CILP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cornea development in camera-type eye (GO:0061303)8.08533338
2skeletal muscle adaptation (GO:0043501)8.02118269
3negative regulation of stress fiber assembly (GO:0051497)6.54777045
4negative regulation of Rho protein signal transduction (GO:0035024)6.06568289
5myoblast migration (GO:0051451)5.97026889
6protein heterotrimerization (GO:0070208)5.90056385
7epithelial cell-cell adhesion (GO:0090136)5.82994144
8extracellular matrix assembly (GO:0085029)5.72943650
9peripheral nervous system axon ensheathment (GO:0032292)5.62580705
10myelination in peripheral nervous system (GO:0022011)5.62580705
11ribosomal small subunit biogenesis (GO:0042274)5.52985778
12heterochromatin organization (GO:0070828)5.42137010
13negative regulation of actin filament bundle assembly (GO:0032232)5.14489664
14neuronal ion channel clustering (GO:0045161)4.90146836
15regulation of posttranscriptional gene silencing (GO:0060147)4.84630946
16regulation of gene silencing by miRNA (GO:0060964)4.84630946
17regulation of gene silencing by RNA (GO:0060966)4.84630946
18keratan sulfate biosynthetic process (GO:0018146)4.64416724
19outer ear morphogenesis (GO:0042473)4.43770478
20striated muscle hypertrophy (GO:0014897)4.19023591
21regulation of mammary gland epithelial cell proliferation (GO:0033599)4.12123649
22regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.09606870
23collagen fibril organization (GO:0030199)3.99500281
24paraxial mesoderm development (GO:0048339)3.95042847
25keratan sulfate metabolic process (GO:0042339)3.80721978
26viral transcription (GO:0019083)3.80128901
27chromatin assembly (GO:0031497)3.78420009
28DNA unwinding involved in DNA replication (GO:0006268)3.72876894
29negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.69770285
30cochlea morphogenesis (GO:0090103)3.64734904
31positive regulation of p38MAPK cascade (GO:1900745)3.61657236
32extracellular fibril organization (GO:0043206)3.60604748
33skin morphogenesis (GO:0043589)3.60359637
34translational termination (GO:0006415)3.59128729
35convergent extension (GO:0060026)3.57925799
36proline biosynthetic process (GO:0006561)3.57755806
37endothelial cell morphogenesis (GO:0001886)3.57705128
38muscle hypertrophy (GO:0014896)3.56940747
39non-canonical Wnt signaling pathway (GO:0035567)3.55241256
40striated muscle adaptation (GO:0014888)3.53847552
41ribonucleoprotein complex biogenesis (GO:0022613)3.52192151
42protein complex localization (GO:0031503)3.48707812
43protein maturation by protein folding (GO:0022417)3.46331455
44bone trabecula formation (GO:0060346)3.45983153
45lung-associated mesenchyme development (GO:0060484)3.45474058
46positive regulation of SMAD protein import into nucleus (GO:0060391)3.44582282
47cellular response to cadmium ion (GO:0071276)3.42325059
48regulation of mitotic spindle organization (GO:0060236)3.40010554
49formation of translation preinitiation complex (GO:0001731)3.39701355
50regulation of mitochondrial depolarization (GO:0051900)3.38141751
51regulation of p38MAPK cascade (GO:1900744)3.31789292
52mitotic chromosome condensation (GO:0007076)3.31030599
53maturation of SSU-rRNA (GO:0030490)3.30370235
54translational elongation (GO:0006414)3.28706242
55peptidyl-arginine omega-N-methylation (GO:0035247)3.27293884
56regulation of cardioblast differentiation (GO:0051890)3.26410294
57nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.24942062
58ribosome biogenesis (GO:0042254)3.24125210
59ribosome assembly (GO:0042255)3.23552946
60muscle cell migration (GO:0014812)3.23064240
61negative regulation of cell-matrix adhesion (GO:0001953)3.22325294
62tooth mineralization (GO:0034505)3.18180728
63regulation of hair follicle development (GO:0051797)3.17912670
64histone arginine methylation (GO:0034969)3.16514483
65ribosomal small subunit assembly (GO:0000028)3.16341506
66regulation of SMAD protein import into nucleus (GO:0060390)3.13055663
67protein localization to chromosome, centromeric region (GO:0071459)3.11157716
68spliceosomal tri-snRNP complex assembly (GO:0000244)3.11092426
69protein retention in ER lumen (GO:0006621)3.10955571
70L-serine metabolic process (GO:0006563)3.10564911
71DNA strand elongation involved in DNA replication (GO:0006271)3.09000024
72DNA replication initiation (GO:0006270)3.04574252
73DNA strand elongation (GO:0022616)3.04386703
74fibril organization (GO:0097435)3.03897982
75plasma membrane repair (GO:0001778)3.00254842
76polarized epithelial cell differentiation (GO:0030859)2.97391394
77collagen metabolic process (GO:0032963)2.96837411
78ncRNA 3-end processing (GO:0043628)2.96336388
79pre-miRNA processing (GO:0031054)2.96116652
80SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.96004881
81negative regulation of mRNA processing (GO:0050686)2.95985197
82trophoblast giant cell differentiation (GO:0060707)2.95418672
83maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.94559906
84Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.94440530
85IMP biosynthetic process (GO:0006188)2.92846864
86deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.92832407
87negative regulation of RNA splicing (GO:0033119)2.92299340
88G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.90598091
89regulation of mitochondrial translation (GO:0070129)2.89091187
90growth hormone secretion (GO:0030252)2.88918152
91positive regulation of hair follicle development (GO:0051798)2.88380154
92positive regulation of hair cycle (GO:0042635)2.88380154
93anterior/posterior axis specification, embryo (GO:0008595)2.87663335
94rRNA transcription (GO:0009303)2.86642983
95cellular sodium ion homeostasis (GO:0006883)2.86374139
96muscle adaptation (GO:0043500)2.83659454
97cotranslational protein targeting to membrane (GO:0006613)2.83433918
98protein targeting to ER (GO:0045047)2.81920074
99cellular protein complex disassembly (GO:0043624)2.80987527
100regulation of hippo signaling (GO:0035330)2.79587227
101multicellular organismal macromolecule metabolic process (GO:0044259)2.79527412
102COPI coating of Golgi vesicle (GO:0048205)2.79252840
103Golgi transport vesicle coating (GO:0048200)2.79252840
104peptidyl-arginine methylation (GO:0018216)2.78678576
105peptidyl-arginine N-methylation (GO:0035246)2.78678576
106translational initiation (GO:0006413)2.78475508
107collagen catabolic process (GO:0030574)2.77921941
108mitotic nuclear envelope reassembly (GO:0007084)2.76814701
109nuclear envelope reassembly (GO:0031468)2.76814701
110cellular protein complex localization (GO:0034629)2.76448463
111regulation of telomere maintenance via telomerase (GO:0032210)2.76185379
112regulation of establishment of planar polarity (GO:0090175)2.76148167
113muscle filament sliding (GO:0030049)2.75827535
114actin-myosin filament sliding (GO:0033275)2.75827535
115viral life cycle (GO:0019058)2.75064507
116protein complex disassembly (GO:0043241)2.74777816
117regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.73552814
118telomere maintenance via semi-conservative replication (GO:0032201)2.72284970
119establishment of apical/basal cell polarity (GO:0035089)2.70469420
120regulation of spindle organization (GO:0090224)2.69764163
121negative regulation of mRNA metabolic process (GO:1903312)2.69665411
122adherens junction assembly (GO:0034333)2.69387282
123protein localization to kinetochore (GO:0034501)2.69216483
124establishment of protein localization to endoplasmic reticulum (GO:0072599)2.67508958
125complement activation, alternative pathway (GO:0006957)2.66630860
126regulation of chromatin binding (GO:0035561)2.65839204
127DNA replication-dependent nucleosome organization (GO:0034723)2.65280946
128DNA replication-dependent nucleosome assembly (GO:0006335)2.65280946
129mitotic sister chromatid segregation (GO:0000070)2.64987987
130pseudouridine synthesis (GO:0001522)2.62805742
131positive regulation of synapse maturation (GO:0090129)2.62705173
132regulation of striated muscle cell apoptotic process (GO:0010662)2.62682877
133apoptotic process involved in morphogenesis (GO:0060561)2.62131314
134rRNA processing (GO:0006364)2.61814097
135outflow tract septum morphogenesis (GO:0003148)2.61755489
136protein localization to endoplasmic reticulum (GO:0070972)2.61288642
137DNA strand renaturation (GO:0000733)2.61052802
138IMP metabolic process (GO:0046040)2.60682264
139nuclear pore organization (GO:0006999)2.59655293
140multicellular organismal metabolic process (GO:0044236)2.59519234
141nucleosome disassembly (GO:0006337)2.59452597
142protein-DNA complex disassembly (GO:0032986)2.59452597
143regulation of translational termination (GO:0006449)2.58164747
144negative regulation of cell fate specification (GO:0009996)2.57669152
145cranial nerve morphogenesis (GO:0021602)2.57658307
146DNA replication checkpoint (GO:0000076)2.56848642
147regulation of skeletal muscle contraction (GO:0014819)2.56653204
148glomerular basement membrane development (GO:0032836)2.53635229
149multicellular organismal catabolic process (GO:0044243)2.53447641
150kidney mesenchyme development (GO:0072074)2.51865311
151negative regulation of muscle hypertrophy (GO:0014741)2.51803926
152embryonic skeletal joint morphogenesis (GO:0060272)2.51057913
153chaperone-mediated protein transport (GO:0072321)2.50838179
154regulation of translational fidelity (GO:0006450)2.50300123
155macromolecular complex disassembly (GO:0032984)2.49957926
156positive regulation of adherens junction organization (GO:1903393)2.49829074
157cellular component biogenesis (GO:0044085)2.47373115
158positive regulation of neutrophil chemotaxis (GO:0090023)2.46546108
159positive regulation of neutrophil migration (GO:1902624)2.46546108
160sarcoplasmic reticulum calcium ion transport (GO:0070296)2.45743948
161facial nerve structural organization (GO:0021612)2.45411351
162barbed-end actin filament capping (GO:0051016)2.45276531
163nucleobase biosynthetic process (GO:0046112)2.45223247
164rRNA metabolic process (GO:0016072)2.43998426
165regulation of Rho protein signal transduction (GO:0035023)2.43834707
166chromosome condensation (GO:0030261)2.43788123
167negative regulation of Ras protein signal transduction (GO:0046580)2.43725302
168regulation of cell fate specification (GO:0042659)2.43122267
169generation of neurons (GO:0048699)2.41722883
170sulfur compound catabolic process (GO:0044273)2.41642832
171regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.41297796
172establishment of monopolar cell polarity (GO:0061162)2.41093686
173establishment or maintenance of monopolar cell polarity (GO:0061339)2.41093686
174regulation of stem cell maintenance (GO:2000036)2.40650939
175nuclear pore complex assembly (GO:0051292)2.39771979
176negative regulation of androgen receptor signaling pathway (GO:0060766)2.37686676
177positive regulation of cell junction assembly (GO:1901890)2.37471368
178positive regulation of focal adhesion assembly (GO:0051894)2.37471368
179planar cell polarity pathway involved in neural tube closure (GO:0090179)2.35615974
180negative regulation of small GTPase mediated signal transduction (GO:0051058)2.35046088
181piRNA metabolic process (GO:0034587)2.34355150
182regulation of meiosis I (GO:0060631)2.34288903
183ribosomal large subunit biogenesis (GO:0042273)2.33671867
184regulation of fibroblast migration (GO:0010762)2.32899854
185keratan sulfate catabolic process (GO:0042340)10.0219996

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.21171784
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.21171784
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.21171784
4E2F7_22180533_ChIP-Seq_HELA_Human4.00561973
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.30890541
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.29473933
7NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.15358448
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.14820171
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.12175456
10TP63_17297297_ChIP-ChIP_HaCaT_Human3.08454620
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.81360596
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.80152550
13POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.72857132
14ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.64703935
15SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.60452191
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.50843721
17STAT3_1855785_ChIP-Seq_MESCs_Mouse2.44587825
18TCF3_18692474_ChIP-Seq_MEFs_Mouse2.25282887
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.20341883
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.19318039
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.18712842
22ZFP281_18757296_ChIP-ChIP_E14_Mouse2.17629889
23SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.17560186
24ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.16481764
25NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.16044222
26NANOG_18555785_ChIP-Seq_MESCs_Mouse2.04358510
27CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.04151058
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.01513692
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.00432793
30ZNF263_19887448_ChIP-Seq_K562_Human1.98384997
31SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.96259510
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.96250628
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.92902042
34* LXR_22292898_ChIP-Seq_THP-1_Human1.91812838
35NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.90835152
36TCF3_18692474_ChIP-Seq_MESCs_Mouse1.89609501
37MYC_22102868_ChIP-Seq_BL_Human1.85334885
38DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.84707493
39VDR_21846776_ChIP-Seq_THP-1_Human1.80763680
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.79828522
41KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.77038725
42TET1_21451524_ChIP-Seq_MESCs_Mouse1.74410413
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.70324654
44MYC_19030024_ChIP-ChIP_MESCs_Mouse1.69421461
45SOX2_18692474_ChIP-Seq_MEFs_Mouse1.68209018
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.66923562
47SOX2_18555785_ChIP-Seq_MESCs_Mouse1.62204621
48CLOCK_20551151_ChIP-Seq_293T_Human1.62173192
49ESR1_21235772_ChIP-Seq_MCF-7_Human1.62078632
50HIF1A_21447827_ChIP-Seq_MCF-7_Human1.57949718
51TTF2_22483619_ChIP-Seq_HELA_Human1.57339813
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.56870181
53KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.56669550
54ETS1_20019798_ChIP-Seq_JURKAT_Human1.56604953
55HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.54943750
56TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54364419
57NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.52896175
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.52527346
59DCP1A_22483619_ChIP-Seq_HELA_Human1.52203951
60NELFA_20434984_ChIP-Seq_ESCs_Mouse1.51468197
61CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.51324922
62ESR1_15608294_ChIP-ChIP_MCF-7_Human1.51200657
63EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47395397
64P68_20966046_ChIP-Seq_HELA_Human1.45305484
65SOX2_18692474_ChIP-Seq_MESCs_Mouse1.44444152
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43571402
67RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.43307703
68ZFP281_27345836_Chip-Seq_ESCs_Mouse1.42953835
69NANOG_18692474_ChIP-Seq_MEFs_Mouse1.42781865
70SRY_22984422_ChIP-ChIP_TESTIS_Rat1.37768903
71CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.36380778
72MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.36161315
73GABP_19822575_ChIP-Seq_HepG2_Human1.34445181
74WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33932275
75XRN2_22483619_ChIP-Seq_HELA_Human1.33661721
76HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.32879705
77OCT4_18692474_ChIP-Seq_MEFs_Mouse1.31594041
78SA1_27219007_Chip-Seq_ERYTHROID_Human1.31161682
79MYC_18358816_ChIP-ChIP_MESCs_Mouse1.30719074
80CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.29449012
81ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.28631690
82CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28566563
83NANOG_18692474_ChIP-Seq_MESCs_Mouse1.28060332
84SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.27396883
85POU5F1_16518401_ChIP-PET_MESCs_Mouse1.26242134
86TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.25915038
87* FOXP1_21924763_ChIP-Seq_HESCs_Human1.25014035
88NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.24423373
89PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.23879346
90ATF3_27146783_Chip-Seq_COLON_Human1.22761339
91TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.22270929
92YY1_21170310_ChIP-Seq_MESCs_Mouse1.21986735
93KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.21700234
94CTCF_27219007_Chip-Seq_ERYTHROID_Human1.20090424
95CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19267156
96UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18838810
97TP63_19390658_ChIP-ChIP_HaCaT_Human1.18527957
98THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18426168
99KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18373857
100POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.15958913
101CTCF_18555785_ChIP-Seq_MESCs_Mouse1.15098847
102DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14530502
103ERG_21242973_ChIP-ChIP_JURKAT_Human1.14410898
104EGR1_19032775_ChIP-ChIP_M12_Human1.12575880
105KDM5A_27292631_Chip-Seq_BREAST_Human1.12001429
106NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.11846502
107PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.11583762
108SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.10298975
109TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09276623
110ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.08917159
111KDM2B_26808549_Chip-Seq_DND41_Human1.08020977
112AR_21909140_ChIP-Seq_LNCAP_Human1.07973126
113STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07663346
114TP53_20018659_ChIP-ChIP_R1E_Mouse1.07603614
115ELK3_25401928_ChIP-Seq_HUVEC_Human1.07476385
116NANOG_16153702_ChIP-ChIP_HESCs_Human1.06414555
117E2F4_17652178_ChIP-ChIP_JURKAT_Human1.04662697
118NANOG_21062744_ChIP-ChIP_HESCs_Human1.04492120
119E2F1_21310950_ChIP-Seq_MCF-7_Human1.03998604
120ESR2_21235772_ChIP-Seq_MCF-7_Human1.03840243
121CREB1_26743006_Chip-Seq_LNCaP_Human1.02263477
122KDM2B_26808549_Chip-Seq_K562_Human1.01925891
123CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.00514553
124CTCF_21964334_Chip-Seq_Bcells_Human1.00253500
125CTCF_27219007_Chip-Seq_Bcells_Human1.00157294
126* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00032376
127POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.99767520
128SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99391414
129RARA_24833708_ChIP-Seq_LIVER_Mouse0.99047172
130PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98890480
131TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98840183
132KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.98447713
133POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98235749
134CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97910113
135RACK7_27058665_Chip-Seq_MCF-7_Human0.97524311
136KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97369650
137SOX2_16153702_ChIP-ChIP_HESCs_Human0.97098558
138EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97054158
139TP53_22127205_ChIP-Seq_IMR90_Human0.95322162
140E2F1_18555785_ChIP-Seq_MESCs_Mouse0.93210740
141MYCN_18555785_ChIP-Seq_MESCs_Mouse0.93189776
142TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91520562
143P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91021224
144UBF1/2_26484160_Chip-Seq_HMECs_Human0.89980512
145ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.87652273
146SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.87287116
147SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.86458846
148KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85210074
149FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.83864145
150POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83749860
151YY1_22570637_ChIP-Seq_MALME-3M_Human0.83078542

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology7.21787049
2MP0005257_abnormal_intraocular_pressure6.88725700
3MP0005275_abnormal_skin_tensile6.33536495
4MP0008438_abnormal_cutaneous_collagen5.23886267
5MP0000751_myopathy3.13953979
6MP0000678_abnormal_parathyroid_gland2.88023642
7MP0002108_abnormal_muscle_morphology2.79394738
8MP0005508_abnormal_skeleton_morphology2.27601418
9MP0000049_abnormal_middle_ear2.18578458
10MP0010234_abnormal_vibrissa_follicle2.13401689
11MP0003941_abnormal_skin_development2.09460258
12MP0002877_abnormal_melanocyte_morpholog1.99595941
13MP0000566_synostosis1.99381313
14MP0001188_hyperpigmentation1.96042369
15MP0004272_abnormal_basement_membrane1.93536765
16MP0003705_abnormal_hypodermis_morpholog1.93317649
17MP0000747_muscle_weakness1.92339087
18MP0005076_abnormal_cell_differentiation1.90613194
19MP0000750_abnormal_muscle_regeneration1.89810367
20MP0003646_muscle_fatigue1.80440138
21MP0005623_abnormal_meninges_morphology1.77744776
22MP0002254_reproductive_system_inflammat1.77458654
23MP0004145_abnormal_muscle_electrophysio1.73547295
24MP0001958_emphysema1.71940993
25MP0000749_muscle_degeneration1.68971584
26MP0009053_abnormal_anal_canal1.66334383
27MP0005369_muscle_phenotype1.64764905
28MP0003942_abnormal_urinary_system1.60557222
29MP0004133_heterotaxia1.56616080
30MP0003937_abnormal_limbs/digits/tail_de1.56259139
31MP0002163_abnormal_gland_morphology1.55396238
32MP0001346_abnormal_lacrimal_gland1.55076788
33MP0003119_abnormal_digestive_system1.53896129
34MP0000579_abnormal_nail_morphology1.53021721
35MP0008007_abnormal_cellular_replicative1.47911484
36MP0005451_abnormal_body_composition1.46417492
37MP0002822_catalepsy1.44355787
38MP0003283_abnormal_digestive_organ1.42791657
39MP0002106_abnormal_muscle_physiology1.40995986
40MP0004084_abnormal_cardiac_muscle1.36017656
41MP0000537_abnormal_urethra_morphology1.35394926
42MP0005409_darkened_coat_color1.34858842
43MP0004087_abnormal_muscle_fiber1.32139418
44MP0002060_abnormal_skin_morphology1.31198649
45MP0010352_gastrointestinal_tract_polyps1.28942430
46MP0005330_cardiomyopathy1.26259549
47MP0009384_cardiac_valve_regurgitation1.23717006
48MP0000759_abnormal_skeletal_muscle1.23700025
49MP0000762_abnormal_tongue_morphology1.22627456
50MP0002116_abnormal_craniofacial_bone1.20837862
51MP0004957_abnormal_blastocyst_morpholog1.19950861
52MP0002269_muscular_atrophy1.19244815
53MP0006054_spinal_hemorrhage1.18590957
54MP0000733_abnormal_muscle_development1.17129493
55MP0001299_abnormal_eye_distance/1.15706872
56MP0003984_embryonic_growth_retardation1.13597210
57MP0004036_abnormal_muscle_relaxation1.13160467
58MP0002092_abnormal_eye_morphology1.10663046
59MP0003315_abnormal_perineum_morphology1.09903610
60MP0002080_prenatal_lethality1.09575254
61MP0002088_abnormal_embryonic_growth/wei1.06611474
62MP0005058_abnormal_lysosome_morphology1.04501155
63MP0005023_abnormal_wound_healing1.04321063
64MP0003938_abnormal_ear_development1.04035305
65MP0003861_abnormal_nervous_system1.03331337
66MP0003123_paternal_imprinting1.02676725
67MP0002837_dystrophic_cardiac_calcinosis1.02512644
68MP0002089_abnormal_postnatal_growth/wei1.02266065
69MP0001542_abnormal_bone_strength1.01980879
70MP0000467_abnormal_esophagus_morphology1.00956946
71MP0003279_aneurysm1.00394987
72MP0003111_abnormal_nucleus_morphology0.99823775
73MP0003453_abnormal_keratinocyte_physiol0.99468449
74MP0000432_abnormal_head_morphology0.96952845
75MP0005390_skeleton_phenotype0.96784066
76MP0002177_abnormal_outer_ear0.96551590
77MP0000462_abnormal_digestive_system0.96548304
78MP0002796_impaired_skin_barrier0.96426465
79MP0008058_abnormal_DNA_repair0.95472117
80MP0002234_abnormal_pharynx_morphology0.95032218
81MP0000003_abnormal_adipose_tissue0.93266962
82MP0003385_abnormal_body_wall0.93256249
83MP0010307_abnormal_tumor_latency0.92925778
84MP0001661_extended_life_span0.92220393
85MP0000534_abnormal_ureter_morphology0.92037810
86MP0002249_abnormal_larynx_morphology0.89298850
87MP0002111_abnormal_tail_morphology0.88816651
88MP0010030_abnormal_orbit_morphology0.88452942
89MP0004233_abnormal_muscle_weight0.87301322
90MP0002332_abnormal_exercise_endurance0.85009544
91MP0008260_abnormal_autophagy0.84768332
92MP0004197_abnormal_fetal_growth/weight/0.84372982
93MP0009703_decreased_birth_body0.84341219
94MP0003566_abnormal_cell_adhesion0.83930994
95MP0005197_abnormal_uvea_morphology0.83765674
96MP0003115_abnormal_respiratory_system0.82988718
97MP0002933_joint_inflammation0.82876971
98MP0002084_abnormal_developmental_patter0.81625379
99MP0000313_abnormal_cell_death0.81611940
100MP0001730_embryonic_growth_arrest0.81488256
101MP0006292_abnormal_olfactory_placode0.81213357
102MP0010094_abnormal_chromosome_stability0.80872895
103MP0003077_abnormal_cell_cycle0.79673115
104MP0003567_abnormal_fetal_cardiomyocyte0.78480785
105MP0001293_anophthalmia0.78032702
106MP0000350_abnormal_cell_proliferation0.77626066
107MP0000163_abnormal_cartilage_morphology0.77225066
108MP0003303_peritoneal_inflammation0.76927598
109MP0004185_abnormal_adipocyte_glucose0.76802427
110MP0003693_abnormal_embryo_hatching0.76542672
111MP0002085_abnormal_embryonic_tissue0.76218987
112MP0000428_abnormal_craniofacial_morphol0.75456731
113MP0003828_pulmonary_edema0.74918451
114MP0005501_abnormal_skin_physiology0.74726046
115MP0003755_abnormal_palate_morphology0.74397826
116MP0002896_abnormal_bone_mineralization0.73953680
117MP0009250_abnormal_appendicular_skeleto0.72646289
118MP0004858_abnormal_nervous_system0.72631986
119MP0010630_abnormal_cardiac_muscle0.71464075
120MP0004134_abnormal_chest_morphology0.71239274
121MP0002697_abnormal_eye_size0.69976851
122MP0001849_ear_inflammation0.69643453
123MP0002114_abnormal_axial_skeleton0.68513298
124MP0005620_abnormal_muscle_contractility0.68396463
125MP0004484_altered_response_of0.67729675
126MP0002115_abnormal_skeleton_extremities0.67271796
127MP0002233_abnormal_nose_morphology0.66174550
128MP0002932_abnormal_joint_morphology0.66009807
129MP0005165_increased_susceptibility_to0.65955723
130MP0001672_abnormal_embryogenesis/_devel0.65417947
131MP0005380_embryogenesis_phenotype0.65417947
132MP0001348_abnormal_lacrimal_gland0.64624018
133MP0005187_abnormal_penis_morphology0.64411700
134MP0001697_abnormal_embryo_size0.64183571
135MP0008932_abnormal_embryonic_tissue0.64011635
136MP0002086_abnormal_extraembryonic_tissu0.63531442
137MP0003935_abnormal_craniofacial_develop0.63262965
138MP0002127_abnormal_cardiovascular_syste0.62446053
139MP0004215_abnormal_myocardial_fiber0.62142271
140MP0002295_abnormal_pulmonary_circulatio0.61882441
141MP0009672_abnormal_birth_weight0.61786641
142MP0002282_abnormal_trachea_morphology0.61185546
143MP0001915_intracranial_hemorrhage0.61095581

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.00809030
2Increased connective tissue (HP:0009025)5.85473385
3Flat cornea (HP:0007720)5.48295552
4Ankle contracture (HP:0006466)5.36054496
5Muscle fiber splitting (HP:0003555)5.27072149
6Type 1 muscle fiber predominance (HP:0003803)5.12130506
7Premature rupture of membranes (HP:0001788)4.79375499
8Soft skin (HP:0000977)4.00064219
9Broad distal phalanx of finger (HP:0009836)3.98318235
10Wrist flexion contracture (HP:0001239)3.85985623
11Shallow orbits (HP:0000586)3.40628296
12Spinal rigidity (HP:0003306)3.40284090
13Broad metatarsal (HP:0001783)3.33612493
14Round ear (HP:0100830)3.29167778
15Breech presentation (HP:0001623)3.27601799
16Muscle fiber inclusion bodies (HP:0100299)3.25121011
17Slender build (HP:0001533)3.24825558
18Ulnar bowing (HP:0003031)3.21598075
19Aplasia/Hypoplasia of the sacrum (HP:0008517)3.18785753
20Rectal prolapse (HP:0002035)3.18762006
21Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.15964435
22Increased variability in muscle fiber diameter (HP:0003557)3.13366261
23Hyporeflexia of lower limbs (HP:0002600)3.09774111
24Bowed forearm bones (HP:0003956)3.06833047
25Bowing of the arm (HP:0006488)3.06833047
26Duplicated collecting system (HP:0000081)3.01821958
27Bladder diverticulum (HP:0000015)2.95329509
28Abnormality of skeletal muscle fiber size (HP:0012084)2.94803565
29Abnormality of the aortic arch (HP:0012303)2.93174522
30Follicular hyperkeratosis (HP:0007502)2.90285535
31Exercise-induced muscle cramps (HP:0003710)2.88455138
32Mildly elevated creatine phosphokinase (HP:0008180)2.88080699
33Neonatal short-limb short stature (HP:0008921)2.87951309
34Bronchomalacia (HP:0002780)2.87564479
35Genu recurvatum (HP:0002816)2.86625791
36Abnormality of dentin (HP:0010299)2.80705621
37Distal lower limb muscle weakness (HP:0009053)2.78885291
38Testicular atrophy (HP:0000029)2.78353882
39Biconcave vertebral bodies (HP:0004586)2.71675855
40Radial bowing (HP:0002986)2.71286478
41Hyperacusis (HP:0010780)2.70692413
42Nemaline bodies (HP:0003798)2.68652363
43Exercise-induced myalgia (HP:0003738)2.64488815
44Cerebral aneurysm (HP:0004944)2.61530670
45Difficulty climbing stairs (HP:0003551)2.56366583
46Short nail (HP:0001799)2.56280955
47Achilles tendon contracture (HP:0001771)2.54678391
48Truncus arteriosus (HP:0001660)2.54129013
49Wormian bones (HP:0002645)2.53218584
50Limb-girdle muscle weakness (HP:0003325)2.52136920
51Difficulty running (HP:0009046)2.51735359
52Abnormal number of incisors (HP:0011064)2.50136250
53Calcaneovalgus deformity (HP:0001848)2.48143644
54Atrophic scars (HP:0001075)2.47358423
55Pseudobulbar signs (HP:0002200)2.47324159
56Premature skin wrinkling (HP:0100678)2.41087423
57Spinal cord compression (HP:0002176)2.40017393
58Progressive muscle weakness (HP:0003323)2.39713142
59Deviation of the hallux (HP:0010051)2.38369109
60Deformed tarsal bones (HP:0008119)2.36045415
61Abnormality of the renal collecting system (HP:0004742)2.34588893
62Microretrognathia (HP:0000308)2.34139047
63Broad hallux (HP:0010055)2.33201558
64Ulnar deviation of the wrist (HP:0003049)2.32673068
65Abnormal delivery (HP:0001787)2.31662374
66Hallux valgus (HP:0001822)2.29606379
67Mitral valve prolapse (HP:0001634)2.29457767
68Hyperextensible skin (HP:0000974)2.28085823
69Areflexia of lower limbs (HP:0002522)2.27150784
70Breast hypoplasia (HP:0003187)2.25154205
71Mild short stature (HP:0003502)2.23414798
72Vertebral compression fractures (HP:0002953)2.22807942
73Abnormality of the Achilles tendon (HP:0005109)2.19871519
74Humeroradial synostosis (HP:0003041)2.18587609
75Synostosis involving the elbow (HP:0003938)2.18587609
76Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.18385227
77Muscle hypertrophy of the lower extremities (HP:0008968)2.17690811
78Insomnia (HP:0100785)2.17080252
79Transposition of the great arteries (HP:0001669)2.14653750
80Abnormal connection of the cardiac segments (HP:0011545)2.14653750
81Abnormal ventriculo-arterial connection (HP:0011563)2.14653750
82Calf muscle hypertrophy (HP:0008981)2.13887495
83Patellar dislocation (HP:0002999)2.13575623
84Joint laxity (HP:0001388)2.11711104
85Shoulder girdle muscle weakness (HP:0003547)2.10651274
86Ureteral duplication (HP:0000073)2.10122863
87Cervical subluxation (HP:0003308)2.07064047
88EMG: myopathic abnormalities (HP:0003458)2.05906188
89Broad toe (HP:0001837)2.05603635
90Syringomyelia (HP:0003396)2.04563318
91Spinal cord lesions (HP:0100561)2.04563318
92Broad phalanges of the hand (HP:0009768)2.04461260
93Congenital malformation of the right heart (HP:0011723)2.04454516
94Double outlet right ventricle (HP:0001719)2.04454516
95Abnormality of the calcaneus (HP:0008364)2.04074391
96Fragile skin (HP:0001030)2.03920560
97Proximal amyotrophy (HP:0007126)2.02421157
98Short hallux (HP:0010109)2.01708594
99Abnormality of cells of the erythroid lineage (HP:0012130)2.00415871
100Pulmonary artery stenosis (HP:0004415)2.00230545
101Long palpebral fissure (HP:0000637)2.00201766
102Hypoplastic ischia (HP:0003175)2.00113705
103Carpal synostosis (HP:0009702)1.99532353
104Slender long bone (HP:0003100)1.98284395
105Myopathic facies (HP:0002058)1.97938520
106Dilatation of the ascending aorta (HP:0005111)1.97826454
107Abnormality of the fetal cardiovascular system (HP:0010948)1.97806450
108Abnormal umbilical cord blood vessels (HP:0011403)1.97806450
109Single umbilical artery (HP:0001195)1.97806450
110Aplasia/Hypoplasia of the hallux (HP:0008362)1.97796232
111Distal arthrogryposis (HP:0005684)1.97682818
112Thin ribs (HP:0000883)1.97581154
113Wide anterior fontanel (HP:0000260)1.97140431
114Turricephaly (HP:0000262)1.96629456
115Ependymoma (HP:0002888)1.95961513
116Pelvic girdle muscle weakness (HP:0003749)1.95529127
117Rib fusion (HP:0000902)1.95406173
118Striae distensae (HP:0001065)1.95231995
119Carpal bone hypoplasia (HP:0001498)1.94588814
120Unilateral renal agenesis (HP:0000122)1.94376503
121Abnormality of the calf musculature (HP:0001430)1.93808482
122Abnormal number of erythroid precursors (HP:0012131)1.93038254
123Broad finger (HP:0001500)1.92889763
124Abnormality of the labia minora (HP:0012880)1.91927058
125Abnormality of the humeroradial joint (HP:0100744)1.90750245
126Upper limb amyotrophy (HP:0009129)1.89566980
127Distal upper limb amyotrophy (HP:0007149)1.89566980
128Blue sclerae (HP:0000592)1.88922760
129Birth length less than 3rd percentile (HP:0003561)1.88869106
130Complement deficiency (HP:0004431)1.88600381
131Atresia of the external auditory canal (HP:0000413)1.88431783
132Partial duplication of thumb phalanx (HP:0009944)1.88005510
133Abnormality of the umbilical cord (HP:0010881)1.87821485
134Hip contracture (HP:0003273)1.87774476
135Selective tooth agenesis (HP:0001592)1.87765232
136Patent foramen ovale (HP:0001655)1.86219262
137Small epiphyses (HP:0010585)1.85638854
138EMG: neuropathic changes (HP:0003445)1.85465859
139Aplasia/Hypoplasia of the patella (HP:0006498)1.84036511
140Aortic dissection (HP:0002647)1.83025102
141Myotonia (HP:0002486)1.82965329
142Broad long bones (HP:0005622)1.80996833
143Preauricular skin tag (HP:0000384)1.80859606
144Abnormality of the middle phalanges of the toes (HP:0010183)1.77996782
145Abnormality of the musculature of the pelvis (HP:0001469)1.77430123
146Abnormality of the hip-girdle musculature (HP:0001445)1.77430123
147Fibular aplasia (HP:0002990)1.77278404
148Missing ribs (HP:0000921)1.77103639
149Broad phalanx (HP:0006009)1.76570033
150Overriding aorta (HP:0002623)1.76222821
151Adducted thumb (HP:0001181)1.76193924
152Hand muscle atrophy (HP:0009130)1.75494944
153Abnormality of the distal phalanx of the thumb (HP:0009617)1.75070636
154Distal lower limb amyotrophy (HP:0008944)1.74297552
155High anterior hairline (HP:0009890)1.73308186
156Facial cleft (HP:0002006)1.73052311
157Trismus (HP:0000211)1.72719821
158Arnold-Chiari malformation (HP:0002308)1.72120565
159Choanal stenosis (HP:0000452)1.71686609
160Partial duplication of the phalanx of hand (HP:0009999)1.71294653
161Sudden death (HP:0001699)1.70835449
162Venous insufficiency (HP:0005293)1.70735875
163Broad thumb (HP:0011304)1.70367354
164Generalized amyotrophy (HP:0003700)1.69526533
165Abnormality of the distal phalanges of the toes (HP:0010182)1.69465336
166Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.69263024
167Vaginal fistula (HP:0004320)1.69239134
168Squamous cell carcinoma (HP:0002860)1.69147447
169Spastic diplegia (HP:0001264)1.69120282
170Ragged-red muscle fibers (HP:0003200)1.69119549
171Venous abnormality (HP:0002624)1.68503325
172Ventricular tachycardia (HP:0004756)1.68475620
173Abnormality of the phalanges of the hallux (HP:0010057)1.68188007
17411 pairs of ribs (HP:0000878)1.66862752
175Bell-shaped thorax (HP:0001591)1.66292773
176Renal duplication (HP:0000075)1.66100179

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG15.09055941
2EPHA23.82975279
3BUB13.68903593
4TSSK63.53584502
5TTN3.43961348
6DDR23.23291893
7VRK23.04389964
8MARK12.85822814
9OBSCN2.63116758
10PDGFRA2.34460184
11CDK122.32530717
12TAF12.25385969
13LATS22.16838437
14NEK11.99289287
15RIPK11.93151761
16PHKG21.92603745
17PHKG11.92603745
18PKN21.90022673
19AKT31.87256273
20WEE11.77790937
21RPS6KB21.77778515
22IRAK31.76129667
23PNCK1.67876183
24MAP3K91.67167826
25MAPKAPK31.62296314
26PDK31.57763978
27PDK41.57763978
28SIK11.56677843
29PBK1.56314949
30TRIB31.35780595
31MAP3K61.27187831
32TTK1.26809563
33ERBB41.24550187
34CDC71.24306884
35DYRK21.22755819
36NME11.22603821
37PDK21.21758651
38CAMK1D1.19406146
39ALK1.18549257
40SRPK11.10612780
41STK41.10603106
42NEK21.09933343
43MAP3K31.09861894
44KSR21.04073984
45PRPF4B1.03816731
46CDK41.01842797
47PAK40.99283734
48ARAF0.98662132
49PLK10.98049577
50PTK20.96973872
51CAMK1G0.96470879
52FGFR40.96087829
53TESK10.95791300
54LATS10.94331805
55BRD40.94330449
56TESK20.94317836
57MTOR0.93972392
58BCKDK0.93840018
59ACVR1B0.91635754
60STK38L0.89798237
61TAOK10.88268393
62PLK30.86776345
63ZAK0.86633468
64ERBB30.84553378
65AURKA0.84232422
66MET0.83745339
67LIMK10.79250903
68FGFR10.78739827
69SIK20.76941612
70CDK90.75419399
71STK160.75159722
72LRRK20.72019963
73FER0.71154384
74CDK70.70646861
75PRKCI0.69599905
76ATR0.68788290
77PAK20.68728446
78MAP3K80.68655831
79AKT20.67317605
80CHEK10.67290821
81KDR0.67172710
82BRSK10.66142491
83EPHB20.66088756
84VRK10.65517397
85ABL20.64870231
86BRAF0.63390728
87PDGFRB0.62297816
88MAP2K30.62089621
89RPS6KA20.61898897
90MUSK0.60769445
91CDK80.60269807
92DYRK30.60262860
93CSK0.58954143
94NTRK10.58236574
95MAP3K20.57867839
96DAPK30.56999452
97PINK10.56490083
98ERN10.56030993
99NME20.55902820
100LMTK20.55867661
101CSNK1E0.55158688
102CDK190.54721430
103CHEK20.53809125
104GSK3A0.53288601
105TAOK20.53271975
106CSNK1D0.50727886
107MAP3K70.48919287
108FLT30.48160096
109CDK20.47408667
110PAK60.46891448
111CDK11A0.46610673
112AURKB0.45584563
113DAPK10.45067345
114RPS6KL10.43623987
115RPS6KC10.43623987
116PASK0.41792226
117MAP3K10.41409722
118TYRO30.40506024
119PRKG20.39980204
120PAK10.39891690
121CSNK1A1L0.39542147
122CDK150.39224942
123BMX0.38880306
124MAPK120.38654534
125MAPK150.38380468
126ICK0.38317790
127PIM20.38289253
128RPS6KA60.38040880
129DMPK0.37959908
130MAPK90.37469143
131MAPKAPK50.37286457
132STK240.37270635
133NTRK20.36627040
134EEF2K0.35703008
135STK380.35647055
136PLK40.33333697
137PAK30.33313371
138MST1R0.32456288
139MAP3K100.32267231
140EPHA30.32148557
141CDK10.30961025
142STK110.30349230
143ILK0.29230968
144MAPK40.28640699
145PRKD30.28415152
146MAPK80.28102668
147TLK10.25359058
148STK30.25283891

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.29411070
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.82827083
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.66900067
4Prion diseases_Homo sapiens_hsa050202.45547959
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.38633797
6Ribosome_Homo sapiens_hsa030102.35982540
7Sulfur relay system_Homo sapiens_hsa041222.33561401
8Focal adhesion_Homo sapiens_hsa045102.27498445
9Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.27400867
10Protein digestion and absorption_Homo sapiens_hsa049742.20721633
11RNA transport_Homo sapiens_hsa030132.12925537
12Basal cell carcinoma_Homo sapiens_hsa052172.12629685
13Dilated cardiomyopathy_Homo sapiens_hsa054142.09359652
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.02335238
15Mismatch repair_Homo sapiens_hsa034301.99819984
16Hippo signaling pathway_Homo sapiens_hsa043901.92233024
17Spliceosome_Homo sapiens_hsa030401.84357166
18DNA replication_Homo sapiens_hsa030301.81588605
19Malaria_Homo sapiens_hsa051441.80920536
20p53 signaling pathway_Homo sapiens_hsa041151.79418125
21Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.76606798
22Cardiac muscle contraction_Homo sapiens_hsa042601.71675238
23Hedgehog signaling pathway_Homo sapiens_hsa043401.71114185
24TGF-beta signaling pathway_Homo sapiens_hsa043501.68034083
25Cell cycle_Homo sapiens_hsa041101.63147785
26RNA polymerase_Homo sapiens_hsa030201.62964382
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.57459766
28Fructose and mannose metabolism_Homo sapiens_hsa000511.52636283
29Galactose metabolism_Homo sapiens_hsa000521.52572693
30Folate biosynthesis_Homo sapiens_hsa007901.52160403
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.49970093
32Selenocompound metabolism_Homo sapiens_hsa004501.38465917
33Amoebiasis_Homo sapiens_hsa051461.38254476
34Systemic lupus erythematosus_Homo sapiens_hsa053221.37938904
35Small cell lung cancer_Homo sapiens_hsa052221.37438518
36Pentose phosphate pathway_Homo sapiens_hsa000301.36335026
37MicroRNAs in cancer_Homo sapiens_hsa052061.35248150
38Tight junction_Homo sapiens_hsa045301.33806725
39Nucleotide excision repair_Homo sapiens_hsa034201.31024982
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.30623024
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29332831
42Thyroid cancer_Homo sapiens_hsa052161.25464153
43PI3K-Akt signaling pathway_Homo sapiens_hsa041511.23859455
44Other glycan degradation_Homo sapiens_hsa005111.20247369
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19000346
46Bladder cancer_Homo sapiens_hsa052191.16908914
47Chronic myeloid leukemia_Homo sapiens_hsa052201.16745658
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.16350349
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.16286832
50Oocyte meiosis_Homo sapiens_hsa041141.14678704
51Proteoglycans in cancer_Homo sapiens_hsa052051.12998640
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12924217
53Wnt signaling pathway_Homo sapiens_hsa043101.10833797
54One carbon pool by folate_Homo sapiens_hsa006701.09740544
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97965757
56Proteasome_Homo sapiens_hsa030500.96521372
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96151985
58HTLV-I infection_Homo sapiens_hsa051660.95600272
59Lysine degradation_Homo sapiens_hsa003100.95375280
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95364481
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.94446508
62Estrogen signaling pathway_Homo sapiens_hsa049150.93378605
63N-Glycan biosynthesis_Homo sapiens_hsa005100.92335830
64Pathways in cancer_Homo sapiens_hsa052000.90308721
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.89244584
66Vitamin B6 metabolism_Homo sapiens_hsa007500.87541388
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85115104
68MAPK signaling pathway_Homo sapiens_hsa040100.84827688
69Base excision repair_Homo sapiens_hsa034100.83148783
70Viral carcinogenesis_Homo sapiens_hsa052030.82557284
71Fanconi anemia pathway_Homo sapiens_hsa034600.82339712
72mRNA surveillance pathway_Homo sapiens_hsa030150.82227573
73Viral myocarditis_Homo sapiens_hsa054160.81898989
74Huntingtons disease_Homo sapiens_hsa050160.81378774
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80405405
76mTOR signaling pathway_Homo sapiens_hsa041500.80321916
77Axon guidance_Homo sapiens_hsa043600.78569714
78Adherens junction_Homo sapiens_hsa045200.78460146
79Melanoma_Homo sapiens_hsa052180.77557171
80Melanogenesis_Homo sapiens_hsa049160.77294309
81Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.76609086
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.76479916
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76424845
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76262027
85Pyrimidine metabolism_Homo sapiens_hsa002400.72512838
86Epstein-Barr virus infection_Homo sapiens_hsa051690.71658840
87Insulin resistance_Homo sapiens_hsa049310.69598665
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69506412
89Vibrio cholerae infection_Homo sapiens_hsa051100.68500478
90Homologous recombination_Homo sapiens_hsa034400.67120627
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66232986
92Endometrial cancer_Homo sapiens_hsa052130.65932649
93Acute myeloid leukemia_Homo sapiens_hsa052210.64729774
94Renal cell carcinoma_Homo sapiens_hsa052110.64636479
95Parkinsons disease_Homo sapiens_hsa050120.64584298
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64477414
97Colorectal cancer_Homo sapiens_hsa052100.64203687
98Arginine and proline metabolism_Homo sapiens_hsa003300.62464808
99GnRH signaling pathway_Homo sapiens_hsa049120.61322249
100Insulin signaling pathway_Homo sapiens_hsa049100.61268061
101HIF-1 signaling pathway_Homo sapiens_hsa040660.61223244
102Oxytocin signaling pathway_Homo sapiens_hsa049210.61161656
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61089098
104Pancreatic cancer_Homo sapiens_hsa052120.60928196
105Notch signaling pathway_Homo sapiens_hsa043300.60458576
106Prostate cancer_Homo sapiens_hsa052150.56423411
107Biosynthesis of amino acids_Homo sapiens_hsa012300.55697421
108Sphingolipid metabolism_Homo sapiens_hsa006000.55007515
109Non-small cell lung cancer_Homo sapiens_hsa052230.53455253
110FoxO signaling pathway_Homo sapiens_hsa040680.52761039
111Dorso-ventral axis formation_Homo sapiens_hsa043200.52015147
112AMPK signaling pathway_Homo sapiens_hsa041520.51543409
113Fatty acid elongation_Homo sapiens_hsa000620.50025104
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49866583
115Glucagon signaling pathway_Homo sapiens_hsa049220.48451014
116Alzheimers disease_Homo sapiens_hsa050100.48152869
117Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48077513
118Alcoholism_Homo sapiens_hsa050340.47984555
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47946313
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.47083190
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46925014
122VEGF signaling pathway_Homo sapiens_hsa043700.46498361
123Lysosome_Homo sapiens_hsa041420.45079572
124Rap1 signaling pathway_Homo sapiens_hsa040150.44930464
125Purine metabolism_Homo sapiens_hsa002300.44560943
126Gap junction_Homo sapiens_hsa045400.44085521
127Type II diabetes mellitus_Homo sapiens_hsa049300.42481452
128Phenylalanine metabolism_Homo sapiens_hsa003600.41156971
129Basal transcription factors_Homo sapiens_hsa030220.40835398
130Glioma_Homo sapiens_hsa052140.40119668
131RNA degradation_Homo sapiens_hsa030180.38003775
132Carbon metabolism_Homo sapiens_hsa012000.37557464
133Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36191966
134Circadian rhythm_Homo sapiens_hsa047100.35303298
135Toxoplasmosis_Homo sapiens_hsa051450.34480399
136Oxidative phosphorylation_Homo sapiens_hsa001900.34458893
137ErbB signaling pathway_Homo sapiens_hsa040120.34037677

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