid metabolism_Homo sapiens_hsa00591	1.93438069
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.81674390
11	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.77968410
12	Morphine addiction_Homo sapiens_hsa05032	1.77291492
13	Olfactory transduction_Homo sapiens_hsa04740	1.66248758
14	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.65643795
15	Primary immunodeficiency_Homo sapiens_hsa05340	1.65636833
16	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.64153380
17	Selenocompound metabolism_Homo sapiens_hsa00450	1.63598115
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.60193912
19	Nitrogen metabolism_Homo sapiens_hsa00910	1.54772988
20	Homologous recombination_Homo sapiens_hsa03440	1.54088450
21	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.51788980
22	Ribosome_Homo sapiens_hsa03010	1.45501206
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.45259286
24	Taste transduction_Homo sapiens_hsa04742	1.42363966
25	Asthma_Homo sapiens_hsa05310	1.32904857
26	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.25013228
27	Circadian entrainment_Homo sapiens_hsa04713	1.24359988
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.19406731
29	Serotonergic synapse_Homo sapiens_hsa04726	1.15975419
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.14899484
31	Glutamatergic synapse_Homo sapiens_hsa04724	1.13517467
32	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.09854233
33	Caffeine metabolism_Homo sapiens_hsa00232	1.07556926
34	ABC transporters_Homo sapiens_hsa02010	1.05162792
35	Glycerolipid metabolism_Homo sapiens_hsa00561	1.03369100
36	GABAergic synapse_Homo sapiens_hsa04727	1.02435062
37	Insulin secretion_Homo sapiens_hsa04911	1.02402595
38	Graft-versus-host disease_Homo sapiens_hsa05332	1.01019681
39	Type I diabetes mellitus_Homo sapiens_hsa04940	0.97937388
40	Cholinergic synapse_Homo sapiens_hsa04725	0.97416885
41	Basal transcription factors_Homo sapiens_hsa03022	0.94870519
42	Regulation of autophagy_Homo sapiens_hsa04140	0.94010602
43	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.92853176
44	Chemical carcinogenesis_Homo sapiens_hsa05204	0.91124798
45	Ether lipid metabolism_Homo sapiens_hsa00565	0.90775526
46	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.90673790
47	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.87366326
48	Calcium signaling pathway_Homo sapiens_hsa04020	0.87087502
49	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.84483717
50	Sulfur metabolism_Homo sapiens_hsa00920	0.82634369
51	Basal cell carcinoma_Homo sapiens_hsa05217	0.82458500
52	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.80200554
53	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.79049446
54	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.78249936
55	Allograft rejection_Homo sapiens_hsa05330	0.76682281
56	Oxidative phosphorylation_Homo sapiens_hsa00190	0.76360657
57	Retinol metabolism_Homo sapiens_hsa00830	0.75253641
58	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.75162329
59	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.73104375
60	Renin-angiotensin system_Homo sapiens_hsa04614	0.72923405
61	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.71361503
62	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.70827563
63	cAMP signaling pathway_Homo sapiens_hsa04024	0.68703302
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.67983977
65	RNA polymerase_Homo sapiens_hsa03020	0.67230592
66	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.67042510
67	Butanoate metabolism_Homo sapiens_hsa00650	0.64380949
68	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.64162076
69	Collecting duct acid secretion_Homo sapiens_hsa04966	0.62874533
70	Alzheimers disease_Homo sapiens_hsa05010	0.61242384
71	Type II diabetes mellitus_Homo sapiens_hsa04930	0.61208611
72	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.60609489
73	Salivary secretion_Homo sapiens_hsa04970	0.60192888
74	Axon guidance_Homo sapiens_hsa04360	0.59840909
75	Parkinsons disease_Homo sapiens_hsa05012	0.58730884
76	Gastric acid secretion_Homo sapiens_hsa04971	0.57939582
77	Huntingtons disease_Homo sapiens_hsa05016	0.57817731
78	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.57326167
79	Dopaminergic synapse_Homo sapiens_hsa04728	0.56753939
80	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.55528611
81	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.55469819
82	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.53565043
83	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.52188683
84	Cardiac muscle contraction_Homo sapiens_hsa04260	0.50883123
85	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.48056200
86	MAPK signaling pathway_Homo sapiens_hsa04010	0.45646309
87	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.45497489
88	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.44906784
89	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.44482197
90	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.42084202
91	Cocaine addiction_Homo sapiens_hsa05030	0.40566878
92	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.39544414
93	Leishmaniasis_Homo sapiens_hsa05140	0.39288757
94	Fat digestion and absorption_Homo sapiens_hsa04975	0.39199935
95	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.38999850
96	Tuberculosis_Homo sapiens_hsa05152	0.38444142
97	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.38325335
98	African trypanosomiasis_Homo sapiens_hsa05143	0.37879079
99	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.37393477
100	Osteoclast differentiation_Homo sapiens_hsa04380	0.36963164

CICP27

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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