CICP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by organism of defense response of other organism involved in symbiotic interact6.22772886
2modulation by symbiont of host immune response (GO:0052553)6.22772886
3positive regulation by symbiont of host defense response (GO:0052509)6.22772886
4modulation by symbiont of host defense response (GO:0052031)6.22772886
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.22772886
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.22772886
7cellular extravasation (GO:0045123)5.69759447
8response to peptidoglycan (GO:0032494)5.20504832
9neutrophil mediated immunity (GO:0002446)5.17014133
10detection of molecule of bacterial origin (GO:0032490)5.16671360
11neutrophil activation involved in immune response (GO:0002283)5.16295010
12positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.87627355
13positive regulation of gamma-delta T cell activation (GO:0046645)4.86515094
14macrophage activation involved in immune response (GO:0002281)4.85041058
15leukocyte migration involved in inflammatory response (GO:0002523)4.82225466
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.79076552
17negative regulation of cell killing (GO:0031342)4.79076552
18regulation of interferon-beta biosynthetic process (GO:0045357)4.72431274
19neutrophil activation (GO:0042119)4.68947775
20regulation of mast cell degranulation (GO:0043304)4.63848271
21regulation of mast cell activation involved in immune response (GO:0033006)4.53949482
22microglial cell activation (GO:0001774)4.53399835
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.48678511
24respiratory burst (GO:0045730)4.30937049
25regulation of B cell receptor signaling pathway (GO:0050855)4.30099274
26myeloid leukocyte mediated immunity (GO:0002444)4.22235888
27response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.21146643
28response to host immune response (GO:0052572)4.21146643
29detection of other organism (GO:0098543)4.20628600
30macrophage activation (GO:0042116)4.20071151
31detection of external biotic stimulus (GO:0098581)4.19323945
32granulocyte activation (GO:0036230)4.14348056
33antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.13274856
34germinal center formation (GO:0002467)4.01160057
35piRNA metabolic process (GO:0034587)3.99216806
36regulation of myeloid leukocyte mediated immunity (GO:0002886)3.99151111
37positive regulation of mast cell activation (GO:0033005)3.97240789
38regulation of mast cell activation (GO:0033003)3.96142581
39negative regulation of interleukin-12 production (GO:0032695)3.91519323
40negative regulation of lymphocyte mediated immunity (GO:0002707)3.89140967
41positive regulation of mast cell activation involved in immune response (GO:0033008)3.85495294
42positive regulation of mast cell degranulation (GO:0043306)3.85495294
43positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.83977307
44positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.81509766
45antigen processing and presentation of endogenous antigen (GO:0019883)3.79679893
46negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.79523021
47response to host (GO:0075136)3.77299233
48response to host defenses (GO:0052200)3.77299233
49response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.77299233
50detection of bacterium (GO:0016045)3.74397050
51negative regulation of phagocytosis (GO:0050765)3.72580278
52myeloid cell activation involved in immune response (GO:0002275)3.68778933
53regulation of leukocyte degranulation (GO:0043300)3.66904284
54regulation of gamma-delta T cell activation (GO:0046643)3.63078989
55leukocyte aggregation (GO:0070486)3.62359565
56antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.62124388
57detection of biotic stimulus (GO:0009595)3.59107176
58response to interleukin-15 (GO:0070672)3.51638501
59negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.49381470
60leukocyte degranulation (GO:0043299)3.47511670
61response to muramyl dipeptide (GO:0032495)3.39548705
62disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.39520497
63killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.39520497
64positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.36621491
65production of molecular mediator involved in inflammatory response (GO:0002532)3.35213319
66positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.35187104
67negative regulation of leukocyte mediated immunity (GO:0002704)3.29872779
68defense response to protozoan (GO:0042832)3.26563726
69negative regulation of erythrocyte differentiation (GO:0045647)3.26280089
70negative regulation of cAMP-mediated signaling (GO:0043951)3.21963332
71regulation of gamma-delta T cell differentiation (GO:0045586)3.20068416
72negative regulation of toll-like receptor signaling pathway (GO:0034122)3.18233559
73negative regulation of interleukin-8 production (GO:0032717)3.16709369
74regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.13004073
75negative regulation of interleukin-6 production (GO:0032715)3.12860360
76regulation of interleukin-6 biosynthetic process (GO:0045408)3.12451084
77negative regulation of T cell mediated immunity (GO:0002710)3.10898955
78regulation of regulated secretory pathway (GO:1903305)3.10821489
79positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.07238025
80regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.05711546
81immunoglobulin mediated immune response (GO:0016064)3.04914715
82DNA methylation involved in gamete generation (GO:0043046)3.02903845
83neutrophil chemotaxis (GO:0030593)3.00029813
84cellular response to interleukin-15 (GO:0071350)2.99155053
85negative regulation of immunoglobulin mediated immune response (GO:0002890)2.96729276
86negative regulation of B cell mediated immunity (GO:0002713)2.96729276
87positive regulation of interferon-alpha production (GO:0032727)2.95854301
88thrombin receptor signaling pathway (GO:0070493)2.95597133
89regulation of T-helper 2 cell differentiation (GO:0045628)2.95446477
90lipopolysaccharide-mediated signaling pathway (GO:0031663)2.94423206
91negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.92076494
92negative regulation of T-helper cell differentiation (GO:0045623)2.92076494
93neutrophil migration (GO:1990266)2.91708270
94positive regulation of toll-like receptor signaling pathway (GO:0034123)2.90663966
95superoxide anion generation (GO:0042554)2.87367234
96response to protozoan (GO:0001562)2.86506944
97myeloid leukocyte activation (GO:0002274)2.86502168
98regulation of interleukin-8 biosynthetic process (GO:0045414)2.85422129
99B cell receptor signaling pathway (GO:0050853)2.85311714
100regulation of toll-like receptor signaling pathway (GO:0034121)2.81510137

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.99113666
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.88216635
3MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.61626377
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.55170052
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.32294667
6VDR_21846776_ChIP-Seq_THP-1_Human3.20018382
7SCL_19346495_ChIP-Seq_HPC-7_Human2.94183750
8VDR_24763502_ChIP-Seq_THP-1_Human2.78722744
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.71005753
10RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.70215112
11SPI1_23127762_ChIP-Seq_K562_Human2.68561072
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.57134502
13SPI1_23547873_ChIP-Seq_NB4_Human2.44130099
14RUNX_20019798_ChIP-Seq_JUKART_Human2.41759582
15E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.35343920
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.30805066
17MYC_22102868_ChIP-Seq_BL_Human2.25953463
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.25133213
19MAF_26560356_Chip-Seq_TH1_Human2.19213902
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.15683614
21RUNX1_22412390_ChIP-Seq_EML_Mouse2.14142504
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.12298932
23UTX_26944678_Chip-Seq_JUKART_Human1.97740856
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.96922498
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.94047818
26MAF_26560356_Chip-Seq_TH2_Human1.91585168
27TCF7_22412390_ChIP-Seq_EML_Mouse1.91074432
28KDM2B_26808549_Chip-Seq_DND41_Human1.88700739
29SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.84792851
30MYB_26560356_Chip-Seq_TH1_Human1.83230994
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.81799178
32GATA1_19941827_ChIP-Seq_MEL_Mouse1.78235775
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.76543076
34MYB_26560356_Chip-Seq_TH2_Human1.75975459
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.74533746
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.74359155
37STAT4_19710469_ChIP-ChIP_TH1__Mouse1.74221383
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.71943602
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.71599815
40LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.69769785
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.68251806
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.67976003
43FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.59747165
44BCL6_27268052_Chip-Seq_Bcells_Human1.57626381
45GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.57344383
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.56454323
47LXR_22292898_ChIP-Seq_THP-1_Human1.56153512
48VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.53834697
49GATA1_22025678_ChIP-Seq_K562_Human1.53498136
50BCOR_27268052_Chip-Seq_Bcells_Human1.51819539
51GATA3_27048872_Chip-Seq_THYMUS_Human1.50416455
52GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.49719445
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.45585061
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.45111622
55Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.42893236
56GATA1_19941826_ChIP-Seq_K562_Human1.42213457
57PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41294974
58CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38479766
59PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38202772
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37851368
61DROSHA_22980978_ChIP-Seq_HELA_Human1.36175189
62GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34531962
63P68_20966046_ChIP-Seq_HELA_Human1.31578326
64PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28318841
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27413079
66SPI1_20517297_ChIP-Seq_HL60_Human1.27246539
67GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26889283
68STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.26696162
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26082428
70PU.1_20513432_ChIP-Seq_Bcells_Mouse1.24167781
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23742951
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23168826
73CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22829042
74RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22699665
75SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.21814467
76SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20335646
77E2F1_20622854_ChIP-Seq_HELA_Human1.18815337
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18300150
79VDR_24787735_ChIP-Seq_THP-1_Human1.15439184
80ESR1_20079471_ChIP-ChIP_T-47D_Human1.13566545
81CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11610433
82RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11530660
83IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10347360
84PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10128899
85CTCF_21964334_ChIP-Seq_BJAB-B_Human1.10036146
86CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08975698
87GATA3_26560356_Chip-Seq_TH2_Human1.08326206
88CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07686099
89RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05511487
90P300_27268052_Chip-Seq_Bcells_Human1.04896200
91SMC4_20622854_ChIP-Seq_HELA_Human1.04498155
92OCT4_19829295_ChIP-Seq_ESCs_Human1.03148494
93RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01561118
94PU_27001747_Chip-Seq_BMDM_Mouse1.01471487
95STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97114317
96NCOR1_26117541_ChIP-Seq_K562_Human0.95166733
97GATA2_19941826_ChIP-Seq_K562_Human0.94939357
98KDM2B_26808549_Chip-Seq_JURKAT_Human0.94659031
99CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94434596
100PHF8_20622854_ChIP-Seq_HELA_Human0.94029484

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.87536430
2MP0003303_peritoneal_inflammation4.12977496
3MP0003436_decreased_susceptibility_to4.01911945
4MP0002419_abnormal_innate_immunity3.02632092
5MP0001835_abnormal_antigen_presentation2.88024196
6MP0009278_abnormal_bone_marrow2.84138945
7MP0008260_abnormal_autophagy2.75036906
8MP0000685_abnormal_immune_system2.66910267
9MP0001800_abnormal_humoral_immune2.50820680
10MP0005025_abnormal_response_to2.45274000
11MP0003191_abnormal_cellular_cholesterol2.38783062
12MP0005248_abnormal_Harderian_gland2.33135768
13MP0002723_abnormal_immune_serum2.30516368
14MP0002420_abnormal_adaptive_immunity2.21937192
15MP0002132_abnormal_respiratory_system2.21258891
16MP0001819_abnormal_immune_cell2.18947779
17MP0005000_abnormal_immune_tolerance2.16123846
18MP0005464_abnormal_platelet_physiology2.14008592
19MP0002452_abnormal_antigen_presenting2.11039594
20MP0003183_abnormal_peptide_metabolism2.10667659
21MP0005387_immune_system_phenotype2.08208474
22MP0001790_abnormal_immune_system2.08208474
23MP0004381_abnormal_hair_follicle2.07145310
24MP0003172_abnormal_lysosome_physiology2.03744361
25MP0005451_abnormal_body_composition2.00852524
26MP0001533_abnormal_skeleton_physiology1.94598485
27MP0009785_altered_susceptibility_to1.86985601
28MP0002405_respiratory_system_inflammati1.81453258
29MP0001986_abnormal_taste_sensitivity1.80563932
30MP0000465_gastrointestinal_hemorrhage1.76912347
31MP0003763_abnormal_thymus_physiology1.76221024
32MP0006082_CNS_inflammation1.74730548
33MP0001545_abnormal_hematopoietic_system1.73357836
34MP0005397_hematopoietic_system_phenotyp1.73357836
35MP0008004_abnormal_stomach_pH1.71827051
36MP0002398_abnormal_bone_marrow1.70722654
37MP0000716_abnormal_immune_system1.66689398
38MP0009764_decreased_sensitivity_to1.65243369
39MP0003300_gastrointestinal_ulcer1.63554800
40MP0005174_abnormal_tail_pigmentation1.60531090
41MP0004130_abnormal_muscle_cell1.53627527
42MP0005671_abnormal_response_to1.52420384
43MP0002148_abnormal_hypersensitivity_rea1.50823326
44MP0002722_abnormal_immune_system1.47699958
45MP0004947_skin_inflammation1.47211366
46MP0005076_abnormal_cell_differentiation1.44659813
47MP0002396_abnormal_hematopoietic_system1.43547936
48MP0001845_abnormal_inflammatory_respons1.43037231
49MP0000689_abnormal_spleen_morphology1.37601591
50MP0000703_abnormal_thymus_morphology1.35894702
51MP0003828_pulmonary_edema1.35288136
52MP0002277_abnormal_respiratory_mucosa1.31977595
53MP0002429_abnormal_blood_cell1.30782431
54MP0010155_abnormal_intestine_physiology1.27416353
55MP0005310_abnormal_salivary_gland1.19668728
56MP0000015_abnormal_ear_pigmentation1.19595469
57MP0008469_abnormal_protein_level1.19225401
58MP0005167_abnormal_blood-brain_barrier1.15953805
59MP0001851_eye_inflammation1.13730621
60MP0003656_abnormal_erythrocyte_physiolo1.10119724
61MP0009333_abnormal_splenocyte_physiolog1.07157968
62MP0001873_stomach_inflammation1.06522228
63MP0005164_abnormal_response_to1.02808217
64MP0009765_abnormal_xenobiotic_induced1.02340162
65MP0005409_darkened_coat_color1.01173912
66MP0005083_abnormal_biliary_tract0.96415202
67MP0003866_abnormal_defecation0.95855189
68MP0004808_abnormal_hematopoietic_stem0.95810162
69MP0004883_abnormal_blood_vessel0.95243488
70MP0002998_abnormal_bone_remodeling0.91827560
71MP0004510_myositis0.87587005
72MP0005390_skeleton_phenotype0.87282016
73MP0005058_abnormal_lysosome_morphology0.87041811
74MP0001663_abnormal_digestive_system0.83298667
75MP0003075_altered_response_to0.80697060
76MP0003045_fibrosis0.79759403
77MP0008961_abnormal_basal_metabolism0.76646653
78MP0006035_abnormal_mitochondrial_morpho0.75944241
79MP0002971_abnormal_brown_adipose0.73585690
80MP0009763_increased_sensitivity_to0.71457432
81MP0003638_abnormal_response/metabolism_0.70641829
82MP0002249_abnormal_larynx_morphology0.69802048
83MP0004484_altered_response_of0.66784098
84MP0000470_abnormal_stomach_morphology0.65811167
85MP0003221_abnormal_cardiomyocyte_apopto0.62811297
86MP0000249_abnormal_blood_vessel0.62590717
87MP0003011_delayed_dark_adaptation0.61832325
88MP0005084_abnormal_gallbladder_morpholo0.59381747
89MP0003878_abnormal_ear_physiology0.58697080
90MP0005377_hearing/vestibular/ear_phenot0.58697080
91MP0010030_abnormal_orbit_morphology0.57273198
92MP0004858_abnormal_nervous_system0.55969563
93MP0008874_decreased_physiological_sensi0.55961405
94MP0005376_homeostasis/metabolism_phenot0.55713261
95MP0005334_abnormal_fat_pad0.55496267
96MP0005166_decreased_susceptibility_to0.54449605
97MP0005075_abnormal_melanosome_morpholog0.54140652
98MP0000858_altered_metastatic_potential0.53606039
99MP0009840_abnormal_foam_cell0.53447704
100MP0008877_abnormal_DNA_methylation0.52944382

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.88516104
2Myositis (HP:0100614)5.46216382
3Orchitis (HP:0100796)5.31537403
4Recurrent bacterial skin infections (HP:0005406)5.19162987
5Recurrent abscess formation (HP:0002722)5.18187104
6Optic neuritis (HP:0100653)4.88334968
7Retrobulbar optic neuritis (HP:0100654)4.88334968
8Abnormality of macrophages (HP:0004311)4.52791590
9Stomatitis (HP:0010280)4.38057760
10Elevated erythrocyte sedimentation rate (HP:0003565)4.28737064
11Recurrent gram-negative bacterial infections (HP:0005420)4.10242648
12Chronic obstructive pulmonary disease (HP:0006510)3.97797030
13Obstructive lung disease (HP:0006536)3.97797030
14Recurrent fungal infections (HP:0002841)3.96428677
15Abnormal delayed hypersensitivity skin test (HP:0002963)3.83283851
16Gastrointestinal infarctions (HP:0005244)3.82280631
17Prolonged bleeding time (HP:0003010)3.80483038
18Recurrent skin infections (HP:0001581)3.69580354
19Spontaneous hematomas (HP:0007420)3.61884782
20Increased IgE level (HP:0003212)3.55241049
21Mediastinal lymphadenopathy (HP:0100721)3.47873434
22Recurrent cutaneous fungal infections (HP:0011370)3.46061527
23Chronic mucocutaneous candidiasis (HP:0002728)3.46061527
24Encephalitis (HP:0002383)3.45057762
25Meningitis (HP:0001287)3.37061453
26Keratoconjunctivitis sicca (HP:0001097)3.33130384
27Peritonitis (HP:0002586)3.26223876
28Annular pancreas (HP:0001734)3.23086833
29Episodic fever (HP:0001954)3.23073604
30Keratoconjunctivitis (HP:0001096)3.19874395
31Chest pain (HP:0100749)3.06366057
32Epistaxis (HP:0000421)3.04267267
33Gingivitis (HP:0000230)3.02568783
34Gingival bleeding (HP:0000225)3.00217667
35Arterial thrombosis (HP:0004420)2.96256495
36Granulocytopenia (HP:0001913)2.93491470
37Urticaria (HP:0001025)2.93450152
38Vasculitis (HP:0002633)2.92225830
39Hypochromic anemia (HP:0001931)2.92188325
40Leukocytosis (HP:0001974)2.83693476
41Abnormal platelet volume (HP:0011876)2.80511995
42Inflammation of the large intestine (HP:0002037)2.79238814
43Cellulitis (HP:0100658)2.71135684
44Hemoptysis (HP:0002105)2.68962877
45Gastrointestinal inflammation (HP:0004386)2.64249935
46Pulmonary embolism (HP:0002204)2.63867610
47Anorexia (HP:0002039)2.63697238
48Abnormality of T cell number (HP:0011839)2.60986641
49T lymphocytopenia (HP:0005403)2.57549680
50Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.56332940
51Eosinophilia (HP:0001880)2.55421242
52Toxemia of pregnancy (HP:0100603)2.53853075
53Hypochromic microcytic anemia (HP:0004840)2.51298604
54Chromosomal breakage induced by crosslinking agents (HP:0003221)2.43122280
55Abnormality of iron homeostasis (HP:0011031)2.38939635
56Petechiae (HP:0000967)2.35320266
57Abnormality of the columella (HP:0009929)2.25570039
58Autoimmune hemolytic anemia (HP:0001890)2.24618191
59Abnormality of the pleura (HP:0002103)2.23889366
60Abnormality of T cells (HP:0002843)2.21625359
61Acute hepatic failure (HP:0006554)2.17347031
62Gangrene (HP:0100758)2.17280170
63Congenital sensorineural hearing impairment (HP:0008527)2.17108996
64Abnormality of T cell physiology (HP:0011840)2.15451431
65Abnormality of the peritoneum (HP:0002585)2.14637377
66Menorrhagia (HP:0000132)2.13864521
67Choroideremia (HP:0001139)2.13418636
68Increased serum ferritin (HP:0003281)2.12007462
69Attenuation of retinal blood vessels (HP:0007843)2.11397603
70Sepsis (HP:0100806)2.10953801
71Osteomyelitis (HP:0002754)2.09004475
72Pulmonary infiltrates (HP:0002113)2.07705026
73Pustule (HP:0200039)2.04581494
74Thrombocytosis (HP:0001894)2.04305112
75Cheilitis (HP:0100825)2.03515782
76Abnormality of the endocardium (HP:0004306)2.02384045
77Recurrent viral infections (HP:0004429)2.02107188
78Abnormality of transition element cation homeostasis (HP:0011030)2.00975263
79Hemorrhage of the eye (HP:0011885)1.99689880
80Metaphyseal cupping (HP:0003021)1.98347410
81Amyloidosis (HP:0011034)1.95971648
82Microcytic anemia (HP:0001935)1.94975844
83Vertigo (HP:0002321)1.94196736
84Intestinal fistula (HP:0100819)1.92506708
85Increased mean platelet volume (HP:0011877)1.92026951
86Abnormality of eosinophils (HP:0001879)1.91616045
87Keratitis (HP:0000491)1.91394949
88Colitis (HP:0002583)1.90614666
89Autoimmune thrombocytopenia (HP:0001973)1.89905079
90Loss of speech (HP:0002371)1.89600516
91Chronic otitis media (HP:0000389)1.89285318
92Acne (HP:0001061)1.88208670
93Spastic paraparesis (HP:0002313)1.87480281
94Easy fatigability (HP:0003388)1.86940664
95Hypertriglyceridemia (HP:0002155)1.86806973
96Hepatosplenomegaly (HP:0001433)1.86516640
97Abnormality of the fingertips (HP:0001211)1.85108243
98Purpura (HP:0000979)1.84021003
99Panhypogammaglobulinemia (HP:0003139)1.83089636
100Abnormality of the heme biosynthetic pathway (HP:0010472)1.79731109

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.98612837
2IRAK43.93247143
3ERN13.37441485
4TNK23.00421645
5MAP2K32.88014188
6MAP4K12.83274272
7EPHB12.78992235
8BLK2.66267530
9CSK2.31337303
10GRK62.25704300
11TYK22.24876666
12MAP3K12.11091700
13ZAP702.02822610
14FES1.98290696
15IRAK11.87122918
16TAOK11.70681149
17MARK31.66340601
18MARK21.64827657
19HCK1.64497400
20IRAK21.52104276
21BTK1.49689590
22PRPF4B1.48578737
23BMPR21.48410745
24MAP3K111.45428011
25SIK11.44020970
26MAP3K31.42958208
27TXK1.42061911
28FGR1.32793999
29JAK31.29812929
30KSR21.29719794
31SYK1.26882410
32SIK21.26278376
33TAOK31.25286896
34PRKD21.22644225
35JAK21.20335263
36MAP3K71.17228740
37PTK2B1.17028741
38IKBKE1.16633632
39MATK1.15618143
40YES11.11032056
41WNK11.03191553
42LYN1.01181969
43PTK60.97866012
44DAPK20.94950870
45TBK10.94852660
46IRAK30.94794079
47TRIB30.93664601
48FRK0.92751752
49SIK30.91823783
50MUSK0.91452912
51PIK3CG0.89684859
52MAP3K140.88044177
53KIT0.87592924
54EPHA30.85517643
55ACVR1B0.84804541
56LCK0.84539227
57PINK10.84437774
58TAOK20.84117113
59NLK0.83898085
60STK380.78272639
61MAP2K40.77353592
62STK110.77036700
63WNK30.75150450
64IKBKB0.69396563
65DYRK1B0.68944963
66MAP3K60.68125616
67BRSK20.67807923
68MAP3K130.65514119
69PDPK10.65347349
70MAP2K60.62117501
71MAP3K20.61731693
72CSF1R0.61691457
73CDC42BPA0.61225874
74RET0.60540410
75PRKG20.58507996
76MAPK120.58472198
77JAK10.57696197
78FGFR30.57664516
79CAMK40.56201731
80STK100.54285471
81ITK0.53202090
82PDK10.52176321
83RPS6KA60.49191666
84CAMKK10.48683664
85TESK20.48318710
86PRKAA20.47076935
87MAP3K50.46119231
88RPS6KA10.43880010
89PRKCZ0.43835484
90RPS6KL10.43042821
91RPS6KC10.43042821
92MAPK70.42436671
93MAPKAPK20.41303076
94SMG10.40489334
95FYN0.40175832
96GRK10.39729091
97RAF10.38311801
98BMX0.37927651
99FER0.37139988
100PRKCQ0.35575422

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.89854476
2Leishmaniasis_Homo sapiens_hsa051402.58902120
3Staphylococcus aureus infection_Homo sapiens_hsa051502.20265059
4B cell receptor signaling pathway_Homo sapiens_hsa046622.10555921
5Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.10428910
6Dorso-ventral axis formation_Homo sapiens_hsa043202.01277604
7Tuberculosis_Homo sapiens_hsa051521.98698250
8Toll-like receptor signaling pathway_Homo sapiens_hsa046201.96013685
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.95621336
10Malaria_Homo sapiens_hsa051441.90330566
11NOD-like receptor signaling pathway_Homo sapiens_hsa046211.89106799
12Acute myeloid leukemia_Homo sapiens_hsa052211.86313046
13Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.84995294
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.72270535
15Non-small cell lung cancer_Homo sapiens_hsa052231.71459950
16Chemokine signaling pathway_Homo sapiens_hsa040621.59365634
17Platelet activation_Homo sapiens_hsa046111.55331522
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.50463454
19Measles_Homo sapiens_hsa051621.45621243
20Legionellosis_Homo sapiens_hsa051341.42349481
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.41489250
22Hematopoietic cell lineage_Homo sapiens_hsa046401.41290714
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.40853964
24African trypanosomiasis_Homo sapiens_hsa051431.40213973
25TNF signaling pathway_Homo sapiens_hsa046681.33350448
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32568224
27Primary immunodeficiency_Homo sapiens_hsa053401.30964169
28T cell receptor signaling pathway_Homo sapiens_hsa046601.30097743
29Hepatitis B_Homo sapiens_hsa051611.29491236
30Toxoplasmosis_Homo sapiens_hsa051451.26469842
31Influenza A_Homo sapiens_hsa051641.22153281
32Regulation of autophagy_Homo sapiens_hsa041401.21043780
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.11740493
34Fatty acid biosynthesis_Homo sapiens_hsa000611.10953499
35Notch signaling pathway_Homo sapiens_hsa043301.10773911
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.07651893
37VEGF signaling pathway_Homo sapiens_hsa043700.99333764
38Glycosaminoglycan degradation_Homo sapiens_hsa005310.99031946
39Pancreatic cancer_Homo sapiens_hsa052120.98737422
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95926621
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.95777974
42Hepatitis C_Homo sapiens_hsa051600.95397701
43Adipocytokine signaling pathway_Homo sapiens_hsa049200.94055756
44Phagosome_Homo sapiens_hsa041450.93772576
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90074194
46Herpes simplex infection_Homo sapiens_hsa051680.89691383
47FoxO signaling pathway_Homo sapiens_hsa040680.88831391
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87813245
49Apoptosis_Homo sapiens_hsa042100.85582361
50Inositol phosphate metabolism_Homo sapiens_hsa005620.83704861
51Renal cell carcinoma_Homo sapiens_hsa052110.80915021
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79589547
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77287574
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76979139
55Graft-versus-host disease_Homo sapiens_hsa053320.76729892
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.76366690
57Glycerophospholipid metabolism_Homo sapiens_hsa005640.75790812
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75482532
59Chronic myeloid leukemia_Homo sapiens_hsa052200.75396406
60ABC transporters_Homo sapiens_hsa020100.73953129
61Olfactory transduction_Homo sapiens_hsa047400.73677862
62Autoimmune thyroid disease_Homo sapiens_hsa053200.72942271
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.72636658
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.70549456
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70376583
66GnRH signaling pathway_Homo sapiens_hsa049120.70192096
67Pertussis_Homo sapiens_hsa051330.68865793
68Endometrial cancer_Homo sapiens_hsa052130.68401076
69Endocytosis_Homo sapiens_hsa041440.67714474
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67466183
71mTOR signaling pathway_Homo sapiens_hsa041500.67215737
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67140971
73Other glycan degradation_Homo sapiens_hsa005110.66001412
74Shigellosis_Homo sapiens_hsa051310.65310875
75Choline metabolism in cancer_Homo sapiens_hsa052310.64823720
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64760828
77Prolactin signaling pathway_Homo sapiens_hsa049170.63362155
78Lysosome_Homo sapiens_hsa041420.62975274
79Arachidonic acid metabolism_Homo sapiens_hsa005900.62278042
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61591303
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60798557
82Type II diabetes mellitus_Homo sapiens_hsa049300.59985491
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59969326
84Rap1 signaling pathway_Homo sapiens_hsa040150.59251589
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58691607
86Allograft rejection_Homo sapiens_hsa053300.58402660
87Salmonella infection_Homo sapiens_hsa051320.58397334
88MAPK signaling pathway_Homo sapiens_hsa040100.57629131
89Insulin resistance_Homo sapiens_hsa049310.56127740
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55680901
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53692747
92Amoebiasis_Homo sapiens_hsa051460.52969340
93Antigen processing and presentation_Homo sapiens_hsa046120.50931722
94Estrogen signaling pathway_Homo sapiens_hsa049150.50767077
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49971001
96Viral carcinogenesis_Homo sapiens_hsa052030.49022606
97Calcium signaling pathway_Homo sapiens_hsa040200.47942274
98Glycerolipid metabolism_Homo sapiens_hsa005610.45683763
99Insulin signaling pathway_Homo sapiens_hsa049100.45636617
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45033163

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