CIDEA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)9.30055742
2* regulation of sequestering of triglyceride (GO:0010889)9.08801364
3tricarboxylic acid cycle (GO:0006099)8.80076300
4carnitine shuttle (GO:0006853)8.74260423
5regulation of acyl-CoA biosynthetic process (GO:0050812)8.57825217
6fatty acid transmembrane transport (GO:1902001)8.22079390
7regulation of coenzyme metabolic process (GO:0051196)8.15578699
8regulation of cofactor metabolic process (GO:0051193)8.15578699
9regulation of fatty acid oxidation (GO:0046320)7.62844244
10NADH metabolic process (GO:0006734)7.23307635
11biotin metabolic process (GO:0006768)7.20319519
12fatty acid beta-oxidation (GO:0006635)6.70068411
13carnitine transmembrane transport (GO:1902603)6.63535783
14positive regulation of fatty acid oxidation (GO:0046321)6.49668812
15regulation of sulfur metabolic process (GO:0042762)6.45099075
16acyl-CoA biosynthetic process (GO:0071616)6.35729816
17thioester biosynthetic process (GO:0035384)6.35729816
18brown fat cell differentiation (GO:0050873)6.29835514
19amino-acid betaine transport (GO:0015838)6.08203945
20carnitine transport (GO:0015879)6.08203945
21fatty acid homeostasis (GO:0055089)6.05974659
22white fat cell differentiation (GO:0050872)5.98736385
23respiratory electron transport chain (GO:0022904)5.98679397
24diacylglycerol metabolic process (GO:0046339)5.96166009
25triglyceride catabolic process (GO:0019433)5.96009391
26electron transport chain (GO:0022900)5.85398478
27regulation of vascular endothelial growth factor signaling pathway (GO:1900746)5.85044990
28succinate metabolic process (GO:0006105)5.79841927
29fatty acid oxidation (GO:0019395)5.75075469
30fatty acid catabolic process (GO:0009062)5.73107155
31acetyl-CoA metabolic process (GO:0006084)5.72870281
32branched-chain amino acid catabolic process (GO:0009083)5.68468028
33lipid oxidation (GO:0034440)5.65017237
34mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.48467971
35fatty-acyl-CoA biosynthetic process (GO:0046949)5.45780941
36neutral lipid catabolic process (GO:0046461)5.39240126
37acylglycerol catabolic process (GO:0046464)5.39240126
38positive regulation of fatty acid beta-oxidation (GO:0032000)5.33669317
39oxidative phosphorylation (GO:0006119)5.28829707
40regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)5.27741978
41coenzyme A biosynthetic process (GO:0015937)5.20712756
42CDP-diacylglycerol biosynthetic process (GO:0016024)5.10341056
43branched-chain amino acid metabolic process (GO:0009081)5.08547298
44transcytosis (GO:0045056)5.00077571
45triglyceride biosynthetic process (GO:0019432)4.93634224
46valine metabolic process (GO:0006573)4.93354016
47long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.86507480
48intracellular lipid transport (GO:0032365)4.86291039
49CDP-diacylglycerol metabolic process (GO:0046341)4.85887430
50fatty-acyl-CoA metabolic process (GO:0035337)4.79745899
51negative regulation of fatty acid biosynthetic process (GO:0045717)4.79344228
52plasma lipoprotein particle clearance (GO:0034381)4.74701809
53neutral lipid biosynthetic process (GO:0046460)4.72242726
54acylglycerol biosynthetic process (GO:0046463)4.72242726
55regulation of cAMP-dependent protein kinase activity (GO:2000479)4.66593129
56regulation of glycogen (starch) synthase activity (GO:2000465)4.62588678
57short-chain fatty acid metabolic process (GO:0046459)4.61762788
58ethanol oxidation (GO:0006069)4.60678437
59lipid particle organization (GO:0034389)4.59707473
60tricarboxylic acid metabolic process (GO:0072350)4.55792921
61positive regulation of glomerulus development (GO:0090193)4.50297769
62regulation of fatty acid beta-oxidation (GO:0031998)4.44099234
63regulation of triglyceride catabolic process (GO:0010896)4.43785200
64regulation of cholesterol storage (GO:0010885)4.41503509
65quaternary ammonium group transport (GO:0015697)4.40194975
66cardiolipin metabolic process (GO:0032048)4.39261530
67monocarboxylic acid catabolic process (GO:0072329)4.38945658
68protein heterotrimerization (GO:0070208)4.38460206
69thioester metabolic process (GO:0035383)4.37275029
70acyl-CoA metabolic process (GO:0006637)4.37275029
71coenzyme A metabolic process (GO:0015936)4.30582773
72regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)4.30444352
73cellular response to epinephrine stimulus (GO:0071872)4.27807365
74low-density lipoprotein particle clearance (GO:0034383)4.25650119
75polyol transport (GO:0015791)4.25370895
76negative regulation of fatty acid metabolic process (GO:0045922)4.23499701
77regulation of fatty acid metabolic process (GO:0019217)4.19341785
78negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)4.19286853
79long-chain fatty acid transport (GO:0015909)4.17535095
80lysine catabolic process (GO:0006554)4.17138009
81lysine metabolic process (GO:0006553)4.17138009
82long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.14526587
83positive regulation of cholesterol efflux (GO:0010875)4.12872643
84response to dietary excess (GO:0002021)4.12371990
85negative regulation of granulocyte differentiation (GO:0030853)4.10798062
86glycerolipid catabolic process (GO:0046503)4.09232720
87alpha-linolenic acid metabolic process (GO:0036109)4.09068996
88retinol metabolic process (GO:0042572)4.06547764
89primary alcohol metabolic process (GO:0034308)4.02915842
90mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.01529493
91regulation of macrophage derived foam cell differentiation (GO:0010743)4.01488057
92phospholipid homeostasis (GO:0055091)3.99268602
93phosphatidic acid metabolic process (GO:0046473)3.97799780
94phosphatidic acid biosynthetic process (GO:0006654)3.97799780
95pantothenate metabolic process (GO:0015939)3.91475832
96positive regulation of p38MAPK cascade (GO:1900745)3.83888757
97* lipid storage (GO:0019915)3.83249287
98positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.76087204
99negative regulation of macrophage differentiation (GO:0045650)3.73201774
100ethanol metabolic process (GO:0006067)3.71981363
101proline transport (GO:0015824)3.70462838
102positive regulation of sterol transport (GO:0032373)3.68878765
103positive regulation of cholesterol transport (GO:0032376)3.68878765
104L-serine transport (GO:0015825)3.65708523
105positive regulation of lipid catabolic process (GO:0050996)3.64870563
106fatty acid transport (GO:0015908)3.62024103
107positive regulation of lipoprotein lipase activity (GO:0051006)3.61089151
108positive regulation of triglyceride lipase activity (GO:0061365)3.61089151
109glycine transport (GO:0015816)3.59581146
110triglyceride metabolic process (GO:0006641)3.59087912
111carnitine metabolic process (GO:0009437)3.58774973
112response to epinephrine (GO:0071871)3.55525987
113negative regulation of protein autophosphorylation (GO:0031953)3.53053358
114cellular response to lithium ion (GO:0071285)3.52447944
115cellular lipid catabolic process (GO:0044242)3.51714964
116inner mitochondrial membrane organization (GO:0007007)3.50661879
117oligosaccharide biosynthetic process (GO:0009312)3.50408333
118glycerol metabolic process (GO:0006071)3.50105012
119ATP synthesis coupled proton transport (GO:0015986)3.47397655
120energy coupled proton transport, down electrochemical gradient (GO:0015985)3.47397655
121regulation of triglyceride biosynthetic process (GO:0010866)3.44114446
122alanine transport (GO:0032328)3.39758961
123negative regulation of metanephros development (GO:0072217)3.39497283
124quinone biosynthetic process (GO:1901663)3.39272636
125ubiquinone biosynthetic process (GO:0006744)3.39272636
126positive regulation of fatty acid metabolic process (GO:0045923)3.38111723
127acylglycerol metabolic process (GO:0006639)3.37409532
128linoleic acid metabolic process (GO:0043651)3.35232447
129neutral lipid metabolic process (GO:0006638)3.33561192
130negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.33553426
131fatty acid elongation (GO:0030497)3.32796625
132aerobic respiration (GO:0009060)3.31876575
133* positive regulation of lipid storage (GO:0010884)3.31553092
134negative regulation of lipid storage (GO:0010888)3.31390692
135oxaloacetate metabolic process (GO:0006107)3.30117479
136negative regulation of smooth muscle cell migration (GO:0014912)3.29966688
137positive regulation of triglyceride metabolic process (GO:0090208)3.29620724
138retina vasculature morphogenesis in camera-type eye (GO:0061299)3.28838834
139pentose-phosphate shunt (GO:0006098)3.28262235
140negative regulation of phagocytosis (GO:0050765)3.26430066
141ovulation from ovarian follicle (GO:0001542)3.26257801
142regulation of fatty acid biosynthetic process (GO:0042304)3.25864884
143acylglycerol homeostasis (GO:0055090)3.25397452
144triglyceride homeostasis (GO:0070328)3.25397452
145ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.24390427
146nucleoside bisphosphate biosynthetic process (GO:0033866)3.24390427
147purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.24390427
148negative regulation of gluconeogenesis (GO:0045721)3.21200579
149cGMP-mediated signaling (GO:0019934)3.20515461
150regulation of receptor binding (GO:1900120)3.12439016
151protein localization to cell surface (GO:0034394)3.12410026
152hair cycle (GO:0042633)3.11850554
153molting cycle (GO:0042303)3.11850554
154positive regulation of glucose import (GO:0046326)3.11026451
155serine transport (GO:0032329)3.09977854
156regulation of vasculogenesis (GO:2001212)3.09705827
157negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.08685634
158alditol metabolic process (GO:0019400)3.07194340
159positive regulation of glycolytic process (GO:0045821)3.05419562
160barbed-end actin filament capping (GO:0051016)3.04580514

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse7.93463586
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.51864603
3* ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.80361941
4CLOCK_20551151_ChIP-Seq_293T_Human3.56232447
5STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse3.42022812
6RXR_22158963_ChIP-Seq_LIVER_Mouse3.23050305
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.95110931
8ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.83537758
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.57437315
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.37147377
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.34151473
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.30119540
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.18378504
14PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.18251886
15FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.09055097
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse15.0861033
17PPAR_26484153_Chip-Seq_NCI-H1993_Human1.98303223
18ZNF263_19887448_ChIP-Seq_K562_Human1.84344448
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.73904921
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68106855
21PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.66967566
22PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.56928426
23TP63_17297297_ChIP-ChIP_HaCaT_Human1.53009766
24RXR_22108803_ChIP-Seq_LS180_Human1.52825812
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49050707
26ESR1_20079471_ChIP-ChIP_T-47D_Human1.41761045
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.33736412
28CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.33454113
29NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.31735968
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.28370025
31* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.27031276
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26981319
33EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26086149
34EP300_21415370_ChIP-Seq_HL-1_Mouse1.25680684
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25334335
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25044687
37TBX20_22328084_ChIP-Seq_HEART_Mouse1.23183197
38TBX20_22080862_ChIP-Seq_HEART_Mouse1.23183197
39RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.15771454
40EZH2_18974828_ChIP-Seq_MESCs_Mouse1.15575032
41RNF2_18974828_ChIP-Seq_MESCs_Mouse1.15575032
42* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15506445
43SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.14934423
44LXR_22292898_ChIP-Seq_THP-1_Human1.11709295
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.10769535
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08868328
47BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.08266079
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06705783
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.05087780
50CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03383663
51RAD21_21589869_ChIP-Seq_MESCs_Mouse1.02268173
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02150217
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01595752
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.01161787
55TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.99958838
56* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99786819
57SA1_22415368_ChIP-Seq_MEFs_Mouse0.99238202
58KDM2B_26808549_Chip-Seq_K562_Human0.98622430
59EGR1_19032775_ChIP-ChIP_M12_Human0.98199611
60SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98028871
61SMC1_22415368_ChIP-Seq_MEFs_Mouse0.97572411
62* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.94730902
63DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93735613
64FOXO3_23340844_ChIP-Seq_DLD1_Human0.93287409
65SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.93100749
66TRIM28_21343339_ChIP-Seq_HEK293_Human0.92546474
67CTCF_27219007_Chip-Seq_Bcells_Human0.92112799
68NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91656545
69ESR1_21235772_ChIP-Seq_MCF-7_Human0.90695775
70SMC4_20622854_ChIP-Seq_HELA_Human0.90171415
71SMC3_22415368_ChIP-Seq_MEFs_Mouse0.89396988
72BCAT_22108803_ChIP-Seq_LS180_Human0.88781203
73SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.88710239
74JARID2_20075857_ChIP-Seq_MESCs_Mouse0.86685962
75EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.86423408
76WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85662444
77CBP_21632823_ChIP-Seq_H3396_Human0.85615466
78CJUN_26792858_Chip-Seq_BT549_Human0.85064813
79ATF3_27146783_Chip-Seq_COLON_Human0.85060732
80NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.84703271
81NR3C1_23031785_ChIP-Seq_PC12_Mouse0.83310708
82NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.83263535
83CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.83187328
84ERG_21242973_ChIP-ChIP_JURKAT_Human0.81244485
85GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.80566547
86* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.79785179
87* CBP_20019798_ChIP-Seq_JUKART_Human0.79785179
88PIAS1_25552417_ChIP-Seq_VCAP_Human0.78648907
89ERG_20517297_ChIP-Seq_VCAP_Human0.78081906
90GATA3_24758297_ChIP-Seq_MCF-7_Human0.77280116
91NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.77272175
92UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.76713281
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76565004
94CTNNB1_20460455_ChIP-Seq_HCT116_Human0.76534426
95* TP63_22573176_ChIP-Seq_HFKS_Human0.75521925
96TET1_21490601_ChIP-Seq_MESCs_Mouse0.74391869
97EZH2_22144423_ChIP-Seq_EOC_Human0.73362926
98P68_20966046_ChIP-Seq_HELA_Human0.73281022
99AUTS2_25519132_ChIP-Seq_293T-REX_Human0.72973242
100SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.72581615
101PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.72566651
102RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72106188
103SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.70785786
104STAT3_1855785_ChIP-Seq_MESCs_Mouse0.70059309
105EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.70010050
106TP53_20018659_ChIP-ChIP_R1E_Mouse0.68371990
107* KLF4_19829295_ChIP-Seq_ESCs_Human0.68075763
108STAT1_20625510_ChIP-Seq_HELA_Human0.67660134
109AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66979541
110WT1_19549856_ChIP-ChIP_CCG9911_Human0.65495500
111KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.65473511
112TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.64965803
113ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.64686854
114FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.64653700
115SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.63813234
116RUNX1_27514584_Chip-Seq_MCF-7_Human0.63473733
117FOXA1_25552417_ChIP-Seq_VCAP_Human0.63341498
118* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.61704758
119ER_23166858_ChIP-Seq_MCF-7_Human0.61573502
120SOX2_27498859_Chip-Seq_STOMACH_Mouse0.61279270
121SOX9_24532713_ChIP-Seq_HFSC_Mouse0.59858524
122RACK7_27058665_Chip-Seq_MCF-7_Human0.58993140
123HIF1A_21447827_ChIP-Seq_MCF-7_Human0.58651918
124SOX2_20726797_ChIP-Seq_SW620_Human0.57279640
125GATA1_22025678_ChIP-Seq_K562_Human0.56821936
126NRF2_20460467_ChIP-Seq_MEFs_Mouse0.56709808
127NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.56709808
128CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.56134672
129* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.55661648
130PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.55165039
131GATA4_25053715_ChIP-Seq_YYC3_Human0.54408203
132TCF4_22108803_ChIP-Seq_LS180_Human0.53317580
133EOMES_21245162_ChIP-Seq_HESCs_Human0.52745350
134Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.52193836
135FOXA2_19822575_ChIP-Seq_HepG2_Human0.51217446
136EGR1_23403033_ChIP-Seq_LIVER_Mouse0.50811198
137* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.50405507
138GATA2_21666600_ChIP-Seq_HMVEC_Human0.50191185
139AR_25329375_ChIP-Seq_VCAP_Human0.49379733
140SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.49195338
141CEBPB_22108803_ChIP-Seq_LS180_Human0.49092509
142HOXB7_26014856_ChIP-Seq_BT474_Human0.49025468
143TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.48536780
144TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.48333798
145CREB1_15753290_ChIP-ChIP_HEK293T_Human0.48076048
146GATA4_21415370_ChIP-Seq_HL-1_Mouse0.47848467
147PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.46656359
148ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.45619595
149GATA2_19941826_ChIP-Seq_K562_Human0.44827269

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose6.91789970
2MP0004130_abnormal_muscle_cell5.86268040
3MP0005666_abnormal_adipose_tissue5.45041453
4MP0003646_muscle_fatigue5.36618223
5MP0004185_abnormal_adipocyte_glucose5.20921104
6MP0001881_abnormal_mammary_gland4.20261864
7* MP0002971_abnormal_brown_adipose3.76721229
8MP0005375_adipose_tissue_phenotype3.57005030
9MP0006036_abnormal_mitochondrial_physio3.48141149
10MP0000013_abnormal_adipose_tissue2.68249244
11* MP0005535_abnormal_body_temperature2.56416318
12MP0000003_abnormal_adipose_tissue2.30966604
13* MP0002118_abnormal_lipid_homeostasis2.11720765
14MP0002837_dystrophic_cardiac_calcinosis2.11089184
15MP0002332_abnormal_exercise_endurance2.10604684
16MP0005330_cardiomyopathy2.08707082
17MP0003195_calcinosis2.08417261
18MP0005332_abnormal_amino_acid1.96456767
19MP0010329_abnormal_lipoprotein_level1.95341894
20* MP0002970_abnormal_white_adipose1.89423793
21MP0009115_abnormal_fat_cell1.86932313
22MP0005334_abnormal_fat_pad1.86698529
23MP0008775_abnormal_heart_ventricle1.75868399
24MP0006035_abnormal_mitochondrial_morpho1.74488558
25MP0004043_abnormal_pH_regulation1.72643683
26MP0005584_abnormal_enzyme/coenzyme_acti1.68652445
27MP0008961_abnormal_basal_metabolism1.63923777
28MP0002876_abnormal_thyroid_physiology1.62787894
29MP0003221_abnormal_cardiomyocyte_apopto1.58085114
30* MP0002078_abnormal_glucose_homeostasis1.56840972
31MP0003011_delayed_dark_adaptation1.53035983
32MP0006138_congestive_heart_failure1.46130236
33MP0003868_abnormal_feces_composition1.46019652
34MP0005448_abnormal_energy_balance1.44698599
35MP0000609_abnormal_liver_physiology1.40398602
36MP0004087_abnormal_muscle_fiber1.34380635
37MP0009379_abnormal_foot_pigmentation1.33540629
38MP0010234_abnormal_vibrissa_follicle1.29687954
39MP0003724_increased_susceptibility_to1.29669117
40MP0005647_abnormal_sex_gland1.28214391
41* MP0005452_abnormal_adipose_tissue1.26223519
42MP0005085_abnormal_gallbladder_physiolo1.25933119
43MP0001544_abnormal_cardiovascular_syste1.22207604
44MP0005385_cardiovascular_system_phenoty1.22207604
45MP0002972_abnormal_cardiac_muscle1.21131771
46MP0004215_abnormal_myocardial_fiber1.19791586
47MP0001661_extended_life_span1.14820047
48MP0004484_altered_response_of1.13666610
49MP0005620_abnormal_muscle_contractility1.12995872
50MP0005167_abnormal_blood-brain_barrier1.12038603
51MP0005503_abnormal_tendon_morphology1.11548992
52MP0005365_abnormal_bile_salt1.09142337
53MP0004233_abnormal_muscle_weight1.08904059
54MP0003959_abnormal_lean_body1.07753129
55MP0002796_impaired_skin_barrier1.04577342
56MP0008438_abnormal_cutaneous_collagen1.04206206
57MP0004019_abnormal_vitamin_homeostasis1.03211629
58MP0001879_abnormal_lymphatic_vessel1.02869905
59MP0010630_abnormal_cardiac_muscle1.01003550
60MP0009780_abnormal_chondrocyte_physiolo1.00444468
61MP0004036_abnormal_muscle_relaxation0.99904610
62MP0003186_abnormal_redox_activity0.98861206
63MP0000627_abnormal_mammary_gland0.98688038
64MP0003690_abnormal_glial_cell0.97676071
65MP0000759_abnormal_skeletal_muscle0.95855047
66MP0004381_abnormal_hair_follicle0.94242348
67MP0001727_abnormal_embryo_implantation0.94052487
68MP0005319_abnormal_enzyme/_coenzyme0.92712701
69MP0005595_abnormal_vascular_smooth0.92548409
70MP0005501_abnormal_skin_physiology0.91288995
71MP0002295_abnormal_pulmonary_circulatio0.88239514
72MP0004782_abnormal_surfactant_physiolog0.86984661
73MP0004084_abnormal_cardiac_muscle0.86859764
74MP0002638_abnormal_pupillary_reflex0.86528274
75MP0002060_abnormal_skin_morphology0.86258307
76MP0000343_altered_response_to0.85377598
77MP0004147_increased_porphyrin_level0.85274614
78MP0003279_aneurysm0.84328519
79MP0003705_abnormal_hypodermis_morpholog0.83880636
80MP0003948_abnormal_gas_homeostasis0.82651369
81MP0002139_abnormal_hepatobiliary_system0.81516062
82MP0010368_abnormal_lymphatic_system0.79802703
83MP0002108_abnormal_muscle_morphology0.79040272
84MP0000249_abnormal_blood_vessel0.78557702
85MP0000749_muscle_degeneration0.78456798
86MP0000751_myopathy0.77923370
87MP0005266_abnormal_metabolism0.76543913
88MP0003953_abnormal_hormone_level0.75968407
89MP0002254_reproductive_system_inflammat0.75435843
90MP0005275_abnormal_skin_tensile0.75298439
91MP0005164_abnormal_response_to0.75162065
92MP0003453_abnormal_keratinocyte_physiol0.74522273
93MP0009643_abnormal_urine_homeostasis0.72671645
94MP0005360_urolithiasis0.70908379
95MP0005379_endocrine/exocrine_gland_phen0.70037524
96MP0000750_abnormal_muscle_regeneration0.69532804
97MP0004272_abnormal_basement_membrane0.68508654
98MP0005386_behavior/neurological_phenoty0.68397729
99MP0004924_abnormal_behavior0.68397729
100MP0000647_abnormal_sebaceous_gland0.66121142
101MP0000230_abnormal_systemic_arterial0.65698908
102MP0002106_abnormal_muscle_physiology0.65386411
103MP0000858_altered_metastatic_potential0.64415968
104MP0005388_respiratory_system_phenotype0.64304195
105MP0002133_abnormal_respiratory_system0.64304195
106MP0005645_abnormal_hypothalamus_physiol0.64170032
107MP0008872_abnormal_physiological_respon0.62069436
108MP0004858_abnormal_nervous_system0.61996074
109MP0000747_muscle_weakness0.61959954
110MP0003950_abnormal_plasma_membrane0.61268058
111MP0005409_darkened_coat_color0.60915855
112MP0002933_joint_inflammation0.59485160
113MP0001177_atelectasis0.58278248
114MP0002098_abnormal_vibrissa_morphology0.58042729
115MP0001216_abnormal_epidermal_layer0.57717651
116MP0003566_abnormal_cell_adhesion0.57698330
117MP0001958_emphysema0.57341051
118MP0002168_other_aberrant_phenotype0.57087472
119MP0001764_abnormal_homeostasis0.53725841
120MP0001501_abnormal_sleep_pattern0.52423098
121MP0002269_muscular_atrophy0.51545082
122MP0000767_abnormal_smooth_muscle0.51046532
123MP0003137_abnormal_impulse_conducting0.50574700
124MP0004085_abnormal_heartbeat0.50573723
125MP0003191_abnormal_cellular_cholesterol0.49977019
126MP0009672_abnormal_birth_weight0.46798034
127MP0003879_abnormal_hair_cell0.45802967
128MP0003828_pulmonary_edema0.45137258
129MP0005083_abnormal_biliary_tract0.44954174
130MP0005376_homeostasis/metabolism_phenot0.43915804
131* MP0009642_abnormal_blood_homeostasis0.42857979
132MP0005369_muscle_phenotype0.41160137
133MP0003136_yellow_coat_color0.40548611
134MP0001664_abnormal_digestion0.40493431
135MP0002909_abnormal_adrenal_gland0.39834519
136MP0001756_abnormal_urination0.39432784

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)6.49617998
2Hyperglycinuria (HP:0003108)5.81146410
3Dicarboxylic aciduria (HP:0003215)5.76948978
4Abnormality of dicarboxylic acid metabolism (HP:0010995)5.76948978
5Myoglobinuria (HP:0002913)5.69815407
6Abnormality of fatty-acid metabolism (HP:0004359)5.69807231
7Hepatic necrosis (HP:0002605)5.52272290
8Rhabdomyolysis (HP:0003201)5.20137089
9Generalized aminoaciduria (HP:0002909)5.15791094
10Abnormality of glycolysis (HP:0004366)4.80192523
11Increased serum pyruvate (HP:0003542)4.80192523
12Abnormality of glycine metabolism (HP:0010895)4.67336629
13Abnormality of serine family amino acid metabolism (HP:0010894)4.67336629
14Abnormal mitochondria in muscle tissue (HP:0008316)4.66039006
15Acute necrotizing encephalopathy (HP:0006965)4.64086662
16Nausea (HP:0002018)4.54945432
17Acute encephalopathy (HP:0006846)4.51926237
18Insulin resistance (HP:0000855)4.34998660
19Renal cortical cysts (HP:0000803)4.30000697
20Increased muscle lipid content (HP:0009058)4.25946383
21Myocardial infarction (HP:0001658)4.24298118
22Cerebral edema (HP:0002181)4.20558914
23Hyperlipoproteinemia (HP:0010980)4.20018471
24Increased variability in muscle fiber diameter (HP:0003557)4.17745336
25Abnormality of alanine metabolism (HP:0010916)4.14906393
26Hyperalaninemia (HP:0003348)4.14906393
27Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.14906393
28Methylmalonic aciduria (HP:0012120)4.08189894
29Ketoacidosis (HP:0001993)4.04451721
30Conjunctival hamartoma (HP:0100780)4.00822032
31Progressive macrocephaly (HP:0004481)3.99992184
32Oligomenorrhea (HP:0000876)3.89118453
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.86291670
34Protrusio acetabuli (HP:0003179)3.82636844
35Hepatocellular necrosis (HP:0001404)3.77359054
36Skin nodule (HP:0200036)3.66216798
37Hyperammonemia (HP:0001987)3.64978120
38Proximal tubulopathy (HP:0000114)3.64152430
39Ketosis (HP:0001946)3.63890133
40Lactic acidosis (HP:0003128)3.62419658
41Hyperglycinemia (HP:0002154)3.61437490
42Axonal loss (HP:0003447)3.50912704
43Hydroxyprolinuria (HP:0003080)3.49736475
44Abnormality of proline metabolism (HP:0010907)3.49736475
45Complement deficiency (HP:0004431)3.49277319
46Increased CSF lactate (HP:0002490)3.49124393
47Abnormality of skeletal muscle fiber size (HP:0012084)3.41857670
48Lethargy (HP:0001254)3.41162923
49Growth hormone excess (HP:0000845)3.34642094
50Mitochondrial inheritance (HP:0001427)3.34107856
51Pheochromocytoma (HP:0002666)3.23702894
52Abnormality of serum amino acid levels (HP:0003112)3.21310253
53Subcapsular cataract (HP:0000523)3.17033390
54Respiratory failure (HP:0002878)3.14422388
55Methylmalonic acidemia (HP:0002912)3.10207332
56Long foot (HP:0001833)3.07967575
57Bone cyst (HP:0012062)3.06753963
58Hemorrhage of the eye (HP:0011885)3.06230460
59Abnormality of complement system (HP:0005339)2.99927929
60Increased IgE level (HP:0003212)2.99535102
61Decreased activity of mitochondrial respiratory chain (HP:0008972)2.94441996
62Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.94441996
63Hypotrichosis (HP:0001006)2.90527395
64Vertebral compression fractures (HP:0002953)2.90117775
65Hypercholesterolemia (HP:0003124)2.89936284
66Neonatal death (HP:0003811)2.88683744
67Esophageal neoplasm (HP:0100751)2.86080203
68Neoplasm of head and neck (HP:0012288)2.86080203
69Pigmentary retinal degeneration (HP:0001146)2.84126854
70Abnormal eating behavior (HP:0100738)2.81633727
71Neuroendocrine neoplasm (HP:0100634)2.81335034
72Palpitations (HP:0001962)2.78889615
73Back pain (HP:0003418)2.78883754
74Muscle fiber splitting (HP:0003555)2.75239737
75Exercise-induced myalgia (HP:0003738)2.74909859
76Hypercortisolism (HP:0001578)2.74616131
77Vomiting (HP:0002013)2.73028429
78Spinal rigidity (HP:0003306)2.71268677
79Hypertriglyceridemia (HP:0002155)2.69823165
80Nephritis (HP:0000123)2.68471066
81Athetosis (HP:0002305)2.66455787
82Woolly hair (HP:0002224)2.66185907
83Metabolic acidosis (HP:0001942)2.65614746
84Increased intramyocellular lipid droplets (HP:0012240)2.62164117
85Acanthosis nigricans (HP:0000956)2.61398024
86Polyphagia (HP:0002591)2.61367797
87Insulin-resistant diabetes mellitus (HP:0000831)2.57583632
88Hamartoma of the eye (HP:0010568)2.57543620
89Polar cataract (HP:0010696)2.55321218
90Exercise intolerance (HP:0003546)2.53019094
91Multiple enchondromatosis (HP:0005701)2.51214056
92Aortic aneurysm (HP:0004942)2.47083811
93Lipid accumulation in hepatocytes (HP:0006561)2.44235636
94Pili torti (HP:0003777)2.43441423
95Colitis (HP:0002583)2.42917313
96Onycholysis (HP:0001806)2.41622034
97Lymphangioma (HP:0100764)2.39601169
98Prominent supraorbital ridges (HP:0000336)2.38159215
99Muscle stiffness (HP:0003552)2.37445047
100Abnormality of the periventricular white matter (HP:0002518)2.35834695
101Abnormality of the renal cortex (HP:0011035)2.33265828
102Amyloidosis (HP:0011034)2.32744584
103Difficulty running (HP:0009046)2.32086848
104Systemic lupus erythematosus (HP:0002725)2.30955985
105Polycythemia (HP:0001901)2.30186546
106Lipoatrophy (HP:0100578)2.29986443
107Ileus (HP:0002595)2.29732884
108Ectopia lentis (HP:0001083)2.28431232
109Accelerated skeletal maturation (HP:0005616)2.25941630
110Neoplasm of the adrenal gland (HP:0100631)2.25777053
111Leukodystrophy (HP:0002415)2.25681572
112Optic disc pallor (HP:0000543)2.25632983
113Ragged-red muscle fibers (HP:0003200)2.21463914
114Epidermoid cyst (HP:0200040)2.20621296
115Increased serum lactate (HP:0002151)2.18904734
116Abnormal cartilage morphology (HP:0002763)2.18791912
117Limb hypertonia (HP:0002509)2.17758545
118Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.13844142
119Neck muscle weakness (HP:0000467)2.11161093
120Abnormal hemoglobin (HP:0011902)2.10347031
121Striae distensae (HP:0001065)2.09032619
122Respiratory distress (HP:0002098)2.05313120
123Abnormality of purine metabolism (HP:0004352)2.01257872
124Tachypnea (HP:0002789)1.99787447
125Hypoalphalipoproteinemia (HP:0003233)1.95690442
126Glycosuria (HP:0003076)1.95586167
127Abnormality of urine glucose concentration (HP:0011016)1.95586167
128Vascular tortuosity (HP:0004948)1.95091384
129Delayed gross motor development (HP:0002194)1.94679803
130Frequent falls (HP:0002359)1.94353916
131Absent eyelashes (HP:0000561)1.93911718
132Infantile muscular hypotonia (HP:0008947)1.93226287
133Gliosis (HP:0002171)1.92878097
134Cerebral aneurysm (HP:0004944)1.92589257
135X-linked dominant inheritance (HP:0001423)1.90602874
136Facial diplegia (HP:0001349)1.90585782
137Large hands (HP:0001176)1.89681019
138Shallow orbits (HP:0000586)1.86402719
139Reduced subcutaneous adipose tissue (HP:0003758)1.85346369
140Neonatal onset (HP:0003623)1.84847115
141CNS demyelination (HP:0007305)1.83779314
142Prenatal maternal abnormality (HP:0002686)1.83020577
143Asymmetric septal hypertrophy (HP:0001670)1.82599268
144Gowers sign (HP:0003391)1.82343555
145Erythema (HP:0010783)1.80993668
146Foot dorsiflexor weakness (HP:0009027)1.80911418
147Atrioventricular block (HP:0001678)1.78089084
148Cavernous hemangioma (HP:0001048)1.76793259
149Cerebral hemorrhage (HP:0001342)1.76068032
150Congenital ichthyosiform erythroderma (HP:0007431)1.75822655
151Pancreatitis (HP:0001733)1.74721307
152Abnormality of glutamine family amino acid metabolism (HP:0010902)1.74002376
153Hepatosplenomegaly (HP:0001433)1.73855034
154Palmoplantar hyperkeratosis (HP:0000972)1.73222463
155Tinnitus (HP:0000360)1.73102512
156Neoplasm of the rectum (HP:0100743)1.72980750
157Easy fatigability (HP:0003388)1.72709234
158Xanthomatosis (HP:0000991)1.71431539
159Hyperglycemia (HP:0003074)1.71394391
160Premature rupture of membranes (HP:0001788)1.70755553
161Decreased circulating renin level (HP:0003351)1.70590088
162Increased connective tissue (HP:0009025)1.70401879
163Brushfield spots (HP:0001088)1.69520495
164Ankle contracture (HP:0006466)1.67980817
165Broad metatarsal (HP:0001783)1.67363179
166Increased mean platelet volume (HP:0011877)1.67072708
167Toxemia of pregnancy (HP:0100603)1.65743450
168Potter facies (HP:0002009)1.65580593
169Facial shape deformation (HP:0011334)1.65580593

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK46.07916856
2PDK36.07916856
3BCKDK6.07104957
4CAMK1D4.67904737
5TRIB34.44769514
6PDK24.04443611
7CAMK1G3.25794338
8NME23.13338335
9SIK12.95713954
10TESK12.58198382
11PKN22.27638976
12STK38L2.23121969
13PRKAA22.05571415
14LATS11.80834674
15CDK91.40845894
16EPHB11.37717575
17RIPK41.35027224
18TGFBR21.30213809
19LATS21.23139922
20ERN11.22077668
21PINK11.21697772
22STK241.19127859
23MOS1.13178774
24PRPF4B1.07564118
25TRPM71.07360223
26PDPK11.03994185
27CAMKK21.00636313
28IRAK30.99878200
29TIE10.99837146
30CSK0.98800472
31PIK3CA0.97448851
32NLK0.95682261
33PRKAA10.92483787
34STK30.91863812
35JAK30.86641181
36PRKD30.86553594
37EPHB20.86009894
38PDK10.85305485
39PTK20.83972313
40CDC42BPA0.83912159
41MAP2K10.79027328
42ZAP700.78435808
43FES0.77669995
44MAPKAPK30.73097984
45RIPK10.72844343
46TTN0.72581440
47ADRBK10.71245448
48TYK20.71076004
49LMTK20.70685788
50CDK40.66915967
51DAPK30.63291255
52PDGFRA0.63236038
53EEF2K0.62796108
54MAPK70.60986612
55NEK90.60954637
56IRAK10.60043779
57KSR20.58689541
58STK380.58340001
59ICK0.57601244
60CAMK10.57368115
61JAK10.57183100
62PAK20.56177111
63INSRR0.55512898
64MAPK30.55107424
65PDGFRB0.54869632
66MARK20.54464451
67PTK60.54271442
68KIT0.54141027
69MAP2K40.53536080
70PRKG10.53491126
71PRKACG0.53340457
72TYRO30.52186718
73EIF2AK20.51842834
74CAMKK10.51486878
75ABL20.50116083
76MAPKAPK50.49144888
77PRKCH0.48148052
78PHKG10.47902729
79PHKG20.47902729
80PLK40.47613132
81PRKD10.47196672
82MAPK120.46619048
83KDR0.45820651
84MAP3K10.44667913
85ILK0.43948191
86GSK3A0.43580298
87MAP3K90.43563758
88MYLK0.42562802
89SGK30.42458472
90FER0.42452175
91PKN10.42123607
92PRKACB0.41531407
93IGF1R0.41433363
94SGK20.40973161
95TGFBR10.40294085
96MST1R0.40257224
97MAPK110.39147715
98RPS6KA30.38919770
99MAP3K130.38727825
100JAK20.38087718
101PRKD20.37785404
102MAP3K70.35553352
103ABL10.35302192
104FGFR30.34991409
105CDK60.34587976
106AKT20.34511916
107RET0.33962032
108YES10.33021063
109MTOR0.30643269
110FLT30.30516839
111FRK0.30026076
112DAPK20.29956104
113INSR0.29458752
114TBK10.28021852
115FGFR40.26435862
116NTRK30.26337326
117LRRK20.25526774
118STK110.22896111
119PLK20.22216963
120STK390.20586968
121WNK40.20363243
122BMX0.20270939
123EPHA30.19381059
124RPS6KB10.18125463
125PRKCE0.18057820
126PRKACA0.17635368
127ARAF0.17095425
128MAPK40.16978832
129MAP3K60.15696892
130CDK50.15602637
131PRKCZ0.15168936
132GRK50.14404685
133TTK0.14091860
134CAMK2G0.13378704
135NEK10.12563861
136SGK2230.12535713
137SGK4940.12535713
138BCR0.12527022
139PTK2B0.12493767
140DDR20.12389059

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000206.35628669
2Propanoate metabolism_Homo sapiens_hsa006405.26962182
3Fatty acid biosynthesis_Homo sapiens_hsa000614.57111898
4Fatty acid metabolism_Homo sapiens_hsa012124.00864227
5Fatty acid degradation_Homo sapiens_hsa000713.69659024
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.57959049
7PPAR signaling pathway_Homo sapiens_hsa033203.25491559
8Fatty acid elongation_Homo sapiens_hsa000623.17324075
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.14385902
10Pyruvate metabolism_Homo sapiens_hsa006202.90633051
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.74792042
12Carbon metabolism_Homo sapiens_hsa012002.48056439
13Oxidative phosphorylation_Homo sapiens_hsa001902.37443634
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.30470189
15Parkinsons disease_Homo sapiens_hsa050122.25963970
16Caffeine metabolism_Homo sapiens_hsa002322.25304016
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.05474793
18Histidine metabolism_Homo sapiens_hsa003401.90939226
19Alzheimers disease_Homo sapiens_hsa050101.70995523
20Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.69013048
21Butanoate metabolism_Homo sapiens_hsa006501.64502327
22Huntingtons disease_Homo sapiens_hsa050161.63811164
23Sulfur metabolism_Homo sapiens_hsa009201.40836567
24Peroxisome_Homo sapiens_hsa041461.33779976
25Adipocytokine signaling pathway_Homo sapiens_hsa049201.31046701
26Cardiac muscle contraction_Homo sapiens_hsa042601.19351827
27beta-Alanine metabolism_Homo sapiens_hsa004101.18364401
28Glycerolipid metabolism_Homo sapiens_hsa005611.12284572
29AMPK signaling pathway_Homo sapiens_hsa041521.06210475
30Galactose metabolism_Homo sapiens_hsa000520.98912117
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95018869
32Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90685182
33Glucagon signaling pathway_Homo sapiens_hsa049220.88518651
34Insulin resistance_Homo sapiens_hsa049310.81343287
35Tryptophan metabolism_Homo sapiens_hsa003800.79908507
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78852182
37Cyanoamino acid metabolism_Homo sapiens_hsa004600.77504681
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74238811
39Biosynthesis of amino acids_Homo sapiens_hsa012300.69456922
40Insulin signaling pathway_Homo sapiens_hsa049100.69204996
41Fat digestion and absorption_Homo sapiens_hsa049750.63631486
42Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60777074
43Glycerophospholipid metabolism_Homo sapiens_hsa005640.58653414
44Malaria_Homo sapiens_hsa051440.57528685
45Metabolic pathways_Homo sapiens_hsa011000.51236397
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50394057
47Pentose phosphate pathway_Homo sapiens_hsa000300.44924927
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44647983
49Focal adhesion_Homo sapiens_hsa045100.44384715
50Nitrogen metabolism_Homo sapiens_hsa009100.42149271
51Renin-angiotensin system_Homo sapiens_hsa046140.41890547
52Lysine degradation_Homo sapiens_hsa003100.41362446
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39304400
54Vitamin B6 metabolism_Homo sapiens_hsa007500.38321796
55Arginine and proline metabolism_Homo sapiens_hsa003300.31816759
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.31590813
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27398675
58Staphylococcus aureus infection_Homo sapiens_hsa051500.26566866
59Starch and sucrose metabolism_Homo sapiens_hsa005000.25431337
60Protein digestion and absorption_Homo sapiens_hsa049740.24953813
61Complement and coagulation cascades_Homo sapiens_hsa046100.24195162
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.21899143
63Ovarian steroidogenesis_Homo sapiens_hsa049130.21428745
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.19784434
65GnRH signaling pathway_Homo sapiens_hsa049120.19101967
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.16902614
67Renin secretion_Homo sapiens_hsa049240.16823890
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16820579
69Glutathione metabolism_Homo sapiens_hsa004800.16746084
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.15499809
71Arachidonic acid metabolism_Homo sapiens_hsa005900.14743767
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.14630155
73Morphine addiction_Homo sapiens_hsa050320.14041143
74HIF-1 signaling pathway_Homo sapiens_hsa040660.14040862
75Melanogenesis_Homo sapiens_hsa049160.13207528
76Folate biosynthesis_Homo sapiens_hsa007900.12720280
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.11776729
78Pertussis_Homo sapiens_hsa051330.10134313
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.08479983
80Sulfur relay system_Homo sapiens_hsa041220.07365179
81Bile secretion_Homo sapiens_hsa049760.07302392
82Estrogen signaling pathway_Homo sapiens_hsa049150.06725529
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.06634390
84Salivary secretion_Homo sapiens_hsa049700.06575253
85Chemical carcinogenesis_Homo sapiens_hsa052040.05943259
86mTOR signaling pathway_Homo sapiens_hsa041500.05833133
87Notch signaling pathway_Homo sapiens_hsa043300.05808881
88Thyroid cancer_Homo sapiens_hsa052160.05600916
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.05600835
90Prolactin signaling pathway_Homo sapiens_hsa049170.05374574
91Dorso-ventral axis formation_Homo sapiens_hsa043200.05328622
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.05203244
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.04676293
94Proteoglycans in cancer_Homo sapiens_hsa052050.04472999
95Dilated cardiomyopathy_Homo sapiens_hsa054140.04283121
96Long-term potentiation_Homo sapiens_hsa047200.04027697
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.03600302
98Fructose and mannose metabolism_Homo sapiens_hsa000510.03499562
99Rap1 signaling pathway_Homo sapiens_hsa040150.03141022
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.03104386
101Linoleic acid metabolism_Homo sapiens_hsa005910.02922345
102Gastric acid secretion_Homo sapiens_hsa049710.01574463
103Steroid biosynthesis_Homo sapiens_hsa001000.01036206
104Viral myocarditis_Homo sapiens_hsa054160.00869805
105Vitamin digestion and absorption_Homo sapiens_hsa049770.00671903
106Arginine biosynthesis_Homo sapiens_hsa002200.00116759
107Choline metabolism in cancer_Homo sapiens_hsa05231-0.1248481
108Protein export_Homo sapiens_hsa03060-0.1220722
109Calcium signaling pathway_Homo sapiens_hsa04020-0.1186749
110Legionellosis_Homo sapiens_hsa05134-0.1074706
111ECM-receptor interaction_Homo sapiens_hsa04512-0.0981213
112Acute myeloid leukemia_Homo sapiens_hsa05221-0.0919191
113Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.0805492
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.0790355
115FoxO signaling pathway_Homo sapiens_hsa04068-0.0753804
116Small cell lung cancer_Homo sapiens_hsa05222-0.0746460
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410-0.0704890
118Tyrosine metabolism_Homo sapiens_hsa00350-0.0618875
119Other types of O-glycan biosynthesis_Homo sapiens_hsa00514-0.0547839
120cAMP signaling pathway_Homo sapiens_hsa04024-0.0526501
121Phenylalanine metabolism_Homo sapiens_hsa00360-0.0520805
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760-0.0503934
123Phospholipase D signaling pathway_Homo sapiens_hsa04072-0.0490959
124Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261-0.0465634
125Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.0453723
126Type II diabetes mellitus_Homo sapiens_hsa04930-0.0383263
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250-0.0347753
128ABC transporters_Homo sapiens_hsa02010-0.0343990
129Cysteine and methionine metabolism_Homo sapiens_hsa00270-0.0250573
130Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.0140228
131Retinol metabolism_Homo sapiens_hsa00830-0.0011485

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