CIDEB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.33533845
2L-phenylalanine catabolic process (GO:0006559)7.33533845
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.07682845
4L-phenylalanine metabolic process (GO:0006558)7.07682845
5aromatic amino acid family catabolic process (GO:0009074)6.67592687
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.30755248
7indole-containing compound catabolic process (GO:0042436)6.09331519
8indolalkylamine catabolic process (GO:0046218)6.09331519
9tryptophan catabolic process (GO:0006569)6.09331519
10glyoxylate metabolic process (GO:0046487)5.93828042
11kynurenine metabolic process (GO:0070189)5.88338489
12epoxygenase P450 pathway (GO:0019373)5.74131398
13tryptophan metabolic process (GO:0006568)5.72111210
14bile acid biosynthetic process (GO:0006699)5.64849099
15cysteine metabolic process (GO:0006534)5.52979058
16high-density lipoprotein particle remodeling (GO:0034375)5.45267760
17alpha-linolenic acid metabolic process (GO:0036109)5.38483044
18urea metabolic process (GO:0019627)5.36965594
19urea cycle (GO:0000050)5.36965594
20sulfur amino acid catabolic process (GO:0000098)5.31559749
21negative regulation of fibrinolysis (GO:0051918)5.18658611
22serine family amino acid catabolic process (GO:0009071)5.09839489
23fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.98474637
24peptidyl-glutamic acid carboxylation (GO:0017187)4.97926106
25protein carboxylation (GO:0018214)4.97926106
26regulation of fibrinolysis (GO:0051917)4.97499951
27regulation of cholesterol esterification (GO:0010872)4.96732415
28lysine catabolic process (GO:0006554)4.96084652
29lysine metabolic process (GO:0006553)4.96084652
30nitrogen cycle metabolic process (GO:0071941)4.95311329
31bile acid metabolic process (GO:0008206)4.88672670
32aromatic amino acid family metabolic process (GO:0009072)4.86530146
33reverse cholesterol transport (GO:0043691)4.85629819
34regulation of triglyceride catabolic process (GO:0010896)4.84606515
35regulation of protein activation cascade (GO:2000257)4.80386322
36complement activation, alternative pathway (GO:0006957)4.79932596
37homocysteine metabolic process (GO:0050667)4.76971620
38protein-lipid complex remodeling (GO:0034368)4.74322607
39macromolecular complex remodeling (GO:0034367)4.74322607
40plasma lipoprotein particle remodeling (GO:0034369)4.74322607
41phospholipid efflux (GO:0033700)4.66469262
42amino-acid betaine metabolic process (GO:0006577)4.66341878
43negative regulation of sterol transport (GO:0032372)4.62406720
44negative regulation of cholesterol transport (GO:0032375)4.62406720
45cellular ketone body metabolic process (GO:0046950)4.57307689
46alpha-amino acid catabolic process (GO:1901606)4.56670559
47tyrosine metabolic process (GO:0006570)4.56182345
48regulation of complement activation (GO:0030449)4.47911670
49triglyceride homeostasis (GO:0070328)4.46930755
50acylglycerol homeostasis (GO:0055090)4.46930755
51regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.39972592
52drug catabolic process (GO:0042737)4.38577837
53bile acid and bile salt transport (GO:0015721)4.35431081
54indolalkylamine metabolic process (GO:0006586)4.30964522
55glutamate metabolic process (GO:0006536)4.29403126
56cellular glucuronidation (GO:0052695)4.27537980
57blood coagulation, intrinsic pathway (GO:0007597)4.26376598
58cellular amino acid catabolic process (GO:0009063)4.25919415
59amine catabolic process (GO:0009310)4.22075773
60cellular biogenic amine catabolic process (GO:0042402)4.22075773
61serine family amino acid metabolic process (GO:0009069)4.21859230
62plasma lipoprotein particle clearance (GO:0034381)4.21710644
63coenzyme catabolic process (GO:0009109)4.21031436
64cellular modified amino acid catabolic process (GO:0042219)4.20439264
65protein-lipid complex subunit organization (GO:0071825)4.18326140
66glycine metabolic process (GO:0006544)4.16924049
67omega-hydroxylase P450 pathway (GO:0097267)4.15967177
68cholesterol efflux (GO:0033344)4.13540706
69drug metabolic process (GO:0017144)4.12002537
70benzene-containing compound metabolic process (GO:0042537)4.11081748
71plasma lipoprotein particle assembly (GO:0034377)4.02333662
72serine family amino acid biosynthetic process (GO:0009070)4.01662214
73drug transmembrane transport (GO:0006855)4.01583212
74acute-phase response (GO:0006953)4.00267557
75ethanol oxidation (GO:0006069)3.98185652
76dicarboxylic acid biosynthetic process (GO:0043650)3.96442619
77imidazole-containing compound metabolic process (GO:0052803)3.96054440
78ketone body metabolic process (GO:1902224)3.95636469
79urate metabolic process (GO:0046415)3.95285277
80low-density lipoprotein particle remodeling (GO:0034374)3.94179562
81angiotensin maturation (GO:0002003)3.93649576
82arginine metabolic process (GO:0006525)3.92611661
83short-chain fatty acid metabolic process (GO:0046459)3.92361525
84aldehyde catabolic process (GO:0046185)3.90777776
85positive regulation of triglyceride lipase activity (GO:0061365)3.89756233
86positive regulation of lipoprotein lipase activity (GO:0051006)3.89756233
87protein activation cascade (GO:0072376)3.85931202
88uronic acid metabolic process (GO:0006063)3.85625535
89glucuronate metabolic process (GO:0019585)3.85625535
90regulation of plasminogen activation (GO:0010755)3.83232746
91regulation of bile acid biosynthetic process (GO:0070857)3.82008313
92positive regulation of fatty acid biosynthetic process (GO:0045723)3.81100911
93regulation of humoral immune response (GO:0002920)3.80413976
94exogenous drug catabolic process (GO:0042738)3.78526117
95flavonoid metabolic process (GO:0009812)3.76925511
96organic acid catabolic process (GO:0016054)3.75656884
97carboxylic acid catabolic process (GO:0046395)3.75656884
98fibrinolysis (GO:0042730)3.72616103
99cholesterol homeostasis (GO:0042632)3.72500104
100regulation of cholesterol homeostasis (GO:2000188)3.72459256
101acetyl-CoA metabolic process (GO:0006084)3.69764075
102complement activation, classical pathway (GO:0006958)3.68288696
103very-low-density lipoprotein particle assembly (GO:0034379)3.68255505
104sterol homeostasis (GO:0055092)3.67914751
105ethanol metabolic process (GO:0006067)3.67134638
106positive regulation of lipid catabolic process (GO:0050996)3.66521955
107phospholipid homeostasis (GO:0055091)3.66464110
108fat-soluble vitamin biosynthetic process (GO:0042362)3.66316606
109intestinal cholesterol absorption (GO:0030299)3.65508271
110aspartate family amino acid catabolic process (GO:0009068)3.65090217
111complement activation (GO:0006956)3.64246464
112intestinal absorption (GO:0050892)3.64000231
113plasma lipoprotein particle organization (GO:0071827)3.63801453
114protein-lipid complex assembly (GO:0065005)3.62001646
115diacylglycerol metabolic process (GO:0046339)3.61712310
116lipoprotein metabolic process (GO:0042157)3.61452499
117lipoprotein transport (GO:0042953)3.58812760
118cofactor catabolic process (GO:0051187)3.58030212
119negative regulation of lipase activity (GO:0060192)3.56936414
120carnitine metabolic process (GO:0009437)3.50485550
121fatty acid oxidation (GO:0019395)3.49217518
122negative regulation of blood coagulation (GO:0030195)3.46253870
123negative regulation of hemostasis (GO:1900047)3.46253870
124disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.40447658
125killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.40447658
126hormone catabolic process (GO:0042447)3.33034562
127negative regulation of protein activation cascade (GO:2000258)3.26714882
128positive regulation of hemostasis (GO:1900048)3.14416873
129positive regulation of blood coagulation (GO:0030194)3.14416873
130regulation of apoptotic cell clearance (GO:2000425)3.12019728
131alkaloid metabolic process (GO:0009820)3.12007066
132positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.11880008
133negative regulation of coagulation (GO:0050819)3.11001903
134phenylpropanoid metabolic process (GO:0009698)3.10311085
135acute inflammatory response (GO:0002526)3.06663592
136antigen processing and presentation of endogenous antigen (GO:0019883)3.05168609
137detection of bacterium (GO:0016045)3.03917473
138regulation of lipoprotein particle clearance (GO:0010984)3.01404294
139cytolysis (GO:0019835)3.01376781
140detection of other organism (GO:0098543)2.96181777
141negative regulation of wound healing (GO:0061045)2.94174630
142negative regulation of cell killing (GO:0031342)2.89384896
143negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.89384896

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.20047697
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.09785127
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.69352960
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.34668270
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.05517971
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.99974068
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.80784800
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.88426165
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.77642012
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.10391710
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.38422359
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.23185559
13TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.04406304
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04398638
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.6651518
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91892863
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.80363739
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.79837850
19* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.74539940
20IRF8_27001747_Chip-Seq_BMDM_Mouse1.70502580
21* VDR_21846776_ChIP-Seq_THP-1_Human1.69452784
22* FOXA2_19822575_ChIP-Seq_HepG2_Human1.58184096
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57842406
24CLOCK_20551151_ChIP-Seq_293T_Human1.57812642
25* VDR_24763502_ChIP-Seq_THP-1_Human1.55450736
26CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.50283395
27RUNX_20019798_ChIP-Seq_JUKART_Human1.47094210
28BCL6_27268052_Chip-Seq_Bcells_Human1.46462890
29HNF4A_19822575_ChIP-Seq_HepG2_Human1.46428480
30GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.43650706
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42476586
32HTT_18923047_ChIP-ChIP_STHdh_Human1.41251788
33CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.40838437
34SPI1_23547873_ChIP-Seq_NB4_Human1.39979511
35BCOR_27268052_Chip-Seq_Bcells_Human1.39705693
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36841775
37STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.35711570
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31480926
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30969900
40UTX_26944678_Chip-Seq_JUKART_Human1.30448937
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.30193781
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.29808012
43GATA1_22025678_ChIP-Seq_K562_Human1.28986821
44SPI1_23127762_ChIP-Seq_K562_Human1.28552544
45MAF_26560356_Chip-Seq_TH1_Human1.26437659
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26252459
47SCL_19346495_ChIP-Seq_HPC-7_Human1.24545353
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24481808
49* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23839679
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22969811
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21609337
52STAT4_19710469_ChIP-ChIP_TH1__Mouse1.21410696
53MYB_21317192_ChIP-Seq_ERMYB_Mouse1.20908396
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19856751
55ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17984135
56* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16405368
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16163678
58IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15665822
59SOX2_27498859_Chip-Seq_STOMACH_Mouse1.15049544
60TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15033232
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14616660
62RXRA_24833708_ChIP-Seq_LIVER_Mouse1.14138565
63MYB_26560356_Chip-Seq_TH1_Human1.10941314
64P68_20966046_ChIP-Seq_HELA_Human1.08293471
65SA1_27219007_Chip-Seq_Bcells_Human1.08072568
66STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.07585432
67MYB_26560356_Chip-Seq_TH2_Human1.06659141
68E2F1_20622854_ChIP-Seq_HELA_Human1.05687556
69P300_27268052_Chip-Seq_Bcells_Human1.04935092
70FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.03294666
71ELF1_20517297_ChIP-Seq_JURKAT_Human1.01732009
72RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01625119
73GATA4_25053715_ChIP-Seq_YYC3_Human1.01405405
74CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01031267
75TCF7_22412390_ChIP-Seq_EML_Mouse1.00827221
76PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00757267
77SPI1_20517297_ChIP-Seq_HL60_Human0.99178712
78* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99134872
79ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97589449
80CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97153436
81MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97047064
82ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96664156
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95426690
84SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94853738
85* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93996378
86SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93931400
87MAF_26560356_Chip-Seq_TH2_Human0.93702423
88FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.93436118
89GATA3_27048872_Chip-Seq_THYMUS_Human0.93123736
90STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91183746
91PHF8_20622854_ChIP-Seq_HELA_Human0.90735746
92PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90590481
93* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89914489
94CDX2_20551321_ChIP-Seq_CACO-2_Human0.85992219
95IRF8_22096565_ChIP-ChIP_GC-B_Human0.85266301
96ESR2_21235772_ChIP-Seq_MCF-7_Human0.81659381
97BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81570793
98AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80354182
99NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.80046588
100KAP1_22055183_ChIP-Seq_ESCs_Mouse0.79963949
101RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.77091741
102SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.74755245
103ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.73495603
104SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.73418199
105AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.72537711
106RAD21_21589869_ChIP-Seq_MESCs_Mouse0.72368109
107* RARA_24833708_ChIP-Seq_LIVER_Mouse0.72001610
108Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.71650089
109NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.69983515
110SALL4_18804426_ChIP-ChIP_XEN_Mouse0.69578494
111BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.69430539
112CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.67251096
113LXR_22292898_ChIP-Seq_THP-1_Human0.67140050
114ESR1_21235772_ChIP-Seq_MCF-7_Human0.65945433
115NRF2_20460467_ChIP-Seq_MEFs_Mouse0.63700469
116NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.63700469
117ZNF263_19887448_ChIP-Seq_K562_Human0.63501092
118STAT3_1855785_ChIP-Seq_MESCs_Mouse0.61956312
119EGR1_19032775_ChIP-ChIP_M12_Human0.60271797
120PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.60116087
121CEBPB_22108803_ChIP-Seq_LS180_Human0.59767299
122RARB_24833708_ChIP-Seq_LIVER_Mouse0.59353036
123GATA6_25053715_ChIP-Seq_YYC3_Human0.57421969
124* MYC_19915707_ChIP-ChIP_AK7_Human0.56655869
125AR_20517297_ChIP-Seq_VCAP_Human0.56520357
126FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.53803696
127FOXA1_25552417_ChIP-Seq_VCAP_Human0.53138096
128FOXO3_23340844_ChIP-Seq_DLD1_Human0.52119786
129PPAR_26484153_Chip-Seq_NCI-H1993_Human0.52111690
130ESET_19884257_ChIP-Seq_ESCs_Mouse0.51611730
131SOX2_20726797_ChIP-Seq_SW620_Human0.50619874
132TAF2_19829295_ChIP-Seq_ESCs_Human0.50510920
133STAT1_17558387_ChIP-Seq_HELA_Human0.50112766
134SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.48498671
135CBP_21632823_ChIP-Seq_H3396_Human0.48120674
136* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.47769600
137GATA2_19941826_ChIP-Seq_K562_Human0.47590329
138PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.47429333
139P53_21459846_ChIP-Seq_SAOS-2_Human0.46059128
140FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.45626002
141ERG_21242973_ChIP-ChIP_JURKAT_Human0.45454982
142FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.44512065
143GATA1_19941826_ChIP-Seq_K562_Human0.44229311
144ESR1_20079471_ChIP-ChIP_T-47D_Human0.44015086
145* GATA1_19941827_ChIP-Seq_MEL_Mouse0.43533281
146PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.43061386
147SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.41842998
148EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.41112612
149BCAT_22108803_ChIP-Seq_LS180_Human0.41055434
150RACK7_27058665_Chip-Seq_MCF-7_Human0.40661186
151STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.40267767
152SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40267127
153CDX2_22108803_ChIP-Seq_LS180_Human0.39089391
154CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.39062436
155ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.38573950
156MYC_27129775_Chip-Seq_CORNEA_Mouse0.38400195
157GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.38299222
158P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.38275113
159CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.37385644
160FOXH1_21741376_ChIP-Seq_EPCs_Human0.37131228
161EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.37038491

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.22832375
2MP0005360_urolithiasis8.05010740
3MP0005085_abnormal_gallbladder_physiolo6.15963983
4MP0005365_abnormal_bile_salt5.90246558
5MP0008875_abnormal_xenobiotic_pharmacok5.04793834
6MP0003806_abnormal_nucleotide_metabolis4.06649456
7MP0003252_abnormal_bile_duct3.86808582
8MP0010329_abnormal_lipoprotein_level3.47476472
9MP0009840_abnormal_foam_cell3.34964493
10MP0005332_abnormal_amino_acid3.03003465
11MP0003195_calcinosis2.82655284
12MP0001666_abnormal_nutrient_absorption2.79695564
13MP0005083_abnormal_biliary_tract2.73651142
14MP0004019_abnormal_vitamin_homeostasis2.52365781
15MP0003191_abnormal_cellular_cholesterol2.38651008
16MP0003183_abnormal_peptide_metabolism2.17445042
17MP0002138_abnormal_hepatobiliary_system2.09115674
18MP0000609_abnormal_liver_physiology2.05324402
19* MP0002118_abnormal_lipid_homeostasis2.02785519
20MP0002132_abnormal_respiratory_system1.92206727
21MP0005319_abnormal_enzyme/_coenzyme1.82308683
22MP0003868_abnormal_feces_composition1.79445615
23MP0001835_abnormal_antigen_presentation1.69708873
24MP0005025_abnormal_response_to1.68201323
25MP0003303_peritoneal_inflammation1.68181050
26MP0001764_abnormal_homeostasis1.65732424
27MP0009785_altered_susceptibility_to1.65620586
28MP0002419_abnormal_innate_immunity1.63149665
29MP0010155_abnormal_intestine_physiology1.61135414
30MP0005584_abnormal_enzyme/coenzyme_acti1.59870248
31MP0009643_abnormal_urine_homeostasis1.55144944
32MP0005451_abnormal_body_composition1.53555456
33MP0000685_abnormal_immune_system1.46202662
34MP0005387_immune_system_phenotype1.44705261
35MP0001790_abnormal_immune_system1.44705261
36MP0009697_abnormal_copulation1.42838568
37MP0001800_abnormal_humoral_immune1.41046330
38MP0003172_abnormal_lysosome_physiology1.33536295
39MP0003186_abnormal_redox_activity1.31307189
40MP0005671_abnormal_response_to1.30069215
41MP0003866_abnormal_defecation1.26453807
42MP0005000_abnormal_immune_tolerance1.25539449
43MP0003011_delayed_dark_adaptation1.24398759
44MP0002723_abnormal_immune_serum1.18938243
45MP0005636_abnormal_mineral_homeostasis1.16583843
46MP0001533_abnormal_skeleton_physiology1.15730677
47MP0003656_abnormal_erythrocyte_physiolo1.12037203
48MP0000598_abnormal_liver_morphology1.10303804
49MP0003705_abnormal_hypodermis_morpholog1.08531958
50MP0002148_abnormal_hypersensitivity_rea1.05967774
51MP0009764_decreased_sensitivity_to1.05465212
52MP0000604_amyloidosis1.05396250
53MP0001819_abnormal_immune_cell1.04495590
54MP0002420_abnormal_adaptive_immunity1.04056051
55MP0002452_abnormal_antigen_presenting1.03482764
56MP0009333_abnormal_splenocyte_physiolog1.03394827
57MP0005647_abnormal_sex_gland1.02550531
58MP0002254_reproductive_system_inflammat0.96928921
59MP0001986_abnormal_taste_sensitivity0.94408942
60MP0009763_increased_sensitivity_to0.91237391
61MP0005084_abnormal_gallbladder_morpholo0.90420414
62* MP0009642_abnormal_blood_homeostasis0.88317580
63MP0002876_abnormal_thyroid_physiology0.88243973
64MP0008469_abnormal_protein_level0.88115481
65MP0006036_abnormal_mitochondrial_physio0.87481159
66MP0002405_respiratory_system_inflammati0.86234330
67MP0005670_abnormal_white_adipose0.85264279
68MP0001756_abnormal_urination0.83340006
69MP0004147_increased_porphyrin_level0.81994994
70MP0002396_abnormal_hematopoietic_system0.81864105
71MP0000716_abnormal_immune_system0.81028986
72MP0001545_abnormal_hematopoietic_system0.79845072
73MP0005397_hematopoietic_system_phenotyp0.79845072
74MP0005408_hypopigmentation0.78251568
75MP0001663_abnormal_digestive_system0.78182713
76MP0000465_gastrointestinal_hemorrhage0.77925964
77MP0005376_homeostasis/metabolism_phenot0.77675275
78MP0010368_abnormal_lymphatic_system0.77038421
79MP0005377_hearing/vestibular/ear_phenot0.76485650
80MP0003878_abnormal_ear_physiology0.76485650
81MP0003879_abnormal_hair_cell0.76240804
82MP0009379_abnormal_foot_pigmentation0.75897742
83MP0000858_altered_metastatic_potential0.75613471
84MP0008260_abnormal_autophagy0.75342738
85MP0004043_abnormal_pH_regulation0.75095120
86MP0005164_abnormal_response_to0.74811535
87MP0009765_abnormal_xenobiotic_induced0.73575997
88* MP0002078_abnormal_glucose_homeostasis0.72481508
89* MP0000689_abnormal_spleen_morphology0.72228061
90MP0002136_abnormal_kidney_physiology0.71026227
91MP0002398_abnormal_bone_marrow0.70753959
92MP0001851_eye_inflammation0.70124789
93MP0002971_abnormal_brown_adipose0.69929052
94MP0005535_abnormal_body_temperature0.69205521
95MP0005409_darkened_coat_color0.67572262
96MP0002166_altered_tumor_susceptibility0.67223193
97MP0003329_amyloid_beta_deposits0.67206102
98MP0003690_abnormal_glial_cell0.65532417
99MP0002822_catalepsy0.65435644
100* MP0002722_abnormal_immune_system0.64770421
101MP0002429_abnormal_blood_cell0.64551543
102MP0004947_skin_inflammation0.63850097
103MP0005266_abnormal_metabolism0.62841954
104MP0005220_abnormal_exocrine_pancreas0.62389323
105MP0009053_abnormal_anal_canal0.61676267
106MP0001661_extended_life_span0.60658846
107MP0004130_abnormal_muscle_cell0.57321855
108* MP0005334_abnormal_fat_pad0.56758856
109MP0005448_abnormal_energy_balance0.55980530
110MP0006035_abnormal_mitochondrial_morpho0.55372932
111MP0003638_abnormal_response/metabolism_0.52686397
112MP0001765_abnormal_ion_homeostasis0.50802599
113MP0005395_other_phenotype0.49053625
114MP0005058_abnormal_lysosome_morphology0.48075291
115MP0005666_abnormal_adipose_tissue0.47894379
116MP0000639_abnormal_adrenal_gland0.47342724
117MP0003718_maternal_effect0.45451094
118MP0005464_abnormal_platelet_physiology0.45318602
119MP0002796_impaired_skin_barrier0.44719926
120MP0005166_decreased_susceptibility_to0.44717125
121MP0003075_altered_response_to0.44404920
122MP0002928_abnormal_bile_duct0.44069131
123MP0004264_abnormal_extraembryonic_tissu0.43497974
124MP0008873_increased_physiological_sensi0.43039656
125MP0008872_abnormal_physiological_respon0.42884912
126MP0003724_increased_susceptibility_to0.42194382
127MP0004782_abnormal_surfactant_physiolog0.41641601
128MP0008874_decreased_physiological_sensi0.40816951
129MP0000230_abnormal_systemic_arterial0.40377871
130* MP0003953_abnormal_hormone_level0.40211877
131MP0000538_abnormal_urinary_bladder0.36703067
132MP0003436_decreased_susceptibility_to0.34409975
133MP0005167_abnormal_blood-brain_barrier0.33703893
134MP0002168_other_aberrant_phenotype0.33514136
135MP0009672_abnormal_birth_weight0.32107124
136MP0009384_cardiac_valve_regurgitation0.31784267
137MP0005248_abnormal_Harderian_gland0.31709452
138MP0010234_abnormal_vibrissa_follicle0.31383520
139MP0001845_abnormal_inflammatory_respons0.30393365
140MP0006082_CNS_inflammation0.30385703
141MP0000249_abnormal_blood_vessel0.29892519
142MP0002837_dystrophic_cardiac_calcinosis0.29873944
143MP0002135_abnormal_kidney_morphology0.29268101
144MP0000579_abnormal_nail_morphology0.26954182
145MP0003300_gastrointestinal_ulcer0.26354784
146MP0004883_abnormal_blood_vessel0.25793986
147MP0001881_abnormal_mammary_gland0.25294764

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.09099359
2Intrahepatic cholestasis (HP:0001406)6.86402937
3Deep venous thrombosis (HP:0002625)6.74628301
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.33647831
5Xanthomatosis (HP:0000991)6.06169237
6Hypobetalipoproteinemia (HP:0003563)6.04344119
7Prolonged partial thromboplastin time (HP:0003645)5.91427925
8Hyperlipoproteinemia (HP:0010980)5.22020650
9Complement deficiency (HP:0004431)4.75139351
10Abnormality of glutamine family amino acid metabolism (HP:0010902)4.73303570
11Hyperammonemia (HP:0001987)4.64812418
12Hypolipoproteinemia (HP:0010981)4.56905471
13Hyperglycinuria (HP:0003108)4.48369254
14Hyperglycinemia (HP:0002154)4.45904467
15Joint hemorrhage (HP:0005261)4.43427282
16Ketosis (HP:0001946)4.39556900
17Abnormality of sulfur amino acid metabolism (HP:0004339)4.28833295
18Abnormality of glycine metabolism (HP:0010895)4.27882049
19Abnormality of serine family amino acid metabolism (HP:0010894)4.27882049
20Abnormality of aspartate family amino acid metabolism (HP:0010899)4.24905086
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.15071521
22Epidermoid cyst (HP:0200040)4.04511666
23Hypoalphalipoproteinemia (HP:0003233)4.01225604
24Abnormality of the common coagulation pathway (HP:0010990)4.00192214
25Fat malabsorption (HP:0002630)3.98600336
26Abnormality of methionine metabolism (HP:0010901)3.94011684
27Hypoglycemic coma (HP:0001325)3.85973077
28Abnormality of pyrimidine metabolism (HP:0004353)3.65229924
29Abnormality of fatty-acid metabolism (HP:0004359)3.59520439
30Conjugated hyperbilirubinemia (HP:0002908)3.55894003
31Myositis (HP:0100614)3.45561838
32Eczematoid dermatitis (HP:0000976)3.45384883
33Abnormality of complement system (HP:0005339)3.44180558
34Abnormality of the intrinsic pathway (HP:0010989)3.40815427
35Hypercholesterolemia (HP:0003124)3.36933570
36Abnormality of nucleobase metabolism (HP:0010932)3.35479830
37Ketoacidosis (HP:0001993)3.34658076
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.33478162
39Purpura (HP:0000979)3.31510464
40Orchitis (HP:0100796)3.27320449
41Hyperbilirubinemia (HP:0002904)3.23502060
42Delayed CNS myelination (HP:0002188)3.21335637
43Abnormality of purine metabolism (HP:0004352)3.20604783
44Gout (HP:0001997)3.17243646
45Abnormality of serum amino acid levels (HP:0003112)3.01327104
46Retrobulbar optic neuritis (HP:0100654)3.00334476
47Optic neuritis (HP:0100653)3.00334476
48Pulmonary embolism (HP:0002204)2.99347280
49Metabolic acidosis (HP:0001942)2.97796692
50Steatorrhea (HP:0002570)2.94288979
51Hepatocellular carcinoma (HP:0001402)2.86117201
52Abnormality of dicarboxylic acid metabolism (HP:0010995)2.85309132
53Dicarboxylic aciduria (HP:0003215)2.85309132
54Vascular calcification (HP:0004934)2.78783763
55Epistaxis (HP:0000421)2.78699423
56Lethargy (HP:0001254)2.74908292
57Gastrointestinal infarctions (HP:0005244)2.74156390
58Spontaneous abortion (HP:0005268)2.73998566
59Malnutrition (HP:0004395)2.73155119
60Nephritis (HP:0000123)2.72616818
61Recurrent abscess formation (HP:0002722)2.71814351
62Abnormality of macrophages (HP:0004311)2.70659809
63Myocardial infarction (HP:0001658)2.65728726
64Systemic lupus erythematosus (HP:0002725)2.59066340
65Generalized aminoaciduria (HP:0002909)2.57990001
66Hypochromic microcytic anemia (HP:0004840)2.56998226
67Prolonged bleeding time (HP:0003010)2.47509899
68Cardiovascular calcification (HP:0011915)2.46377006
69Gangrene (HP:0100758)2.45549065
70Joint swelling (HP:0001386)2.45235771
71Skin nodule (HP:0200036)2.44105865
72Irritability (HP:0000737)2.43111308
73Proximal tubulopathy (HP:0000114)2.42965829
74Abnormality of proline metabolism (HP:0010907)2.42120338
75Hydroxyprolinuria (HP:0003080)2.42120338
76Cerebral edema (HP:0002181)2.41421934
77Acanthocytosis (HP:0001927)2.40381896
78Spastic diplegia (HP:0001264)2.39969186
79Obstructive lung disease (HP:0006536)2.39457466
80Chronic obstructive pulmonary disease (HP:0006510)2.39457466
81Recurrent bacterial skin infections (HP:0005406)2.37539891
82Hypoglycemic seizures (HP:0002173)2.37318218
83Meningitis (HP:0001287)2.35783824
84Neonatal onset (HP:0003623)2.34878621
85Elevated erythrocyte sedimentation rate (HP:0003565)2.33650404
86Sensorimotor neuropathy (HP:0007141)2.32998163
87Hypochromic anemia (HP:0001931)2.32474301
88Alkalosis (HP:0001948)2.31891284
89Late onset (HP:0003584)2.30548540
90Increased purine levels (HP:0004368)2.30168568
91Hyperuricemia (HP:0002149)2.30168568
92Vomiting (HP:0002013)2.29830490
93Widely patent fontanelles and sutures (HP:0004492)2.28778730
94Cholecystitis (HP:0001082)2.28240538
95Abnormal gallbladder physiology (HP:0012438)2.28240538
96Abnormality of iron homeostasis (HP:0011031)2.28077914
97Abnormal gallbladder morphology (HP:0012437)2.27690071
98Vasculitis (HP:0002633)2.26944141
99Anorexia (HP:0002039)2.25772786
100Increased serum ferritin (HP:0003281)2.25425673
101Enlarged kidneys (HP:0000105)2.24947629
102Cholelithiasis (HP:0001081)2.24038629
103Amyloidosis (HP:0011034)2.23189699
104Pancreatitis (HP:0001733)2.22361081
105Mitral stenosis (HP:0001718)2.22041291
106Encephalitis (HP:0002383)2.20303248
107Glycosuria (HP:0003076)2.20032221
108Abnormality of urine glucose concentration (HP:0011016)2.20032221
109Rickets (HP:0002748)2.18204908
110Glomerulonephritis (HP:0000099)2.16920759
111Pigmentary retinal degeneration (HP:0001146)2.14120471
112Keratoconjunctivitis sicca (HP:0001097)2.10226911
113Esophageal varix (HP:0002040)2.10209932
114Facial shape deformation (HP:0011334)2.07661539
115Potter facies (HP:0002009)2.07661539
116Recurrent gram-negative bacterial infections (HP:0005420)2.06641041
117Brushfield spots (HP:0001088)2.02685918
118Hypophosphatemia (HP:0002148)2.00307994
119Opisthotonus (HP:0002179)1.99900056
120Gingivitis (HP:0000230)1.99775866
121Recurrent skin infections (HP:0001581)1.99436862
122Menorrhagia (HP:0000132)1.97700443
123Keratoconjunctivitis (HP:0001096)1.97686626
124Osteomalacia (HP:0002749)1.97391490
125Abnormal enzyme/coenzyme activity (HP:0012379)1.97086608
126Arterial thrombosis (HP:0004420)1.95332515
127Gingival bleeding (HP:0000225)1.95017417
128Thrombophlebitis (HP:0004418)1.93903768
129Hypophosphatemic rickets (HP:0004912)1.93548714
130Abnormality of the gallbladder (HP:0005264)1.92369098
131Hemorrhage of the eye (HP:0011885)1.92030487
132Hyperinsulinemic hypoglycemia (HP:0000825)1.91295652
133Hyperphosphaturia (HP:0003109)1.91125887
134Abnormal cartilage morphology (HP:0002763)1.89007054
135Pulmonary infiltrates (HP:0002113)1.88708097
136Poikilocytosis (HP:0004447)1.87443936
137Abnormality of vitamin metabolism (HP:0100508)1.86812778
138Abnormal delayed hypersensitivity skin test (HP:0002963)1.86704155
139Confusion (HP:0001289)1.86542921
140Petechiae (HP:0000967)1.84622561
141Abnormality of alkaline phosphatase activity (HP:0004379)1.84088350
142Abnormality of transition element cation homeostasis (HP:0011030)1.84064555
143Recurrent fungal infections (HP:0002841)1.83462490
144Nausea (HP:0002018)1.83156059
145Skin rash (HP:0000988)1.82170349
146Pustule (HP:0200039)1.81592105
147Peritonitis (HP:0002586)1.81054984
148Mediastinal lymphadenopathy (HP:0100721)1.80815325

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.15381776
2ERN14.50147412
3FGFR44.36576542
4SIK14.07694925
5MAP4K13.70983200
6RIPK43.50963922
7MST1R3.19507441
8TAOK32.82301088
9ERBB42.55601858
10INSRR2.53588279
11FES2.16601411
12ACVR1B2.05465591
13BLK1.98685036
14MAP2K41.98416136
15FRK1.86787804
16IRAK41.85602096
17PKN21.83029037
18MAPK111.82454918
19TNK21.76776599
20TRIB31.69935184
21ZAP701.68476635
22TXK1.63494364
23PTK61.62358180
24GRK61.62098522
25MATK1.61935335
26KIT1.57739308
27PIK3CG1.56346115
28SYK1.52435309
29FLT31.50960010
30TESK21.49497754
31FGR1.47245699
32TYK21.43947860
33ABL21.40976044
34PRPF4B1.40701161
35LATS11.40458586
36JAK31.35855378
37BTK1.32124331
38STK38L1.31856621
39WNK41.31551730
40MAP3K71.28029745
41DAPK21.24052209
42WNK31.23311257
43NEK91.21027105
44TBK11.18888806
45MET1.18622856
46LYN1.17193222
47PRKAA21.17086575
48KDR1.16282430
49PINK11.14156896
50LCK1.13248622
51JAK21.11328917
52ITK1.09156603
53TAOK11.09029194
54HCK1.03922850
55MAP2K30.97826671
56MAP3K140.96550616
57EPHB10.96508835
58MAP3K30.96157111
59FGFR20.93957435
60OXSR10.91958836
61MAP3K110.91583655
62ERBB20.91067011
63SIK20.90399224
64MAP3K100.87467531
65PRKCZ0.87410192
66IKBKB0.86940364
67MAPK40.86602886
68MAPK150.80497140
69TEC0.80305631
70RIPK10.79059244
71MAPK120.78945829
72JAK10.78665434
73DYRK1B0.78502888
74CDC42BPA0.78259648
75IRAK30.78194926
76PRKACG0.76417953
77MAP2K60.75638433
78TIE10.74844734
79SGK30.73046739
80GSK3A0.72523754
81PTK20.71345291
82PRKAA10.71140474
83PIK3CA0.69603216
84CDK120.68276451
85CSK0.67697295
86CAMK2G0.67461537
87MAP2K20.67310676
88NLK0.66772756
89CDK60.65432445
90PDPK10.62951828
91PDK30.61362130
92PDK40.61362130
93SGK2230.61242908
94SGK4940.61242908
95EPHA40.58073367
96MAP2K10.57369588
97MARK30.56926514
98BMPR20.55947856
99IKBKE0.55879734
100LRRK20.55589759
101SGK20.54391712
102EPHA30.53425006
103TGFBR20.52861590
104TAOK20.52161100
105FYN0.52018849
106MAP3K20.51784395
107PBK0.51577757
108YES10.50855102
109PIM10.49842646
110PRKCQ0.48764991
111IRAK10.47434768
112CAMK1D0.45271745
113HIPK20.44593138
114MAP3K60.43739139
115MARK20.42837715
116MAPK70.42310441
117GRK10.41396143
118IGF1R0.40387230
119MAP3K10.39480519
120PRKCD0.38571179
121PDK10.36703772
122FGFR30.36417609
123RPS6KC10.35741469
124RPS6KL10.35741469
125MAP3K50.35436342
126SMG10.33652715
127NEK10.33382882
128MAP3K130.32765582
129KSR20.32762457
130RET0.32295293
131PRKCA0.32074357
132CDK190.31941767
133PDK20.30994354
134CSNK1G10.30956511
135MAPKAPK20.30585657
136PRKCG0.30555312
137RPS6KA60.30498221
138BMX0.30271003
139CDK40.30028499
140CSF1R0.29131225
141ICK0.28848393
142PRKG20.28405160
143CAMK40.26094745
144EGFR0.25432340
145EPHB20.24355421

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.21524293
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.43476399
3Nitrogen metabolism_Homo sapiens_hsa009103.30302626
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.16273552
5Arginine biosynthesis_Homo sapiens_hsa002202.92708149
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.71169844
7Tryptophan metabolism_Homo sapiens_hsa003802.70290512
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.62734939
9Fatty acid degradation_Homo sapiens_hsa000712.54235920
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.48754406
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.48066413
12Complement and coagulation cascades_Homo sapiens_hsa046102.47863564
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.36995159
14Butanoate metabolism_Homo sapiens_hsa006502.29149256
15Peroxisome_Homo sapiens_hsa041462.14373274
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.10548258
17Propanoate metabolism_Homo sapiens_hsa006402.02643739
18Histidine metabolism_Homo sapiens_hsa003401.91690590
19PPAR signaling pathway_Homo sapiens_hsa033201.90736488
20Chemical carcinogenesis_Homo sapiens_hsa052041.88648874
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.87286838
22Fatty acid metabolism_Homo sapiens_hsa012121.85226614
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.82665383
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82121467
25beta-Alanine metabolism_Homo sapiens_hsa004101.73645008
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.68403934
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.66126056
28Caffeine metabolism_Homo sapiens_hsa002321.63417504
29Retinol metabolism_Homo sapiens_hsa008301.62486465
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.61531544
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.61528858
32Bile secretion_Homo sapiens_hsa049761.61299331
33Sulfur metabolism_Homo sapiens_hsa009201.57206754
34Staphylococcus aureus infection_Homo sapiens_hsa051501.51481127
35Selenocompound metabolism_Homo sapiens_hsa004501.50859129
36Pyruvate metabolism_Homo sapiens_hsa006201.50398767
37Phenylalanine metabolism_Homo sapiens_hsa003601.48522898
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39059605
39Starch and sucrose metabolism_Homo sapiens_hsa005001.36840499
40Fat digestion and absorption_Homo sapiens_hsa049751.35043820
41Tyrosine metabolism_Homo sapiens_hsa003501.33431627
42Folate biosynthesis_Homo sapiens_hsa007901.32067276
43Fatty acid elongation_Homo sapiens_hsa000621.31677702
44Other glycan degradation_Homo sapiens_hsa005111.30060034
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.29720330
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.25559866
47Carbon metabolism_Homo sapiens_hsa012001.21043539
48Biosynthesis of amino acids_Homo sapiens_hsa012301.19538120
49Steroid biosynthesis_Homo sapiens_hsa001001.15540494
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13751684
51Vitamin digestion and absorption_Homo sapiens_hsa049771.12794457
52ABC transporters_Homo sapiens_hsa020101.12348519
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11482106
54Arginine and proline metabolism_Homo sapiens_hsa003301.06726940
55Maturity onset diabetes of the young_Homo sapiens_hsa049501.05099932
56Graft-versus-host disease_Homo sapiens_hsa053320.96658718
57Sulfur relay system_Homo sapiens_hsa041220.94524514
58Allograft rejection_Homo sapiens_hsa053300.92605322
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92256761
60Leishmaniasis_Homo sapiens_hsa051400.89993492
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87456884
62Asthma_Homo sapiens_hsa053100.84176568
63Autoimmune thyroid disease_Homo sapiens_hsa053200.83330331
64Glutathione metabolism_Homo sapiens_hsa004800.82802190
65Lysine degradation_Homo sapiens_hsa003100.82462410
66Vitamin B6 metabolism_Homo sapiens_hsa007500.80696861
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79669606
68Glycerolipid metabolism_Homo sapiens_hsa005610.78293486
69Pertussis_Homo sapiens_hsa051330.77257987
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68385062
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.65572265
72Pentose phosphate pathway_Homo sapiens_hsa000300.63243631
73One carbon pool by folate_Homo sapiens_hsa006700.62774008
74Type I diabetes mellitus_Homo sapiens_hsa049400.61476425
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59030588
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58780566
77Antigen processing and presentation_Homo sapiens_hsa046120.53123159
78Hematopoietic cell lineage_Homo sapiens_hsa046400.53073898
79Primary immunodeficiency_Homo sapiens_hsa053400.51395548
80Osteoclast differentiation_Homo sapiens_hsa043800.51330472
81Fatty acid biosynthesis_Homo sapiens_hsa000610.50604743
82Metabolic pathways_Homo sapiens_hsa011000.49041078
83Fructose and mannose metabolism_Homo sapiens_hsa000510.43079859
84Galactose metabolism_Homo sapiens_hsa000520.40184244
85Tuberculosis_Homo sapiens_hsa051520.35297770
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32829620
87Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31891339
88Prion diseases_Homo sapiens_hsa050200.26105941
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.25599703
90B cell receptor signaling pathway_Homo sapiens_hsa046620.25152865
91Linoleic acid metabolism_Homo sapiens_hsa005910.24643054
92Insulin resistance_Homo sapiens_hsa049310.19930053
93Sphingolipid metabolism_Homo sapiens_hsa006000.19296487
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.18889423
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.18446049
96Herpes simplex infection_Homo sapiens_hsa051680.17689316
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17369034
98Toll-like receptor signaling pathway_Homo sapiens_hsa046200.14903004
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.13353560
100Influenza A_Homo sapiens_hsa051640.13321774
101Renin-angiotensin system_Homo sapiens_hsa046140.07211726
102Glucagon signaling pathway_Homo sapiens_hsa049220.05308795
103Mineral absorption_Homo sapiens_hsa049780.04435119
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.01743560
105Systemic lupus erythematosus_Homo sapiens_hsa05322-0.2415254
106Lysosome_Homo sapiens_hsa04142-0.2345783
107Bladder cancer_Homo sapiens_hsa05219-0.2154700
108Ether lipid metabolism_Homo sapiens_hsa00565-0.1968131
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1778825
110Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1698755
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1687772
112Regulation of autophagy_Homo sapiens_hsa04140-0.1666441
113Hepatitis C_Homo sapiens_hsa05160-0.1447968
114Insulin signaling pathway_Homo sapiens_hsa04910-0.1360395
115African trypanosomiasis_Homo sapiens_hsa05143-0.1281398
116Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1234019
117Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1103801
118Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1080214
119Protein digestion and absorption_Homo sapiens_hsa04974-0.1038833
120Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0519924
121Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0487577
122AMPK signaling pathway_Homo sapiens_hsa04152-0.0128283
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0125405

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