CINP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is reported to be a component of the DNA replication complex as well as a genome-maintenance protein. It may interact with proteins important for replication initiation and has been shown to bind chromatin at the G1 phase of the cell cycle and dissociate from chromatin with replication initiation. It may also serve to regulate checkpoint signaling as part of the DNA damage response. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.90267788
2protein complex biogenesis (GO:0070271)4.88120757
3proteasome assembly (GO:0043248)4.68090164
4mitochondrial respiratory chain complex assembly (GO:0033108)4.64617230
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.62866989
6cullin deneddylation (GO:0010388)4.55440486
7DNA strand elongation involved in DNA replication (GO:0006271)4.38724426
8electron transport chain (GO:0022900)4.38499466
9respiratory electron transport chain (GO:0022904)4.37944502
10water-soluble vitamin biosynthetic process (GO:0042364)4.37510251
11nucleobase biosynthetic process (GO:0046112)4.36259273
12maturation of SSU-rRNA (GO:0030490)4.33123106
13respiratory chain complex IV assembly (GO:0008535)4.33039263
14purine nucleobase biosynthetic process (GO:0009113)4.30136429
15DNA replication initiation (GO:0006270)4.27494053
16negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.26770693
17protein deneddylation (GO:0000338)4.21670298
18telomere maintenance via semi-conservative replication (GO:0032201)4.21397679
19DNA strand elongation (GO:0022616)4.16110530
20ATP synthesis coupled proton transport (GO:0015986)4.14746712
21energy coupled proton transport, down electrochemical gradient (GO:0015985)4.14746712
22DNA replication checkpoint (GO:0000076)4.13631757
23formation of translation preinitiation complex (GO:0001731)4.08791658
24cytochrome complex assembly (GO:0017004)4.06800509
25positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.06120612
26behavioral response to nicotine (GO:0035095)4.05816014
27termination of RNA polymerase III transcription (GO:0006386)4.03310137
28transcription elongation from RNA polymerase III promoter (GO:0006385)4.03310137
29establishment of protein localization to mitochondrial membrane (GO:0090151)4.02534321
30anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.01230229
31regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.98360668
32protein-cofactor linkage (GO:0018065)3.98066322
33DNA deamination (GO:0045006)3.97526024
34negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.95904655
35negative regulation of ligase activity (GO:0051352)3.95904655
367-methylguanosine mRNA capping (GO:0006370)3.95475268
37deoxyribonucleotide biosynthetic process (GO:0009263)3.93025233
38establishment of integrated proviral latency (GO:0075713)3.91080380
39RNA capping (GO:0036260)3.90867395
407-methylguanosine RNA capping (GO:0009452)3.90867395
41ribosomal large subunit biogenesis (GO:0042273)3.85490364
42chaperone-mediated protein transport (GO:0072321)3.82265005
43rRNA modification (GO:0000154)3.81753576
44ribosomal small subunit assembly (GO:0000028)3.81596371
45CENP-A containing nucleosome assembly (GO:0034080)3.80396992
46ribosome biogenesis (GO:0042254)3.80182445
47spliceosomal snRNP assembly (GO:0000387)3.74400136
48pseudouridine synthesis (GO:0001522)3.74294184
49regulation of cellular amino acid metabolic process (GO:0006521)3.73994792
50ribonucleoprotein complex biogenesis (GO:0022613)3.69488487
51L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.68942848
52deoxyribose phosphate biosynthetic process (GO:0046385)3.68478292
532-deoxyribonucleotide biosynthetic process (GO:0009265)3.68478292
54chromatin remodeling at centromere (GO:0031055)3.67106448
55DNA damage response, detection of DNA damage (GO:0042769)3.66664582
56DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.66482499
57transcription-coupled nucleotide-excision repair (GO:0006283)3.64452141
58telomere maintenance via recombination (GO:0000722)3.61720599
59signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.60418734
60intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.60418734
61signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.57031966
62signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.57031966
63signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.57031966
64rRNA processing (GO:0006364)3.55851909
65positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.54729589
66transcription elongation from RNA polymerase I promoter (GO:0006362)3.54102624
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.52689381
68tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.52689381
69regulation of mitochondrial translation (GO:0070129)3.52283854
70signal transduction involved in DNA integrity checkpoint (GO:0072401)3.51280429
71signal transduction involved in DNA damage checkpoint (GO:0072422)3.51280429
72ribosome assembly (GO:0042255)3.49872521
73signal transduction involved in cell cycle checkpoint (GO:0072395)3.46908511
74establishment of protein localization to mitochondrion (GO:0072655)3.45960967
75deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.43919370
76platelet dense granule organization (GO:0060155)3.42979873
77protein targeting to mitochondrion (GO:0006626)3.42225513
78G1/S transition of mitotic cell cycle (GO:0000082)3.41469311
79cell cycle G1/S phase transition (GO:0044843)3.41469311
80rRNA metabolic process (GO:0016072)3.39944114
81intracellular protein transmembrane import (GO:0044743)3.39292724
82positive regulation of ligase activity (GO:0051351)3.37050228
83ribosomal small subunit biogenesis (GO:0042274)3.35329431
84cellular component biogenesis (GO:0044085)3.35216457
85nucleotide-excision repair, DNA gap filling (GO:0006297)3.35030671
86mitotic recombination (GO:0006312)3.32037228
87spliceosomal complex assembly (GO:0000245)3.29801874
88DNA unwinding involved in DNA replication (GO:0006268)3.29437499
89termination of RNA polymerase I transcription (GO:0006363)3.28333828
90nucleobase-containing small molecule interconversion (GO:0015949)3.26865085
91mannosylation (GO:0097502)3.25630174
92kinetochore assembly (GO:0051382)3.25473299
93GTP biosynthetic process (GO:0006183)3.24634987
94hydrogen ion transmembrane transport (GO:1902600)3.24512812
95fucose catabolic process (GO:0019317)3.23600111
96L-fucose metabolic process (GO:0042354)3.23600111
97L-fucose catabolic process (GO:0042355)3.23600111
98translational termination (GO:0006415)3.23507407
99telomere maintenance via telomere lengthening (GO:0010833)3.23237261
100protein neddylation (GO:0045116)3.22904712
101IMP biosynthetic process (GO:0006188)3.22592058
102antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.22455120
103regulation of ubiquitin-protein transferase activity (GO:0051438)3.22185467
104protein localization to mitochondrion (GO:0070585)3.22090929
105transcription from RNA polymerase I promoter (GO:0006360)3.21006138
106translation (GO:0006412)3.20644135
107ubiquinone biosynthetic process (GO:0006744)3.20000285
108kinetochore organization (GO:0051383)3.19196583
109mitochondrial respiratory chain complex I assembly (GO:0032981)3.18522479
110NADH dehydrogenase complex assembly (GO:0010257)3.18522479
111mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.18522479
112viral transcription (GO:0019083)3.17886259
113exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.16199501
114purine nucleoside triphosphate biosynthetic process (GO:0009145)3.15981736
115establishment of viral latency (GO:0019043)3.14901956
116nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.14530935
117mitotic metaphase plate congression (GO:0007080)3.12125691
118purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.11094137
119DNA replication-independent nucleosome assembly (GO:0006336)3.11038833
120DNA replication-independent nucleosome organization (GO:0034724)3.11038833
121translational initiation (GO:0006413)3.10901361
122maturation of 5.8S rRNA (GO:0000460)3.09408308
123ATP biosynthetic process (GO:0006754)3.06818079
124tRNA processing (GO:0008033)3.04461312
125proton transport (GO:0015992)3.00268779
126negative regulation of telomere maintenance (GO:0032205)2.99463376
127amino acid salvage (GO:0043102)2.96466650
128L-methionine salvage (GO:0071267)2.96466650
129L-methionine biosynthetic process (GO:0071265)2.96466650
130DNA double-strand break processing (GO:0000729)2.96163493
131hydrogen transport (GO:0006818)2.93296329
132preassembly of GPI anchor in ER membrane (GO:0016254)2.89091386
133ubiquinone metabolic process (GO:0006743)2.87772211
134protein K6-linked ubiquitination (GO:0085020)2.87222417
135response to pheromone (GO:0019236)2.85930568
136DNA catabolic process, exonucleolytic (GO:0000738)2.81919562
137replication fork processing (GO:0031297)2.81257076
138peptidyl-histidine modification (GO:0018202)2.78283449
139ribonucleoside triphosphate biosynthetic process (GO:0009201)2.75514961
140negative regulation of heart rate (GO:0010459)2.73453422
141regulation of hexokinase activity (GO:1903299)2.69712953
142regulation of glucokinase activity (GO:0033131)2.69712953
143UTP biosynthetic process (GO:0006228)2.69149684
144inner mitochondrial membrane organization (GO:0007007)2.67202140
145tRNA modification (GO:0006400)2.66460913
146piRNA metabolic process (GO:0034587)2.64673450
147somatic hypermutation of immunoglobulin genes (GO:0016446)2.59972088
148somatic diversification of immune receptors via somatic mutation (GO:0002566)2.59972088
149intracellular protein transmembrane transport (GO:0065002)2.58341331
150positive regulation of mitochondrial fission (GO:0090141)2.58042021
151guanosine-containing compound biosynthetic process (GO:1901070)2.57847915
152tRNA metabolic process (GO:0006399)2.57383755
153kynurenine metabolic process (GO:0070189)2.56725345

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.95622945
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.72112631
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.58882214
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.07768199
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.05862983
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.04656622
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.93153378
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.70016749
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.47843861
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.38276291
11ZNF274_21170338_ChIP-Seq_K562_Hela3.28588528
12MYC_18358816_ChIP-ChIP_MESCs_Mouse3.25876533
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.24617168
14E2F4_17652178_ChIP-ChIP_JURKAT_Human3.23339716
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.18076744
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.16991833
17MYC_19079543_ChIP-ChIP_MESCs_Mouse3.10401048
18MYC_19030024_ChIP-ChIP_MESCs_Mouse3.06548753
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.93478445
20* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.86840999
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.68358602
22VDR_23849224_ChIP-Seq_CD4+_Human2.61134542
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.51743380
24VDR_22108803_ChIP-Seq_LS180_Human2.46375972
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.45042732
26DCP1A_22483619_ChIP-Seq_HELA_Human2.44499960
27XRN2_22483619_ChIP-Seq_HELA_Human2.39832830
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.33108018
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.32876937
30FOXM1_23109430_ChIP-Seq_U2OS_Human2.31872661
31SRF_21415370_ChIP-Seq_HL-1_Mouse2.16370916
32* GABP_19822575_ChIP-Seq_HepG2_Human2.12703159
33FOXP3_21729870_ChIP-Seq_TREG_Human2.12113877
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.11978036
35ELK1_19687146_ChIP-ChIP_HELA_Human2.09788277
36YY1_21170310_ChIP-Seq_MESCs_Mouse2.09600967
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.94732182
38TTF2_22483619_ChIP-Seq_HELA_Human1.93898024
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.93259094
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93078930
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91891747
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.90750291
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.90397006
44AR_21909140_ChIP-Seq_LNCAP_Human1.90347604
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.88151469
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.86525734
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.82941328
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81659313
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79122926
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.78176027
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60123810
52EWS_26573619_Chip-Seq_HEK293_Human1.58280072
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.55965412
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.53676359
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.53180700
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52785620
57IGF1R_20145208_ChIP-Seq_DFB_Human1.52087436
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.51538351
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50998485
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.50768648
61TP53_22573176_ChIP-Seq_HFKS_Human1.47580308
62GBX2_23144817_ChIP-Seq_PC3_Human1.45146801
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41869629
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41069752
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39365343
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35975844
67KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32199480
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31028412
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30586613
70KDM5A_27292631_Chip-Seq_BREAST_Human1.28495011
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24900647
72ELK1_22589737_ChIP-Seq_MCF10A_Human1.23515217
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22413621
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21965741
75CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21599544
76GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20742804
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20690486
78MYC_18940864_ChIP-ChIP_HL60_Human1.18370825
79AR_20517297_ChIP-Seq_VCAP_Human1.17596974
80SALL1_21062744_ChIP-ChIP_HESCs_Human1.17461412
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16168833
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16047709
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.14992056
84FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14992056
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13715363
86EZH2_22144423_ChIP-Seq_EOC_Human1.12701834
87ER_23166858_ChIP-Seq_MCF-7_Human1.11893270
88P300_19829295_ChIP-Seq_ESCs_Human1.11432609
89GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11370686
90ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08841371
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07591020
92TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06743621
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06336315
94NCOR_22424771_ChIP-Seq_293T_Human1.05951569
95POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05508291
96TAF15_26573619_Chip-Seq_HEK293_Human1.04161628
97KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03119412
98HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02922347
99GATA3_21878914_ChIP-Seq_MCF-7_Human1.01786911
100CIITA_25753668_ChIP-Seq_RAJI_Human1.01782642
101PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.00597750
102SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00179461
103NANOG_19829295_ChIP-Seq_ESCs_Human0.99369580
104SOX2_19829295_ChIP-Seq_ESCs_Human0.99369580
105CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98252034
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98099302
107* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98003936
108CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97992090
109SOX17_20123909_ChIP-Seq_XEN_Mouse0.96633391
110TAF2_19829295_ChIP-Seq_ESCs_Human0.96496575
111SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96179516
112SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96091777
113EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93498598
114HTT_18923047_ChIP-ChIP_STHdh_Human0.91666256
115ERA_21632823_ChIP-Seq_H3396_Human0.91514739
116HOXB7_26014856_ChIP-Seq_BT474_Human0.91006129
117KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87713322
118POU5F1_16153702_ChIP-ChIP_HESCs_Human0.86777997
119MYC_19829295_ChIP-Seq_ESCs_Human0.85278192
120TFEB_21752829_ChIP-Seq_HELA_Human0.84284146
121NANOG_20526341_ChIP-Seq_ESCs_Human0.83487958
122UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.82730838
123CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.82371254
124FOXA1_21572438_ChIP-Seq_LNCaP_Human0.80837219
125NOTCH1_21737748_ChIP-Seq_TLL_Human0.80662833
126BCAT_22108803_ChIP-Seq_LS180_Human0.79497419
127FUS_26573619_Chip-Seq_HEK293_Human0.79331476
128ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.78399548
129STAT3_1855785_ChIP-Seq_MESCs_Mouse0.77006144
130* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.76680014
131* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76404913
132DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.75856878
133CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.73480398
134TBX5_21415370_ChIP-Seq_HL-1_Mouse0.72899869
135OCT4_18692474_ChIP-Seq_MEFs_Mouse0.71376318
136SOX2_16153702_ChIP-ChIP_HESCs_Human0.71111186
137NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.70721230
138GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.69943812
139CTCF_18555785_ChIP-Seq_MESCs_Mouse0.69141114
140TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.68693698
141NANOG_16153702_ChIP-ChIP_HESCs_Human0.68307873
142SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.68186343
143IRF1_19129219_ChIP-ChIP_H3396_Human0.68090162
144CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.67235424
145FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.66917474
146SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.66667290

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.77308808
2MP0004957_abnormal_blastocyst_morpholog4.11529323
3MP0010094_abnormal_chromosome_stability3.85081504
4MP0003111_abnormal_nucleus_morphology3.58647090
5MP0003077_abnormal_cell_cycle3.21455240
6MP0008057_abnormal_DNA_replication3.03884127
7MP0008932_abnormal_embryonic_tissue3.01187433
8MP0003880_abnormal_central_pattern2.99218585
9MP0001529_abnormal_vocalization2.89920875
10MP0008058_abnormal_DNA_repair2.87812872
11MP0003123_paternal_imprinting2.74801092
12MP0002938_white_spotting2.31665554
13MP0003195_calcinosis2.30847272
14MP0008877_abnormal_DNA_methylation2.30188308
15MP0005551_abnormal_eye_electrophysiolog2.29527575
16MP0006072_abnormal_retinal_apoptosis2.19327932
17MP0008007_abnormal_cellular_replicative2.12336880
18MP0003806_abnormal_nucleotide_metabolis2.08972579
19MP0004147_increased_porphyrin_level2.08971439
20MP0003011_delayed_dark_adaptation2.08433361
21MP0003718_maternal_effect2.04608583
22MP0001730_embryonic_growth_arrest2.01939093
23MP0002837_dystrophic_cardiac_calcinosis2.01797736
24MP0005253_abnormal_eye_physiology1.85380363
25MP0002736_abnormal_nociception_after1.85078282
26MP0003786_premature_aging1.83356742
27MP0003646_muscle_fatigue1.81406461
28MP0001905_abnormal_dopamine_level1.78527309
29MP0006036_abnormal_mitochondrial_physio1.75592615
30MP0008872_abnormal_physiological_respon1.74024901
31MP0002876_abnormal_thyroid_physiology1.70564634
32MP0008875_abnormal_xenobiotic_pharmacok1.69291133
33MP0004859_abnormal_synaptic_plasticity1.66230519
34MP0002653_abnormal_ependyma_morphology1.64738772
35MP0006035_abnormal_mitochondrial_morpho1.63314033
36MP0001968_abnormal_touch/_nociception1.62073551
37MP0000350_abnormal_cell_proliferation1.59852634
38MP0005084_abnormal_gallbladder_morpholo1.56746128
39MP0002822_catalepsy1.53461531
40MP0009379_abnormal_foot_pigmentation1.48138936
41MP0003121_genomic_imprinting1.47318504
42MP0002095_abnormal_skin_pigmentation1.47143936
43MP0005646_abnormal_pituitary_gland1.44951290
44MP0001501_abnormal_sleep_pattern1.43289709
45MP0005174_abnormal_tail_pigmentation1.40201791
46MP0009745_abnormal_behavioral_response1.40101941
47MP0000427_abnormal_hair_cycle1.37985464
48MP0008260_abnormal_autophagy1.37299909
49MP0002163_abnormal_gland_morphology1.33395628
50MP0002277_abnormal_respiratory_mucosa1.33131916
51MP0004270_analgesia1.32174370
52MP0005379_endocrine/exocrine_gland_phen1.31165759
53MP0004742_abnormal_vestibular_system1.31056973
54MP0006292_abnormal_olfactory_placode1.30620490
55MP0001188_hyperpigmentation1.28916287
56MP0001697_abnormal_embryo_size1.28247073
57MP0003122_maternal_imprinting1.27511982
58MP0000631_abnormal_neuroendocrine_gland1.24692041
59MP0002064_seizures1.23725761
60MP0004142_abnormal_muscle_tone1.23663371
61MP0009764_decreased_sensitivity_to1.23582223
62MP0002160_abnormal_reproductive_system1.23384552
63MP0003635_abnormal_synaptic_transmissio1.22584978
64MP0002080_prenatal_lethality1.21579350
65MP0003186_abnormal_redox_activity1.21248921
66MP0002734_abnormal_mechanical_nocicepti1.20961271
67MP0005075_abnormal_melanosome_morpholog1.19816074
68MP0002272_abnormal_nervous_system1.18144799
69MP0002234_abnormal_pharynx_morphology1.17504674
70MP0000358_abnormal_cell_content/1.16306977
71MP0004145_abnormal_muscle_electrophysio1.15895990
72MP0009046_muscle_twitch1.13815507
73MP0005332_abnormal_amino_acid1.12212421
74MP0003656_abnormal_erythrocyte_physiolo1.11589196
75MP0002751_abnormal_autonomic_nervous1.11531282
76MP0002102_abnormal_ear_morphology1.10632741
77MP0002735_abnormal_chemical_nociception1.10177020
78MP0003315_abnormal_perineum_morphology1.09926492
79MP0001764_abnormal_homeostasis1.09211568
80MP0000313_abnormal_cell_death1.08118939
81MP0001984_abnormal_olfaction1.07880059
82MP0004885_abnormal_endolymph1.07658453
83MP0001919_abnormal_reproductive_system1.07542090
84MP0002396_abnormal_hematopoietic_system1.07133878
85MP0009697_abnormal_copulation1.06759299
86MP0005645_abnormal_hypothalamus_physiol1.06004014
87MP0005171_absent_coat_pigmentation1.05051925
88MP0005410_abnormal_fertilization1.04234348
89MP0004133_heterotaxia1.00918443
90MP0010386_abnormal_urinary_bladder1.00189422
91MP0002063_abnormal_learning/memory/cond0.99361148
92MP0003136_yellow_coat_color0.98572782
93MP0003137_abnormal_impulse_conducting0.98091218
94MP0001293_anophthalmia0.97937062
95MP0002638_abnormal_pupillary_reflex0.97379851
96MP0005380_embryogenesis_phenotype0.97217480
97MP0001672_abnormal_embryogenesis/_devel0.97217480
98MP0002557_abnormal_social/conspecific_i0.96703612
99MP0004215_abnormal_myocardial_fiber0.96501558
100MP0001440_abnormal_grooming_behavior0.95049249
101MP0001324_abnormal_eye_pigmentation0.94904676
102MP0004084_abnormal_cardiac_muscle0.93995665
103MP0001727_abnormal_embryo_implantation0.93643566
104MP0002210_abnormal_sex_determination0.93584265
105MP0002572_abnormal_emotion/affect_behav0.93521978
106MP0001486_abnormal_startle_reflex0.92953185
107MP0005389_reproductive_system_phenotype0.92572062
108MP0002085_abnormal_embryonic_tissue0.92177636
109MP0000015_abnormal_ear_pigmentation0.89594924
110MP0000372_irregular_coat_pigmentation0.89506906
111MP0005386_behavior/neurological_phenoty0.89323364
112MP0004924_abnormal_behavior0.89323364
113MP0005195_abnormal_posterior_eye0.88014903
114MP0003984_embryonic_growth_retardation0.86929713
115MP0004043_abnormal_pH_regulation0.85696344
116MP0003221_abnormal_cardiomyocyte_apopto0.85444358
117MP0009333_abnormal_splenocyte_physiolog0.84699791
118MP0003950_abnormal_plasma_membrane0.83613703
119MP0001145_abnormal_male_reproductive0.82967011
120MP0002088_abnormal_embryonic_growth/wei0.82904147
121MP0000749_muscle_degeneration0.82736979
122MP0002067_abnormal_sensory_capabilities0.81423051
123MP0001485_abnormal_pinna_reflex0.81343851
124MP0001970_abnormal_pain_threshold0.80240806
125MP0002229_neurodegeneration0.79155966
126MP0006276_abnormal_autonomic_nervous0.78901654
127MP0002733_abnormal_thermal_nociception0.78877827
128MP0005167_abnormal_blood-brain_barrier0.77735826
129MP0008789_abnormal_olfactory_epithelium0.77377074
130MP0000647_abnormal_sebaceous_gland0.77096854
131MP0005423_abnormal_somatic_nervous0.76773162
132MP0002693_abnormal_pancreas_physiology0.75708828
133MP0003283_abnormal_digestive_organ0.75631343
134MP0002132_abnormal_respiratory_system0.73325052
135MP0004233_abnormal_muscle_weight0.72901540
136MP0003698_abnormal_male_reproductive0.71094296
137MP0005408_hypopigmentation0.70833498
138MP0000653_abnormal_sex_gland0.70550433
139MP0003938_abnormal_ear_development0.70538901
140MP0001986_abnormal_taste_sensitivity0.70426155
141MP0002752_abnormal_somatic_nervous0.69991780
142MP0000538_abnormal_urinary_bladder0.69971170
143MP0003329_amyloid_beta_deposits0.69826421
144MP0005394_taste/olfaction_phenotype0.69450854
145MP0005499_abnormal_olfactory_system0.69450854
146MP0005384_cellular_phenotype0.69161719
147MP0001929_abnormal_gametogenesis0.68428501
148MP0002184_abnormal_innervation0.67772592
149MP0002084_abnormal_developmental_patter0.65805458
150MP0003567_abnormal_fetal_cardiomyocyte0.65110684
151MP0002019_abnormal_tumor_incidence0.64527448
152MP0005266_abnormal_metabolism0.64342978

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.27976178
2Abnormality of glycolysis (HP:0004366)5.15742716
3Increased serum pyruvate (HP:0003542)5.15742716
4Acute necrotizing encephalopathy (HP:0006965)4.79855255
5Abnormal mitochondria in muscle tissue (HP:0008316)4.40099471
6Mitochondrial inheritance (HP:0001427)4.25338919
7Cerebral hypomyelination (HP:0006808)4.21861841
8Increased CSF lactate (HP:0002490)3.98810332
9Hepatocellular necrosis (HP:0001404)3.88343969
10Breast hypoplasia (HP:0003187)3.84849803
11Progressive macrocephaly (HP:0004481)3.82212111
12Acute encephalopathy (HP:0006846)3.66240839
13Abnormality of cells of the erythroid lineage (HP:0012130)3.55843921
14Pancreatic cysts (HP:0001737)3.49618847
15Abnormal number of erythroid precursors (HP:0012131)3.39263924
16Increased serum lactate (HP:0002151)3.37787115
17Abnormality of midbrain morphology (HP:0002418)3.13755877
18Molar tooth sign on MRI (HP:0002419)3.13755877
19Hepatic necrosis (HP:0002605)3.06956952
20Type II lissencephaly (HP:0007260)3.02347539
21Abnormality of the heme biosynthetic pathway (HP:0010472)3.00457446
22Congenital stationary night blindness (HP:0007642)3.00454466
23Agnosia (HP:0010524)3.00373657
24Pancreatic fibrosis (HP:0100732)2.96409424
25Rough bone trabeculation (HP:0100670)2.93677830
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.91019953
27Decreased activity of mitochondrial respiratory chain (HP:0008972)2.91019953
28True hermaphroditism (HP:0010459)2.90640612
29Increased hepatocellular lipid droplets (HP:0006565)2.90260751
30Hypoplasia of the capital femoral epiphysis (HP:0003090)2.82533521
313-Methylglutaconic aciduria (HP:0003535)2.79798610
32Oral leukoplakia (HP:0002745)2.78958315
33Respiratory failure (HP:0002878)2.76989189
34Pendular nystagmus (HP:0012043)2.74154754
35Exercise intolerance (HP:0003546)2.72024053
36Abnormality of alanine metabolism (HP:0010916)2.71301389
37Hyperalaninemia (HP:0003348)2.71301389
38Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.71301389
39Postnatal microcephaly (HP:0005484)2.70994503
40Decreased electroretinogram (ERG) amplitude (HP:0000654)2.70604468
41Congenital, generalized hypertrichosis (HP:0004540)2.64480051
42Abnormality of the labia minora (HP:0012880)2.63129582
43Lactic acidosis (HP:0003128)2.62633076
44Reticulocytopenia (HP:0001896)2.61635277
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.60013751
46Leukodystrophy (HP:0002415)2.58930283
47Macrocytic anemia (HP:0001972)2.56706687
48Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.54533492
49Nephronophthisis (HP:0000090)2.52997901
50Large for gestational age (HP:0001520)2.52974540
51Degeneration of anterior horn cells (HP:0002398)2.48095859
52Abnormality of the anterior horn cell (HP:0006802)2.48095859
53Methylmalonic aciduria (HP:0012120)2.47566822
54Lipid accumulation in hepatocytes (HP:0006561)2.46786308
55Patellar aplasia (HP:0006443)2.46411497
56CNS hypomyelination (HP:0003429)2.44905394
57Delusions (HP:0000746)2.41889585
58Abolished electroretinogram (ERG) (HP:0000550)2.39613045
59Emotional lability (HP:0000712)2.38999414
60Unsteady gait (HP:0002317)2.38751996
61Methylmalonic acidemia (HP:0002912)2.38723337
62Aplastic anemia (HP:0001915)2.38134550
63CNS demyelination (HP:0007305)2.35767194
64Carpal bone hypoplasia (HP:0001498)2.33548948
65Irregular epiphyses (HP:0010582)2.31089781
66Aplasia/Hypoplasia of the patella (HP:0006498)2.30298033
67Premature graying of hair (HP:0002216)2.29393709
68Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.29061631
69Absent epiphyses (HP:0010577)2.29061631
70Lethargy (HP:0001254)2.27110429
71Medial flaring of the eyebrow (HP:0010747)2.26500773
72Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.24694807
73Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.22346415
74Optic disc pallor (HP:0000543)2.19389615
75Absent radius (HP:0003974)2.18699256
76Attenuation of retinal blood vessels (HP:0007843)2.18356721
77Progressive microcephaly (HP:0000253)2.18319957
78Cerebral edema (HP:0002181)2.17692721
79Retinal dysplasia (HP:0007973)2.14283997
80Poor head control (HP:0002421)2.13392495
81Abnormal trabecular bone morphology (HP:0100671)2.13302164
82Increased muscle lipid content (HP:0009058)2.10936685
83Absent forearm bone (HP:0003953)2.10813557
84Aplasia involving forearm bones (HP:0009822)2.10813557
85Abnormality of the renal cortex (HP:0011035)2.09503509
86Renal Fanconi syndrome (HP:0001994)2.03845578
87Microvesicular hepatic steatosis (HP:0001414)2.02130348
88Abnormality of the preputium (HP:0100587)2.02075131
89Lissencephaly (HP:0001339)2.00435839
90Colon cancer (HP:0003003)2.00403611
91Bile duct proliferation (HP:0001408)1.99609408
92Abnormal biliary tract physiology (HP:0012439)1.99609408
93Pallor (HP:0000980)1.99275449
94Abnormality of renal resorption (HP:0011038)1.98578964
95Horseshoe kidney (HP:0000085)1.98292874
96Secondary amenorrhea (HP:0000869)1.98077858
97Meckel diverticulum (HP:0002245)1.97346569
98Neuroendocrine neoplasm (HP:0100634)1.97216246
99Cellular immunodeficiency (HP:0005374)1.96108748
100Microretrognathia (HP:0000308)1.96038296
101Hyperglycinuria (HP:0003108)1.95923891
102Abnormality of the renal medulla (HP:0100957)1.95888617
103Increased intramyocellular lipid droplets (HP:0012240)1.94189966
104Sclerocornea (HP:0000647)1.94106207
105Respiratory difficulties (HP:0002880)1.93589959
106Fibular aplasia (HP:0002990)1.93515351
107Inability to walk (HP:0002540)1.92830000
108Hypoplastic pelvis (HP:0008839)1.92549945
109Aplasia/hypoplasia of the uterus (HP:0008684)1.91374803
110Abnormality of urine glucose concentration (HP:0011016)1.90975456
111Glycosuria (HP:0003076)1.90975456
112Cerebellar dysplasia (HP:0007033)1.89405358
113Type I transferrin isoform profile (HP:0003642)1.88768614
114Severe muscular hypotonia (HP:0006829)1.87525974
115Abnormality of the ileum (HP:0001549)1.87380694
116Abnormality of serum amino acid levels (HP:0003112)1.87207797
117Abnormality of the pons (HP:0007361)1.85879947
118Aplasia/Hypoplasia of the sacrum (HP:0008517)1.85841844
119Medulloblastoma (HP:0002885)1.85785352
120Megaloblastic anemia (HP:0001889)1.85219438
121Poor suck (HP:0002033)1.83525711
122Exertional dyspnea (HP:0002875)1.81174859
123Neuroblastoma (HP:0003006)1.80633729
124Primitive neuroectodermal tumor (HP:0030065)1.80633729
125Neuroblastic tumors (HP:0004376)1.80633729
126Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.80633729
127Chorioretinal atrophy (HP:0000533)1.78706010
128Constricted visual fields (HP:0001133)1.78358037
129Generalized aminoaciduria (HP:0002909)1.78305414
130Cystic liver disease (HP:0006706)1.77751856
131Hypoplasia of the pons (HP:0012110)1.77541905
132Pheochromocytoma (HP:0002666)1.77022128
133Pancytopenia (HP:0001876)1.76946405
134Bone marrow hypocellularity (HP:0005528)1.76090292
135Renal cortical cysts (HP:0000803)1.76045331
136Absent thumb (HP:0009777)1.76042408
137Concave nail (HP:0001598)1.75616283
138Furrowed tongue (HP:0000221)1.75405694
139Triphalangeal thumb (HP:0001199)1.74731487
140Ketoacidosis (HP:0001993)1.74494111
141Short tibia (HP:0005736)1.74478590
142Abnormal protein glycosylation (HP:0012346)1.73006356
143Abnormal glycosylation (HP:0012345)1.73006356
144Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.73006356
145Abnormal protein N-linked glycosylation (HP:0012347)1.73006356
146Aplasia/Hypoplasia of the tibia (HP:0005772)1.72928777
147Aplasia/Hypoplasia of the fovea (HP:0008060)1.71931092
148Hypoplasia of the fovea (HP:0007750)1.71931092
149Abnormality of chromosome stability (HP:0003220)1.71697042
150Epileptic encephalopathy (HP:0200134)1.71203421
151Abnormal rod and cone electroretinograms (HP:0008323)1.70772547
152Glossoptosis (HP:0000162)1.70651872
153Blindness (HP:0000618)1.68507754
154Male pseudohermaphroditism (HP:0000037)1.67711713
155Opisthotonus (HP:0002179)1.67538813
156Neoplasm of the pancreas (HP:0002894)1.66890822

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.54069338
2EIF2AK13.93172195
3WEE13.76428652
4VRK23.52263993
5BMPR1B3.28278435
6TSSK63.15351914
7STK163.03375411
8CDK193.01254141
9CDC72.93009952
10FRK2.82588913
11MAP4K22.77796851
12CCNB12.38808393
13NME12.26687295
14NEK12.25316100
15INSRR2.24940353
16NME22.21106349
17EIF2AK32.20336213
18NUAK12.18549998
19SRPK12.15591311
20PLK41.92986306
21TESK21.90043399
22WNK31.86555116
23CASK1.84689242
24VRK11.83800293
25PINK11.82717523
26GRK11.79093150
27BRSK21.78879902
28TLK11.71140319
29PLK21.67936172
30PLK31.62650959
31BRSK11.58469379
32PDK21.53817625
33MKNK11.46872620
34BRAF1.46448437
35MAP3K121.40007290
36AURKA1.38412546
37AKT31.35935372
38TAOK31.35921491
39PLK11.35441697
40DAPK11.35336587
41TRIM281.31049820
42ARAF1.28595289
43PNCK1.26124207
44MKNK21.22401891
45MST41.22228125
46SCYL21.21131851
47TTK1.15953142
48PBK1.13953399
49WNK41.09915663
50LIMK11.07666424
51ACVR1B1.05859743
52OXSR11.05182903
53BCR1.02839508
54TAF11.01743585
55MUSK1.00833496
56CHEK21.00702564
57ADRBK11.00488328
58TXK0.94621568
59MAP2K70.91978259
60AURKB0.88431826
61CSNK1G10.87248708
62PHKG20.86826227
63PHKG10.86826227
64PIM20.86234030
65CDK140.82013557
66CDK180.81777335
67CSNK1G20.80809662
68ATR0.80354417
69CDK11A0.80213281
70PRPF4B0.80180945
71MINK10.77147416
72CDK150.76137040
73EPHA40.75382715
74TGFBR10.74639660
75ZAK0.72716075
76PAK30.72499674
77PRKCE0.71438987
78RPS6KA50.71339566
79TNIK0.69954361
80MAPKAPK30.69762368
81TESK10.69638185
82CDK70.69179148
83PAK10.68041086
84NEK20.67665484
85CSNK2A20.67265630
86CDK80.66971519
87CHEK10.64771852
88CSNK2A10.63217118
89DAPK30.63139667
90MAP3K80.62315980
91RAF10.61476662
92PRKCG0.60043891
93NTRK30.59870847
94CSNK1A1L0.59161242
95IKBKB0.57592974
96GRK70.56634128
97DYRK20.55825427
98CSNK1G30.53996511
99MYLK0.52510974
100MAP3K40.52395515
101CAMK2B0.52378335
102CAMKK20.50805599
103PDK40.50792114
104PDK30.50792114
105MARK10.50476001
106GRK50.48913298
107MAP2K60.46526168
108CSNK1A10.46395302
109SIK30.46359590
110CAMK2A0.46095596
111PIK3CG0.45895930
112DAPK20.45879556
113ILK0.44966260
114PKN10.44289834
115EIF2AK20.44134825
116MAPKAPK50.43979961
117ABL20.43824963
118PRKCI0.43788479
119EPHA20.43504407
120PRKCQ0.41658600
121BCKDK0.40949106
122PASK0.40390601
123CDK20.40018028
124RPS6KB20.39986375
125KDR0.39870234
126PAK40.39792241
127CDK10.37794930
128KSR10.36898820
129CAMK10.36477546
130FES0.35776014
131PTK2B0.35377413
132STK40.35248587
133MAP3K110.35106263
134ATM0.34282952
135PRKACA0.33703615
136NEK60.33616260
137MARK30.32953193
138ADRBK20.32869133
139MAPK130.32227426
140UHMK10.30693338
141CLK10.29567336

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.79088822
2DNA replication_Homo sapiens_hsa030304.16238984
3RNA polymerase_Homo sapiens_hsa030203.73293816
4Mismatch repair_Homo sapiens_hsa034303.66753201
5Ribosome_Homo sapiens_hsa030103.63043087
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.41150103
7Oxidative phosphorylation_Homo sapiens_hsa001903.15258534
8Nucleotide excision repair_Homo sapiens_hsa034202.83039269
9Parkinsons disease_Homo sapiens_hsa050122.77338434
10Spliceosome_Homo sapiens_hsa030402.76157654
11RNA transport_Homo sapiens_hsa030132.50608475
12Pyrimidine metabolism_Homo sapiens_hsa002402.46548300
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.46491122
14Homologous recombination_Homo sapiens_hsa034402.39703448
15Huntingtons disease_Homo sapiens_hsa050162.15309855
16Base excision repair_Homo sapiens_hsa034102.06625697
17Basal transcription factors_Homo sapiens_hsa030221.91255216
18One carbon pool by folate_Homo sapiens_hsa006701.89169412
19Alzheimers disease_Homo sapiens_hsa050101.87671516
20Cell cycle_Homo sapiens_hsa041101.82566681
21Protein export_Homo sapiens_hsa030601.81003272
22Fanconi anemia pathway_Homo sapiens_hsa034601.67688700
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.61984651
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.60179660
25RNA degradation_Homo sapiens_hsa030181.59068240
26Purine metabolism_Homo sapiens_hsa002301.52417341
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.42563533
28Non-homologous end-joining_Homo sapiens_hsa034501.38701200
29Butanoate metabolism_Homo sapiens_hsa006501.35552377
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35473062
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.31704913
32Propanoate metabolism_Homo sapiens_hsa006401.21157615
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20783716
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.19902992
35Selenocompound metabolism_Homo sapiens_hsa004501.18209367
36Collecting duct acid secretion_Homo sapiens_hsa049661.17618881
37Cardiac muscle contraction_Homo sapiens_hsa042601.12409066
38Tryptophan metabolism_Homo sapiens_hsa003801.12065279
39Oocyte meiosis_Homo sapiens_hsa041141.11217143
40Peroxisome_Homo sapiens_hsa041461.10930932
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.05620193
42mRNA surveillance pathway_Homo sapiens_hsa030151.03398036
43Vitamin B6 metabolism_Homo sapiens_hsa007501.01654565
44Nitrogen metabolism_Homo sapiens_hsa009101.01315429
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00723668
46Synaptic vesicle cycle_Homo sapiens_hsa047210.97854687
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93650545
48Vibrio cholerae infection_Homo sapiens_hsa051100.93213813
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92814979
50Sulfur metabolism_Homo sapiens_hsa009200.92262972
51Epstein-Barr virus infection_Homo sapiens_hsa051690.92113089
52Linoleic acid metabolism_Homo sapiens_hsa005910.90366800
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.88326918
54Biosynthesis of amino acids_Homo sapiens_hsa012300.84939104
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84371933
56Nicotine addiction_Homo sapiens_hsa050330.82989071
57Caffeine metabolism_Homo sapiens_hsa002320.80328086
58beta-Alanine metabolism_Homo sapiens_hsa004100.77762638
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.76541481
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76119512
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.75526274
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72704251
63Folate biosynthesis_Homo sapiens_hsa007900.70909677
64p53 signaling pathway_Homo sapiens_hsa041150.70123935
65Carbon metabolism_Homo sapiens_hsa012000.68680998
66Chemical carcinogenesis_Homo sapiens_hsa052040.66493958
67Systemic lupus erythematosus_Homo sapiens_hsa053220.66420098
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65998299
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65820899
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.63121753
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60573161
72Glutathione metabolism_Homo sapiens_hsa004800.60066925
73Pentose phosphate pathway_Homo sapiens_hsa000300.59427527
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59303365
75Asthma_Homo sapiens_hsa053100.58164394
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57237977
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54982770
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54336522
79Metabolic pathways_Homo sapiens_hsa011000.54331517
80Alcoholism_Homo sapiens_hsa050340.53516492
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52345250
82Pyruvate metabolism_Homo sapiens_hsa006200.51002953
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50468210
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49909391
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48679142
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44770746
87Vitamin digestion and absorption_Homo sapiens_hsa049770.43137154
88Mineral absorption_Homo sapiens_hsa049780.42886525
89Fructose and mannose metabolism_Homo sapiens_hsa000510.42112456
90Olfactory transduction_Homo sapiens_hsa047400.40729973
91Primary immunodeficiency_Homo sapiens_hsa053400.39246028
92Regulation of autophagy_Homo sapiens_hsa041400.38797097
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36950433
94N-Glycan biosynthesis_Homo sapiens_hsa005100.36857551
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36296855
96Taste transduction_Homo sapiens_hsa047420.35298211
97Long-term potentiation_Homo sapiens_hsa047200.34768568
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.34434039
99Amphetamine addiction_Homo sapiens_hsa050310.32676555
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32609531
101Sulfur relay system_Homo sapiens_hsa041220.32544345
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31854699
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31800266
104Viral carcinogenesis_Homo sapiens_hsa052030.30271614
105Phototransduction_Homo sapiens_hsa047440.29255896
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28632492
107Phagosome_Homo sapiens_hsa041450.27365221
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25944990
109Fatty acid metabolism_Homo sapiens_hsa012120.24497680
110Tyrosine metabolism_Homo sapiens_hsa003500.23805166
111Insulin secretion_Homo sapiens_hsa049110.21314746
112Fatty acid degradation_Homo sapiens_hsa000710.21167183
113Rheumatoid arthritis_Homo sapiens_hsa053230.20541627
114Serotonergic synapse_Homo sapiens_hsa047260.20373725
115Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.20120661
116Dopaminergic synapse_Homo sapiens_hsa047280.19322951
117Renin-angiotensin system_Homo sapiens_hsa046140.15786715
118Steroid biosynthesis_Homo sapiens_hsa001000.15723256
119Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.15283112
120Shigellosis_Homo sapiens_hsa051310.14363165
121Antigen processing and presentation_Homo sapiens_hsa046120.13222902
122Long-term depression_Homo sapiens_hsa047300.13066972
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.12775139
124Arachidonic acid metabolism_Homo sapiens_hsa005900.09381899
125Type I diabetes mellitus_Homo sapiens_hsa049400.08907163
126GABAergic synapse_Homo sapiens_hsa047270.08499868
127Arginine and proline metabolism_Homo sapiens_hsa003300.07878573
128Thyroid cancer_Homo sapiens_hsa052160.06809460
129HIF-1 signaling pathway_Homo sapiens_hsa040660.06475076
130Fatty acid elongation_Homo sapiens_hsa000620.06360494
131Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.06226859
132Morphine addiction_Homo sapiens_hsa050320.06164719
133Ether lipid metabolism_Homo sapiens_hsa005650.05375927
134Gap junction_Homo sapiens_hsa045400.04384527
135Drug metabolism - other enzymes_Homo sapiens_hsa009830.03961891
136HTLV-I infection_Homo sapiens_hsa051660.03731600
137Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.00863996
138Circadian entrainment_Homo sapiens_hsa04713-0.0004886

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