

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | protein K11-linked deubiquitination (GO:0035871) | 5.47281303 |
| 2 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 5.42083089 |
| 3 | actin-myosin filament sliding (GO:0033275) | 5.33359187 |
| 4 | muscle filament sliding (GO:0030049) | 5.33359187 |
| 5 | regulation of relaxation of muscle (GO:1901077) | 4.66729485 |
| 6 | actin-mediated cell contraction (GO:0070252) | 4.51116135 |
| 7 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 4.50375612 |
| 8 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 4.36178757 |
| 9 | myofibril assembly (GO:0030239) | 4.25906773 |
| 10 | skeletal muscle contraction (GO:0003009) | 4.25305046 |
| 11 | response to stimulus involved in regulation of muscle adaptation (GO:0014874) | 4.21040288 |
| 12 | synaptic vesicle maturation (GO:0016188) | 4.18900879 |
| 13 | locomotory exploration behavior (GO:0035641) | 4.08962681 |
| 14 | striated muscle contraction (GO:0006941) | 4.08518838 |
| 15 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 3.97212822 |
| 16 | cilium or flagellum-dependent cell motility (GO:0001539) | 3.97099704 |
| 17 | regulation of skeletal muscle contraction (GO:0014819) | 3.96117272 |
| 18 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 3.95476595 |
| 19 | regulation of actin filament-based movement (GO:1903115) | 3.94102382 |
| 20 | sarcomere organization (GO:0045214) | 3.80619952 |
| 21 | vocalization behavior (GO:0071625) | 3.77149888 |
| 22 | cellular potassium ion homeostasis (GO:0030007) | 3.69425196 |
| 23 | carnitine transmembrane transport (GO:1902603) | 3.68353941 |
| 24 | cardiac myofibril assembly (GO:0055003) | 3.68285301 |
| 25 | synaptic vesicle exocytosis (GO:0016079) | 3.65297662 |
| 26 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 3.60698404 |
| 27 | glutamate secretion (GO:0014047) | 3.60594251 |
| 28 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.58182962 |
| 29 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 3.50266386 |
| 30 | skeletal muscle adaptation (GO:0043501) | 3.44942459 |
| 31 | sodium ion export (GO:0071436) | 3.44756385 |
| 32 | regulation of synapse structural plasticity (GO:0051823) | 3.43600647 |
| 33 | cardiac muscle contraction (GO:0060048) | 3.42850479 |
| 34 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.39934955 |
| 35 | gamma-aminobutyric acid transport (GO:0015812) | 3.39625641 |
| 36 | amino-acid betaine transport (GO:0015838) | 3.39179374 |
| 37 | carnitine transport (GO:0015879) | 3.39179374 |
| 38 | axonemal dynein complex assembly (GO:0070286) | 3.37531403 |
| 39 | actin filament-based movement (GO:0030048) | 3.36476989 |
| 40 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.35131912 |
| 41 | serotonin receptor signaling pathway (GO:0007210) | 3.35020629 |
| 42 | neurotransmitter secretion (GO:0007269) | 3.28921246 |
| 43 | regulation of synaptic vesicle exocytosis (GO:2000300) | 3.27107146 |
| 44 | neuronal action potential propagation (GO:0019227) | 3.25481284 |
| 45 | righting reflex (GO:0060013) | 3.23665133 |
| 46 | regulation of glutamate receptor signaling pathway (GO:1900449) | 3.21833539 |
| 47 | response to inactivity (GO:0014854) | 3.19707543 |
| 48 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 3.17767675 |
| 49 | cerebellar granule cell differentiation (GO:0021707) | 3.16520257 |
| 50 | central nervous system myelination (GO:0022010) | 3.15862406 |
| 51 | axon ensheathment in central nervous system (GO:0032291) | 3.15862406 |
| 52 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.14357524 |
| 53 | regulation of sarcomere organization (GO:0060297) | 3.12850955 |
| 54 | creatine metabolic process (GO:0006600) | 3.11881641 |
| 55 | neurotransmitter uptake (GO:0001504) | 3.11222406 |
| 56 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 3.11092324 |
| 57 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.07204878 |
| 58 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.07161953 |
| 59 | L-amino acid import (GO:0043092) | 3.06411346 |
| 60 | neuromuscular synaptic transmission (GO:0007274) | 3.06255916 |
| 61 | potassium ion import (GO:0010107) | 3.05908325 |
| 62 | cardiac muscle hypertrophy (GO:0003300) | 3.05507539 |
| 63 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 3.04758825 |
| 64 | glutamate receptor signaling pathway (GO:0007215) | 3.04616759 |
| 65 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.04052487 |
| 66 | regulation of synaptic vesicle transport (GO:1902803) | 3.04041578 |
| 67 | carnitine metabolic process (GO:0009437) | 3.00528804 |
| 68 | muscle contraction (GO:0006936) | 2.98559524 |
| 69 | actomyosin structure organization (GO:0031032) | 2.97079764 |
| 70 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 2.95150722 |
| 71 | cerebellar Purkinje cell differentiation (GO:0021702) | 2.94629728 |
| 72 | striated muscle hypertrophy (GO:0014897) | 2.94322101 |
| 73 | startle response (GO:0001964) | 2.93708235 |
| 74 | regulation of calcineurin-NFAT signaling cascade (GO:0070884) | 2.93665281 |
| 75 | synaptic transmission, glutamatergic (GO:0035249) | 2.93556968 |
| 76 | long-term memory (GO:0007616) | 2.92391860 |
| 77 | positive regulation of calcium ion transmembrane transporter activity (GO:1901021) | 2.92266144 |
| 78 | prepulse inhibition (GO:0060134) | 2.92145257 |
| 79 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 2.91904302 |
| 80 | regulation of cardiac muscle cell contraction (GO:0086004) | 2.91060635 |
| 81 | regulation of appetite (GO:0032098) | 2.90238089 |
| 82 | exploration behavior (GO:0035640) | 2.89498056 |
| 83 | neuron-neuron synaptic transmission (GO:0007270) | 2.88805921 |
| 84 | dendrite morphogenesis (GO:0048813) | 2.87192792 |
| 85 | protein localization to synapse (GO:0035418) | 2.87048062 |
| 86 | cell communication by electrical coupling (GO:0010644) | 2.85150424 |
| 87 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 2.81853314 |
| 88 | alanine transport (GO:0032328) | 2.80104165 |
| 89 | positive regulation of sodium ion transport (GO:0010765) | 2.80007138 |
| 90 | striated muscle adaptation (GO:0014888) | 2.78919076 |
| 91 | glycine transport (GO:0015816) | 2.78559999 |
| 92 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 2.77425086 |
| 93 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 2.76653968 |
| 94 | behavioral response to cocaine (GO:0048148) | 2.75914354 |
| 95 | proline transport (GO:0015824) | 2.75734224 |
| 96 | neuromuscular process controlling balance (GO:0050885) | 2.75532206 |
| 97 | detection of calcium ion (GO:0005513) | 2.75088626 |
| 98 | aspartate family amino acid catabolic process (GO:0009068) | 2.73951190 |
| 99 | regulation of voltage-gated calcium channel activity (GO:1901385) | 2.73774309 |
| 100 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 2.73386335 |
| 101 | membrane hyperpolarization (GO:0060081) | 2.73284319 |
| 102 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 2.73172772 |
| 103 | auditory behavior (GO:0031223) | 2.72826803 |
| 104 | neurotransmitter transport (GO:0006836) | 2.72810904 |
| 105 | quaternary ammonium group transport (GO:0015697) | 2.72785296 |
| 106 | postsynaptic membrane organization (GO:0001941) | 2.71332919 |
| 107 | plasma membrane repair (GO:0001778) | 2.70588637 |
| 108 | layer formation in cerebral cortex (GO:0021819) | 2.70266112 |
| 109 | neuron cell-cell adhesion (GO:0007158) | 2.70224969 |
| 110 | cell communication involved in cardiac conduction (GO:0086065) | 2.70223739 |
| 111 | regulation of sodium ion transmembrane transport (GO:1902305) | 2.69861220 |
| 112 | membrane depolarization during action potential (GO:0086010) | 2.69103771 |
| 113 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 2.69088753 |
| 114 | skeletal muscle fiber development (GO:0048741) | 2.68369431 |
| 115 | striatum development (GO:0021756) | 2.68167954 |
| 116 | activation of protein kinase A activity (GO:0034199) | 2.66740881 |
| 117 | muscle system process (GO:0003012) | 2.66442586 |
| 118 | myotube cell development (GO:0014904) | 2.66400374 |
| 119 | C4-dicarboxylate transport (GO:0015740) | 2.65379659 |
| 120 | potassium ion homeostasis (GO:0055075) | 2.64881471 |
| 121 | regulation of postsynaptic membrane potential (GO:0060078) | 2.64539945 |
| 122 | regulation of dendritic spine morphogenesis (GO:0061001) | 2.64427094 |
| 123 | regulation of ARF protein signal transduction (GO:0032012) | 2.63763091 |
| 124 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 2.63364471 |
| 125 | cilium movement (GO:0003341) | 2.63142680 |
| 126 | dendritic spine morphogenesis (GO:0060997) | 2.62792982 |
| 127 | motile cilium assembly (GO:0044458) | 2.60926395 |
| 128 | transmission of nerve impulse (GO:0019226) | 2.60663715 |
| 129 | cellular sodium ion homeostasis (GO:0006883) | 2.60039046 |
| 130 | adult walking behavior (GO:0007628) | 2.59884157 |
| 131 | neuromuscular process controlling posture (GO:0050884) | 2.59315857 |
| 132 | regulation of acyl-CoA biosynthetic process (GO:0050812) | 2.58800749 |
| 133 | regulation of potassium ion transmembrane transporter activity (GO:1901016) | 2.58773320 |
| 134 | regulation of neurotransmitter levels (GO:0001505) | 2.58527508 |
| 135 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 2.57563069 |
| 136 | muscle fiber development (GO:0048747) | 2.57397604 |
| 137 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 2.56726006 |
| 138 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 2.55953455 |
| 139 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 2.55054027 |
| 140 | myotube differentiation (GO:0014902) | 2.54892830 |
| 141 | cellular response to electrical stimulus (GO:0071257) | 2.53419457 |
| 142 | long-term synaptic potentiation (GO:0060291) | 2.53217411 |
| 143 | regulation of synaptic plasticity (GO:0048167) | 2.51352973 |
| 144 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 2.51308553 |
| 145 | regulation of membrane repolarization (GO:0060306) | 2.49964454 |
| 146 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 2.49318965 |
| 147 | regulation of calcium ion transmembrane transport (GO:1903169) | 2.49307517 |
| 148 | regulation of calcium ion transmembrane transporter activity (GO:1901019) | 2.49307517 |
| 149 | positive regulation of membrane potential (GO:0045838) | 2.48788429 |
| 150 | regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) | 2.46546737 |
| 151 | membrane depolarization (GO:0051899) | 2.42205176 |
| 152 | membrane repolarization (GO:0086009) | 2.39562230 |
| 153 | positive regulation of potassium ion transport (GO:0043268) | 2.39069215 |
| 154 | dicarboxylic acid catabolic process (GO:0043649) | 2.38972420 |
| 155 | presynaptic membrane organization (GO:0097090) | 2.38653016 |
| 156 | response to auditory stimulus (GO:0010996) | 2.36492379 |
| 157 | response to histamine (GO:0034776) | 2.36057293 |
| 158 | neuron recognition (GO:0008038) | 2.35947530 |
| 159 | alpha-linolenic acid metabolic process (GO:0036109) | 2.35848469 |
| 160 | dicarboxylic acid biosynthetic process (GO:0043650) | 2.34771041 |
| 161 | neuronal ion channel clustering (GO:0045161) | 2.34284732 |
| 162 | axonal fasciculation (GO:0007413) | 2.34010274 |
| 163 | acidic amino acid transport (GO:0015800) | 2.32841127 |
| 164 | macroautophagy (GO:0016236) | 2.32294805 |
| 165 | regulation of cell communication by electrical coupling (GO:0010649) | 2.32178289 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 4.29511346 |
| 2 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.57067688 |
| 3 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.56675012 |
| 4 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.52939624 |
| 5 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.49836275 |
| 6 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.49771404 |
| 7 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.39184087 |
| 8 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.22470912 |
| 9 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.20125669 |
| 10 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.16116793 |
| 11 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.16116793 |
| 12 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.14621428 |
| 13 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.09603890 |
| 14 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 2.09154079 |
| 15 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.99840151 |
| 16 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.98872551 |
| 17 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.97588409 |
| 18 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 1.97289559 |
| 19 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 1.97001589 |
| 20 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.96406832 |
| 21 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.94079270 |
| 22 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.89394592 |
| 23 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.81741351 |
| 24 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.77316898 |
| 25 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.67136165 |
| 26 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.66335686 |
| 27 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.63681309 |
| 28 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.62702186 |
| 29 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.59249593 |
| 30 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.56355617 |
| 31 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.54540539 |
| 32 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.54259351 |
| 33 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.47437792 |
| 34 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.43841198 |
| 35 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.42840448 |
| 36 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.42760877 |
| 37 | VDR_22108803_ChIP-Seq_LS180_Human | 1.40879138 |
| 38 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.39594863 |
| 39 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.39245165 |
| 40 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.37896044 |
| 41 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.37174597 |
| 42 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.36587694 |
| 43 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.35077815 |
| 44 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.33065220 |
| 45 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.32680432 |
| 46 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.31975450 |
| 47 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.31924452 |
| 48 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.30699849 |
| 49 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.30157832 |
| 50 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.29248960 |
| 51 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.28142569 |
| 52 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.27223502 |
| 53 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.26627182 |
| 54 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.26454145 |
| 55 | FUS_26573619_Chip-Seq_HEK293_Human | 1.26119589 |
| 56 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.24991684 |
| 57 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.24978284 |
| 58 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.24891530 |
| 59 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.24650560 |
| 60 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.21746250 |
| 61 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.21746250 |
| 62 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.20968267 |
| 63 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.19769320 |
| 64 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 1.19579288 |
| 65 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.19131922 |
| 66 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.18812738 |
| 67 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.18455532 |
| 68 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.18222943 |
| 69 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.17812699 |
| 70 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 1.16805200 |
| 71 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.16539592 |
| 72 | AR_19668381_ChIP-Seq_PC3_Human | 1.13067860 |
| 73 | STAT3_23295773_ChIP-Seq_U87_Human | 1.12587282 |
| 74 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.11785716 |
| 75 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.11689135 |
| 76 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 1.11226716 |
| 77 | KDM2B_26808549_Chip-Seq_K562_Human | 1.09875397 |
| 78 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.09583190 |
| 79 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 1.09221501 |
| 80 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.09156258 |
| 81 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.09096484 |
| 82 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.08987997 |
| 83 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.08718660 |
| 84 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.08414768 |
| 85 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.07223549 |
| 86 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.07123857 |
| 87 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.06743793 |
| 88 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.05735560 |
| 89 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.05637517 |
| 90 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.05619264 |
| 91 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.05313208 |
| 92 | AR_25329375_ChIP-Seq_VCAP_Human | 1.04088970 |
| 93 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.03475223 |
| 94 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.03114679 |
| 95 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.03105598 |
| 96 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.02621020 |
| 97 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.02347205 |
| 98 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.02308650 |
| 99 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.01061425 |
| 100 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.00796364 |
| 101 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 1.00705887 |
| 102 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.00378122 |
| 103 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 1.00307548 |
| 104 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.00133827 |
| 105 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 0.99639811 |
| 106 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.99540521 |
| 107 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.99463610 |
| 108 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.99444988 |
| 109 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 0.99400123 |
| 110 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.99019878 |
| 111 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.99017807 |
| 112 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.98479389 |
| 113 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.98295584 |
| 114 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.97766203 |
| 115 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 0.96648423 |
| 116 | P300_19829295_ChIP-Seq_ESCs_Human | 0.95433876 |
| 117 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 0.94766161 |
| 118 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 0.93471851 |
| 119 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.93219110 |
| 120 | TCF4_23295773_ChIP-Seq_U87_Human | 0.93057273 |
| 121 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.91892025 |
| 122 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.89950409 |
| 123 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 0.89701834 |
| 124 | TP53_16413492_ChIP-PET_HCT116_Human | 0.88445530 |
| 125 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.88371656 |
| 126 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.88338769 |
| 127 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.88198112 |
| 128 | CTCF_27219007_Chip-Seq_Bcells_Human | 0.87806387 |
| 129 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.87443715 |
| 130 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.87201024 |
| 131 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.86988368 |
| 132 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 0.85811740 |
| 133 | RXR_22108803_ChIP-Seq_LS180_Human | 0.84395745 |
| 134 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.84354887 |
| 135 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.84105552 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.14517059 |
| 2 | MP0002822_catalepsy | 3.58597855 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 3.28105605 |
| 4 | MP0004270_analgesia | 3.09319337 |
| 5 | MP0003880_abnormal_central_pattern | 3.05929514 |
| 6 | MP0009745_abnormal_behavioral_response | 2.78031670 |
| 7 | MP0002064_seizures | 2.67676616 |
| 8 | MP0002063_abnormal_learning/memory/cond | 2.58993146 |
| 9 | MP0009046_muscle_twitch | 2.57163160 |
| 10 | MP0003329_amyloid_beta_deposits | 2.43732025 |
| 11 | MP0001486_abnormal_startle_reflex | 2.41328762 |
| 12 | MP0002272_abnormal_nervous_system | 2.29775248 |
| 13 | MP0002572_abnormal_emotion/affect_behav | 2.16538985 |
| 14 | MP0008569_lethality_at_weaning | 2.02899995 |
| 15 | MP0002106_abnormal_muscle_physiology | 1.99190844 |
| 16 | MP0001968_abnormal_touch/_nociception | 1.95776846 |
| 17 | MP0002139_abnormal_hepatobiliary_system | 1.89322322 |
| 18 | MP0005423_abnormal_somatic_nervous | 1.88233684 |
| 19 | MP0000751_myopathy | 1.87250694 |
| 20 | MP0003183_abnormal_peptide_metabolism | 1.86293935 |
| 21 | MP0001984_abnormal_olfaction | 1.86054119 |
| 22 | MP0004885_abnormal_endolymph | 1.85974621 |
| 23 | MP0003690_abnormal_glial_cell | 1.84157243 |
| 24 | MP0002734_abnormal_mechanical_nocicepti | 1.75229487 |
| 25 | MP0000920_abnormal_myelination | 1.73566005 |
| 26 | MP0001440_abnormal_grooming_behavior | 1.71980205 |
| 27 | MP0002067_abnormal_sensory_capabilities | 1.71692176 |
| 28 | MP0001501_abnormal_sleep_pattern | 1.71311625 |
| 29 | MP0000759_abnormal_skeletal_muscle | 1.70360990 |
| 30 | MP0005369_muscle_phenotype | 1.68437621 |
| 31 | MP0002332_abnormal_exercise_endurance | 1.66711738 |
| 32 | MP0002837_dystrophic_cardiac_calcinosis | 1.63483640 |
| 33 | MP0004036_abnormal_muscle_relaxation | 1.63279440 |
| 34 | MP0005386_behavior/neurological_phenoty | 1.62224568 |
| 35 | MP0004924_abnormal_behavior | 1.62224568 |
| 36 | MP0003633_abnormal_nervous_system | 1.59117567 |
| 37 | MP0005187_abnormal_penis_morphology | 1.58228791 |
| 38 | MP0009780_abnormal_chondrocyte_physiolo | 1.55377363 |
| 39 | MP0005085_abnormal_gallbladder_physiolo | 1.49838450 |
| 40 | MP0000604_amyloidosis | 1.48137085 |
| 41 | MP0001529_abnormal_vocalization | 1.46457971 |
| 42 | MP0004215_abnormal_myocardial_fiber | 1.46379661 |
| 43 | MP0005360_urolithiasis | 1.45814303 |
| 44 | MP0002736_abnormal_nociception_after | 1.45705559 |
| 45 | MP0008875_abnormal_xenobiotic_pharmacok | 1.45632955 |
| 46 | MP0002909_abnormal_adrenal_gland | 1.40168398 |
| 47 | MP0005365_abnormal_bile_salt | 1.38405672 |
| 48 | MP0003631_nervous_system_phenotype | 1.36870456 |
| 49 | MP0004130_abnormal_muscle_cell | 1.36757146 |
| 50 | MP0002733_abnormal_thermal_nociception | 1.35511558 |
| 51 | MP0003646_muscle_fatigue | 1.35434929 |
| 52 | MP0005551_abnormal_eye_electrophysiolog | 1.35040823 |
| 53 | MP0000778_abnormal_nervous_system | 1.34011120 |
| 54 | MP0002735_abnormal_chemical_nociception | 1.32116805 |
| 55 | MP0001970_abnormal_pain_threshold | 1.31386857 |
| 56 | MP0005670_abnormal_white_adipose | 1.31038595 |
| 57 | MP0002557_abnormal_social/conspecific_i | 1.30215148 |
| 58 | MP0004811_abnormal_neuron_physiology | 1.30181882 |
| 59 | MP0002229_neurodegeneration | 1.29802314 |
| 60 | MP0005646_abnormal_pituitary_gland | 1.29174623 |
| 61 | MP0002066_abnormal_motor_capabilities/c | 1.28518752 |
| 62 | MP0001502_abnormal_circadian_rhythm | 1.27611924 |
| 63 | MP0000955_abnormal_spinal_cord | 1.26460401 |
| 64 | MP0004043_abnormal_pH_regulation | 1.25420857 |
| 65 | MP0004084_abnormal_cardiac_muscle | 1.24287730 |
| 66 | MP0000750_abnormal_muscle_regeneration | 1.23882547 |
| 67 | MP0001485_abnormal_pinna_reflex | 1.22751901 |
| 68 | MP0000749_muscle_degeneration | 1.22566104 |
| 69 | MP0003137_abnormal_impulse_conducting | 1.22355813 |
| 70 | MP0002882_abnormal_neuron_morphology | 1.21542019 |
| 71 | MP0003172_abnormal_lysosome_physiology | 1.21186162 |
| 72 | MP0003634_abnormal_glial_cell | 1.20451740 |
| 73 | MP0004142_abnormal_muscle_tone | 1.19090410 |
| 74 | MP0002184_abnormal_innervation | 1.16565370 |
| 75 | MP0004145_abnormal_muscle_electrophysio | 1.16489222 |
| 76 | MP0003632_abnormal_nervous_system | 1.15969449 |
| 77 | MP0000747_muscle_weakness | 1.15745091 |
| 78 | MP0002090_abnormal_vision | 1.14431805 |
| 79 | MP0004085_abnormal_heartbeat | 1.13319781 |
| 80 | MP0002638_abnormal_pupillary_reflex | 1.11255712 |
| 81 | MP0002127_abnormal_cardiovascular_syste | 1.09527217 |
| 82 | MP0003136_yellow_coat_color | 1.06812796 |
| 83 | MP0006036_abnormal_mitochondrial_physio | 1.06698260 |
| 84 | MP0005535_abnormal_body_temperature | 1.05677325 |
| 85 | MP0003879_abnormal_hair_cell | 1.05395728 |
| 86 | MP0008874_decreased_physiological_sensi | 1.04985595 |
| 87 | MP0010329_abnormal_lipoprotein_level | 1.03005563 |
| 88 | MP0001346_abnormal_lacrimal_gland | 1.01161102 |
| 89 | MP0005167_abnormal_blood-brain_barrier | 1.01011125 |
| 90 | MP0005620_abnormal_muscle_contractility | 0.97120206 |
| 91 | MP0004858_abnormal_nervous_system | 0.94724528 |
| 92 | MP0005083_abnormal_biliary_tract | 0.92950237 |
| 93 | MP0004087_abnormal_muscle_fiber | 0.92583668 |
| 94 | MP0004510_myositis | 0.91792026 |
| 95 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.90917464 |
| 96 | MP0005253_abnormal_eye_physiology | 0.90848746 |
| 97 | MP0005330_cardiomyopathy | 0.90767314 |
| 98 | MP0001905_abnormal_dopamine_level | 0.90516938 |
| 99 | MP0004233_abnormal_muscle_weight | 0.89669864 |
| 100 | MP0002108_abnormal_muscle_morphology | 0.89118756 |
| 101 | MP0003075_altered_response_to | 0.88481804 |
| 102 | MP0004147_increased_porphyrin_level | 0.87809042 |
| 103 | MP0001986_abnormal_taste_sensitivity | 0.87626553 |
| 104 | MP0002118_abnormal_lipid_homeostasis | 0.86359729 |
| 105 | MP0008961_abnormal_basal_metabolism | 0.85213755 |
| 106 | MP0002152_abnormal_brain_morphology | 0.85056007 |
| 107 | MP0002653_abnormal_ependyma_morphology | 0.84237050 |
| 108 | MP0004484_altered_response_of | 0.84061153 |
| 109 | MP0008872_abnormal_physiological_respon | 0.83377037 |
| 110 | MP0006276_abnormal_autonomic_nervous | 0.83193393 |
| 111 | MP0001544_abnormal_cardiovascular_syste | 0.82807433 |
| 112 | MP0005385_cardiovascular_system_phenoty | 0.82807433 |
| 113 | MP0002269_muscular_atrophy | 0.82123250 |
| 114 | MP0002972_abnormal_cardiac_muscle | 0.81464567 |
| 115 | MP0000013_abnormal_adipose_tissue | 0.81354098 |
| 116 | MP0008877_abnormal_DNA_methylation | 0.80689766 |
| 117 | MP0002069_abnormal_eating/drinking_beha | 0.80575199 |
| 118 | MP0004742_abnormal_vestibular_system | 0.80280682 |
| 119 | MP0005645_abnormal_hypothalamus_physiol | 0.80106821 |
| 120 | MP0009840_abnormal_foam_cell | 0.78865303 |
| 121 | MP0000383_abnormal_hair_follicle | 0.77475295 |
| 122 | MP0010630_abnormal_cardiac_muscle | 0.77262440 |
| 123 | MP0003787_abnormal_imprinting | 0.76214470 |
| 124 | MP0006138_congestive_heart_failure | 0.73945100 |
| 125 | MP0001177_atelectasis | 0.72539903 |
| 126 | MP0002876_abnormal_thyroid_physiology | 0.71504639 |
| 127 | MP0001299_abnormal_eye_distance/ | 0.69195238 |
| 128 | MP0001963_abnormal_hearing_physiology | 0.68242523 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Muscle fiber inclusion bodies (HP:0100299) | 7.29410028 |
| 2 | Nemaline bodies (HP:0003798) | 7.09207340 |
| 3 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 6.94904370 |
| 4 | Myokymia (HP:0002411) | 5.21892619 |
| 5 | Type 1 muscle fiber predominance (HP:0003803) | 4.97138927 |
| 6 | Focal motor seizures (HP:0011153) | 4.55908938 |
| 7 | Abnormality of the left ventricular outflow tract (HP:0011103) | 3.93124876 |
| 8 | Subaortic stenosis (HP:0001682) | 3.93124876 |
| 9 | Neurofibrillary tangles (HP:0002185) | 3.73542211 |
| 10 | Focal seizures (HP:0007359) | 3.71630936 |
| 11 | Muscle fiber splitting (HP:0003555) | 3.59743269 |
| 12 | Myopathic facies (HP:0002058) | 3.54660900 |
| 13 | Rimmed vacuoles (HP:0003805) | 3.53647728 |
| 14 | Supranuclear gaze palsy (HP:0000605) | 3.53549573 |
| 15 | Distal arthrogryposis (HP:0005684) | 3.52813922 |
| 16 | Frequent falls (HP:0002359) | 3.48899812 |
| 17 | Action tremor (HP:0002345) | 3.33322748 |
| 18 | Exercise-induced myalgia (HP:0003738) | 3.33269302 |
| 19 | Progressive cerebellar ataxia (HP:0002073) | 3.30392065 |
| 20 | Cerebral inclusion bodies (HP:0100314) | 3.22022719 |
| 21 | Dysdiadochokinesis (HP:0002075) | 3.20719258 |
| 22 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 3.14059890 |
| 23 | Insidious onset (HP:0003587) | 3.11192028 |
| 24 | Termporal pattern (HP:0011008) | 3.11192028 |
| 25 | Abnormal respiratory motile cilium morphology (HP:0005938) | 3.06766061 |
| 26 | Abnormal respiratory epithelium morphology (HP:0012253) | 3.06766061 |
| 27 | Neck muscle weakness (HP:0000467) | 3.05744267 |
| 28 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 3.02388243 |
| 29 | Absent/shortened dynein arms (HP:0200106) | 3.02388243 |
| 30 | Intention tremor (HP:0002080) | 3.02269795 |
| 31 | Dysmetria (HP:0001310) | 3.01459465 |
| 32 | Epileptic encephalopathy (HP:0200134) | 3.00664480 |
| 33 | Visual hallucinations (HP:0002367) | 3.00025208 |
| 34 | Broad-based gait (HP:0002136) | 2.99304449 |
| 35 | Fetal akinesia sequence (HP:0001989) | 2.97911462 |
| 36 | Postural instability (HP:0002172) | 2.91624280 |
| 37 | Rhabdomyolysis (HP:0003201) | 2.84640140 |
| 38 | Hyperkalemia (HP:0002153) | 2.84074554 |
| 39 | Abnormal social behavior (HP:0012433) | 2.83920047 |
| 40 | Impaired social interactions (HP:0000735) | 2.83920047 |
| 41 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 2.83018643 |
| 42 | Abnormal ciliary motility (HP:0012262) | 2.82499772 |
| 43 | Atonic seizures (HP:0010819) | 2.79789011 |
| 44 | Abnormality of the corticospinal tract (HP:0002492) | 2.79589185 |
| 45 | Poor eye contact (HP:0000817) | 2.79575749 |
| 46 | Abnormal respiratory motile cilium physiology (HP:0012261) | 2.79480879 |
| 47 | Ankle clonus (HP:0011448) | 2.78758861 |
| 48 | Generalized tonic-clonic seizures (HP:0002069) | 2.75038806 |
| 49 | Hyperventilation (HP:0002883) | 2.74702008 |
| 50 | Depression (HP:0000716) | 2.73816963 |
| 51 | Scanning speech (HP:0002168) | 2.69116141 |
| 52 | Spastic gait (HP:0002064) | 2.65634289 |
| 53 | Myotonia (HP:0002486) | 2.64405442 |
| 54 | Absence seizures (HP:0002121) | 2.64223840 |
| 55 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.61898499 |
| 56 | EMG: neuropathic changes (HP:0003445) | 2.60108014 |
| 57 | Rhinitis (HP:0012384) | 2.57810624 |
| 58 | Abnormality of the lower motor neuron (HP:0002366) | 2.55833108 |
| 59 | Status epilepticus (HP:0002133) | 2.53283930 |
| 60 | Dysmetric saccades (HP:0000641) | 2.53073509 |
| 61 | Truncal ataxia (HP:0002078) | 2.52906945 |
| 62 | Central scotoma (HP:0000603) | 2.51487544 |
| 63 | Urinary urgency (HP:0000012) | 2.49713419 |
| 64 | Sudden death (HP:0001699) | 2.49064302 |
| 65 | Torticollis (HP:0000473) | 2.48480146 |
| 66 | Febrile seizures (HP:0002373) | 2.48436173 |
| 67 | Hyporeflexia of lower limbs (HP:0002600) | 2.47895809 |
| 68 | Dialeptic seizures (HP:0011146) | 2.47291363 |
| 69 | Prolonged QT interval (HP:0001657) | 2.46691306 |
| 70 | Drooling (HP:0002307) | 2.46444925 |
| 71 | Excessive salivation (HP:0003781) | 2.46444925 |
| 72 | Gaze-evoked nystagmus (HP:0000640) | 2.41332952 |
| 73 | Anxiety (HP:0000739) | 2.40880625 |
| 74 | Round ear (HP:0100830) | 2.39309658 |
| 75 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.39058638 |
| 76 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.38479435 |
| 77 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.38479435 |
| 78 | Abnormal atrioventricular conduction (HP:0005150) | 2.31060203 |
| 79 | Bundle branch block (HP:0011710) | 2.30731264 |
| 80 | Syncope (HP:0001279) | 2.29707470 |
| 81 | Abnormal eating behavior (HP:0100738) | 2.29107958 |
| 82 | Megalencephaly (HP:0001355) | 2.29057829 |
| 83 | Chronic bronchitis (HP:0004469) | 2.24691983 |
| 84 | Blue irides (HP:0000635) | 2.21388411 |
| 85 | Focal dystonia (HP:0004373) | 2.19997065 |
| 86 | Calf muscle hypertrophy (HP:0008981) | 2.19221026 |
| 87 | Muscle hypertrophy of the lower extremities (HP:0008968) | 2.17106474 |
| 88 | Areflexia of lower limbs (HP:0002522) | 2.16900630 |
| 89 | Clumsiness (HP:0002312) | 2.16285164 |
| 90 | Progressive inability to walk (HP:0002505) | 2.14903294 |
| 91 | Exercise-induced muscle cramps (HP:0003710) | 2.14721939 |
| 92 | Neuronal loss in central nervous system (HP:0002529) | 2.11646962 |
| 93 | Craniofacial dystonia (HP:0012179) | 2.11257095 |
| 94 | Onion bulb formation (HP:0003383) | 2.11056200 |
| 95 | Decreased circulating renin level (HP:0003351) | 2.10913006 |
| 96 | Absent phalangeal crease (HP:0006109) | 2.10428314 |
| 97 | Difficulty running (HP:0009046) | 2.09727721 |
| 98 | Impaired vibratory sensation (HP:0002495) | 2.09190156 |
| 99 | Ventricular fibrillation (HP:0001663) | 2.08648361 |
| 100 | Spastic tetraparesis (HP:0001285) | 2.08623046 |
| 101 | Lower limb muscle weakness (HP:0007340) | 2.07754439 |
| 102 | Abnormality of the calf musculature (HP:0001430) | 2.06502915 |
| 103 | Left ventricular hypertrophy (HP:0001712) | 2.03638258 |
| 104 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 2.03107313 |
| 105 | Hyperlipoproteinemia (HP:0010980) | 2.01042689 |
| 106 | Absent speech (HP:0001344) | 2.00867844 |
| 107 | Rigidity (HP:0002063) | 2.00629326 |
| 108 | Atrioventricular block (HP:0001678) | 2.00470348 |
| 109 | Abnormality of saccadic eye movements (HP:0000570) | 2.00189357 |
| 110 | Hemiplegia (HP:0002301) | 1.99930182 |
| 111 | Genetic anticipation (HP:0003743) | 1.98077567 |
| 112 | Muscle stiffness (HP:0003552) | 1.97209691 |
| 113 | Pheochromocytoma (HP:0002666) | 1.95781272 |
| 114 | Bradykinesia (HP:0002067) | 1.95070984 |
| 115 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.92408799 |
| 116 | Stereotypic behavior (HP:0000733) | 1.91418610 |
| 117 | Abnormal EKG (HP:0003115) | 1.90300285 |
| 118 | Abnormality of skeletal muscle fiber size (HP:0012084) | 1.89981275 |
| 119 | Abnormal finger flexion creases (HP:0006143) | 1.89758657 |
| 120 | Ulnar deviation of the wrist (HP:0003049) | 1.88656817 |
| 121 | Asymmetric septal hypertrophy (HP:0001670) | 1.88654024 |
| 122 | Mutism (HP:0002300) | 1.87950467 |
| 123 | Rapidly progressive (HP:0003678) | 1.87000313 |
| 124 | Sleep apnea (HP:0010535) | 1.86948806 |
| 125 | Abnormality of vision evoked potentials (HP:0000649) | 1.86921927 |
| 126 | Clonus (HP:0002169) | 1.86836799 |
| 127 | Ventricular tachycardia (HP:0004756) | 1.86451577 |
| 128 | Myoglobinuria (HP:0002913) | 1.86085684 |
| 129 | Hemiparesis (HP:0001269) | 1.85225408 |
| 130 | Proximal amyotrophy (HP:0007126) | 1.84368862 |
| 131 | Gait ataxia (HP:0002066) | 1.83695271 |
| 132 | True hermaphroditism (HP:0010459) | 1.83643931 |
| 133 | Intrahepatic cholestasis (HP:0001406) | 1.82768799 |
| 134 | Atrial fibrillation (HP:0005110) | 1.82745567 |
| 135 | Heart block (HP:0012722) | 1.82620386 |
| 136 | Distal lower limb muscle weakness (HP:0009053) | 1.81715521 |
| 137 | Ventricular arrhythmia (HP:0004308) | 1.80499623 |
| 138 | Diplopia (HP:0000651) | 1.79161077 |
| 139 | Abnormality of binocular vision (HP:0011514) | 1.79161077 |
| 140 | EMG: myopathic abnormalities (HP:0003458) | 1.76702059 |
| 141 | Dilated cardiomyopathy (HP:0001644) | 1.76491577 |
| 142 | Hyperglycinuria (HP:0003108) | 1.76331181 |
| 143 | Primary atrial arrhythmia (HP:0001692) | 1.74763611 |
| 144 | Postural tremor (HP:0002174) | 1.74635694 |
| 145 | Xanthomatosis (HP:0000991) | 1.73906132 |
| 146 | Morphological abnormality of the pyramidal tract (HP:0002062) | 1.72528374 |
| 147 | Scapular winging (HP:0003691) | 1.71159263 |
| 148 | Calcaneovalgus deformity (HP:0001848) | 1.71060050 |
| 149 | Abnormality of potassium homeostasis (HP:0011042) | 1.70663436 |
| 150 | Increased connective tissue (HP:0009025) | 1.70269950 |
| 151 | Steppage gait (HP:0003376) | 1.68955912 |
| 152 | Limb-girdle muscle atrophy (HP:0003797) | 1.68204518 |
| 153 | Oligomenorrhea (HP:0000876) | 1.66749674 |
| 154 | Abnormality of the foot musculature (HP:0001436) | 1.66501704 |
| 155 | Hypokalemia (HP:0002900) | 1.64596921 |
| 156 | Gait imbalance (HP:0002141) | 1.64367860 |
| 157 | Hyperactive renin-angiotensin system (HP:0000841) | 1.61684433 |
| 158 | Hyperaldosteronism (HP:0000859) | 1.59658206 |
| 159 | Gowers sign (HP:0003391) | 1.59503347 |
| 160 | Gout (HP:0001997) | 1.59179378 |
| 161 | Supraventricular tachycardia (HP:0004755) | 1.58548056 |
| 162 | Unsteady gait (HP:0002317) | 1.58314135 |
| 163 | Increased variability in muscle fiber diameter (HP:0003557) | 1.57837383 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FRK | 3.69666715 |
| 2 | EPHA4 | 3.61241154 |
| 3 | NTRK3 | 2.80863325 |
| 4 | WNK3 | 2.73584736 |
| 5 | MAP3K9 | 2.62192244 |
| 6 | DAPK2 | 2.30243207 |
| 7 | PHKG2 | 2.22033369 |
| 8 | PHKG1 | 2.22033369 |
| 9 | PAK6 | 2.15805364 |
| 10 | MAP3K4 | 2.12099158 |
| 11 | MARK1 | 2.08864437 |
| 12 | MAP2K4 | 1.80745265 |
| 13 | MINK1 | 1.70609785 |
| 14 | KSR2 | 1.66894330 |
| 15 | PRKD3 | 1.65128640 |
| 16 | NTRK2 | 1.61429830 |
| 17 | CAMKK1 | 1.55249382 |
| 18 | OXSR1 | 1.54507185 |
| 19 | PRPF4B | 1.53587918 |
| 20 | EEF2K | 1.52966844 |
| 21 | MAP3K13 | 1.52793174 |
| 22 | MAPKAPK3 | 1.52242403 |
| 23 | SGK494 | 1.52011129 |
| 24 | SGK223 | 1.52011129 |
| 25 | LMTK2 | 1.49759749 |
| 26 | CDK19 | 1.47140954 |
| 27 | MAP2K7 | 1.44991536 |
| 28 | CASK | 1.42831046 |
| 29 | STK38 | 1.40199895 |
| 30 | FGFR2 | 1.36205186 |
| 31 | CDK5 | 1.35311008 |
| 32 | CAMKK2 | 1.29591874 |
| 33 | TYRO3 | 1.29490422 |
| 34 | MAP3K7 | 1.29310058 |
| 35 | STK39 | 1.24444215 |
| 36 | NTRK1 | 1.21678545 |
| 37 | CAMK1G | 1.15943984 |
| 38 | SGK3 | 1.15112701 |
| 39 | PRKCH | 1.12583817 |
| 40 | UHMK1 | 1.10782815 |
| 41 | MAPK15 | 1.10627590 |
| 42 | ERBB3 | 1.09788472 |
| 43 | CAMK2B | 1.09457368 |
| 44 | ICK | 1.08937069 |
| 45 | PINK1 | 1.07879545 |
| 46 | TRPM7 | 1.06383809 |
| 47 | RIPK1 | 1.03380292 |
| 48 | SGK2 | 1.01466652 |
| 49 | PDPK1 | 0.99806101 |
| 50 | CAMK2A | 0.98292012 |
| 51 | CAMK2D | 0.97147962 |
| 52 | PAK3 | 0.97114716 |
| 53 | SIK2 | 0.95767692 |
| 54 | STK11 | 0.95598776 |
| 55 | MAP3K2 | 0.95179120 |
| 56 | PDK1 | 0.94285194 |
| 57 | TSSK6 | 0.93324734 |
| 58 | PKN1 | 0.92359494 |
| 59 | TNIK | 0.89879040 |
| 60 | CAMK2G | 0.88935722 |
| 61 | MARK2 | 0.88599752 |
| 62 | WNK1 | 0.88383596 |
| 63 | FER | 0.87311096 |
| 64 | CAMK1 | 0.87137752 |
| 65 | TAOK1 | 0.86597076 |
| 66 | KSR1 | 0.86385426 |
| 67 | PLK2 | 0.85878542 |
| 68 | INSRR | 0.84238841 |
| 69 | OBSCN | 0.82510793 |
| 70 | MUSK | 0.82158411 |
| 71 | TTN | 0.81725659 |
| 72 | FES | 0.81040188 |
| 73 | LIMK1 | 0.80503496 |
| 74 | NEK1 | 0.80296320 |
| 75 | STK38L | 0.79642706 |
| 76 | SGK1 | 0.78906151 |
| 77 | MAPK12 | 0.78191221 |
| 78 | CSNK1G2 | 0.77386188 |
| 79 | CAMK4 | 0.77105341 |
| 80 | RIPK4 | 0.75725760 |
| 81 | RET | 0.74230981 |
| 82 | LATS2 | 0.72887143 |
| 83 | DMPK | 0.71408059 |
| 84 | PRKCG | 0.70522299 |
| 85 | CDC42BPA | 0.69756190 |
| 86 | DDR2 | 0.69680017 |
| 87 | CAMK1D | 0.69012124 |
| 88 | EPHB1 | 0.67990095 |
| 89 | CCNB1 | 0.67891889 |
| 90 | PRKAA1 | 0.67247288 |
| 91 | MAP3K1 | 0.66353354 |
| 92 | MAPK13 | 0.65340897 |
| 93 | CDK18 | 0.64579364 |
| 94 | PDK4 | 0.64505963 |
| 95 | PDK3 | 0.64505963 |
| 96 | CDK15 | 0.64123252 |
| 97 | PRKCZ | 0.63155919 |
| 98 | PIK3CG | 0.62829188 |
| 99 | CDK14 | 0.62592280 |
| 100 | PRKAA2 | 0.62494160 |
| 101 | ROCK2 | 0.62277026 |
| 102 | TRIB3 | 0.62201590 |
| 103 | MAPK10 | 0.61664492 |
| 104 | MAPKAPK5 | 0.60506487 |
| 105 | RPS6KA3 | 0.59285358 |
| 106 | DAPK1 | 0.59191673 |
| 107 | PTK2B | 0.58458868 |
| 108 | MAP3K12 | 0.57022749 |
| 109 | PRKD1 | 0.56733276 |
| 110 | GRK5 | 0.56043885 |
| 111 | NEK6 | 0.54728174 |
| 112 | FYN | 0.54614704 |
| 113 | PRKCE | 0.54418364 |
| 114 | BMPR1B | 0.54301585 |
| 115 | YES1 | 0.53946548 |
| 116 | DAPK3 | 0.53336738 |
| 117 | DYRK1A | 0.51882842 |
| 118 | PRKACA | 0.51475966 |
| 119 | CDK11A | 0.51063471 |
| 120 | PIK3CA | 0.50841643 |
| 121 | BCR | 0.50475480 |
| 122 | WNK4 | 0.50406207 |
| 123 | PRKG1 | 0.50004702 |
| 124 | EPHA3 | 0.48334243 |
| 125 | MAP2K1 | 0.44386027 |
| 126 | AKT2 | 0.42744176 |
| 127 | ROCK1 | 0.39035004 |
| 128 | EIF2AK3 | 0.38748680 |
| 129 | RPS6KB1 | 0.38349315 |
| 130 | PRKACB | 0.37574032 |
| 131 | LATS1 | 0.36052193 |
| 132 | NME1 | 0.33208476 |
| 133 | PRKDC | 0.31505630 |
| 134 | GRK1 | 0.31073013 |
| 135 | PRKCA | 0.30493457 |
| 136 | GSK3B | 0.27454461 |
| 137 | TRIM28 | 0.25975485 |
| 138 | CSNK1E | 0.25923999 |
| 139 | MAPK7 | 0.24415516 |
| 140 | ZAK | 0.23735237 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nitrogen metabolism_Homo sapiens_hsa00910 | 3.58878877 |
| 2 | Olfactory transduction_Homo sapiens_hsa04740 | 2.19364979 |
| 3 | Nicotine addiction_Homo sapiens_hsa05033 | 2.17604846 |
| 4 | GABAergic synapse_Homo sapiens_hsa04727 | 2.02454384 |
| 5 | Circadian entrainment_Homo sapiens_hsa04713 | 2.02213578 |
| 6 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.00650543 |
| 7 | Histidine metabolism_Homo sapiens_hsa00340 | 1.98538008 |
| 8 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.86187821 |
| 9 | Morphine addiction_Homo sapiens_hsa05032 | 1.77741318 |
| 10 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.75632920 |
| 11 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.72257226 |
| 12 | Long-term potentiation_Homo sapiens_hsa04720 | 1.69191156 |
| 13 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.67035524 |
| 14 | Salivary secretion_Homo sapiens_hsa04970 | 1.62519752 |
| 15 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.60569371 |
| 16 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.60117419 |
| 17 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.59200308 |
| 18 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.50159661 |
| 19 | Insulin secretion_Homo sapiens_hsa04911 | 1.48475677 |
| 20 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.47889378 |
| 21 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.46875607 |
| 22 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.46130642 |
| 23 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.44482809 |
| 24 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.42601243 |
| 25 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.38162541 |
| 26 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.35039706 |
| 27 | Cocaine addiction_Homo sapiens_hsa05030 | 1.32494864 |
| 28 | Bile secretion_Homo sapiens_hsa04976 | 1.31444806 |
| 29 | Renin secretion_Homo sapiens_hsa04924 | 1.30811688 |
| 30 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.30785264 |
| 31 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.29733139 |
| 32 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.22514119 |
| 33 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.16256534 |
| 34 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.15401818 |
| 35 | Long-term depression_Homo sapiens_hsa04730 | 1.11405248 |
| 36 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.10916734 |
| 37 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.09816333 |
| 38 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.09624833 |
| 39 | Fatty acid degradation_Homo sapiens_hsa00071 | 1.06478647 |
| 40 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.03040419 |
| 41 | Phototransduction_Homo sapiens_hsa04744 | 1.02338974 |
| 42 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.01792528 |
| 43 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.00539093 |
| 44 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.00412367 |
| 45 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.98826774 |
| 46 | Taste transduction_Homo sapiens_hsa04742 | 0.97668496 |
| 47 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.96554588 |
| 48 | Gap junction_Homo sapiens_hsa04540 | 0.95822190 |
| 49 | Tight junction_Homo sapiens_hsa04530 | 0.94325789 |
| 50 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.93559119 |
| 51 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.93535273 |
| 52 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.89873692 |
| 53 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.89192506 |
| 54 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.88744322 |
| 55 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.88518282 |
| 56 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.86641264 |
| 57 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.85940734 |
| 58 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.83486844 |
| 59 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.81885171 |
| 60 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.81732171 |
| 61 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.81726058 |
| 62 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.80780929 |
| 63 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.80400292 |
| 64 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.80354595 |
| 65 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.80056531 |
| 66 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.80013318 |
| 67 | Lysine degradation_Homo sapiens_hsa00310 | 0.78511776 |
| 68 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.76715896 |
| 69 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.76544717 |
| 70 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.76361096 |
| 71 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.76273283 |
| 72 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.75011935 |
| 73 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.74170680 |
| 74 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.74102578 |
| 75 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.72937555 |
| 76 | Axon guidance_Homo sapiens_hsa04360 | 0.72829142 |
| 77 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.69090193 |
| 78 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.68923446 |
| 79 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.68817227 |
| 80 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.68428087 |
| 81 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.67182246 |
| 82 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.66925693 |
| 83 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.65051162 |
| 84 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.64116026 |
| 85 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.63105500 |
| 86 | Alzheimers disease_Homo sapiens_hsa05010 | 0.62948173 |
| 87 | Melanogenesis_Homo sapiens_hsa04916 | 0.62587391 |
| 88 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.62568907 |
| 89 | ABC transporters_Homo sapiens_hsa02010 | 0.60637488 |
| 90 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.60102778 |
| 91 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.59850333 |
| 92 | Glioma_Homo sapiens_hsa05214 | 0.57179612 |
| 93 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.56134542 |
| 94 | Huntingtons disease_Homo sapiens_hsa05016 | 0.54346787 |
| 95 | Peroxisome_Homo sapiens_hsa04146 | 0.53955087 |
| 96 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.52505072 |
| 97 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.52355010 |
| 98 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.51480136 |
| 99 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.51249601 |
| 100 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.50927562 |
| 101 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.49645071 |
| 102 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.47665993 |
| 103 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.47453936 |
| 104 | Carbon metabolism_Homo sapiens_hsa01200 | 0.47325420 |
| 105 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.47144210 |
| 106 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.45581177 |
| 107 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.44504758 |
| 108 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.42781117 |
| 109 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.41942433 |
| 110 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.41859203 |
| 111 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.41625530 |
| 112 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.40151339 |
| 113 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.40056551 |
| 114 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.39638002 |
| 115 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.39512844 |
| 116 | Parkinsons disease_Homo sapiens_hsa05012 | 0.38823821 |
| 117 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.38675440 |
| 118 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.37429538 |
| 119 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.37305779 |
| 120 | Insulin resistance_Homo sapiens_hsa04931 | 0.35919938 |
| 121 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.35844391 |
| 122 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.34882080 |
| 123 | Circadian rhythm_Homo sapiens_hsa04710 | 0.34617349 |

