ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA methylation involved in gamete generation (GO:0043046)	9.98115262
2	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	8.90845792
3	lipopolysaccharide biosynthetic process (GO:0009103)	8.80568049
4	protein-chromophore linkage (GO:0018298)	8.23215967
5	piRNA metabolic process (GO:0034587)	8.19860082
6	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	7.90872034
7	lipopolysaccharide metabolic process (GO:0008653)	7.81622334
8	regulation of meiosis I (GO:0060631)	7.78707644
9	negative regulation of glycoprotein biosynthetic process (GO:0010561)	7.27932671
10	sulfate transmembrane transport (GO:1902358)	7.08628197
11	negative regulation of cell cycle G2/M phase transition (GO:1902750)	6.94265436
12	paraxial mesoderm development (GO:0048339)	6.72851089
13	sulfate transport (GO:0008272)	6.70616503
14	regulation of pigment cell differentiation (GO:0050932)	6.58340665
15	regulation of protein glycosylation (GO:0060049)	6.53869450
16	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	6.48085708
17	positive regulation of developmental pigmentation (GO:0048087)	6.47681539
18	tyrosine metabolic process (GO:0006570)	5.55251584
19	SMAD protein complex assembly (GO:0007183)	5.41297178
20	notochord development (GO:0030903)	5.36860174
21	negative regulation of glycoprotein metabolic process (GO:1903019)	5.35493277
22	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	5.32051991
23	L-phenylalanine catabolic process (GO:0006559)	5.32051991
24	heme transport (GO:0015886)	5.12988164
25	centriole replication (GO:0007099)	4.87388667
26	meiotic chromosome segregation (GO:0045132)	4.59950493
27	germinal center formation (GO:0002467)	4.57745399
28	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	4.50927449
29	L-phenylalanine metabolic process (GO:0006558)	4.50927449
30	positive regulation of meiosis (GO:0045836)	4.50192509
31	negative regulation of stem cell proliferation (GO:2000647)	4.48176690
32	regulation of odontogenesis (GO:0042481)	4.33223007
33	nodal signaling pathway (GO:0038092)	4.32246737
34	response to mercury ion (GO:0046689)	4.32229271
35	serotonin receptor signaling pathway (GO:0007210)	4.31781101
36	ribonucleoprotein complex disassembly (GO:0032988)	4.29887498
37	positive regulation of meiotic cell cycle (GO:0051446)	4.28714552
38	gamma-aminobutyric acid signaling pathway (GO:0007214)	4.28157772
39	regulation of transforming growth factor beta2 production (GO:0032909)	4.12667806
40	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.96356029
41	centriole assembly (GO:0098534)	3.95757060
42	regulation of interleukin-5 production (GO:0032674)	3.92877525
43	response to epinephrine (GO:0071871)	3.91958163
44	pantothenate metabolic process (GO:0015939)	3.91224422
45	embryonic process involved in female pregnancy (GO:0060136)	3.86724437
46	cellular response to gamma radiation (GO:0071480)	3.83513536
47	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.83092070
48	glycerol metabolic process (GO:0006071)	3.75102356
49	positive regulation of catecholamine secretion (GO:0033605)	3.74933436
50	tachykinin receptor signaling pathway (GO:0007217)	3.68440536
51	sulfur compound transport (GO:0072348)	3.64722583
52	heart valve formation (GO:0003188)	3.62705396
53	iron coordination entity transport (GO:1901678)	3.57871570
54	rhodopsin mediated signaling pathway (GO:0016056)	3.56149719
55	vitamin transmembrane transport (GO:0035461)	3.55787438
56	negative regulation of neural precursor cell proliferation (GO:2000178)	3.50890500
57	protein retention in ER lumen (GO:0006621)	3.50794400
58	aromatic amino acid family catabolic process (GO:0009074)	3.47530240
59	aspartate family amino acid catabolic process (GO:0009068)	3.46832809
60	DNA damage induced protein phosphorylation (GO:0006975)	3.43940225
61	organelle disassembly (GO:1903008)	3.41296247
62	oogenesis (GO:0048477)	3.40904053
63	inflammatory response to antigenic stimulus (GO:0002437)	3.40755863
64	flavonoid metabolic process (GO:0009812)	3.39445508
65	alditol metabolic process (GO:0019400)	3.29991792
66	DNA methylation (GO:0006306)	3.28590833
67	DNA alkylation (GO:0006305)	3.28590833
68	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.28167070
69	negative regulation of cell-matrix adhesion (GO:0001953)	3.26434609
70	toxin metabolic process (GO:0009404)	3.20866397
71	positive regulation of SMAD protein import into nucleus (GO:0060391)	3.20788611
72	regulation of keratinocyte proliferation (GO:0010837)	3.18012067
73	protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205)	3.15584385
74	aromatic amino acid family metabolic process (GO:0009072)	3.15384956
75	regulation of nephron tubule epithelial cell differentiation (GO:0072182)	3.06629352
76	somite rostral/caudal axis specification (GO:0032525)	3.06227979
77	regulation of developmental pigmentation (GO:0048070)	3.04517954
78	female gamete generation (GO:0007292)	2.92992389
79	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	2.92746707
80	gene silencing by RNA (GO:0031047)	2.92719146
81	uterus development (GO:0060065)	2.90953419
82	regulation of hair follicle development (GO:0051797)	2.89119642
83	spermatid development (GO:0007286)	2.88555409
84	cofactor transport (GO:0051181)	2.82413068
85	polyol biosynthetic process (GO:0046173)	2.79836410
86	sympathetic nervous system development (GO:0048485)	2.78489544
87	organ induction (GO:0001759)	2.76167482
88	regulation of epithelial cell differentiation involved in kidney development (GO:2000696)	2.72411946
89	positive regulation of fatty acid oxidation (GO:0046321)	2.70734145
90	negative regulation of BMP signaling pathway (GO:0030514)	2.70144682
91	membrane lipid biosynthetic process (GO:0046467)	2.70023163
92	sphingolipid biosynthetic process (GO:0030148)	2.69465398
93	meiotic cell cycle (GO:0051321)	2.69297683
94	indolalkylamine metabolic process (GO:0006586)	2.67752111
95	urate metabolic process (GO:0046415)	2.58779786
96	neuroblast proliferation (GO:0007405)	2.58542429
97	positive regulation of histone acetylation (GO:0035066)	2.55151072
98	sphingosine metabolic process (GO:0006670)	16.5422494
99	diol metabolic process (GO:0034311)	15.0551542
100	sphingoid metabolic process (GO:0046519)	13.2995983

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	5.88748181
2	AR_21572438_ChIP-Seq_LNCaP_Human	5.08514505
3	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	3.11838291
4	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	3.07918403
5	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.84782245
6	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.56795211
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.50586382
8	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.22401225
9	P300_19829295_ChIP-Seq_ESCs_Human	2.22387795
10	ER_23166858_ChIP-Seq_MCF-7_Human	2.21974554
11	EZH2_22144423_ChIP-Seq_EOC_Human	2.21906540
12	GBX2_23144817_ChIP-Seq_PC3_Human	2.21889881
13	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.12415846
14	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.12415846
15	ZNF274_21170338_ChIP-Seq_K562_Hela	1.93689203
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.89382351
17	NANOG_19829295_ChIP-Seq_ESCs_Human	1.85991768
18	SOX2_19829295_ChIP-Seq_ESCs_Human	1.85991768
19	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.77609495
20	EGR1_19032775_ChIP-ChIP_M12_Human	1.73980331
21	HOXB7_26014856_ChIP-Seq_BT474_Human	1.71797087
22	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.70560173
23	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.61304538
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.60140877
25	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.59231026
26	OCT4_20526341_ChIP-Seq_ESCs_Human	1.56538583
27	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.55967985
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.55419459
29	STAT1_20625510_ChIP-Seq_HELA_Human	1.54339239
30	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.51005336
31	STAT3_23295773_ChIP-Seq_U87_Human	1.48992123
32	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.48924791
33	TCF4_23295773_ChIP-Seq_U87_Human	1.45327735
34	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	1.43495627
35	AR_25329375_ChIP-Seq_VCAP_Human	1.43212055
36	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.42588005
37	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.41954886
38	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.41480005
39	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.39706787
40	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.38481143
41	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.36626301
42	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.30940248
43	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.28607532
44	VDR_22108803_ChIP-Seq_LS180_Human	1.28384085
45	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.28171688
46	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.27115250
47	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.26770940
48	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.26669336
49	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.26189452
50	STAT3_18555785_ChIP-Seq_MESCs_Mouse	1.25793816
51	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.25784498
52	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.24725627
53	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.21999687
54	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.21158205
55	TP53_18474530_ChIP-ChIP_U2OS_Human	1.20239511
56	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.20056566
57	NCOR_22424771_ChIP-Seq_293T_Human	1.19037760
58	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.18077742
59	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.17913724
60	NANOG_20526341_ChIP-Seq_ESCs_Human	1.14582651
61	STAT1_17558387_ChIP-Seq_HELA_Human	1.11776260
62	SMAD4_21799915_ChIP-Seq_A2780_Human	1.10542716
63	MYC_19829295_ChIP-Seq_ESCs_Human	1.10522074
64	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.10174145
65	RAC3_21632823_ChIP-Seq_H3396_Human	1.10024807
66	AR_19668381_ChIP-Seq_PC3_Human	1.10003506
67	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.09541861
68	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.08928357
69	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08560694
70	SPI1_20517297_ChIP-Seq_HL60_Human	1.08458895
71	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.08361019
72	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.07831287
73	CBP_20019798_ChIP-Seq_JUKART_Human	1.07831287
74	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.07552717
75	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.07106694
76	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.06965538
77	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.06257909
78	TP53_16413492_ChIP-PET_HCT116_Human	1.06046749
79	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.06016309
80	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.05115626
81	TCF4_22108803_ChIP-Seq_LS180_Human	1.04139925
82	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.03853867
83	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.03522576
84	CEBPB_22108803_ChIP-Seq_LS180_Human	1.02741983
85	CDX2_22108803_ChIP-Seq_LS180_Human	1.01408409
86	TP63_23658742_ChIP-Seq_EP156T_Human	1.00758897
87	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.99906825
88	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.99729278
89	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.99540733
90	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.99296515
91	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.99296515
92	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.98960450
93	RUNX2_22187159_ChIP-Seq_PCA_Human	0.98179175
94	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.98136016
95	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.97619520
96	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	0.97553259
97	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97280265
98	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.97115955
99	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.97022545
100	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.96049017

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	9.06402478
2	MP0003136_yellow_coat_color	7.94946439
3	MP0005171_absent_coat_pigmentation	7.79742630
4	MP0002653_abnormal_ependyma_morphology	5.96020885
5	MP0003045_fibrosis	4.67152880
6	MP0003890_abnormal_embryonic-extraembry	4.57220651
7	MP0003646_muscle_fatigue	3.92350381
8	MP0000569_abnormal_digit_pigmentation	3.37143037
9	MP0003879_abnormal_hair_cell	3.17922949
10	MP0004381_abnormal_hair_follicle	3.11505393
11	MP0002138_abnormal_hepatobiliary_system	2.42520983
12	MP0005085_abnormal_gallbladder_physiolo	2.08957046
13	MP0000749_muscle_degeneration	1.99366391
14	MP0005670_abnormal_white_adipose	1.94155139
15	MP0002168_other_aberrant_phenotype	1.91169681
16	MP0005075_abnormal_melanosome_morpholog	1.82764550
17	MP0003195_calcinosis	1.82160301
18	MP0003705_abnormal_hypodermis_morpholog	1.79809398
19	MP0002938_white_spotting	1.65965869
20	MP0004147_increased_porphyrin_level	1.45622049
21	MP0002160_abnormal_reproductive_system	1.44458545
22	MP0002095_abnormal_skin_pigmentation	1.35624382
23	MP0010352_gastrointestinal_tract_polyps	1.34271554
24	MP0005365_abnormal_bile_salt	1.32469309
25	MP0005410_abnormal_fertilization	1.29035201
26	MP0005174_abnormal_tail_pigmentation	1.25716646
27	MP0002075_abnormal_coat/hair_pigmentati	1.22129393
28	MP0005330_cardiomyopathy	1.18174686
29	MP0004233_abnormal_muscle_weight	1.14182220
30	MP0005395_other_phenotype	1.11572876
31	MP0000015_abnormal_ear_pigmentation	0.96010790
32	MP0003137_abnormal_impulse_conducting	0.93983396
33	MP0001186_pigmentation_phenotype	0.88222157
34	MP0008004_abnormal_stomach_pH	0.87230161
35	MP0006054_spinal_hemorrhage	0.87092200
36	MP0001501_abnormal_sleep_pattern	0.86925878
37	MP0002269_muscular_atrophy	0.80097731
38	MP0002102_abnormal_ear_morphology	0.79264239
39	MP0005377_hearing/vestibular/ear_phenot	0.78820437
40	MP0003878_abnormal_ear_physiology	0.78820437
41	MP0003252_abnormal_bile_duct	0.74311663
42	MP0003300_gastrointestinal_ulcer	0.73976302
43	MP0002254_reproductive_system_inflammat	0.70870286
44	MP0000427_abnormal_hair_cycle	0.70551375
45	MP0002735_abnormal_chemical_nociception	0.69842106
46	MP0005076_abnormal_cell_differentiation	0.68769585
47	MP0005389_reproductive_system_phenotype	0.68465559
48	MP0001486_abnormal_startle_reflex	0.64420514
49	MP0009764_decreased_sensitivity_to	0.60058117
50	MP0002277_abnormal_respiratory_mucosa	0.59912898
51	MP0005319_abnormal_enzyme/_coenzyme	0.59455951
52	MP0004043_abnormal_pH_regulation	0.58377715
53	MP0001324_abnormal_eye_pigmentation	0.56596788
54	MP0002396_abnormal_hematopoietic_system	0.56146194
55	MP0001984_abnormal_olfaction	0.55798994
56	MP0008770_decreased_survivor_rate	0.50065716
57	MP0004484_altered_response_of	0.49505819
58	MP0003698_abnormal_male_reproductive	0.49124171
59	MP0000534_abnormal_ureter_morphology	0.48586674
60	MP0002332_abnormal_exercise_endurance	0.45711671
61	MP0001800_abnormal_humoral_immune	0.42811844
62	MP0001929_abnormal_gametogenesis	0.42342143
63	MP0005551_abnormal_eye_electrophysiolog	0.41486901
64	MP0003950_abnormal_plasma_membrane	0.41475647
65	MP0003632_abnormal_nervous_system	0.40934128
66	MP0002971_abnormal_brown_adipose	0.40446855
67	MP0002928_abnormal_bile_duct	0.40220053
68	MP0002272_abnormal_nervous_system	0.39763525
69	MP0008874_decreased_physiological_sensi	0.39689012
70	MP0001661_extended_life_span	0.39602076
71	MP0009115_abnormal_fat_cell	0.39402186
72	MP0001970_abnormal_pain_threshold	0.37870727
73	MP0008569_lethality_at_weaning	0.37847987
74	MP0005387_immune_system_phenotype	0.37771636
75	MP0001790_abnormal_immune_system	0.37771636
76	MP0000470_abnormal_stomach_morphology	0.37714106
77	MP0002210_abnormal_sex_determination	0.35981098
78	MP0000372_irregular_coat_pigmentation	0.35845304
79	MP0003763_abnormal_thymus_physiology	0.35761876
80	MP0009745_abnormal_behavioral_response	0.33771566
81	MP0006036_abnormal_mitochondrial_physio	0.32270019
82	MP0009278_abnormal_bone_marrow	0.32241944
83	MP0003724_increased_susceptibility_to	0.31856953
84	MP0006035_abnormal_mitochondrial_morpho	0.31568331
85	MP0002876_abnormal_thyroid_physiology	0.31362332
86	MP0003959_abnormal_lean_body	0.28353192
87	MP0005620_abnormal_muscle_contractility	0.27491152
88	MP0002751_abnormal_autonomic_nervous	0.26762590
89	MP0000026_abnormal_inner_ear	0.25280368
90	MP0002229_neurodegeneration	0.25121198
91	MP0001145_abnormal_male_reproductive	0.24252612
92	MP0002064_seizures	0.24197924
93	MP0001544_abnormal_cardiovascular_syste	0.23242584
94	MP0005385_cardiovascular_system_phenoty	0.23242584
95	MP0003315_abnormal_perineum_morphology	0.23103022
96	MP0008872_abnormal_physiological_respon	0.23031931
97	MP0002452_abnormal_antigen_presenting	0.22399224
98	MP0000371_diluted_coat_color	0.21547204
99	MP0004130_abnormal_muscle_cell	0.21062929
100	MP0002572_abnormal_emotion/affect_behav	0.20788448

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Focal motor seizures (HP:0011153)	9.23144475
2	Acanthocytosis (HP:0001927)	7.28308592
3	Parakeratosis (HP:0001036)	7.28040822
4	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	7.21604040
5	Aplastic anemia (HP:0001915)	5.96967624
6	Spontaneous hematomas (HP:0007420)	5.50681023
7	Proximal amyotrophy (HP:0007126)	4.66077200
8	Dialeptic seizures (HP:0011146)	4.56110124
9	Colon cancer (HP:0003003)	4.35142674
10	Aplasia/Hypoplasia of the uvula (HP:0010293)	4.35013541
11	Hematochezia (HP:0002573)	4.31910418
12	Rectal prolapse (HP:0002035)	4.22960572
13	Abnormality of aromatic amino acid family metabolism (HP:0004338)	4.14144991
14	Congenital ichthyosiform erythroderma (HP:0007431)	3.93646027
15	Vertebral arch anomaly (HP:0008438)	3.86370549
16	Scapular winging (HP:0003691)	3.76049317
17	Difficulty walking (HP:0002355)	3.70570889
18	Focal seizures (HP:0007359)	3.57757722
19	Progressive inability to walk (HP:0002505)	3.47687480
20	Pancreatic cysts (HP:0001737)	3.43057885
21	Erythroderma (HP:0001019)	3.41843200
22	Ulnar claw (HP:0001178)	3.24099671
23	Esophageal varix (HP:0002040)	3.19654158
24	Conjunctival telangiectasia (HP:0000524)	3.19377804
25	Ulnar bowing (HP:0003031)	3.10747595
26	Broad ribs (HP:0000885)	3.09945260
27	Poikilocytosis (HP:0004447)	3.08264364
28	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.06775790
29	Enlarged kidneys (HP:0000105)	3.05846968
30	Pendular nystagmus (HP:0012043)	3.03533746
31	Bilateral sensorineural hearing impairment (HP:0008619)	3.02302556
32	Potter facies (HP:0002009)	3.01275578
33	Facial shape deformation (HP:0011334)	3.01275578
34	Colitis (HP:0002583)	2.73337336
35	Radial bowing (HP:0002986)	2.71612946
36	Abnormality of the vocal cords (HP:0008777)	2.70733084
37	Petechiae (HP:0000967)	2.63806361
38	Hypoplastic iliac wings (HP:0002866)	2.62069302
39	Gangrene (HP:0100758)	2.60397062
40	Inability to walk (HP:0002540)	2.56380950
41	IgM deficiency (HP:0002850)	2.55296417
42	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.52333172
43	Overlapping toe (HP:0001845)	2.52254632
44	Severe visual impairment (HP:0001141)	2.51869381
45	Abnormality of the shoulder girdle musculature (HP:0001435)	2.50166908
46	Chronic diarrhea (HP:0002028)	2.39318822
47	Cerebellar dysplasia (HP:0007033)	2.36456781
48	Decreased circulating renin level (HP:0003351)	2.34615961
49	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.34028193
50	Portal hypertension (HP:0001409)	2.33095071
51	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.30752433
52	Synostosis of carpal bones (HP:0005048)	2.28087360
53	Autoimmune hemolytic anemia (HP:0001890)	2.23763722
54	Abnormality of the renal cortex (HP:0011035)	2.23458078
55	Recurrent sinusitis (HP:0011108)	2.20373031
56	Opisthotonus (HP:0002179)	2.20018249
57	Abnormality of the hepatic vasculature (HP:0006707)	2.18202544
58	Abnormality of macular pigmentation (HP:0008002)	2.17535936
59	Peripheral hypomyelination (HP:0007182)	2.15425210
60	Tarsal synostosis (HP:0008368)	2.14006302
61	Albinism (HP:0001022)	2.09755605
62	Hypokalemia (HP:0002900)	2.07787777
63	Thickened calvaria (HP:0002684)	2.06082491
64	Clumsiness (HP:0002312)	2.04208094
65	Abnormality of potassium homeostasis (HP:0011042)	2.01498226
66	Amelogenesis imperfecta (HP:0000705)	10.1386551
67	Lack of skin elasticity (HP:0100679)	1.99183510
68	Congenital stationary night blindness (HP:0007642)	1.98965392
69	Abnormality of the fingertips (HP:0001211)	1.98856203
70	Synostosis involving bones of the feet (HP:0009140)	1.96010403
71	Synostosis involving bones of the lower limbs (HP:0009138)	1.96010403
72	Abnormality of the renal medulla (HP:0100957)	1.96006404
73	Hypoalbuminemia (HP:0003073)	1.95969006
74	Abnormal albumin level (HP:0012116)	1.95969006
75	Dehydration (HP:0001944)	1.91877733
76	Chromsome breakage (HP:0040012)	1.89366807
77	Stomach cancer (HP:0012126)	1.88189541
78	Inflammation of the large intestine (HP:0002037)	1.83380382
79	Gastrointestinal stroma tumor (HP:0100723)	1.82986279
80	Type I transferrin isoform profile (HP:0003642)	1.81382104
81	Retinitis pigmentosa (HP:0000510)	1.79212492
82	Type II lissencephaly (HP:0007260)	1.77933880
83	Palmoplantar keratoderma (HP:0000982)	1.76041233
84	Hyperkalemia (HP:0002153)	1.74825638
85	Aortic valve stenosis (HP:0001650)	1.74006842
86	Neoplasm of the small intestine (HP:0100833)	1.73668095
87	Cystic liver disease (HP:0006706)	1.72515426
88	Visceral angiomatosis (HP:0100761)	1.70633684
89	Carpal synostosis (HP:0009702)	1.69264265
90	Purpura (HP:0000979)	1.68772744
91	Bowing of the arm (HP:0006488)	1.68480193
92	Bowed forearm bones (HP:0003956)	1.68480193
93	Photophobia (HP:0000613)	1.67988505
94	Pancytopenia (HP:0001876)	1.66901078
95	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.66107584
96	Absent/shortened dynein arms (HP:0200106)	1.66107584
97	Tubulointerstitial fibrosis (HP:0005576)	1.65582033
98	Gastrointestinal inflammation (HP:0004386)	1.65092974
99	Postural instability (HP:0002172)	1.64011240
100	Nonprogressive disorder (HP:0003680)	1.63192770

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK38L	7.12866151
2	LATS2	6.53876702
3	ZAK	3.09300180
4	STK38	2.84447199
5	PRKD3	2.71059678
6	ACVR1B	2.44910571
7	NLK	2.44676169
8	PINK1	2.20732116
9	MAP2K2	2.08390077
10	STK3	2.07738923
11	FRK	2.07326518
12	MELK	2.00135957
13	LATS1	10.9419883
14	BMPR1B	1.54241331
15	NEK2	1.38180851
16	MAP3K2	1.31562551
17	KSR2	1.12077742
18	PIK3CG	1.08722939
19	TAF1	1.05873516
20	PDPK1	1.04506919
21	PRKAA2	1.00520567
22	IRAK3	0.86193178
23	EIF2AK3	0.83281311
24	TGFBR1	0.74434277
25	CSNK1A1L	0.72722713
26	GRK7	0.70158011
27	MARK3	0.62545218
28	DAPK2	0.60429657
29	PRKD1	0.57991698
30	TNK2	0.54742305
31	MOS	0.53735562
32	TGFBR2	0.49738430
33	ADRBK2	0.47553458
34	GRK5	0.45648310
35	ADRBK1	0.45385683
36	TAOK3	0.42412998
37	STK10	0.40630843
38	MAP2K1	0.37904994
39	STK11	0.37823793
40	DYRK3	0.36956827
41	NEK9	0.35244284
42	TTK	0.32943170
43	MAP3K1	0.31812485
44	PIM1	0.29336522
45	NME1	0.28855921
46	CDK3	0.26062231
47	PLK1	0.24744306
48	TXK	0.22886397
49	TLK1	0.19638721
50	IRAK4	0.19029956
51	WNK4	0.18918531
52	AKT2	0.18836588
53	MUSK	0.17935511
54	EEF2K	0.15421925
55	JAK2	0.14211417
56	CSNK1D	0.13491108
57	MAPK3	0.10483668
58	NUAK1	0.09722014
59	TEC	0.08580078
60	PRKCI	0.08330112
61	CHEK2	0.08054191
62	MAPK1	0.07425857
63	ITK	0.07394466
64	OXSR1	0.07158631
65	ABL1	0.07144677
66	MAP4K1	0.06391143
67	WNK3	0.05484897
68	PRKG2	0.04934046
69	BTK	0.04529536
70	PDK1	0.03994330
71	PTK2B	0.03568595
72	GRK1	0.03089085
73	RPS6KA5	0.02526530
74	RET	0.02133260
75	MAPKAPK3	0.01874890
76	CAMK1D	0.01423506
77	MAP3K8	0.00641801
78	PDGFRB	-0.0833754
79	EIF2AK2	-0.0792245
80	CSNK1A1	-0.0773688
81	INSRR	-0.0750527
82	FER	-0.0724333
83	WNK1	-0.0623125
84	MAPK8	-0.0583502
85	MAPK7	-0.0581500
86	RPS6KB1	-0.0564668
87	ATR	-0.0547792
88	PRKCE	-0.0531681
89	PRKCQ	-0.0501144
90	CDK5	-0.0422603
91	ERBB4	-0.0395857
92	PRKACB	-0.0365513
93	NEK1	-0.0337037
94	MAP3K7	-0.0334994
95	AKT1	-0.0326632
96	PAK1	-0.0326520
97	MAPKAPK5	-0.0133341
98	NEK6	-0.0094981
99	OBSCN	-0.0063471
100	PRKACA	-0.0029120

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	8.42926380
2	Phototransduction_Homo sapiens_hsa04744	4.58965316
3	Sphingolipid metabolism_Homo sapiens_hsa00600	3.83213012
4	Dorso-ventral axis formation_Homo sapiens_hsa04320	3.81754959
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.40309640
6	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.30595432
7	Nicotine addiction_Homo sapiens_hsa05033	2.40727214
8	Phenylalanine metabolism_Homo sapiens_hsa00360	2.15261715
9	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.09208839
10	Taste transduction_Homo sapiens_hsa04742	2.05307454
11	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.04181780
12	Morphine addiction_Homo sapiens_hsa05032	1.80565457
13	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.78105640
14	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.76423365
15	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.35060966
16	One carbon pool by folate_Homo sapiens_hsa00670	1.30790278
17	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.24507476
18	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.22931148
19	Olfactory transduction_Homo sapiens_hsa04740	1.17963812
20	Histidine metabolism_Homo sapiens_hsa00340	1.17373550
21	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.17265258
22	Sphingolipid signaling pathway_Homo sapiens_hsa04071	1.15626130
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.14809824
24	GABAergic synapse_Homo sapiens_hsa04727	1.14779440
25	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.14021125
26	Calcium signaling pathway_Homo sapiens_hsa04020	1.13014432
27	VEGF signaling pathway_Homo sapiens_hsa04370	1.00310058
28	Tryptophan metabolism_Homo sapiens_hsa00380	0.98906666
29	Viral myocarditis_Homo sapiens_hsa05416	0.94489923
30	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.91167339
31	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.90813245
32	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.90295401
33	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.89339144
34	Basal transcription factors_Homo sapiens_hsa03022	0.88028179
35	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.82883900
36	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.81411863
37	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.80204391
38	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.79989676
39	Tyrosine metabolism_Homo sapiens_hsa00350	0.77823389
40	ABC transporters_Homo sapiens_hsa02010	0.76799146
41	Serotonergic synapse_Homo sapiens_hsa04726	0.75797781
42	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.75112152
43	beta-Alanine metabolism_Homo sapiens_hsa00410	0.74023238
44	Gap junction_Homo sapiens_hsa04540	0.70575603
45	Glutamatergic synapse_Homo sapiens_hsa04724	0.70080913
46	Adherens junction_Homo sapiens_hsa04520	0.69063100
47	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.67126570
48	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.65903879
49	Glycerolipid metabolism_Homo sapiens_hsa00561	0.64621276
50	Tuberculosis_Homo sapiens_hsa05152	0.64179947
51	cAMP signaling pathway_Homo sapiens_hsa04024	0.62702514
52	Bile secretion_Homo sapiens_hsa04976	0.57612020
53	Colorectal cancer_Homo sapiens_hsa05210	0.53120698
54	Butanoate metabolism_Homo sapiens_hsa00650	0.51269636
55	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.50434073
56	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.48433076
57	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.48016141
58	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.45970760
59	Pyruvate metabolism_Homo sapiens_hsa00620	0.43053537
60	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.41305623
61	Fatty acid degradation_Homo sapiens_hsa00071	0.41024325
62	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.38740447
63	ECM-receptor interaction_Homo sapiens_hsa04512	0.38378868
64	Thyroid cancer_Homo sapiens_hsa05216	0.37781267
65	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.34449873
66	Melanogenesis_Homo sapiens_hsa04916	0.31626135
67	Linoleic acid metabolism_Homo sapiens_hsa00591	0.31171063
68	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.31078291
69	African trypanosomiasis_Homo sapiens_hsa05143	0.30614317
70	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.29941722
71	Folate biosynthesis_Homo sapiens_hsa00790	0.29825842
72	Basal cell carcinoma_Homo sapiens_hsa05217	0.29301113
73	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.28770958
74	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.28359016
75	Fanconi anemia pathway_Homo sapiens_hsa03460	0.28058190
76	Oocyte meiosis_Homo sapiens_hsa04114	0.26664510
77	Hippo signaling pathway_Homo sapiens_hsa04390	0.26601417
78	Sulfur relay system_Homo sapiens_hsa04122	0.26385779
79	Estrogen signaling pathway_Homo sapiens_hsa04915	0.24401736
80	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.23530956
81	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.23507513
82	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.23504363
83	Pancreatic cancer_Homo sapiens_hsa05212	0.21659720
84	Chemical carcinogenesis_Homo sapiens_hsa05204	0.21369682
85	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.20860697
86	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.20858809
87	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.18814995
88	Type II diabetes mellitus_Homo sapiens_hsa04930	0.18371942
89	Gastric acid secretion_Homo sapiens_hsa04971	0.18000843
90	Salivary secretion_Homo sapiens_hsa04970	0.17595203
91	Cell cycle_Homo sapiens_hsa04110	0.15427813
92	Circadian entrainment_Homo sapiens_hsa04713	0.14712818
93	Arginine and proline metabolism_Homo sapiens_hsa00330	0.14623554
94	Lysine degradation_Homo sapiens_hsa00310	0.14147581
95	Retinol metabolism_Homo sapiens_hsa00830	0.13641981
96	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.12903999
97	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.12279442
98	Homologous recombination_Homo sapiens_hsa03440	0.12131537
99	Glutathione metabolism_Homo sapiens_hsa00480	0.11941224
100	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.11673758

CICP6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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