CICP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1germ cell migration (GO:0008354)9.37030340
2positive regulation of catecholamine secretion (GO:0033605)9.23251391
3positive regulation of calcium ion import (GO:0090280)8.67032563
4negative regulation of norepinephrine secretion (GO:0010700)7.56232013
5positive regulation of monocyte chemotaxis (GO:0090026)6.97668395
6phenylpropanoid metabolic process (GO:0009698)6.80517805
7regulation of gonadotropin secretion (GO:0032276)6.20526391
8locomotory exploration behavior (GO:0035641)6.06481616
9glucocorticoid biosynthetic process (GO:0006704)5.88894309
10glutathione biosynthetic process (GO:0006750)5.80574912
11regulation of cellular extravasation (GO:0002691)5.61114667
12regulation of monocyte chemotaxis (GO:0090025)5.46586731
13positive regulation of amine transport (GO:0051954)5.33268107
14positive regulation of odontogenesis (GO:0042482)5.32060895
15nonribosomal peptide biosynthetic process (GO:0019184)5.28024911
16induction of positive chemotaxis (GO:0050930)5.21747542
17regulation of glucocorticoid secretion (GO:2000849)5.20696026
18complement activation, alternative pathway (GO:0006957)5.02088949
19positive regulation of digestive system process (GO:0060456)5.02036814
20regulation of monocyte differentiation (GO:0045655)4.98974311
21positive regulation of amino acid transport (GO:0051957)4.98625810
22parturition (GO:0007567)4.98325723
23regulation of calcium ion import (GO:0090279)4.86229274
24imidazole-containing compound metabolic process (GO:0052803)4.85742855
25regulation of corticosteroid hormone secretion (GO:2000846)4.85406216
26positive regulation of steroid hormone secretion (GO:2000833)4.75338471
27response to corticosterone (GO:0051412)4.70017973
28negative regulation of catecholamine secretion (GO:0033604)4.61604206
29regulation of axon extension involved in axon guidance (GO:0048841)4.59387788
30tooth mineralization (GO:0034505)4.59266048
31ether metabolic process (GO:0018904)4.58799102
32GDP-mannose metabolic process (GO:0019673)4.48416061
33hypothalamus development (GO:0021854)4.47056541
34triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.43921317
35RNA destabilization (GO:0050779)4.37795945
36regulation of axon guidance (GO:1902667)4.36073161
37regulation of dopamine secretion (GO:0014059)4.33747278
38negative regulation of circadian rhythm (GO:0042754)4.21876034
39negative regulation of leukocyte migration (GO:0002686)4.19546420
40negative regulation of amine transport (GO:0051953)4.05842411
41response to mineralocorticoid (GO:0051385)4.02205404
42adenosine receptor signaling pathway (GO:0001973)3.99168575
43synaptic transmission, dopaminergic (GO:0001963)3.97923954
443-UTR-mediated mRNA stabilization (GO:0070935)3.94539782
45regulation of circadian sleep/wake cycle (GO:0042749)3.89757663
46regulation of circadian sleep/wake cycle, sleep (GO:0045187)3.89757663
47peptidyl-glutamic acid carboxylation (GO:0017187)3.89113294
48protein carboxylation (GO:0018214)3.89113294
49positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.87966883
50negative regulation of translation, ncRNA-mediated (GO:0040033)3.84717083
51regulation of translation, ncRNA-mediated (GO:0045974)3.84717083
52negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.84717083
53positive regulation of protein kinase C signaling (GO:0090037)3.82334689
54circadian sleep/wake cycle process (GO:0022410)3.82198284
55regulation of norepinephrine secretion (GO:0014061)3.81492739
56regulation of phospholipid biosynthetic process (GO:0071071)3.79146843
57regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.75003337
58peptide biosynthetic process (GO:0043043)3.71301126
59regulation of catecholamine secretion (GO:0050433)3.69794296
60negative regulation of amino acid transport (GO:0051956)3.66251291
61positive regulation of circadian rhythm (GO:0042753)3.62475281
62protein retention in ER lumen (GO:0006621)3.60590977
63positive regulation of axon extension (GO:0045773)3.56379021
64regulation of cholesterol biosynthetic process (GO:0045540)3.55310225
65cellular response to dexamethasone stimulus (GO:0071549)3.55246927
664-hydroxyproline metabolic process (GO:0019471)3.51750247
67cellular response to ammonium ion (GO:0071242)3.47557859
68maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.44672095
69convergent extension (GO:0060026)3.43310457
70glucocorticoid metabolic process (GO:0008211)3.35989289
71response to dexamethasone (GO:0071548)3.33666180
72G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.28191703
73regulation of feeding behavior (GO:0060259)3.21081459
74somite rostral/caudal axis specification (GO:0032525)3.19778426
75positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.19344364
76positive regulation of axonogenesis (GO:0050772)3.13238016
77L-serine transport (GO:0015825)3.09001762
78regulation of steroid hormone secretion (GO:2000831)3.08645232
79regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.05775280
80peptidyl-lysine dimethylation (GO:0018027)3.00637088
81negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902230)2.98892622
82positive regulation of T cell migration (GO:2000406)2.92834238
83DNA strand renaturation (GO:0000733)2.91647731
84nucleoside bisphosphate biosynthetic process (GO:0033866)2.90467381
85purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.90467381
86ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.90467381
87regulation of chemokine-mediated signaling pathway (GO:0070099)2.85603951
88leukotriene biosynthetic process (GO:0019370)2.85185103
89cellular response to ketone (GO:1901655)2.79873372
90regulation of glutamate secretion (GO:0014048)2.79641231
91basement membrane organization (GO:0071711)2.78984493
92receptor recycling (GO:0001881)2.78587315
93motor neuron axon guidance (GO:0008045)2.77805689
94toxin metabolic process (GO:0009404)2.77015764
95proline biosynthetic process (GO:0006561)2.76992173
96exploration behavior (GO:0035640)2.76909445
97cellular response to ATP (GO:0071318)2.75030539
98peptidyl-proline hydroxylation (GO:0019511)2.73641367
99toxin transport (GO:1901998)2.71621784
100sulfur amino acid catabolic process (GO:0000098)2.69614878

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.96183479
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.42384162
3LXR_22292898_ChIP-Seq_THP-1_Human2.99634342
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.69893076
5ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.62016036
6MYC_22102868_ChIP-Seq_BL_Human2.56623219
7TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.54334554
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.47931270
9P68_20966046_ChIP-Seq_HELA_Human2.47398052
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.25962383
11E2F7_22180533_ChIP-Seq_HELA_Human2.20861150
12MAF_26560356_Chip-Seq_TH2_Human2.11319958
13CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.09422410
14KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.08131053
15VDR_24763502_ChIP-Seq_THP-1_Human2.04185447
16BCL6_27268052_Chip-Seq_Bcells_Human1.98072333
17DNAJC2_21179169_ChIP-ChIP_NT2_Human1.97445934
18RACK7_27058665_Chip-Seq_MCF-7_Human1.97199882
19KDM2B_26808549_Chip-Seq_SUP-B15_Human1.94385219
20RXR_22158963_ChIP-Seq_LIVER_Mouse1.92691861
21CTCF_27219007_Chip-Seq_ERYTHROID_Human1.91499184
22SMC4_20622854_ChIP-Seq_HELA_Human1.87913687
23XRN2_22483619_ChIP-Seq_HELA_Human1.86822287
24DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.86374474
25MAF_26560356_Chip-Seq_TH1_Human1.85280705
26BCOR_27268052_Chip-Seq_Bcells_Human1.82729750
27MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.82575234
28ELK3_25401928_ChIP-Seq_HUVEC_Human1.78902451
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.74906710
30SA1_27219007_Chip-Seq_ERYTHROID_Human1.74578899
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.72923615
32RARA_24833708_ChIP-Seq_LIVER_Mouse1.71312477
33GATA1_22025678_ChIP-Seq_K562_Human1.71013459
34CTCF_27219007_Chip-Seq_Bcells_Human1.69660414
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.68663361
36ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.68650006
37TET1_21451524_ChIP-Seq_MESCs_Mouse1.65083523
38KDM2B_26808549_Chip-Seq_DND41_Human1.63609862
39TCF7_22412390_ChIP-Seq_EML_Mouse1.62249323
40CTCF_21964334_Chip-Seq_Bcells_Human1.59046071
41KDM2B_26808549_Chip-Seq_K562_Human1.58946177
42KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.58454116
43KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.58454116
44KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.58454116
45UTX_26944678_Chip-Seq_JUKART_Human1.54009549
46EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.52347089
47RARB_24833708_ChIP-Seq_LIVER_Mouse1.51374091
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50321261
49CLOCK_20551151_ChIP-Seq_293T_Human1.48589115
50PHF8_20622854_ChIP-Seq_HELA_Human1.47729634
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.46078252
52E2F1_20622854_ChIP-Seq_HELA_Human1.46076831
53CTCF_21964334_ChIP-Seq_BJAB-B_Human1.43355932
54SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.38447813
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.34889266
56RUNX1_27514584_Chip-Seq_MCF-7_Human1.34640468
57CREB1_26743006_Chip-Seq_LNCaP_Human1.34378996
58SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33571784
59NCOR1_26117541_ChIP-Seq_K562_Human1.30710516
60PPARA_22158963_ChIP-Seq_LIVER_Mouse1.30692762
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26665327
62CIITA_25753668_ChIP-Seq_RAJI_Human1.26472418
63ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26286915
64KDM2B_26808549_Chip-Seq_JURKAT_Human1.26094721
65SA1_27219007_Chip-Seq_Bcells_Human1.25751569
66RXRA_24833708_ChIP-Seq_LIVER_Mouse1.25577259
67ELF1_20517297_ChIP-Seq_JURKAT_Human1.23478041
68SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23345447
69FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.22582088
70GATA1_19941827_ChIP-Seq_MEL_Mouse1.21790396
71SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20409760
72E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19767134
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19571075
74DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18195226
75FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16668368
76FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.16441329
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15835931
78SMC3_22415368_ChIP-Seq_MEFs_Mouse1.15769694
79KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15003582
80SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13799692
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13179767
82FOXP1_21924763_ChIP-Seq_HESCs_Human1.12948952
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11384538
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10860811
85BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10120578
86UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05705915
87CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04781187
88CTCF_26484167_Chip-Seq_Bcells_Mouse1.04190684
89RUNX1_22412390_ChIP-Seq_EML_Mouse1.04051101
90CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03658891
91NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02544249
92PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02317511
93WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02238047
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02047994
95CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00054265
96RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.99670425
97STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.97838759
98JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.96857863
99CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96125940
100SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95822484

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009278_abnormal_bone_marrow8.21042116
2MP0001986_abnormal_taste_sensitivity4.19732642
3MP0001545_abnormal_hematopoietic_system3.73972712
4MP0005397_hematopoietic_system_phenotyp3.73972712
5MP0005171_absent_coat_pigmentation3.65019513
6MP0004782_abnormal_surfactant_physiolog3.07152204
7MP0003329_amyloid_beta_deposits3.05015925
8MP0003136_yellow_coat_color2.90465019
9MP0003183_abnormal_peptide_metabolism2.53511845
10MP0001919_abnormal_reproductive_system2.51089806
11MP0005670_abnormal_white_adipose2.33213398
12MP0008260_abnormal_autophagy2.14526685
13MP0003303_peritoneal_inflammation2.13030857
14MP0008961_abnormal_basal_metabolism2.12620645
15MP0001661_extended_life_span2.09407366
16MP0004808_abnormal_hematopoietic_stem2.04223192
17MP0008875_abnormal_xenobiotic_pharmacok2.02640238
18MP0001542_abnormal_bone_strength1.93720529
19MP0005423_abnormal_somatic_nervous1.87736888
20MP0003705_abnormal_hypodermis_morpholog1.82478170
21MP0000003_abnormal_adipose_tissue1.82148670
22MP0005375_adipose_tissue_phenotype1.71460059
23MP0005409_darkened_coat_color1.71082751
24MP0000013_abnormal_adipose_tissue1.67253924
25MP0005666_abnormal_adipose_tissue1.67111121
26MP0004858_abnormal_nervous_system1.67084439
27MP0005174_abnormal_tail_pigmentation1.61754751
28MP0005451_abnormal_body_composition1.58865435
29MP0000604_amyloidosis1.58806831
30MP0003632_abnormal_nervous_system1.57803761
31MP0005647_abnormal_sex_gland1.54869490
32MP0003115_abnormal_respiratory_system1.52203382
33MP0001502_abnormal_circadian_rhythm1.48646857
34MP0005365_abnormal_bile_salt1.36423479
35MP0000639_abnormal_adrenal_gland1.32255851
36MP0004272_abnormal_basement_membrane1.32168985
37MP0002249_abnormal_larynx_morphology1.31725597
38MP0003011_delayed_dark_adaptation1.20899495
39MP0002971_abnormal_brown_adipose1.19467252
40MP0002933_joint_inflammation1.14208007
41MP0003453_abnormal_keratinocyte_physiol1.13700081
42MP0010329_abnormal_lipoprotein_level1.13485869
43MP0008057_abnormal_DNA_replication1.10433830
44MP0000681_abnormal_thyroid_gland1.08451869
45MP0000858_altered_metastatic_potential1.07799913
46MP0004947_skin_inflammation1.03863687
47MP0008874_decreased_physiological_sensi1.02543529
48MP0004130_abnormal_muscle_cell1.00820183
49MP0003091_abnormal_cell_migration0.97487345
50MP0000538_abnormal_urinary_bladder0.95605227
51MP0005076_abnormal_cell_differentiation0.94106191
52MP0001849_ear_inflammation0.91805438
53MP0010307_abnormal_tumor_latency0.91416562
54MP0000750_abnormal_muscle_regeneration0.90808467
55MP0002998_abnormal_bone_remodeling0.89464435
56MP0000372_irregular_coat_pigmentation0.89425596
57MP0005332_abnormal_amino_acid0.89374379
58MP0002108_abnormal_muscle_morphology0.87994987
59MP0001915_intracranial_hemorrhage0.86164092
60MP0005389_reproductive_system_phenotype0.85130454
61MP0005503_abnormal_tendon_morphology0.84824238
62MP0001756_abnormal_urination0.84492546
63MP0005187_abnormal_penis_morphology0.83257868
64MP0003111_abnormal_nucleus_morphology0.82324879
65MP0005584_abnormal_enzyme/coenzyme_acti0.81091792
66MP0001851_eye_inflammation0.79417972
67MP0004883_abnormal_blood_vessel0.76603131
68MP0002970_abnormal_white_adipose0.74534269
69MP0004381_abnormal_hair_follicle0.71637592
70MP0001968_abnormal_touch/_nociception0.71201541
71MP0005501_abnormal_skin_physiology0.67580060
72MP0002405_respiratory_system_inflammati0.67014375
73MP0003959_abnormal_lean_body0.66711571
74MP0005083_abnormal_biliary_tract0.65131313
75MP0003718_maternal_effect0.64874400
76MP0000747_muscle_weakness0.63306845
77MP0008775_abnormal_heart_ventricle0.62833555
78MP0005410_abnormal_fertilization0.62462571
79MP0009931_abnormal_skin_appearance0.61031332
80MP0009333_abnormal_splenocyte_physiolog0.59936143
81MP0005058_abnormal_lysosome_morphology0.59776133
82MP0001853_heart_inflammation0.59747364
83MP0000609_abnormal_liver_physiology0.58346764
84MP0002638_abnormal_pupillary_reflex0.58112525
85MP0004134_abnormal_chest_morphology0.57655653
86MP0005551_abnormal_eye_electrophysiolog0.56465505
87MP0005621_abnormal_cell_physiology0.56085028
88MP0001188_hyperpigmentation0.55754828
89MP0000598_abnormal_liver_morphology0.55678379
90MP0003724_increased_susceptibility_to0.55196931
91MP0005448_abnormal_energy_balance0.54217007
92MP0003690_abnormal_glial_cell0.53120958
93MP0000703_abnormal_thymus_morphology0.50813473
94MP0005334_abnormal_fat_pad0.49800429
95MP0005535_abnormal_body_temperature0.49578120
96MP0010094_abnormal_chromosome_stability0.47408362
97MP0000685_abnormal_immune_system0.46994791
98MP0002118_abnormal_lipid_homeostasis0.46451854
99MP0002909_abnormal_adrenal_gland0.46068541
100MP0001765_abnormal_ion_homeostasis0.45170309

Predicted human phenotypes

RankGene SetZ-score
1Widely patent fontanelles and sutures (HP:0004492)5.23668050
2Vaginal fistula (HP:0004320)5.22955666
3Abnormality of the costochondral junction (HP:0000919)5.16102674
4Arterial tortuosity (HP:0005116)5.05583131
5Testicular atrophy (HP:0000029)4.78732833
6Ulnar bowing (HP:0003031)4.69767814
7Metaphyseal cupping (HP:0003021)4.54914624
8Rectovaginal fistula (HP:0000143)4.41841227
9Rectal fistula (HP:0100590)4.41841227
10Intestinal fistula (HP:0100819)4.39594975
11Vascular tortuosity (HP:0004948)4.27174933
12Complement deficiency (HP:0004431)4.11163623
13Vertebral clefting (HP:0008428)4.00062515
14Turricephaly (HP:0000262)3.91207988
15Anteriorly placed anus (HP:0001545)3.84346373
16Congenital stationary night blindness (HP:0007642)3.70026285
17Poikiloderma (HP:0001029)3.68528987
18Thin bony cortex (HP:0002753)3.59633995
19Akinesia (HP:0002304)3.56772839
20Hemorrhage of the eye (HP:0011885)3.49182286
21Abnormality of complement system (HP:0005339)3.43188403
22Osteomalacia (HP:0002749)3.35754633
23Hyperlipoproteinemia (HP:0010980)3.35205029
24Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.32036668
25Wide cranial sutures (HP:0010537)3.22385546
26Choanal stenosis (HP:0000452)3.03458775
27Attenuation of retinal blood vessels (HP:0007843)3.01786246
28Prolonged partial thromboplastin time (HP:0003645)3.01661223
29Joint hemorrhage (HP:0005261)2.99497986
30Rib fusion (HP:0000902)2.85994036
31Abnormality of the intrinsic pathway (HP:0010989)2.70431888
32Facial diplegia (HP:0001349)2.66271039
33Annular pancreas (HP:0001734)2.65470874
34Ankle clonus (HP:0011448)2.63247691
35Myocardial infarction (HP:0001658)2.61320477
36Mesangial abnormality (HP:0001966)2.55046031
37Long toe (HP:0010511)2.48936189
38Growth hormone deficiency (HP:0000824)2.43008401
39Dyschromatopsia (HP:0007641)2.42932242
40Delayed epiphyseal ossification (HP:0002663)2.40833831
41Xanthomatosis (HP:0000991)2.39331821
42Global brain atrophy (HP:0002283)2.38206548
43Hypercholesterolemia (HP:0003124)2.38150502
44Papilledema (HP:0001085)2.34232380
45Bowing of the arm (HP:0006488)2.32785848
46Bowed forearm bones (HP:0003956)2.32785848
47Polycythemia (HP:0001901)2.30419803
48Facial hemangioma (HP:0000329)2.29361787
49Pulmonary artery stenosis (HP:0004415)2.24409914
50Abnormality of the fingertips (HP:0001211)2.24218686
51Rickets (HP:0002748)2.22748133
52Cerebral hemorrhage (HP:0001342)2.21813163
53Coronal craniosynostosis (HP:0004440)2.18828993
54Abnormality of skull ossification (HP:0002703)2.17966993
55Short humerus (HP:0005792)2.16225137
56Abnormal vertebral ossification (HP:0100569)2.13285125
57Aortic regurgitation (HP:0001659)2.10859608
58Choroideremia (HP:0001139)2.10418909
59Joint stiffness (HP:0001387)2.09906140
60Polyphagia (HP:0002591)2.07833369
61Abnormality of the common coagulation pathway (HP:0010990)2.02357384
62Neurofibrillary tangles (HP:0002185)2.01172241
63Soft skin (HP:0000977)2.00651206
64Bony spicule pigmentary retinopathy (HP:0007737)2.00191143
65Premature loss of primary teeth (HP:0006323)1.97089237
66Failure to thrive in infancy (HP:0001531)1.95419643
67Cerebral inclusion bodies (HP:0100314)1.94851680
68Homocystinuria (HP:0002156)1.92440042
69Abnormality of homocysteine metabolism (HP:0010919)1.92440042
70Malnutrition (HP:0004395)1.92131321
71Abnormal epiphyseal ossification (HP:0010656)1.89519618
72Aplasia/hypoplasia of the humerus (HP:0006507)1.89433832
73Aplasia of the musculature (HP:0100854)1.89407870
74Urinary glycosaminoglycan excretion (HP:0003541)1.86609890
75Mucopolysacchariduria (HP:0008155)1.86609890
76Atrioventricular block (HP:0001678)1.85131578
77Decreased central vision (HP:0007663)1.84990272
78Chorioretinal atrophy (HP:0000533)1.81762274
79Deep venous thrombosis (HP:0002625)1.78543027
80Epidermoid cyst (HP:0200040)1.76165442
81Spontaneous hematomas (HP:0007420)1.75650844
82Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.74910895
83Capillary hemangiomas (HP:0005306)1.74363914
84Popliteal pterygium (HP:0009756)1.74246384
85Thin ribs (HP:0000883)1.73594062
86Abnormality of sulfur amino acid metabolism (HP:0004339)1.71511778
87Abnormality of mucopolysaccharide metabolism (HP:0011020)1.71429421
88Abnormality of polysaccharide metabolism (HP:0011012)1.71429421
89Abnormality of glycosaminoglycan metabolism (HP:0004371)1.71429421
90Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.71308246
91Abnormality of alkaline phosphatase activity (HP:0004379)1.68620493
92Peritonitis (HP:0002586)1.68600917
93Fetal akinesia sequence (HP:0001989)1.68085555
94Diminished movement (HP:0002374)1.66004865
95Pathologic fracture (HP:0002756)1.62217338
96Hypercalciuria (HP:0002150)1.62187476
97Lipid accumulation in hepatocytes (HP:0006561)1.61661459
98Keratoconus (HP:0000563)1.61610009
99Increased corneal curvature (HP:0100692)1.61610009
100Supranuclear gaze palsy (HP:0000605)1.61603323

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.73066586
2TRIB33.92334799
3ICK3.91633967
4BRD43.70010907
5ERN13.47344989
6MAP3K63.18835197
7MAP2K32.62988617
8TGFBR22.37680228
9SIK12.04123884
10FGFR41.90486127
11CDK121.87611133
12GRK61.81484003
13MAP2K41.72923075
14TNK21.69233266
15BLK1.66753084
16SIK21.49538844
17PDGFRA1.47519881
18STK38L1.45877317
19STK381.45243100
20AKT31.42421726
21CDK61.38803867
22RPS6KA41.35880100
23ZAP701.34639721
24MOS1.18666354
25EEF2K1.15883355
26PRPF4B1.13604211
27CDK31.13538516
28MAP2K61.12762354
29MUSK1.12316626
30PKN21.09384801
31RET1.08096352
32CDK41.01604403
33CAMK1D1.00922127
34MARK20.99080045
35JAK30.97735991
36IRAK20.97023140
37DAPK20.96308511
38RPS6KA20.87751609
39FGFR30.81009239
40MTOR0.80741871
41NEK60.76411985
42MAP3K70.76352767
43MAP3K140.76135462
44RIPK40.75797471
45TTN0.75588362
46WNK40.75168560
47MAP4K10.74999295
48MAP3K110.74755159
49RPS6KC10.72724218
50RPS6KL10.72724218
51PRKD20.72117432
52MAPK70.71873451
53MAP3K50.71235370
54PDPK10.69828038
55GRK70.68983985
56IKBKE0.68352813
57CAMK1G0.64901737
58PIM20.63962139
59TYRO30.63847094
60MAP2K20.63571072
61MAPK110.62099194
62PRKCZ0.61488185
63TLK10.59749443
64JAK20.59352058
65BCKDK0.59332584
66RPS6KA60.58594837
67BTK0.58531378
68FGFR20.56484126
69PRKD10.53044154
70MAPKAPK20.52470393
71NTRK20.51488767
72EPHB10.50533289
73TAOK20.49222241
74ZAK0.49133559
75ARAF0.48486682
76TYK20.47667535
77GRK50.47552872
78MAPK120.47229682
79CSF1R0.47108346
80SMG10.45763422
81DYRK1B0.44278290
82WNK10.42933132
83CDK70.41667392
84ADRBK10.40466674
85RPS6KA10.40197357
86RPS6KA50.40076594
87TGFBR10.39327309
88FLT30.39314688
89CSK0.39107232
90PKN10.38509938
91MAPK40.36656152
92CDK150.35381797
93TBK10.34966684
94PRKAA10.34803770
95KIT0.34735447
96IRAK30.33783529
97BMX0.33779438
98PRKCG0.32539683
99MAPK80.30731010
100YES10.30304949

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004608.89136598
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004306.58602085
3Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006044.76430151
4Sulfur relay system_Homo sapiens_hsa041223.90976778
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.24010430
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.19021702
7Folate biosynthesis_Homo sapiens_hsa007901.78290955
8Fructose and mannose metabolism_Homo sapiens_hsa000511.46992565
9Prion diseases_Homo sapiens_hsa050201.37786814
10Complement and coagulation cascades_Homo sapiens_hsa046101.34837905
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29465548
12Other glycan degradation_Homo sapiens_hsa005111.28509314
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.25897884
14Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21491323
15Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11045382
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08843633
17Sphingolipid metabolism_Homo sapiens_hsa006001.07639955
18Adipocytokine signaling pathway_Homo sapiens_hsa049201.04200284
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93954812
20Staphylococcus aureus infection_Homo sapiens_hsa051500.90345637
21Intestinal immune network for IgA production_Homo sapiens_hsa046720.85505203
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85024739
23Fanconi anemia pathway_Homo sapiens_hsa034600.84830119
24Arachidonic acid metabolism_Homo sapiens_hsa005900.78481532
25Osteoclast differentiation_Homo sapiens_hsa043800.78278111
26Vitamin digestion and absorption_Homo sapiens_hsa049770.74187344
27Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73323753
28TNF signaling pathway_Homo sapiens_hsa046680.72788958
29Renin-angiotensin system_Homo sapiens_hsa046140.72763493
30PPAR signaling pathway_Homo sapiens_hsa033200.72526129
31Phenylalanine metabolism_Homo sapiens_hsa003600.69033709
32Glutathione metabolism_Homo sapiens_hsa004800.68271584
33Histidine metabolism_Homo sapiens_hsa003400.67093862
34Jak-STAT signaling pathway_Homo sapiens_hsa046300.64532270
35Axon guidance_Homo sapiens_hsa043600.63624562
36Leukocyte transendothelial migration_Homo sapiens_hsa046700.63409499
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63285866
38Prolactin signaling pathway_Homo sapiens_hsa049170.61815660
39Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59553995
40ABC transporters_Homo sapiens_hsa020100.58805567
41Nicotine addiction_Homo sapiens_hsa050330.57049322
42Rheumatoid arthritis_Homo sapiens_hsa053230.53086081
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51546776
44Toll-like receptor signaling pathway_Homo sapiens_hsa046200.51106861
45Hepatitis C_Homo sapiens_hsa051600.49130634
46Choline metabolism in cancer_Homo sapiens_hsa052310.49057274
47Phospholipase D signaling pathway_Homo sapiens_hsa040720.46797204
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46486941
49Malaria_Homo sapiens_hsa051440.46376909
50Lysine degradation_Homo sapiens_hsa003100.46189265
51Base excision repair_Homo sapiens_hsa034100.45524956
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44498162
53Gap junction_Homo sapiens_hsa045400.43349280
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42943914
55Type II diabetes mellitus_Homo sapiens_hsa049300.42788539
56Steroid biosynthesis_Homo sapiens_hsa001000.42230735
57mTOR signaling pathway_Homo sapiens_hsa041500.41571305
58Hepatitis B_Homo sapiens_hsa051610.41569481
59Ovarian steroidogenesis_Homo sapiens_hsa049130.40560966
60Taste transduction_Homo sapiens_hsa047420.39068769
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38861618
62Chemokine signaling pathway_Homo sapiens_hsa040620.37810976
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37649996
64Bile secretion_Homo sapiens_hsa049760.36282339
65VEGF signaling pathway_Homo sapiens_hsa043700.34796756
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34696125
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34543319
68Tyrosine metabolism_Homo sapiens_hsa003500.32855711
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32639206
70B cell receptor signaling pathway_Homo sapiens_hsa046620.32074603
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31673597
72Biosynthesis of amino acids_Homo sapiens_hsa012300.31344557
73HTLV-I infection_Homo sapiens_hsa051660.31337215
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31302790
75AMPK signaling pathway_Homo sapiens_hsa041520.30111801
76Insulin signaling pathway_Homo sapiens_hsa049100.29300863
77Apoptosis_Homo sapiens_hsa042100.29258113
78Acute myeloid leukemia_Homo sapiens_hsa052210.29228936
79Insulin resistance_Homo sapiens_hsa049310.28594939
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.28214697
81Glycerolipid metabolism_Homo sapiens_hsa005610.27782766
82Bladder cancer_Homo sapiens_hsa052190.26600632
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.26238364
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.25899716
85Long-term depression_Homo sapiens_hsa047300.25263753
86Retinol metabolism_Homo sapiens_hsa008300.24992039
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.24929133
88Platelet activation_Homo sapiens_hsa046110.24087642
89Pertussis_Homo sapiens_hsa051330.23805126
90Lysosome_Homo sapiens_hsa041420.23795396
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22524562
92Hematopoietic cell lineage_Homo sapiens_hsa046400.22308650
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22305810
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.21865438
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21412333
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.21217762
97Renal cell carcinoma_Homo sapiens_hsa052110.17611893
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.17404610
99Salmonella infection_Homo sapiens_hsa051320.16585342
100GnRH signaling pathway_Homo sapiens_hsa049120.16256724

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